Abstract: The invention relates to pharmaceutically stable nanoparticle formulations of poorly soluble drug substances, to the processes for the preparation of such formulations, and to methods of use thereof.

Abstract: Personal care composition comprising from about 0.1% to about 15% of an emulsifying silicone elastomer; from about 1% to about 90% of an aqueous phase; and from about 0.001% to about 5% of a coated particulate comprising a core material and a coating material, wherein the coated particulate has a size of from about 5 microns to about 100 microns and comprises from about 1% to about 15%, by weight of the coated particulate, of the coating material, and wherein the coating material comprises polysiloxanes.

Abstract: Disclosed are water-soluble nanoparticles. The water-soluble nanoparticles are each surrounded by a multifunctional group ligand including an adhesive region, a cross linking region, and a reactive region. In the water-soluble nanoparticles, the cross-linking region of the multifunctional group ligand is cross-linked with another cross-linking region of a neighboring multifunctional group ligand.

Abstract: This invention is accomplished by producing an effective composition for enteric coated medicine of mistletoe extract C) containing lectin and producing an effective composition for enteric coated microcapsule which has lectin as a major ingredient. The problem with oral administration due to unstability in the digestive system was solved and it enhanced drug efficiency, medical cure effectiveness contributing to medical industry.

Abstract: A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300 oC, and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.

Abstract: Process for a transplantable body part including extracting soluble materials therefrom, contacting the part with ozone, submerging the part in an inert body of liquid, contacting the part with nanoparticles coated with a growth factor or medicinal, and thereafter applying a pressure between 68,000 and 100,000 pounds per square inch to said body of liquid and part for a sufficient time to destroy microorganisms and affix the nanoparticles to the part. Also sterilized body parts with nonoparticles attached thereto, and body parts made by the foregoing processes.

Abstract: Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology and up to 20% of patients on dialysis have this diagnosis. A large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion channel protein Transient Receptor Potential Cation Channel 6. The missense mutation is a P112Q substitution, which occurs in a highly conserved region of the protein, enhances TRPC6-mediated calcium signals in response to agonists such as angiotensin II, and alters the intracellular distribution of TRPC6 protein. Previous work has emphasized the importance of cytoskeletal and structural proteins in proteinuric kidney diseases. Our findings suggest a novel mechanism for glomerular disease pathogenesis.

Abstract: The present invention provides polynucleotide molecules isolated from Oryza sativa and Zea mays and useful for expressing transgenes in plants. The present invention also provides expression constructs containing the polynucleotide molecules useful for expressing transgenes in plants. The present invention also provides transgenic plants and seeds containing the polynucleotide molecules useful for expressing transgenes in plants.

Abstract: The present invention relates to a nutritional supplement composition and methods for preparing. The invention further provides a method for creating a nutrient supplement drink composition comprising the a carrier liquid, a flower distillate, and at least one herbal extract component, and optionally including an additional ingredient selected from the group consisting of a second herbal extract component, a nutrient, a flavoring agent, a preservative, a coloring agent, a second carrier agent, and combinations thereof.

Abstract: The present invention relates to the use of pharmaceutically acceptable zinc salts, preferably water soluble zinc salts alone or optionally, in combination with one or more of a protein pump inhibitor (PPI), H2 blocker, anti-H. pylori antibiotic/antimicrobial, cytoprotective agent or a combination agent as otherwise described herein for providing fast action with optional long duration effect in reducing gastric acid secretion, raising the pH of the stomach during resting phase as well as decreasing the duration of stomach acid release during a secretagogue phase and for treating conditions including gastroesophageal reflux disease (GERD), non-erosive reflux disease (NERD), Zollinger-Ellison syndrome (ZE disease), ulcer disease, and gastric cancer, as well as preventing or reducing the likelihood of ulcer disease.

Abstract: The present invention provides methods and compositions for the treatment, diagnosis, prevention, or amelioration of one or more symptoms of a prolactin receptor-related condition, including, for example, a cancer such as breast cancer or prostate cancer, by administering a growth hormone-based prolactin receptor antagonist and zinc, or administering a growth hormone-based prolactin receptor antagonist to a tissue with an effective local concentration of zinc. The invention further provides pharmaceutical compositions of growth hormone-based prolactin receptor antagonists and zinc useful in the methods of the invention.

Abstract: The present invention relates to a nutraceutical composition for supporting body structures and functions in the upper digestive tract. The nutraceutical composition contains an effective amount of (a) an antioxidant having gastric proton pump inhibiting effects, (b an acid neutralizer; and (c) an antibacterial agent effective against Helicobacter pylori. This invention can be used as complimentary therapy with all acid reducing natural substances and pharmaceuticals. Its unique formulation compliments any attempts to reduce the damaging effects of gastric acid and reduce the damaging effects of H. pylori infection of the upper digestive tract.

Abstract: Solid Lipid Nanoparticles of platinum compounds, particularly of antitumor platinum complexes are disclosed. The Nanoparticles of the invention are obtained by a process comprising: a) preparing a first microemulsion by mixing a molten lipid, a surfactant, and optionally a co-surfactant and the platinum compound acqueous solution; b) preparing a solution by mixing a surfactant and optionally a co-surfactant in water, heating to complete solution, preferably at the same melting temperature of the lipid used in a) and adding a co-surfactant; c) dispersing the microemulsion obtained in a) into the solution obtained in b) obtaining a multiple microemulsion c); d) dispersing the microemulsion obtained in c) in aqueous medium at a temperature ranging from 0.5° C. to 4° C.

Abstract: An artificial physiological salt solution, wherein the active hydrogen reaction value is 0.01 to 1, the pH is 4.0 to 7.9 and the osmotic pressure is 260 mOsm/L to 2560 mOsm/L, as well as a manufacturing method for the same are provided as a novel artificial physiological salt solution, which has active oxygen eliminating activity and anti-inflammation effects, and can be appropriately used in a multitude of applications such as organ cleaning solutions (cleaning solutions for the eyes, cleaning solutions for the nose and the like), artificial infusions, artificial amniotic fluid, protective solutions, cell/tissue cultures and the like, as well as a manufacturing method for the same.

Abstract: The invention concerns a decontaminating composition having simultaneously bactericidal, fungicidal and virocidal properties, comprising as active components eugenol, eugenol acetate, vanillin and carvacrol, characterized in that said active constituents are present in the following percentages by weight: at least about 12% eugenol, at least about 3% eugenol acetate, at least about 0.1% vanillin and at least about 0.5% carvacrol. Said decontaminating composition can be used as liquid or solid soaps. It can also impregnate in liquid form fabrics and nonwoven fabrics such as garments for medical use, bed sheets, slip covers, surgery drape, dressings and gauze such as those applied to the skin of serious burn victims.

Abstract: The present invention relates to the use of a vitamin D compound active in up-regulating the expression and production of hCAP18 in humans for the manufacture of a medicament for treatment of conditions deficient in or benefiting from LL-37. The vitamin D active compound can be used as a medicament for treatment of injured tissues, chronic ulcers, burn wounds, skin infections and atopic dermatitis and for improving the microvasculature. UVB irradiation can also be used to up-regulate hCAP18.

Abstract: A bathing product for bathing comprises: a sodium hydrogen carbonate, commonly known as baking soda, being usable for softening the bathing water, removing body odor, revitalizing skin and facilitating enhanced body care or treatment, and a water sanitizing agent, being usable for effectively sanitizing the liquid and cleaning the bath apparatus without causing toxic effect to a bather for bathing in the liquid. The sodium hydrogen carbonate mixture may comprise 50-99% by weight sodium of hydrogen carbonate formed in powder form, and the water sanitizing agent may comprise about 1-10% by weight of trichloroisocyanuric acid.

Abstract: This invention encompasses an expeditious method and compositions that have been found to show selective cytotoxicity against several different cancer cell lines. for treating a wide variety cancer neoplasms that have tumor microenvironments by administering a stand-alone anti-tumor chemotherapeutic composition or administered as an adjunct with chemotherapy and/or radiotherapy with enhanced tumor site affinity that preferentially elevates the pH at the tumor site to suppress and eliminates the acidic tumor microenvironment, administered as chemosensitizing and/or radiosensitizers enhancing the tumor, suppression, remission and inhibit tumor metastisis. The invention encompasses controlling mechanisms of intracellular and extracellular ionic physiology through the administration of alkali salts for pH modulating and for restoring and enhancing ionic physiology.

Abstract: A device having a squeezable hollow member connected to a medication chamber in turn connected to a hollow tube fitted with an absorbent tip. The device may be used to conveniently administer a medication to an inflamed tissue. A method of providing a medication to an inflamed tissue is also provided.

Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.

Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.

Abstract: The present invention relates to an Nelumbinis semen extract having the effect of preventing or treating ischemic heart disease, as well as a pharmaceutical composition and health food for the prevention or treatment of ischemic heart diseases, which contain the Nelumbinis semen extract. The inventive Nelumbinis semen extract and the pharmaceutical composition and health food containing the same have the effect of recovering the heart which fails to function properly by ischemic heart diseases. Accordingly, they will be useful for the prevention or treatment of ischemic heart diseases, such as angina and myocardial infarction.

Abstract: A composition comprising a green tea extract (GTE) or its major component, (?)-epigallocatechin-3-gallate (EGCG). Also disclosed is a method of using the composition for keloid scar therapy.

Abstract: The present invention relates to pharmaceutical compositions having antiviral activity against Coronavirus, and more particularly against those viruses responsible for Severe Acute Respiratory Syndrome (SARS). In a preferred embodiment it comprises a total standardized extract of a Scutellariae spp.

Abstract: Pesticidal compositions containing rosemary oil and/or wintergreen oil and methods for using same are disclosed.

Abstract: A formulation designed to help sufferers of Irritable Bowel Syndrome who are prone to urgency symptoms. The formulation contains herbs, calcium carbonate, and food ingredients and the combination aids in management of the condition.

Abstract: A nutritional fiber derived from stabilized rice bran is described, as well as the use thereof for the prevention and treatment of several GI disorders, bowel disorders, as a laxative, in weight loss diets, as a therapeutic diet for reducing cholesterol and blood glucose levels, for dissolving and preventing kidney and gallstone formation, for cancer prevention and for cancer treatment.

Abstract: The present invention is directed to a sensate composition consisting of a liquid cooling composition, and at least one warming, tingling, or pungent sensate ingredient of either synthetic or natural origin which provides enhanced warming, tingling, or pungent properties. The liquid cooling sensate of the invention is a eutectic mixture of 2-Isopropyl-N,2,3-trimethylbutyramide and N-Ethyl-p-menthane-3-carboxamide, or at least one cooling agent selected from the group consisting of N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide, N-(3-ethoxypropyl)-2,3-dimethyl-2-isopropylbutanamide, N-(3-isopropoxypropyl)-2,3-dimethyl-2-isopropylbutanamide, N-(3-butoxypropyl)-2,3-dimethyl-2-isopropylbutanamide,N-Ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, N-(2-ethoxyethyl)-2,3-dimethyl-2-isopropylbutanamide and N-(3-methoxypropyl)-2,3-dimethyl-2-isopropylbutanamide.

Abstract: A method for the treatment, prophylaxis, amelioration or prevention of disorders associated with abnormally high activity of steroidal estrogens, which includes administering to a human subject a composition comprising an isoflavone-containing extract of clover or chick peas, said extract comprising primarily biochanin, or a ration of biochanin to one or more of the isoflavones from the group formononetin, daidzein and genistein in the range of from about 2:1 to about 5:1, optionally in association with one or more pharmaceutically acceptable carriers, excipients, auxiliaries and/or diluents is described. Also described are compositions and uses comprising the isoflavone containing extracts.

Abstract: The invention relates to a method of obtaining a firming active principle resulting from the solubilisation of Cucurbita pepo seed meal treated by means of enzymatic hydrolysis. The invention also relates to the active principle thus obtained and to the uses thereof in cosmetics.

Abstract: The invention relates to appetite-suppressing compositions obtained from botanical sources. More specifically, the invention relates to appetite-suppressing compositions comprising an extract product of an Asclepias plant, methods of making an appetite-suppressing composition, and methods of suppressing an appetite.

Abstract: Anti-malarial alkyloid compounds have the formula: wherein R1-R11 have various disclosed values or their pharmaceutically acceptable salts, and pharmaceutical compositions containing the same.

Abstract: The present invention relates to a method of manufacturing a stable composition enriched in cis-lycopene (z-isomers) by prolonged heating in solvents of tomatoes, parts of tomatoes, derivative thereof or tomato extracts in solvents.

Abstract: A cord sheathing device for one or more cords (F) with a plastic or thermoplastic material, comprising guiding means (2) for the cord(s) arranged at the inlet of the device and leading to a central chamber (51) connected by a duct to extrusion means that can deliver the said material under pressure in the viscous condition, an outlet die (4) of given calibration section S1 for the sheathed cord(s), and at least one mobile die (12) with calibration section S2 smaller than the calibration section S1. Each mobile die (12) is moved in the travel direction of the cord(s) F by an actuator (13, 15, 17), passing through the central chamber (51), and having a passage (14) allowing the central chamber (51) to communicate with the interior space of the mobile die (12).

Abstract: An injection molding machine configured so that items of molding conditions of which values are not changed can be set selectively when a set of molding conditions is read from a storage device so that values for the read molding condition items are set as the set values. Installation setting is established for the set items of those molding conditions of which set values are prohibited from being changed. When a set of predetermined values of the molding conditions is read from the storage device and set collectively, the set values for only those set items which are not designated to the installation setting are rewritten to the read values without changing the set values for the items designated to the installation setting. If a password with which the installation setting can be designated and canceled is entered, an installation setting mode is established, whereupon the installation setting for the set items can be designated or canceled.

Abstract: A plastic injection mold assembly is disclosed in which an electric servo motor very precisely controls rotational speeds and amounts of torque applied to cores which extend into the mold cavities as the cores are withdrawn from plastic components being molded and simultaneously directs the linear distances which the cores travel during such withdrawal. A method of accomplishing the molding of plastic components in this manner is also disclosed.

Abstract: A sensory system and method for optimizing the cycle time of a part-forming process, wherein the temperature status of a molded part is ascertained and utilized to enable minimization of mold close time.

Abstract: Device for producing a three-dimensional object by solidification of a material solidifiable under the action of electromagnetic radiation by means of energy input via an imaging unit comprising a predetermined number of discrete imaging elements (pixels), said device comprising a computer unit, an IC and/or a software implementation respectively with the ability of adjusting and/or controlling the energy input via a specific gray value and/or color value in a voxel matrix.

Abstract: The invention provides a manufacturing apparatus of a pellet which has not quality deterioration and a great apparent specific gravity. The apparatus is provided with (a) bunching portions (16) bunching band-like long continuous material(s) (R) and/or a plurality of filamentous long continuous materials (R) to a narrow width so as to form a cord-shaped bunched material (R?), (b) compressing portions (22) having compressing rollers (50a, 50b) with an uneven outer surface and form a cord (S) by point compressing a twisted cord material (R?), (c) rotation portions (14) twisting the cord-shaped bunched material (R?) by relatively rotating the bunching portions (16) or the compressing portions (22) so as to form the twisted cord material (R?), and (d) a cutting portion (102) provided in an outlet side of the compressing portion (22) and cutting the cord (S) formed by the point compressing to a pellet shape.

Abstract: A method of performing imprint lithography of a surface substrate includes a stamper having a thin lubricant coating thereon to facilitate release of the stamper from the imprinted surface to reduce degradation of image replication. Embodiments of the invention include stampers suitable for use in patterning servo information on magnetic recording media having a lubricant coating of from about 1 nm to about 20 nm.

Abstract: Blow molding tool arrangement is disclosed for an extrusion blow molding machine for plastic containers, especially for plastic bottles, comprising two or more blow mold parts (1, 2) which can be moved from an open into a closed position and vice versa and in the closed state border a mold cavity (7) which has at least one access opening (22) for a blow mandrel (8), and with at least one laterally movable ejection device (10) for removing from the mold a plastic tube which has been inflated by overpressure according to the mold cavity (7). The ejection device (10) is arranged such that it can be extended laterally relative to the inside wall of the mold during ejection and touches the plastic tubing upon ejection in a lost section (74) which is detached after removal from the mold.

Abstract: A sealing apparatus for sealing by resin a semiconductor wafer having semiconductor elements on its surface. The apparatus includes an upper mold and a lower mold having an area where the semiconductor wafer is mounted, the lower mold having an uneven surface in the area and a shock absorber under the lower mold.

Abstract: Discloses is: (i) a hot runner assembly of a molding system, (ii) a molding system including a hot runner assembly, (iii) a method of a molding system, and/or (iv) a mold of a molding system, amongst other things.

Abstract: The invention comprises a method for determining the least cost feed formulation for a ruminant animal, utilizing Rumen Active Feed Additives. Also described is a least cost feed formulation made through the use of the method, and use of the method to prepare a least cost feed formulation. Feed formulated for least cost and comprising various combinations of Rumen Active Feed Additives are also described.

Abstract: A diet system for promoting comprehensive weight management in companion animals. The diet system includes a stage I pet food product for promoting weight loss and building lean body mass and a stage II pet food product for maintaining the weight loss and the lean body mass.

Abstract: A fungal wild-type lipolytic enzyme having a higher ratio of activity on polar lipids compared with triglycerides, wherein the enzyme preferably has a phospholipid:triglyceride activity ratio of at least 4. Preferably, the lipolytic enzyme according to the present invention has a glycolipid:triglyceride hydrolyzing activity ratio of at least 1.5. In one embodiment, the fungal lipolytic enzyme according to the present invention comprises an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID No. 2 or SEQ ID No. 4 or SEQ ID No. 6 or an amino acid sequence which has at least 90% identity thereto. The present invention further encompasses a nucleic acid encoding a fungal lipolytic enzyme, which nucleic acid is selected from the group consisting of: (a) a nucleic acid comprising a nucleotide shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7; (b) a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No.

Abstract: The present inventions belong to the milk industry and can be used for producing pasteurized whole or restored milk and sour milk products on their basis, with a long-term storage time and improved organoleptic characteristics. The inventions provide more careful sterilization of milk and elimination of secondary contamination of products during all production stages thereof. The inventions consist in the method for producing sour milk products consisting in carrying out a milk treatment process and subsequent operations in the presence of soluble in milk derivative of polyphosphoric acid of general formula HO—[PO3X]n—PO3X2, wherein X represents sodium, or potassium, or calcium, or magnesium, or hydrogen or ammonium ions, and 30?n?1 at a quantitative value thereof ranging from 0.4 to 0.7 g/l; the milk treatment is carried out with double pasteurization, bottling and packing are associated with hermetic sealing at a temperature of 68-72° C.

Abstract: A method for making a liquid concentrate of food-grade acclimated and viable bacteria, preferably but not exclusively lactic acid bacteria.

Abstract: A system and method are described that provide a way to package food products. More specifically, a method of packaging food is described that provides an alternative to packaging food products with carbon monoxide. Instead, oxygen can be used during packaging in an attempt to preserve food product quality and color.

Abstract: A non-tea-based, packaged beverage with a green tea extract mixed therein contains the following ingredients (A) and (B): (A) 0.06 to 0.5 wt. % of non-polymer catechins, and (B) 9 to 13.5 mM of citric acid or a salt thereof. Its pH is from 3.4 to 4.2. The non-tea-based, packaged beverage contains catechins at a high concentration, is reduced in bitterness and astringency, is suited for long-term drinking, and is excellent in the stability of bitterness and astringency and also in the feeling as it passes down the throat, and moreover, its color tone remains stable over a long term even when packed in a clear package and stored at high temperatures.