Abstract: Cyclodextrins and other ecapsulating oligosaccharides can be bound to fibrous and/or polysaccharidic carriers by ionic bonds. The ionic bonds can be produced by introducing cationic or anionic groups into the cyclodextrins, and where appropriate, by introducing oppositely charged groups in the carrier material. The products can be used for odor control in the fibrous material.

Abstract: A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.

Abstract: This invention provides the use of a silicone-based transdermal therapeutic system having an area of 10 to 40 cm2 and containing 0.1 to 3.15 mg/cm2 of rotigotine as active ingredient, for the preparation of an anti-Parkinson medicament which induces a mean plasma concentration of rotigotine in the range of 0.4 to 2 ng/ml 24 h after administration.

Abstract: The present invention relates to the delivery of bioactive agents into cells. More specifically, the present invention relates to methods of using anionic liposomes to deliver bioactive agents, including oligonucleotides, plasmid DNA, RNA, proteins, and drugs, to non-dividing cells. The present invention also relates to compositions that include the anionic liposomes.

Abstract: The present invention concerns pulverulent mannitol characterized in that it has an average diameter of between 60 and 200 &mgr;m, preferably of between 80 and 180 &mgr;m, a packed density, determined according to a Test A, of between 0.65 and 0.85 g/ml, preferably of between 0.7 and 0.8 g/ml and a flow factor of at least 60, preferably of between 60 and 90a process for obtaining and using the said pulverulent mannitol as an excipient in preparations intended in particular for the pharmaceutical field, and especially as a powder for filling hard capsules.

Abstract: A synergistic antimicrobial textile finish comprising a synergistic antimicrobial combination of antibacterial agent selected from the group consisting of 2,4,4′-trichloro-2′-hydroxy diphenol ether and 2-phenylphenol, or a combination of these, and an antifungal agent of diiodomethyl-4-tolylsulfone, which provides for a synergistic antimicrobial textile finish that is nontoxic, stable, and imparts desired broad spectrum antimicrobial efficacy onto the surface of textile substrates.

Abstract: The invention is a composition and method for treating acute pain using a composition containing one or more NSAIDs. The preferred composition includes ibuprofen, sodium bicarbonate, Gelucire, and tartaric acid.

Abstract: There is provided a tablet preparation showing quick disintegratability in the mouth and good sensory acceptability and yet having an adequate strength to resist damage in the course of distribution. Each tablet comprises a starch, a water-soluble excipient and a medicament and does not substantially contain a binder other than starch.

Abstract: The invention relates to water soluble or water dispersible powders, tablets, or precursors therefor based on a carbohydrate matrix with improved dissolution properties in water. These components are subjected to treatment with a gas so that gas is entrapped therein, and sufficient closed porosity is provided so that gas entrapped therein promotes dissolution or dispersion upon contact with water. The powders or tablets may be pharmaceuticals or foods that optionally contain an active ingredient therein.

Abstract: An effervescent solid composition of matter is provided, which comprises, as an active component, a substance selected from chitosan, its derivatives and salts thereof and a second component capable of releasing CO2 in an acidic environment.

Abstract: A composition for oral, transdermal or subdermal administration to a subject is described. The composition contains: (a) an agonist component; (b) an antagonist component containing at least one antagonist and having a delayed time of release; and (c) an immediate release antagonist removal component, where the subject includes a gastrointestinal tract and the antagonist removal component is present in an amount sufficient to substantially remove the antagonist component from the gastrointestinal tract of the subject before the time of release of the antagonist component. The composition may be delivered to the subject by a method which includes the step of administering the composition orally, transdermally or subdermally to the subject. When the composition of the present invention is administered orally, the method of the present invention may include the step of administering a potassium compound to the subject.

Abstract: A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an optional water-insoluble binder is disclosed. The particles have a length of from about 0.1 to about 12 mm and can be of varying diameters and each unit dose provides a release of therapeutically active agents over at least about 8 hours. Methods of preparing the unit doses as well as extrusion processes and methods of treatment are also disclosed.

Abstract: Combinations of a carrier and a complex consisting of a nucleic acid molecule and a copolymer are described, wherein the copolymer consists of an amphiphilic polymer, preferably polyethylene glycol, and a charged effector molecule, in particular a peptide or peptide derivative, as well as their use for the transfer of nucleic acid molecules into cells.

Abstract: An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.

Abstract: Hard, dense particles of a pharmaceutical agent, suitable for administration to a subject via a needleless syringe are described. The particles are prepared by a multi step process that entails forming particles of a first size where the particles are an admixture of a pharmaceutical agent and a macromolecular carrier and the admixture has a first glass transition temperature; admixing a plasticizer that lowers the first glass transition temperature of the admixture to a second glass transition temperature which is below the first glass transition temperature; maintaining the articles at a temperature above the second glass transition temperature for a time period adequate to cause the particles to shrink and/or collapse; removing the plasticizer from the particles to yield modified particles having an increased glass transition temperature; recovering the modified particles; and then storing the recovered particles.

Abstract: The present inventive subject matter relates to amorphous drug beads comprising an amorphous active drug and an organic surfactant having improved solubility, absorption and wettability characteristics. The present inventive subject matter further relates to methods of preparing the amorphous drug beads, wherein molten drug beads are subject to a cooling step with or without shear.

Abstract: The present invention relates to controlled and sustained release pharmaceutical composition and processes for preparing the same. The present invention is to provide processes to prepare an injectable sustained release pharmaceutical composition comprising a step to prepare biodegradable porous microspheres having accessible ionic functional groups, a step to incorporate a biopharmaceutical into the microspheres through ionic interaction by suspending or equilibrating the microspheres in a solution containing the biopharmaceutical and a step to recover and freeze-dry the biopharmaceutical-incorporated microspheres.

Abstract: According to the invention, Applicants have identified a clarification process which is simple and quick and provides a protein isolate of greater than 90% whey protein which may then optionally be further purified to select out individual proteins. The process involves a number of steps, the order of which is critical, and novel lipid removal techniques to achieving the highly pure and clarified protein isolate of the invention.

Abstract: A method of using peracid/acid compositions, where the mole ratio of acid to peracid is less than about 3:1, to treat field or greenhouse grown plant tissue, seeds, fruits, and growing media and containers is described. The peracid/acid system can lower the natural, plant pathogen and human pathogenic microbial load resulting in less waste to molding, spoilage, and destruction because of pathogenic poisons.

Abstract: AIDS patients having a CD4+ T-lymphocyte cell count of 200 or less are treated by administration of a therapeutically effective amount of mammalian spleen extract, in combination with a therapeutically effective amount of Eleutherococcus extract.

Abstract: A beneficial material for medical application in association with a substrate comprises a support material and a reactive material. The reactive material is ion exchanged into the support material. The medical application may comprise a wound healing device, insect control adhesives and anti-microbial creams. The invention further discloses other beneficial materials, such as ionically conductive compounds, photoactive compounds and materials for medical application and methods of formulating same.

Abstract: The invention relates to compositions, methods, apparatus, and kits for alleviating or preventing vasoconstriction or vasospasm in a mammal. The compositions, methods, apparatus, and kits are also useful for alleviating or preventing ischemic tissue damage resulting from ischemia associated with cerebral vasoconstriction which follows aneurysmal subarachnoid hemorrhage, with embolic stroke, with coronary artery obstruction, and with other conditions. These compositions, methods, apparatus, and kits generally relate to adventitial (i.e., extra-luminal) administration of a nitric oxide donor compound to a blood vessel in a mammal.

Abstract: A method is provided for enhancing the solubility of an ionizable compound in a lipophilic medium by admixing the compound with an effective solubility-enhancing amount of an N,N-dinitramide salt. The ionizable compound, upon ionization, gives rise to a biologically active cationic species that ionically associates with the N,N-dinitramide anion N(NO2)2− following admixture with the N,N-dinitramide salt. The biologically active cationic species may be a pharmacologically active cation, in which case the method is useful for enhancing the penetration of the blood-brain barrier by the pharmacologically active cation. In other embodiments, the ionizable compounds are medical imaging or diagnostic agents, or agricultural agents such as pesticides. Salts of biologically active cations and N,N-dinitramide ion are also provided as novel compositions of matter.

Abstract: In a new pharmaceutical combination, the herb, Vitex agnus-castus (chasteberry), enhances hormone balance by increasing progesterone release and, therefore, ovulation frequency. The antioxidants, green tea, vitamin E, and selenium, improve overall reproductive health. L-arginine, an amino acid, stimulates the reproductive organs by improving circulation. Folic acid, vitamins B6 and B12, iron, zinc and magnesium help promote womens' fertility. Sperms are highly susceptible to free radical or oxidative damage from environmental toxicants and natural aging. Vitamins C and E, coenzyme Q10 and selenium are all potent antioxidants that help improve sperm counts and quality. Ferulic acid, an antioxidant found in Dong quai, also improves sperm quality. Zinc and B vitamins (B6, B12 and folate) are critical nutrients in male reproductive systems for hormone metabolism, sperm formation and motility. The amino acid, L-carnitine, promotes formation of healthy sperm.

Abstract: This invention describes a non-aqueous oral composition of molecular iodine in a stabilized hydrophobic environment containing a hydrophobe or combination of hydrophobes for treating different disease states.

Abstract: A method of reducing inflamation in a variety of disorders by using an intraperitoneal solution of magnesium. The solution can be used for treating inflammatory and inflammation-related disorders in animals and/or humans. Application of the solution reduces inflammation and thereby assists in the healing process. An alternative method involves the intraperitoneal administration of a solution containing magnesium salts. Another alternative method provides for treatment of inflammatory and inflammation-related disorders in animals by way of intraperitoneal administration of a solution containing magnesium salts, methenamine or its salts and dextrose. The method further provides the use of methenamine or its salts and/or dextrose in combination with magnesium.

Abstract: The present invention related to safe plant drug for treatment of liver disease, specifically, this invention proves a safe plant drug Schisandrin and its preparation. Schisandrin has the following pharmaceutical functions: increasing tumor suppresson genes express activity, decreasing activity of oncogenes, increasing immune function, increasing liver DNA synthesis, decreasing serum alamine aminotransferase activity, increasing glutathione level, increasing glutathione reductase activity, decreasing lipid peroxidation of liver, increasing hepatic microsomal monooxygenases activity, increasing ATP content in liver, increasing energy metabolism activity, decreasing density lipoprotein oxidation, protecting gastrointestinal function, increasing killer cell activity, increasing complement activity, decreasing induced liver cancer activity and decreasing grown of cancer cells.

Abstract: The present invention provides improved artificial blood fluids and microflow drag reducing factors for use in such fluids as well as the restoration and/or enhancement of microcirculation and tissue oxygenation. In accordance with preferred embodiments, artificial blood fluids with synthetic or natural oxygen carrying compounds are improved through the inclusion of small amounts of blood soluble microflow drag reducing factors. Microflow drag reducing factors may be combined with physiologically acceptable carriers to form fluids for the restoration and/or enhancement of microcirculation and tissue oxygenation. Physiologically acceptable carriers are preferred as those having a polyethylene glycol adjuvant. The concentration of microflow drag reducing factor is from about 0.1 ppm to about 10,000 ppm by weight of the blood fluid. Certain embodiments feature the employment of certain third and fourth generation dendritic polymers to improve emulsification of artificial blood fluids.

Abstract: Disclosed are stable, homogeneous dispersions, comprising (a) from about 20 to 90% by weight of a first composition comprising (i) about 60-95% by weight of a first polar solvent, (ii) about 0-40% by weight of one or more second polar solvents, and (iii) water soluble components of a first natural product; and (b) from about 10 to 60% by weight of a second composition comprising: (i) one or more apolar solvents, and (ii) oil soluble organic components of a second natural product; and (c) from about 0.01 to 8% by weight of a non-surface active lipid phosphate or a surface active agent. Also disclosed are methods of forming the stable, homogeneous dispersions of the invention, comprising forming a first composition comprising water soluble components of a first natural product; forming a second composition comprising oil soluble organic components of a second natural product; mixing the compositions and subjecting the mixture to high pressure high shear processing to form a stable, homogeneous dispersion.

Abstract: The invention features a method of identifying a pharmaceutical comprising compounds found in a plant extract by utilizing a genomic screen of the plant extract.

Abstract: Disclosed are a method for processing Panax spp., comprising the step of steaming Panax spp. under the oxygen-enriched atmosphere and a processed Panax spp. obtained by the method.

Abstract: Novel medicinal extracts derived from Allium species, preferably Allium cepa are provided. These extracts have broad medicinal properties, especially for treatment of ADS and other viral infections.

Abstract: The present invention is directed to a method for increasing the bone mineralization of a human, and more preferably an infant or toddler. The method comprises administering to said human a source of calcium and a fat blend that is low in palmitic acid. The enhanced mineralization results in the production of a higher peak bone mass and correspondingly lowers the incidence of osteoporosis.

Abstract: A method for preparing a Bowman-Birk inhibitor (BBI) product from soybeans is provided. The product produced in accordance with the method of the invention and compositions including the product are also provided. BBI product produced in accordance with the invention is a significantly improved inhibiter of malignant cell transformation and methods for its administration to prevent or inhibit progression of cancer are provided.

Abstract: The present invention relates to a novel pharmaceutical composition containing (+)-Cycloolivil and an additives, which is used as an antioxidant and is obtained from a new source namely Stereospermum personatum; the invention also provides a process for isolation the active compound (+)-Cycloolivil from a plant source namely Stereospermum personatum and use of the compound (+)-Cycloolivil as an antioxidant.

Abstract: Accordingly the present invention provides a process for the preparation an alcoholic extract with Carotenoids, UV absorption, antibacterial and pH indicating properties from a deep-sea bacterium which comprises a method for growing the cells in a medium with salinity ranging from 1.5 to 3% for 3-4 days at 28 +/−2° C. and harvesting them to prepare an extract which shows the properties of carotenoids (yellow/orange coloration), UV absorption, antibacterial and pH indicator properties.

Abstract: Process for operating a calender having a roll stack formed by a plurality of rolls resting against one another in a press direction along a stack plane, at least one of the rolls including an elastic surface. The process includes determining whether a barring pattern has occurred on at least one of the rolls, determining a wavelength of the barring pattern, and displacing at least one of the rolls based upon the wavelength.

Abstract: A system for molding optical attenuators that have a lens portion and a supporting portion includes a molding machine containing a mold, an extractor robot and optical inspection portion, and a controller that assesses the inspection information and send control signals to the molding machine and mold. The mold includes a cavity and a core which define a space in which the supporting portion and the attenuator are formed. The cavity and core are separable from each other by an actuating motor of the molding machine subsequent to each injection cycle to permit removal of each molded optical attenuator. The mold also includes a core pin, movably located in the core element. The core pin has a proximal end defining a surface of the lens portion and a distal end remote from the molding space. A core pin motor is coupled to the core pin, through a number of intermediate elements, so that the core pin can be moved relative to the core element to adjust a thickness of the lens portion.

Abstract: Discloses is an apparatus for injection molding permitting movement of the injection molding machine in multiple planes. The apparatus has a frame and an injection molding machine mounted within the frame. Located on both the frame and the injection molding machine are a plurality of interlocking rails and rail bearings. The movement of the rails in the rail bearings permits the injection molding machine to move relative to the frame. The frame is a two piece interlocking frame, the two pieces being capable of movement relative to each other.

Abstract: A device for producing an opening or cavity in the side of a ceramic product during product molding in a mould with a molding cavity delimited by a molding surface which has a window, comprising a deformable punch, joined on the window, designed to project into or retract from the molding cavity, with the ability to vary its rigidity. The device comprises punch shape variation differential constriction means and actuator means for punch deformation, which together produce a controlled anisotropic punch deformation, which makes the punch project into the molding cavity.

Abstract: An extruder die head for producing multilayered tubes made of thermoplastic material exhibits a central annular channel, which is provided with an annular outlet die. Into the outer limiting wall of the channel empty annular slits, which feed a polymer melt and which constitute the smaller diameter openings of truncated channels, formed between the internal and external shells of stacked, conical insert members. To reduce the axial length of the extruder die head, the annular slits, feeding the polymer melts, also empty into the inside wall of the central annular channel. Said annular slits are the smaller diameter openings of truncated channels, formed between the internal and external shells of stacked conical internal insert members.

Abstract: A conveying device that permits the continuous accumulation and intermittent injection a molding material is herein disclosed. The conveying device comprises a housing having a bore with an inlet and an outlet and a shaft reciprocable disposed within the bore. The shaft and bore are constructed and arranged to form an annular space therebetween. A slip ring is slidably captured on the reciprocable shaft and may travel longitudinally on the shaft between a forward position and a rearward position. When the shaft is retracted from the bore, the slip ring moves to its forward position on the shaft and the molding material may flow between an inner surface of the slip ring and the shaft. When the shaft is inserted into the bore, the slip ring moves to its rearward position and the slip ring acts as a piston head and forces the molding material from the bore and into a downstream molding or handling mechanism.

Abstract: The injection molding machine has an extruder for providing molding material, a cavity for retaining the molding material prior to injection into a mold, a plunger within the cavity to move the material out of the cavity, and a check valve. The check valve has separate means to permit the material to flow from the extruder to the cavity and from the cavity to an adjacent mold. By having separate flow channels for molding and recharging, the injection molding machine may be recharged on the fly.

Abstract: Methods of producing tableted gums and tableted gums so produced are provided. The tableted gums of the present invention include a tableting media and a gum component that includes gum chips. The gum component and tableting media are mixed and further processed to form the tableted gum wherein a substantial amount of the gum component is concentrated in a top portion of the processed tableted gum.

Abstract: The present disclosure relates to essentially dry compositions that are suitable for use as foods and/or beverages. Preferably, the essentially dry compositions are beverage compositions, wherein the compositions are diluted with a liquid prior to consumption. In a key benefit of the present invention, the compositions exhibit consistently good solubility despite the presence of relatively insoluble ingredients. In the various embodiments of the invention, the essentially dry compositions comprise a high intensity sweetener having properties which surprisingly provide enhanced solubility. Methods of providing sweetened, essentially dry compositions having enhanced solubility are also described.

Abstract: A method is disclosed for preparing an edible substrate such as a chocolate tablet having pellet shaped candy pieces arranged on the surface thereof in a predetermined defined pattern. Also disclosed is a novel chocolate confectionery prepared by the disclosed method and an apparatus for practicing the method.

Abstract: Carbohydrate-based glassy matrices which are stable in the glassy state at ambient temperatures may be prepared by the use of aqueous plasticizers with melt extrusion. Such glassy matrices are useful for the encapsulation of encapsulates, in particular, flavoring agents.

Abstract: An improved pet food snack and container for holding same and for providing and dispensing a dry pet food snack in combination with a highly palatable paste or sauce is provided. The container includes a tray, a dry food compartment formed in the tray having a unit of dry pet food and a wet food compartment formed in the tray having a quantity of wet pet food. The dry pet food compartment is spatially adapted to maintain a number of dry pet food units in a packaged order. The wet pet food compartment is preferably moisture impermeable. The wet pet food is preferably a flavored cream paste, includes oils and fats and is shelf stable.

Abstract: An improved pet food snack and container for holding same and for providing and dispensing a dry pet food snack in combination with a highly palatable paste or sauce is provided. The container houses separate first and second pet foods. The container has a removable lid that automatically places the first and second pet foods into contact when the lid is removed. The container has a bowl that holds the contacted first and second pet foods. The bowl is suitable for serving the contacted first and second pet foods to a pet. A pet owner can open the container and serve the contacted first and second pet foods without using any separate utensils.

Abstract: A method and apparatus are provided for at least partially sterilizing a liquid that has pathogens living in the liquid. The liquid comprising living pathogens is placed in a reaction volume, and a non-thermal plasma is generated within the reaction volume to thereby kill at least a portion of the pathogens within the liquid.