Patents Issued in December 1, 2009
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Patent number: 7625823Abstract: In a method of manufacturing a metal pattern, a metal layer is deposited on a passivation layer, and a photoresist pattern is then formed on the metal layer. Using the photoresist pattern as a mask, an exposed portion of the metal layer is treated with a plasma to lower a binding force in the metal. The metal layer is then etched to form a the metal pattern. The method is applicable to the formation of pixel electrodes in LCD devices.Type: GrantFiled: August 25, 2000Date of Patent: December 1, 2009Assignee: LG Display Co., Ltd.Inventor: Kwang-Jo Hwang
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Patent number: 7625824Abstract: The present invention provides a method for creating a process change detection algorithm. An evolutionary computing technique is applied to at least one process dataset containing at least one known process change. The evolutionary computing technique will generate a process state function (or a scaling coefficient set for use with an existing process state function) that optimizes detection of the known process changes. The generated process state function or coefficients can then be applied thereafter to future datasets (either in real-time or after processing) to detect process changes.Type: GrantFiled: May 26, 2006Date of Patent: December 1, 2009Assignee: Oerlikon USA, Inc.Inventor: Jason Plumhoff
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Patent number: 7625825Abstract: A method of making a microelectromechanical system (MEMS) device is disclosed. The method includes forming a stationary layer over a substrate. A sacrificial layer is formed over the stationary layer. The sacrificial layer is formed of a first material. A mechanical layer is formed over the sacrificial layer. A hard mask layer is formed over the mechanical layer. The hard mask layer is formed of a second material. The first and second materials are etchable by a single etchant which is substantially selective for etching the first and second materials relative to the mechanical layer. The hard mask layer is patterned after forming the hard mask layer. Subsequently, the mechanical layer is etched through the patterned hard mask layer. The patterned hard mask layer is removed simultaneously with the sacrificial layer after etching the mechanical layer.Type: GrantFiled: June 14, 2007Date of Patent: December 1, 2009Assignee: QUALCOMM MEMS Technologies, Inc.Inventor: Wen-Sheng Chan
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Patent number: 7625826Abstract: The invention relates to a method of manufacturing a semiconductor device (10) with a substrate (1) and a semiconductor body (11) which comprises at least one semiconductor element, wherein, after formation of the element, a layer structure is formed which comprises at least one electrically insulating layer (2) or an electrically conductive layer (3), wherein an opening is formed in the layer structure with the aid of a patterned photoresist layer (4) and an etching process, wherein residues are formed on the surface of the semiconductor body (11) during the etching process, and wherein the photoresist layer (4) is ashed, after the etching process, by means of a treatment with an oxygen-containing compound, after which the surface is subjected to a cleaning operation using a cleaning agent comprising a diluted solution of an acid in water and being heated to a temperature above room temperature, thereby causing the residues formed to be removed.Type: GrantFiled: July 8, 2004Date of Patent: December 1, 2009Assignee: NXP B.V.Inventors: Ingrid Annemarie Rink, Reinoldus Bernardus Maria Vroom
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Patent number: 7625827Abstract: A corrosion-resistant lath is provided for use in exterior finishing systems, such as stucco systems and exterior insulation and finish systems (“EIFS”). The lath includes in a first embodiment an open, woven fabric comprising weft and warp yarns containing non-metallic fibers, such as glass fibers. A portion of the weft yarns are undulated, resulting in an increased thickness for the fabric. The fabric is coated with a polymeric resin for substantially binding the weft yarns in the undulated condition. This invention also includes methods for making an exterior finish system and building wall including an exterior finish system using such a lath.Type: GrantFiled: December 19, 2003Date of Patent: December 1, 2009Assignee: BASF Construction Chemicals, LLCInventors: William F Egan, Mark J Newton, Mark W Tucker
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Patent number: 7625828Abstract: An insulation product is provided comprising a low density mat containing randomly oriented inorganic fibers bonded by a heat cured binder. The mat has first and second major surfaces and a pair of side portions. A nonwoven sheet is bonded to the first major surface. The nonwoven sheet comprises randomly oriented glass fibers and is bonded to the first major surface by the heat cured binder.Type: GrantFiled: January 8, 2004Date of Patent: December 1, 2009Assignee: Certainteed CorporationInventors: David I. Suda, Michael J. Lembo, Andreas H. Unruh, Joyce A. Chunko, Richard J. Ray, Jr.
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Patent number: 7625829Abstract: An elastomeric film is bonded between two or more layers of nonwoven webs formed of nonelastomeric thermoplastic fibers. The laminate has, in a predefined transverse direction, an elastic elongation value greater than the predefined elastic elongation value of the nonwoven webs, and an ultimate force to break in the predefined transverse direction of at least 3000 g/in. The laminate advantageously provides a tear resistant, multiple ply, fabric that is soft to the touch as a result of the outwardly disposed nonwoven webs, and has a high elastic modulus. The laminate is particularly useful in applications where closure portions of a product must be stretched to keep the product in place when worn.Type: GrantFiled: January 27, 2000Date of Patent: December 1, 2009Assignee: Tredegar Film Products CorporationInventors: James W. Cree, Jeffrey A. Middlesworth, Stephen D. Bruce
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Patent number: 7625830Abstract: The present invention provides a blue glass that can be essentially free of selenium and cobalt but still has a blue color and desired luminous transmittance. Additionally, the amount of iron present is comparable to conventional soda-lime-silica glass. The glass of the present invention can have a soda-lime-silica glass base portion, with major colorants that provide the blue color.Type: GrantFiled: February 10, 2005Date of Patent: December 1, 2009Assignee: PPG Industries Ohio, Inc.Inventors: Larry J. Shelestak, James M. Baldauff
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Patent number: 7625831Abstract: Anisotropically shaped ceramic particles are represented by the general formula {(K1?x?yNaxLiy)4(Nb1?zTaz)6O17+aMeOb} (where Me is at least one element selected from the group consisting of antimony, copper, manganese, vanadium, silicon, titanium, and tungsten; and b is a positive number determined by the valence of Me), where x, y, z, and a satisfy 0?x?0.5, 0?y?0.3, 0?z?0.3, and 0.001?a?0.1, respectively. The anisotropically shaped ceramic particles have a plate-like shape. The average particle size is 1 to 100 ?m, and the ratio D/t of the maximum diameter D of a main surface to the thickness t in a direction perpendicular to the main surface is 2 or more, preferably 5 or more. Thus, anisotropically shaped ceramic particles suitable as a reactive template for preparing a crystal-oriented alkali metal niobate-based ceramic can be produced at relatively low production costs without the need for a complicated production process.Type: GrantFiled: July 10, 2008Date of Patent: December 1, 2009Assignee: Murata Manufacturing Co., Ltd.Inventors: Masahiko Kimura, Kosuke Shiratsuyu
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Patent number: 7625832Abstract: A catalyst for the hydroprocessing of organic compounds, composed of an interstitial metal hydride having a reaction surface at which monatomic hydrogen is available. The activity of the catalyst is maximized by avoiding surface oxide formation. Transition metals and lanthanide metals compose the compound from which the interstitial metal hydride is formed. The catalyst's capabilities can be further enhanced using radio frequency (RF) or microwave energy.Type: GrantFiled: December 5, 2006Date of Patent: December 1, 2009Assignee: Carnegie Mellon UniversityInventors: David A. Purta, Marc A. Portnoff, Faiz Pourarian, Margaret A. Nasta, Jingfeng Zhang
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Patent number: 7625833Abstract: A method of making a five-layer membrane electrode assembly is provided which includes the steps of: providing a catalyst coated membrane web; providing a laminating station wherein the catalyst coated membrane web is drawn between a pair of laminating rollers which form a laminating nip; die-cutting first and second webs of gas diffusion layer material to make first and second gas diffusion layers; feeding first and second gas diffusion layers into the laminating nip adjacent to the catalyst coated membrane web; and laminating the first gas diffusion layer, catalyst coated membrane web and second gas diffusion layer to form a laminate.Type: GrantFiled: December 29, 2006Date of Patent: December 1, 2009Assignee: 3M Innovative Properties CompanyInventor: David R. Mekala
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Patent number: 7625834Abstract: In a method of producing a catalyst for the production of methacrylic acid, which has a composition of the following formula (1), when mixing 100 parts by mass of a solution or a slurry (liquid A) containing molybdenum atoms, phosphorous atoms and vanadium atoms in which the content of ammonium species is 0 to 1.5 mol relative to 12 mol of the molybdenum atoms, 5 to 300 parts by mass of a solution or a slurry (liquid B) containing 6 to 17 mol of ammonium species relative to 12 mol of the molybdenum atoms contained in the liquid A and a solution or a slurry (liquid C) containing an element Z such as cesium, the liquid B is mixed with the liquid A, the liquid C or a mixture of the liquid A and the liquid C over 0.1 to 15 minutes PaMobVcCudXeYfZgOh??(1).Type: GrantFiled: July 4, 2003Date of Patent: December 1, 2009Assignee: Mitsubishi Rayon Co., Ltd.Inventors: Hiroyuki Naitou, Takashi Karasuda
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Patent number: 7625835Abstract: A composite photocatalyst includes a semiconducting core and a nanoscale particle disposed on a surface of the semiconducting core, wherein the nanoscale particle is an electron carrier, and wherein the photocatalyst is sensitive to visible light irradiation.Type: GrantFiled: June 7, 2006Date of Patent: December 1, 2009Assignees: GM Global Technology Operations, Inc., Pohang University of Science and TechnologyInventors: Wei Li, Se H. Oh, Jae S. Lee, Jum S. Jang
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Patent number: 7625836Abstract: To provide a heat-resistant oxide which is excellent in heat resistance and durability at high temperature and has high activity, a heat-resistant oxide which has an oxide crystal structure and in which a rate of a solid solution of a noble metal in the oxide crystal structure is 50% or more is obtained by heat-treating (secondarily baking) a precursor composition comprising zirconia, at least one coordinative element selected from the group consisting of rare earth elements, alkaline earth elements, aluminum and silicon, and at least one noble metal selected from the group consisting of platinum, rhodium and palladium at 650° C. or higher.Type: GrantFiled: December 13, 2005Date of Patent: December 1, 2009Assignees: Cataler Corporation, Daihatsu Motor Co., Ltd.Inventors: Satoshi Matsueda, Mareo Kimura, Naoto Miyoshi, Yoshinori Ishii, Hirohisa Tanaka, Isao Tan, Mari Uenishi, Masashi Taniguchi
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Patent number: 7625837Abstract: A composition, containing vanadium, potassium and a support is disclosed. A method of preparing such composition is also disclosed. The composition is employed in a process to remove a heavy metal from a gaseous feed stream which can optionally include a separate heavy metal adsorption stage.Type: GrantFiled: June 21, 2005Date of Patent: December 1, 2009Assignee: ConocoPhillips CompanyInventors: Glenn W. Dodwell, Joseph B. Cross, Marvin M. Johnson, Edward L. Sughrue, II, Jianhua Yao
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Patent number: 7625838Abstract: The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formula and its corresponding enol-form, wherein X represents O, S, or NH; R1 represents H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, Ar, —C(O)NHR3, —C(O)—R3 or halo; R2 represents H, C1-3 alkyl or halo; R3 represents H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl or Ar; n represents 0, 1, 2 or 3; Y represents a carrier. The present invention also relates to a method of producing said adsorbent as well as use thereof for separating substances by affinity chromatography.Type: GrantFiled: June 17, 2009Date of Patent: December 1, 2009Assignee: GE Healthcare Bio-Sciences ABInventors: Mathias Alterman, Andreas Axen, Enrique Carredano, Anna Gronberg, Jinyu Zou
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Patent number: 7625839Abstract: Activated carbon adapted for electric double layer capacitors is provided, which capacitors can give a large power density per unit volume and which capacitors, even when charge-and-discharge cycle is repeated under a large current or a constant voltage is continuously applied for a long time, undergo less decrease in output density. In particular, the present invention relates to the activated carbon manufactured by carbonization of coconut shell, which has a BET specific surface area of 2000 m2/g to 2500 m2/g, an average pore diameter of 1.95 nm (19.5 ?) to 2.20 nm (22 ?) and a pore volume of pores having a pore diameter calculated according to a Cranston-Inkley method of 5.0 nm (50 ?) to 30.0 nm (300 ?), of 0.05 cm3/g to 0.15 cm3/g.Type: GrantFiled: June 21, 2006Date of Patent: December 1, 2009Assignees: Mitsubishi Chemical Corporation, Toyota Jidosha Kabushiki KaishaInventors: Satoshi Hirahara, Yositaka Takeda, Kazuyuki Toki
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Patent number: 7625840Abstract: A nanoporous catalytic membrane which displays several unique features including pores which can go through the entire thickness of the membrane. The membrane has a higher catalytic and product selectivity than conventional catalysts. Anodic aluminum oxide (AAO) membranes serve as the catalyst substrate. This substrate is then subjected to Atomic Layer Deposition (ALD), which allows the controlled narrowing of the pores from 40 nm to 10 nm in the substrate by deposition of a preparatory material. Subsequent deposition of a catalytic layer on the inner surfaces of the pores reduces pore sizes to less than 10 nm and allows for a higher degree of reaction selectivity. The small pore sizes allow control over which molecules enter the pores, and the flow-through feature can allow for partial oxidation of reactant species as opposed to complete oxidation. A nanoporous separation membrane, produced by ALD is also provided for use in gaseous and liquid separations.Type: GrantFiled: September 14, 2004Date of Patent: December 1, 2009Assignee: UChicago Argonne, LLC.Inventors: Michael J. Pellin, John N. Hryn, Jeffrey W. Elam
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Patent number: 7625841Abstract: The invention relates to novel substituted thiene-3-ylsulphonylamino(thio)carbonyl-triazolin(ethi)ones of the formula (I) in which Q1, Q2, R1, R2, R3 and R4 are as defined in the disclosure, except for prior-art compounds. The invention further relates to the preparation of the compounds, to their use as herbicides, and to herbicidal compositions comprising the novel compounds.Type: GrantFiled: June 13, 2008Date of Patent: December 1, 2009Assignee: Bayer CropScience AGInventors: Ernst Rudolf F. Gesing, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
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Patent number: 7625842Abstract: The invention relates to 5-(oximinoalkyl- and hydrazonalkyl-amino)pyrazole derivatives of formula (I) or salts thereof: formula (I), wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths).Type: GrantFiled: December 22, 2006Date of Patent: December 1, 2009Assignee: Merial LimitedInventors: David Chou, Werner Knauf, Michael Maier, Friederike Lochhaas, Karl Seeger
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Patent number: 7625843Abstract: There is provided a method of fabricating a precursor solution for a metal organic deposition method using a superconducting oxide as a starting material, wherein the method includes dispersing a superconducting material powder in a TFA acid aqueous solution, heating to dissolve the powder in the TFA solution, increasing a temperature of a hot substrate if the powder is completely dissolved and the solution is clear, continuously heating until the solution is vaporized and is in a viscous jelly state, stopping heating if the solution loses its flowing property completely, cooling the solution, and dissolving the compound in the jelly state, hardened at a room temperature, into an organic solvent to provide a metal organic deposition solution for coating. There is also provided a method of fabricating a thin film-type superconductor using a metal organic deposition method.Type: GrantFiled: January 13, 2006Date of Patent: December 1, 2009Assignee: Korea Institute of Machinery & MaterialsInventors: Gye-Won Hong, Hee-Gyon Lee, Sang-Im Yoo, Jai-Moo Yoo
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Patent number: 7625844Abstract: The instant invention provides a live labeling microorganism assay for screening a one-bead one-compound library to identify synthetic anti-adherent compounds for blocking biofilm formation. The compounds of libraries may be peptides, small molecules, nucleic acids, other types of molecules or a combination of the foregoing. The live labeling microorganisms are incubated with a one-bead one-compound library for a long period with fresh-labeled bacteria and nutrition replacement in regular intervals. Those beads without bacterial adhesion are transferred into nutritional agar for the culture. The true anti-adherent beads are isolated and the sequences of each isolated compound-bead are determined with sequencer. The anti-adherent compounds identified in this invention are proved to possess long-term effect of blocking bacterial adhesion and biofilm formation.Type: GrantFiled: April 17, 2006Date of Patent: December 1, 2009Assignee: Biopath Laboratory Incorporated (Delaware)Inventors: Fan Yang, Guang Yang
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Patent number: 7625845Abstract: A thermal insulating fluid contains microspheres of hollow spherical particulates. The presence of the hollow spherical particles improves the thermal insulating properties of the fluid by imparting to the thermal insulating fluid a low heat transfer coefficient. The hollow particulates may be inorganic or organic in nature and include hollow spheres of glass, ceramics and plastics. The thermal insulating fluid is capable of controlling the heat transfer from a production tubing or transfer pipe to one or more surrounding annuli and the environment. In addition to reducing heat transfer in the producing well, heat transfer in the fluid produced from the well is also minimized.Type: GrantFiled: November 9, 2006Date of Patent: December 1, 2009Assignee: BJ Services CompanyInventors: Xiaolan Wang, Qi Qu
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Patent number: 7625846Abstract: Degradable polylactic or polyhydroxyalkanoate polymers may be used to viscosify aqueous fluids for use in wells. Sand control screen or liner can be coated with a solid degradable polymer during placement in a well. Mechanical changes or flow changes in a well can be caused by solid degradable polymer that changes physical properties after it is placed in a well. Parts of devices or entire devices can be made of solid degradable polymer that converts to a fluid after selected times in an aqueous environment in a well.Type: GrantFiled: May 18, 2007Date of Patent: December 1, 2009Inventor: Claude E. Cooke, Jr.
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Patent number: 7625847Abstract: Disclosed are lubricating oil compositions comprising a lubricating base oil, (A) a specific alkali metal or alkaline earth metal salicylate and/or an overbased or basic salt thereof in an amount of 0.005 to 5 percent by mass in terms of metal and (B) a phosphorus-containing anti-wear agent in an amount of 0.005 to 0.2 percent by mass in terms of phosphorus and containing sulfur in an amount of 0.3 percent by mass or less, based on the total mass of the composition, the salicylate being any of salicylates fulfilling specific requirements. The lubricating oil compositions are low sulfur lubricating oils which are extremely excellent in anti-wear properties and long drain properties and suitable for an internal combustion engine.Type: GrantFiled: February 1, 2005Date of Patent: December 1, 2009Assignee: Nippon Oil CorporationInventor: Kazuhiro Yagishita
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Patent number: 7625848Abstract: An anti-traction material is disclosed which may be used as a coating on a variety of surfaces over which people and vehicles may find it difficult to traverse. The anti-traction material may include polymer particles capable of absorbing or being dissolved by a fluid and a fluid capable of absorbing or dissolving the polymer particles. The anti-traction material may include hydrophobic particles which may then control the rate and/or amount of fluid absorption of the polymer particles which may therefore improve storage capability and polymer particle flow behavior.Type: GrantFiled: September 5, 2006Date of Patent: December 1, 2009Assignee: Southwest Research InstituteInventors: Ronald J. Mathis, Mary C. Marshall, Nicholle K. Reinhardt, Errol M. Brigance, Geronimo I. Elias, Dennis S. Rushforth
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Patent number: 7625849Abstract: Mixtures comprising amorphous phenolic stabilisers and at least one reducing agent.Type: GrantFiled: October 28, 2003Date of Patent: December 1, 2009Assignee: BASF AktiengesellschaftInventors: Hauke Malz, Thomas Flug, Sylvia Rybicki
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Patent number: 7625850Abstract: A high-temperature lubricating oil composition is provided, which is resistant to hardening and sludge formation, and displays minimal evaporation loss and superior thermal stability, even under practical high-temperature open system conditions such as those found in a tenter. A lubricating oil composition that provides excellent lubrication without damaging members used within working machinery is also provided. The lubricating oil composition comprises a polyolester based synthetic oil and a C12 to C72 fatty acid and/or a diphenylamine derivative containing an arylalkyl group with a number average molecular weight of 400 to 800.Type: GrantFiled: March 24, 2005Date of Patent: December 1, 2009Assignees: Mitsubishi Heavy Industries, Ltd., Sato Special Oil Co., Ltd.Inventors: Norihisa Horaguchi, Shiki Matsuo, Hideo Kometani, Naomoto Ishikawa, Tatsushi Seko, Yusuke Kinoshita, Masaru Seto, Kimihito Hitotsumatsu
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Patent number: 7625851Abstract: A polymeric viscosity index improver that includes a hydrogenated block copolymer having at least one controlled distribution block copolymer having a minimized crystallinity is provided. An oil composition including at least a base oil and the aforementioned viscosity index improver is also provided. A polymeric concentrate including the aforementioned viscosity index improver is further provided.Type: GrantFiled: March 7, 2007Date of Patent: December 1, 2009Assignee: Kraton Polymers US LLCInventor: David John St. Clair
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Patent number: 7625852Abstract: The present invention provides a nail polish remover comprising isobutyl nitrite and butylated linseed oil as active ingredients for nail polish removal, conditioning and adhesion promotion.Type: GrantFiled: June 6, 2007Date of Patent: December 1, 2009Inventors: Henry Hadry, Everett Farr
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Patent number: 7625853Abstract: The present invention relates to the use of polypropylene glycol(3) myristyl ether as preferably the sole viscosity regulator, care active ingredient and solubilizer in aqueous surface-active formulations, preferably having a water content of at least 75% by weight. The present invention further provides aqueous surface-active formulations comprising at least 0.5% by weight, preferably at least 2% by weight, of polypropylene glycol(3) myristyl ether, at least 5% by weight, preferably at least 10% by weight, of at least one surfactant and at least 75% by weight, preferably at least 85% by weight, of water and liquid body cleansing compositions, in particular shower baths and hair shampoos, comprising such an aqueous surface-active formulation.Type: GrantFiled: July 21, 2008Date of Patent: December 1, 2009Assignee: Evonik Goldschmidt GmbHInventors: Holger Leidreiter, Uta Kortemeier
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Patent number: 7625854Abstract: Ternary azeotrope and azeotrope-like compositions containing 1,1,1,2,3,3-hexafluoro-3-methoxy-propane, 1-bromopropane and a third component, and uses thereof, are described.Type: GrantFiled: January 17, 2008Date of Patent: December 1, 2009Assignee: 3M Innovative Properties CompanyInventor: John G. Owens
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Patent number: 7625855Abstract: A cleaning composition for removing organic deposits from hard to reach surfaces. In its basic embodiment, the cleaning composition comprises: a) a water miscible solvent; b) an inorganic salt in crystal form; and c) water. The inorganic salt in crystal form comprises from about 30 to about 70% weight of the total composition.Type: GrantFiled: July 26, 2004Date of Patent: December 1, 2009Inventor: Gustavo M. Gonzalez
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Patent number: 7625856Abstract: The invention relates to a water-soluble container which contains a composition useful for hard surface cleaning. The composition comprises at least one surfactant selected from non-ionic surfactant, anionic surfactant, and mixtures thereof, at least 70% wt. of at least one organic solvent having a solubility in water of at least 4% wt., optionally at least one alkanolamine; and optionally, conventional additives. The water soluble containers can be made by thermoforming or injection molding.Type: GrantFiled: August 15, 2003Date of Patent: December 1, 2009Assignee: Reckitt Benckiser Inc.Inventors: Diane Joyce Burt, Ralph Gencarelli, Sophie Strzepek
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Patent number: 7625857Abstract: Compositions comprising cationic high amylose starch are effective for use in fabric care compositions.Type: GrantFiled: February 28, 2007Date of Patent: December 1, 2009Assignee: The Procter & Gamble CompanyInventors: Alice Marie Ward, Yonas Gizaw
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Patent number: 7625858Abstract: The concentrated liquid fabric softening composition of the present invention comprises an ester-linked triethanolamine (TEA) quaternary ammonium fabric softening material having an Iodine Value of between 0 and 60 and comprising a mixture of at mono-, di- and tri-ester linked components; a single long chain cationic surfactant which has one or more ethoxylate groups and preferably has a methylsulphate counter-ion, and a co-fragmenting agent which is a polyol selected from trihydric and polyhydric polyols. The compositions have a desirable pearly appearance which is stable across a range of storage temperatures.Type: GrantFiled: August 21, 2008Date of Patent: December 1, 2009Assignee: The Sun Products CorporationInventor: Mansur Sultan Mohammadi
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Patent number: 7625859Abstract: There is disclosed a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an iso lated polypeptide having from about 50 to 79 amino acids taken from the sequence of SEQ ID NO. 1, wherein the polypeptide binds to the extracellular domain ECD of HER-2 with an affinity binding constant of at least 108 M?1, (b) an isolated and glycosylated polypeptide having from about 300 to 419 amino acids taken from the sequence of SEQ ID NO. 2, wherein the C terminal 79 amino acids are present, and wherein at least three N-linked glycosylation sites are present, (c) a monoclonal antibody that binds to the ECD of HER-2, and (d) combinations thereof, with the proviso that the agent cannot be the monoclonal antibody alone, and pharmaceutically acceptable carrier. Also disclosed are prognostic and diagnostic assays.Type: GrantFiled: February 16, 2000Date of Patent: December 1, 2009Assignee: Oregon Health & Science UniversityInventors: Gail M. Clinton, Adam Evans, William D. Henner
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Patent number: 7625860Abstract: Methods and compositions for modulating the FGF effect on the sensitivity of malignant and normal cells to anticancer agents are provided. In particular, methods and compositions for inhibiting FGF-induced resistance to a broad spectrum of anticancer agents in solid and soft-tissue tumors, metastatic lesions, leukemia and lymphoma are provided. Preferably, the compositions include at least one FGF inhibitor in combination with a cytotoxic agents, e.g., antimicrotubule agents, topoisomerase I inhibitors, topoisomerase II inhibitors, antimetabolites, mitotic inhibitors, alkylating agents, intercalating agents, agents capable of interfering with a signal transduction pathway (e.g., g., a protein kinase C inhibitor, e.g., an anti-hormone, e.g., an antibody against growth factor receptors), an agent that promotes apoptosis and/or necrosis, an interferon, an interleukin, a tumor necrosis factor, and radiation.Type: GrantFiled: June 18, 2003Date of Patent: December 1, 2009Inventors: Jessie L.-S. Au, M. Guillaume Wientjes
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Patent number: 7625861Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.Type: GrantFiled: January 23, 2007Date of Patent: December 1, 2009Assignee: Yeda Research and Development Co., Ltd.Inventors: Eliezer Konfino, Michael Sela, Dvora Teitelbaum, Ruth Arnon
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Patent number: 7625862Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.Type: GrantFiled: March 13, 2007Date of Patent: December 1, 2009Assignee: Sangart, Inc.Inventors: Robert M. Winslow, Kim D. Vandegriff
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Patent number: 7625863Abstract: Isolated peptides and polynucleotides are provided that can be used to treat a subject that has a genetic predisposition to, or has been diagnosed as having, a cardiac disorder related to dysfunctional sodium channels. Also provided are methods of treatment, as well as methods of predicting the occurrence of a cardiac event or the severity or prognosis of cardiac symptoms, in a subject that has either been diagnosed as having, or is suspected of developing, a sodium channel related cardiac disorder, by testing the subject for the presence of H558R-polymorphism on the subject's SCN5A gene.Type: GrantFiled: October 29, 2007Date of Patent: December 1, 2009Assignee: The MetroHealth SystemInventor: Isabelle Deschenes
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Patent number: 7625864Abstract: The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.Type: GrantFiled: June 30, 2008Date of Patent: December 1, 2009Assignee: Children's Medical Center CorporationInventors: Larry I. Benowitz, Yuqin Yin
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Patent number: 7625865Abstract: The invention describes novel dried powders of peptide therapeutic agent useful for producing highly respirable aerosols and the methods for their manufacture. Insulin is the peptide therapeutic agent in the preferred embodiment. The powders of insulin prepared for pulmonary administration are characterized by the peculiar structure and shape of the microparticles that allow the powder to flow and to be easy aerosolized. Typical dry powder of insulin described in this patent show corrugated, nonagglomerated microparticles with a low tapped density. The mean geometric diameter (particle size) ranges between 1.0 and 10.0 micron and the mass median aerodynamic diameter (MMAD) ranges between 1.0 and 4.0 micron. These insulin pulmonary powders exhibit in vitro a very high respirable fraction (>75%).Type: GrantFiled: March 26, 2004Date of Patent: December 1, 2009Assignee: Universita Degli Studi Di ParmaInventors: Paolo Colombo, Stefano Cagnani, Paolo Ventura
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Patent number: 7625866Abstract: The invention relates to a concentrate and a process for producing a factor VIII:C-containing von Willebrand factor by fractional precipitation from a liquid comprising factor VIII:C and von Willebrand factor, resulting in an increased content of high molecular weight multimers of von Willebrand factor and a ratio of the vWF:RCoF activity to vWF:Ag of greater than 1.Type: GrantFiled: September 26, 2003Date of Patent: December 1, 2009Assignee: CSL Behring GmbHInventors: Gerhardt Kumpe, Manfred Juraschek, Natascha Mayer, Stefan Schulte, Wilfried Wormsbächer
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Patent number: 7625867Abstract: The present invention provides compositions and methods for promoting bone growth. The present invention also provides methods of screening compounds that modulate BMP-3A or BMP-3B activity. The compositions and methods provided herein are useful in modulating bone growth.Type: GrantFiled: March 28, 2005Date of Patent: December 1, 2009Assignee: Acceleron Pharma Inc.Inventors: John Knopf, Jabir Seehra
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Patent number: 7625868Abstract: Methods for inhibiting angiogenesis in endothelial cells and selectively inducing apoptosis in endothelial cells via compounds which binds annexin II are provided. These compounds and methods for using these compounds are useful in the treatment of diseases or disorders characterized by unwanted angiogenesis. Also provided are pharmaceutical compositions containing a compound which binds annexin II and a pharmaceutically acceptable vehicle and methods for identifying such compounds.Type: GrantFiled: January 5, 2007Date of Patent: December 1, 2009Assignee: Philadelphia, Health and Education CorporationInventors: Mahesh C. Sharma, George P. Tuszynski
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Patent number: 7625869Abstract: The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.Type: GrantFiled: June 23, 2005Date of Patent: December 1, 2009Assignee: Takeda Pharmaceutical Company LimitedInventors: Chieko Kitada, Taiji Asami, Naoki Nishizawa
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Patent number: 7625870Abstract: The invention refers to the medicinal remedies for respiratory system diseases treatment and may be applied as a substance, capable of restoring respiratory organs functions and used for treatment of different forms of lung pathology. There is proposed a biologically active new tetrapeptide alanyl-glutamyl-aspartyl-leucine of the general formula Ala-Glu-Asp-Leu, capable of restoring respiratory organs function. There is proposed a pharmaceutical substance, containing as an active peptide agent an effective amount of tetrapeptide alanyl-glutamyl-aspartyl-leucine of the general formula Ala-Glu-Asp-Leu, which if used in the medical preparation contributes to the restoration of the respiratory organs function.Type: GrantFiled: December 7, 2004Date of Patent: December 1, 2009Assignee: “Access Bioscience” CJSCInventors: Vladimir Khatskelevich Khavinson, Galina Anatolievna Ryzhak, Evgeny Iosifovich Grigoriev, Irina Yurievna Ryadnova
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Patent number: 7625871Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.Type: GrantFiled: February 28, 2008Date of Patent: December 1, 2009Assignee: The Regents of the University of MichiganInventors: Leroy B. Townsend, John C. Drach
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Patent number: 7625872Abstract: The invention provides immunomodulatory compounds and methods for immunomodulation of cells and individuals using the immunomodulatory compounds.Type: GrantFiled: December 17, 2003Date of Patent: December 1, 2009Assignee: Dynavax Technologies CorporationInventor: Karen L. Fearon