Interrupted particle source

A synchrocyclotron includes magnetic structures to provide a magnetic field to a cavity, a particle source to provide a plasma column to the cavity, where the particle source has a housing to hold the plasma column, and where the housing is interrupted at an acceleration region to expose the plasma column, and a voltage source to provide a radio frequency (RF) voltage to the cavity to accelerate particles from the plasma column at the acceleration region.

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Description
CROSS-REFERENCE TO RELATED APPLICATION

This patent application a reissue application of U.S. application Ser. No. 14/075,261 filed on Nov. 8, 2013 now U.S. Pat. No. 8,970,137, which is a continuation of U.S. application Ser. No. 11/948,662, which was filed on Nov. 30, 2007 and which is scheduled to issue as now U.S. Pat. No. 8,581,523 on Nov. 12, 2013. The contents of U.S. application Ser. No. 11/948,662 are incorporated herein by reference.

TECHNICAL FIELD

This patent application describes a particle accelerator having a particle source that is interrupted at an acceleration region.

BACKGROUND

In order to accelerate charged particles to high energies, many types of particle accelerators have been developed. One type of particle accelerator is a cyclotron. A cyclotron accelerates charged particles in an axial magnetic field by applying an alternating voltage to one or more dees in a vacuum chamber. The name dee is descriptive of the shape of the electrodes in early cyclotrons, although they may not resemble the letter D in some cyclotrons. The spiral path produced by the accelerating particles is perpendicular to the magnetic field. As the particles spiral out, an accelerating electric field is applied at the gap between the dees. The radio frequency (RF) voltage creates an alternating electric field across the gap between the dees. The RF voltage, and thus the field, is synchronized to the orbital period of the charged particles in the magnetic field so that the particles are accelerated by the radio frequency waveform as they repeatedly cross the gap. The energy of the particles increases to an energy level greatly in excess of the peak voltage of the applied RF voltage. As the charged particles accelerate, their masses grow due to relativistic effects. Consequently, the acceleration of the particles varies the phase match at the gap.

Two types of cyclotrons presently employed, an isochronous cyclotron and a synchrocyclotron, overcome the challenge of increase in relativistic mass of the accelerated particles in different ways. The isochronous cyclotron uses a constant frequency of the voltage with a magnetic field that increases with radius to maintain proper acceleration. The synchrocyclotron uses a decreasing magnetic field with increasing radius to provide axial focusing and varies the frequency of the accelerating voltage to match the mass increase caused by the relativistic velocity of the charged particles.

SUMMARY

In general, this patent application describes a synchrocyclotron comprising magnetic structures to provide a magnetic field to a cavity, and a particle source to provide a plasma column to the cavity. The particle source has a housing to hold the plasma column. The housing is interrupted at an acceleration region to expose the plasma column. A voltage source is configured to provide a radio frequency (RF) voltage to the cavity to accelerate particles from the plasma column at the acceleration region. The synchrocyclotron described above may include one or more of the following features, either alone or in combination.

The magnetic field may be above 2 Tesla (T), and the particles may accelerate from the plasma column outwardly in spirals with radii that progressively increase. The housing may comprise two portions that are completely separated at the acceleration region to expose the plasma column. The voltage source may comprise a first dee that is electrically connected to an alternating voltage and a second dee that is electrically connected to ground. At least part of the particle source may pass through the second dee. The synchrocyclotron may comprise a stop in the acceleration region. The stop may be for blocking acceleration of at least some of the particles from the plasma column. The stop may be substantially orthogonal to the acceleration region and may be configured to block certain phases of particles from the plasma column.

The synchrocyclotron may comprise cathodes for use in generating the plasma column. The cathodes may be operable to pulse a voltage to ionize gas to generate the plasma column. The cathodes may be configured to pulse at voltages between about 1 kV to about 4 kV. The cathodes need not be heated by an external heat source. The synchrocyclotron may comprise a circuit to couple voltage from the RF voltage to the at least one of the cathodes. The circuit may comprise a capacitive circuit.

The magnetic structures may comprise magnetic yokes. The voltage source may comprise a first dee that is electrically connected to an alternating voltage and a second dee that is electrically connected to ground. The first dee and the second dee may form a tunable resonant circuit. The cavity to which the magnetic field is applied may comprise a resonant cavity containing the tunable resonant circuit.

In general, this patent application also describes a particle accelerator comprising a tube containing a gas, a first cathode adjacent to a first end of the tube, and a second cathode adjacent to a second end of the tube. The first and second cathodes are for applying voltage to the tube to form a plasma column from the gas. Particles are available to be drawn from the plasma column for acceleration. A circuit is configured to couple energy from an external radio frequency (RF) field to at least one of the cathodes. The particle accelerator described above may include one or more of the following features, either alone or in combination.

The tube may be interrupted at an acceleration region at which the particles are drawn from the plasma column. The first cathode and the second cathode need not be heated by an external source. The first cathode may be on a different side of the acceleration region than the second cathode.

The particle accelerator may comprise a voltage source to provide the RF field. The RF field may be for accelerating the particles from the plasma column at the acceleration region. The energy may comprise a portion of the RF field provided by the voltage source. The circuit may comprise a capacitor to couple energy from the external field to at least one of the first cathode and the second cathode.

The tube may comprise a first portion and a second portion that are completely separated at a point of interruption at the acceleration region. The particle accelerator may comprise a stop at the acceleration region. The stop may be used to block at least one phase of the particles from further acceleration.

The particle accelerator may comprise a voltage source to provide the RF field to the plasma column. The RF field may be for accelerating the particles from the plasma column at the acceleration region. The RF field may comprise a voltage that is less than 15 kV. Magnetic yokes may be used to provide a magnetic field that crosses the acceleration region. The magnetic field may be greater than about 2 Tesla (T).

In general, this patent application also describes a particle accelerator comprising a Penning ion gauge (PIG) source comprising a first tube portion and a second tube portion that are at least partially separated at an acceleration region. The first tube portion and the second tube portion are for holding a plasma column that extends across the acceleration region. A voltage source is used to provide a voltage at the acceleration region. The voltage is for accelerating particles out of the plasma column at the acceleration region. The particle accelerator described above may include one or more of the following features, either alone or in combination.

The first tube portion and the second tube portion may be completely separated from each other. Alternatively, only one or more portions of the first tube portion may be separated from corresponding portions of the second tube portion. In this latter configuration, the PIG source may comprise a physical connection between a part of the first tube portion and the second tube portion. The physical connection may enable particles accelerating out of the plasma column to complete a first turn upon escaping from the plasma column without running into the physical connection.

The PIG source may pass through a first dee that is electrically connected to ground. A second dee that is electrically connected to an alternating voltage source may provide the voltage at the acceleration region.

The particle accelerator may comprise a structure that substantially encloses the PIG source. The particle accelerator may comprise magnetic yokes that define a cavity containing the acceleration region. The magnetic yokes may be for generating a magnetic field across the acceleration region. The magnetic field may be at least 2 Tesla (T). For example, the magnetic field may be at least 10.5 T. The voltage may comprise a radio frequency (RF) voltage that is less than 15 kV.

The particle accelerator may comprise one or more electrodes for use in accelerating the particles out of the particle accelerator. At least one cathode may be used in generating the plasma column. The at least one cathode used in generating the plasma column may comprise a cold cathode (e.g., one that is not heated by an external source). A capacitive circuit may couple at least some of the voltage to the cold cathode. The cold cathode may be configured to pulse voltage to generate the plasma column from gas in the first tube portion and the second tube portion.

Any of the foregoing features may be combined to form implementations not specifically described herein.

The details of one or more examples are set forth in the accompanying drawings and the description below. Further features, aspects, and advantages will become apparent from the description, the drawings, and the claims.

DESCRIPTION OF THE DRAWINGS

FIG. 1A is a cross-sectional view of a synchrocyclotron.

FIG. 1B is a side cross-sectional view of the synchrocyclotron shown in FIG. 1A.

FIG. 2 is an illustration of an idealized waveform that can be used for accelerating charged particles in the synchrocyclotron of FIGS. 1A and 1B.

FIG. 3A is a side view of a particle source, such as a Penning ion gauge source.

FIG. 3B is a close-up side view of a portion of the particle source of FIG. 3A passing through a dummy dee and adjacent to an RF dee.

FIG. 4 is a side view of the particle source of FIG. 3 showing spiral acceleration of a particle from a plasma column generated by the particle source.

FIG. 5 is a perspective view of the particle source of FIG. 4

FIG. 6 is a perspective view of the particle source of FIG. 4 containing a stop for blocking one or more phases of particles.

FIG. 7 is a perspective view of an alternative embodiment, in which a substantial portion of the ion source is removed.

DETAILED DESCRIPTION

A synchrocyclotron-based system is described herein. However, the circuits and methods described herein may used with any type of cyclotron or particle accelerator.

Referring to FIGS. 1A and 1B, a synchrocyclotron 1 includes electrical coils 2a and 2b around two spaced apart ferro-magnetic poles 4a and 4b, which are configured to generate a magnetic field. Magnetic poles 4a and 4b are defined by two opposing portions of yokes 6a and 6b (shown in cross-section). The space between poles 4a and 4b defines vacuum chamber 8 or a separate vacuum chamber can be installed between poles 4a and 4b. The magnetic field strength is generally a function of distance from the center of vacuum chamber 8 and is determined largely by the choice of geometry of coils 2a and 2b and the shape and material of magnetic poles 4a and 4b.

The accelerating electrodes are defined as dee 10 and dee 12, having gap 13 between them. Dee 10 is connected to an alternating voltage potential whose frequency is changed from high to low during an accelerating cycle in order to account for the increasing relativistic mass of a charged particle and radially decreasing magnetic field (measured from the center of vacuum chamber 8) produced by coils 2a and 2b and pole portions 4a and 4b. Accordingly, dee 10 is referred to as the radio frequency (RF) dee. The idealized profile of the alternating voltage in dees 10 and 12 is show in FIG. 2 and will be discussed in detail below. In this example, RF dee 10 is a half-cylinder structure, which is hollow inside. Dee 12, also referred to as the “dummy dee”, does not need to be a hollow cylindrical structure, since it is grounded at the vacuum chamber walls 14. Dee 12, as shown in FIGS. 1A and 1B, includes a strip of metal, e.g., copper, having a slot shaped to match a substantially similar slot in RF dee 10. Dee 12 can be shaped to form a mirror image of surface 16 of RF dee 10.

Ion source 18 is located at about the center of vacuum chamber 8, and is configured to provide particles (e.g., protons) at a center of the synchrocyclotron for acceleration, as described below. Extraction electrodes 22 direct the charged particles from an acceleration region into extraction channel 24, thereby forming beam 26 of the charged particles. Here, ion source 18 is inserted axially into the acceleration region.

Dees 10 and 12 and other pieces of hardware included in a synchrocyclotron define a tunable resonant circuit under an oscillating voltage input that creates an oscillating electric field across gap 13. The result is a resonant cavity in vacuum chamber 8. This resonant frequency of the resonant cavity can be tuned to keep its Q-factor high by synchronizing the frequency being swept. In one example, the resonant frequency of the resonant cavity moves, or “sweeps”, within a range of about 30 Megahertz (MHz) and about 135 MHz (VHF range) over time, e.g., over about 1 millisecond (ms). In another example, the resonant frequency of the resonant cavity moves, or sweeps, between about 95 MHz and about 135 MHz in about 1 ms. Resonance of the cavity may be controlled in the manner described in U.S. patent application Ser. No. 11/948,359, entitled “Matching A Resonant Frequency Of A Resonant Cavity To A Frequency Of An Input Voltage”, the contents of which are incorporated herein by reference as if set forth in full.

The Q-factor is a measure of the “quality” of a resonant system in its response to frequencies close to the resonant frequency. In this example, the Q-factor is defined as
Q=1/R×√/(L/C),
where R is the active resistance of the resonant circuit, L is the inductance, and C is the capacitance of the resonant circuit.

The tuning mechanism can be, e.g., a variable inductance coil or a variable capacitance. A variable capacitance device can be a vibrating reed or a rotating capacitor. In the example shown in FIGS. 1A and 1B, the tuning mechanism includes rotating capacitor 28. Rotating capacitor 28 includes rotating blades 30 that are driven by a motor 31. During each cycle of motor 31, as blades 30 mesh with blades 32, the capacitance of the resonant circuit that includes dees 10 and 12 and rotating capacitor 28 increases and the resonant frequency decreases. The process reverses as the blades unmesh. Thus, the resonant frequency is changed by changing the capacitance of the resonant circuit. This serves the purpose of reducing, by a large factor, the power required to generate the high voltage applied at the dee/dummy dee gap at the frequency necessary to accelerate the particle beam. The shape of blades 30 and 32 can be machined so as to create the required dependence of resonant frequency on time.

The blade rotation can be synchronized with RF frequency generation so the frequency of the resonant circuit defined by the synchrocyclotron is kept close to the frequency of the alternating voltage potential applied to the resonant cavity. This promotes efficient transformation of applied RF power to RF voltage on the RF dee.

A vacuum pumping system 40 maintains vacuum chamber 8 at a very low pressure so as not to scatter the accelerating beam (or to provide relatively little scattering) and to substantially prevent electrical discharges from the RF dee.

To achieve substantially uniform acceleration in the synchrocyclotron, the frequency and the amplitude of the electric field across the dee gap is varied to account for the relativistic mass increase and radial variation of magnetic field as well as to maintain focus of the beam of particles. The radial variation of the magnetic field is measured as a distance from the center of an outwardly spiraling trajectory of a charged particle.

FIG. 2 is an illustration of an idealized waveform that may be required for accelerating charged particles in a synchrocyclotron. It shows only a few cycles of the waveform and does not necessarily represent the ideal frequency and amplitude modulation profiles. FIG. 2 illustrates the time varying amplitude and frequency properties of the waveform used in the synchrocyclotron. The frequency changes from high to low as the relativistic mass of the particle increases while the particle speed approaches a significant fraction of the speed of light.

Ion source 18 is deployed near to the magnetic center of synchrocyclotron 1 so that particles are present at the synchrocyclotron mid-plane, where they can be acted upon by the RF field (voltage). The ion source may have a Penning ion gauge (PIG) geometry. In the PIG geometry, two high voltage cathodes are placed about opposite each other. For example, one cathode may be on one side of the acceleration region and one cathode may be on the other side of the acceleration region and in line with the magnetic field lines. The dummy dee housings 12 of the source assembly may be at ground potential. The anode includes a tube extending toward the acceleration region. When a relatively small amount of a gas (e.g., hydrogen/H2) occupies a region in the tube between the cathodes, a plasma column may be formed from the gas by applying a voltage to the cathodes. The applied voltage causes electrons to stream along the magnetic field lines, essentially parallel to the tube walls, and to ionize gas molecules that are concentrated inside the tube, thereby creating the plasma column.

A PIG geometry ion source 18, for use in synchrocyclotron 1, is shown in FIGS. 3A and 3B. Referring to FIG. 3A, ion source 18 includes an emitter side 38a containing a gas feed 39 for receiving gas, and a reflector side 38b. A housing, or tube, 44 holds the gas, as described below. FIG. 3B shows ion source 18 passing through dummy dee 12 and adjacent to RF dee 10. In operation, the magnetic field between RF dee 10 and dummy dee 12 causes particles (e.g., protons) to accelerate outwardly. The acceleration is spiral about the plasma column, with the particle-to-plasma-column radius progressively increasing. The spiral acceleration, labeled 43, is depicted in FIGS. 5 and 6. The radii of curvature of the spirals depend on a particle's mass, energy imparted to the particle by the RF field, and a strength of the magnetic field.

When the magnetic field is high, it can become difficult to impart enough energy to a particle so that it has a large enough radius of curvature to clear the physical housing of the ion source on its initial turn(s) during acceleration. The magnetic field is relatively high in the region of the ion source, e.g., on the order of 2 Tesla (T) or more (e.g., 8 T, 8.8 T, 8.9 T, 9 T, 10.5 T, or more). As a result of this relatively high magnetic field, the initial particle-to-ion-source radius is relatively small for low energy particles, where low energy particles include particles that are first drawn from the plasma column. For example, such a radius may be on the order of 1 mm. Because the radii are so small, at least initially, some particles may come into contact with the ion source's housing area, thereby preventing further outward acceleration of such particles. Accordingly, the housing of ion source 18 is interrupted, or separated to form two parts, as shown in FIG. 3B. That is, a portion of the ion source's housing is removed at the acceleration region 41, e.g., at about the point where the particles are to be drawn from the ion source. This interruption is labeled 45 in FIG. 3B. The housing may also be removed for distances above, and below, the acceleration region. All or part of dummy dee 12 at the acceleration region may, or may not, also be removed.

In the example of FIGS. 3A and 3B, the housing 44 includes a tube, which holds a plasma column containing particles to be accelerated. The tube may have different diameters at different points, as shown. The tube may reside within dummy dee 12, although this is not necessary. A portion of the tube in about a median plane of the synchrocyclotron is completely removed, resulting in a housing comprised of two separate portions with an interruption 45 between the portions. In this example, the interruption is about 1 millimeter (mm) to 3 mm (i.e., about 1 mm to 3 mm of the tube is removed). The amount of the tube that is removed may be significant enough to permit particle acceleration from the plasma column, but small enough to hinder significant dissipation of the plasma column in the interrupted portion.

By removing the physical structure, here the tube, at the particle acceleration region, particles can make initial turn(s) at relatively small radii—e.g., in the presence of relatively high magnetic fields—without coming in to contact with physical structures that impede further acceleration. The initial turn(s) may even cross back through the plasma column, depending upon the strength of the magnetic and RF fields.

The tube may have a relatively small interior diameter, e.g., about 2 mm. This leads to a plasma column that is also relatively narrow and, therefore, provides a relatively small set of original radial positions at which the particles can start accelerating. The tube is also sufficiently far from cathodes 46 used to produce the plasma column—in this example, about 10 mm from each cathode. These two features, combined, reduce the amount of hydrogen (H2) gas flow into the synchrocyclotron to less than 1 standard cubic centimeter per minute (SCCM), thereby enabling the synchrocyclotron to operate with relatively small vacuum conductance apertures into the synchrocyclotron RF/beam cavity and relatively small capacity vacuum pump systems, e.g., about 500 liters-per-second.

Interruption of the tube also supports enhanced penetration of the RF field into the plasma column. That is, since there is no physical structure present at the interruption, the RF field can easily reach the plasma column. Furthermore, the interruption in the tube allows particles to be accelerated from the plasma column using different RF fields. For example, lower RF fields may be used to accelerate the particles. This can reduce the power requirements of systems used to generate the RF field. In one example, a 20 kilowatt (kW) RF system generates an RF field of 15 kilovolts (kV) to accelerate particles from the plasma column. The use of lower RF fields reduces RF system cooling requirements and RF voltage standoff requirements.

In the synchrocyclotron described herein, a particle beam is extracted using a resonant extraction system. That is, the amplitude of radial oscillations of the beam are increased by a magnetic perturbation inside the accelerator, which is in resonance with these oscillations. When a resonant extraction system is used, extraction efficiency is improved by limiting the phase space extent of the internal beam. With attention to the design of the magnetic and RF field generating structures, the phase space extent of the beam at extraction is determined by the phase space extent at the beginning of acceleration (e.g., at emergence from the ion source). As a result, relatively little beam may be lost at the entrance to the extraction channel and background radiation from the accelerator can be reduced.

A physical structure, or stop, may be provided to control the phase of the particles that are allowed to escape from the central region of the synchrocyclotron. An example of such a stop 51 is shown in FIG. 6. Stop 51 acts as a obstacle that blocks particles having certain phases. That is, particles that hit the stop are prevented from accelerating further, whereas particles that pass the stop continue their acceleration out of the synchrocyclotron. A stop may be near the plasma column, as shown in FIG. 6, in order to select phases during the initial turn(s) of particles where the particle energy is low, e.g., less than 50 kV. Alternatively, a stop may be located at any other point relative to the plasma column. In the example shown in FIG. 6, a single stop is located on the dummy dee 12. There, however, may be more than one stop (not shown) per dee.

Cathodes 46 may be “cold” cathodes. A cold cathode may be a cathode that is not heated by an external heat source. Also, the cathodes may be pulsed, meaning that they output signal burst(s) periodically rather than continuously. When the cathodes are cold, and are pulsed, the cathodes are less subject to wear and can therefore last relatively long. Furthermore, pulsing the cathodes can eliminate the need to watercool the cathodes. In one implementation, cathodes 46 pulse at a relatively high voltage, e.g., about 1 kV to about 4 kV, and moderate peak cathode discharge currents of about 50 mA to about 200 mA at a duty cycle between about 0.1% and about 1% or 2% at repetition rates between about 200 Hz to about 1 KHz.

Cold cathodes can sometimes cause timing jitter and ignition delay. That is, lack of sufficient heat in the cathodes can affect the time at which electrons are discharged in response to an applied voltage. For example, when the cathodes are not sufficiently heated, the discharge may occur several microseconds later, or longer, than expected. This can affect formation of the plasma column and, thus, operation of the particle accelerator. To counteract these effects, voltage from the RF field in cavity 8 may be coupled to the cathodes. Cathodes 46 are otherwise encased in a metal, which forms a Faraday shield to substantially shield the cathodes from the RF field. In one implementation, a portion of the RF energy may be coupled to the cathodes from the RF field, e.g., about 100V may be coupled to the cathodes from the RF field. FIG. 3B shows an implementation, in which a capacitive circuit 54, here a capacitor, is charged by the RF field and provides voltage to a cathode 46. An RF choke and DC feed may be used to charge the capacitor. A corresponding arrangement (not shown) may be implemented for the other cathode 46. The coupled RF voltage can reduce the timing jitter and reduce the discharge delay to about 100 nanoseconds (ns) or less in some implementations.

An alternative embodiment is shown in FIG. 7. In this embodiment, a substantial portion, but not all, of the PIG source housing is removed, leaving the plasma beam partly exposed. Thus, portions of the PIG housing are separated from their counterpart portions, but there is not complete separation as was the case above. The portion 61 that remains physically connects the first tube portion 62 and the second tube portion 63 of the PIG source. In this embodiment, enough of the housing is removed to enable particles to perform at least one turn (orbit) without impinging on the portion 61 of the housing that remains. In one example, the first turn radius may be 1 mm, although other turn radii may be implemented. The embodiment shown in FIG. 7 may be combined with any of the other features described herein.

The particle source and accompanying features described herein are not limited to use with a synchrocyclotron, but rather may be used with any type of particle accelerator or cyclotron. Furthermore ion sources other than those having a PIG geometry may be used with any type of particle accelerator, and may have interrupted portions, cold cathodes, stops, and/or any of the other features described herein.

Components of different implementations described herein may be combined to form other embodiments not specifically set forth above. Other implementations not specifically described herein are also within the scope of the following claims.

Claims

1. A synchrocyclotron comprising:

magnetic structures to provide a magnetic field to a cavity;
a particle source to provide comprising cathodes for generating a plasma column to in the cavity, the particle source having a housing to hold the plasma column, the housing being interrupted at an acceleration region to expose the plasma column, wherein the housing is interrupted such that the housing is completely separated at the acceleration region or such that a part of the housing is physically connected at the acceleration region; and
a voltage source to provide a radio frequency (RF) voltage to the cavity to accelerate particles from the plasma column at the acceleration region;
wherein, in a case that part of the housing is physically connected, the part of the housing has structure that allows particles accelerated from the plasma column to perform at least one turn without impinging on the part of the housing.

2. The synchrocyclotron of claim 1, wherein the magnetic field is above 2 Tesla (T), and the particles move from the plasma column outwardly in spirals with radii that progressively increase.

3. The synchrocyclotron of claim 1, wherein the housing comprises two portions that are completely separated at the acceleration region to expose the plasma column.

4. The synchrocyclotron of claim 1, wherein the voltage source comprises a first dee that is electrically connected to an alternating voltage and a second dee that is electrically connected to ground; and

wherein at least part of the particle source passes through the second dee.

5. The synchrocyclotron of claim 1, further comprising a stop in the acceleration region, the stop for blocking acceleration of at least some of the particles from the plasma column.

6. The synchrocyclotron of claim 5, wherein the stop is substantially orthogonal to the acceleration region and is configured to block certain phases of particles from the plasma column.

7. The synchrocyclotron of claim 1,further comprising:

cathodes for use in generating the plasma column, wherein the cathodes being are operable to pulse a voltage to ionize gas to generate the plasma column; and
wherein the cathodes are not heated by an external heat source.

8. The synchrocyclotron of claim 7, wherein the cathodes are configured to pulse at voltages between about 1 kV to about 4 kV.

9. The synchrocyclotron of claim 7, further comprising:

a circuit to couple voltage from the RF voltage to the at least one of the cathodes.

10. The synchrocyclotron of claim 9, wherein the circuit comprises a capacitive circuit.

11. The synchrocyclotron of claim 1, wherein the magnetic structures comprise magnetic yokes, wherein the voltage source comprises a first dee that is electrically connected to an alternating voltage and a second dee that is electrically connected to ground, wherein the first dee and the second dee form a tunable resonant circuit, and wherein the cavity comprises a resonant cavity containing the tunable resonant circuit.

12. A synchrocyclotron comprising:

a tube containing a gas;
a first cathode adjacent to a first end of the tube; and
a second cathode adjacent to a second end of the tube, the first and second cathodes applying voltage to the tube to form a plasma column from the gas;
wherein particles are available to be drawn from the plasma column for acceleration; and
a circuit to couple energy from an external a radio frequency (RF) field to at least one of the cathodes;
wherein the tube is interrupted at an acceleration region where the particles are accelerated to expose the plasma column, wherein the tube is interrupted such that the tube is completely separated into two parts at the acceleration region or such that a part of the tube is physically connected at the acceleration region where the particles are accelerated;
wherein, in a case that part of the tube is physically connected, the part of the tube has structure that allows particles accelerated from the plasma column to perform at least one turn without impinging on the part of the tube.

13. The synchrocyclotron of claim 12, wherein the first cathode and the second cathode are not heated by an external source.

14. The synchrocyclotron of claim 13, further comprising:

a voltage source to provide the RF field, the RF field for accelerating the particles from the plasma column at the acceleration region where the particles are accelerated.

15. The synchrocyclotron of claim 14, wherein the energy comprises a portion of the RF field provided by the voltage source.

16. The synchrocyclotron of claim 13, wherein the circuit comprises a capacitor to couple energy from the external RF field to at least one of the first cathode and the second cathode.

17. The synchrocyclotron of claim 13 12, wherein the tube comprises a first portion part and a second portion that are completely separated at the acceleration region where the particles are accelerated part that are separated by a space that is between 1 mm and 3 mm.

18. The synchrocyclotron of claim 13, further comprising:

a stop at the acceleration region, the stop to block at least one phase of the particles from further acceleration.

19. The synchrocyclotron of claim 13 12, further comprising:

a voltage source to provide the RF field to the plasma column, the RF field for accelerating the particles from the plasma column at the acceleration region where the particles are accelerated, wherein the RF field comprises voltage that is less than 15 kV; and
magnetic yokes structures to provide a magnetic field that crosses the acceleration region where the particles are accelerated, the magnetic field being greater than about 2 Tesla (T).

20. The synchrocyclotron of claim 12, wherein the first cathode is on a different side of the acceleration region than the second cathode.

21. A synchrocyclotron comprising:

a Penning ion gauge (PIG) source comprising a first tube portion and a second tube portion, the first tube portion having a first cathode and the second tube portion having a second cathode, the first cathode and the second cathode for holding generating a plasma column that extends across an acceleration region from which particles are accelerated from the plasma column; and
a voltage source to provide a voltage at the acceleration region, the voltage for accelerating particles out of the plasma column at the acceleration region;
wherein the first tube portion is completely separated from the second tube portion at the acceleration region or a connection exists between the first tube portion and the second tube portion at the acceleration region;
wherein, in a case that the connection exists, the connection has structure that allows particles accelerated from the plasma column to perform at least one turn without impinging on the connection.

22. The synchrocyclotron of claim 21, wherein the PIG source comprises a physical connection between a part of the first tube portion and the second tube portion, the physical connection enabling particles accelerating out of the plasma column to complete a first turn upon escaping from the plasma column without running into the physical connection.

23. The synchrocyclotron of claim 21, wherein the PIG source passes through a first dee that is electrically connected to ground, and wherein a second dee that is electrically connected to an alternating voltage source provides the voltage at the acceleration region.

24. The synchrocyclotron of claim 21, further comprising:

magnetic yokes structures that define border a cavity containing the acceleration region, the magnetic yokes structures for generating a magnetic field across the acceleration region.

25. The synchrocyclotron of claim 24, wherein the magnetic field is at least 2 Tesla (T).

26. The synchrocyclotron of claim 25, wherein the magnetic field is at least 10.5 T.

27. The synchrocyclotron of claim 26 21, wherein the voltage comprises a radio frequency (RF) voltage that is less than 15 kV.

28. The synchrocyclotron of claim 21, further comprising one or more electrodes for use in accelerating structures to direct the particles out of the particle accelerator.

29. The synchrocyclotron of claim 21, further comprising:

at least one cathode for use in generating the plasma column, the at least one cathode comprising wherein the first cathode comprises a cold cathode and the second cathode comprises a cold cathode; and
a capacitive circuit to couple at least some of the voltage to the at least one cathode.

30. The synchrocyclotron of claim 21, wherein the at least one cathode is first cathode and the second cathode are configured to pulse voltage to generate the plasma column from gas in the first tube portion and the second tube portion.

31. A particle accelerator comprising:

a tube containing a gas;
a first cathode adjacent to a first end of the tube;
a second cathode adjacent to a second end of the tube, the first and second cathodes applying voltage to the tube to form a plasma column from the gas;
wherein particles are available to be drawn from the plasma column for acceleration;
a circuit to couple energy from an external a radio frequency (RF) field to at least one of the cathodes; and
magnetic structures to provide a magnetic field that crosses an acceleration region where the particles are accelerated, the magnetic field being greater than about 2 Tesla (T);
wherein the tube is interrupted at the acceleration region where the particles are accelerated to expose the plasma column, and wherein the tube is interrupted such that the tube is completely separated into two parts at the acceleration region or such that a part of the tube is physically connected at the acceleration region where the particles are accelerated;
wherein, in a case that part of the tube is physically connected, the part of the tube has structure that allows particles accelerated from the plasma column to perform at least one turn without impinging on the part of the tube.

32. The particle accelerator of claim 31, wherein the first cathode and the second cathode are not heated by an external source.

33. The particle accelerator of claim 32, wherein the circuit comprises a capacitor to couple energy from the external RF field to at least one of the first cathode and the second cathode.

34. The particle accelerator of claim 32, wherein the tube comprises a first portion and a second portion that are completely separated at the acceleration region where the particles are accelerated.

35. The particle accelerator of claim 32 31, further comprising:

a stop at the acceleration region where the particles are accelerated, the stop to block at least one phase of the particles from further acceleration.

36. The particle accelerator of claim 32 31, further comprising:

a voltage source to provide the RF field to the plasma column, the RF field for accelerating the particles from the plasma column at the acceleration region where the particles are accelerated, wherein the RF field comprises voltage that is less than 15 kV; and
where wherein the magnetic structures comprise magnetic yokes.

37. The particle accelerator of claim 31, wherein the first cathode is on a different side of the acceleration region where the particles are accelerated than the second cathode.

38. The particle accelerator of claim 37, further comprising:

a voltage source to provide the RF field, the RF field for accelerating the particles from the plasma column at the acceleration region where the particles are accelerated.

39. The particle accelerator of claim 33, wherein the energy comprises a portion of the RF field provided by the voltage source.

40. The particle accelerator of claim 31, wherein the magnetic field is greater than 8 T.

41. The particle accelerator of claim 31, wherein the magnetic field is greater than 10.5 T.

42. A synchrocyclotron comprising:

ferromagnetic pole pieces that border a cavity containing an acceleration region;
electrical coils adjacent to the ferromagnetic pole pieces to produce a magnetic field of at least 2 Tesla (T) within the cavity; and
a Penning ion gauge (PIG) source comprised of a first part and a second part that are completely separated at the acceleration region to allow extraction of charged particles from a plasma column for acceleration, the first part having a first cathode and the second part having a second cathode, the first cathode and the second cathode for generating the plasma column.

43. The synchrocyclotron of claim 42, wherein the magnetic field is at least 8 T.

44. The synchrocyclotron of claim 42, further comprising:

a voltage system to provide radio frequency (RF) voltage to the cavity, the voltage system comprising a first dee that is electrically connected to an alternating voltage and a second dee that is electrically connected to ground;
wherein at least part of the PIG source passes through the second dee.

45. A synchrocyclotron comprising:

ferromagnetic pole pieces that border a cavity containing an acceleration region;
electrical coils adjacent to the ferromagnetic pole pieces to produce a magnetic field of at least 2 Tesla (T) within the cavity;
a Penning ion gauge (PIG) source comprised of a first part and a second part that are completely separated at the acceleration region to allow extraction of charged particles from a plasma column for acceleration; and
a stop in the acceleration region, the stop for blocking at least some of the charged particles.

46. The synchrocyclotron of claim 45, wherein the stop is substantially orthogonal to the acceleration region and is configured to block certain phases of the charged particles.

47. The synchrocyclotron of claim 42, wherein the first cathode and the second cathode are operable to pulse a voltage to ionize gas to generate the plasma column; and

wherein the first and second cathodes are not heated by an external heat source.

48. The synchrocyclotron of claim 47, wherein the first and second cathodes are controllable to pulse at voltages between about 1 kV to about 4 kV.

49. The synchrocyclotron of claim 48, further comprising:

a circuit to couple voltage to at least one of the first and second cathodes.

50. The synchrocyclotron of claim 49, wherein the circuit comprises a capacitive circuit.

51. A synchrocyclotron comprising:

ferromagnetic pole pieces that border a cavity containing an acceleration region in which charged particles are accelerated, the cavity containing a magnetic field of at least 2 Tesla (T);
a particle source comprising a first part and a second part, the first part having a first cathode and the second part having a second cathode, the first part and the second part being completely separated at the acceleration region;
accelerating electrodes to provide a radio frequency (RF) voltage to the acceleration region to extract the charged particles, the RF voltage sweeping over a frequency range; and
circuitry to couple energy from the RF voltage to at least one of the first cathode or the second cathode.

52. The synchrocyclotron of claim 51, wherein the cavity contains a magnetic field that is at least 8 T.

53. The synchrocyclotron of claim 51, wherein the cavity contains a magnetic field that is at least 10.5 T.

54. The synchrocyclotron of claim 51, further comprising:

a voltage system to provide radio frequency (RF) voltage to the cavity, the voltage system comprising a first dee that is electrically connected to an alternating voltage and a second dee that is electrically connected to ground;
wherein at least part of the particle source passes through the second dee.

55. The synchrocyclotron of claim 51, further comprising a stop in the acceleration region, the stop for blocking at least some of the charged particles.

56. The synchrocyclotron of claim 55, wherein the stop is substantially orthogonal to the acceleration region and is configured to block certain phases of the charged particles.

57. The synchrocyclotron of claim 51, wherein the first and second cathodes are controllable to pulse at voltages between about 1 kV to about 4 kV.

58. The synchrocyclotron of claim 51, wherein the circuitry comprises a capacitive circuit.

59. A synchrocyclotron comprising:

ferromagnetic pole pieces that border a cavity containing an acceleration region;
a voltage system to provide radio frequency (RF) voltage to the cavity,
electrical coils around part of the ferromagnetic pole pieces to produce a magnetic field having a magnitude of at least 2 Tesla (T) within the cavity; and
a particle source that is completely separated at least at the acceleration region to allow extraction of charged particles from a plasma column for acceleration in response to the RF voltage, the particle source comprising a first part and a second part, the first part having a first cathode and the second part having a second cathode, the first and second cathodes for generating the plasma column.

60. The synchrocyclotron of claim 59, wherein the magnetic field is at least 8 T within the cavity.

61. The synchrocyclotron of claim 59, wherein the voltage system comprises a first dee that is electrically connected to an alternating voltage and a second dee that is electrically connected to ground; and

wherein the RF voltage provided to the cavity is less than 15 kV.

62. The synchrocyclotron of claim 59, wherein the first part and the second part are separated for distances above and below the acceleration region.

63. The synchrocyclotron of claim 59, wherein the plasma column is produced from a gas, and wherein flow of the gas into the synchrocyclotron is less than one standard cubic centimeter per minute (SCCM).

64. A synchrocyclotron comprising:

ferromagnetic pole pieces that border a cavity containing an acceleration region;
a voltage system to provide radio frequency (RF) voltage to the cavity,
electrical coils around part of the ferromagnetic pole pieces to produce a magnetic field having a magnitude of at least 2 Tesla (T) within the cavity;
a particle source that is interrupted at least at the acceleration region to allow extraction of charged particles from a plasma column for acceleration in response to the RF voltage; and
one or more stops at the acceleration region, the one or more stops to block at least one phase of the charged particles extracted from the particle source from further acceleration.
Referenced Cited
U.S. Patent Documents
2280606 April 1942 Roberts
2492324 December 1949 Salisbury
2615129 October 1952 Mcmillan
2659000 November 1953 Salisbury
3175131 March 1965 Burleigh et al.
3432721 March 1969 Naydan et al.
3582650 June 1971 Avery
3679899 July 1972 Dimeff
3689847 September 1972 Verster
3757118 September 1973 Hodge et al.
3868522 February 1975 Bigham et al.
3886367 May 1975 Castle, Jr.
3925676 December 1975 Bigham et al.
2958327 May 1976 Marancik et al.
3955089 May 4, 1976 McIntyre et al.
3958327 May 25, 1976 Marancik et al.
3992625 November 16, 1976 Schmidt et al.
4038622 July 26, 1977 Purcell
4047068 September 6, 1977 Ress et al.
4112306 September 5, 1978 Nunan
4129784 December 12, 1978 Tschunt et al.
4139777 February 13, 1979 Rautenbach
4197510 April 8, 1980 Szu
4220866 September 2, 1980 Symmons et al.
4230129 October 28, 1980 LeVeen
4256966 March 17, 1981 Heinz
4293772 October 6, 1981 Stieber
4336505 June 22, 1982 Meyer
4342060 July 27, 1982 Gibson
4345210 August 17, 1982 Tran
4353033 October 5, 1982 Karasawa
4425506 January 10, 1984 Brown et al.
4490616 December 25, 1984 Cipollina et al.
4507614 March 26, 1985 Prono et al.
4507616 March 26, 1985 Blosser et al.
4589126 May 13, 1986 Augustsson et al.
4598208 July 1, 1986 Brunelli et al.
4628523 December 9, 1986 Heflin
4633125 December 30, 1986 Blosser et al.
4641057 February 3, 1987 Blosser et al.
4641104 February 3, 1987 Blosser et al.
4651007 March 17, 1987 Perusek et al.
4680565 July 14, 1987 Jahnke
4705955 November 10, 1987 Mileikowsky
4710722 December 1, 1987 Jahnke
4726046 February 16, 1988 Nunan
4727293 February 23, 1988 Asmussen
4734653 March 29, 1988 Jahnke
4736173 April 5, 1988 Basil, Jr. et al.
4737727 April 12, 1988 Yamada et al.
4739173 April 19, 1988 Blosser et al.
4745367 May 17, 1988 Dustmann et al.
4754147 June 28, 1988 Maughan et al.
4763483 August 16, 1988 Olsen
4767930 August 30, 1988 Stieber et al.
4769623 September 6, 1988 Marsing et al.
4771208 September 13, 1988 Jongen et al.
4783634 November 8, 1988 Yamamoto et al.
4808941 February 28, 1989 Marsing
4812658 March 14, 1989 Koehler
4843333 June 27, 1989 Marsing et al.
4845371 July 4, 1989 Stieber
4865284 September 12, 1989 Gosis et al.
4868843 September 19, 1989 Nunan
4868844 September 19, 1989 Nunan
4870287 September 26, 1989 Cole et al.
4880985 November 14, 1989 Jones
4894541 January 16, 1990 Ono
4902993 February 20, 1990 Krevet
4904949 February 27, 1990 Wilson
4905267 February 27, 1990 Miller et al.
4917344 April 17, 1990 Prechter et al.
4931698 June 5, 1990 Yoshida
4943781 July 24, 1990 Wilson et al.
4945478 July 31, 1990 Merickel et al.
4968915 November 6, 1990 Wilson et al.
4987309 January 22, 1991 Klasen et al.
4996496 February 26, 1991 Kitamura et al.
5006759 April 9, 1991 Krispel
5010562 April 23, 1991 Hernandez et al.
5012111 April 30, 1991 Ueda
5017789 May 21, 1991 Young et al.
5017882 May 21, 1991 Finlan
5036290 July 30, 1991 Sonobe et al.
5039057 August 13, 1991 Prechter et al.
5039867 August 13, 1991 Nishihara et al.
5046078 September 3, 1991 Hernandez et al.
5072123 December 10, 1991 Johnsen
5111042 May 5, 1992 Sullivan et al.
5111173 May 5, 1992 Matsuda et al.
5117194 May 26, 1992 Nakanishi et al.
5117212 May 26, 1992 Yamamoto et al.
5117829 June 2, 1992 Miller et al.
5148032 September 15, 1992 Hernandez
5166531 November 24, 1992 Huntzinger
5189687 February 23, 1993 Bova et al.
5240218 August 31, 1993 Dye
5260579 November 9, 1993 Yasuda et al.
5260581 November 9, 1993 Lesyna et al.
5278533 January 11, 1994 Kawaguchi
5285166 February 8, 1994 Hiramoto et al.
5317164 May 31, 1994 Kurokawa
5336891 August 9, 1994 Crewe
5341104 August 23, 1994 Anton et al.
5349198 September 20, 1994 Takanaka
5365742 November 22, 1994 Boffito et al.
5374913 December 20, 1994 Pissantezky et al.
5382914 January 17, 1995 Hamm et al.
5401973 March 28, 1995 McKeown et al.
5405235 April 11, 1995 Lebre et al.
5434420 July 18, 1995 McKeown et al.
5440133 August 8, 1995 Moyers et al.
5451794 September 19, 1995 McKeown et al.
5461773 October 31, 1995 Kawaguchi
5463291 October 31, 1995 Carroll et al.
5464411 November 7, 1995 Schulte et al.
5492922 February 20, 1996 Palkowitz
5511549 April 30, 1996 Legg et al.
5521469 May 28, 1996 Laisne
5538942 July 23, 1996 Koyama et al.
5549616 August 27, 1996 Schulte et al.
5561697 October 1, 1996 Takafuji et al.
5585642 December 17, 1996 Britton et al.
5633747 May 27, 1997 Nikoonahad
5635721 June 3, 1997 Bardi et al.
5668371 September 16, 1997 Deasy et al.
5672878 September 30, 1997 Yao
5691679 November 25, 1997 Ackermann et al.
5726448 March 10, 1998 Smith et al.
5727554 March 17, 1998 Kalend et al.
5730745 March 24, 1998 Schulte et al.
5751781 May 12, 1998 Brown et al.
5778047 July 7, 1998 Mansfield et al.
5783914 July 21, 1998 Hiramoto et al.
5784431 July 21, 1998 Kalend et al.
5797924 August 25, 1998 Schulte et al.
5811944 September 22, 1998 Sampayan et al.
5818058 October 6, 1998 Nakanishi et al.
5821705 October 13, 1998 Caporaso et al.
5825845 October 20, 1998 Blair et al.
5841237 November 24, 1998 Alton
5846043 December 8, 1998 Spath
5851182 December 22, 1998 Sahadevan
5866912 February 2, 1999 Slater et al.
5874811 February 23, 1999 Finlan et al.
5895926 April 20, 1999 Britton et al.
5920601 July 6, 1999 Nigg et al.
5929458 July 27, 1999 Nemezawa et al.
5963615 October 5, 1999 Egley et al.
5993373 November 30, 1999 Nonaka et al.
6008499 December 28, 1999 Hiramoto et al.
6034377 March 7, 2000 Pu
6057655 May 2, 2000 Jongen
6061426 May 9, 2000 Linders et al.
6064807 May 16, 2000 Arai et al.
6066851 May 23, 2000 Madono et al.
6080992 June 27, 2000 Nonaka et al.
6087670 July 11, 2000 Hiramoto et al.
6094760 August 1, 2000 Nonaka et al.
6118848 September 12, 2000 Reiffel
6140021 October 31, 2000 Nakasuji et al.
6144875 November 7, 2000 Schweikard et al.
6158708 December 12, 2000 Egley et al.
6207952 March 27, 2001 Kan et al.
6219403 April 17, 2001 Nishihara
6222905 April 24, 2001 Yoda et al.
6241671 June 5, 2001 Ritter et al.
6246066 June 12, 2001 Yuehu
6256591 July 3, 2001 Yoda et al.
6265837 July 24, 2001 Akiyama et al.
6268610 July 31, 2001 Pu
6278239 August 21, 2001 Caporaso et al.
6279579 August 28, 2001 Riaziat et al.
6307914 October 23, 2001 Kunieda et al.
6316776 November 13, 2001 Hiramoto et al.
6366021 April 2, 2002 Meddaugh et al.
6368678 April 9, 2002 Bluck
6369585 April 9, 2002 Yao
6380545 April 30, 2002 Yan
6407505 June 18, 2002 Bertsche
6417634 July 9, 2002 Bergstrom
6433336 August 13, 2002 Jongen et al.
6433349 August 13, 2002 Akiyama et al.
6433494 August 13, 2002 Kulish et al.
6441569 August 27, 2002 Janzow
6443349 September 3, 2002 Van Der Burg
6465957 October 15, 2002 Whitham et al.
6472834 October 29, 2002 Hiramoto et al.
6476403 November 5, 2002 Dolinskii et al.
6492922 December 10, 2002 New
6493424 December 10, 2002 Whitham
6498444 December 24, 2002 Hanna et al.
6501981 December 31, 2002 Schweikard et al.
6519316 February 11, 2003 Collins
6593696 July 15, 2003 Ding et al.
6594336 July 15, 2003 Nishizawa et al.
6600164 July 29, 2003 Badura et al.
6617598 September 9, 2003 Matsuda
6621889 September 16, 2003 Mostafavi
6627875 September 30, 2003 Afeyan
6639234 October 28, 2003 Badura et al.
6646383 November 11, 2003 Bertsche et al.
6670618 December 30, 2003 Hartmann et al.
6683318 January 27, 2004 Haberer et al.
6683426 January 27, 2004 Kleeven
6693283 February 17, 2004 Eickhoff et al.
6710362 March 23, 2004 Kraft et al.
6713773 March 30, 2004 Lyons et al.
6713976 March 30, 2004 Zumoto et al.
6717162 April 6, 2004 Jongen
6736831 May 18, 2004 Hartmann et al.
6745072 June 1, 2004 Badura et al.
6769806 August 3, 2004 Moyers
6774383 August 10, 2004 Norimine et al.
6777689 August 17, 2004 Nelson
6777700 August 17, 2004 Yanagisawa et al.
6780149 August 24, 2004 Schulte
6799068 September 28, 2004 Hartmann et al.
6800866 October 5, 2004 Amemiya et al.
6803585 October 12, 2004 Glukhoy et al.
6803591 October 12, 2004 Muramatsu et al.
6814694 November 9, 2004 Pedroni
6822244 November 23, 2004 Beloussov et al.
6853142 February 8, 2005 Chistyakov
6853703 February 8, 2005 Svatos et al.
6864770 March 8, 2005 Nemoto et al.
6865254 March 8, 2005 Nafstadius
6873123 March 29, 2005 Marchand et al.
6891177 May 10, 2005 Kraft et al.
6891924 May 10, 2005 Yoda et al.
6894300 May 17, 2005 Reimoser et al.
6897451 May 24, 2005 Kaercher et al.
6914396 July 5, 2005 Symons et al.
6936832 August 30, 2005 Norimine et al.
6953943 October 11, 2005 Yanagisawa et al.
6965116 November 15, 2005 Wagner et al.
6969194 November 29, 2005 Nafstadius
6979832 December 27, 2005 Yanagisawa et al.
6984835 January 10, 2006 Harada
6992312 January 31, 2006 Yanagisawa et al.
6993112 January 31, 2006 Hesse
7008105 March 7, 2006 Amann et al.
7011447 March 14, 2006 Moyers
7012267 March 14, 2006 Moriyama et al.
7014361 March 21, 2006 Ein-Gal
7026636 April 11, 2006 Yanagisawa et al.
7041479 May 9, 2006 Swartz et al.
7045781 May 16, 2006 Adamec et al.
7049613 May 23, 2006 Yanagisawa et al.
7053389 May 30, 2006 Yanagisawa et al.
7054801 May 30, 2006 Sakamoto et al.
7060997 June 13, 2006 Norimine et al.
7071479 July 4, 2006 Yanagisawa et al.
7073508 July 11, 2006 Moyers
7081619 July 25, 2006 Bashkirov et al.
7084410 August 1, 2006 Beloussov et al.
7091478 August 15, 2006 Haberer
7102144 September 5, 2006 Matsuda et al.
7122811 October 17, 2006 Matsuda et al.
7122966 October 17, 2006 Norling et al.
7122978 October 17, 2006 Nakanishi et al.
7135678 November 14, 2006 Wang et al.
7138771 November 21, 2006 Bechthold et al.
7154107 December 26, 2006 Yanagisawa et al.
7154108 December 26, 2006 Tadokoro et al.
7154991 December 26, 2006 Earnst et al.
7162005 January 9, 2007 Bjorkholm
7173264 February 6, 2007 Moriyama et al.
7173265 February 6, 2007 Miller et al.
7173385 February 6, 2007 Caporaso et al.
7186991 March 6, 2007 Kato et al.
7193227 March 20, 2007 Hiramoto et al.
7199382 April 3, 2007 Rigney et al.
7208748 April 24, 2007 Sliski et al.
7212608 May 1, 2007 Nagamine et al.
7212609 May 1, 2007 Nagamine et al.
7221733 May 22, 2007 Takai et al.
7227161 June 5, 2007 Matsuda et al.
7247869 July 24, 2007 Tadokoro et al.
7257191 August 14, 2007 Sommer
7259529 August 21, 2007 Tanaka
7262424 August 28, 2007 Moriyama et al.
7274018 September 25, 2007 Adamec et al.
7280633 October 9, 2007 Cheng et al.
7295649 November 13, 2007 Johnsen
7297967 November 20, 2007 Yanagisawa et al.
7301162 November 27, 2007 Matsuda et al.
7307264 December 11, 2007 Brusasco et al.
7318805 January 15, 2008 Schweikard et al.
7319231 January 15, 2008 Moriyama et al.
7319336 January 15, 2008 Baur et al.
7331713 February 19, 2008 Moyers
7332880 February 19, 2008 Ina et al.
7345291 March 18, 2008 Kats
7345292 March 18, 2008 Moriyama et al.
7348557 March 25, 2008 Armit
7348579 March 25, 2008 Pedroni
7351988 April 1, 2008 Naumann et al.
7355189 April 8, 2008 Yanagisawa et al.
7361607 April 22, 2008 Yamaguchi
7368740 May 6, 2008 Beloussov et al.
7372053 May 13, 2008 Yamashita et al.
7378672 May 27, 2008 Harada
7381979 June 3, 2008 Yamashita et al.
7397054 July 8, 2008 Natori et al.
7397901 July 8, 2008 Johnsen
7398309 July 8, 2008 Baumann et al.
7402822 July 22, 2008 Guertin et al.
7402823 July 22, 2008 Guertin et al.
7402824 July 22, 2008 Guertin et al.
7402963 July 22, 2008 Sliski
7405407 July 29, 2008 Hiramoto et al.
7425717 September 16, 2008 Matsuda et al.
7432516 October 7, 2008 Peggs et al.
7439528 October 21, 2008 Nishiuchi et al.
7446328 November 4, 2008 Rigney et al.
7446490 November 4, 2008 Jongen et al.
7449701 November 11, 2008 Fujimaki et al.
7453076 November 18, 2008 Welch et al.
7465944 December 16, 2008 Ueno et al.
7466085 December 16, 2008 Nutt
7468506 December 23, 2008 Rogers et al.
7473913 January 6, 2009 Hermann et al.
7476867 January 13, 2009 Fritsch et al.
7476883 January 13, 2009 Nutt
7482606 January 27, 2009 Groezinger et al.
7492556 February 17, 2009 Atkins et al.
7507975 March 24, 2009 Mohr
7525104 April 28, 2009 Harada
7541905 June 2, 2009 Antaya
7547901 June 16, 2009 Guertin et al.
7554096 June 30, 2009 Ward et al.
7554097 June 30, 2009 Ward et al.
7555103 June 30, 2009 Johnsen
7557358 July 7, 2009 Ward et al.
7557359 July 7, 2009 Ward et al.
7557360 July 7, 2009 Ward et al.
7557361 July 7, 2009 Ward et al.
7560715 July 14, 2009 Pedroni
7560717 July 14, 2009 Matsuda et al.
7567694 July 28, 2009 Lu et al.
7574251 August 11, 2009 Lu et al.
7576499 August 18, 2009 Caporaso et al.
7579603 August 25, 2009 Birgy et al.
7579610 August 25, 2009 Grozinger et al.
7582866 September 1, 2009 Furuhashi et al.
7582885 September 1, 2009 Katagiri et al.
7582886 September 1, 2009 Trbojevic
7586112 September 8, 2009 Chiba et al.
7598497 October 6, 2009 Yamamoto et al.
7609009 October 27, 2009 Tanaka et al.
7609809 October 27, 2009 Kapatoes et al.
7609811 October 27, 2009 Siljamaki et al.
7615942 November 10, 2009 Sanders et al.
7626347 December 1, 2009 Sliski
7629598 December 8, 2009 Harada
7639853 December 29, 2009 Olivera et al.
7639854 December 29, 2009 Schnarr et al.
7643661 January 5, 2010 Ruchala et al.
7656258 February 2, 2010 Antaya et al.
7659521 February 9, 2010 Pedroni
7659528 February 9, 2010 Uematsu
7668291 February 23, 2010 Nord et al.
7672429 March 2, 2010 Urano et al.
7679073 March 16, 2010 Urano et al.
7682078 March 23, 2010 Rietzel
7692166 April 6, 2010 Muraki et al.
7692168 April 6, 2010 Moriyama et al.
7696499 April 13, 2010 Miller et al.
7696847 April 13, 2010 Antaya
7701677 April 20, 2010 Schultz et al.
7709818 May 4, 2010 Matsuda et al.
7710051 May 4, 2010 Caporaso et al.
7718982 May 18, 2010 Sliski
7728311 June 1, 2010 Gall
7746978 June 29, 2010 Cheng et al.
7755305 July 13, 2010 Umezawa et al.
7759642 July 20, 2010 Nir
7763867 July 27, 2010 Birgy et al.
7767988 August 3, 2010 Kaiser et al.
7770231 August 3, 2010 Prater et al.
7772577 August 10, 2010 Saito et al.
7773723 August 10, 2010 Nord et al.
7773788 August 10, 2010 Lu et al.
7778488 August 17, 2010 Nord et al.
7783010 August 24, 2010 Clayton
7784127 August 31, 2010 Kuro et al.
7786442 August 31, 2010 Norling
7786451 August 31, 2010 Ward et al.
7786452 August 31, 2010 Ward et al.
7789560 September 7, 2010 Moyers
7791051 September 7, 2010 Beloussov et al.
7796731 September 14, 2010 Nord et al.
7801269 September 21, 2010 Cravens et al.
7801270 September 21, 2010 Nord et al.
7801988 September 21, 2010 Baumann et al.
7807982 October 5, 2010 Nishiuchi et al.
7809107 October 5, 2010 Nord et al.
7812319 October 12, 2010 Diehl et al.
7812326 October 12, 2010 Grozinger et al.
7816657 October 19, 2010 Hansmann et al.
7817778 October 19, 2010 Nord et al.
7817836 October 19, 2010 Chao et al.
7834334 November 16, 2010 Grozinger et al.
7834336 November 16, 2010 Boeh et al.
7835494 November 16, 2010 Nord et al.
7835502 November 16, 2010 Spence et al.
7839972 November 23, 2010 Ruchala et al.
7839973 November 23, 2010 Nord et al.
7848488 December 7, 2010 Mansfield
7857756 December 28, 2010 Warren et al.
7860216 December 28, 2010 Jongen et al.
7860550 December 28, 2010 Saracen et al.
7868301 January 11, 2011 Diehl
7875861 January 25, 2011 Huttenberger et al.
7875868 January 25, 2011 Moriyama et al.
7881431 February 1, 2011 Aoi et al.
7894574 February 22, 2011 Nord et al.
7906769 March 15, 2011 Blasche et al.
7914734 March 29, 2011 Livingston
7919765 April 5, 2011 Timmer
7920040 April 5, 2011 Antaya et al.
7920675 April 5, 2011 Lomax et al.
7928415 April 19, 2011 Bert et al.
7934869 May 3, 2011 Ivanov et al.
7940881 May 10, 2011 Jongen et al.
7943913 May 17, 2011 Balakin
7947969 May 24, 2011 Pu
7949096 May 24, 2011 Cheng et al.
7950587 May 31, 2011 Henson et al.
7960710 June 14, 2011 Kruip et al.
7961844 June 14, 2011 Takeda et al.
7977648 July 12, 2011 Westerly et al.
7977656 July 12, 2011 Fujimaki et al.
7982198 July 19, 2011 Nishiuchi et al.
7982416 July 19, 2011 Tanaka et al.
7984715 July 26, 2011 Moyers
7986768 July 26, 2011 Nord et al.
7987053 July 26, 2011 Schaffner
7989785 August 2, 2011 Emhofer et al.
7990524 August 2, 2011 Jureller et al.
7997553 August 16, 2011 Sloan et al.
8002466 August 23, 2011 Von Neubeck et al.
8003964 August 23, 2011 Stark et al.
8009803 August 30, 2011 Nord et al.
8009804 August 30, 2011 Siljamaki et al.
8039822 October 18, 2011 Rietzel
8041006 October 18, 2011 Boyden et al.
8044364 October 25, 2011 Yamamoto
8049187 November 1, 2011 Tachikawa
8053508 November 8, 2011 Korkut et al.
8053739 November 8, 2011 Rietzel
8053745 November 8, 2011 Moore
8053746 November 8, 2011 Timmer et al.
8067748 November 29, 2011 Balakin
8069675 December 6, 2011 Radovinsky et al.
8071966 December 6, 2011 Kaiser et al.
8080801 December 20, 2011 Safai
8085899 December 27, 2011 Nord et al.
8089054 January 3, 2012 Balakin
8093564 January 10, 2012 Balakin
8093568 January 10, 2012 Mackie et al.
8111125 February 7, 2012 Antaya et al.
8129699 March 6, 2012 Balakin
8144832 March 27, 2012 Balakin
8173981 May 8, 2012 Trbojevic
8188688 May 29, 2012 Balakin
8198607 June 12, 2012 Balakin
8222613 July 17, 2012 Tajiri et al.
8227768 July 24, 2012 Smick et al.
8232536 July 31, 2012 Harada
8288742 October 16, 2012 Balakin
8291717 October 23, 2012 Radovinsky et al.
8294127 October 23, 2012 Tachibana
8304725 November 6, 2012 Komuro et al.
8304750 November 6, 2012 Preikszas et al.
8309941 November 13, 2012 Balakin
8330132 December 11, 2012 Guertin et al.
8334520 December 18, 2012 Otaka et al.
8335397 December 18, 2012 Takane et al.
8344340 January 1, 2013 Gall
8350214 January 8, 2013 Otaki et al.
8368038 February 5, 2013 Balakin
8368043 February 5, 2013 Havelange et al.
8373143 February 12, 2013 Balakin
8373145 February 12, 2013 Balakin
8378299 February 19, 2013 Frosien
8378321 February 19, 2013 Balakin
8382943 February 26, 2013 Clark
8389949 March 5, 2013 Harada et al.
8399866 March 19, 2013 Balakin
8405042 March 26, 2013 Honda et al.
8405056 March 26, 2013 Amaldi et al.
8415643 April 9, 2013 Balakin
8416918 April 9, 2013 Nord et al.
8421041 April 16, 2013 Balakin
8426833 April 23, 2013 Trbojevic
8436323 May 7, 2013 Iseki et al.
8440987 May 14, 2013 Stephani et al.
8445872 May 21, 2013 Behrens et al.
8466441 June 18, 2013 Iwata et al.
8472583 June 25, 2013 Star-Lack et al.
8483357 July 9, 2013 Siljamaki et al.
8487278 July 16, 2013 Balakin
8552406 October 8, 2013 Phaneuf et al.
8552408 October 8, 2013 Hanawa et al.
8569717 October 29, 2013 Balakin
8581215 November 12, 2013 Balakin
8581523 November 12, 2013 Gall et al.
8653314 February 18, 2014 Pelati et al.
8653473 February 18, 2014 Yajima
8952634 February 10, 2015 Sliski
20020172317 November 21, 2002 Maksimchuk et al.
20030048080 March 13, 2003 Amemiya et al.
20030125622 July 3, 2003 Schweikard et al.
20030136924 July 24, 2003 Kraft et al.
20030152197 August 14, 2003 Moyers
20030163015 August 28, 2003 Yanagisawa et al.
20030183779 October 2, 2003 Norimine et al.
20030234369 December 25, 2003 Glukhoy
20040000650 January 1, 2004 Yanagisawa et al.
20040017888 January 29, 2004 Seppi et al.
20040056212 March 25, 2004 Yanagisawa et al.
20040061077 April 1, 2004 Muramatsu et al.
20040061078 April 1, 2004 Muramatsu et al.
20040085023 May 6, 2004 Chistyakov
20040098445 May 20, 2004 Baumann et al.
20040111134 June 10, 2004 Muramatsu et al.
20040118081 June 24, 2004 Reimoser et al.
20040149934 August 5, 2004 Yanagisawa et al.
20040159795 August 19, 2004 Kaercher et al.
20040173763 September 9, 2004 Moriyama et al.
20040174958 September 9, 2004 Moriyama et al.
20040183033 September 23, 2004 Moriyama et al.
20040183035 September 23, 2004 Yanagisawa et al.
20040200982 October 14, 2004 Moriyama et al.
20040200983 October 14, 2004 Fujimaki et al.
20040213381 October 28, 2004 Harada
20040227104 November 18, 2004 Matsuda et al.
20040232356 November 25, 2004 Norimine et al.
20040240626 December 2, 2004 Moyers
20050058245 March 17, 2005 Ein-Gal
20050089141 April 28, 2005 Brown
20050161618 July 28, 2005 Pedroni
20050184686 August 25, 2005 Caporaso et al.
20050228255 October 13, 2005 Saracen et al.
20050234327 October 20, 2005 Saracen et al.
20050247890 November 10, 2005 Norimine et al.
20060017015 January 26, 2006 Sliski et al.
20060067468 March 30, 2006 Rietzel
20060126792 June 15, 2006 Li
20060145088 July 6, 2006 Ma
20060175991 August 10, 2006 Fujisawa
20060284562 December 21, 2006 Hruby et al.
20070001128 January 4, 2007 Sliski et al.
20070013273 January 18, 2007 Albert et al.
20070014654 January 18, 2007 Haverfield et al.
20070023699 February 1, 2007 Yamashita et al.
20070029510 February 8, 2007 Hermann et al.
20070051904 March 8, 2007 Kaiser et al.
20070061937 March 22, 2007 Curle
20070092812 April 26, 2007 Caporaso et al.
20070145916 June 28, 2007 Caporaso et al.
20070171015 July 26, 2007 Antaya
20070181519 August 9, 2007 Khoshnevis
20070284548 December 13, 2007 Kaiser et al.
20080093567 April 24, 2008 Gall
20080218102 September 11, 2008 Sliski
20090096179 April 16, 2009 Stark et al.
20090140671 June 4, 2009 O'Neal, III et al.
20090140672 June 4, 2009 Gall et al.
20090200483 August 13, 2009 Gall et al.
20100045213 February 25, 2010 Sliski
20100230617 September 16, 2010 Gall
20100308235 December 9, 2010 Sliski
20110299919 December 8, 2011 Stark
20130053616 February 28, 2013 Gall
20130127375 May 23, 2013 Sliski
20130131424 May 23, 2013 Sliski
20130237425 September 12, 2013 Leigh et al.
20140097920 April 10, 2014 Goldie et al.
Foreign Patent Documents
2629333 May 2007 CA
1537657 October 2004 CN
1816243 August 2006 CN
101932361 December 2010 CN
101933405 December 2010 CN
101933405 December 2010 CN
101933406 December 2010 CN
101061759 May 2011 CN
ZL200880125918.1 July 2013 CN
103347363 October 2013 CN
27 53 397 June 1978 DE
31 48 100 June 1983 DE
35 30 446 August 1984 DE
41 01 094 May 1992 DE
4411171 October 1995 DE
0194728 September 1986 EP
0194728 September 1986 EP
0 277 521 August 1988 EP
0 208 163 January 1989 EP
0 222 786 July 1990 EP
0 221 987 January 1991 EP
0499253 August 1992 EP
0499253 August 1992 EP
0 306 966 April 1995 EP
0 388 123 May 1995 EP
0 465 597 May 1997 EP
0 864 337 September 1998 EP
0 776 595 December 1998 EP
1 069 809 January 2001 EP
1 153 398 April 2001 EP
1 294 445 March 2003 EP
1 348 465 October 2003 EP
1 358 908 November 2003 EP
1 371 390 December 2003 EP
1 402 923 March 2004 EP
0 911 064 June 2004 EP
1 430 932 June 2004 EP
1 454 654 September 2004 EP
1 454 655 September 2004 EP
1 454 656 September 2004 EP
1 454 657 September 2004 EP
1 477 206 November 2004 EP
1 605 742 December 2005 EP
1 738 798 January 2007 EP
1826778 August 2007 EP
1826778 August 2007 EP
1949404 July 2008 EP
2183753 July 2008 EP
2394498 February 2010 EP
2227295 September 2010 EP
2232961 September 2010 EP
2232962 September 2010 EP
2227295 May 2011 EP
2363170 September 2011 EP
2363171 September 2011 EP
1672670 February 2014 EP
2 560 421 August 1985 FR
2911843 August 2008 FR
2911843 August 2008 FR
957342 May 1964 GB
2015821 September 1979 GB
2 361 523 October 2001 GB
43-23267 October 1968 JP
47-0028762 August 1972 JP
S47-028762 August 1972 JP
48-108098 December 1973 JP
U48-108098 December 1973 JP
61-80800 April 1986 JP
61-225798 October 1986 JP
A61-225798 October 1986 JP
62-150804 July 1987 JP
62-186500 August 1987 JP
63-149344 June 1988 JP
63-218200 September 1988 JP
63-226899 September 1988 JP
1-276797 November 1989 JP
4-94198 March 1992 JP
04-128717 April 1992 JP
04-129768 April 1992 JP
04-273409 September 1992 JP
04-337300 November 1992 JP
05-341352 December 1993 JP
06-233831 August 1994 JP
06233831 August 1994 JP
06233831 August 1994 JP
06-036893 October 1994 JP
07-260939 October 1995 JP
2007-260939 October 1995 JP
07260939 October 1995 JP
08-173890 July 1996 JP
08-264298 October 1996 JP
09-162585 June 1997 JP
10-071213 March 1998 JP
11-47287 February 1999 JP
11-102800 April 1999 JP
11-243295 September 1999 JP
2000-243309 September 2000 JP
2000-294399 October 2000 JP
2001-6900 January 2001 JP
2001-129103 May 2001 JP
2002-164686 June 2002 JP
2003-504628 February 2003 JP
A2003-504628 February 2003 JP
2004-031115 January 2004 JP
2004-031115 January 2004 JP
2006-032282 February 2006 JP
2009-515671 April 2009 JP
S48-108098 March 2010 JP
2010-536130 November 2010 JP
2011-505191 February 2011 JP
2011-505670 February 2011 JP
2011-507151 March 2011 JP
5046928 July 2012 JP
5607536 September 2014 JP
5607536 October 2014 JP
300137 November 1969 SU
569 635 August 1977 SU
200930160 July 2009 TW
200934682 August 2009 TW
200939908 September 2009 TW
200940120 October 2009 TW
WO 86/07229 December 1986 WO
WO90/12413 October 1990 WO
WO 92/03028 February 1992 WO
WO 93/02536 February 1993 WO
WO 98/17342 April 1998 WO
WO99/39385 August 1999 WO
WO 00/40064 July 2000 WO
WO 00/49624 August 2000 WO
WO 01/05199 January 2001 WO
WO 01/26569 April 2001 WO
WO 02/07817 January 2002 WO
WO 03/039212 May 2003 WO
WO 03/092812 November 2003 WO
WO 2004/026401 April 2004 WO
WO 2004/101070 November 2004 WO
WO 2006/012467 February 2006 WO
2007/061937 May 2007 WO
WO2007/061937 May 2007 WO
WO2007/084701 July 2007 WO
WO2007/130164 November 2007 WO
WO2007/145906 December 2007 WO
WO-2007145906 December 2007 WO
WO2008/030911 March 2008 WO
WO 2008/081480 October 2008 WO
WO 2009/048745 April 2009 WO
WO2009-070173 June 2009 WO
WO2009/070588 June 2009 WO
WO2009-070588 June 2009 WO
WO2009-073480 June 2009 WO
WO 2009/048745 November 2009 WO
Other references
  • Angert, N (GSI, Darmstadt), CAS—CERN Accelerator School : 5th General Accelerator Physics Course, Jyväskylä, Finland, Sep. 7-18, 1992, pp. 619-642 (CERN-1994-001).
  • First Office Action (Chinese Translation) for CN 201310240538,5, 4 pages dated May 20, 2015.
  • First Office Action (English Translation) for CN 201310240538.5, 6 pages dated May 20, 2015.
  • Second Office Action (Chinese Translation) for CN 201310240538.5, 5 pages dated Dec. 4, 2015.
  • Examination Report for CA 2706,952, 5 pages dated Mar. 23, 2015.
  • Communication pursuant to Article 71(3) EPC FOR EP 08855024.9, 35 pages dated Sep. 19, 2016.
  • Communication pursuant to Article 94(3) EPC for EP 08855024.9, 6 pages dated Jul. 9, 2015.
  • Communication pursuant to Article 94(3) EPC for EP 08855024.9, 7 pages dated Apr. 6, 2016.
  • U.S. Provisional application No. 60/850,565, filed on Oct. 10, 2006, including copy of application as filed, transaction history from Pair (PTO website).
  • U.S. Provisional application No. 60/991,454, filed on Nov. 30, 2007, including copy of application as filed, transaction history from Pair (PTO website).
  • Written Opinion for PCT/US2007/001628, dated Feb. 18, 2008 (11 pages).
  • Cosgrove et al., “Microdosimetric Studies on the Orsay Proton Synchrocyclotron at 73 and 200 MeV,” Radiation Protection Dosimetry, 1997, 70(1-4):493-496.
  • Coupland, High-field (5 T) pulsed superconducting dipole magnet, Proceedings of the Institution of Electrical Engineers, Jul. 1974, 121(7):771-778.
  • Coutrakon et al. Proton Synchrotrons for Cancer Therapy, Application of Accelerators in Research and Industry- Sixteenth International Conf., American Institute of Physics, Nov. 1-5, 2000, vol. 576, pp. 861-864.
  • Coutrakon et al., a prototype beam delivery system for the proton medical accelerator at Loma Linda, Medical Physics, Nov/Dec 1991, 18(6):1093-1099.
  • Cuttone, Applications of a Particle Accelerators in Medical Physics, Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali del Sud, V.S. Sofia, 44 Cantania, Italy, Jan. 2010, 17 pages.
  • Cuttone, G., “Applications of a Particle Accelerators in Medical Physics,” Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali del Sud, V.S. Sofia, 44 Cantania, Italy (17 pp.). No. date.
  • Dahl P, Superconducting Magnet System, American Institute of Physics, Aip Conference Proceedings, 1987-1988, 2: 1329-1376.
  • Dialog Search, Jan. 31, 2005, 17 pages.
  • Dugan et al., Tevatron Status IEEE, Particle Accelerator Conference, Accelerator Science & Technology, 1989, pp. 426-430.
  • Eickhoff et al., the Proposed Accelerator Facility for Light Ion Cancer Therapy in Heidelberg, Proceedings of the 1999 Particle Accelerator Conference, New York, 1999, pp. 2513-2515.
  • Enchevich et al., Minimizing Phase Losses in the 680 MeV Synchrocyclotron by Correcting the Accelerating Voltage Amplitude, Atomnava Energiva, 1969, 26:(3):315-316.
  • Endo et al., Compact Proton and Carbon Ion Synchrotrons for Radiation Therapy, Proceedings of EPAC 2002, Paris France, 2002, pp. 2733-2735.
  • European Communication from corresponding European application No. 11165422.4 dated Sep. 2, 2011 (5 pages).
  • European Communication from corresponding European application No. 11165423.2 dated Sep. 2, 2011 (5 pages).
  • European Communication from European application No. 06838033.6 dated Apr. 20, 2010 (7 pages).
  • European Communication from European application No. 07868958.5, dated Nov. 26, 2010 (50 pages).
  • European Patent Office communication from European application No. 08855024.9, dated Jul. 30, 2010 (2 pages).
  • European Patent Office communication from European application No. 07868958.5, dated Jul. 16, 2010 (2 pages).
  • European Patent Office communication from European application No. 08856764.9, dated Jul. 30, 2010 (2 pages).
  • European Search Report from corresponding European application No. 11165422.4 dated Aug. 8, 2011 (118 pages).
  • European Search Report from corresponding European application No. 11165423.2 dated Aug. 8, 2011 (118 pages).
  • File History of U.S. Pat. No. 8,581,523 (downloaded from Pair Mar. 21, 2017).
  • File History of U.S. Pat. No. 8,970,137 (downloaded from Pair Mar. 21, 2017).
  • Flanz et al., “Operation of a Cyclotron Based Proton Therapy Facility”, Massachusetts General Hospital, Boston, Ma 02114, pp. 1-4, retrieved from Internet in 2009.
  • Flanz et al., Large Medical Gantries, Particle Accelerator Conference, Massachusetts General Hospital, 1995, pp. 1-5.
  • Flanz et al., the Northeast Proton Therapy Center at Massachusetts General Hospital, Fifth Workshop on Heavy Charge Particles in Biology and Medicine, Gsi, Darmstadt, Aug. 1995, 11 pp.
  • Flanz et al., Treating Patients with the NPTC Accelerator Based Proton Treatment Facility, Proceedings of the 2003 Particle Accelerator Conference, 2003, pp. 690-693.
  • Flanz, et al., “Scanning Beam Technologies”, PTCOG 2008, 28 pages.
  • Flood and Frazier, The Wide-Band Driven RF System for the Berkeley 88-Inch Cyclotron, American Institute of Physics, Conference Proceedings., No. 9, 1972, 459-466.
  • Foster and Kashikhin, Superconducting Superferric Dipole Magent with Cold Iron Core for the VLHC, IEEE Transactions on Applied Superconductivity, Mar. 2002, 12(1):111-115.
  • Friesel et al., Design and Construction Progress on the IUCF Midwest Proton Radiation Institute, Proceedings of EPAC 2002, 2002, pp. 2736-2738.
  • Fukumoto et al., A Proton Therapy Facility Plan Cyclotrons and their Applications, Proceedings of the 13th International Conference, Vancouver, Canada, Jul. 6-10, 1992, pp. 258-261.
  • Fukumoto, Cyclotron Versus Synchrotron for Proton Beam Therapy, KEK Prepr., No. 95-122, Oct. 1995, pp. 533-536.
  • Gordon, et. al., Design Study for a Compact 200 MeV Cyclotron, AIP Conference Proceedings Sixth International Cyclotron Conference, No. 9, pp. 78-86 (1972).
  • Gordon, M. M., Extraction Studies for a 250 MeV Superconducting Synchrocyclotron, Proceedings of the 1987 IEEE Particle Accelerator Conference: Accelerator Engineering and Technology, pp. 1255-1257 (1987).
  • Goto et al., Progress on the Sector Magnets for the Riken SRC, American Institute of Physics, 714 CP600, Cyclotrons and Their Applications 2001, Sixteenth International Conference, 2001, pp. 319-323.
  • Graffman et al., Acta Radial. Therapy Phys. Biol. 1970, 9, 1 (1970).
  • Graffman et al., Design Studies for a 200 MeV Proton Clinic for Radiotherapy, AIP Conference Proceedings: Cyclotrons—1972, 1972, No. 9, pp. 603-615.
  • Graffman, et. al. Proton radiotherapy with the Uppsala cyclotron. Experience and plans Strahlentherapie, 1985, 161(12):764-770.
  • Hede, Research Groups Promoting Proton Therapy Lite, Journal of the National Cancer Institute, Dec. 6, 2006, 98(23):1682-1684.
  • Heinz, Superconducting Pulsed Magnetic Systems for High-Energy Synchrotrons, Proceedings of the Fourth International Cryogenic Engineering Conference, May 24-26, 1972, pp. 55-63.
  • Hentschel et al., Plans for the German National Neutron Therapy Centre with a Hospital-Based 70 MeV Proton Cyclotron at University Hospital Essen/Germany, Cyclotrons and their Applications, Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, Caen, Franco, Jun. 14-19, 1998, pp. 21-23.
  • Hepburn et al., Superconducting Cyclotron Neutron Source for Therapy, International Journal of Radiation Oncology Biology Physics, vol. 3 complete, 1977, pp. 387-391.
  • Hirabayashi, Development of Superconducting Magnets for Beam Lines and Accelerator at KEK, IEEE Transaction on Magnetics, Jan. 1981, Mag-17(1 ):728-731.
  • International Search Report and Written Opinion for PCT application No. PCT/US2008/084695 dated Jan. 26, 2009 (15 pages).
  • International Search Report and Written Opinion from corresponding PCT application No. PCT/US2008/084695 dated Jan. 26, 2009 (13 pages).
  • Ishibashi and Mcinturff, Stress Analysis of Superconducting 1 OT Magnets for Synchrotron, Proceedings of the Ninth International Cryogenic Engineering Conference, May 11-14, 1982, pp. 513-516.
  • Ishibashi and Mcinturff, Winding Design Study of Superconducting 10 T Dipoles for a Synchrotron, IEEE Transactions on Magnetics, May 1983, Mag-19(3):1364-1367.
  • Jahnke et al., First Superconducting Prototype Magnets for a Compact Synchrotron Radiation Source in Operation, IEEE Transactions on Magnetics, Mar. 1988, 24(2):1230-1232.
  • Japanese Office action with English translation from corresponding Japanese application No. 2010- 536130 dated Jun. 4, 2013 (8 pages).
  • Japanese Office Action with English translation from corresponding Japanese application No. 2010- 536130 dated Feb. 10, 2014 (9 pages).
  • Jones and Dershem, Synchrotron Radiation from Proton in a 20 TEV, 10 TESLA Superconducting Super Collider Proceedings of the 12th International Conference on High-Energy Accelerator, Aug. 11-16, 1983, pp. 138-140.
  • Jones and Mills, The South African National Accelerator Centre: Particle Therapy and Isotope Production Programmes, Radiation Physics and Chemistry, Apr.- Jun. 1998, 51 ( 4-6):571578.
  • Jones et al., Status Report of the NAC Particle Therapy Programme, Stralentherapie and Onkologie, vol. 175, Suppl. II, Jun. 1999, pp. 30-32.
  • Jones, Present Status and Future Trends of Heavy Particle Radiotherapy, Cyclotrons and their Applications 1998, Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, Jun. 14-19, 1998, pp. 13-20.
  • Jones, Progress with the 200 MeV Cyclotron Facility at the National Accelerator Centre, Commission of the European Communities Radiation Protection Proceedings, Fifth Symposium on Neutron Dosimetry, Sep. 17-21, 1984, vol. II, pp. 989-998.
  • Jongen et al., Development of a Low-cost Compact Cyclotron System for Proton Therapy, National Institute of Radiol. Sci,1991, No. 81, DD. 189-200.
  • Jongen et al., Progress report on the IBA-SHI small cyclotron for cancer therapy Nuclear Instruments and Methods in Physics Research, Section B, vol. 79, issue 1-4, 1993, pp. 885-889.
  • Jongen et al., the proton therapy system for MGH's NPTC: equipment description and progress report, Bulletin du Cancer/Radiotherapie, Proceedings of the meeting of the European Heavy Particle Therapy Group, 1996, 83(Suppl. 1):219-222.
  • Jongen et al., The proton therapy system for the NPTC: Equipment Description and progress report, Nuclear Instruments and methods in physics research, 1996, Section B, 113(1 ): 522-525.
  • Kanai et al., Three-dimensional Beam Scanning for Proton Therapy, Nuclear Instruments and Methods in Physic Research, Sep. 1, 1983, The Netherlands, 214(23):491-496.
  • Karlin et al., Medical Radiology (Moscow), 1983, 28, 13.
  • Karlin et al., The State and Prospects in the Development of the Medical Proton Tract on the Synchrocyclotron in Gatchina, Med. Radial., Moscow, 28(3):28-32 (Mar. 1983)(German with English Abstract on end of page 32).
  • Kats and Druzhinin, Comparison of Methods for Irradiation Prone Patients, Atomic Energy, Feb. 2003, 94(2): 120-123.
  • Kats and Onosovskii, A Planar Magnetooptical System for the Irradiation of a Lying Patient with a Proton Beam from Various Directions, Instruments and Experimental Techniques, 1996, 39(1):127-131.
  • Kats and Onosovskii, A Simple, Compact, Flat System for the Irradiation of a Lying Patient with a Proton Beam from Different Directions, Instruments and Experimental Techniques, 1996, 39(1):132-134.
  • Khoroshkov et al., Moscow Hospital-Based Proton Therapy Facility Design, Am. Journal Clinical Oncology: CCT, Apr. 1994, 17(2):109-114.
  • Kim and Blosser, Optimized Magnet for a 250 MeV Proton Radiotherapy Cyclotron, Cyclotrons and Their Applications 2001, May 2001, Sixteenth International Conference, pp. 345-347.
  • Kim and Yun, A Light-Ion Superconducting Cyclotron System for Multi-Disciplinary Users, Journal of the Korean Physical Society, Sep. 2003, 43(3):325-331.
  • Kim et al., Construction of 8T Magnet Test Stand for Cyclotron Studies, IEEE Transactions on Applied Superconductivity, Mar. 1993, 3(1):266-268.
  • Kim et al., Design Study of a Superconducting Cyclotron for Heavy Ion Therapy, Cyclotrons and Their Applications 2001, Sixteenth International Conference, May 13-17 2001, pp. 324-326.
  • Kim et al., Trim Coil System for the Riken Cyclotron Ring Cyclotron, Proceedings of the 1997 Particle Accelerator Conference, IEEE, Dec. 1981, vol. 3, pp. 214-235 or 3422-3424, 1998.
  • Kim, An Eight Tesla Superconducting Magnet for Cyclotron Studies, Ph.D. Dissertation, Michigan State University, Department of Physics and Astronomy, 1994, 13 8 pages.
  • Kishida and Yano, Beam Transport System for the RIKEN SSC (II), Scientific Papers of the Institute of Physical and Chemical Research, Dec. 1981, 75(4):214-235.
  • Kleeven, W., Injection and extraction for cyclotrons, Proceedings of the Specialised CERN Accelerator School on Small Accelerators, pp. 271-286 (2006).
  • Koehler et al., Range Modulators for Protons and Heavy Ions, Nuclear Instruments and Methods, 1975, vol. 131, pp. 437-440.
  • Koehler, A.M., et al., Range Modulators for Protons and Heavy Ions, Nuclear Instruments and Methods, vol. 131, DD. 437-440 (1975).
  • Koto and Tsujii, Future of Particle Thera12y, Ja12anese Journal of Cancer Clinics, 2001, 47(1):95-98 [Lang.: Japanese], English abstract (htt12://sciencelinks.j12/jeast/article/200206/000020020601A05 I 1453 .nhn).
  • Kraft et al., Hadrontherapy in Oncology, U. Amaldi and Larrsson, editors Elsevier Science, 1994, 161 pages.
  • Krevet et al., Design of a Strongly Curved Superconducting Bending Magnet for a Compact Synchrotron Light Source, Advances in Cryogenic Engineering, 1988, vol. 33, pp. 25-32.
  • Krevet, et al, “Design of a Strongly Curved Superconducting Bending Magnet for a Compact Synchrotron Light Source”, Advances in Cryogenic Engineering, vol. 33, pp. 25-32 (Dec. 3, 1988).
  • Laisne et al., “The Orsay 200 MeV Synchrocyclotron,” IEEE Transactions on Nuclear Science, Apr. 1979, NS-26(2):1919-1922.
  • Larsson et al., Nature, 1958, 182:1222.
  • Larsson, Biomedical Program for the Converted 200-MeV Synchrocyclotron at the Gustaf Werner Institute, Radiation Research, 1985, 104:S310-S318.
  • Lawrence et al., Heavy particles in acromegaly and Cushing's Disease, in Endocrine and Norendocrine Hormone Producing Tumors (Year Book Medical Chicago, 1973, pp. 29-61.
  • Lawrence et al., Successful Treatment of Acromegaly: Metabolic and Clinical Studies in 145 Patients, the Journal of Clinical Endrocrinology and Metabolism, Aug. 1970, 31(2), 21 pages.
  • Lawrence et al., Treatment of Pituitary Tumors, (Excerpta medica, Amsterdam/American Elsevier, New York, 1973, pp. 253-262.
  • Lawrence, Cancer, 1957, 10:795.
  • Lecroy et al., Viewing Probe for High Voltage Pulses, Review of Scientific Instruments USA, Dec. 1960, 31(12):1354.
  • Lin et al., “Principles and 10 Year Experience of the Beam Monitor System at the PSI Scanned Proton Therapy Facility”, Center for Proton Radiation Therapy, Paul Scherrer Institute, CH-5232, Villigen PSI, Switzerland, 2007, 21 pages.
  • Linfoot et al., Acromegaly, in Hormonal Proteins and Peptides, edited by C.H. Li, 1975, pp. 191-246.
  • Literature Keyword Search, Jan. 24, 2005, 98 pages.
  • Literature Search, Jan. 26, 2005, 37 pages.
  • Mandrillon, High Energy Medical Accelerators, EPAC 90, 2nd European Particle Accelerator Conference, Jun. 12-16, 1990, 2:54-58.
  • Marchand et al., “1EA Proton Pencil Beam Scanning: an Innovative Solution for Cancer Treatment,” Proceedings of EPAC 2000, Vienna, Austria, 3 pages.
  • Marti et al., High Intensity Operation of a Superconducting Cyclotron, Proceedings of the 4th International Conference, Cyclotrons and Their Applications, Oct. 1995, pp. 45-48 (Oct. 1995).
  • Martin, Operational Experience with Superconducting Synchrotron Magnets Proceedings of the 1987 IEEE Particle Accelerator Conference, Mar. 16-19, 1987, vol. 3 of 3: 1379-1382.
  • Meote et al., ETOILE Hadrontherapy Project, Review of Design Studies Proceedings of EPAC 2002, 2002, pp. 2745-2747.
  • Miyamoto et al., Development of the Proton Therapy System, The Hitachi Hyoron, 79(10):775775 779 (1997) [Lang: Japanese], English abstract (http://www.hitachi.com/rev/1998/revfeb98/rev4 706.htm).
  • Montelius et al., The Narrow Proton Beam Therapy Unit at the Svedberg Laboratory in Uppsala, ACTA Oncologica, 1991, 30:739-745.
  • Moser et al., Nonlinear Beam Optics with Real Fields in Compact Storage Rings, Nuclear Instruments & Methods in Physics Research/Section B, B30, Feb. 1988, No. 1, pp. 105-109.
  • Moyers et al., “A Continuously Variable Thickness Scatterer for Proton Beams Using Self-compensating Dual Linear Wedges” Lorna Linda University Medical Center, Dept. Of Radiation Medicine, Lorna Linda, Ca, Nov. 2, 1992, 21 pp.
  • National Cancer Institute Funding (Senate-Se12tember 21,1992} (w>lvw.tbomas.loc.gov/cgibin/querv/z?r102:S21SE2-712 12 na2es).
  • Nicholson, Applications of Proton Beam Therapy, Journal of the American Society of Radiologic Technologists, May/Jun. 1996, 67(5): 439-441.
  • Nolen et al., the Integrated Cryogenic—Superconducting Beam Transport System Planned for MSU, Proceedings of the J21h International Conference on High-Energy Accelerators, Aug. 1983, pp. 549-551.
  • Non Final Office Action from U.S. Appl. No. 11/948,359 dated Aug. 20, 2010 (12 pages).
  • Non Final Office Action from U.S. Appl. No. 12/275,103 dated Feb. 1, 2011 (6 pages).
  • Non Final Office Action from U.S. Appl. No. 12/618,297 dated May 13, 2011 (44 pages).
  • Norimine et al., a Design of a Rotating Gantry with Easy Steering for Proton Therapy, Proceedings of EPAC 2002, 2002, pp. 2751-2753.
  • Office action from U.S. Appl. No. 11/948,359, dated Aug. 20, 2010 (12 pages).
  • Office action with English translation dated Feb. 10, 2014 from corresponding Japanese application No. 2010-536130 ( 5 pages).
  • Okumura et al., Overview and Future Prospect of Proton Radiotherapy, Japanese Journal of Cancer Clinics, 1997, 43(2):209-214 [Lang: Japanese].
  • Okumura et al., Proton Radiotherapy Japanese Journal of Cancer and Chemotherapy, 1993, 10. 20(14):2149-2155[Lang.: Japanese].
  • Outstanding from Search Reports, Accelerator of Polarized Portons at Fermilab, 2005, 20 pages.
  • Palmer and Tollestrup, Superconducting Magnet Technology for Accelerators, Annual Review of Nuclear and Particle Science, 1984, vol. 34, pp. 247-284.
  • Pardo, J. et al., Simulation of the performance of the Cnao facility's Beam Delivery System, PTCOG 46, Zibo, China, 17 pages (2007).
  • Patent Assignee and Keyword Searches for Synchrocyclotron, Jan. 25, 2005, 78 pages.
  • Pavlovic, Beam-optics study of the gantry beam delivery system for light-ion cancer therapy, Nuclear Instruments and Methods in Physics Research, Section A, Nov. 1997, 399(2):439-454(16).
  • Pedroni and Enge, Beam optics design of compact gantry for proton therapy Medical & Biological Engineering & Computing, May 1995, 33(3):271-277.
  • Pedroni and Jermann, Sgsmp: Bulletin Mar. 2002 Proscan Project, Progress Report on the Proscan.
  • Pedroni et al., A Novel Gantry for Proton Therapy at the Paul Scherrer Institute, Cycloctrons and Their Applications 2001: Sixteenth International Conference. Aip Conference Proceedings, 2001, 600:13-17.
  • Pedroni et al., the 200-MeV proton therapy project at the Paul Scherrer Institute: Conceptual design and practical realization, Medical Physics, Jan. 1995, 22(1 ):37-53.
  • Pedroni, “Status of Proton Therapy: results and future trends,” Paul Scherrer Institute, Division of Radiation Medicine, 1994, 5 pages.
  • Pedroni, Accelerators for Charged Particle Therapy: Performance Criteria from the User Point of View, Cyclotrons and their Applications, Proceedings of the 13th International Conference, Jul. 6-10, 1992, pp. 226-233.
  • Pedroni, Latest Developments in Proton Therapy Proceedings of Epac 2000, pp. 240-244, 2000.
  • Potts et al., MPWP6-Therapy Iii: Treatment Aids and Techniques Medical Physics, Sep/Oct 1988, 15(5):798.
  • Pourrahimi et al., Powder Metallurgy Processed Nb3Sn(Ta) Wire for High Field NMR magnets, IEEE Transactions on Applied Superconductivity, Jun. 1995, 5(2):1603-1606.
  • Prieels et al., The IBA State-of-the-Art Proton Therapy System, Performances and Recent Results, Application of Accelerators in Research and industry—Sixteenth Int'l Conj, American Institute of Physics, Nov 1-5, 2000, 576:857-860.
  • Rabin et al., Compact Designs for Comprehensive Proton Beam Clinical Facilities, Nuclear Instruments & Methods in Physics Research, Apr. 1989, Section B, vol. 40-41, Part II, pp. 1335-1339.
  • Renner et al., “Preliminary Results of a Raster Scanning Beam Delivery System”, IEEE, 1989, 3 pages.
  • Research & Development Magazine, Proton Therapy Center Nearing Completion, Aug. 1999, 41(9):2 pages (www.rdmag.com).
  • Resmini Design Characteristics of the K=800 Superconducting Cyclotron at M.S.U., Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824, IEEE Transaction on Nuclear Science, vol. NS-26, No. 2, Apr. 1979, 8 pages.
  • Response to Non Final Office Action dated Feb. 1, 2011 in U.S. Appl. No. 12/275,103 filed May 2, 2011 (13 pages).
  • Response to Office Action dated Aug. 20, 2010 in U.S. Appl. No. 11/948,359 filed Feb. 22, 2011 (17 pages).
  • Response with English translation to Japanese Office action dated Feb. 10, 2014 from corresponding Japanese application No. 2010-536130, filed May 8, 2014 (15 pages).
  • Revised Patent Keyword Search, Jan. 25, 2005, 86 pages.
  • Rifuggiato et, al., Status Report of the LNS Superconducting Cyclotron Nukleonika, 2003, 48:SI31-SI34, Supplement 2.
  • Rode, Tevatron Cryogenic System, Proceedings of the 12th International Conference on Highenergy Accelerators, Fermilab, Aug. 11-16, 1983, pp. 529-535.
  • Salzburger et al., “Superconducting Synchrotron Magnets Supraleitende Synchrotronmagnete,” Siemens A.G., Erlangen (West Germany). Abteilung Technische Physik, Report No. BMFT-FB-T-75-25, Oct. 1975, p. 147, Journal Announcement: GRA17619; STAR1415,Subm-Sponsored by Bundesmin. Fuer Forsch. U. Technol. In German; English Summary.
  • Salzburger et al., Superconducting Synchrotron Magnets Supraleitende Synchrotronmagnete, NTiS, 155 pages (Oct. 1975).
  • Schillo et al,. Compact Superconducting 250 MeV Proton Cyclotron for the PSI Proscan Proton Therapy Project, Cyclotrons and Their Applications 2001, Sixteenth International Conference, 2001, pp. 37-39.
  • Schneider et al., Nevis Synchrocyclotron Conversion Program—RF System, IEEE Transactions on Nuclear Science USA, Jun. 1969, ns. 16(3): 430-433.
  • Schreuder et al., The Non-orthogonal Fixed Beam Arrangement for the Second Proton Therapy Facility at the National Accelerator Centre, Application of Accelerators in Research and Industry, American Institute of Physics, Proceedings of the Fifteenth International Conference, Nov 1998, Part Two, pp. 963-966.
  • Schreuder, Recent Developments in Superconducting Cyclotrons, Proceedings of the 1995 Particle Accelerator Conference, May 1-5, 1995, vol. 1, pp. 317-321.
  • Schubert and Blosser, Conceptual Design of a High Field Ultra-Compact Cyclotron for Nuclear Physics Research, Proceedings of the 1997 Particle Accelerator Conference, May 12-16, 1997, vol. 1, 3 pages 1060-1062.
  • Schubert, Extending the Feasibility Boundary of the Isochronous Cyclotron, Dissertation submitted to Michigan State University, 1997, Abstract http://adsabs.harvard.edu/abs/1998PhDT. . . 147S.
  • Shelaev et al., Design Features of a Model Superconducting Synchrotron of JINR, Proceedings of the 12th International Conference on High-energy Accelerators, Aug. 11-16, 1983, pp. 416-418.
  • Shintomi et. Al, Technology and Materials for the Superconducting Super Collider (SSC) Project, [Lang.: Japanese], The Iron and Steel Institute of Japan 00211575, 78(8): 1305-1313, 1992, http://ci.nii.ac.ip/naid/I I 0001493249/en/.
  • Sisterson, Clinical use of proton and ion beams from a world-wide perspective, Nuclear Instruments and Methods in Physics Research, Section B, 1989, 40-41:1350-1353.
  • Sisterson, World Wide Proton Therapy Experience in 1997, The American Institute of Physics, Applications of Accelerators in Research and Industry, Proceedings of the Fifteenth International Conference, Part Two, Nov 1998, pp. 959-962.
  • Slater et al., Developing a Clinical Proton Accelerator Facility: Consortium-Assisted Technology Transfer, Conference Record of the 1991 IEEE Particle Accelerator Conference: Accelerator Science and Technology, vol. I, May 6-9, 1991, pp. 532-536.
  • Slater et al., Development of a Hospital-Based Proton Beam Treatment Center, International Journal of Radiation Oncology J Biolog J Physics, Apr. 1988, 14(4):761-775.
  • Smith et al., the Northeast Proton Therapy Center at Massachusetts General Hospital Journal of Brachytherapy International, Jan. 1997, pp. 137-139.
  • Snyder and Marti, Central region design studies for a proposed 250 MeV proton cyclotron, Nuclear Instruments and Methods in Physics Research, Section A, 1995, vol. 355, pp. 618-623.
  • Soga, Progress of Particle Therapy in Japan, Application of Accelerators in Research and Industry, American Institute of Physics, Sixteenth International Conference, Nov. 2000, pp. 869-872.
  • Spiller et al., The GSI Synchrotron Facility Proposal for Acceleration of High Intensity Ion and Proton Beams Proceedings of the 2003 Particle Accelerator Conference, May 12-16, 2003, vol. 1, pp. 589-591.
  • Stanford et al., “Method of Temperature Control in Microwave Ferroelectric Measurements,” Sperry Microwave Electronics Company, Clearwater, Florida, Sep. 19, 1960, 1 page.
  • Superconducting Cyclotron Contract awarded by Paul Scherrer Institute (PSI), Villigen, Switzerland, http://www.accel.de/News/superconducting_ cyclotron_ contract.htm, Jan. 2009, 1 page.
  • Tadashi et al., “Large superconducting super collider (SSC) in the planning and materials technology,” 1992, 78(8):1305-1313, the Iron and Steel Institute of Japan 00211575.
  • Tadashi et al., Large superconducting super collider (SSC) in the planning and materials technology,78(8):1305-1313, The Iron and Steel Institute of Japan 00211575, Aug. 1992.
  • Takada, Conceptual Design of a Proton Rotating Gantry for Cancer Therapy, Japanese Journal of Medical Physics, 1995, 15(4):270-284.
  • Takayama et al., Compact Cyclotron for Proton Therapy, Proceedings of the 81 h Symposium on Accelerator Science and Technology, Japan, Nov. 25-27, 1991, pp. 380-382.
  • Teng, The Fermilab Tevatron, Coral Gables 1981, Proceedings, Gauge Theories, Massive Neutrinos, and Proton Decay, 1981, pp. 43-62.
  • The Davis 76-Inch Isochronous Cyclotron, Beam On: Crocker Nuclear Laboratory, University of California, 2009, 1 page.
  • The Journal of Practical Pharmacy,1995, 46(1):97-103 [Japanese].
  • The K100 Neutron-therapy Cyclotron, National Superconducting Cyclotron Laboratory at Michigan State University (NSCL ), retrieved from: http://www.nscl.msu.edu/tech/accelerators/kl00, Feb. 2005, 1 page.
  • The K250 Proton therapy Cyclotron, National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.edu/tech/accelerators/k.250.html, Feb. 2005, 2 pages.
  • The K250 Proton-therapy Cyclotron Photo Illustration, National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.edu/media/image/ experimental-equipment-technology /25 0 .html, Feb. 2005, 1 page.
  • Timmer, “The ACCEL Single Room Proton Therapy Facility” ACCEL Instruments GmbH, PTCOG 45, Oct. 2006, Houston, Texas, 18 pages.
  • Tobias et al., Cancer Research,1958, 18, 121 (1958).
  • Tom, The Use of Compact Cyclotrons for Producing Fast Neutrons for Therapy in a Rotatable Isocentric Gantry, IEEE Transaction on Nuclear Science, Apr. 1979, 26(2):2294-2298.
  • Toyoda, Proton Therapy System, Sumitomo Heavy Industries, Ltd., 2000, 5 pages.
  • Trinks et. al., The Tritron: A Superconducting Separated-Orbit Cyclotron, Nuclear Instruments and Methods in Physics Research, Section A, 1986, vol. 244, pp. 273-282.
  • Tsuji, The Future and Progress of Proton Beam Radiotherapy, Journal of Japanese Society for Therapeutic Radiology and Oncology, 1994, 6(2):63-76.
  • UC Davis School of Medicine, Unlikely Partners Tum Military Defense into Cancer Offense, Current Issue Summer 2008, Sacramento, California, pp. 1-2.
  • Umegaki et al., Development of an Advanced Proton Beam Therapy System for Cancer Treatment Hitachi Hyoron, 2003, 85(9):605-608 [Lang.: Japanese], English abstract, http://www.hitachi.com/ICSFiles/afieldfile/2004/06/01/r2003_ 04_ I 04.pdf or http://www.hitachi.com/rev/archive/2003/2005649_12606.html (full text) [Hitachi, 52( 4), Dec. 2003].
  • Umezawa et al., Beam Commissioning of the new Proton Therapy System for University of Tsukuba, Proceedings of the 2001 Particle Accelerator Conference, vol. 1, Jun. 18-22, 2001, pp. 648-650.
  • van Steenbergen, Superconducting Synchroton Development at Bnl, Proceedings of the 8th International Conference on High-Energy Accelerators CERN 1971, 1971, pp. 196-198.
  • van Steenbergen, the CMS, a Cold Magnet Synchrotron to Upgrade the Proton Energy Range of the BNL Facility, IEEE Transactions on Nuclear Science, Jun. 1971, 18(3):694-698.
  • Vandeplassche et al., 235 MeV Cyclotron for Mgh's Northeast Proton Therapy Center (NPTC): Present Status, EPAC 96, Fifth European Partical Accelerator Conference, vol. 3, Jun. 10-14, 1996, pp. 2650-2652.
  • Vorobiev et al., Concepts of a Compact Achromatic Proton Gantry with a Wide Scanning Field, Nuclear Instruments and Methods in Physics Research, Section A., 1998, 406(2):307-310.
  • Vrenken et al., A Design of a Compact Gantry for Proton Therapy with 2D-Scanning, Nuclear Instruments and Methods in Physics Research, Section A, 1999, 426(2):618-624.
  • Welton, R. F., RF-Plasma Coupling Schemes for the SNS Ion Source, AIP Conference Proceedings, vol. 694, Jan. 1, 2003 (Jan. 1, 2003), pp. 431-438, XP055119965.
  • Wikipedia, Cyclotron http://en.wiki11edia.org/wiki/Cyclotron (originally visited Oct. 6, 2005, revisited Jan. 28, 2009), 7 pages.
  • Wikipedia, Synchrotron http://en.wiki1ledia.org/wiki/Synchrotron (originally visited Oct. 6, 2005, revisited Jan. 28, 2009), 7 pages.
  • Wu, Conceptual Design and Orbit Dynamics in a 250 MeV Superconducting Synchrocyclotron, Ph.D. Dissertation, Michigan State University, Department of Physics and Astronomy, 1990, 172 pp.
  • Yamaya a, T., et al.: A Small Cold Cathode Heavy Ion Source for a Compact Cyclotron, Nuclear Instruments and Methods in Physics Research, vol. 226, 1 Jan. 1984 (1984-0101), pp. 219-222, XP055119506.
  • York et al., Present Status and Future Possibilities at NSCL-MSU, EP AC 94, Fourth European Particle Accelerator Conference, pp. 554-556, Jun. 1994.
  • York et al., the NSCL Coupled Cyclotron Project—Overview and Status, Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, Jun. 1998, pp. 687-691.
  • Yudelev et al., Hospital Based Superconducting Cyclotron for Neutron Therapy: Medical Physics Perspective, Cyclotrons and their applications 2001, 16th International Conference. American Institute of Physics Conference Proceedings, vol. 600, May 13-17, 2001, pp. 4043.
  • Zherbin et al., Proton Beam Therapy at the Leningrad Synchrocyclotron (Clinicomethodological Aspects and Therapeutic Results), Aug. 1987, 32(8):17-22, (German with English abstract on pp. 21-22).
  • Livingston, M. S., et. al. “A Capillary Ion Source for the Cyclotron” Review Science Instruments, vol. 10:63, pp. 63-67, (Feb. 1939).
  • English Translation of Notification of Reasons for Rejection in counterpart Japanese Application No. 2010-536130 dated Jun. 4, 2013.
  • Response to Office Action with English translation issued in corresponding Japanese Application No. 2010-536130, filed on Nov. 26, 2013 (24 pages).
  • Office action with English translation issued Feb. 10, 2014 from corresponding Japanese application No. 2010-536130 (5 pages).
  • Office action and response history of U.S. Appl. No. 11/601,056 to Mar. 24, 2009.
  • U.S. Appl. No. 60/738,404, filed Nov. 18, 2005.
  • U.S. Appl. No. 11/948,359, filed Nov. 30, 2007.
  • PCT application No. PCT/US2006/44853, filed on Nov. 17, 2006, with Publication No. WO/2007/061937.
  • U.S. Appl. No. 10/949,734, filed Sep. 24, 2004, Patent No. 7,208,748, issued on Apr. 24, 2007.
  • U.S. Appl. No. 11/724,055, filed Mar. 14, 2007.
  • U.S. Appl. No. 11/371,622, filed Mar. 9, 2006.
  • U.S. Appl. No. 60/590,088, filed Jul. 21, 2004.
  • U.S. Appl. No. 11/187,633, filed Jul. 21, 2005.
  • PCT application No. PCT/US2005/25942 filed on Jul. 21, 2005, with Publication No. WO/2006/012452.
  • U.S. Appl. No. 11/463,403, filed Aug. 9, 20006.
  • U.S. Appl. No. 11/517,490, filed Sep. 7, 2006.
  • U.S. Appl. No. 11/624,769, filed Jan. 19, 2007.
  • PCT application No. PCT/US2007/01506 filed on Jan. 19, 2007, with Publication No. WO/2007/084701.
  • PCT application No. PCT/US2007/01628 filed on Jan. 19, 2007, with Publication No. WO/2007/130164.
  • PCT application No. PCT/US2007/77693 filed on Sep. 6, 2007with Publication No. WO/2007/77693.
  • U.S. Appl. No. 11/870,961, filed Oct. 11, 2007.
  • PCT application No. PCT/US2008/077513, filed on Sep. 24, 2008.
  • PCT application No. PCT/US2008/084695 filed on Nov. 25, 2008.
  • PCT application No. PCT/US2008/084699 filed on Nov. 25, 2008.
  • U.S. Appl. No. 60/991,454, filed Nov. 30, 2007.
  • U.S. Appl. No. 12/275,103, filed Nov. 20, 2008.
  • PCT application No. PCT/US2007/086109 filed on Nov. 30, 2007.
  • U.S. Appl. No. 60/850,565, filed Oct. 10, 2006.
  • PCT International Search report and Written Opinion of PCT application No. PCT/US2006/044853, mailed Oct. 5, 2007 (12 pages).
  • PCT International Preliminary Report on Patentability of corresponding PCT application No. PCT/US2006/044853, mailed May 29, 2008 (8 pages).
  • International Search Report dated Aug. 26, 2008 in PCT application No. PCT/US2007/086109 (6 pages).
  • Written Opinion dated Aug. 26, 2008 in PCT application No. PCT/US2007/086109 (6 pages).
  • International Search Report and Written Opinion for PCT application No. PCT/US2008/084699 mailed Feb. 4, 2009 (11 pages).
  • International Search Report and Written Opinion for PCT application No. PCT/US2007/001506 mailed Jul. 5, 2007, Publication No. W02007/084701, Published Jul. 26, 2007 (14 pages).
  • International Preliminary Report on Patentability for PCT application No. PCT/US2007/001506 mailed Jul. 5, 2007 (15 pages).
  • International Search Report for PCT/US2007/001628 mailed Feb. 18, 2008 (4 pages).
  • Written Opinion for PCT/US2007/001628, mailed Feb. 18, 2008 (11 pages).
  • International Preliminary Report on Patentability for PCT/US2007/001628, mailed Apr. 22, 2008 (15 pages).
  • Abrosimov, N.K., et al. Proc. Academy Science, USSR 5, 84 (1985).
  • Abrosimov, N.K., et al, “1000MeV Proton Beam Therapy facility at Petersburg Nuclear Physics Institute Synchrocyclotron”, Medical Radiology (Moscow) 32, 10 (1987) revised in Journal of Physics, Conference Series 41, pp. 424-432, Institute of Physics Publishing Limited, 2006.
  • Adachi, T., et. al. “A 150MeV FFAG Synchrotron with “Return-Yoke Free” Magent” Proceedings of the 2001 Particle Accelerator Conference, Chicago (2001).
  • Ageyev, A. I., et. al. “The IHEP Accelerating and Storage Complex (UNK) Status Report” 11th International Conference on High-Energy Accelerators, pp. 60-70 (Jul. 7-11, 1980).
  • Agosteo, S., et. al. “Maze Design of a gantry room for proton therapy” Nuclear Instruments & Methods in Physics Research, Section A, 382, pp. 573-582 (1996).
  • Allardyce, B. W., et al., “Performance and Prospects of the Reconstructed CERN 600 MeV Synchrocyclotron” IEEE Transactions on Nuclear Science USA ns-24:(3), pp. 1631-1633 (Jun. 1977).
  • Alexeev, V. P., et. al. “R4 Design of Superconducting Magents for Proton Synchrotrons” Proceedings of the Fifth International Cryogenic Engineering Conference, pp. 531-533 (1974).
  • Amaldi, U. “Overview of the world landscape of Hadrontherapy and the projects of the TERA foundation” Physica Medica, An International journal Devoted to the Applications of Physics to Medicine and Biology, vol. XIV, Supplement 1 (Jul. 1998), 6th Workshop on Heavy Charged Particles in Biology and Medicine, Instituto Scientific Europeo (ISE), Baveno, pp. 76-85 (Sep. 29-Oct. 1, 1997).
  • Amaldi, U., et. al. “The Italian project for a hadrontherapy centre” Nuclear Instruments and Methods in Physics Research A, 360, pp. 297-301 (1995).
  • “An Accelerated Collaboration Meets with Beaming Success”, Lawrence Livermore National Laboratory, Apr. 12, 2006, S&TR,,Livermore, California, pp. 1-3. http: //www.llnl.gov/str/April06/Caporaso.html.
  • Anferov, V., et. al. “The Indiana University Midwest Proton Radiation Institute” Proceedings of the 2001 Particle Accelerator Conference, Chicago, pp. 645-647 (2001).
  • Anferov, V., et. al. “Status of the Midwest Proton Radiotherapy Institute”, Proceedings of the 2003 Particle Accelerator Conference, pp. 699-701 (2003).
  • Appun, J. “Various problems of magnet fabrication for high-energy accelerators” Journal for All Engineers Interested in the Nuclear Field, pp. 10-16 (1967) [Lang.: German], English bibliographic information (http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=4442292).
  • Arduini, G., et. al. “Physical specifications of clinical proton beams from a synchrotron” Med. Phys. 23 (6), pp. 939-951 (Jun. 1996).
  • Beeckman, W., et. al. “Preliminary design of a reduced cost proton therapy facility using a compact, high field isochronous cyclotron” Nuclear Instruments and Methods in Physics Reasearch B56/57, pp. 1201-1204 (1991).
  • Bellomo, G., et al., “The Superconducting Cyclotron Program at Michigan State University” Bulletin of the American Physical Society, vol. 25, No. 7, pp. 767 (Sep. 1980).
  • Benedikt, M. and Carli, C. “Matching to Gantries for Medical Synchrotrons” IEEE Proceedings of the 1997 Particle Accelerator Conference, pp. 1379-1381 (1997).
  • Bieth, C., et. al. “A Very Compact Protontherapy Facility Based on an Extensive Use of High Temperature Superconductors (HTS)” Cyclotrons and their Applications 1998, Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, Caen, pp. 669-672 (Jun. 14-19, 1998).
  • Bigham, C.B. “Magnetic Trim Rods for Superconducting Cyclotrons,” Nuclear Instruments and Methods (North-Holland Publishing Co.) 141 (1975), pp. 223-228.
  • Blackmore, E. W., et. al. “Operation of the Triumf Proton Therapy Facility” IEEE Proceedings of the 1997 Particle Accelerator Conferenc, vol. 3, pp. 3831-3833 (May 12-16, 1997).
  • Bloch, C. “The Midwest Proton Therapy Center” Application of Accelerators in Research and Industry, Proceedings of the Fourteenth Int'l. Conf., Part Two, pp. 1253-1255 (Nov. 1996).
  • Blosser, H., et. al. “A Compact Superconducting Cyclotron for the Production of High Intensity Protons” Proceedings of the 1997 Particle Accelerator Conference, vol. 1, pp. 1054-1056 (May 12-16, 1997).
  • Blosser, H., et al., “Advances in Superconducting Cyclotrons at Michigan State University”, Proceedings of the 11th International Conference on Cyclotrons and their Applications, pp. 157-167 (Oct. 1986), Tokyo.
  • Blosser, H., “Application of Superconductivity in Cyclotron Construction”, Ninth International Conference on Cyclotrons and their Applications, pp. 147-157 (Sep. 1981).
  • Blosser, H. “Applications of Superconducting Cyclotrons” Twelfth International Conference on Cyclotrons and Their Applications, pp. 137-144 (May 8-12, 1989).
  • Blosser, H., et al., “Characteristics of a 400 (Q2/A) MeV Super-Conducting Heavy-Ion Cyclotron”, Bulletin of the American Physical Society, p. 1026 (Oct. 1974).
  • Blosser, H. G. “Compact Superconducting Synchrocyclotron Systems for Proton Therapy” Nuclear Instruments & Methods in Physics Research, Section B40-41, Part II, pp. 1326-1330 (Apr. 1989).
  • Blosser, H.G., “Future Cyclotrons” AIP, The Sixth International Cyclotron Conference, pp. 16-32 (1972).
  • Blosser, H., et. al. “Medical Accelerator Projects at Michigan State Univ.” IEEE Proceedings of the 1989 Particle Accelerator Conference, vol. 2, pp. 742-746 (Mar. 20-23, 1989).
  • Blosser, H.G., “Medical Cyclotrons”, Physics Today, Special Issue Physical Review Centenary, pp. 70-73 (Oct. 1993).
  • Blosser, H., et al, National Superconducting Cyclotron Laboratory, Michigan State University, Report MSUCL-760, Nov. 2013.
  • Blosser, H., et al., “Preliminary Design Study Exploring Building Features Required for a Proton Therapy Facility for the Ontario Cancer Institute”, MSUCL-760a (Mar. 1991).
  • Blosser, H., Present and Future Superconducting Cyclotrons, Bulletin of the American Physical Society, vol. 32, No. 2, p. 171 (Feb. 1987), Particle Accelerator Conference, Washington, D.C. 1987.
  • Blosser, H., et al., “Problems and Accomplishments of Superconducting Cyclotrons”, Proceedings of the 14th International Conference, Cyclotrons and Their Applications, pp. 674-684 (Oct. 1995).
  • Blosser, H.G., “Program on the Coupled Superconducting Cyclotron Project”, Bulletin of the American Physical Society, vol. 26, No. 4, p. 558 (Apr. 1981).
  • Blosser, H., et al., “Superconducting Cyclotron for Medical Application”, IEEE Transactions on Magnetics, vol. 25, No. 2, pp. 1746-1754 (Mar. 1989).
  • Blosser, H.G., et al., “Superconducting Cyclotrons”, Seventh International Conference on Cyclotrons and their Applications, pp. 584-594 (Aug. 19-22, 1975).
  • Blosser, H.G., “Superconducting Cyclotrons at Michigan State University”, Nuclear Instruments & Methods in Physics Research, vol. B 24/25, part II, pp. 752-756 (1987).
  • Blosser, H. G. “Synchrocyclotron Improvement Programs” IEEE Transactions on Nuclear Science USA, vol. 16, No. 3, Part I, pp. 405-414 (Jun. 1969).
  • Blosser, H.G., “The Michigan State University Superconducting Cyclotron Program”, Nuclear Science, vol. NS-26, No. 2, pp. 2040-2047 (Apr. 1979).
  • Botha, A. H., et. al. “A New Multidisciplinary Separated-Sector Cyclotron Facility” IEEE Transactions on Nuclear Science, vol. NS-24, No. 3, pp. 1118-1120 (1977).
  • Chichili, D.R., et al., “Fabrication of Nb3Sn Shell-Type Coils with Pre-Preg Ceramic Insulation,” American Institute of Physics Conference Proceedings, AIP USA, No. 711, (XP-002436709, ISSN: 0094-243X), 2004, pp. 450-457.
  • Chong, C.Y., et al., Radiology Clinic North American 7, 3319 (1969).
  • Chu, et. al. “Instrumentation for Treatment of Cancer Using Proton and Light-ion Beams” Review of Scientific Instruments, 64 (8), pp. 2055-2122 (Aug. 1993).
  • Cole, et. al. “Design and Application of a Proton Therapy Accelerator”, Fermi National Accelerator Laboratory, IEEE, 1985.
  • Conradie, et. al. “Proposed New Facilities for Proton Therapy at iThemba Labs” Proceedings of EPAC, pp. 560-562 (2002).
  • C/E Source of Ions for Use in Sychro-Cyclotrons Search, Jan. 31, 2005, 9 pages.
  • Source Search Cites of U.S. and Foreign Patents/Published applications in the name of Mitsubishi Denki Kabushiki Kaisha and Containing the Keywords (Proton and Synchrocyclotron), 8 pages, Apr. 1957.
  • Coupland, . “High-field (5 T) pulsed superconducting dipole magnet” Proceedings of the Institution of Electrical Engineers, vol. 121, No. 7, pp. 771-778 (Jul. 1974).
  • Coutrakon, et. al. “A prototype beam delivery system for the proton medical accelerator at Loma Linda” Medical Physics, vol. 18(6), pp. 1093-1099 (Nov./Dec. 1991).
  • Coutrakon, G et al. “Proton Synchrotrons for Cancer Therapy” Application of Accelerators in Research and Industry—Sixteenth International Conf., American Institute of Physics, vol. 576, pp. 861-864 (Nov. 1-5, 2000).
  • “CPAC Highlights Its Proton Therapy Program at ESTRO Annual Meeting”, TomoTherapy Incorporated, Sep. 18, 2008, Madison, Wisconsin, pp. 1-2.
  • Dialog Search, Jan. 31, 2005 (18 pages).
  • “Indiana's mega-million proton therapy cancer center welcomes its first patients” [online] Press release, Health & Medicine Week, 2004, retrieved from NewsRx.com, Mar. 1, 2004, pp. 119-120.
  • Ishibashi, K. and McInturff, A., “Stress Analysis of Superconducting 10T Magnets for Synchrotron”, Proceedings of the Ninth International Cryogenic Engineering Conference, pp. 513-516 (May 11-14, 1982).
  • Ishibashi, K. and McInturff, A. “Winding Design Study of Superconducting 10 T Dipoles for a Synchrotron” IEEE Transactions on Magnetics, vol. MAG-19, No. 3, pp. 1364-1367 (May 1983).
  • Jahnke, A., et. al. “First Superconducting Prototype Magnets for a Compact Synchrotron Radiation Source in Operation” IEEE Transactions on Magnetics, vol. 24, No. 2 (Mar. 1988), pp. 1230-1232.
  • Jones, D.T.L. “Progress with the 200 MeV Cyclotron Facility at the National Accelerator Centre” Commission of the European Communities Radiation Protection Proceedings, Fifth Symposium on Neutron Dosimetry, vol. II, pp. 989-998 (Sep. 17-21, 1984).
  • Jones, D. T. L. “Present Status and Future Trends of Heavy Particle Radiotherapy” Cyclotrons and their Applications 1998, Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, pp. 13-20 (Jun. 14-19, 1998).
  • Jones, and Dershem . “Synchrotron Radiation from Proton in a 20 TEV, 10 TESLA Superconducting Super Collider” Proceedings of the 12th International Conference on High-Energy Accelerators, pp. 138-140 (Aug. 11-16, 1983).
  • Jones, D. T. L. and Mills, S. J. “The South African National Accelerator Centre: Particle Therapy and Isotope Production Programmes” Radiation Physics and Chemistry, vol. 51, Nos. 4-6, pp. 571-578 (Apr.-Jun. 1998).
  • Jones, D. T. L., et. al. “Status Report of the NAC Particle Therapy Programme” Stralentherapie und Onkologie, vol. 175, Suppl. II, pp. 30-32 (Jun. 1999).
  • Jongen, Y., et. al. “Progress report on the IBA-SHI small cyclotron for cancer therapy” Nuclear Instruments and Methods in Physics Research, Section B, vol. 79, issue 1-4, pp. 885-889 (1993).
  • Jongen, Y., et. al. “The proton therapy system for MGH's NPTC: equipment description and progress report” Bulletin du Cancer/Radiotherapie, Proceedings of the meeting of the European Heavy Particle Therapy Group, vol. 83, Suppl. 1, pp. 219-222 (1996).
  • Jongen, Y., et. al. “Development of a Low-cost Compact Cyclotron System for Proton Therapy” National Institute of Radiol. Sci,, No. 81, pp. 189-200 (1991).
  • Jongen, Y. et. al. “The proton therapy system for the NPTC: equipment description and progress report” Nuclear Instruments and methods in Physics Research, Section B, vol. 113, No. 1, pp. 522-525 (1996).
  • Kanai, et al., “Three-dimensional Beam Scanning for Proton Therapy,” Nuclear Instruments and Methods in Physic Research, Sep. 1, 1983, The Netherlands, vol. 214, No. 23, pp. 491-496.
  • Karlin, D.L., et al., “Medical Radiology” (Moscow) 28, 13 (1983).
  • Karlin, D.L., et al., “The State and Prospects in the Development of the Medical Proton Tract on the Synchrocyclotron in Gatchina”, Med. Radiol., Moscow, vol. 28(3), pp. 28-32 (Mar. 1983)(German with English Abstract on end of p. 32).
  • Kats, M.M. and Druzhinin, B.L. “Comparison of Methods for Irradiation Prone Patients” Atomic Energy, vol. 94, No. 2, pp. 120-123 (Feb. 2003).
  • Kats, M. M. and Onosovskii, K. K. “A Planar Magnetooptical System for the Irradiation of a Lying Patient with a Proton Beam from Various Directions” Instruments and Experimental Techniques, vol. 39, No. 1, pp. 127-131 (1996).
  • Kats, M. M. and Onosovskii, K. K. “A Simple, Compact, Flat System for the Irradiation of a Lying Patient with a Proton Beam from Different Directions” Instruments and Experimental Techniques, vol. 39, No. 1, pp. 132-134 (1996).
  • Koehler, A.M., et al., “Range Modulators for Protons and Heavy Ions,” Nuclear Instruments and Methods, vol. 131, pp. 437-440 (1975).
  • Khoroshkov, V. S., et. al. “Moscow Hospital-Based Proton Therapy Facility Design” Am. Journal Clinical Oncology: CCT, vol. 17, No. 2, pp. 109-114 (Apr. 1994).
  • Kim, J. and Yun, C. “A Light-Ion Superconducting Cyclotron System for Multi-Disciplinary Users” Journal of the Korean Physical Society, vol. 43, No. 3, pp. 325-331 (Sep. 2003).
  • Kim, J.W., “An Eight Tesla Superconducting Magnet for Cyclotron Studies,” Ph.D. Dissertation, Michigan State University, Department of Physics and Astronomy (1994).
  • Kim, J., et al., “Construction of 8T Magnet Test Stand for Cyclotron Studies”, IEEE Transactions on Applied Superconductivity, vol. 3, No. 1, pp. 266-268 (Mar. 1993).
  • Kim, J., et al., “Design Study of a Superconducting Cyclotron for Heavy Ion Therapy”, Cyclotrons and Their Applications 2001, Sixteenth International Conference, pp. 324-326 (May 13-17, 2001).
  • Kim, J. and Blosser, H., “Optimized Magnet for a 250 MeV Proton Radiotherapy Cyclotron”, Cyclotrons and Their Applications 2001, Sixteenth International Conference, pp. 345-347 (May 2001).
  • Kim, J.W., et al., “Trim Coil System for the Riken Cyclotron Ring Cyclotron”, Proceedings of the 1997 Particle Accelerator Conference, IEEE, vol. 3, pp. 214-235 (Dec. 1981). OR 3422-3424, 1998).
  • Kishida, N. and Yano, Y. “Beam Transport System for the Riken SSC (II)” Scientific Papers of the Institute of Physical and Chemical Research, vol. 75, No. 4, pp. 214-235 (Dec. 1981).
  • Koto, M. and Tsujii, H. “Future of Particle Therapy” Japanese Journal of Cancer Clinics, vol. 47, No. 1, pp. 95-98 (2001) [Lang.: Japanese], English abstract (http://sciencelinks.jp/j-east/article/200206/000020020601A0511453.php).
  • Kraft, G. et al., “Hadrontherapy in Oncology”, U. Amaldi and Larrsson, editors Elsevier Science, 1994.
  • Krevet, et al, “Design of a Strongly Curved Superconducting Bending Magnet for a Compact Synchrotron Light Source”, Advances in Cryogenic Engineering, vol. 33, pp. 25-32, 2013.
  • Larsson, B. “Biomedical Program for the Converted 200-MeV Synchrocyclotron at the Gustaf Werner Institute” Radiation Research, 104, pp. S310-S318 (1985).
  • Larsson, B., et al., Nature 182, 1222 (1958).
  • Lawrence, J.H., Cancer 10, 795 (1957).
  • Lawrence, J.H., et al., “Heavy particles in acromegaly and Cushing's Disease,” in Endocrine and Norendocrine Hormone Producing Tumors (Year Book Medical Chicago, 1973), pp. 29-61.
  • Lawrence, J.H., et al., “Successful Treatment of Acromegaly: Metabolic and Clinical Studies in 145 Patients”, The Journal of Clinical Endrocrinology and Metabolism, vol. 31, No. 2, Aug. 1970.
  • Lawrence, J.H., et al., Treatment of Pituitary Tumors, (Excerpta medica, Amsterdam/American Elsevier, New York, 1973), pp. 253-262.
  • Lecroy, W., et al., “Viewing Probe for High Voltage Pulses”, Review of Scientific Instruments USA 31(12), p. 1354 (Dec. 1960).
  • Linfoot, J.A., et al., “Acromegaly,” in Hormonal Proteins and Peptides, edited by C.H. Li, (1975), pp. 191-246.
  • Literature Author and Keyword Search, Feb. 14, 2005 (44 pages).
  • Literature Author and Keyword Searches (Synchrotron), Jan. 25, 2005 (78 pages).
  • Literature Keyword Search, Jan. 24, 2005 (96 pages).
  • Literature Search, Jan. 26, 2005 (36 pages).
  • Literature Search and Keyword Search for Synchrocyclotron, Jan. 25, 2005 (68 pages).
  • Literature Search by Company Name/Component Source, Jan. 24, 2005 (111 pages).
  • “LLNL, UC Davis Team Up to Fight Cancer”, Lawrence Livermore National Laboratory, Apr. 28, 2006, SF-06-04-02, Livermore, California, pp. 1-4.
  • Mandrillon, P. “High Energy Medical Accelerators” EPAC 90, 2nd European Particle Accelerator Conference, vol. 2, (Jun. 12-16, 1990), pp. 54-58.
  • Marti, F., et al., “High Intensity Operation of a Superconducting Cyclotron”, Proceedings of the 14the International Conference, Cyclotrons and Their Applications, pp. 45-48 (Oct. 1995).
  • Martin, P. “Operational Experience with Superconducting Synchrotron Magnets” Proceedings of the 1987 IEEE Particle Accelerator Conference, vol. 3 of 3, pp. 1379-1382 (Mar. 16-19, 1987).
  • Meot, F., et. al. “ETOILE Hadrontherapy Project, Review of Design Studies” Proceedings of EPAC 2002, pp. 2745-2747 (2002).
  • Miyamoto, S., et. al. “Development of the Proton Therapy System” The Hitachi Hyoron, vol. 79, 10, pp. 775-779 (1997) [Lang: Japanese], English abstract (http://www.hitachi.com/rev/1998/revfeb98/rev4706.htm).
  • Montelius, A., et. al. “The Narrow Proton Beam Therapy Unit at the Svedberg Laboratory in Uppsala” ACTA Oncologica, vol. 30, pp. 739-745 (1991).
  • Moser, H.O., et al., “Nonlinear Beam Optics with Real Fields in Compact Storage Rings”, Nuclear Instruments & Methods in Physics Research/Section B, B30, Feb. 1988, No. 1, pp. 105-109.
  • National Cancer Institute Funding (Senate—Sep. 21, 1992) (www.thomas.loc.gov/cgi-bin/query/z?r102:S21SE2-712 (2 pages).
  • Nicholson, J. “Applications of Proton Beam Therapy” Journal of the American Society of Radiologic Technologists, vol. 67, No. 5, pp. 439-441 (May/Jun. 1996).
  • Nolen, J.A., et al., “The Integrated Cryogenic—Superconducting Beam Transport System Planned for MSU”, Proceedings of the 12th International Conference on High-Energy Accelerators, pp. 549-551 (Aug. 1983).
  • Norimine, T., et. al. “A Design of a Rotating Gantry with Easy Steering for Proton Therapy” Proceedings of EPAC 2002, pp. 2751-2753 (2002).
  • Okumura, T., et. al. “Overview and Future Prospect of Proton Radiotherapy” Japanese Journal of Cancer Clinics, vol. 43, No. 2, pp. 209-214 (1997) [Lang.: Japanese].
  • Okumura, T., et. al. “Proton Radiotherapy” Japanese Journal of Cancer and Chemotherapy, 10. 20, No. 14, pp. 2149-2155 (1993) [Lang.: Japanese].
  • Outstanding from Search Reports, “Accelerator of Polarized Portons at Fermilab,” 20 pages, 2005.
  • Palmer, R. and Tollestrup, A. V. “Superconducting Magnet Technology for Accelerators” Annual Review of Nuclear and Particle Science, vol. 34, pp. 247-284 (1984).
  • Patent Assignee and Keyword Searches for Synchrocyclotron, Jan. 25, 2005 (77 pages).
  • “Patent Assignee Search Paul Scherrer Institute,” Library Services at Fish & Richardson P.C., Mar. 20, 2007 (40 pages).
  • “Patent Prior Art Search for ‘Proton Therapy System’,” Library Services at Fish & Richardson P.C., Mar. 20, 2007 (46 pages).
  • Pavlovic, M. “Beam-optics study of the gantry beam delivery system for light-ion cancer therapy” Nuclear Instruments and Methods in Physics Research, Section A, vol. 399, No. 2, pp. 439-454(16) (Nov. 1997).
  • Pedroni, E. “Accelerators for Charged Particle Therapy: Performance Criteria from the User Point of View” Cyclotrons and their Applications, Proceedings of the 13th International Conference, pp. 226-233 (Jul. 6-10, 1992).
  • Pedroni, E. “Latest Developments in Proton Therapy” Proceedings of EPAC 2000, pp. 240-244 (2000).
  • Pedroni, E., et. al. “The 200-MeV proton therapy project at the Paul Scherrer Institute: Conceptual design and practical realization” Medical Physics, vol. 22, No. 1, pp. 37-53 (Jan. 1995).
  • Pedroni, E., et. al. “A Novel Gantry for Proton Therapy at the Paul Scherrer Institute” Cycloctrons and Their Applications 2001: Sixteenth International Conference. AIP Conference Proceedings, vol. 600, pp. 13-17 (2001).
  • Pedroni, E. and Enge, H. “Beam optics design of compact gantry for proton therapy” Medical & Biological Engineering & Computing, vol. 33, No. 3, pp. 271-277 (May 1995).
  • Pedroni, E. and Jermann, M. “SGSMP: Bulletin Mar. 2002 PROSCANProject, Progress Report on the Proscan Project of PSI” [online] retrieved from www.sgsmp.ch/protA23.htm, (5 pages) Mar. 2002.
  • Potts, R., et. al. “MPWP6-Therapy III: Treatment Aids and Techniques” Medical Physics, vol. 15, No. 5, p. 798 (Sep./Oct. 1988).
  • Pourrahimi, S. et al., “Powder Metallurgy Processed Nb3Sn(Ta) Wire for High Field NMR magnets,” IEEE Transactions on Applied Superconductivity, vol. 5, No. 2, (Jun. 1995), pp. 1603-1606.
  • Prieels, D., et. al. “The IBA State-of-the-Art Proton Therapy System, Performances and Recent Results” Application of Accelerators in Research and industry—Sixteenth Int'l. Conf., American Institute of Physics, vol. 576, pp. 857-860 (Nov. 1-5, 2000).
  • Rabin, M. S. Z., et. al. “Compact Designs for Comprehensive Proton Beam Clinical Facilities” Nuclear Instruments & Methods in Physics Research, Section B, vol. 40-41, Part II, pp. 1335-1339 (Apr. 1989).
  • Research & Development Magazine, “Proton Therapy Center Nearing Completion”, vol. 41, No. 9, Aug. 1999 (2 pages)(www.rdmag.com).
  • RetroSearch “Berkeley 88-Inch Cyclotron ‘RF’ or ‘Frequency Control’,” Jan. 21, 2005 (36 pages).
  • RetroSearch “Berkeley 88-Inch Cyclotron,” Jan. 24, 2005 (170 pages).
  • RetroSearch “Bernard Gottschalk, Cyclotron, Beams, Compensated Upstream Modulator, Compensated Scatter,” Jan. 21, 2005 (20 pages).
  • RetroSearch “Cyclotron with ‘RF’ or ‘Frequency Control’,” Jan. 21, 2005 (49 pages).
  • RetroSearch Gottschalk, Bernard, Harvard Cyclotron Wheel, Jan. 21, 2005 (20 pages).
  • RetroSearch “Loma Linda University, Beam Compensation Foil Wedge,” Jan. 21, 2005 (15 pages).
  • RetroSearch “Loma Linda University Beam Compensation,” Jan. 21, 2005 (60 pages).
  • Revised Patent Keyword Search, Jan. 25, 2005 (88 pages).
  • Rifuggiato, D., et. al. “Status Report of the LNS Superconducting Cyclotron” Nukleonika, vol. 48, pp. S131-S134 (Supplement 2, 2003).
  • Rode, C. H. “Tevatron Cryogenic System” Proceedings of the 12th International Conference on High-energy Accelerators, Fermilab, pp. 529-535 (Aug. 11-16, 1983).
  • Schillo, M., et. al. “Compact Superconducting 250 MeV Proton Cyclotron for the PSI Proscan Proton Therapy Project” Cyclotrons and Their Applications 2001, Sixteenth International Conference, pp. 37-39 (2001).
  • Schneider et al., “Superconducting Cyclotrons,” IEEE Transactions on Magnetics, vol. MAG-11, No. 2, Mar. 1975, New York, pp. 443-446.
  • Schneider, R., et al., “Nevis Synchrocyclotron Conversion Program—RF System,” IEEE Transactions on Nuclear Science USA ns 16(3) pp. 430-433 (Jun. 1969).
  • Schreuder, H.W. “Recent Developments in Superconducting Cyclotrons” Proceedings of the 1995 Particle Accelerator Conference, vol. 1, pp. 317-321 (May 1-5, 1995).
  • Schreuder, A. N., et. al. “The Non-orthogonal Fixed Beam Arrangement for the Second Proton Therapy Facility at the National Accelerator Centre” Application of Accelerators in Research and Industry, American Institute of Physics, Proceedings of the Fifteenth International Conference, Part Two, pp. 963-966 (Nov. 1998).
  • Schubert, J. R. “Extending the Feasibility Boundary of the Isochronous Cyclotron” Dissertation submitted to Michigan State University, 1997, Abstract http://adsabs.harvard.edu/abs/1998PhDT.......147S.
  • Schubert, J. and Blosser, H. “Conceptual Design of a High Field Ultra-Compact Cyclotron for Nuclear Physics Research” Proceedings of the 1997 Particle Accelerator Conference, vol. 1, pp. 1060-1062 (May 12-16, 1997).
  • Shelaev, I. A., et. al. “Design Features of a Model Superconducting Synchrotron of JINR” Proceedings of the 12th International Conference on High-energy Accelerators, pp. 416-418 (Aug. 11-16, 1983).
  • Shintomi, T., et. al. “Technology and Materials for the Superconducting Super Collider (SSC) Project” [Lang.: Japanese], The Iron and Steel Institute of Japan 00211575, vol. 78, No. 8 (19920801), pp. 1305-1313, http://ci.nii.ac.jp/naid/110001493249/en/ , 1992.
  • Sisterson, J. M. “World Wide Proton Therapy Experience in 1997” The American Insitute of Physics, Applications of Accelerators in Research and Industry, Proceedings of the Fifteenth International Conference, Part Two, pp. 959-962 (Nov. 1998).
  • Sisterson, J. M. “Clinical Use of Proton and Ion Beams From a World-Wide Perspective” Nuclear Instruments and Methods in Physics Research, Section B, vols. 40-41, pp. 1350-1353 (1989).
  • Slater, J. M., et. al. “Development of a Hospital-Based Proton Beam Treatment Center” International Journal of Radiation Oncology Biology Physics, vol. 14, No. 4, pp. 761-775 (Apr. 1988).
  • Slater, J. M., et. al. “Developing a Clinical Proton Accelerator Facility: Consortium-Assisted Technology Transfer” Conference Record of the 1991 IEEE Particle Accelerator Conference: Accelerator Science and Technology, vol. 1, pp. 532-536 (May 6-9, 1991).
  • Smith, A., et. al. “The Northeast Proton Therapy Center at Massachusetts General Hospital” Journal of Brachytherapy International, pp. 137-139 (Jan. 1997).
  • Snyder, S. L. and Marti, F. “Central region design studies for a proposed 250 MeV proton cyclotron” Nuclear Instruments and Methods in Physics Research, Section A, vol. 355, pp. 618-623 (1995).
  • Soga, F. “Progress of Particle Therapy in Japan” Application of Accelerators in Research and Industry, American Institute of Physics, Sixteenth International Conference, pp. 869-872 (Nov. 2000).
  • Spiller, P., et. al. “The GSI Synchrotron Facility Proposal for Acceleration of High Intensity Ion and Proton Beams” Proceedings of the 2003 Particle Accelerator Conference, vol. 1, pp. 589-591 (May 12-16, 2003).
  • Stanford, A.L., et al., “Method of Temperature Control in Microwave Ferroelectric Measurements,” Sperry Microwave Electronics Company, Clearwater, Florida, Sep. 19, 196 (1 page), 2013.
  • Superconducting Cyclotron Contract awarded by Paul Scherrer Institute (PSI), Villigen, Switzerland, http://www.accel.de/News/superconducting_cyclotron_contract.html Feb. 3, 2005.
  • Tadashi, I., et al., “Large superconducting super collider (SSC) in the planning and materials technology”, vol. 78, No. 8 (Aug. 1, 1992), pp. 1305-1313, The Iron and Steel Institute of Japan 00211575.
  • Takada, Yoshihisa Tsukumba, “A review of rotating gantries for heavy charged particle therapy,” Symposium of Research Center for Charged Particle Therapy on Fundamental development of the charged particle therapy, Chiba (Japan), Nov. 13-14, 2001.
  • Takada, Y. “Conceptual Design of a Proton Rotating Gantry for Cancer Therapy” Japanese Journal of Medical Physics, vol. 15, No. 4, pp. 270-284 (1995).
  • Takayama, T., et al., “Compact Cyclotron for Proton Therapy,” Proceedings of the 8th Symposium on Accelerator Science and Technology, Japan (Nov. 25-27, 1991) pp. 380-382.
  • Teng, L. C. “The Fermilab Tevatron” Coral Gables 1981, Proceedings, Gauge Theories, Massive Neutrinos, and Proton Decay, pp. 43-62 (1981).
  • “The Davis 76-Inch Isochronous Cyclotron”, Beam On: Crocker Nuclear Laboratory, University of California, 2013.
  • The Journal of Practical Pharmacy, vol. 46, No. 1, 1995, pp. 97-103. [Japanese].
  • “The K100 Neutron-therapy Cyclotron,” National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.edu/tech/accelerators/k100 , Feb. 2005.
  • “The K250 Proton therapy Cyclotron,” National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.edu/tech/accelerators/k250.html , Feb. 2005.
  • “The K250 Proton-therapy Cyclotron Photo Illustration,” National Superconducting Cyclotron Laboratory at Michigan State University (NSCL), retrieved from: http://www.nscl.msu.edu/media/image/experimental-equipment-technology/250.html , Feb. 2005.
  • Tobias, C.A., et al., Cancer Research 18, 121 (1958).
  • Tom, J. L. “The Use of Compact Cyclotrons for Producing Fast Neutrons for Therapy in a Rotatable Isocentric Gantry” IEEE Transaction on Nuclear Science, vol. 26, No. 2, pp. 2294-2298 (Apr. 1979).
  • Toyoda, E., “Proton Therapy System”, Sumitomo Heavy Industries, Ltd., 2013.
  • Trinks, U., et. al. “The Tritron: A Superconducting Separated-Orbit Cyclotron” Nuclear Instruments and Methods in Physics Research, Section A, vol. 244, pp. 273-282 (1986).
  • Tsuji, H., “Cancer Therapy by Proton Beam: Latest State and Future Prospects”, Isotope News, No. 459, pp. 2-7 (1992).
  • Tsuji, H. “The Future and Progress of Proton Beam Radiotherapy” Journal of Japanese Society for Therapeutic Radiology and Oncology, vol. 6, No. 2, pp. 63-76 (1994).
  • UC Davis School of Medicine, “Unlikely Partners Turn Military Defense into Cancer Offense”, Current Issue Summer 2008, Sacramento, California, pp. 1-2.
  • Umegaki, K., et. al. “Development of an Advanced Proton Beam Therapy System for Cancer Treatment” Hitachi Hyoron, vol. 85, No. 9, pp. 605-608 (2003) [Lang.: Japanese], English abstract, http://www.hitachi.com/ICSFiles/afieldfile/2004/06/01/r2003_04_104.pdf or http://www.hitachi.com/rev/archive/2003/2005649_12606.html (full text) [Hitachi, vol. 52, No. 4 Dec. 2003].
  • Umezawa, M., et. al. “Beam Commissioning of the new Proton Therapy System for University of Tsukuba” Proceedings of the 2001 Particle Accelerator Conference, vol. 1, pp. 648-650 (Jun. 18-22, 2001).
  • van Steenbergen, A. “The CMS, a Cold Magnet Synchrotron to Upgrade the Proton Energy Range of the BNL Facility” IEEE Transactions on Nuclear Science, vol. 18, Issue 3, pp. 694-698 (Jun. 1971).
  • van Steenbergen, A. “Superconducting Synchroton Development at BNL” Proceedings of the 8th International Conference on High-Energy Accelerators CERN 1971, pp. 196-198 (1971).
  • Vandeplassche, D., et. al. “235 MeV Cyclotron for MGH's Northeast Proton Therapy Center (NPTC): Present Status” EPAC 96, Fifth European Partical Accelerator Conference, vol. 3, pp. 2650-2652 (Jun. 10-14, 1996).
  • Vorobiev, L.G., et al., “Concepts of a Compact Achromatic Proton Gantry with a Wide Scanning Field”, Nuclear Instruments and Methods in Physics Research, Section A., vol. 406, No. 2, pp. 307-310 (1998).
  • Vrenken, H., et. al. “A Design of a Compact Gantry for Proton Therapy with 2D-Scanning” Nuclear Instruments and Methods in Physics Research, Section A, vol. 426, No. 2, pp. 618-624 (1999).
  • Wikipedia, “Cyclotron” http://en.wikipedia.org/wiki/Cyclotron (originally visited Oct. 6, 2005, revisited Jan. 28, 2009)(7 pages).
  • Wikipedia, “Synchrotron” http://en.wikipedia.org/wiki/Synchrotron (originally visited Oct. 6, 2005, revisited Jan. 28, 2009)(7pages).
  • Worldwide Patent Assignee Search, Jan. 24, 2005 (224 pages).
  • Worldwide Patent Keyword Search, Jan. 24, 2005 (94 pages).
  • Wu, X., “Conceptual Design and Orbit Dynamics in a 250 MeV Superconducting Synchrocyclotron,” Ph.D. Dissertation, Michigan State University, Department of Physics and Astronomy (1990).
  • York, R.C., et al., “Present Status and Future Possibilities at NSCL-MSU”, EPAC 94, Fourth European Particle Accelerator Conference, pp. 554-556 (Jun. 1994).
  • York, R.C., et al., “The NSCL Coupled Cyclotron Project—Overview and Status”, Proceedings of the Fifteenth International Conference on Cyclotrons and their Applications, pp. 687-691 (Jun. 1998).
  • Yudelev, M., et. al. “Hospital Based Superconducting Cyclotron for Neutron Therapy: Medical Physics Perspective” Cyclotrons and their applications 2001, 16th International Conference. American Institute of Physics Conference Proceedings, vol. 600, pp. 40-43 (May 13-17, 2001) http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=20468164 http://adsabs.harvard.edu/abs/2001AIPC..600...40Y http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=APCP- CS000600000001000040000001&idtype=cvips&gifs=yes.
  • Zherbin, E. A., et al., “Proton Beam Therapy at the Leningrad Synchrocyclotron (Clinicomethodological Aspects and Therapeutic Results)”, pp. 17-22, Aug. 1987, vol. 32(8)(German with English abstract on pp. 21-22).
  • 18th Japan Conference on Radiation and Radioisotopes [Japanese], Nov. 25-27, 1987, 9 pages.
  • “510(k) Summary: Ion Beam Applications S.A.”, FDA, Apr. 13, 2001.
  • “510(k) Summary: Optivus Proton Beam Therapy System”, Jul. 21, 2000, 5 pages.
  • U.S. Appl. No. 11/601,056, filed Nov. 17, 2006.
  • Flanz, et al., “Operation of a Cyclotron Based Proton Therapy Facility”, Massachusetts General Hospital, Boston, MA 02114, pp. 1-4, 2013.
  • Resmini, F., “Design Characteristics of the K=800 Superconducting Cyclotron at M.S.U.”, Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824, IEEE Transaction on Nuclear Science, vol. NS-26, No. 2, Apr. 1979 (8 pages).
  • European Search Report from application No. EP 06838033.6 (PCT/US2006/044853) mailed May 11, 2009 (69 pages).
  • European Patent Office communication for application No. 06838033.6, patent No. 1949404, mailed Aug. 5, 2009 (1 page).
  • Invitation to Pay Additional Fees and, where applicable, Protest Fees with partial search report for application No. PCT/US2008/077513 mailed Jul. 3, 2009 (62 pages).
  • Office action and response history of U.S. Appl. No. 11/601,056 to Aug. 24, 2009.
  • International Search Report and Written Opinion mailed Oct. 1, 2009 in PCT application No. PCT/US2008/077513 (73 pages).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2008/084695, mailed Jun. 10, 2010 (10 pages).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2008/084699, mailed Jun. 10, 2010 (8 pages).
  • International Preliminary Report on Patentability from PCT application No. PCT/US2007/086109, mailed Jun. 10, 2010 (7 pages).
  • European Patent Office communication from European application No. 07868958.5, mailed Jul. 16, 2010 (2 pages).
  • Voluntary amendment filed Apr. 18, 2011 in corresponding Chinese application No. CN200780102281.X , including English translation of claim amendments (10 pages).
  • Non Final Office Action from U.S. Appl. No. 12/618,297 mailed May 13, 2011 (44 pages).
  • Response to Office Action issued Aug. 20, 2010 in U.S. Appl. No. 11/948,359, filed Feb. 22, 2011 (17 pages).
  • Non Final Office Action from U.S. Appl. No. 11/948,359 mailed Aug. 20, 2010 (12 pages).
  • Non Final Office Action from U.S. Appl. No. 12/275,103 mailed Feb. 1, 2011 (6 pages).
  • Response to Non Final Office Action issued Feb. 1, 2011 in U.S. Appl. No. 12/275,103, filed May 2, 2011 (13 pages).
  • European Search Report from corresponding European application No. 11165422.4 mailed Aug. 8, 2011 (118 pages).
  • European Search Report from corresponding European application No. 11165423.2 mailed Aug. 8, 2011 (118 pages).
  • European Communication from corresponding European application No. 11165422.4 mailed Sep. 2, 2011 (5 pages).
  • European Communication from corresponding European application No. 11165423.2 mailed Sep. 2, 2011 (5 pages).
  • Chinese Office action from Chinese application No. 200680051421.0 issued Aug. 22, 2011 (4 pages).
  • Chinese Office action from Chinese application No. 200680051421.0 issued Mar. 21, 2011 (6 pages).
  • Chinese Office action from Chinese application No. 200680051421.0 issued Dec. 25, 2009 (8 pages).
  • Canadian Office action from Canadian application No. 2,629,333 issued May 11, 2011 (2 pages).
  • Canadian Office action from Canadian application No. 2,629,333 issued Aug. 30, 2010 (5 pages).
  • European Communication from European application No. 06838033.6 mailed Apr. 20, 2010 (7 pages).
  • European Patent Office communication from European application No. 08855024.9, mailed Jul. 30, 2010 (2 pages).
  • European Patent Office communication from European application No. 08856764.9, mailed Jul. 30, 2010 (2 pages).
  • Chinese Office action from Chinese application No. 200880125918.1, mailed Sep. 15, 2011 (111 pages).
  • Chinese Office action from Chinese application No. 200880125832.9, mailed Sep. 22, 2011 (11 pages).
  • Response to Chinese Office action of Jan. 25, 2010 in Chinese application No. 200680051421.0, filed Jun. 24, 2010 (34 pages).
  • Office action from U.S. Appl. No. 11/948,359, mailed Aug. 20, 2010 (12 pages).
  • Response to European Communication of Apr. 20, 2010, from European application No. 06838033.6, filed Nov. 2, 2010 (13 pages).
  • European Communication from European application No. 07868958.5, mailed Nov. 26, 2010 (50 pages).
  • Response to European Communication of Jul. 16, 2010 in European application No. 07868958.5 filed Aug. 26, 2010 (9 pages).
  • Response to European Communication of Nov. 26, 2010 in European application No. 07868958.5, filed Mar. 28, 2011 (9 pages).
  • Schubert and Blosser, “Progress Toward an Experiment to Study the Effect of RF Grounding in an Internal Ion Source on Axial Oscillations of the Beam in a Cyclotron”, National Superconducting Cyclotron Laboratory, Michigan State University, Report MSUCL-760, CP600, Cyclotrons and Their Applications 2001, Sixteenth International Conference, 2001 pp. 274-276.
  • Cuttone, G., “Applications of a Particle Accelerators in Medical Physics” Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali del Sud, V.S. Sofia, 44 Cantania, Italy, Jan. 2010 (17 pages).
  • Source Search Cites of U.S. and Foreign Patents/Published applications in the name of Mitsubishi Denki Kabushiki Kaisha and Containing the Keywords (Proton and Synchrocyclotron), Jan. 2005, 8 pages.
  • Flanz, et al., “Operation of a Cyclotron Based Proton Therapy Facility”, Massachusetts General Hospital, Boston, MA, 2010, pp. 1-4.
  • Krevet, et al, “Design of a Strongly Curved Superconducting Bending Magnet for a Compact Synchrotron Light Source”, Advances in Cryogenic Engineering, vol. 33, pp. 25-32, 1988.
  • Stanford, A.L., et al., “Method of Temperature Control in Microwave Ferroelectric Measurements,” Sperry Microwave Electronics Company, Clearwater, Florida, Sep. 19, 1960 (1 page).
  • Tadashi, I., et al., “Large superconducting super collider (SSC) in the planning and materials technology”, vol. 78, No. 8 (Aug. 1992), pp. 1305-1313, The Iron and Steel Institute of Japan 00211575.
  • “The Davis 76-Inch Isochronous Cyclotron”, Beam On: Crocker Nuclear Laboratory, University of California, Feb. 9, 2009 (1 page).
  • Badano et al., Proton-Ion Medical Machine Study (PIMMS) Part I, PIMMS, Jan. 1999, 238 pages.
  • “Beam Delivery and Properties” Journal of the ICRU, vol. 7 No. 2, 2007, 20 pages.
  • Peggs et al. “A Survey of Hadron Therapy Accelerator Technologies” Particle Accelerator Conference, Jun. 25-29, 2007, 7 pages.
  • Pedroni et al., “Latest Developments in Proton Therapy” Proceedings of EPAC, Vienna Austria, 2000, 5 pages.
  • Collins, et al., “The Indiana University Proton Therapy System”, Proceedings of EPAC 2006, Edinburgh, Scotland, 3 pages.
  • Paganetti et al., “Proton Beam Radiotherapy—The State of the Art” Springer Verlag, Heidelberg, ISBN 3-540-00321-5, Oct. 2005, 36 pages.
  • Pedroni, “Status of Proton Therapy: results and future trends” Paul Scherrer Institute, Division of Radiation Medicine, 5 pages, 2013.
  • Kimstrand, “Beam Modelling for Treatment Planning of Scanned Proton Beams” Digital Comprehensive Summaries of Uppsala dissertations from the Faculty of Medicine 330, Uppsala Universitet, 2008, 58 pages.
  • Marchand et al., “IBA Proton Pencil Beam Scanning: an Innovative Solution for Cancer Treatement”, Proceedings of EPAC 2000, Vienna, Austria, 3 pages.
  • Alonso, “Magnetically Scanned Ion Beams for Radiation Therapy” Accelerator & Fusion Research Division, Lawrence Berkeley Laboratory, Berkeley, CA, Oct. 1988, 13 pages.
  • Moyers et al., “A Continuously Variable Thickness Scatterer for Proton Beams Using Self-compensating Dual Linear Wedges” Loma Linda University Medical Center, Dept. of Radiation Medicine, Loma Linda, CA, Nov. 2, 1992, 21 pages.
  • Chu et al., “Performance Specifications for Proton Medical Facility”, Lawrence Berkeley Laboratory, University of California, Mar. 1993, 128 pages.
  • Chu, “Instrumentation in Medical Systems” Accelerator and Fusion Research Division, Lawrence Berkeley Laboratory, University of California, Berkeley, CA, May 1995, 9 pages.
  • Tilly et al., “Development and verification of the pulsed scanned proton beam at The Svedberg Laboratory in Uppsala”, Phys. Med. Biol. 52, 2007, pp. 2741-2754.
  • Bimbot, “First Studies of the Extenral Beam from the Orsay S.C. 200 MeV” Institut de Physique Nucleaire, BP 1, Orsay, France, IEEE, 1979, pp. 1923-1926.
  • Cosgrove et al., “Microdosimetric Studies on the Orsay Proton Synchrocyclotron at 73 and 200 MeV”, Radiation Protection Dosimetry, vol. 70, Nos. 1-4, pp. 493-496, 1997.
  • Laisne et al., “The Orsay 200 MeV Synchrocyclotron” IEEE Transactions on Nuclear Science, vol. NS-26, No. 2, Apr. 1979, pp. 1919-1922.
  • Lin et al., “Principles and 10 year experience of the beam monitor system at the psi scanned proton therapy facility” Center for Proton Radiation Therapy, Paul Scherrer Institute, Switzerland, 21 pages, 2013.
  • Chinese Office Action for Chinese application 200880125918.1 mailed Sep. 15, 2011 (15pages).
  • Response to Chinese Office Action mailed Sep. 15, 2011 in Chinese application 200880125918.1, filed Mar. 29, 2012 (26 pages).
  • Chinese Office Action for Chinese application 200880125918.1 mailed May 30, 2012 (10 pages).
  • Response to Chinese Office Action mailed May 30, 2012 in Chinese application 200880125918.1, filed Aug. 14, 2012 (19 pages).
  • Chinese Office Action for Chinese application 200880125918.1 mailed Dec. 7, 2012 (10 pages).
  • Japanese Office action with English translation from corresponding Japanese application No. 2010-536130 issued Jun. 4, 2013 (8 pages).
  • Timmer, Jan, “The ACCEL Single Room Proton Therapy Facility” ACCEL Instruments GmbH, PTCOG 45, Oct. 7-11, 2006, Houston, Texas (18 pages).
  • Renner, T.R., et al., “Preliminary Results of a Raster Scanning Beam Delivery System”, IEEE, 1989 (3 pages).
  • Pardo, J., et al., “Simulation of the Performance of the CNAO facility's Beam Delivery System”, PTCOG 46, Zibo, China, May 21, 2007 (17 pages).
  • “Single Room Proton Therapy Facility”, ACCEL, Oct. 2006 (1 page).
  • Flanz, J, et al., “Scanning Beam Technologies”, PTCOG 2008 (28 pages).
  • Lin, S., et al., “Principles and 10 Year Experience of the Beam Monitor System at the PSI Scanned Proton Therapy Facility”, Center for Proton Radiation Therapy, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland, 2007 (21 pages).
  • Tilly, et al., “Development and verification of the pulsed scanned proton beam at The Svedberg Laboratory in Uppsala”, Physics in Medicine and Biology, Phys. Med. Biol. 52, pp. 2741-2454, 2007.
  • Response with English translation to Japanese Office action mailed Feb. 10, 2014 from corresponding Japanese application No. 2010-536130, filed May 8, 2014 (15 pages).
  • Japanese Office Action with English translation from corresponding Japanese application No. 2010-536130 issued on Feb. 10, 2014 (9 pages).
  • International Search Report and Written Opinion from corresponding PCT application No. PCT/US2008/084695 mailed on Jan. 26, 2009 (13 pages).
  • European Search Report from corresponding European application 08855024.9 dated Jun. 6, 2014 (5 pages).
  • European Communication from corresponding European application 08855024.9 dated Jul. 29, 2014 (10 pages).
  • Kleeven, W., “Injection and Extraction for Cyclotrons”, Ion Beam Applications (IBA), Proceedings of the Specialised CERN Accelerator School on Small Accelerators, Oct. 26, 2006, pp. 271-296, XP055119328, Geneva, Switzerland, Retrieved from the Internet: URL:http://cds.cern.ch/record/1005057/files/p271.pdf, [retrieved on May 21, 2014].
  • YamayaA, T., et al.: “A Small Cold Cathode Heavy Ion Source for a Compact Cyclotron”, Nuclear Instruments and Methods in Physics Research, vol. 226, Jan. 1, 1984, pp. 219-222, XP055119506.
  • Welton, R. F., “RF-Plasma Coupling Schemes for the SNS Ion Source”, AIP Conference Proceedings, vol. 694, Jan. 1, 2003, pp. 431-438, XP055119965.
  • Taiwanese Office Action with English translation from corresponding Taiwanese application 097144549 dated Sep. 4, 2014 (20 pages).
Patent History
Patent number: RE48317
Type: Grant
Filed: Mar 1, 2017
Date of Patent: Nov 17, 2020
Assignee: Mevion Medical Systems, Inc. (Littleton, MA)
Inventors: Kenneth P. Gall (Somerville, MA), Gerrit Townsend Zwart (Durham, NH)
Primary Examiner: Angela M Lie
Application Number: 15/446,633
Classifications
Current U.S. Class: Cyclotrons (313/62)
International Classification: H05H 7/00 (20060101); H05H 13/02 (20060101);