Abstract: Catechol protected levodopa diester prodrugs pharmaceutical, compositions comprising catechol protected levodopa diester prodrugs, and methods of using such prodrugs and pharmaceutical compositions for treating diseases such as Parkinson's disease are provided.

Abstract: A pharmacological compound characterized by the conjugation of a fatty acid such as butyric, caproic, caprylic, lauric, myristic, palmitic, stearic, arachidic, behenic, oleic, linoleic, alpha-linolenic, arachidonic, eicosapentaenoic, docosahexaenoic acid, euric acid with Hyodeoxycholic acid or other systemic biocompatible lipid solubilizer/detergent compounds, as opposed to biocompatible lipid solubilizers/detergents sequestered in the entero-hepatic circulation, said conjugated compound being capable of producing a sustained bioavailability in the systemic circulation to access atherosclerotic plaques and cause ubiquitous dissolution of the cholesterol crystals and of the other cholesterol/lipids aggregations forming the lipidic component of an atherosclerotic plaque and also the ubiquitous dissolution of adipose tissue.

Abstract: Methods and compositions for assisting in human weight loss. In a preferred embodiment, the administration of branched-chain amino acids and fatty acids to a subject at a level that provides approximately a two and a half percent (2.5%) reduction in weight over a one-week period.

Abstract: A highly concentrated preparation of sodium 4-phenylbutyrate in an aqueous medium as an alternative for present high dosage therapeutic treatments of certain disorders is provided, specifically for the treatment of spinal muscular atrophy (SMA), central nervous system (CNS) cancer, myelodysplastic syndrome (MS), acute leukemia, glioblastoma multiforme, amyotrophic lateral sclerosis (ALS), and colon cancer.

Abstract: Provided herein are bioactive agents comprising a compound that inhibits the ion transport activity of a cystic fibrosis transmembrane conductance regulator (CFTR) and that is linked to a macromolecule that interacts with a cell that expresses CFTR. The bioactive agents described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, secretory diarrhea.

Abstract: The present invention relates to a humectant composition containing, as component (A), at least one member selected from a menthol derivative represented by the following formula (1) and p-menthane-3,8-diol: in which R is an alkylene group having 2 to 5 carbon atoms which may be substituted with at least one member selected from the group consisting of a methyl group and a hydroxyl group, and n is an integer of 1 to 3. The humectant composition of the present invention provides an excellent moisture-retention effect.

Abstract: The present invention is related to the development of a novel inter and intra multilamellar vesicular composition containing an antipsoriatic drug dithranol. The exquisitely structured mesophase made up of saturated phospholipids (which have an inherent antioxidant property and protect the lipid soluble molecules) at the micro range level improve the overall performance of the drug by way of modifying and controlling the release as well as the reactivity of the drug. Further, such microstructured system in conjunction with hydrocolloid gel makes the system rheologically more acceptable. Thus, the formulation so developed tends to make the drug molecules effective at a reduced dose level, non-irritant, non-staining, easily applicable (stays on the affected site) and stable as well. Besides this, there is an added advantage allowing an enhanced application time vis-ô-vis the short contact therapy presently practiced.

Abstract: The present invention is directed to novel compounds of the structure and a method for enhancing a perfume composition by incorporating an olfactory acceptable amount of the compounds provided above.

Abstract: The present invention provides methods for identifying agents that modulate a level or an activity of a mitochondrial NAD-dependent deacetylase polypeptide, as well as agents identified by the methods. The invention further provides methods of modulating mitochondrial NAD-dependent deacetylase activity in a cell. The invention further provides methods of modulating mitochondrial function by modulating the activity of mitochondrial NAD-dependent deacetylase.

Abstract: The invention relates to application of benzimidazole-substituted polybenizimidazole polymers as initial material for preparing proton-conductive membranes, preferably used in high-temperature fuel cells. Detail methods are provided, comprising the steps of obtaining the polymers, preparing film containing the polymer, doping the film with predetermined acid, thereby forming a proton-conductive membrane with improved proton conductivity. Particularly, a group consisting of three types of the polymers is described. In a preferred embodiment, the predetermined acid is being phosphoric acid.

Abstract: A process for synthesizing polymer foam. Polymer foams can be created through the direct mixing of chemicals. Prior research has shown that greater uniformity can be created by physically mixing the components of the foam before and during the foaming process. This invention covers the creation of polymer foam utilizing the mixing energy created by sound waves (herein referred to as sonication) prior to and during the foaming process. The result of physical mixing through sonication is a more uniform foam.

Abstract: The invention relates to a flame-retardant resin formulation comprising respectively at least one flame-retardant component, one alkali-soluble component, one polymerizable monomer, one photoinitiator, and one epoxy component, which comprises, as flame-retardant component, a phosphinic salt of the formula (I), in which R1 and R2 are identical or different and, independently of one another, are C1-C6-alkyl, linear or branched, and/or aryl; M is Mg, Ca, Al, Sb, Sn, Ge, Ti, Zn, Fe, Zr, Ce, Bi, Sr, Mn, Li, Na, K, and/or a protonated nitrogen base, and m is from 1 to 4. This novel flame-retardant resin formulation is preferably used as solder resist.

Abstract: The invention is directed to a thick film getter composition comprising: (a) desiccant material; dispersed in (b) organic medium comprising (1) curable organic polymeric binder; (2) monomer; and (3) photoinitiator.

Abstract: Unique photoprotective compositions contain novel methyltrialkylsilanes bearing a cinnamate, cinnamamide, benzalmalonamide or benzalmalonate function, useful as sunscreens that are active in the field of UV radiation and also useful in methods for photostabilizing synthetic polymers or glasses.

Abstract: A pathogen-resistant coating comprising one or more photocatalysts capable of generating singlet oxygen from ambient air. The pathogen-resistant coating may optionally include one or more singlet oxygen traps.

Abstract: This invention relates to latex compositions that incorporate at least one bioactive component such as an antibacterial or an antifungal agent, and methods for making and using such latex compositions. The latex compositions disclosed herein can be prepared by the emulsion polymerization of the latex component monomers in the presence of the at least one bioactive component.

Abstract: This invention concerns a product that waterproofs and reduces the spread of fire. Comprising of at least a first component and a second component. The first component comprising of at least an always flexible elastomer; The second component comprises of at least a cement, where the said waterproofing product comprises also of at least a third component this being flame retardant.

Abstract: Exemplary embodiments of the cement compositions comprise water, a cement, and a fluid loss control additive, the fluid loss control additive comprising a graft copolymer. The graft copolymer comprises a backbone and at least four grafted monomers selected from the group consisting of 2-acrylamido-2-methylpropanesulfonic acid, acrylamide, acrylic acid, vinylphosphonic acid, diallyldimethylammonium chloride, and salts thereof. The backbone of the graft copolymer comprises a humic acid salt. Methods of cementing using exemplary embodiments of the cement compositions are also provided.

Abstract: A two-component reaction resin includes a resin component (A), which contains, as curable constituent (a), at least one free radical-curable, ethylenically unsaturated compound, an agent (b) for adjusting the reactivity and the gel time and at least one comonomer (c) and a curing component (B), which is disposed separate therefrom to inhibit any reaction and is a curing agent for the resin of the resin component (A) and which, as agent (b) for adjusting the reactivity and the gel time, contains a pyrocatechol derivative of the general Formula (I):

Abstract: A method for forming an interlayer having improved solar control properties is disclosed. The method includes: a) forming a polymer material from a reaction mixture; b) adding one or more solar control components to the reaction mixture while the polymer material is being formed; and c) curing the reaction mixture.

Abstract: An article of footwear includes an upper and a sole assembly secured to the upper. The sole assembly includes a lower ground engaging surface portion and an upper surface portion. The upper surface of the first portion is in contact with the upper. At least part of the lower ground engaging surface portion is a polymer material formed from a blend of polybutadiene polymer and a carboxylated butadiene-acrylonitrile or partially hydrogenated carboxylated butadiene acrylonitrile; wherein the polymer material has a density of 1.00-1.25 g/cm3 and a hardness of at least 55 Asker C.

Abstract: The present invention provides fast-drying aqueous compositions that lower the cost of making roadway markings without impairing the quality or appearance of the markings made therewith. The aqueous compositions comprise one or more hollow core binder having an average particle size of from 200 to 500 nanometers (nm), preferably from 300 to 470 nm, and made of a first polymer having a glass transition temperature (Tg) of 50° C. or more and containing one or more void, the first polymer being substantially encapsulated by one or more second polymer having a Tg of ?30° C. or more, preferably, ?20° C. or more. Fast-drying aqueous compositions may be one component or two component compositions.

Abstract: In a particular embodiment, a particulate material includes alumina hydrate. The particulate material has a 500 psi Compaction Volume Ratio of at least about 4.0 cc/cc.

Abstract: The invention provides a non-efflorescing cementitious mortar composition, free of reactive silica material, in the form of a dry-mortar composition or an aqueous mortar composition, comprising a) ordinary portland cement, b) calcium aluminate cement, c) calcium sulfate, and d) an aqueous polymer dispersion or a water-redispersible polymer powder of polymers based on one or more monomers from the group consisting of vinyl esters, (meth)acrylates, vinyl aromatics, olefins, 1,3-dienes and vinyl halides and, if required, further monomers copolymerizable therewith.

Abstract: An admixture formulation of at least one polycarboxylate dispersant and at least one naphthalene dispersant is provided. When the polycarboxylate dispersant and the naphthalene dispersant of the admixture formulation are combined at various ratios the admixture formulation reduces the tendency for bleed and segregation in cementitious mixtures without increasing water demand, retarding setting, increasing water sensitivity, promoting high viscosity, or reducing flow retention.

Abstract: An alpha-halocarbo aromatic monomer or comonomer and/or an allyl halide monomer or comonomer can be reacted with aluminum or an aluminum-containing catalyst to form a polymer.

Abstract: A pigmented inkjet ink comprising a pigment and a polymeric dispersant wherein the polymeric dispersant is a statistical copolymer comprising between 3 and 11 mol % of a long aliphatic chain (meth)acrylate wherein the long aliphatic chain contains at least 10 carbon atoms.

Abstract: The invention relates to low-viscosity polyaddition compounds containing uretdione groups, preparation process, and use.

Abstract: A curable composition includes a functionalized poly(arylene ether), a vinyl thermoset resin, and a flame retardant composition. The flame retardant composition includes a trihydrocarbylphosphine oxide and a nitrogen-containing flame retardant that may be melamine phosphate, melamine pyrophosphate, or melamine polyphosphate. The combination of the trihydrocarbylphosphine oxide and the nitrogen-containing flame retardant is particularly effective at improving the flame retardancy of the cured composition at relatively low levels of total flame retardant. A method of preparing the curable composition and articles including the cured composition are also described.

Abstract: A treated pigment comprising: (a) an inorganic pigment; (b) an organic compound comprises a fluoroalkyl group and a hydrocarbon group and having the structure: RH-L-RF, wherein RF is a fluorochemical component containing at least one Zerewitinoff hydrogen; RH is an aliphatic group of 1-30 carbons, cycloaliphatic group of 3-30 carbons, an aromatic group of 6-30 carbons, or a group having the structure: R?—(OCH2CHR?)x?—(OCH2CH2)y?—O—, wherein R? is H or an aliphatic group of 1-20 carbons, R? is H or methyl; and x? and y? are the same or different integers ranging from 0-20 except that the sum of x? and y? is at least 1 when R? is H; and L is selected from the group CO, isocyanate, and a mixture of polyisocyanates containing at least three isocyanate groups per RH-L-RF structure. Plastic articles containing a pigment and the organic compound have improved cleanability with all the other needed properties and without the negative property of chaulking.

Abstract: The invention is a polymer composition and a method of preparing same, wherein the polymer composition comprises at least one perchlorate and at least one organic solvent. The polymer composition is preferably for use with halogen-containing polymers.

Abstract: Latex-based compositions, and methods of forming the same, that are useful to dampen noise and vibrations, are disclosed. The compositions can be applied to and adhered to a substrate. The compositions comprise latex and at least one filler. The compositions form microcracks during drying and/or curing to aid in the removal of water from the compositions.

Abstract: A thermoplastic vulcanizate comprising a dynamically-cured rubber, where the rubber is selected from the group consisting of ethylene-propylene-non-conjugated diene rubber, propylene-based rubbery copolymers with units derived from non-conjugated diene monomers, butyl rubber and styrene-butadiene rubber, where dynamic vulcanization is effected with a phenolic resin or a silicon-containing curative, and where the rubber is dynamically cured to an extent where greater than 94% by weight of the rubber is insoluble in cyclohexane at 23° C., and from about 25 to about 250 parts by weight of a thermoplastic polymer phase per 100 parts by weight rubber, where about 85% to about 50% by weight of the thermoplastic polymer phase includes a propylene-based polymer, and where from about 15% to about 50% by weight of the thermoplastic polymer phase includes a butene-1-based polymer.

Abstract: A thermoplastic vulcanizate comprising a dynamically-cured rubber, where the rubber is selected from the group consisting of ethylene-propylene-non-conjugated diene rubber, propylene-based rubbery copolymers with units derived from non-conjugated diene monomers, and butyl rubber, where dynamic vulcanization is effected with a phenolic resin or a silicon-containing curative, and where the rubber is dynamically cured to an extent where greater than 94% by weight of the rubber is insoluble in cyclohexane at 23° C., and from about 25 to about 250 parts by weight of a thermoplastic polymer phase per 100 parts by weight rubber, where from about 75% to about 100% by weight of said thermoplastic polymer phase includes a butene-1-based polymer.

Abstract: The invention is directed to a flame retardant additive comprising carbon based nanotudes having flame retardant properties. The flame retardant additive of the invention includes up to about 25% by weight of the carbon-based nanotube. An embodiment of the invention is directed to a polymer including the flame retardant additive of the invention which comprises an effective amount of carbon based nanotubes. The invention also relates to a method of improving the flame retardant properties of a material, the method including adding to the material an effective amount of the flame retardant additive of the invention.

Abstract: Polymers are filled with from 1 to 8% by weight of an expanded graphite having a BET surface area of at least 120 m2/g. Processes for preparing such polymers include forming a dispersion of the expanded graphite in a polymerizable monomer or curable polymer precursor, and polymerizing or curing same in the presence of the expanded graphite. Electroconductive polymers can be prepared in this manner using low levels of the expanded graphite material.

Abstract: The present invention is a composition useful for coating the surface of paper wherein the coating composition is an aqueous solution comprising less than 40 wt % water and consisting essentially of a polyvinyl alcohol copolymer that is at least about 95% hydrolyzed, and a process for preparing the same.

Abstract: An adhesion promoter for a hot melt adhesive or a pressure sensitive adhesive prepared by admixing a hydrolytic silane compound with an aqueous buffer solution. The adhesive is able to bind at very low surface free energy substrates, such as Xerographic prints contaminated by silicone fuser oil. The hot melt adhesive maintains a substantially stable viscosity at temperature ranging from about 100° C. to about 200° C.

Abstract: An amine-containing alkoxysilyl-functionalized polymer, a method of preparing a reactive polymer functionalized with an alkoxysilane functionalizing agent and further reacted with an amino alcohol, the resulting polymer, and vulcanizates thereof.

Abstract: The present invention is a, solid block copolymer comprising at least two polymer end blocks A and at least one polymer interior block B wherein each A block is a polymer block resistant to lithiation and each B block is a polymer block susceptible to lithiation, and wherein said A and B blocks do not contain any significant levels of olefinic unsaturation.

Abstract: A method of making a polyether-polydialkylsiloxane block copolymer is provided. The method comprises providing a mixture comprising at least one alkylene oxide and at least one silanol-terminated polydialkylsiloxane; and polymerizing the mixture in the presence of a double metal cyanide complex catalyst, and optionally in the presence of an aprotic solvent and/or an antioxidant. A polyether-polydialkylsiloxane block copolymer having a molecular weight of 150-50,000 g/mole and having a polydispersity index of 1.0 to 1.5 made by the above method is also provided.

Abstract: The present invention relates to adhesives comprising at least one silicon-comprising copolymer of C1-C20-alkyl (meth)acrylates and at least one ethylenically unsaturated acid anhydride or one ethylenically unsaturated dicarboxylic acid whose carboxyl groups can form an anhydride group, or mixtures thereof, or at least one monomer comprising an isocyanate group and capable of free radical copolymerization.

Abstract: A water dispersible polyurethane composition comprising polyol component (a), polyisocyanate component (b), ionic group-introducing component (c), ionic group neutralizer (d) and water as essential components, wherein a both-end hydroxylated vinyl ether compound represented by general formula (I) is used as polyol component (a). (In the formula, R represents an alkyl group having 1 to 4 carbon atoms and n is a number of 1 to 100.

Abstract: The invention relates to aqueous polyurethane dispersions comprising diphenyl-methane 2,2?-diisocyanate as a synthesis component, to a process for preparing them and to use as coating compositions.

Abstract: Ring opening products of epoxides with fatty acid methyl esters with alkanols or water are eminently suitable as viscosity adjusters for high-viscosity polyols.

Abstract: Certain thermoplastic additives that induce simultaneous good material properties and high nucleation efficacy are provided. Such additives include combinations of a phosphate salt and a dicarboxylate salt. This combination or blend may be provided in various ratios. A method for applying such a combination in a thermoplastic formulation is also disclosed. A thermoplastic formulation, which may or may not include polypropylene, is also disclosed in connection with the nucleating agent blend combination.

Abstract: A sulfonation method to treat a polymer substrate to provide a hydrophilic layer with an improvement in at least one of anti-fogging, anti-static, wettability, lubricity, anti-microbial and/or transparency properties. The articles formed thereby find excellent application in a wide range of areas.

Abstract: Synthesis methods for creating polymeric compounds comprising dihydroxyphenyl derivatives (DHPD), or DHPp i.e. polymers modified with DHPD, with desired surface active effects are described. The polymer backbone of DHPp has structural or performance features that can be tailored to control physical properties of DHPp, allowing it to be useful for different applications i.e. tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.

Abstract: Disclosed is a process for postcrosslinking a water absorbing polymer by the polymer being treated with at least one postcrosslinker and postcrosslinked and dried during or after the treatment by raising the temperature, the at least one postcrosslinker being a cyclic carbamate or a cyclic urea, wherein the cyclic carbamate or the cyclic urea was obtained by reacting respectively an aminoalcohol or a diamine with a cyclic carbonate.

Abstract: The present invention relates to a polymerization process for producing olefin polymers in a loop reactor comprising two or more settling legs, comprising the steps of: —introducing into the loop reactor one or more olefin reactants, polymerization catalysts and diluents, and while circulating said reactants, catalysts and diluents; —polymerizing said one or more olefin reactants to produce a polymer slurry comprising essentially liquid diluent and solid olefin polymer particles; said process further comprising one or more cycles of: (a) allowing said polymer slurry to settle into said setting legs, and (b) sequentially discharging said settled polymer slurry from said two or more settling legs out of the reactor, whereby the aggregate time of discharge of all the legs is more than 50%, preferentially more than 80% and most preferably more than 95% of the time interval between two triggerings of the same settling leg.