Abstract: Ceramic oxide powders and methods for their preparation are revealed. Ceramic oxide powders are obtained using a flame process whereby one or more precursors of ceramic oxides are introduced into a counterflow diffusion flame burner wherein the precursors are converted into ceramic oxide powders. The nature of the ceramic oxide powder produced is determined by process conditions. The morphology, particle size, and crystalline form of the ceramic oxide powders may be varied by the temperature of the flame, the precursor concentration ratio, the gas stream and the gas velocity.

Abstract: Spindle-shaped goethite particles are produced by oxidizing a ferrous carbonate intermediate in the presence of a growth modifier, or alternatively by changing the flowrate of oxidizing gas during oxidation. The goethite particles thus produced have a narrow size distribution, high aspect ratio and are substantially dendrite-free. These properties make the inventive goethite particles suitable for use in preparation of high density magnetic recording media.

Abstract: Hydrogen is produced from a hydrocarbon by contacting the hydrocarbon with fine particles of a carbonaceous material having an external surface area of at least 1 m.sup.2 /g at a temperature sufficient to pyrolyze the hydrocarbon.

Abstract: This invention relates to dichelants, in particular compounds having two macrocyclic chelant groups linked by a bridge containing an ester or amide bond, especially compounds of formula Vb ##STR1## (wherein each X which may be the same or different is NZ, O or S, at least two Xs being NZ;each Z is a group R.sup.1 or a group CR.sup.1.sub.2 Y, at least one Z, and preferably 2 or 3 Zs, on each macrocyclic ring being a group CR.sup.1.sub.2 Y;each Y is a group CO.sub.2 H, PO.sub.3 H, SO.sub.3 H, CONR.sup.1.sub.2, CON(OR.sup.1)R.sup.1, CNS or CONR.sup.1 NR.sup.1.sub.2, preferably COOH;m is 0 or 1 or 2, preferably 1; each n is 2 or 3, preferably 2; q is 1 or 2, preferably 1;each R.sup.

Abstract: Somatostatin peptides bearing a chelating group selected from a bifunctional N.sub.4 -chelating group particularly suitable for Tc, Rh, Cu, Co or Re-labelling, and a bifunctional polyamino-polycarboxylic acid chelating group are complexed with a .alpha.-, .beta.-, .gamma.- or positron-emitting nuclide or a nuclide with Auger-e.sup.- -cascades and are useful as radiopharmaceuticals.

Abstract: Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.

Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.

Abstract: The invention relates to a cosmetic and/or dermatological composition comprising at least one superoxide dismutase and at least one porphyrin. In a composition of this kind the porphyrin synergically reinforces the anti-free radical action of the superoxide dismutase.The composition is used in particular to combat cell ageing and/or for the protection of the skin, hair and/or mucosae against the harmful and/or unaesthetic effects caused by oxygen-containing free radicals.

Abstract: The present invention provides an improved activator and method of utilizing same in applying durable protective coating on natural or artificial nails. The activator utilized for curing a gel component has a viscosity of approximately 10 to 5000 centipoise. The activator preferably includes a solvent, a polymerization initiator, and a viscosity modifying agent. The present invention also provides a method for applying a protective coating on a nail surface. The method includes the steps of applying an effective amount of adhesive on the nail surface, applying an effective amount of an activator having a viscosity of approximately 10 to 5000 centipoise on the nail surface, blending the adhesive and the activator together on the nail surface to form a blended mixture, and brushing the blended mixture over the nail surface.

Abstract: An oil-based solid cosmetic composition comprising one or more polyoxyalkylene modified silicones and one or more conventional cosmetically acceptable oils, pigments, paints or a mixture thereof, is provided to give a cosmetic having excellent feel during use and prolonged beautiful make-up appearance.

Abstract: This invention provides a deodorant cosmetic stick product which has a translucent or transparent light transmitting appearance. The cosmetic stick has a content of ingredients such as sodium bicarbonate, propylene glycol, sodium stearate, dimethicone copolyol, Pentadoxynol-200, and water. An invention deodorant cosmetic stick has excellent esthetics when applied underarm, such as smoothness and a comfortable dry feel, and without a visually perceptible residue.

Abstract: This invention provides a deodorant cosmetic stick product which has a translucent or transparent light transmitting appearance. The cosmetic stick has a content of ingredients such as sodium bicarbonate, propylene glycol, sodium stearate, Steareth-100, Pentadoxynol-200, and water. An invention deodorant cosmetic stick has excellent esthetics when applied underarm, such as smoothness and a comfortable dry feel, and without a visually perceptible residue.

Abstract: This invention provides a deodorant cosmetic stick product which has a translucent or transparent light transmitting appearance. The cosmetic stick has a content of ingredients such as sodium bicarbonate, propylene glycol, sodium stearate, Poloxomer 407, Pentadoxynol-200, and water. An invention deodorant cosmetic stick has excellent esthetics when applied underarm, such as smoothness and a comfortable dry feel, and without a visually perceptible residue.

Abstract: This invention provides a deodorant cosmetic stick product which has a translucent or transparent light transmitting appearance. The cosmetic stick has a content of ingredients such as propylene glycol, sodium stearate, dimethicone copolyol, Triclosan, Pentadoxynol-200, and water. An invention deodorant cosmetic stick has excellent esthetics when applied underarm, such as smoothness and a comfortable dry feel, and without a visually perceptible residue.

Abstract: An antiperspirant gel stick composition incorporating a gelling agent, including a primary gellant selected from the group consisting of 12-hydroxystearic acid, esters of 12-hydroxystearic acid, amides of 12-hydroxystearic acid, and mixtures thereof and a secondary gellant selected from the group consisting of n-acyl amino acid amide derivatives. The antiperspirant gel stick compositions further incorporate a liquid base material including a non-polar, volatile oil and a relatively polar, non-volatile co-solvent. The combination of the gelling agent and the co-solvent permit the utilization of relatively high levels of a non-polar volatile oils which provide a dry feel.

Abstract: Dermatological/cosmetic compositions for reducing or decelerating human hair loss comprise an effective hair loss-reducing amount of combinatory immixture of (a) at least one antifungal agent and (b) at least one halogenated antibacterial agent other than a macrolide or pyranoside, characteristically formulated in a topically physiologically acceptable medium therefor.

Abstract: The invention is concerned with silicone-based skin care products which are applied to the skin as aerosols and form a clear gel on the skin. The skin care products comprise 20-70% w/w of a silicone based water-in-oil microemulsion and 30-80% w/w of a volatile diluent. Preferably the microemulsion has a viscosity of between 1000 and 10,000 mPas.

Abstract: The present invention relates to the identification of promoters of myelopoietic blood cell production. In particular, an agent has been discovered that enhances myelopoietic colony stimulating factor activity. The agent comprises cytokines that are also capable of binding to heparin, and inducing localized inflammation characterized by polymorphonuclear cell infiltration when administered subcutaneously. Particular agents comprise the inflammatory cytokines MIP-1 and MIP-2. Diagnostic and therapeutic utilities are proposed, and pharmaceutical compositions are likewise set forth.

Abstract: Methods of genetically modifying donor cells by gene transfer for grafting into the central nervous system to treat defective, diseased or damaged cells are disclosed. The modified donor cells produce functional molecules that effect the recovery or improved function of cells in the CNS. Methods and vectors for carrying out gene transfer and grafting are described.

Abstract: A cosmetic composition containing triglyceride oleate and yeast extract and further, if desired, an L-cysteine hydrochloride as components for proliferating indigenous bacteria on the skin.

Abstract: Immunoconjugates for the selective delivery of a cytokine to a target cell are disclosed. The fusion proteins are comprised of an immunoglobulin heavy chain having a specificity for the target cell, such as a cancer or virus-infected cell, and a cytokine, such as lymphotoxin, tumor necrosis factor alpha, interleukin-2, or granulocyte-macrophage colony stimulating factor, joined via its amino terminal amino acid to the carboxy-terminus of the immunoglobulin. Nucleic acid sequences encoding these fusion proteins and methods of their preparation by genetic engineering techniques are also disclosed.

Abstract: The present invention relates to purified and isolated citrus blight, antigens and antibodies thereto leaf proteins which are specific indicators of the presence of citrus blight. The isolated and purified citrus blight leaf proteins are extracted from citrus blighted leaves and have a molecular weight of about 10,000 to about 30,00 daltons.

Abstract: The present invention provides a liposome comprising an effective immunoadjuvant amount of a lymphokine such as IL-2. Also provided is an effective antineoplastic amount of IL-2 liposomes in combination with adoptively transferred cells stimulated with anti-CD3 monoclonal antibody plus IL-2.

Abstract: There is provided a recombinant Marek's disease virus comprising the genomic DNA of an attenuated Marek's disease virus and a foreign gene from another source. The present recombinant virus can advantageously be used as an active ingredient for a multifunctional live vaccine, exhibiting not only the antigenicity and immunogenicity of the Marek's disease virus but also the properties ascribed to the foreign gene. Since the suitable host cell for the recombinant virus of the present invention is an avian cell which is available in a large quantity and not expensive, the recombinant virus of the present invention can be produced efficiently at low cost on a commercial scale.

Abstract: Methods and kits for identifying antigens from a pathogen. The antigens identified are preferably those that provide protection for an animal against the pathogen. The steps of the method include providing a sample of the pathogen, isolating the protective antigen from the sample of antigen with an antibody probe. The antibody probe is produced by obtaining a biological sample containing antibody producing cells from an immune animal infected with or challenged by the pathogen or pathogen extract, and obtaining the antibodies from these cells by culturing the cells. These methods and kits are useful for preparing antigens to be used as vaccines, in diagnostic kits, and to prepare polyclonal or monoclonal antibodies.

Abstract: Oil based vaccines often cause serious local side effects at the site of administration and/or have a high viscosity which make said vaccines difficult to handle. Vaccines comprising as an adjuvant a stable emulsion of tocols in water do not display these undesired effects and induce good immune responses.

Abstract: In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.

Abstract: Some otherwise desirable oil compositions derived from natural sources are characterized by an unpleasant odor. Fractions or combinations of such oils may also be so characterized. Stable, deodorized oils may be prepared by adding an amount of a deodorizing agent effective to substantially reduce the odor of the derived oil composition, fraction or combination thereof to that oil composition, fraction or combination. The pharmaceutical topical compositions of the present invention contain these stable, deodorized oil compositions and exhibit enhanced penetration properties and achieve enhanced patient response. The improved pharmaceutical compositions of the present invention may be used to manage pain and/or to treat the underlying ailments. Methods of making such topical pharmaceutical compositions are also discussed.

Abstract: A skin-moisture-regulating composition for cosmetic or dermatological preparations, the composition containing succinic acid derivatives corresponding to formula I:R.sup.1 O(C.sub.n H.sub.2n O).sub.x CO--CHR.sup.2 --CHR.sup.3 --CO(OC.sub.n H.sub.2n O).sub.y OR.sup.4 (I)wherein R.sup.1 is an alkyl, alkenyl, mono-or dihydroxyalkyl or hydroxyalkenyl group containing 6 to 22 carbon atoms, one of R.sup.2 and R.sup.3 is hydrogen and the other is an alkyl or alkenyl group containing 12 to 22 carbon atoms, n=2 or 3, x and y are average degrees of alkoxylation and have values of 0 to 20 and 1 to 20, respectively, and R.sup.4 is hydrogen or a group R.sup.1 O--(C.sub.n H.sub.2n O).sub.x --CO--CHR.sup.2 --CHR.sup.3 --CO--, or an alkyl, alkenyl, mono- or dihydroxyalkyl or hydroxyalkenyl group containing 6 to 22 carbon atoms.

Abstract: The present invention relates to a cosmetic or pharmaceutical composition comprising an aqueous dispersion of polymers, in particular as film-forming agent. The said aqueous dispersions are obtained by radical polymerization of radical monomer, within and/or partially at the surface, of preexisting particles of at least one polymer chosen from the group consisting of polyurethanes and/or polyureas.

Abstract: Process for attracting male olive pests, particularly male Prays oleae or Palpita unionalis, wherein an appropriate amount of the following composition is used, preferably in an amount of about 10 to about 40 mg:an inclusion complex of a cyclodextrin and of at least one of the following compounds:a linear chain of 10 to 20 carbon atoms, substituted or not, saturated or unsaturated, under the acetate or aldehyde or alcohol form, provided that such chain is different from ethyl dodecanoate,and more particularly:Z-7-tetradecenal,E-11-hexadecenal,E-11-hexadecenyl acetate.The distribution of this sex pheromone confuses the male olive pests as to the whereabouts of the females.

Abstract: The present invention relates to novel dry-blended extrudable pesticidal resin composition, extruded pesticidal resin compositions and pelletized pesticidal resin compositions comprising, as the active ingredient, O,O-diethyl S-[[1,1-dimethylethyl)thio]methyl]phosphorodithioate, O,O-diethyl S-(ethylthiomethyl)phosphorodithioate or a pesticidal chemical wherein said technical grade of said pesticidal chemical has a dermal and/or oral LD50, as measured on rats or rabbits of less than 50 mg/kg. The novel compositions of the present invention are characterized by markedly reduced mammalian toxicity and increased pesticide stability and are essentially free of dust. Further, the present invention also relates to a process for preparing the present safened pesticidal resin compositions.

Abstract: The present invention relates to novel dry-blended extrudable pesticidal resin composition, extruded pesticidal resin compositions and pelletized pesticidal resin compositions comprising, as the active ingredient, O,O-diethyl S-[[1,1-dimethylethyl)thio]-methyl]phosphorodithioate, O,O-diethyl S-(ethylthiomethyl)phosphorodithioate or a pesticidal chemical wherein said technical grade of said pesticidal chemical has a dermal and/or oral LD50, as measured on rats or rabbits of less than 50 mg/kg. The novel compositions of the present invention are characterized by markedly reduced mammalian toxicity and increased pesticide stability and are essentially free of dust. Further, the present invention also relates to a process for preparing the present safened pesticidal resin compositions.

Abstract: The invention relates to biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500 .mu., characterised by containing an ordered series of holes of a constant size between 10 and 1000 .mu., separated from each other by a constant distance of between 50 and 1000 .mu., and obtained by perforation by mechanical, thermal laser or ultraviolet radiation means, they being suitable for use as a support for the in vitro growth of epithelial cells, the invention also relating to the artificial skin obtained thereby and its use in grafts.

Abstract: This invention provides a percutaneous absorption preparation for use in the percutaneous administration of drugs for percutaneous absorption into the living body for the purpose of preventing or treating various diseases, which has excellent adhesion to the skin and does not cause pain and damage to corneum when peeled off. Its pressure-sensitive adhesive layer contains an acrylic copolymer comprising a (meth)acrylic acid alkyl ester and a functional monomer as essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms and a drug for percutaneous absorption, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of the drug from the preparation is improved and the area of the preparation can be miniaturized.

Abstract: Moisturizing composition for the simultaneous treatment of the surface layers and deep layers of the skin, and use thereof. The composition of the invention comprises a first dispersion of lipid vesicles which are capable of penetrating into the deep layers of the skin and which contain at least one active agent selected from the group consisting of polyols, sugars, proteins, vitamins and the derivatives thereof, ceramides, essential fatty acids, and sterols, for treating these deep layers, and a second dispersion of lipid vesicles which are capable of penetrating into the surface layers of the skin and which contain at least one active agent selected from the group consisting of polyols, nitrogen-containing carboxylic acid derivatives, keratolytic agents, inorganic salts and lipoamino acids, for treating these surface layers.

Abstract: Disclosed is a method of inhibiting hepatitis B infection by administering a therapeutically effective amount of a compound having the formula (Formula 1): ##STR1## wherein R1 is selected from the group consisting of H, lower alkanoyl, lower arylalkylacyl, arylacyl, and C-1-linked saccharide, and R2 is separately selected from the group consisting of H, lower alkyl, lower arylalkyl, aryl, and C-1-linked saccharide. The compounds may also be used to treat other conditions, such as inflammatory bowel disease, autoimmune diseases, transplant rejection, septic shock, and for protection against irradiation damage. Novel celastrol derivatives are also disclosed.

Abstract: The invention concerns tablets with improved bioavailability of the active substance dichloromethylenediphosphonic acid or of a physiologically tolerated salt thereof and with a content of microcrystalline cellulose as a pharmaceutical auxiliary substance, pharmaceutical packs containing these tablets, the use of the active substance dichloromethylenediphosphonic acid together with microcrystalline cellulose for the production of a tablet with improved bioavailability and the process for producing the tablet.

Abstract: A pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times produced via the steps of: a) preparing a tablet consisting of three superposed layers, the upper layer containing an active ingredient, the intermediate layer not containing any active ingredient and forming a barrier-type layer, and the lower layer containing an active ingredient, said upper layer presenting a raised top, b) coating the tablet entirely with an impermeable polymeric film, and c) removing said raised top and thus allowing contact of the abraded upper layer surface with the environment.

Abstract: A drug delivery device is disclosed for delivering a drug to the intestine and the colon. The device comprises external means for delaying the delivery of drug in the stomach, and hydrophobic means for preventing the passage of fluid through the delay means.

Abstract: Novel retinoic acid-containing topical compositions in the form of creams, lotions, gels, and the like, are disclosed. These compositions contain a urethane compound having a molecular weight of up to about 60,000, prepared by reacting approximately two moles of a hydroxy-terminated linear alkylene or polyalkylene glycol with approximately one mole of a monomeric organic diisocyanate. The presence of the urethane compound leads to decreased percutaneous transmission of the retinoic acid, resulting in reduced skin irritation but undiminished therapeutic effectiveness of the retinoic acid when compared to retinoic acid-containing topical formulations otherwise identical except for the absence of a urethane compound.

Abstract: A preparation comprising a fat emulsion of fat microparticles wherein said emulsion contains a stabilizer consisting essentially of a fatty acid, a basic amino acid and a saccharide is provided. In the preparation comprising a fat emulsion of fat microparticles of the present invention, said microparticles having a mean particle diameter of at most 100 nm are stable, and so the microparticles remain in blood without being uptaken by liver. Therefore in case of administering a pharmaceutical preparation prepared by using the above-mentioned preparation of the present invention, the pharmacological activity may be expressed at a desired site. Thus the preparation is extremely useful as a drug carrier for drug delivery system.

Abstract: Disclosed herein is a process for preparing biodegradable microparticles comprising a biodegradable polymeric binder and a biologically active agent, wherein a blend of at least two substantially non-toxic solvents, free of halogenated hydrocarbons, is used to dissolve or disperse the agent and dissolve the polymer. The solvent blend containing the agent and polymer is dispersed in an aqueous solution to form microdroplets. The resulting emulsion is then added to an extraction medium preferably containing at least one of the solvents of the blend, whereby the rate of extraction of each solvent is controlled, whereupon the biodegradable microparticles containing the biologically active agent are formed.

Abstract: A solid composition for peroral therapy of cognition impairment is formulated to stabilize the acid labile drug, CI-979 HCl, by layering a mixture of thereof with a binder on mini-sugar spheres, and finally covering the structure with a protective coating.

Abstract: The invention relates to an anti-inflammatory factor isolated from milk, methods of purifying the anti-inflammatory factor resulting in substantially or highly purified preparations and to methods for using this factor to remove adhered neutrophils from endothelial cells, to prevent the emigration of cells from the vasculature and to suppress the response of lymphocytes to foreign antigens.

Abstract: The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-crystalline synthetic hydroxyapatite that provides both bioactivity and structural integrity. This novel amorphous material can be reacted with other calcium phosphates at or below 37.degree. C. to form a bone-like material consisting of poorly crystalline hydroxyapatite.

Abstract: A gate portion constituting a gate of a resin molding die is made of a hard alloy having a hardness greater than the predetermined hardness in the iron-based hard alloy used to form a cavity block and a center block. Opposing surfaces of the cavity block halves include a polytetrafluoroethylene layer at least at the portions thereof which contact portions of the lead frame in a semiconductor encapsulation molding apparatus.

Abstract: Injection molding apparatus comprising a platen, a die which is fixed to the platen and which defines a mold cavity having an inlet, a co-injection manifold mounted on the platen, the manifold including a nozzle housing having forward and rearward ends, the nozzle housing including an outlet which is located adjacent the forward end and which communicates with the mold cavity inlet, first and second spaced apart inlets which are located adjacent the rearward end and which are respectively adapted to communicate with first and second injection nozzles, a first passageway communicating between the first inlet and the outlet, and a second passageway communicating between the second inlet and the outlet.

Abstract: An apparatus for pelletizing a polymer melt, in which the polymer melt to be pelletized is divided in a housing of a pelletizing device into at least two part-streams, which are deflected and fed to at least two die plates which are spatially separate from one another and are heatable, whereupon the polymer melt streams are transformed into pellets by the cutting devices downstream of the die plates and are post-treated by means of a cooling medium.

Abstract: A dispenser for dispensing a paste-type material includes: a container charged with a paste-type material and provided at its one end with an extrusion tip, the container being collapsible in the longitudinal direction until the internal volume thereof is almost completely nullified; a cylindrical body opened at its both ends and having a diameter such that the container charged with the paste-type material is received in the cylindrical body; a piston sized to be insertable into the cylindrical body; and an extruder having a receiving portion for receiving the cylindrical body and having an operating portion. The operating portion is operable to cause a predetermined amount of advance of the piston into the cylindrical body received in the receiving portion so as to collapse the container in the longitudinal direction, thereby extruding a predetermined amount of the paste-type material from the extrusion tip of the container upon each operation of the operating portion.