Abstract: Molding material consisting of resin coated reinforcing fibers in a molten mass of resin and fibers is prepared at a molding site for controlled supply to a molding machine. A conveying device, such as a pair of pinch rollers, serves to pull fibers from supply spools through guide orifices of a coating die having a chamber within which the fiber is coated with molten resin. Further impregnation of the fibers with resin takes place in the conveying device, which also develops pressure on its output side serving to push the mass of hot resin and fiber into a receiving device for movement to a molding machine. The receiving device may be the feed screw for an injection molding machine or simply a plate movable to and from a compression molding machine. The fibers may be cut into predetermined lengths by a cutting device positioned downstream of the aforesaid conveying device.

Abstract: A process is provided for producing extruded honeycomb bodies with passages, in particular as catalyst carrier bodies for the cleaning of exhaust gas from an internal combustion engine. The passages are bounded by wall regions which are at least partly provided with structures. The honeycomb body is extruded with an extrusion die in such a way that an additional relative movement between the honeycomb body and the extrusion die takes place, leading to a deformation of the wall regions of the passages. An extrusion die for producing extruded honeycomb bodies includes a multiplicity of secured profiled pins and a housing, which together form an extrusion mask. The extrusion mask is variable during the production process, so that wall regions with the structures can be formed. Honeycomb bodies which have structures in the interior that are suitable for influencing a stream of fluid flowing through can therefore be produced in a manner which is simple in terms of production engineering.

Abstract: A hollow plastic product with a substantially tubular section, two open ends and a thread at the outside of one end of the product is manufactured by injection molding a plastic product with a substantially tubular section, an open end, a closed end and a thread at the outside of the closed end. An inner core of the core mold part is retracted from within the end of the mold cavity in which the thread is formed so that when the molded product is removed from the cavity mold part, the neck is compressed to partially occupy the region vacated upon removal of the inner core, whereby the thread is removed without damaging the thread. Removal of the molded product from the core mold part is at least helped by injecting compressed air into the closed end of the product. The closed end is then opened.

Abstract: A machine and method for moulding a composite of complex nodal structure includes laying down under CNC a reinforcement (38) of constant cross-section repeatedly into and along channels (26) of a mold (24) and through nodes of the structure, closing the mold, impregnating it with resin and curing the resin.

Abstract: A system and method for reinforcing at least a portion of a structural member, including at least one chamber or compartment having an interior portion which substantially conforms to the dimensions and geometry of the structural member being reinforced; and a reinforcement material for filling the interior portion of one or more of the compartments or chambers. The reinforcement material filling one or more of the compartments or chambers of the present invention can be a pumpable polymeric material, an heat activated expandable material, or a self-curing material. The compartment or chamber can be a polymeric material, such as nylon, which can be solid, blow-molded, flexible, or expandable depending upon the selected structural member to be reinforced.

Abstract: According to one embodiment of the invention, a system for packaging integrated circuits includes a mold tool for packaging integrated circuits. The mold tool includes a first mold plate that includes a first non-planar surface and a second mold plate that includes a second non-planar surface. The first and second non-planar surfaces form upper and lower surfaces of a mold cavity when the first and second mold plates are engaged. The mold tool also includes a distribution system coupled to the mold cavity. The distribution system transfers a mold compound into the mold cavity to substantially encapsulate an integrated circuit. The distribution system includes a gate runner coupled to the mold cavity. The gate runner funnels the mold compound into the mold cavity. The distribution system also includes a bridge insert that decreases wear on the gate runner as the mold compound is transferred through the gate runner.

Abstract: In an apparatus for manufacturing pressware containers from container blanks there is provided a plurality of inertial blank stop pins disposed so as to position a container blank prior to press forming. The stop pins are rotatable in order to absorb the kinetic energy of the container blanks as they are fed to the apparatus and eliminate blank bounce. In a further aspect of the invention there is provided a method of forming plates utilizing the improved apparatus including the inertial blank stop pins.

Abstract: A die comprises metal-rich sections which form an inner wall and an outer wall of the die, respectively. Gradient sections are disposed adjacent to the metal-rich sections, respectively. Further, a ceramics-rich section is disposed between the gradient sections. A punch comprises an inner ceramics-rich section, a gradient section, and an outer metal-rich section. In the die, the composition ratio of metal gradually decreases from the metal-rich sections to the ceramics-rich section. Similarly, in the punch, the composition ratio of the metal gradually decreases from the metal-rich section to the ceramics-rich section.

Abstract: A method of producing metal oxide nanoparticles in an exfoliated silicate framework by forming an aqueous exfoliated silicate suspension by mixing a layered clay into water until clear. To which is added an acidic hydrated metal species precursor solution, formed by dissolving one or more transitional metal salts, and a non-ionic surfactant. This solution is then aged to precipitate a product precursor before the product precursor is separated and washed. The product precursor is calcined to form metal oxide nanoparticles in an exfoliated silicate framework.

Abstract: A method and an apparatus for enhanced metallurgical processing of molten metal includes an enclosable ladle chamber (23) for reducing the escape of heat during transport of the ladle from a manufacturing vessel such as a furnace (13) to an intermediate processing (15) or refining station or during processing or transport to a receptacle vessel such as a tundish (17). The method comprises introducing a refractory body into the ladle chamber (23), the body having an adjusted specific gravity having a reduced steel ballast to refractory material ratio that is less than required for a specific gravity required to buoyantly support the body in the molten metal. Preferably, the ratio provides a specific gravity greater than the specific gravity required to buoyantly support the body entirely in the slag layer.

Abstract: An apparatus for producing a thixotropic metallic melt by simultaneously controlledly cooling and stirring the melt to form solid particles of a first phase suspended in a residual liquid second phase. Vigorous stirring of the metallic melt results in the formation of degenerate dendritic particles having substantially spheroidal shapes. The metallic melt is stirred to rapidly and efficiently circulate the forming semi-solid slurry. Circulation of the forming semi-solid slurry results in a substantially uniform temperature throughout. Through precision stirring and cooling, a semi-solid slurry is formed having a first solid phase of about 70–80 wt. % suspended in a second liquid phase.

Abstract: A method for densification of the surface layer of an optionally sintered powder metal component comprising the steps of decarburizing the surface layer for softening the surface layer of the component, and densifying the surface layer of the component.

Abstract: This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a three-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and/or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.

Abstract: An apparatus (1) which includes at least one planar surface (2) having compartments (3) which are defined by a partition (4), the compartments creating a space which makes it possible to displace at least one liquid sample (5 and/or 15) and, when there are at least two liquid samples (5 and 15), makes it possible to displace them both in an independent way and bring them together so that they can react with one another. The compartments (3) include at least two different types of groove: a deep groove (6), capable of partitioning the sample(s) (5 and/or 15), and a shallow groove capable of receiving the sample (s) (5 and/or 15), the two types of groove (6 and 16) making it possible to direct sample movements (5 and/or 15) by altering the orientation of the apparatus (1). The invention is particularly applicable for the micromanipulation of fluids in biological applications.

Abstract: A protein detecting device is disclosed. The device includes a reagent reservoir that is squeezable. The reagent reservoir has an end portion with a with a tubular member extending therefrom. This tubular member is hollow and in communication with the reservoir. The tubular member has an open end opposite the reservoir and has a cone shaped gasket in its open end. The cone shaped gasket has its base connected to an elongated member extending from the open end of the tubular member. The elongated member has a micro-brush at its end.

Abstract: The invention includes a heating apparatus for biological samples. The heating apparatus of the present invention includes a cover, a sample block having a plurality of openings in a top portion thereof for receiving a sample well tray having a plurality of sample wells, and an urging mechanism. The urging mechanism is positionable between the sample block and the sample well tray to urge the sample well tray away from the sample block when the cover is moved from a closed position toward an open position. The cover imparts a downward force on the top of the sample well tray to press the sample wells into the openings of the sample block when the heated cover is moved toward a closed position. The urging mechanism imparts an upward force on the sample well tray. The downward force imparted by the heated cover is sufficient to retain the sample well tray against the sample block when the cover is in the closed position.

Abstract: A random access reagent container handling system using a reagent container shuttle to move reagent containers between a loading tray and at least one linear reagent container tray and at least one circular reagent carousel. The reagent container tray is positioned as needed beneath the reagent container shuttle by a reagent tray shuttle.

Abstract: According to the present invention, there is provided an automatic chemical analyzer which is capable of conducting investigation of the influence of contamination regardless of the knowledge or technical skill of the user, and can prevent the occurrence of errors of determination by letting the user know that a problem has arisen in the function of inhibiting the generation of contamination. The combination of items which has been judged to involve contamination is extracted (step S7-1), and it is decided whether or not the result of judgement is the same as those of the previous judgements (step S7-2). In the step S7-2, if the results disagree, it is judged that trouble arises in the mechanism for preventing the generation of contamination, i.e., cleaning mechanism in this case, and an alarm of “trouble in cleaning mechanism” is given on the alarm display of a CRT.

Abstract: An electrochemical detection system which specifically detects selected nucleic acid segments is described. The system utilizes biological probes such as nucleic acid or peptide nucleic acid probes which are complementary to and specifically hybridize with selected nucleic acid segments in order to generate a measurable current when an amperometric potential is applied. The electrochemical signal can be quantified.

Abstract: A rapid method for assessing the bioequivalence of iron in iron-supplement formulations, particularly iron-sucrose formulations is described, which is based upon the kinetics of reduction of iron (III) to iron (II) in a sample of the formulation. Quality control methods and associated kits also are described.

Abstract: The invention relates to a rotary drive adapted for creating liquid flow in rotatable microfluidic discs. A rotary drive for spinning a disc shaped substrate having microfluidic structures formed therein for the flow control of microliter and/or nanoliter volumes of liquid by centrifugal force is suggested, comprising a motor with a spindle having an axis of rotation. A rotary member is connected for rotation with the spindle and driven for rotation relative to a stationary member, the rotary member being formed with a top plane having a centering guide for receiving the disc so as to force a symmetry axis of the disc into alignment with said axis of rotation. A vacuum source is connected with the stationary member and communicating with the rotary member or a part thereof rotating with the rotary member for applying sub-pressure to the disc when spinning the disc about its symmetry axis. Preferably, the rotary member is journalled for contact-free rotation relative to the stationary member.

Abstract: A pipette tip reloading system permits the reuse of a tip holder in a manner which interposes no additional transfer structure between the tip holder and the replacement tips. The reloading system includes a tip transfer tray and a push plate which releases the tips from the tray in a simple and reliable manner. The push plate also helps maintain alignment of the tips on the transfer tray as they are moved into position on the tip holder.

Abstract: A microplate liquid handling system requiring minimum installation area, helping to avoid waste of various reagents, and making it possible to perform dispensing the various reagents in the shortest possible time. The microplate liquid handling system has a main frame body provided with a moving mechanism, a dispensing mechanism, and a stage. On the stage, a microplate, two dispensing tip containers, and two reagent vessels are mounted. Formed in the microplate are 12×8 wells, i.e., 96 wells in total, arranged in matrix. The microplate, the dispensing tip containers, and the reagent vessels are substantially of the same, rectangular configuration. Each of the two dispensing tip containers is capable of accommodating 12×8 dispensing tips in total in a matrix fashion.

Abstract: A method of contaminant sequestering. Specifically, one embodiment of the present invention discloses an apparatus for sequestering a contaminant comprising an exothermically reactive structure disposed within a hermetic enclosure. A sorbent material coats a surface of the exothermically reactive structure. The sorbent material reacts with a contaminant contained within an atmosphere of the hermetic enclosure when exposed to heat from an exothermic alloying reaction in the exothermically reactive structure. As such, the contaminant becomes sequestered within the hermetic enclosure.

Abstract: A particulate filter regenerating device is configured to regenerate a particulate filter that collects particulate from engine exhaust gas. The particulate filter regenerating device is configured to prevent the temperature of the particulate filter from exceeding an allowable temperature during regeneration when the quantity of accumulated particulate is estimated to be lower than it actually is due to variation of the estimate. When the amount of temperature rise per unit time of the particulate filter is larger than a prescribed value during regeneration, it is determined that the temperature of the particulate filter will soon exceed the allowable temperature and the temperature rise amount ?Texh of the exhaust gas is reduced (?Texh1 is the normal temperature rise amount). The larger the temperature rise per unit time is, the more the temperature rise amount of the exhaust gas is reduced.

Abstract: A catalytic converter for an internal combustion engine exhaust system comprises a single-piece, seamless metal housing having tubulated gas inlet and outlet ports and a tubulated intermediate section with a catalytic element therein. The intermediate section is connected to the inlet port by an inlet transition section and to the outlet port by an outlet transition section. The inlet and outlet ports and the inlet and outlet transition sections are formed by swaging the ends of a seamless tube used to form the housing. Exhaust gas produced by operation of the engine passes into the converter and through the catalytic element. Noxious substances in the exhaust, including CO, NOx, and incompletely combusted hydrocarbons are converted to more benign substances through the action of the catalytic element, which is preferably a frangible ceramic honeycomb structure having a plurality of internal passages coated with a catalytically active substance.

Abstract: Methods and systems are configured to expose an object to an electrical discharge. The system includes a conveyor that conveys the object, a guide that guides the object, and an electrode that provides an electrical discharge. The guide is typically set to guide the object laterally with respect to the direction of the conveyor. The guide is generally used to place an object at a predetermined distance from the electrode. Also, the system may include multiple electrodes. The plural electrodes may be used to treat multiple sides of the object. Also, the electrodes may be positioned such that they are not coplanar with the conveyor. The system is suitably used to treat hollow objects which are in filling positions.

Abstract: A chemical reaction apparatus includes at least one reaction region formed on a solid body and having a continuously formed reaction flow path to which a fluid material is supplied, and a temperature adjusting layer which is provided on the body to correspond to a region including the reaction flow path and portions between adjacent portions of the reaction flow path. The temperature adjusting layer supplies a predetermined heat quantity to the reaction flow path.

Abstract: Enabling a transalkylation process to handle both C10 alkylaromatics and unextracted toluene permits the following improvements to be realized. No longer extracting toluene allows a reformate-splitter column to be eliminated. The extraction unit can be moved to the overhead of a benzene column and integrated together with the transalkylation unit to reduce costs. No longer requiring a rigorous split between C9 and C10 alkylaromatics allows a heavy aromatics column to be eliminated. Such an enabled transalkylation process requires stabilization of a transalkylation catalyst through the introduction of a metal function. These improvements result in an aromatics complex apparatus with savings on inside battery limits curve costs and an improvement on the return on investment in such a complex.

Abstract: A reprocessor for microbially deactivating items. The reprocessor has a circulation system for circulating a microbial deactivation fluid through a deactivation chamber that forms part of the circulation system. A container is provided for insertion into the deactivation chamber for holding items to be microbially deactivated. The container includes a tray and a lid. The tray and lid have interlocking, integrally formed, rigid seal elements formed thereon to form a seal between the tray and the lid.

Abstract: The present invention generally relates to the preparation of mixed actinide oxides, such as mixed oxides of uranium and plutonium (U, Pu) O2, by simultaneously coprecipitation and then calcinations.

Abstract: A method of treatment or purification of a molybdenum concentrate also containing copper, comprises the step of subjecting the molybdenum concentrate to pressure oxidation in the presence of oxygen and a feed solution containing copper (e.g. CuSO4) and halide (e.g. CuCl2) to produce a pressure oxidation solution containing copper and a solid residue containing molybdenum. The pressure oxidation solution may be combined with feed solution to a second pressure oxidation in which a copper concentrate is treated for the recovery of copper therefrom.

Abstract: A mechanism and technological process for synthesizing nano-sized crystalline hydroxyapatite.

Abstract: A tetracalcium phosphate (TTCP) particle for use in preparing a fast-setting, bioresorbable calcium phosphate cement is disclosed. The TTCP particle has a basic calcium phosphate whiskers on a surface thereof; the basic calcium phosphate whiskers having a Ca/P molar ratio greater than 1.33, and having a length up to about 5000 nm and a width up to about 500 nm. The basic calcium phosphate whiskers are substantially free of a hydroxyapatite phase and mainly composed of TTCP phase.

Abstract: A method of growing carbon nanotubes uses a synthesized mesoporous silica template with approximately cylindrical pores being formed therein. The surfaces of the pores are coated with a carbon nanotube precursor, and the template with the surfaces of the pores so-coated is then heated until the carbon nanotube precursor in each pore is converted to a carbon nanotube.

Abstract: Disclosed is a method of preparing treated metal oxide nanoparticles from sols prepared from metal alkoxides and organosilanes. The treated nanoparticles are useful high refractive index additives in the manufacture of optical articles.

Abstract: The present invention relates to a method for making hydrogen comprising contacting in a water-gas shift reaction zone a feed comprising carbon monoxide and water under water-gas shift conditions with an effective catalytic amount of a catalyst comprising highly dispersed gold on a sulfated zirconia, and collecting from the water-gas shift reaction zone an effluent comprising hydrogen and carbon dioxide. The invention also provides a catalyst composition and a method of making the catalyst. In a specific embodiment the invention provides a method for carrying out the water-gas shift reaction in the fuel processor associated with a fuel cell.

Abstract: One embodiment of the invention is a composition that comprises a radioactive [18F], [123I], [125I], or [131I]-N-radiohaloaryl-alkylcarboxamide molecule. The composition binds to the transient receptor potential-M8 (TRP-M8) receptor of cells. The TRP-M8 receptor is selectively expressed in sensory neurons and in malignant tissues such as prostate cancer cells. The [18F], [123I], [125I], or [131I]-N-radiohaloaryl-alkylcarboxamide ligand may be used for radioreceptor binding studies, for diagnostic studies, and for radiotherapy of cancerous tissues. Affinity of the [125I] or [131I]-N-radiohaloaryl-alkylcarboxamide ligand for the TRP-M8 receptor confers selectivity and specificity in delivering lethal radiation to the diseased cells.

Abstract: The present invention relates to the delivery of opioids through an inhalation route. Specifically, it relates to aerosols containing opioids that are used in inhalation therapy. In a method aspect of the present invention, an opioid is delivered to a patient through an inhalation route. The method comprises: a) heating a thin layer of an opioid, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% opioid degradation products. In a kit aspect of the present invention, a kit for delivering an opioid through an inhalation route is provided which comprises: a) a thin layer of an opioid and b) a device for dispensing said thin layer as a condensation aerosol.

Abstract: The cosmetic of the present invention is a cosmetic that alleviates skin irritation by blending in polypropylene glycol, a specific polar oil, or polybutylene glycol, as well as an ultraviolet absorbent. The present invention also relates to an agent and a method for alleviating irritation by lipophilic drugs. Since the present invention alleviates skin irritation due to ultraviolet absorbents and lipophilic drugs in cosmetics, any amount of ultraviolet absorbents and lipophilic drugs can be blended in cosmetics, and therefore cosmetics that can fully manifest their effects can be provided. Also, it is possible to prepare a safe sunblock cosmetic with superior ultraviolet protection effects because the ultraviolet absorbent is not absorbed through skin.

Abstract: A reshapable hair styling composition comprising, in a cosmetic vehicle appropriate for hair, at least one dispersion comprising at least one polyurethane in a water and/or solvent medium, said at least one polyurethane being obtained by reacting: (a) an isocyanate terminated polyurethane prepolymer being obtained by reacting: (i) at least one polyactive hydrogen compound insoluble in the medium of the dispersion, wherein said polyactive hydrogen compound is chosen from alkyl, aryl, and aralkyl structures optionally substituted in and/or on the structure by N, O, and/or S groups; (ii) at least one polyisocyanate, and (iii) at least one polyactive hydrogen compound soluble in the medium of the dispersion, (b) at least one polyfunctional chain extender; and (c) at least one chain terminator.

Abstract: A composition comprising, per liter of aqueous solution, from 30 to 350 g polyethylene glycol, from 3 to 20 g of an ascorbic acid component selected form the group consisting of ascorbic acid, a salt of ascorbic acid, or a mixture thereof, an alkali metal or alkaline earth metal sulphate, preferably from 1 to 15 g thereof, and optionally one or more electrolytes selected from sodium chloride, potassium chloride, and sodium hydrogen carbonate, and preferably also comprising flavorings, is effective in cleansing the gut in preparation for a endoscopy, especially colonoscopy. It is safer than conventional sodium phosphate-based gut cleansing compositions, and hence can be used for patients who would be at risk with sodium phosphate-based compositions, and is better tolerated than conventional PEG-based compositions, leading to better patient compliance and enabling effective out-patient use.

Abstract: A reconstructed epidermis/skin equivalent supplemented with at least one ceramide 7 and/or 5.5 compound, suited for reinforcing the barrier function of normal human epidermis and for improving the barrier function of dry skin and of reconstructed skin or skin equivalents, is prepared by introducing the at least one ceramide 7 and/or 5.5 compound into the culture medium of such reconstructed epidermis/skin equivalent and/or topically applying onto the face surface of such reconstructed epidermis/skin equivalent a composition which comprises lipid lamellar vesicles incorporating at least one ceramide 7 and/or 5.5 compound.

Abstract: The invention relates to surface display of proteins on micro-organisms via the targeting and anchoring of heterologous proteins to the outer surface of cells such as yeast, fungi, mammalian and plant cells, and bacteria. The invention provides a proteinaceous substance comprising a reactive group and at least one attaching peptide which comprises a stretch of amino acids having a sequence corresponding to at least a part of the consensus amino acid sequence listed in FIG. 10 and comprises a method for attaching a proteinaceous substance to the cell wall of a micro-organism comprising the use of said attaching peptide.

Abstract: The present invention relates to a new tumor suppressor, designated CAR-1, the gene for which is located on the short arm of human chromosome 1. This gene is directly implicated in colon, kidney and breast cancers, and the CAR-1 ubiquitous expression of the corresponding transcript suggests that it may be involved in yet others. Thus, one aspect of the invention is the diagnosis of CAR-1-related malignancies. The full length cDNA for CAR-1, as well as oligonucleotides derived therefrom, are disclosed. Screening methods for modulators of CAR-1 function and expression, as well as methods for cancer therapy, are described.

Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 and an amino acid solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 and the amino acid, such as carnitine, i.e., carnitine tartrate, in formulations, such as soft gel capsules.

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-? (TNF?) and are useful in vivo diagnosis and therapy of a number of TNF?-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract: The present invention relates to reagents which modify the activity of TWEAK and their use as therapeutic agents for the treatment of immunological disorders.

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-? (TNF?) and are useful in vivo diagnosis and therapy of a number of TNF?-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract: A CD154 binding molecule, in particular an antibody to human CD154, especially a human antibody to human CD154 is provided, wherein the CDRs of the heavy chain and light chain have amino acid sequences as defined, for use in the treatment and/or prevention of diseases or disorders wherein CD154 modulation and/or interference with or inhibition of the CD154:CD40 interactions is therapeutically beneficial.