Abstract: A method of manufacturing a composite uses a hybrid tool which serves both as a form on which constituent materials are applied for bonding or curing into a part in a desired configuration, and as a fixture for holding the bonded or cured materials in the originally applied position during subsequent machining of a peripheral edge of the part. The method includes fabricating a face sheet of composite material having a facing surface configured to the reverse of a desired shape of one surface of a part to be made on the tool. The materials for the part are applied on the face sheet, debulked, bonded or cured, and edge trimmed thereon, all while on the face sheet in the originally applied position.

Abstract: Blow-molding molds 10 and 20 having parison shutters 31 and 32 for preventing an inflation of the parison 3 toward the outside of the molds 10 and 20 are used in a blow-molding method of the present invention. In other words, a closed space for preventing the parison 3 from inflating out of the molds 10 and 20 are formed by the parison shutters 31 and 32 and a predetermined air is secured in the parison 3 in a frame clamping step (B). In the subsequent mold clamping step (C), the pressure inside the parison 3 starts to be increased when the molds 10 and 20 press the parison 3, so that the parison 3 can be continuously in contact with the die design surface 11. Accordingly, since the parison 3 can be uniformly contracted by cooling, molding failure such as streaks and uneven pattern transfer can be avoided, thus obtaining a blow-molded product having good appearance.

Abstract: A metal injection-molding feedstock is heated and plasticized. Supercritical carbon dioxide is injected into the feedstock to form micropores when the pressure is reduced and a parts mold is filled. The micropores are retained when the green parts are debindered and sintered.

Abstract: The present invention relates to a method of manufacturing sputtering targets doped with non-metal components including boron, carbon, nitrogen, oxygen and silicon. A powder process is utilized whereby alloyed powders, which contain non-metal elements of B/C/N/O/Si and non-metal containing phases of less than ten microns in microstructure, are blended, canned and subjected to hot isostatic press consolidation. The sputtering targets of the present invention avoid spitting problems during sputtering of the target material on a substrate.

Abstract: A process for sanitizing a fabric article which is contaminated with one or more microbials. The process steps include: (a) placing the fabric article in a vapor venting bag together with a cleaning/refreshing composition comprising water; and (b) subjecting the vapor venting bag to a heat source which supplies sufficient heat to vaporize the water, thereby exposing the microbials to the resulting water vapor. This process results in at least about 50% of the microbials being killed. The cleaning/refreshing composition preferably comprises at least one antimicrobial agent selected from the group consisting of 5-chloro-2-(2,4-dichlorophenoxy)phenol, trichlorocarbanalide, hydrogen peroxide, other oxygen bleaches, 4-chloro-3,5-dimethylphenol, iodine/iodophors, chlorhexidine, phenols, phospholipids, thymol, eugeniol, geraniol, oil of lemon grass, limonene and mixtures thereof.

Abstract: Systems and methods for processing blood use at least one fluid activated pump and at least one fluid activated valve. The systems and methods apply positive and negative fluid pressures to operate the pump and valve. Different pressure conditions are applied to the pump and the valve, to insure that a valve used in conjunction with a pump is not overcome by the pressure applied to operate the pump, and that both the valve and pump are not overcome by normal system processing pressures.

Abstract: An apparatus for blood oxygenation and delivery is provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly with a pressurizable chamber having inlets for a first gas-supersaturated fluid and a second fluid, such as blood. The inlets are advantageously positioned on the mixing chamber in such a way that the first fluid and the second fluid enter the mixing chamber normally to each other to promote mixing and liquid-to-liquid gas transfer. The apparatus also includes a delivery system coupled to the blood oxygenation assembly. The delivery system includes a generally tubular elongated member having a proximal end portion, a distal end portion, and a transition portion located between the proximal end portion and the distal end portion. The transitional portion is relatively flexible compared to the proximal end portion and is relatively stiff compared to the distal end portion.

Abstract: A self-contained analyzer quantitatively detects a clotting event in a biological fluid. The device includes a base having an open reservoir for receiving the biological fluid. A carrier for a dried activator reagent is located in or adjacent to the open reservoir. The biological fluid reconstitutes the dried reagent and starts the clotting process. During the clotting process the fluid travels through a capillary flow channel lined with a precision woven fabric. When clotting is completed, the woven fabric stops the flow of the fluid. A colored bar formed by the fluid flowing through the capillary channel indicates the length of time required for clotting of the sample.

Abstract: Chemical sensors for detecting the activity of a molecule or analyte of interest is provided. The chemical sensors comprise and array or plurality of sensors that are capable of interacting with a molecule of interest, wherein the interaction provides a response fingerprint. The fingerprint can be associated with a library of similar molecules of interest to determine the molecule's activity and diffusion coefficient.

Abstract: A stackable non-stick coverslip is disclosed and includes a glass plate in combination with a protuberance on the upper surface thereof and/or an adhesive on the bottom surface thereof. The protuberance provides an elevational alternation that defines a supporting plane for an adjacent coverslip. The supporting plane provides a gap between adjacently stacked coverslips, thereby avoiding adherence and sticking. The adhesive secures the coverslip to a glass slide.

Abstract: A pin holder for a microarraying apparatus comprising at least one group of bodies of circular cross-section packed together to form a network of pathways in gaps between the bodies; and an array of pins slidably arranged in the pathways. The pins are held in parallel to each other automatically as a result of the self organized packing of the circular cross-section bodies, which may be spheres, for example ball bearings, or cylindrical, for example needle roller bearings. The pin holder provides for very accurate parallel alignment of the pins, low pin friction, as well as low cost and complexity of manufacture.

Abstract: A modular microchannel apparatus for analysis of an analyte. The apparatus includes a separation unit and a reservoir unit. The separation unit has a microchannel. The analyte can be driven to pass through the microchannel such that the time for the analyte to pass through the microchannel is indicative of the molecular characteristics of the analyte. The reservoir unit has one or more reservoirs for coupling operatively modularly with the separation unit to supply liquid reagents to the separation unit. The reservoirs has prepackaged liquid reagents in it before the reservoir unit is coupled with the separation unit.

Abstract: A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures, and a cannula for introducing fluid reaction material into the vessels. A robot system is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including slurries, to respective vessels, and to withdraw the cannula from the cannula passages after delivery. Related methods are also disclosed.

Abstract: A pollution control device that includes a housing, a pollution control element, and a sheet of mounting material. The mounting material is positioned around the monolith in a specific configuration to provide a tight fitting insulating wrap about the outer surface of the monolith. The sheet of mounting material is positioned such that at least a portion of the mating edges meet to form a seam that is non-perpendicular to the inlet and outlet of the monolith.

Abstract: A compact, multitube steam reformer converts a fuel into a reformate stream comprising hydrogen. In one embodiment, the reformer comprises a closed vessel and a burner disposed within the vessel. The burner comprises a start fuel manifold for receiving and distributing a start fuel stream, an oxidant manifold for receiving and distributing an oxidant stream, and a burner fuel manifold for receiving and distributing a burner fuel stream. The oxidant manifold comprises a plurality of oxidant distribution tubes, each having an inlet end and an outlet end, disposed in a separator member. The burner fuel manifold comprises a plurality of burner fuel distribution tubes, each having an inlet end and an outlet end. The burner fuel distribution tubes extend through the start fuel manifold and the oxidant manifold and are fluidly isolated therefrom.

Abstract: A sterilization container system for sterilizing instruments provides at least two sterilization enclosures separated vertically by a stacking device. The stacking device allows diffusion between the enclosures and into the enclosures through their upper and lower facing portions.

Abstract: A system for abating undesired component(s) from a gas stream containing same, such as halocompounds, acid gases, silanes, ammonia, etc., by scrubbing of the effluent gas stream with an aqueous scrubbing medium. Halocompounds, such as fluorine, fluorides, perfluorocarbons, and chlorofluorocarbons, may be scrubbed in the presence of a reducing agent, e.g., sodium thiosulfate, ammonium hydroxide, or potassium iodide. In one embodiment, the scrubbing system includes a first acid gas scrubbing unit operated in cocurrent gas/liquid flow, and a second “polishing” unit operated in countercurrent gas/liquid flow, to achieve high removal efficiency with low consumption of water. The scrubbing system may utilize removable insert beds of packing material, packaged in a foraminous containment structure. The abatement system of the invention has particular utility in the treatment of semiconductor manufacturing process effluents.

Abstract: A method for removing an acidic component such as sulfite gas (SO2) contained in an exhaust gas comprising by using a system comprising (a) a gas-liquid contact apparatus composed of an absorption column provided internally with at least one perforated plate at the top, bottom, or both top and bottom of the absorption column packed with at least one type of fillers, (b) an apparatus for introducing raw seawater to the absorption column, (c) an apparatus for oxidizing the seawater after gas-liquid contact, and (d) an apparatus for mixing raw seawater with the contact seawater after oxidation, whereby the exhaust gas containing an acidic component is brought into gas-liquid contact with the seawater.

Abstract: In the embodiments described in the specification, a spark-ignited internal combustion engine has an exhaust line containing an oxide gas absorber for absorbing NOx and SOx and desorbing NOx and SOx at elevated temperatures. The support member for the oxide gas absorber is a metal foil or a thin walled ceramic support to permit rapid heating and is coated with a layer of a gas absorbing material at least 50 microns thick to permit longer intervals between regeneration, thereby providing effective storage of oxide gases even with fuel consumption-optimized engines.

Abstract: A method for introducing at least one gaseous reducing agent for a nitrogen oxide into a gas mixture, and a device for carrying out the method. Thermal energy is supplied to a body made from a starting material of the reducing agent, so as to form the reducing agent. The starting material used is urea. The reducing agent formed is ammonia. This method is used in particular to reduce nitrogen oxides in the exhaust gas from internal-combustion engines.

Abstract: An apparatus and process for removing acidic gases and NOx from flue gases produced by utility and industrial plants. The process and apparatus convert NOx, and particularly nitric oxide, to nitrogen dioxide, which is then reacted to form a valuable byproduct. The process generally entails contacting a flue gas with a scrubbing medium to absorb acidic gases from flue gas and produce an intermediate flue gas. The intermediate flue gas is then cooled to cause nitric oxide present therein to be oxidized to form nitrogen dioxide, which is then absorbed from the flue gases to produce a nitrogen dioxide-containing solution and a scrubbed flue gas. The nitrogen dioxide in the nitrogen dioxide-containing solution is then reacted with ammonium hydroxide to form ammonium nitrate as a valuable byproduct.

Abstract: The invention relates to a process for manufacturing hydrazine by hydrolyzing an azine, in which the heat required for the reaction and the separation by distillation of the components is partly provided by injecting vaporized water.

Abstract: A method of instantaneously forming a surface of an arc-treated material mainly including graphite into nano-tubes due to arc discharge carried out using a unit like a welding arc torch or the like without necessarily requiring a processing container, resulting in the nano-tube being applied to an electron emission source. A torch electrode acting as a first electrode and the arc-treated material made of graphite and acting as a second electrode are arranged opposite to each other. A potential is applied between both electrodes to generate arc discharge therebetween. A mask having an opening pattern is arranged on the arc-treated material, so that only graphite positioned on portions of a surface of the arc-treated material corresponding to openings of the mask are exposed to arc, to thereby be formed into nano-tubes.

Abstract: A method of synthesizing carbon nanotubes and a carbon nanotube synthesizing apparatus used for the same are provided. A catalyst is introduced into the reactor, and the catalyst in the reactor is selectively and locally heated by a heating method such as microwave irradiation, electromagnetic inductive heating, radio frequency heating or laser heating. Here, carbon source gas, carbon source gas and hydrogen sulfide gas, or carbon source gas and hydrogen gas or inert gas is supplied into the reactor, thereby growing carbon nanotubes from the locally heated catalyst.

Abstract: Methods to at least partially reduce a niobium oxide are described wherein the process includes heat treating the niobium oxide in the presence of a getter material and in an atmosphere which permits the transfer of oxygen atoms from the niobium oxide to the getter material, and for a sufficient time and at a sufficient temperature to form an oxygen reduced niobium oxide. Niobium oxides and/or suboxides are also described as well as capacitors containing anodes made from the niobium oxides and suboxides.

Abstract: A gas siphon type reactor (10) is used to carry out a three phase chemical reaction under pressure, such as the reduction of uranyl nitrate to uranous nitrate by hydrogen, in the presence of a catalyst made up of platinum on a silica carrier. The control of the pressure in the reactor (10) is provided by regulating the liquid and gas flow rates from a high pressure separator (52), into which the liquid and the gas leaving the reactor (10) are routed. The liquid in the reactor (10) is tapped from a lateral branch pipe (32) fitted with a filter (36) and emerging in the upper area (30), behind a profiled wall (34).

Abstract: Disclosed are methods for treating AVMs in a mammal by use of a radiation composition.

Abstract: The present invention relates to the delivery of rizatriptan or zolmitriptan through an inhalation route. Specifically, it relates to aerosols containing rizatriptan or zolmitriptan that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of rizatriptan or zolmitriptan. In a method aspect of the present invention, either rizatriptan or zolmitriptan is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of rizatriptan or zolmitriptan, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal.

Abstract: This invention relates to novel and improved bleach-stable compositions and processes and methods of making such compositions. More particularly, the invention relates to providing improved dental compositions comprising an effective amount of a discontinuous phase consisting of one or more hydrophobic, inert, bleach-stable abrasive agents that are polymers, copolymers and crosspolymers of granular nature of about between 2 microns and 150 microns particle size, present in the operative range of about 10% and 75% with respect to the total weight of the composition, said abrasive agents are dispersed or otherwise distributed in a continuous phase comprising one or more bleaching actives emulsed in an inclusion complex polymer (ICP) of delayed water and saliva solubility said emulsified bleaching active being capable of forming a long lasting bleaching film on tooth surfaces and being present in the operative range of about 0.

Abstract: This invention relates to a makeup containing a specific modified silicone obtained by an economical manufacturing method not requiring an esterification catalyst, having a high reaction rate and therefore leaving little unreacted material, and in particular relates to a makeup with good skin adhesion, good retention and excellent emulsion stability. A silicone compound represented by the general formula (1): R1aR2bSiO(4-a-b)/2 (in the formula, R1 is at least one substituent group having 1-30 carbon atoms, chosen from alkyaryl, aralkyl, fluorine-substituted alkyl or organopolysiloxanylsilyl, R2 is a carboxylate residue represented by the following general formula (2): R3 is a saturated or unsaturated hydrocarbon group having 2-30 carbon atoms, a is 1.0-2.5, and b is 0.001-1.5.

Abstract: Antiperspirant compositions for topical application are disclosed. These compositions show improved antiperspirant efficacy, while providing minimized skin residue as well as good skin feel when applied. These antiperspirant compositions comprise an effective amount of an antiperspirant active, from about 10% to about 60% of a topical carrier, and from about 0.5% to about 10% of a non-toxic, water-insoluble, occlusive film-forming polyester polymer.

Abstract: A cosmetic composition includes a carrier, a skin-whitening agent, and sodium magnesium silicate. The sodium magnesium silicate is present in an amount effective to slow decomposition of the composition. A method of slowing the decomposition of a cosmetic composition containing a skin-whitening agent includes adding an effective amount of a sodium magnesium silicate to the composition.

Abstract: A very low emission hybrid electric vehicle incorporating an integrated propulsion system which includes a hydrogen powered internal combustion engine, a metal hydride hydrogen storage unit, an electric motor, high specific power, high energy density nickel-metal hydride (NiMH) batteries, and preferably a regenerative braking system. The nickel-metal hydride battery module preferably has a peak power density in relation to energy density as defined by: P>1,375−15E, where P is greater than 600 watts/kilogram, where P is the peak power density as measured in Watts/kilogram and E is the energy density as measured in Watt-hours/kilogram.

Abstract: The invention relates to compositions and methods useful for preventing graft rejection in a recipient following organ transplantation.

Abstract: There is disclosed a fibrocyte-based vaccine formulations made from isolated fibrocytes. There is further disclosed a method for establishing an immune response against a specific antigen by administering a fibrocyte-based vaccine formulation, such as one made by pulsing fibrocytes in culture with the antigen peptide or protein, or by fusing tumor cells (whole cells or membrane fragments thereof) with fibrocytes.

Abstract: The present invention provides an isolated population of cells containing an expressible nucleic acid encoding proinsulin containing a proinsulin cleavage site and a glucose-regulated expressible nucleic acid encoding a protease capable of cleaving the proinsulin cleavage site to produce insulin. The invention also provides an isolated population of cells which further express a hexosamine synthetic pathway enzyme. The invention additionally provides vectors containing an expressible nucleic acid encoding proinsulin containing a proinsulin cleavage site and a glucose-regulated expressible nucleic acid encoding a protease capable of cleaving the proinsulin cleavage site to produce insulin. The invention further provides a method of treating or preventing diabetes by implanting into an individual cells coexpressing proinsulin containing a proinsulin cleavage site and a glucose-regulated protease capable of cleaving the proinsulin cleavage site to produce insulin.

Abstract: A method to follow the progression of metastasis of a primary tumor, which method comprises removing fresh organ tissues from a vertebrate subject which has been modified to contain tumor cells that express GFP and observing the excised tissues for the presence of fluorescence is disclosed. The fluorescence can also be monitored by observing the tissues in situ. Vertebrate subjects which contain GFP producing tumors are useful models to study the mechanism of metastasis, as well as to evaluate candidate protocols and drugs. In addition, subjects already harboring tumors can be treated so as to modify the endogenous tumors to contain GFP. This permits clinical applications. Finally, by injecting a contrast dye into a subject harboring a GFP-labeled tumor, angiogenesis in the tumor can be observed directly.

Abstract: This invention relates to the discovery that an intermediate, differentiated stage of pancreatic stem cells exist that can be propagated in a stable manner in successive serial passaging while maintaining insulin production in response to glucose. These cells are advantageous in that they are both expandable and stable in culture and can driven to late stage development, i.e. prototype islet cells. This invention further provides for culturing techniques that select for these intermediate differentiated stage cells and selectively eliminates early or late stage pancreatic cells.

Abstract: The present invention is directed to the production and use of custom tailored, bacterial enzyme mixtures or components thereof for degrading biofilms in both industrial and therapeutic applications. The industrial applications include but are not limited to the use biofilm-degrading, multiple specificity, hydrolytic enzyme mixtures for removing or preventing the formation of biofilms in water cooling towers, industrial process piping, heat exchangers, in food processing or food preparation, in potable water systems, reservoirs, swimming pools, or related sanitary water systems, and on membranes such as those used for desalinization, industrial processes, or related applications.

Abstract: The present invention is drawn to a method for treating autoimmune demyelinating diseases by administering to a patient in need thereof an effective amount of a Fas antagonist. The method of the present invention uses, for example, as a Fas antagonist a substance which suppresses Fas-Fas ligand binding.

Abstract: The present invention relates to the cross-linked scuPA/suPAR complex and/or tcuPA/suPAR cross-linked complex, the process of preparation of the covalently bound single compound having fibrinolytic activity and use of the cross-linked scuPA/suPAR or tcuPA/suPAR complex in the prevention and/or treatment of thrombolytic disorders. The invention further relates to combination compositions and/or therapy regimens, comprising the cross-linked scuPA/suPAR complex or tcuPA/suPAR and one or more currently used plasminogen activators to achieve improved therapeutic efficacy and/or reduce side effects.

Abstract: It is the objective and purpose of the present invention to provide a monoclonal antibody having the property of causing apoptosis on myeloid cells. This invention relates to a monoclonal antibody having the property of causing apoptosis on myeloid cells, and fragments thereof, and furthermore relates to a hybridoma producing the monoclonal antibody. Since the monoclonal antibodies of the present invention are useful as antibodies recognizing and identifying antigens causing apoptosis on myeloid cells specifically and besides have the property of causing apoptosis on myeloid cells, they may be used as medicine useful in the field of remedies for myelocytic leukemia utilizing the property.

Abstract: Vaccines, antibodies, proteins, DNAs and RNAs for diagnosis, prophylaxis, treatment and detection of Cryptosporidium species or Cryptosporidium species infections. Cryptosporidium species antigen and DNAs and RNA encoding the Cryptosporidium antigen and fragments thereof and recombinant proteins or fusion proteins produced thereby. Methods for diagnosis, prophylaxis, treatment and detection of Cryptosporidium species infections.

Abstract: Immunotherapy utilizing naked anti-granulocyte antibodies provides an effective means for treating chronic myelocytic leukemia (CML). Such antibodies can be administered alone or in combination with other therapies, such as immunoconjugates or chemotherapeutics. In either format, an effective therapy for treating CML is provided, which avoids the toxic side-effects typically associated with cancer therapy. The disclosed immunotherapy also is effective for treating acute myelocytic leukemia (AML) when co-administered with inducing agents which induce expression of antigens minimally displayed on the surface of myeloblasts.

Abstract: Isolated peptides that are fragments of protein products arising from frameshift mutations in genes associated with cancer are disclosed. The isolated peptides of the invention are capable of eliciting T cell immunity against cells harboring genes with such frameshift mutations. Cancer vaccines and therapeutically effective compositions containing the peptides of the invention are also described.

Abstract: Proteins with anti-angiogenic properties are disclosed, and methods of using those proteins to inhibit angiogenesis.

Abstract: DNA sequences encoding epitopes to which sporozoite-neutralizing antibodies are directed are provided. Recombinant proteins and synthetic peptides containing Cryptosporidium parvum epitopes for inducing an antigenic response are described.

Abstract: The invention concerns the field of pharmaceutics and dietetics. More particularly, the invention concerns pharmaceutical and/or dietetic mushroom-based compositions, characterised in that they contain one or several edible mushrooms with therapeutic properties and chitosan.

Abstract: Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions.

Abstract: The present invention consists of a cosmetic or dermatological composition comprising, in a physiologically acceptable medium: at least one alkynyl carbamate of formula (I) below:  in which: A denotes a halogen atom R denotes a hydrogen atom, an alkyl group, a hydroxyalkyl group, and at least one polyol chosen from non-etherified polyols, and (poly)alkyl or (poly)alkenyl polyol ethers; these polyols containing from 4 to 28 carbon atoms and from 2 to 6 hydroxyl functions, with the proviso that at least two of these hydroxyl functions are free; uses of these compositions and a cosmetic treatment process using these compositions.