Cyanoethylation of hydantoins
an improved process for the manufacture of a 3-.beta.-cyanoethyl- or a 1,3-di(.beta.-cyanoethyl)-5,5-disubstituted hydantoin, by reacting acrylonitrile and a 5,5-disubstituted hydantoin in the presence of a base catalyst in a solvent media composed of a secondary and/or tertiary alcohol having up to 5 carbon atoms and a boiling point from between about 80.degree.-135.degree. C as a reaction solvent. The alcohol reaction solvent may be used for crystallization of the cyanoethylated product.The solvent media can for example be selected from the group of isopropanol, 2-methyl-2-butanol, 3-methyl-2-butanol, 2-pentanol, 3-pentanol, tertiary butanol, 1,1-dimethylpropanol and mixtures thereof. The process provides for obtaining high yields of pure product with the formation of a minimum of side reactions and by-products.
Latest Glyco Chemicals, Inc. Patents:
Type: Grant
Filed: Oct 27, 1977
Date of Patent: Aug 1, 1978
Assignee: Glyco Chemicals, Inc. (Greenwich, CT)
Inventors: Samuel Ellsworth Shull (Cogan Station, PA), John Douglas Freilich (Grand Island, NY)
Application Number: 5/846,019
International Classification: C07D23372;
