Abstract: A self-propelled endoscopic micro-robot, comprising a head for obtaining the errorless information of an interior of a tubular organ; an impact force generating unit connected the head generating an impact force according to a pneumatic pressure externally supplied and sucked by a air pressure supplier and making the self-propelled endoscopic micro-robot move in the tubular organ; and a plurality of supporting arms connected the head with end of the impact force for covering the impact force generating unit, making a housing of the self-propelled endoscopic micro-robot, and adjusting frictional force between the interior of the tubular organ and the housing as desired.

Abstract: A device for moving a tool along a passage, particularly for use in medical procedures, has two different aspects. In one aspect, a tool, e.g. a colonoscope, is surrounded by a sheath. The sheath has an inflatable region for engaging the passage wall, e.g. a colon. An annular extension region of the sheath is provided which becomes part of the inflated inflatable region thereby increasing its length as the fluid pressure acts against a head of a tool to draw the tool along the passage. The annular extension region has sheath parts which face one another by their relative orientation caused by crumpling of the extension region, or the sheath parts are provided by folded portions. The extension region moves together with the tool as the sheath parts sequentially move into the inflated inflatable region. In the other aspect, after inflation of the inflatable region of the sheath, inflation pressure acts against an inflatable head carried at the distal end region of the tool to draw the tool along the passage.

Abstract: A real-time computer-based viewing system is disclosed comprising a database of pre-existing software objects, wherein at least one of the software objects corresponds to a physical structure which is to be viewed by the system and at least one of the software objects corresponds to a graft which is to be deployed adjacent the physical structure, a real-time sensor for acquiring data about the physical structure when the physical structure is located within that sensor's data acquisition field, generating means for generating an additional software object corresponding to the physical structure using data acquired by the sensor, registration means for positioning the additional software object in registration with the pre-existing software objects contained in the database, and processing means for generating an image from the software objects contained in the database, based upon a specified point of view.

Abstract: A bending manipulation device for endoscope wherein a pair of control wires are taken up by a pulley provided in and given a rotary motion by the main control portion of the endoscope, and one of control wires extended out from the pulley corresponding to the turning operation thereof is taken up by the pulley while the other is paid out from the pulley, thereby enabling the bending manipulation to be carried out. The groove of the above pulley is formed in the shape of a spiral continuously extending in the peripheral direction of this pulley and is used in common by the above pair of control wires. One part from the one end of the groove and the other part from the other end of the groove are arranged side by side and in parallel with each other. Each of control wires is alternately taken up on the groove of the pulley corresponding to the turning direction of the pulley.

Abstract: A portable endoscope has a liquid supplying tube that transmits liquid to the tip of the endoscope, a container that is spatially connected to the liquid supplying tube and stores the liquid, a gas supplying tube that is connected to an inside space of the container and transmits gas to the tip of the endoscope, a liquid and gas supplier that supplies the liquid in the container to the liquid supplying tube and supplies the gas to the gas supplying tube, and a holder that holds the container such that the container generally keeps a horizontal position.

Abstract: A holder for holding parts of a body, structure or assembly spaced apart during operations carried out on the body, structure or assembly, the retractor comprising a body made of wire and having a resilient hinge portion at a vertex of the body and at least two arms outwardly extending from the hinge portion, each arm having a distal portion including anchoring tips.

Abstract: A surgical speculum for use for vaginal insertion that may be used for treatment of a bartholin gland is provided. The speculum has a pair of blades in facing relation to one another and each having a distal end and a proximal end. The blades each undergo an angular transition at a point between their distal ends and their proximal ends. At least one of the blades has an opening in its center that extends on either side of the angular transition.

Abstract: A medical device for retracting tissue allows access to the inside of the body by “prying open” an existing or created opening in a body. The device comprises a substantially transparent head having first and second head halves defining a substantially conical surface including a gap when the first and second head halves are joined. Angular motion of the first and second head halves enlarges the existing or created opening and provides an area of access to the inside of the body. The substantially transparent nature of the device allows it to function as a light pipe so that the operator can see the body cavity or tract opened by the device. The device has scissors-like handles to allow an operator to open or close the device with one hand.

Abstract: Alcohol is used as a coupling medium between an ultrasonic transducer and patient skin providing rapid settling of quantitative measurements.

Abstract: An ultrasound probe is placed on the head of a patient, and is used to generate an ultrasound pulse which propagates through the skull and brain of the patient, and is reflected off of the skull and soft tissue lying in a path perpendicular to the ultrasound probe. A portion of a generated Echo EG signal is then selected, and the Echo EG signal is integrated over the selected portion to generate an echo pulsograph (EPG) signal. Using an ECG signal as a reference, the EPG signal is used to provide information regarding the physiological state of the tissue at a depth from the ultrasound probe corresponding to the selected portion of the Echo EG signal.

Abstract: A method including positioning a catheter at a location in a blood vessel; imaging a thickness of a portion of a wall of the blood vessel at the location; identifying a treatment site; advancing a needle a distance into the wall of the blood vessel to the treatment site; and introducing a treatment agent through the needle to the treatment site. A composition including an inflammation-inducing agent and a carrier in the form of microspheres having a particle size suitable for transvascular delivery. A composition including a therapeutic angiogenesis promoter in a carrier and an opsonin-inhibitor coupled to the carrier. An apparatus for delivery of a therapeutic angiogenesis promoter.

Abstract: Method and apparatus for 3D/4D ultrasonic imaging. An array of ultrasonic sources and receivers (7) positioned over or near tissue (6) transmit short encoded omnidirectional ultrasonic shots (9). The amplitude and phase of the resulting reflected waves (10) are detected, sampled and digitised. Traces from each shot are reconstructed by digital data processing. A three dimensional data volume is constructed corresponding to reflection amplitude through a regular volume. The data volume may then be imaged through any arbitrary plane. Time varying images can be readily produced as the process takes only a fraction of a second.

Abstract: An ultrasound system for assessment of distance between an area of interest and a known location of a non-bone canal for use in drilling in an implant receiving cavity in the alveolar bone of a human subject's posterior mandible or posterior maxilla. The system comprises an ultrasound probe capable of being introduced at the area of interest and transceiving pulse echo ultrasound signal to the alveolar bone and therefrom and an electronic circuitry for processing the ultrasound signal and providing an indication of the remaining alveolar bone distance between said ultrasound probe and a canal within the alveolar bone.

Abstract: An acoustically generated image includes only selected acoustical components. When an original acoustic signal interacts with an object, the resultant acoustic signal comprises a diffracted component and an undiffracted component. The acoustical images of the present invention are generated with either the diffracted component only or the undiffracted component only. In an alternative embodiment, the acoustically generated image may comprise selected frequency component(s) from the diffracted component of the acoustic signal.

Abstract: A connector assembly connects an ultrasound transducer to an ultrasound catheter that has an ultrasound transmission member extending longitudinally therethrough. The connector assembly has an ultrasound transducer having a transducer housing, and an extension having a proximal end attached to the distal end of the transducer housing. The connector assembly also includes a ring assembly having an inner ring and an outer ring that is received inside the bore of the outer ring. The connector assembly also includes a catheter knob having a proximal end that is removably coupled to the extension. The inner ring is moved from a non-supporting position with the extension positioned inside the bore of the inner ring, to a supporting position with the catheter knob positioned inside the bore of the inner ring.

Abstract: An optical guide for a biopsy needle includes a light projector for producing a line image on a patient's skin surface, wherein the light projector is adapted for mounting on an ultrasound transducer such that the line image corresponds with an intersection of the transducer ultrasound plane with the skin surface.

Abstract: The invention provides a nested tubing cannula which comprises outer and inner elongate tubular members, both having a proximal end, a distal end, and a lumen therebetween. The inner tubular member is sealed at its distal end and is nested substantially coaxially within the lumen of the outer tubular member, so that the gap between the inner and the outer tubular member defines a second lumen whereas the first lumen is the lumen of the inner tubular member. A tubular sleeve is disposed coaxially between the inner and outer tubular members. A balloon is mounted on a distal region of the outer tubular member and is in communication with the first lumen. The cannula further comprises a port proximal or distal the balloon occluder and is in communication with the second lumen. Methods for making the devices herein are disclosed.

Abstract: A scanning system for obtaining an optimal image of a selected part of a patient, wherein the selected part varies cyclically over time. The scanning system comprises (1) scanner for scanning a cross-section of a selected part of the patient to generate a time-wise series of images of the cross-section; (2) image processing submodule for analyzing the time-wise series of images to determine a state of the selected part as shown in each image in the time-wise series of images; (3) image selection submodule for selecting the optimal image from the time-wise series of images based on the state of the selected part in the optimal image; and, (4) memory for storing the optimal image.

Abstract: A pleth signal is analyzed to identify a heart rate variability parameter associated with respiration rate. In one embodiment, an associated process involves obtaining a photoplethysmograpic signal, processing the pleth signal to obtain heart rate samples, monitoring the heart rate sample to identify a heart rate variability associated with respiration, and determining a respiration rate based on the heart rate variability. The photoplethysmographic signal may be based on one or more channel signals of a conventional pulse oximeter. The invention thus allows for noninvasive monitoring of respiration rate and expands the functionality of pulse oximeters.

Abstract: An apparatus for measuring a blood pressure of a superior limb or an inferior limb of a living subject, including a blood-pressure measuring device which includes a measuring member adapted to be worn on a measurement portion of the superior or inferior limbs and measures a blood pressure of the measurement portion, and a pressing device which includes a pressing member adapted to be worn on the measurement portion or a distal portion of the subject relative to the measurement portion, and which presses the pressed portion with a prescribed blood-flow promoting force that is lower than a systolic blood pressure of the subject.

Abstract: An apparatus for inspecting arteriosclerosis of a living subject, including a pulse-wave detecting device which detects a pulse wave from a portion of the subject, an augmentation-index determining device for determining, based on the pulse wave detected by the pulse-wave detecting device, an augmentation index indicating a proportion of a reflected-wave component of the pulse wave to an incident-wave component thereof, so that the arteriosclerosis of the subject is inspected based on the augmentation index determined by the augmentation-index determining device, a waveform-related-information obtaining device which obtains waveform-related information that is related to a change of a waveform of the pulse wave detected by the pulse-wave detecting device, a display device, an augmentation-index displaying device for operating the display device to display the augmentation index determined by the augmentation-index determining device, and a waveform-related-information displaying device for operating the displ

Abstract: An adapter for interfacing a pyro/piezo sensor to a polysomnograph machine comprises a differential input amplifier coupled to receive the raw transducer signals from a PVDF film transducer to provide a requisite gain while rejecting common mode noise. The resulting amplified signal is filtered to separate the pyro signal from the piezo signal and the piezo signal is further applied to half-wave rectifier stages that function to remove baseline noise from the piezo signal before its being applied to a microphone channel of an existing PSG machine.

Abstract: A method of diagnosing neurological impairments such as multiple sclerosis includes the determination of the simultaneity threshold of a pair of sensory stimuli, such as visual or tactile stimuli, separated temporally by a stimulus onset asynchrony (SOA). The stimuli may be presented unilaterally or bilaterally. Interhemispheric transfer times may also be determined by determining the difference in simultaneity thresholds for bilateral and unilateral presentations. Simultaneity thresholds and interhemispheric transfer times are significantly elevated in patients with MS and other neurological impairments. An apparatus for delivering such sensory stimuli includes an array of visual stimuli and tactile stimulators, a computer-implemented control program and a precise timing mechanism.

Abstract: An apparatus for examining a subject's brain functions acquires two or more indexes of pupillary indexes that show the subject's pupillary characteristics, visual indexes that show the subject's visual system functions, intelligence evaluating indexes that are results of the an intelligence test carried out on the subject, and behavior evaluating indexes that show the results the subject's behavior examination. Two or more indexes are stored in a memory and outputted from an output unit. By combining two or more kinds of independent indexes, accurate determination of dementia cases and further the degree of senescence of brain functions can be achieved. In addition, the brain function examining apparatus puts together a number of a plurality of indexes by the multivariate calculation and converts the indexes into different values of fewer numbers.

Abstract: A hearing screener apparatus is provided. In one embodiment, the hearing screener comprises a housing, a testing probe and one or microphones mounted with the testing probe. An elastic coupler may be used to suspend the testing probe from the housing. The testing probe may include a shaft and a removable probe tip mounted on the shaft. An ear tip is fitted onto an end of the removable probe tip. The ear tip may have a flexible flange arranged at its end to seal within the ear canal of the patient. The screener allows the testing probe to be manipulated about all axes and may have an isolation body or assembly that acts as the elastic coupler. The elastic coupler provides vibrational noise isolation due to movement of the patient and the user.

Abstract: An intra-vaginal self-administered cell collecting device and method includes inserting a tampon-like telescoping tube intra-vaginally. The tube includes an expandable preformed absorbent member having a textured cover. The absorbent member also includes a retrieval member extending therefrom. The tube is manipulated to expel the absorbent member intra-vaginally. The tube is removed and the absorbent member is retained intra-vaginally for a period of time. The absorbent member is retained from expanding from its preform when exposed to vaginal fluids by means of a cover on the absorbent material. The cover also captures soughed-off cells in the vaginal fluids. The absorbent material is retrieved manually by the retrieval member.

Abstract: The biopsy device has a biopsy channel connected to an aspiration and collecting chamber and at least one application channel connected to a dispensing chamber integrally connected with the aspiration chamber. The application channel is formed by a tube centrically slipped over the biopsy channel wall. To enable the collection of tissue specimens without tissue specimens entering and obstructing the application cannula, the distal segment of the application channel forms a close fitting and concentric sheath around the biopsy channel. The proximal end of the application channel has a larger diameter than the distal end allowing for unobstructed flow of the application material past the biopsy channel wall upon retraction of the biopsy channel from the distal segment of the application channel.

Abstract: A vibration assisted needle device is disclosed for use in medical procedures, such as needle aspiration biopsies. Reciprocation of the needle, such as a biopsy needle, eases the advance of the needle through tissue, penetration of the site of interest and the collection of sample at a site of interest. The device comprises a housing defining a chamber, a needle support external to the chamber for supporting a needle and a mechanism in the chamber for causing reciprocatory motion of the needle support. The needle support is preferably external to the housing. A syringe support may be connected to the housing for supporting a syringe. The reciprocatory mechanism may comprise means for converting rotational motion into reciprocating motion, such as a bearing or a rotor with a circumferential, angled groove on its surface, coupled to the needle support. The bearing or the rotor may be driven by a rotational motor, preferably located outside of the housing, or by a hydraulically driven turbine within the housing.

Abstract: An intravascular guide wire having at least two core materials joined together without the use of a hypotube. There is a core having a proximal core section with a proximal end and a distal end and a distal core section with a proximal end and a distal end. The distal end of the proximal core section and the proximal end of the distal core section are ground into complementary shapes, and then placed into a fixture in opposing directions with a small gap in-between the ends to receive a mass of hardened material to wick therein. Once the proximal and distal core sections are bonded, welded, brazed, cemented, or soldered together, the guide wire is then ground to a required outer diameter, depending on the design needs of the specific guide wire.

Abstract: Apparatuses and methods are provided to reconstruct an enlarged left ventricle of a human heart, using a shaper, having a size and shape substantially equal to the size and shape of an appropriate left ventricle, wherein the shaper is adapted to be temporarily placed into the enlarged left ventricle during a surgical procedure. Another aspect of one embodiment comprises a ventricular patch adapted for placement into the left ventricle of a heart made from a sheet of biocompatible material, and having a plurality of markings coupled to the sheet, wherein the markings are configured in distinct patterns for post operatively evaluating movement of the patch. In another aspect of one embodiment, a device is presented, comprising of a handle and a sizing template adapted to be coupled to the handle. Such components are also presented as a kit for use during ventricular restoration surgery.

Abstract: Apparatus and methods relating to plethysmographic measurement of infant body composition are provided. A tray for receiving the infant subject to be measured is coupled to a sliding mechanism that slides the tray in and out of a plethysmographic measurement chamber, thereby reducing the footprint of said chamber and facilitating infant comfort during measurement. Further, an integrated weighing function is provided that determines the infant's weight while conducting body composition measurements.

Abstract: A mouth supported tongue/hard palate pressure sensor allows pressures to be measured between the tongue and hard palate in an environment that closely approximates the configuration of the tongue and mouth during natural swallowing to provide diagnosis and therapy for swallowing disorders.

Abstract: Massage apparatus consisting of a treatment head connected to a suction circuit, the said treatment head comprising a box (B) that can be operated manually, comprising an internal chamber (C) open at its base, which chamber is defined by two fixed side walls (P1, P2) and two transverse surfaces (T1, T2) arranged facing one another between the two side walls (P1, P2), at least one of these surfaces (T1) consisting of the periphery of a roller (1) driven positively in rotation, the suction circuit opening into the said chamber (C) and making it possible to create suction when the apparatus is applied against the body of the patient, which suction tends to form a fold of skin pressing against the transverse surfaces (T1, T2), characterized in that the positive drive of the roller (1) is obtained via a geared motor unit mounted fixed and coaxially inside it, and in which the output shaft (5) of the reduction gear comprises means of coupling to the said roller (1), the said apparatus being associated with means fo

Abstract: A multisensory stimulation system and method of use. The system includes a housing articulate on a support so as to align a marked viewport with an individual. The housing defines a viewing chamber which is an extension of a reflective light and image optical system chamber which receives light and images from one or more video monitors or images projectors and, in some embodiments, from alternate sources such as black lights and strobe light devices. The system also includes an aromatic sensory component, tactile sensation devices, an audio input system, and audio delivery devices.

Abstract: An apparatus for bending and stretching a foot of a living person by pressing at least an arch of a sole of the foot and stopping the pressing of the arch.

Abstract: A device for thinning lung secretions comprises a housing, a reed disposed in the housing, and an acoustical resistance. The reed produces a low-frequency audio shockwave when vibrated. The acoustical resistance couples a patient's lungs to the audio shockwave and creates a back pressure of the low-frequency shockwave into a patient's lungs.

Abstract: A posterior lumbar lordosis orthotic device includes front and back panels and sides. The back panel is shaped to simulate the lordosis of an individual and has upper and lower regions angularly related to one another. Screws accessible from the inside of the back panel are rotatable to adjust the angle between the upper and lower regions to more closely accommodate the specific lordosis of an individual. The front panel is secured to the sides, using modified pop rivets, enabling the front panel and sides to be adjustably secured to one another to adjust the overall girth of the device and to differentially adjust the girth along upper and lower portions of the device to accommodate individuals of different waist and hip sizes.

Abstract: An ambulatory support device includes two support belts configured to be positioned around a user's body. At least one of the support belts includes a canting mechanism that couples opposing portions of the support belt. The canting mechanism allows the opposing portions to rotate about associated pivots to allow the support belt to conform to the user's body and synchronizes the movement of the opposing portions of the support belt such that movement of one portion causes a substantially equivalent movement of the other portion. The support device also includes one or more support mechanisms. Each support mechanism is coupled between the support belts and provides stability to the user's body.

Abstract: A restriction splint for immobilizing the CMC joint of a hand includes a splint body of a soft stretchable material that overlies the dorsum and palm of the hand and a tensioning strap having one end connected to the splint body at the dorsum and a free end wrapping around the CMC joint capsule, extending through the web between the thumb and the index finger and releasably connected to the splint body under extension for orienting and immobilizing the thumb without consequent loss of hand functioning.

Abstract: A system for establishing differential perfusion without the use of an occlusion balloon or other flow separator devices. The flows through two lumens are controlled such that the blood flow issuing from one lumen terminating in the aortic arch supplies the entire demand of the cerebral subcirculation while the blood flow issuing from a second lumen terminating in the descending aorta supplies the entire demand of the corporeal subcirculation. When the two flows are properly balanced, an inversion layer forms therebetween and no intermixing of the two flows takes place.

Abstract: A method for measurement of mass and energy transfer parameters (clearance and dialysance) in hemodialysis. A sensor is provided in the dialysate flow path downstream of the dialyzer and means are provided to add concentrate upstream of the dialyzer. A pre-determined amount of a substance whose dialysance is to be measured is added upstream of the dialyzer. The amount of substance riot dialyzed in the dialyzer is measured downstream of the dialyzer by said sensor by integrating the concentration over time. Dialysance is calculated from the amount added upstream, the amount measured downstream and the dialysate flow. In case the substance is part of the dialysate the base concentration is subtracted during integration. The addition of the concentrate upstream of the dialyzer can be done manually or, alternatively by the mixing pump of the dialysis machine. Instead of an increase of the concentration with a concentrate dilution with water can be used as well.

Abstract: A method and device for improving blood circulation to an area of interest within a patient' heart is described. The method comprises inserting a guidable elongated flexible ultrasound device into a patient's vasculature, applying ultrasonic energy to an area in need of improved circulation, and injecting materials such as angiogenic materials or contrasting agents into the area of interest. The device, suitable for performing the method, comprises an elongated tubular body, a distal head of the elongated tubular body for introducing ultrasonic energy to an area of interest, and a needle to deliver materials to an area of interest.

Abstract: A catheter including a catheter tube and a bolus tip, the bolus having a radially extending main side port. In one embodiment the catheter also has second and third side ports axially spaced from said main side port. The second and third side ports are each axially elongated, with an edge which is semi-circular in cross-section. The second side port is displaced 180° from the main side port. The third side port is axially aligned with the main port. The catheter is thickened in a dimple opposite each of the second and third side ports. Another catheter embodiment specifically for hemodialysis includes a dual lumen tube with a bolus at its distal end. A main venous port is formed in one side of the bolus adjacent the bullet nose of the bolus. Variations of this embodiment utilize a bolus with a 13.5 French tube connector section and a 10 French nose section, with the venous port formed in the nose section.

Abstract: Apparatus for intracardiac drug administration, including a catheter which is inserted into a chamber of the heart and brought into engagement with a site in the heart wall. The catheter includes at least one position sensor, which generates signals responsive to the position of the catheter within the heart, and a drug delivery device, which administers a desired dose of a therapeutic drug at the site determined responsive to the signals from the position sensor.

Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The automatic injection device includes a dry compartment located within a housing for storing a predetermined dry charge of the medicament therein, a wet compartment within the housing for storing a predetermined amount of liquid injection solution therein, an activation assembly for causing the liquid injection solution in the wet compartment to be transferred to the dry wet compartment, and at least one compression assembly for maintaining the medicament located in the dry compartment under a continuous compressive state as the liquid injection solution passes through the dry compartment.

Abstract: A wearable, self-contained drug infusion device is disclosed that is capable of achieving the precise flow rate control needed for dose-critical drugs such as insulin. In preferred embodiments of the device, at least two flow channels are utilized in conjunction with a series of valves for providing a user with selectable, constant flow rate control. The device can be made with small dimensions so that it can be worn by the user with a minimum of discomfort and inconvenience. In addition, the simple mechanical nature of the device provides the user with close control over the flow rate, which is required for safe and effective delivery of insulin and other drugs. Also, the absence of electronic components allows the device to be manufactured inexpensively. The device is provided with a first channel that is long and narrow, functioning as a flow restrictor. The first channel is preferably provided in a serpentine pattern.

Abstract: A steering configuration for facilitating steering of a catheter or the like provided with a rigid distal device employs a flexible support element to which a rigid device is attached at its distal end. At least one elongated flexible control element is configured such that tension applied to the control element causes flexing of the flexible support element. The control element is directly attached to the rigid device, thereby rendering the rigid device an operative extension of the steering mechanism.

Abstract: A stiffenable balloon catheter assembly capable of being converted from an “over-the-wire” mode with respect to a guidewire extending therethrough to a “rapid-exchange” mode with respect to a guidewire extending therethrough, and vice versa. The catheter has a plurality of lumens, one lumen however, having a side opening with an obstructable galp, the orientation of which, determines the utilization “mode” of the catheter assembly. Stiffening stylets may be adjustably locked into the lumens, depending upon the “mode”, to control the stiffness of the catheter assembly during its utilization within a patient.

Abstract: This is a balloon catheter having at least two lumens. One of the lumens is a large working lumen. The balloon catheter is especially useful as a guide catheter and may be used in a variety of therapeutic and diagnostic procedures. In particular, it has value in treating neurovascular embolic strokes in combination with other devices which are delivered to the stroke site through that working lumen. The remainder of the lumens typically are used to inflate and to deflate the balloon. It is highly preferable that the balloon or inflatable member be situated in a recess in the outer wall of the inventive catheter. Additionally, the distal end of the catheter past the balloon is preferably tapered. The catheter has a very low profile as compared to other catheters of the neurovascular balloon catheter genre. It may include other features such as variable stiffness along the axis of the device and anti-kinking components. The balloon is preferably compliant in nature.

Abstract: An endovascular catheter device capable of heat and gas exchange with a patient's bloodstream comprises a catheter shaft, a heat exchanger, and a gas exchange element. The heat exchanger and the gas exchange element are in fluid communication with one or more internal lumens of the catheter shaft. The catheter shaft may be connected to a control system that permits a heat exchange fluid to be delivered to the heat exchanger, and that permits a gas to be delivered to the gas exchange element. The catheter device may also comprise one or more flow disruption devices to disrupt the laminar flow of blood around the catheter device. The catheter device may be used to cool and oxygenate a patient's blood, and improve organ function.