Phenylimidazolidines having antiandrogenic activity
A compound of the formula ##STR1## wherein R.sub.1 is --CN, --NO.sub.2 or halogen, R.sub.2 is --CF.sub.3 or halogen, --A--B-- is of ##STR2## X is --O-- or --S--, R.sub.3 is hydrogen, alkyl, alkenyl or alkynyl of up to 12 carbon atoms, aryl and aralkyl of up to 12 carbon atoms, all optionally substituted by --OH, halogen, --SH, --CN, acyl and acyloxy of up to 7 carbon atoms, --aryl, --O--aryl, --O--aralkyl --S-- aryl of up to 12 carbon atoms the aryl and aralkyl being optionally substituted by halogen, --CF.sub.3, alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl or alkynyloxy with the sulfur being optionally oxidized to sulfone or sulfoxide, free, esterified, amidified or salified carboxy, --NH.sub.2, mono and dialkylamino and heterocyclic of 3 to 6 ring members and containing at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen, the alkyl, alkenyl and alkynyl being optionally interrupted by at least one oxygen, nitrogen or sulfur optionally oxidized to sulfoxide or sulfone, trialkylsilyl with the alkyl having 1 to 6 carbon atoms and acyl and acyloxy of an organic carboxylic acid of 1 to 7 carbon atoms and Y is --O--, --S-- or --NH--, except the compounds wherein --A-B-- is ##STR3## X is oxygen, R.sub.3 is hydrogen and Y is oxygen or --NH--, R.sub.2 is --CF.sub.3 or halogen and R.sub.1 is --NO.sub.2 or halogen and their non-toxic, pharmaceutically acceptable acid addition salts.
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Claims
2. A compound of claim 1 wherein Y is oxygen.
3. A compound of claim 1 wherein --A-B-- is ##STR35## and X is sulfur.
4. A compound of claim 3 wherein R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms optionally substituted with a --OH or methoxy.
5. A compound of claim 1 wherein R.sub.1 is --CN or halogen.
6. A compound of claim 1 wherein R.sub.1 is chlorine.
8. A compound of claim 7 wherein R.sub.3 is alkyl of 1 to 6 carbon atoms unsubstituted or substituted by at least one member of the group consisting of halogen, --OH, --O acyl, carboxy, carboxy esterified with alkyl, a heterocycle, O-alkyl and unoxidized or oxidized S-aryl with the aryl unsubstituted or substituted with at least one member of the group consisting of halogen and alkoxy.
11. A compound of claim 1 selected from the group consisting of 4-(5-oxo-2-thioxo-3,4,4-trimethyl-1-imidazolidinyl)-2-(trifluoromethyl) benzonitrile, 4-(4,4-dimethyl-5-oxo-2-thioxo 1-imidazolidinyl)-2-(trifluoromethyl)-benzonitrile, 4-4,4-dimethyl-3-(2-hydroxyethyl)-5-oxo-2-thioxo-1-imidazolidinyl 2-(trifluoromethyl)-benzonitrile, 3-(3,4-dichlorophenyl)-2-thioxo-1,5,5-trimethyl-4-imidazolidinone, 1-(4-nitro-3-(trifluoromethyl) phenyl-3,4,4-trimethyl-2,5-imidazolidinedione, 4-4,5-dihydro4,4-dimethyl-5-oxo-2-(phenylmethyl) thio-1H-imidazol-1-yl-2-(trifluoromethyl) benzonitrile, 4 4,4-dimethyl 3-(2-hydroxyethyl) 5-oxo 2-thioxo 1-imidazolidinyl 2-(trifluoromethyl) benzonitrile, 4-(4,4-dimethyl 3-(4-hydroxybutyl) 5-oxo 2-thioxo 1-imidazolidinyl) 2-(trifluoromethyl) benzonitrile, 3-(4-cyano 3-trifluoromethyl) phenyl) 5,5-dimethyl 2,4-dioxo 1-imidazolidinebutanoic acid and 4-(4,4-dimethyl 2,5-dioxo 3-(4-hydroxybutyl) 1-imidazolidinyl) 2-(trifluoromethyl benzonitrile.
12. A compound of claim 1 wherein Y is --O-- except the compounds wherein the --A-B-- group is ##STR37## in which X is oxygen and R.sub.3 is hydrogen, R.sub.2 is halogen or trifluoromethyl and R.sub.1 is nitro or halogen.
13. A compound of the formula ##STR38## wherein R.sub.1, R.sub.2 and Y have the definitions of claim 1, --A--.sub.i --B.sub.1 is ##STR39## Y is oxygen or sulfur and R'.sub.3 is R.sub.3 with any reactive functions protected.
14. An anti-androgenic composition comprising an anti-androgenically effective amount of at least one compound of claim 1 and an inert pharmaceutical carrier.
15. A composition of claim 14 wherein the active compound is selected from the group consisting of 4-(5-oxo-2-thioxo-3,4,4-trimethyl-1-imidazolidinyl) 2-(trifluoromethyl)-be nzonitrile, 4-(4,4-dimethyl-5-oxo-2-thioxo 1-imidazolidinyl) 2-(trifluoromethyl)-benzoitrile, 4-4.4-dimethyl-3-(2-hydroxyethyl)-5-oxo-2-thioxo 1-imidazolidinyl-2-(trifluoromethyl)-benzonitrile, 3-(3,4-dichlorophenyl) 2-thioxo-1,5,5,-trimethyl-4-imidazolidinone, 1-(4-nitro-3-(trifluoromethyl)-phenyl-3,4,4-trimethyl-2.5-imidazolidinedio ne, 4-4,5-dihydro4,4-dimethyl-5-oxo-2-(phenylmethyl)thio-1H-imidazol 1-yl)2-(trifluoromethyl) benzonitrile-4,4,4-dimethyl 3-(2-hydroxyethyl) 5-oxo 2-thioxo 1-imidazolidinyl 2-(trifluoromethyl) benzonitrile, 4-(4,4-dimethyl 3-(4-hydroxybutyl) 5-oxo 2-thioxo 1-imidazolidinyl) 2-(trifluoromethyl) benzonitrile-3-(4-cyano 3-trifluoromethyl) phenyl) 5,5-dimethyl 2,4-dioxo 1-dioxo 3-(4-hydroxybutyl) 1- imidazolidinyl) 2-(trifluoromethyl) benzonitrile.
16. A method of inducing anti-androgenic activity in warm-blooded animals comprising administering to warm-blooded animals an anti-androgenically effective amount of at least one compound of claim 1.
17. A method of claim 16 wherein Y is oxygen.
18. A method of claim 16 wherein R.sub.1 is --CN or halogen.
19. A method of claim 16 wherein R.sub.1 is chlorine.
20. A method of claim 14 wherein the active compound is selected from the group consisting of 4-(5-oxo-2-thioxo-3,4,4-trimethyl-1-imidazolidinyl) 2-(trifluoromethyl)-benzonitrile, 4-(4,4-dimethyl-5-oxo-2-thioxo 1-imidazolidinyl)-2-(trifluoromethyl)-benzoitrile, 4-4,4-dimethyl-3-(2-hydroxyethyl) 5-oxo-2-thioxo-1-imidazolidinyl-2-(trifluoromethyl)-benzonitrile, 3-(3,4-dichlorophenyl)-2-thioxo-1,5,5-trimethyl-4-imidazolidinone, 1-(4-nitro-3-(trifluoromethyl)-phenyl-3,4,4-trimethyl-2,5-imidazolidinedio ne, 4-4,5-dihydro4,4-dimethyl-5-oxo-2-(phenylmethyl)-thio-1H-imidazol-1-yl-2-( trifluoromethyl) benzonitrile-4,4,4-dimethyl 3-(2-hydroxyethyl) 5-oxo 2-thioxo 1-imidazolidinyl 2-(trifluoromethyl) benzonitrile, -4-(4,4-dimethyl 3-(4-hydroxybutyl) 5-oxo 2-thioxo 1-imidazolidinyl) 2-(trifluoromethyl) benzonitrile-3-(4-cyano 3-trifluoromethyl) phenyl) 5,5-dimethyl 2,4-dioxo 1-imidazolidinebutanoic and acid and 4-(4,4-dimethyl 2,5-dioxo 3-(4-hydroxybutyl) 1-imidazolidinyl) 2-(trifluoromethyl) benzonitrile.
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Type: Grant
Filed: Feb 27, 1997
Date of Patent: Nov 10, 1998
Assignee: Roussel Uclaf
Inventors: Martine Gaillard-Kelly (Paris), Francois Goubet (Paris), Daniel Phiibert (Laverenne Saint Hiliare), Jean-Georges Teutsch (Pantin)
Primary Examiner: Floyd D. Higel
Law Firm: Bierman, Muserlian and Lucas
Application Number: 8/807,760
International Classification: A61K 31415; C07D23372;
