Triazolo[4,3-a]pyridin-3(2H)-ones

Abstract

Triazolo[4,3-a]pyridin-3-(2H)-one derivatives containing a 4-(optionally substituted phenyl)piperazinyl component attached to the two position of the triazolo-[4,3-a]pyridine component via a divalent radical such as --(CH.sub.2).sub.5 --, --(CH.sub.2).sub.6 --, --CH.sub.3 CH(CH.sub.3)CH.sub.2 --, --CH.sub.2 C(CH.sub.3).sub.2 CH.sub.2 --, --CH.sub.2 CH.dbd.CHCH.sub.2 --, --CH.sub.2 C.tbd.CCH.sub.2 --, --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 -- or a divalent cycloalkylene radical of 3 to 6 carbon atoms are disclosed. The compounds are useful in that they exhibit central nervous system pharmacological properties in standard laboratory tests considered predictive of analgetics, anti-psychotic (neuroleptics), antidepressant and antianxiety utility. Examples of specific embodiments of the invention are compounds having the formula______________________________________ ##STR1## Y R ______________________________________ ##STR2## 3-Cl ##STR3## H ##STR4## 3-Cl ##STR5## 3-CF.sub.3 ##STR6## 4-F CH.sub.2 CHCHCH.sub.2 3-Cl CH.sub.2 CCCH.sub.2 3-Cl (CH.sub.2).sub.5 3-Cl (CH.sub.2).sub.5 4-CH.sub.3 O (CH.sub.2).sub.5 2-CH.sub.3 (CH.sub.2).sub.6 3-Cl CH.sub.2 C(CH.sub.3).sub.2 CH.sub.2 3-Cl CH.sub.2 CH(CH.sub.3)CH.sub.2 3-CF.sub.3 CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 3-Cl ______________________________________

Description