Abstract: The present invention relates to novel processes for the preparation of substituted tetralin and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substituted indane derivatives.

Abstract: The invention relates to the use of a fatty acid for preparing a composition for allaying inflammatory reactions due to hypenoptera stings.

Abstract: Coated food products fortified with a polyunsaturated fatty acid, including sweetened food products, and methods for their preparation are provided.

Abstract: The invention relates to the use of selected (R)-2-[(halobenzyloxy)benzylamino]-propanamides and the pharmaceutically acceptable salts thereof for the manufacture of medicament, that are selectively active assodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, pain, migraine, periferal diseases, cardiovascular diseases, inflammatory processes affecting all body systems, disorders affecting skin and related tissues, disorders of the respiratory system, disorders of the immune and endocrinological systems, gastrointestinal, urogenital, metabolic and seizure disorders, where the above mechanisms have been described as playing a pathological role.

Abstract: Ophthalmic composition comprising one or more polyglycines selected from the group consisting of diglycine, triglycine, tetraglycine and pentaglycine, or the salts of each thereof and one or more boron buffering compounds. The ophthalmic composition will have an osmolality of from 200 mOsmol/kg to 420 mOsmol/kg.

Abstract: The present invention provides for a composition, kit and method for treatment of diseases, where the composition contains at least one catecholic butane, including NDGA compounds and derivatives, together with a pharmaceutically acceptable carrier that may include solubilizing agents or excipients, where the composition is suitable for injection into animals.

Abstract: The present invention concerns novel derivatives of 1-phenylalkanecarboxylic acids, pharmaceutical compositions thereof, a process for their preparation and their use for the treatment and/or prevention of neurodegenerative diseases such as Alzheimer' s disease.

Abstract: The present invention relates to specific N?-(menthanecarbonyl)amino acid amides of the formula (I): and mixtures thereof and to the use of the specific N?-(menthanecarbonyl)amino acid amides and mixtures thereof as physiological cooling active ingredients.

Abstract: A process for preparing nateglinide Form B comprises dissolving nateglinide in a solvent and adding the solution, at temperatures of 40-45° C., to a hydrocarbon liquid that is at temperatures of 40-45° C. Then, water is added and the mixture is allowed to cool, producing crystals of nateglinide Form B.

Abstract: Compounds that may be used for the treatment or prevention of a condition associated with T-cell proliferation or that is mediated by pro-inflammatory cytokines are of formula (I): wherein R1 is CHR4—OR5 or CHR4—SR5, or aryl or heteroaryl optionally substituted with one or more groups R6; R2 is alkyl or is part of a ring with R3; R3 is H, alkyl or CH2 (when forming part of a ring with R2); R4 is H or alkyl or is part of a ring with R5; R5 is aryl or heteroaryl optionally substituted with R7; each R6 is independently alkyl, CF3, OH, Oalkyl, OCOalkyl, CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHSO2alkyl, CONH2, SOMe, SO2NH2, Salkyl, CH2SO2alkyl or OCONalkyl2; R7 is R8 or (CH2)nOR8, R9, CF3, OH, OR9, OCOR9, COR9, COOR9, CONH2, CH2CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHCONHR7, NHCON(R9)2, NHCOR9, NHCOaryl, NHSO2Me, CONH2, SMe, SOMe Or SO2NH2; R8 is (CH2)nOR9, (CH2)nOR9, (CH2)nCOOR9 or (CH2)nCOaryl; R9 is alkyl or cycloalkyl; and n is 1 to 4; or a salt thereof.

Abstract: Pharmaceutical concentrate formulations comprising 2-amino-1,3-propanediol compounds, analogs thereof and salts thereof, particularly 2-amino-2-[2-(4-octylphenyl)ethyl]-propane-1,3-diol or a pharmaceutically acceptable salt thereof in an organic solvent or semi-aqueous solvent and methods for administration of the undiluted and diluted concentrate are provided.

Abstract: A series of Z-stilbenes derivatives are disclosed, which have the structure as shown by formula 1. In the structure of formula 1, X is hydrogen, NHR, or nitro group, and R is hydrogen. Y and Z is independently hydrogen, halogen, C1-C10 alkyl, or C1-C10 alkoxyl. Furthermore, A is hydrogen, hydroxyl, or amino group. The compounds of the present invention have both aqueous solubility and anti-tumor activity. The Z-stilbenes derivatives of the present invention can further include a pharmaceutical carrier to form pharmaceutical compositions as potent anti-mitotic agents and anti-cancer agents.

Abstract: Many metal chelators have polar or charged functional groups, which render them difficult to transport across a cell membrane. Polyamine-metal chelator conjugates of the invention are compounds comprising a first moiety which is a metal chelator and a second moiety which is a polyamine, where the polyamine moiety includes three or more nitrogen atoms which are capable of being positively charged at physiological pH. A spermine-L1 conjugate has been shown to accumulate in L1210 cells several hundred fold more than the unconjugated L1 chelator.

Abstract: Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers and degradation products thereof are non-toxic and typically have an LCST between room temperature and 37° C. so that they are liquid at room temperature and gelled at 37° C. which facilitates their use in humans, for example for wound treatment and as a cellular growth matrix or niche. The copolymer comprises numerous ester linkages in its backbone so that the copolymers are erodeable in situ. Degradation products of the polymer are soluble and non-toxic. The copolymer is amine-reactive so that it can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymer.

Abstract: A method of treating a spinal disk according to the present invention can include inserting an alloplastic bulking agent into the spinal disk to treat the defect. The alloplastic bulking agent has a plurality of microparticles. The bulking agent results in at least one of sealing the defect, increasing a pressure of the disk, increasing a height of the disk, improving stability of the disk and improving structural integrity of the disk.

Abstract: Biocompatible phase invertable proteinaceous compositions and methods for making and using the same are provided. The subject phase invertable compositions are prepared by combining a proteinaceous substrate and a cross-linker. The proteinaceous substrate includes one or more proteins and an adhesion modifier, and may also include one or more of: a pasticizer, a carbohydrate, or other modification agent. In certain embodiments, the cross-linker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.

Abstract: An ophthalmic solution comprising a hydrogen peroxide source in an amount sufficient to result in between about 0.001% and about 0.01% by weight stabilized hydrogen peroxide in said formulation as a preservative, one or more ocularly-compatible hydrogen peroxide stabilizers, hydroxypropylmethylcellulose and sodium carboxymethylcellulose, as well as pharmaceutical compositions comprising such solutions, are provided.

Abstract: Novel, stable aqueous coating dispersions of wax or combination of waxes are described. The composition apart from wax includes an emulsifier and a plasticizer. The pharmaceutical applications of the dispersion include taste masking, stabilization and release retardation of drugs.

Abstract: The present invention provides a method of reducing a level of a toxic protein in the cytosol of a cell, the method generally involving contacting the cell with an agent that induces a survival response by the cell. The present invention provides a method of reducing a level of a toxic protein in a cell, the method generally involving contacting the cell with an agent that induces sequestration of the toxic protein in an inclusion body in the cell. The present invention further provides methods of identifying an agent that induces sequestration of a toxic protein into an inclusion body. The present invention further provides methods of increasing the yield of a recombinant protein synthesized by a genetically modified prokaryotic or eukaryotic host cell.

Abstract: A novel TH2 associated gene that is induced by IL-9 has been identified and isolated, thereby providing a therapeutic target for IL-9 mediated diseases such as atopic allergy and asthma-related disorders. The invention also includes methods for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders, methods for diagnosing susceptibility to, and assessing treatment of atopic allergy or asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein. The use of this protein as a therapeutic agent for the treatment of autoimmune diseases is also indicated.

Abstract: The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer or prescribe bucindolol to a patient based on whether the patient is homozygous for the Arg 389 polymorphism in the ?1-adrenergic receptor (AR).

Abstract: Heavy oil emulsions, comprising decant oils and No. 6, No. 5 and No. 4 oils, and water are stabilized by adding certain saccharide-based esters. Preferably, the saccharide-based esters are naturally-occurring saccharide esters such as gallotannins, saponin, red gum, and the like.

Abstract: Aqueous dispersions of partly hydrophobic silica exhibit a smooth change in viscosity with pH over a wide pH range, without gelling or exhibiting local maxima. The dispersions have numerous uses, including use in O/W Pickering emulsions.

Abstract: The GTL process of the invention comprises: reacting a combustible carbonaceous material in a syngas reactor, preferably an autothermal reformer, under conditions to produce a synthesis gas; contacting the synthesis gas with an F-T catalyst to form liquid products and a tail gas; separating the tail gas from the liquid products; separating CO2 from the light products in the tail gas; recovering the light products as additional products for sale or other use and utilizing at least a portion of the separated CO2 as a feed stream to the syngas reactor.

Abstract: The invention relates to a process for preparation of anisotropic metallic nanoparticles comprising at least: a) One stage that is brought into contact with an aqueous solution that comprises at least one source of a metal that is selected from the columns 8, 9 or 10 of the periodic table and at least one soluble surfactant, b) One stage for formation of anisotropic metallic nanoparticles of at least one of said metals, by adding at least one reducing agent to the solution that is obtained in stage a), c) Said particles are: c1) separated from liquid and optionally dried, or c2) deposited on a substrate by impregnation with the suspension obtained in stage b) or after resuspension of the nanoparticles that are obtained at the end of stage c1), whereby the substrate is an oxide of unordered texture, and after separation of the possible residual liquid, the material that is obtained is dried at a temperature that is less than or equal to 120° C.

Abstract: The present invention relates to a method for the production of monodisperse pore-containing ion exchangers, and also of monodisperse pore-containing bead polymers having a particle size of 10-500 ?m.

Abstract: Expandable styrene polymer granules with halogen-free flame retardancy, comprising a) from 5 to 50% by weight of a filler selected from pulverulent inorganic substances such as talc, chalk, kaolin, aluminum hydroxide, aluminum nitrite, aluminum silicate, barium sulfate, calcium carbonate, titanium dioxide, calcium sulfate, silica, quartz flour, aerosil, alumina or wollastonite, and b) from 2 to 40% by weight of expandable graphite having a mean particle size in the range from 10 to 1000 ?m, c) from 0 to 20% by weight of red phosphorus or an organic or inorganic phosphate, phosphite or phosphonate, d) from 0 to 10% by weight of carbon black or graphite, and processes for their preparation and use for preparing self-extinguishing polystyrene particle foams.

Abstract: Expandable polystyrene foam compositions having flame retardant properties, flame retardant expanded polystyrene foams, methods of making such foams, and products comprising such compositions and foams are provided. A flame-retarded expanded polystyrene foam contains a flame retardant compound having the structure (I).

Abstract: Expandable polystyrene foam compositions having flame retardant properties, flame retardant expanded polystyrene foams, methods of making such foams, and products comprising such compositions and foams are provided. A flame-retarded expanded polystyrene foam contains a flame retardant compound having the structure: (I) wherein R is H or CH3.

Abstract: Expanded polystyrene coated with at least one organic pesticide, methods for making expanded polystyrene coated with at least one organic pesticide, and molded articles made from expanded polystyrene coated with at least one organic pesticide is provided herein.

Abstract: Extrudable polystyrene foam compositions having flame retardant properties, flame retardant extruded polystyrene foams, methods of making such foams, and products comprising such compositions and foams are provided.

Abstract: The present invention pertains to acid blocked, amine-based, autocatalytic polyols, and to the use of these autocatalytic polyols in the production of polyurethane foams having superior aging characteristics.

Abstract: The present invention relates to a polyisocyanate-based foam prepared in the presence of a blowing agent which comprises from 50 to 95 parts be weight 1,1,1,2-tetrafluoroethane (134a) and from 5 to 50 parts by weight of 1,1,1,3,3-pentafluoro-propane (245fa). Use of such a blowing agent composition provides for foam with a reduced smoke emission index.

Abstract: Prepolymers are prepared by a reaction of a polyisocyanate and a hydroxylmethyl containing polyester polyol derived from a fatty acid. The prepolymers can be prepared having isocyanate, hydroxyl, or a variety of other reactive functional groups. The prepolymers are useful in making polyurethanes and other polymers, or a crosslinking agents.

Abstract: The present invention is directed to silicone formulations which are capable of being rapidly cured to tough elastomeric materials through exposure to UV radiation, and optionally through exposure to moisture as well. The cured products demonstrate high resistance to flammability and combustibility.

Abstract: The present invention provides an amic acid ester oligomer with the structure of formula (1) wherein R, Rx, G, P and m are as defined in the specification. The present invention also provides a precursor composition for a polyimide resin comprising the above-mentioned oligomer of formula (1). The polyimide synthesized from the precursor composition exhibits good operations and physiochemical properties.

Abstract: A photo curable ink composition set, comprising: an ink composition A that includes at least a color material, a polymerizable compound, and a radical polymerization photoinitiator; and an ink composition B that includes at least a radical polymerizable compound and does not include the color material and the radical polymerization photoinitiator, wherein the ink composition A and/or B includes a sensitizer.

Abstract: This invention provides a novel pigment, which is used, for example, in color image display devices and can form a blue pixel capable of providing a high level of bright saturation, particularly a refined pigment, which has bright hue and is excellent in pigment properties such as lightfastness, solvent resistance and heat resistance, and a process for producing the same, a pigment dispersion using the pigment, and an ink for a color filter. The novel pigment is a subphthalocyanine pigment that is prepared by converting subphthalocyanine represented by general formula (1), in which X represents a halogen atom, to a pigment, has diffraction peaks at least at diffraction angles (2?) 7.0°, 12.3°, 20.4° and 23.4° in X-ray diffraction and an average particle diameter of 120 to 20 nm.

Abstract: A photosensitive resin composition for a flexible circuit board capable of suppressing warpage occurrence after heat curing, and a flexible circuit board obtained by using the same. The photosensitive resin composition includes (A) a carboxyl-group containing linear polymer having a glass transition temperature of not more than 55° C. obtained by addition polymerizing an ethylenic unsaturated compound; (B) a polymerizable compound containing an ethylenic unsaturated group; and (C) a photopolymerization initiator.

Abstract: A wound management fibre comprising a base fibre having a chitosan material associated therewith, characterised in that the wound management fibre has a significant proportion of chitosan associated therewith.

Abstract: Provided are a novel class of fumaric- and itaconic-containing prepolymers and compositions comprising the prepolymers used in the manufacture of medical devices.

Abstract: Disclosed herein is a method for preparing a food packaging film containing chitosan comprising 90.0 to 98.0% by weight of polyethylene resin and 2.0 to 10.0% by weight of a premix containing chitosan, in which the premix comprises fine flakes of polyethylene film and chitosan powder in a ratio of 80.0 to 99.5% by weight: 0.5 to 20.0% by weight. According to the method, in order to evenly disperse and distribute chitosan in the food packaging film, chitosan powder is previously mixed with synthetic resin film flakes to prepare a premix. The premix is mixed with a synthetic resin in a predetermined ratio and extruded to prepare the food packaging film. As a result, it is possible to industrially mass-produce the food packaging film, which has chitosan powder particles evenly dispersed and distributed therein and maintain excellent elongation and tensile strength.

Abstract: A roofing membrane comprising a polymer and an infrared reflective compound.

Abstract: The invention provides an ink composition for ink-jet printing which does not cause clogging of nozzles of an ink-jet printer during printing, to thereby provide a print of desired printing quality; which ensures an appropriate drying rate of printed images; and which attains excellent color development. The ink composition for ink-jet printing, containing a pigment, a binder resin, a pigment dispersant, and a solvent, wherein the solvent is formed of (1) at least one glycol ether and at least one of a lactone compound and 2-pyrrolidone, or (2) at least one glycol ether acetate and at least one of cyclohexane and isophorone.

Abstract: A marking liquid which contains a polymer dispersion with particles which are colored with marking agent, optionally further dyes and marking agents, one or more salts of a polyvalent, in particular bi- or trivalent cation, water and optionally moisture retaining agents and further usual additives, wherein the polymer forming the polymer particles is selected from the group of polyesters, polyester amides, polymers and copolymers based on acrylate or methacrylate with a proportion of free carboxylic acid groups of less than 10% by weight, melamine-formaldehyde-sulfonamide resins and mixtures thereof.

Abstract: Disclosed is a silicone impact modifier with a high refractive index. The silicone impact modifier can include (A) a rubber core including (a1) an organosiloxane cross-linked (co)polymer with a particle size of about 50 to about 400 nm and (a2) an alkylacrylate-styrenic aromatic compound cross-linked copolymer; and (B) a plastic shell including a vinyl (co)polymer. The refractive index of the silicone impact modifier of the present invention can be about 1.49 to about 1.59.

Abstract: To provide a flame retardant injection molded article that not only has flame-retardant properties but also combines impact resistance and heat resistance, either a flame retardant injection molded article is formed from a resin composition comprising a lactic acid resin (A), a metal hydroxide (B) whose surface has been treated with a silane coupling agent, and a copolymer (C) of lactic acid resin and diol/dicarboxylic acid, respectively at prescribed proportions, or a flame retardant injection molded article is formed from a resin composition comprising, in addition to the component (A) and component (B), either or both of an aliphatic polyester other than lactic acid resin and an aromatic aliphatic polyester (D), and an ester compound (E) of molecular weight in the range of 200 to 2,000, respectively at prescribed proportions.

Abstract: A method for producing an organic solvent dispersion of an intrinsically conductive polymer which comprises a step of deionizing an aqueous colloidal dispersion of an intrinsically conductive polymer by the passing of liquid, thereby clearing the intrinsically conductive polymer of cations adhering thereto, and a subsequent step of substituting water in the aqueous colloidal dispersion by an organic solvent. This method permits easy production of an organic solvent dispersion of an intrinsically conductive polymer which can be applied to various uses as electrode materials, antistatic agents, UV light absorbers, heat ray absorbers, electromagnetic wave absorbers, sensors, electrolyte for electrolytic capacitors, and electrodes for secondary batteries.

Abstract: The object of the invention is to provide a resin composition for semiconductor encapsulation realizing excellent soldering resistance and flame resistance and having excellent flowability and curing properties, and a semiconductor device. The invention has solved the object by a resin composition for semiconductor encapsulation comprising (A) an epoxy resin containing (a) an epoxy resin represented by formula (1), (B) a compound having two or more phenolic hydroxyl groups in its molecule, (C) an inorganic filler, and (D) a curing accelerator: wherein each of R1 and R2 represents a hydrogen atom or a hydrocarbon group with 4 or less carbon atoms and may be the same or different; and ‘n’ represents a mean value that is a positive number of from 0 to 5; in the formula (1).

Abstract: A thermoplastic composition is disclosed comprising a continuous phase of at least one thermoplastic polymer; and a non-polymeric precursor polymerizable to provide a polymerized reinforcing phase dispersed within the thermoplastic polymer. The precursor is polymerized after dispersion into the continuous phase of thermoplastic polymer. The flexural modulus of the thermoplastic polymer is thereby increased. Methods of making and using the composition are also disclosed.