Patents Issued in September 18, 1979
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Patent number: 4168277Abstract: Production of tetraethyl ammonium perfluoroalkyl sulphonates (C.sub.2 H.sub.5).sub.4 N.sym.R.sub.F SO.sub.3 .crclbar., wherein R.sub.F represents a perfluorinated alkyl radical with about 4 to 10 carbon atoms, by reacting crude perfluoroalkyl sulphonic acid fluoride, i.e. perfluoroalkyl sulphonic acid fluoride which has not been especially purified, with triethylamine and an ethoxy silane, preferably dimethyl diethoxy silane, methyl triethoxy silane or tetraethoxy silane in an inert solvent at temperatures of about 10.degree. to 60.degree. C., preferably about 20.degree. to 40.degree. C. The process according to the invention is particularly suitable for the production of tetraethyl ammonium perfluorooctane sulphonate.Type: GrantFiled: December 7, 1977Date of Patent: September 18, 1979Assignee: Bayer AktiengesellschaftInventors: Karl-Heinz Mitschke, Hans Niederprum, Johann-Nikolaus Meussdoerffer
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Patent number: 4168278Abstract: One-to-one adducts of primary or secondary amines with .epsilon.-caprolactam are made by heating the reactants in the presence of water at a temperature of between about 170.degree. and 320.degree. C.Type: GrantFiled: July 21, 1978Date of Patent: September 18, 1979Assignee: The Dow Chemical CompanyInventor: Harry A. Smith
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Patent number: 4168279Abstract: Amines of the formula Ar--NH--CH.sub.2 --R, where Ar is unsubstituted or substituted phenyl and R is alkyl of 3 to 6 carbon atoms substituted by hydroxyl groups, are manufactured by catalytic hydrogenation of a salt of an acid of the formula R--COOH in the presence of (a) a compound of the formula Ar--Z, where Z is a nitro or reduced nitro group, and a strong acid or (b) a salt of an amine of the formula Ar--NH.sub.2 and a strong acid, in an organic solvent.Type: GrantFiled: October 6, 1977Date of Patent: September 18, 1979Assignee: BASF AktiengesellschaftInventor: Herbert Scholz
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Patent number: 4168280Abstract: The known compound 2-hydroxy-3-methyl cyclopent-2-ene-1-one, used as a flavor imparting agent and commonly called maple lactone, is synthesized by a modified acyloin condensation of esters of 2-methyl glutaric acid in which oxygen is introduced in a specific manner to the reaction system.Type: GrantFiled: May 19, 1978Date of Patent: September 18, 1979Assignee: El Paso Products CompanyInventor: William D. Nash
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Patent number: 4168281Abstract: Novel cyclopentane derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.4 each represents an alkyl group and R.sup.2 and R.sup.3 each represents a hydrogen atom or alkyl group, are useful as aroma chemicals.Type: GrantFiled: December 27, 1977Date of Patent: September 18, 1979Assignee: Shell Oil CompanyInventors: Robin T. Gray, Aaldert J. De Jong
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Patent number: 4168282Abstract: Mono or dialkyl substituted norbornenes or cyclic norbornene derivatives are prepared by condensing an appropriate olefin or an ethylenically unsaturated alicyclic compound with dicyclopentadiene or cyclopentadiene at an elevated temperature and pressure in the presence of a chlorinated hydrocarbon solvent.Type: GrantFiled: May 15, 1978Date of Patent: September 18, 1979Assignee: The B. F. Goodrich CompanyInventor: Wolfgang Schneider
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Patent number: 4168283Abstract: Viscous copper-containing catalyst waste is split up into solid particles and gaseous dichlorobutene along a steadily curved flow path, the liquid film flowing along an inner tube wall being driven along by the gas flowing at a higher rate in the core.Type: GrantFiled: September 29, 1978Date of Patent: September 18, 1979Assignee: Bayer AktiengesellschaftInventors: Gunter Beilstein, Clemens Casper, Dieter Grenner, Johannes O. Sajben
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Patent number: 4168284Abstract: Preparation of long chain alkane phosphonic acids involves reacting alpha olefin with macroreticular strong acid cation exchange resin to isomerize the olefin, reacting resulting internally unsaturated olefin with dimethylphosphite to produce non-terminally substituted alkanephosphonic acid dimethyl ester, and demethylating with anhydrous hydrogen chloride or hydrogen bromide.Type: GrantFiled: April 19, 1978Date of Patent: September 18, 1979Assignee: The Procter & Gamble CompanyInventor: Daniel S. Connor
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Patent number: 4168285Abstract: A blend of a vinyl chloride polymer, and a crosslinked (meth)acrylate/crosslinked styrene-acrylonitrile/uncrosslinked styrene-acrylonitrile impact modifier is disclosed. The presence of the impact modifier gives the blend improved impact resistance as compared to the vinyl chloride polymer alone. The impact modifier also functions as a heat distortion temperature improver and process aid for the vinyl chloride polymer.Type: GrantFiled: May 22, 1978Date of Patent: September 18, 1979Assignee: Stauffer Chemical CompanyInventor: Michael J. Turczyk
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Patent number: 4168286Abstract: Tetrablock polymers having the configuration B--A.sub.1 --C--A.sub.2 and C--A.sub.1 --B--A.sub.2 and their hydrogenated counterparts are disclosed, wherein B is a low vinyl poly 1,3-butadiene block, A.sub.1 and A.sub.2 can be the same or different polymerized blocks of a monovinylarene monomer having 8-14 carbon atoms per molecule, and C is a block selected from the group consisting of polymerized blocks of a conjugated diene having 4-12 carbon atoms per molecule in which there is on the average at least one side chain branch for every 10 carbon atoms of the polymeric backbone. The hydrogenated tetrablock polymers have the configuration B'--A.sub.1 --C'--A.sub.2 and C'--A.sub.1 --B'--A.sub.2 in which B' is hydrogenated B and C' is hydrogenated block C.Type: GrantFiled: September 23, 1977Date of Patent: September 18, 1979Assignee: Phillips Petroleum Co.Inventor: George A. Moczygemba
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Patent number: 4168287Abstract: Homopolymers, copolymers and terpolymers of a styrene based monomer are prepared by:(1) polymerizing at least one oxidized styrylphosphine monomer selected from the group of:(C.sub.6 H.sub.5).sub.2 P(O)N.dbd.P(C.sub.6 H.sub.5).sub.2 C.sub.6 H.sub.4 CH.dbd.CH.sub.2,(c.sub.6 h.sub.5 o).sub.2 p(o)n.dbd.p(c.sub.6 h.sub.5).sub.2 c.sub.6 h.sub.4 ch.dbd.ch.sub.2,(c.sub.6 h.sub.5).sub.2 c.sub.3 n.sub.3 n.dbd.p(c.sub.6 h.sub.5).sub.2 c.sub.6 h.sub.4 ch.dbd.ch.sub.2 and(C.sub.6 H.sub.5)C.sub.3 N.sub.3 [N.dbd.P(C.sub.6 H.sub.5).sub.2 C.sub.6 H.sub.4 CH.dbd.CH.sub.2 ].sub.2 ; or(2) polymerizing p-diphenylphosphinestyrene and then oxidizing said polymerized p-diphenylphosphinestyrene monomer with an organoazide selected from the group of (C.sub.6 H.sub.5).sub.2 P(O)N.sub.3, (C.sub.6 H.sub.5 O).sub.2 P(O)N.sub.3, (C.sub.6 H.sub.5).sub.2 C.sub.3 N.sub.3 (N.sub.3) and C.sub.6 H.sub.5 C.sub.3 N.sub.3 (N.sub.3).sub.2.Type: GrantFiled: May 19, 1978Date of Patent: September 18, 1979Inventors: James C. Administrator of the National Aeronautics and Space Administration, with respect to an invention of Fletcher, Kazimiera J. L. Paciorek
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Patent number: 4168288Abstract: A combined float bowl carburetor and fuel pump for small engines has a lateral extension on its carburetor body that terminates at a flat exterior surface to which open certain cavities and a passageway leading to the float valve inlet. A block-like pump body having flat inner and outer surfaces overlies said exterior surface and has cavities opening to its inner surface that cooperate with those in the carburetor body. A resilient pump membrane, providing a pump diaphragm and valves, is confined between the pump body and said exterior surface. Two cavities open to the outer face of the pump body, which is overlain by an imperforate resilient membrane to define inlet and outlet surge chambers that are respectively communicated with the pump by way of the inlet and outlet valves. All cavities, inlets and outlets are arranged to ensure maintenance of a consistent head of fuel at every inlet.Type: GrantFiled: June 29, 1978Date of Patent: September 18, 1979Assignee: Briggs & Stratton CorporationInventors: Paul R. Nau, Heinz K. Gund
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Patent number: 4168289Abstract: A baffle device in the fuel bowl of the carburetor of a vehicle maintains the level of fuel in the fuel bowl constant regardless of erratic movement of the vehicle.Type: GrantFiled: December 19, 1977Date of Patent: September 18, 1979Inventor: Oscar P. Saunion
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Patent number: 4168290Abstract: The actual temperature of the extrudate issuing from a long land die extruder is measured and a measurement signal representative thereof is established. The measurement signal is then compared with a setpoint signal representing the desired extrudate temperature to produce a control signal which is responsive to the difference between the measurement signal and the setpoint signal. The cooling fluid being circulated in heat exchange relationship with the extrudate in the long land die is manipulated responsive to the control signal to maintain the actual temperature of the extrudate substantially at the desired extrudate temperature. When the magnitude of the difference between the measurement signal and the setpoint signal exceeds a predetermined value, the rate of heat input to the plasticization section of the extruder and/or the rate of extrusion of the extrudate can be varied to reduce said difference to less than said predetermined value.Type: GrantFiled: February 24, 1978Date of Patent: September 18, 1979Assignee: Phillips Petroleum Co.Inventor: Richard F. Giles
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Patent number: 4168291Abstract: A method of reducing the amount of sulfur trioxide condensation on, and therefore the amount of sulfuric acid corrosion of, metal parts at the cold-end of a combustion system and in contact with combustion gases derived from the combustion of sulfur containing fuel, said method comprising adding to the combustion gases an effective amount for the purpose of an aliphatic, water-soluble alkanolamine additive.Type: GrantFiled: October 30, 1978Date of Patent: September 18, 1979Assignee: Betz Laboratories, Inc.Inventors: Bruce L. Libutti, Francis J. Oschell
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Patent number: 4168292Abstract: Acylated hydroxyalkylaminoalkylamides, the N-alkylated derivatives thereof, and the preparation thereof and uses thereof as corrosion inhibitors.Type: GrantFiled: October 26, 1977Date of Patent: September 18, 1979Assignee: Petrolite CorporationInventors: Derek Redmore, Benjamin T. Outlaw, Delbert C. Scranton, Jr.
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Patent number: 4168293Abstract: Blood oxygenator of the membrane type in which a semi-permeable membrane (by which is meant a membrane that is permeable to gas but not to aqueous liquid) separates the blood from the oxygen but allows diffusion of oxygen into the blood and of carbon dioxide from the blood into the stream of gas; such blood oxygenator being characterized by a plurality of oxygen, water and blood units, each blood unit having a frame which together with semi-permeable membranes forms a blood cavity, the blood entering each such unit from one side, crossing the blood cavity and exiting on the other side, such blood units being isolated from the water units such that leakage of water into the blood units is precluded. Also applicable to oxygenators in which membranes of blood units are permeable to water and small molecules but not to large molecules or particles of the blood.Type: GrantFiled: March 7, 1977Date of Patent: September 18, 1979Inventor: Mogens L. Bramson
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Patent number: 4168294Abstract: Instrument for analyzing, by means of photometric measurements, precisely metered quantities of samples, such as serum, plasma, cerebro-spinal liquid and the like, homogeneously diluted in selectively prechosen reagents.Type: GrantFiled: May 16, 1977Date of Patent: September 18, 1979Inventors: Claudio Calzi, Alberto Musetti, Adriano Trisciani
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Patent number: 4168295Abstract: An apparatus for enhancing chemical reactions in a constantly flowing stream of liquid character fortified with oxidizing agents, such as air or oxygen or other chemical agents, makes use of an inner resonant tube concentrically mounted within an outer resonant tube with the walls of the tubes spaced from each other forming an annular passageway for the flow of liquid from one end of the passageway to the other. One or more sets of radially spaced ultrasonic transducers are located on the outside wall of the outer resonant tube thereby to create an ultrasonic cavitation condition in the liquid as it flows through the annular passageway.Type: GrantFiled: September 27, 1977Date of Patent: September 18, 1979Assignee: Vernon D. BeehlerInventor: Harold T. Sawyer
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Patent number: 4168296Abstract: A process for recovering tungsten from tungsten bearing ores comprises producing a concentrate from the ore and leaching the concentrate at atmospheric pressure in a strong mineral acid solution, for example, a solution of sulfuric acid, hydrochloric acid or nitric acid within a temperature range of from 40.degree. to 90 Centigrade for from one to four hours in the presence of an inorganic complexing agent, and adding an ammonium salt compound for precipitating the tungsten. The precipitate is then dissolved in Ammonium Hydroxide and the tungsten recovered as Ammonium Paratungstate.Type: GrantFiled: February 17, 1978Date of Patent: September 18, 1979Inventor: Adolph Q. Lundquist
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Patent number: 4168297Abstract: An improved process is described for producing titanium dioxide from ilmenite-type ore. The ore is digested with aqueous hydrogen fluoride, the resulting liquid mixture treated with a water-soluble oxidizing agent, and the ferric iron impurities, in the resulting digestion solution, at a pH between about 1.0 and 6.0, are extracted out with a mono-or dialkyl, or mono- or di-(alkylphenyl) orthophosphoric acid, such as di-(2-ethylhexyl) orthophosphoric acid. The remaining solution is treated with ammonium hydroxide to precipitate hydrated titanium dioxide which is then calcined to form pigmentary titanium dioxide. Alkali metal and ammonium salts of the organophosphoric acid are also useful in the process.Type: GrantFiled: December 8, 1978Date of Patent: September 18, 1979Assignee: Allied Chemical CorporationInventors: Krishnamurthy Nagasubramanian, Kang-Jen Liu
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Patent number: 4168298Abstract: A process for forming polytetrafluoroethylene yarn by(1) forming an oriented polytetrafluoroethylene film by drawing a sintered sheet from about 5 to 30 times its original length at an elevated temperature; and(2) passing the oriented film through fibrillating means such as a high turbulent air velocity jet to form a yarn of entangled irregular shaped non-uniform staple fibrils.The yarn and woven, non-woven and knitted fabrics prepared from this yarn also are part of the invention.Type: GrantFiled: August 25, 1977Date of Patent: September 18, 1979Assignee: E. I. Du Pont de Nemours and CompanyInventor: Emerson B. Fitzgerald
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Patent number: 4168299Abstract: A method for hydrolyzing urea in aqueous solutions such as waste-water streams which comprises heating the aqueous solution containing urea in the presence of a catalytic amount of vanadium pentoxide for sufficient time and at sufficient temperatures to effect hydrolysis of substantially all of the urea to ammonia and carbon dioxide.Type: GrantFiled: March 20, 1978Date of Patent: September 18, 1979Assignee: Olin CorporationInventor: Lorenz P. Schell
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Patent number: 4168300Abstract: Hepatitis virus is removed from a biological material contaminated with the virus by contact with a preparation. The preparation may be agarose gel or beaded polyacrylamide plastic coupled with a variety of hydrophobic ligands.Type: GrantFiled: July 6, 1976Date of Patent: September 18, 1979Assignee: AB KabiInventors: Lars-Olov Andersson, Hakan G. Borg, Gudrun M. Einarsson
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Patent number: 4168301Abstract: The invention relates to a dentifrice which contains at least 40% by weight of abrasive agent of which at least 30% by weight of the dentifrice is alpha-alumina trihydrate having a particle size such that at least about 20%, and preferably at least about 25%, by weight of the particles have a size greater than 20 microns. The dentifrice when in the form of a toothpaste preferably contains as sole abrasive agent 45% to 60% by weight of particles of alpha-alumina trihydrate of gaussian distribution and weight median diameter of about 14 to about 25 microns.Type: GrantFiled: July 19, 1974Date of Patent: September 18, 1979Assignee: Lever Brothers CompanyInventors: Brinley R. Pugh, Charles A. Watson
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Patent number: 4168302Abstract: Cationic surfactants are provided which are useful alone as the active compounds in creme hair rinse and in conjunction with anionic surfactants in other hair conditioning preparations based on anionic-cationic surfactant systems. Such cationic surfactants are non-irritating to the eyes and are compatible with the other conventional ingredients used in hair conditioning preparations. These cationic surfactants are also compatible with anionic surfactants without objectionably reducing or otherwise interfering with the foam normally formed by the anionic surfactants in hair conditioning preparations. Useful cationic surfactants of the present invention have the following general formula: ##STR1## wherein ##STR2## is a fatty acid group containing from 6 to 20 carbon atoms, and n.sub.1, n.sub.2 and n.sub.3 are the same or different integers not exceeding 3. Two cationic surfactants of the invention presently preferred are: isostearylamidopropylmorpholine lactate and stearylamidopropylmorpholine lactate.Type: GrantFiled: March 30, 1978Date of Patent: September 18, 1979Assignee: The Richardson CompanyInventor: Thomas G. Schoenberg
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Patent number: 4168303Abstract: Freeze-drying of an aqueous solution of human native gamma globulin having an anticomplementary activity of 20 (C'H50) or less in the presence of 0.06 to 0.26 part by weight of a neutral inorganic salt for 1 part by weight of the gamma globulin gives an immunoactive lyophilized native gamma globulin preparation which has undergone neither increase in anticomplementary activity nor deterioration in antibody activity during the freeze-drying and is safe for use in intravenous administration.Type: GrantFiled: June 7, 1978Date of Patent: September 18, 1979Assignee: The Green Cross CorporationInventors: Masayuki Nishida, Sadao Yabushita, Shigeru Fujita, Toshiyuki Saki
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Patent number: 4168304Abstract: 4-Substituted-pyrimidin-6-yl (thiono)-phosphoric (phosphonic) acid esters or ester-amides of the formula ##STR1## in which R represents hydrogen, alkyl, alkoxy, alkylthio or alkylamino,R.sup.1 represents halogen, alkoxy, alkylthio or alkylamino,R.sup.2 represents alkyl, alkoxy, alkylamino or phenyl,R.sup.3 represents alkyl andX and Y, which may be identical or different, represent oxygen or sulphur,Which possess arthropodicidal and nematicidal properties.Type: GrantFiled: January 12, 1978Date of Patent: September 18, 1979Assignee: Bayer AktiengesellschaftInventors: Fritz Maurer, Hans-Jochem Riebel, Rolf Schroder, Ingeborg Hammann, Wolfgang Behrenz, Bernhard Homeyer, Wilhelm Stendel
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Patent number: 4168305Abstract: S-Alkyl-N-carbonyl-alkanedithiophosphonic acid ester-amides of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is alkyl, andR.sup.3 is alkoxy, alkoxyalkoxy, alkylthio, alkenyloxy, alkynyloxy, aralkoxy, aryloxy, amino, monoalkylamino, dialkylamino, monoalkenylamino or arylamino,Which possess arthropodicidal and nematicidal properties.Type: GrantFiled: January 5, 1978Date of Patent: September 18, 1979Assignee: Bayer AktiengesellschaftInventors: Fritz Maurer, Hans-Jochem Riebel, Rolf Schroder, Ingeborg Hammann, Bernhard Homeyer, Wolfgang Behrenz
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Patent number: 4168306Abstract: 17.alpha.-Acetylenic-.DELTA..sup.4 -androstenes of the formula ##STR1## wherein R is saturated or unsaturated alkyl of 1 to 12 carbon atoms and the dotted line indicates the optional presence of a double bond in the 1(2) position of the A ring with the proviso that R is not methyl when the A ring has only one double bond having a remarkable local anti-inflammatory activity and a process for their preparation.Type: GrantFiled: February 17, 1978Date of Patent: September 18, 1979Assignee: Roussel UclafInventors: Jean G. Teutsch, Roger Deraedt
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Patent number: 4168307Abstract: N.sup.2 -naphthalenesulfonyl-L-arginine amides having the formula ##STR1## or the acid addition salts thereof with a pharmaceutically acceptable acid wherein R.sub.1 is alkenyl of not more than 10 carbon atoms, or substituted alkyl containing not more than 20 carbon atoms wherein said substituent is a member selected from the class consisting of alkoxy, alkoxycarbonyl, arylcarbamoyl acyl, acyloxy, N,N-polymethylenecarbamoyl and carboxy, and R.sub.2 is aryl, cycloalkyl, aralkyl or cycloalkylalkyl, respectively containing not more than 15 carbon atoms and R' is 1-naphthyl substituted with a member selected from the class consisting of 2-dialkylamino, 3-dialkylamino, 4-dialkylamino, 6-dialkylamino, 7-dialkylamino, 8-dialkylamino, respectively containing not more than 20 carbon atoms, and 5-dialkylamino containing 3-20 carbon atoms; or 2-naphthyl substituted with dialkylamino containing not more than 20 carbon atoms.Type: GrantFiled: October 21, 1977Date of Patent: September 18, 1979Assignees: Mitsubishi Chemical Industries Limited, Shosuke OkamotoInventors: Shosuke Okamoto, Ryoji Kikumoto, Yoshikuno Tamao, Kazuo Ohkubo, Shinji Tonomura
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Patent number: 4168308Abstract: According to the invention, the parenteral administration of water-insoluble pharmacologically active agents is enhanced wherein the agents are administered in the lipoid phase of a carrier emulsion comprising a microemulsion of a finely dispersed lipoid in an aqueous phase. The lipoid preferably has a mean particle size below 1 micron. This makes it possible to administer water-insoluble agents in high concentrations, and thus a lower dose, whereby a rapid onset of the pharmacological effect is accompanied by a markedly reduced incidence of injury to body tissues.Type: GrantFiled: November 23, 1977Date of Patent: September 18, 1979Assignee: Apoteksvarucentralen Vitrum ABInventors: Karl A. J. Wretlind, Stellan Ljungberg, Ivan Hakansson, Bengt M. Ajaxon
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Patent number: 4168309Abstract: Antibiotic compounds of the general formula ##STR1## [wherein R is a phenyl, thienyl or furyl group; R.sup.a and R.sup.b which may be the same or different, are each selected from hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.3-7 cycloalkyl, phenyl, naphthyl, thienyl, furyl, carboxy, C.sub.2-5 alkoxycarbonyl and cyano, or R.sup.a and R.sup.b together with the carbon atom to which they are attached form a C.sub.3-7 cycloalkylidene or cycloalkenylidene group; m or n are each 0 or 1 such that the sum of m and n is 0 or 1; and R.sup.Type: GrantFiled: September 30, 1977Date of Patent: September 18, 1979Assignee: Glaxo Laboratories LimitedInventor: Barry E. Ayres
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Patent number: 4168310Abstract: Novel 1,3,4-benzotriazepine-2-thiones and related tricyclic derivatives having central nervous system activity and a method for use for treating the symptoms of central nervous system depression and anxiety.Type: GrantFiled: February 13, 1978Date of Patent: September 18, 1979Assignee: The Dow Chemical CompanyInventors: Donald L. Trepanier, Thomas C. Britton
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Patent number: 4168311Abstract: Hydroxypyridine carbamates of the formula ##STR1## wherein R.sub.1 to R.sub.5 as defined below are valuable insecticides and particularly aphicides andCompounds of the formula ##STR2## wherein one of R'.sub.1 and/or R'.sub.3 are substituted carbamoyl and the other is preferably hydrogen or methyl, R'.sub.2 is a variety of substituents among which is hydrogen and acetyl, and R'.sub.3 and R'.sub.4 preferably form together a saturated or unsaturated C.sub.4 -chain which may be substituted, are valuable aphicides.Type: GrantFiled: June 20, 1977Date of Patent: September 18, 1979Assignee: Hoechst AktiengesellschaftInventors: Adolf Studeneer, Gerhard Salbeck, Ludwig Emmel, Werner Knauf
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Patent number: 4168312Abstract: New quinolone derivatives of the Formula I ##STR1## wherein R.sup.1 and R.sup.2 are each H, F, Cl, Br, CF.sub.3 or CH.sub.3 O or a physiologically acceptable acid addition salt thereof possess pharmacological properties including thrombocyte aggregation inhibiting action.Type: GrantFiled: November 8, 1977Date of Patent: September 18, 1979Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Erich Schacht, Hans Dahm, Reinhard Lissner
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Patent number: 4168313Abstract: A new phthalidylic eater of 2-(3'trifluoromethyl-anilino)-pyridine-3-carboxylic acid is prepared by reacting 2-(3'-trifluoromethylanilino)-pyridine-3-carboxylic acid with 3-bromophthalide and an organic base in a reaction medium comprising a solvent selected from the group consisting of acetone, dimethylformamide, dimethylacetamide and acetonitrile. The product has an antiinflammatory activity without the ulcerogenic effect that is characteristic of the corresponding acid.Type: GrantFiled: February 21, 1978Date of Patent: September 18, 1979Inventor: Sebastian Bago
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Patent number: 4168314Abstract: Disclosed is 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid: ##STR1## Such compound and its pharmaceutically acceptable salt and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.Type: GrantFiled: November 17, 1977Date of Patent: September 18, 1979Assignee: Merck & Co., Inc.Inventors: Burton G. Christensen, Frank P. DiNinno
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Patent number: 4168315Abstract: Novel compounds of Formula I: ##STR1## in association with a pharmaceutical carrier. The compositions are useful in vitro and in vivo for reduction of platelet adhesiveness and inhibition of platelet aggregation and preventing or treating disease conditions resulting from increased platelet adhesiveness or platelet aggregation.Type: GrantFiled: September 28, 1977Date of Patent: September 18, 1979Assignee: The Upjohn CompanyInventors: Ronald H. Rynbrandt, Edward E. Nishizawa
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Patent number: 4168316Abstract: By isolation and purification from the urine of patients treated with niridazole there is obtained substantially pure 1-(thiocarbamoyl)-2-imidazolidinone which exhibits marked immunosuppressive activity.Type: GrantFiled: March 6, 1978Date of Patent: September 18, 1979Assignees: Northwestern University, Case Western Reserve UniversityInventors: Leslie T. Webster, Jr., Kenneth S. Warren
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Patent number: 4168317Abstract: New aminopropanol derivatives of 4-hydroxy-1,2-benzisothiazole and their addition salts with acids, their preparation, and pharmaceutical formulations which contain the said compounds and may be used for the treatment and prophylaxis of cardiac and circulatory disorders.Type: GrantFiled: January 30, 1978Date of Patent: September 18, 1979Assignee: BASF AktiengesellschaftInventors: Fritz-Frieder Frickel, Helmut Hagen, Ulrich Ohnsorge, Albrecht Franke, Dieter Lenke, Josef Gries, Hans D. Lehmann
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Patent number: 4168318Abstract: New 1-(2',4',6'-trihydroxyphenyl)-propanedione-(1,2)-compounds of the formula ##STR1## wherein R is ##STR2## and their acid addition salts are particularly effective in the treatment of liver diseases.Type: GrantFiled: May 2, 1977Date of Patent: September 18, 1979Assignee: Dr. Madaus & Co.Inventors: Rolf Madaus, Gunter Halbach, Wilfried Trost
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Patent number: 4168319Abstract: N-alkynyl-2-(substituted phenoxy) butyramide compounds having the formula ##STR1## in which X is bromine or methyl and R is hydrogen or methyl, and their use as mildewicides for controlling the growth of mildew are disclosed.Type: GrantFiled: October 26, 1977Date of Patent: September 18, 1979Assignee: Stauffer Chemical CompanyInventors: Francis H. Walker, Don R. Baker
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Patent number: 4168320Abstract: Novel ethynylbenzene compounds and derivaties are described. Their use in the treatment of inflammation is also disclosed.Type: GrantFiled: December 6, 1977Date of Patent: September 18, 1979Assignee: William H. Rorer, Inc.Inventor: Julius Diamond
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Patent number: 4168321Abstract: A press-formed tablet-shape sweet colored only on its outer surfaces by selectively applying a coloring agent after the sweet has been press-formed. The surface to be colored may be land portions or lower portions.Type: GrantFiled: April 26, 1978Date of Patent: September 18, 1979Assignee: Hamada Foods Chemical Industries Co., Ltd.Inventor: Toshiro Okamoto
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Patent number: 4168322Abstract: A protein food product is described, together with a process for making it. Whey protein derived from milk is adjusted to a pH of 6 to 9 and coagulated by heat, thereby giving a firm, non-brittle material which is useful as a protein food in its own right, or as a matrix for composite products, or in the manufacture of pieces resembling meat offals such as kidney, to improve the texture of meat-containing mixes, for example of sausage type, and for other food products, all of which are useful as protein foods for animals and also for human beings.Type: GrantFiled: August 17, 1977Date of Patent: September 18, 1979Assignee: Mars LimitedInventors: Keith Buckley, Philip J. Lowe
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Patent number: 4168323Abstract: A food additive composition admixed with fish mince consisting of a hydrophilic powdery colloidal solid having a particle size smaller than 20 mesh and comprising 60 to 99% of a sugar alcohol or a sugar, 30 to 0.5% of a food-grade surface-active agent and 30 to 0% of an edible oil or fat. The food additive can be prepared by adding a food-grade surface-active agent and an oil or fat to a melt or aqueous solution of a sugar alcohol or a sugar to dissolve them or disperse them in a fine particlar form, optionally adding a sugar alcohol or a sugar as a seed crystal, solidifying the solution or dispersion to form a colloidal solid, stabilizing the colloidal solid by crystallization, optionally drying the stablized solid, and pulverizing it to a particle size smaller than 20 mesh.Type: GrantFiled: May 27, 1977Date of Patent: September 18, 1979Assignee: Kabushiki Kaisha Veno Seiyako Oyo KenkyujoInventors: Shigeo Inamine, Toshio Matsuda, Takeo Shimomura
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Patent number: 4168324Abstract: A method of producing coffee low in undesired stimulants by removing coffee wax from unroasted coffee by the use of a supercritical fluid and absorbing the coffee wax in an absorbent precharged with pure caffeine.Type: GrantFiled: February 25, 1977Date of Patent: September 18, 1979Assignee: HAG AktiengesellschaftInventors: Ludwig Roselius, Hans-Albert Kurzhals, Klaus F. Sylla, Peter Hubert
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Patent number: 4168325Abstract: The invention provides a process for producing pimiento paste for use in stuffing olives. The process involves sorting and chopping pimiento, preserving it in brine, washing the preserved pimiento to desalt it, mixing the desalted pimiento with sodium alginate, guar gum, potassium sorbate, and water, and homogenizing the resulting mass until a gelatinous mixture is obtained from which any entrapped air is thereafter removed. The resulting uniform, semi-liquid paste is spread on a conveyor belt where it gradually thickens, then is submerged in a calcium chloride bath to precipitate the alginic acid, after which the paste becomes hardened, separates from the conveyor belt, and is removed.Type: GrantFiled: April 8, 1977Date of Patent: September 18, 1979Assignee: Medina Garvey Aceitunas, S.A.Inventors: Jose M. Gonzalez, Cristino L. Cortes
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Patent number: 4168326Abstract: Novel prosthesis parts of improved properties are obtained by providing a material as used for prostheses with an enamel or enamel-like coating and incorporating in said enamel layer, while in a viscous state, a bioactive material. Such prosthesis parts have a satisfactory adhesive strength and coefficient of expansion, are substantially free of pores, are highly corrosion resistant, and readily grow intimately and firmly together with the bone tissue without the use of bone cement.Type: GrantFiled: October 18, 1976Date of Patent: September 18, 1979Assignee: Ernst Leitz Wetzlar, GmbHInventors: Heinz Broemer, Werner Adam, Friedhelm Hedrich