Abstract: The present invention proposes a method for calculating, presenting, and combining probabilistic functional maps (PFMs) of the human brain representing the probability of structures existing. The method comprises three major steps: reading of data containing the coordinates of contacts, calculating the PFMs, and presenting the PFMs. The data can be read from a file in text or binary format or from a database as local or remote client. The PFM calculation comprises the following steps: forming 3D models of contacts, normalizing the contact models, voxelizing the contact models, calculating an atlas function, and calculating the PFM. The PFM can be presented alone or along with anatomical atlases. Both 3D and 2D interfaces can be used for presentation. The proposed method also includes different ways of combining the contact data and/or existing PFMs from multiple sources. This mechanism is the basis of an internet portal for stereotactic and functional neurosurgery.

Abstract: Devices, systems and methods are disclosed for a neural access device that includes an implant which transcutaneously exits the skin of a patient and provides transport of signals between a sensor implanted in a patient and an external device. The transcutaneous implant has integrated features to provide reduced risk of injury due to mechanical forces as well as electrostatic discharge energy applied to the external portion of the device. Transcutaneous devices which provide wireless communication between a sensor and an external device are also disclosed.

Abstract: A system and method for prediction of cognitive decline, comprises an input receiving input data corresponding to brain activity of an individual and a processor coupled to the input for analyzing the input data to obtain a selected set of features, the processor comparing the selected set of features to at least a portion of entries in a database corresponding to brain activity of a plurality of individuals, wherein entries in the database have been separated into a plurality of categories corresponding to one of a degree of cognitive decline and a propensity for future cognitive decline of individuals relating to the entries, the processor determining, based on the comparison, a category most closely corresponding to the selected set of features.

Abstract: Provided herein is a device for controlling the release of a substance at a site of interest in a biological membrane comprising a means of monitoring a physiological state at the site of interest; and a means of releasing a variable amount of the substance to the site of interest where the amount varies in response to the status of the monitored physiological state. Also provided are methods of using the device.

Abstract: Methods, apparatus, and kits for onychomycosis treatment are presented. In one embodiment, a kit for treatment includes an anti-fungal agent, in a composition, and an electrically powered patch. Exemplary embodiments of the patch include a first electrode, a power source having a first and second terminal, a second electrode coupled to the second terminal of the power source, and a base member supporting the first electrode, the second electrode, and the power source. Embodiments include those where the first and second electrode and power source are printed on the base member. Anti-fungal agents may be unionized while the composition includes an ionizing agent. Home use may be practiced, as embodiments include those in which the voltage or current of the power source cannot be adjusted by a user. Exemplary methods include the selection of a nail or diseased area to which treatment is desired and administering the kit as described.

Abstract: Various system embodiments comprise a neural stimulator and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to elicit sympathetic activity at a neural target. The controller is adapted to control the neural stimulator to provide a physical conditioning therapy. The controller is adapted to control the neural stimulator to intermittently elicit sympathetic activity at the neural target. Other aspects and embodiments are provided herein.

Abstract: A cardiac contractility modulating (CCM) device (30) includes an anti-arrhythmic therapy unit (38) for detecting a cardiac arrhythmia in a heart (2) of a patient based on processing electrical signals related to cardiac activity sensed at the heart, and for delivering anti-arrhythmic therapy to the heart. The device includes a cardiac contractility modulating (CCM) unit (40) capable of delivering cardiac contractility modulating (CCM) signals to the heart for modulating the contractility of a portion of the heart. The device may provide to the anti-arrhythmic therapy unit control signals associated with the delivery of the CCM signals to the heart. The control signals may be used to prevent interference of the CCM signals with the detecting of the cardiac arrhythmia. The device (30) includes a power source. The device may be an implantable device or a non-implantable device. The device may also include a pacing unit.

Abstract: In general, the invention is directed to techniques for detecting and addressing pacemaker syndrome. When a pacemaker detects a risk of pacemaker syndrome, the pacemaker paces one or more chambers of the heart to reduce the risk of pacemaker syndrome. One pacing technique is to apply ventricular paces, thereby reducing the delay between the atrial activation and the ventricular activation. Another technique, available to a patient who receives atrial pacing, is to decrease the atrial pacing rate.

Abstract: A method and apparatus for analyzing IEGM waveforms is disclosed. The method includes generating a long term ensemble average of a plurality of baseline IEGM waveforms and generating a short term ensemble average of at least a portion of the plurality of baseline IEGM waveforms. The method further includes determining a short term absolute point value as a function of the absolute value of the difference of the amplitude of the short term ensemble average and a test IEGM waveform and a long term absolute point value as a function of the difference of the amplitude of the long term ensemble average and the test waveform at a plurality of sample points. The disclosed method further includes detecting ischemia if the difference between the short term absolute point value and the long term absolute point value is greater than an ischemia detection threshold.

Abstract: A method and an apparatus for treating cardiac arrhythmias are provided. An interval between first and second consecutive beats of a heart, having first and second chamber types, is determined. The heart is paced at a first rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is less than a predetermined amount of time or if the first and second beats are both from the second chamber type. The heart is paced at a second rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is more than the predetermined amount of time.

Abstract: It has been discovered that a change in posture that results in an increase in orthostatic stress, when followed by a withdrawal of sympathetic nervous activity, may indicate a future onset of vasovagal syncope (VVS). The invention is directed to devices and techniques for early detection of an episode of VVS so that therapies may be applied in advance of the episode to prevent the episode from occurring. Detection of a posture transition triggers a device such as an implanted pacemaker to determine an indicator of an autonomic nervous system activity of the patient. As a function of this determination, the device estimates a probability that the patient will experience VVS. When the probability exceeds a threshold, preventative therapy may be applied to address the VVS and to reduce the risk that the patient will faint.

Abstract: Techniques for applying overdrive pacing to one or both atria following termination of an AF episode, to prevent a recurrent AF episode. An implantable medical device such as a pacemaker applies overdrive pacing according to overdrive pacing parameters, and sets the parameters as a function of the response of the patient to overdrive pacing. The parameters may be adjusted upward or downward, so that overdrive pacing may be applied effectively but not over-applied.

Abstract: Methods and systems involve selecting lead configurations in a pulse generator capture verification system. Capture threshold data is collected from at least one alternative electrode configuration. The capture threshold data from the at least one alternative electrode configuration is compared with capture threshold data collected using a primary electrode configuration. A pacing electrode configuration is selected based on the comparison. Backup safety pacing is provided using the primary electrode configuration.

Abstract: Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrode assemblies that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Also disclosed are various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.

Abstract: In an implantable medical device and a manufacturing method therefore, the implantable medical device has at least an electronics module and a battery module, each contributing functionally as well as to the shape of the outer enclosure of the implantable medical device. Different modules, and different versions of different modules, can be combined in different combinations, according to a device specification, to form different medical devices.

Abstract: A connector assembly for detachably coupling a proximal end of a lead and an implantable medical device. The connector assembly includes a deflectable connector clip having a first arm, a second arm and a top portion extending between the first arm and the second arm. The first arm and the second arm detachably position the proximal end of the lead within the implantable medical device. A housing portion has a first deflection portion that deflects the connector clip from a first position corresponding to a first distance between the first arm and the second arm, to a second position corresponding to a second distance between the first arm and the second arm. Subsequent advancement of the lead through the first and second arms further deflects the connector clip from the second position to a third position, which transfers all of the spring force of the connector clip to the lead.

Abstract: Devices and methods are provided for electrically stimulating a predetermined body part of a mammal. The method includes placing at least one electrode in proximity to the mammal's skin, injecting an electrically conductive gel into the body of the mammal so as to form a conductive gel pathway extending at least partially along a distance between the at least one electrode and the predetermined body part, and stimulating the predetermined body part by applying an electrical signal via the electrode that travels, at least in part, through the conductive gel pathway.

Abstract: In a method of implanting an electrode of an electronic stimulator device into an external urinary sphincter of a male patient, a first incision is made in the perineum of the patient between the anus and the scrotal-perineal junction. A distal end of a stimulation lead is then fed through the first incision, through the perineal membrane and into the external urinary sphincter. The distal end includes the electrode. In one embodiment of the method, a second incision is made in the abdomen of the patient. In one embodiment, the second incision is made lateral to and cephalad to the pubis bone of the patient. Next, a proximal end of the stimulation lead is fed from the first incision to the second incision. In one embodiment, the proximal end of the stimulation lead is coupled to a control unit of the electronic stimulator device. Electrical signals are generated using the control unit and the electrical signals are delivered to the external urinary sphincter through the stimulation lead and the electrode.

Abstract: An aspect relates to a system for providing baroreflex stimulation. An embodiment of the system comprises a heart rate monitor to sense a heart rate and provide a signal indicative of the heart rate, and a baroreflex stimulator. The stimulator includes a pulse generator to intermittently generate a stimulation signal to provide baroreflex stimulation for a baroreflex therapy, and further includes a modulator to adjust the stimulation signal based on the signal indicative of the heart rate such that the stimulation signal provides a desired baroreflex stimulation corresponding to a desired heart rate.

Abstract: A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug infusion or electrostimulation. Apparatus can be permanently implanted or catheter based.

Abstract: Techniques for collection and management of data relating to neurostimulation therapy involve selection of questions for the user to answer based on the context of the therapy delivered by the neurostimulation device at the time the questions are presented. In this manner, appropriate data may be collected for specific contexts. The techniques may involve storage of answers to the questions with information indicative of the contexts. Information indicative of the contexts may include information relating to the types of neurostimulation therapy requests made by the patient, stimulation settings associated with the neurostimulation therapy, and data and time information. The techniques may be implemented by neurostimulation therapy interface device such as a patient programmer that controls operation of an implanted neurostimulation device.

Abstract: Techniques for collection and management of data relating to neurostimulation therapy involve selection of questions for the user to answer based on the context of the therapy delivered by the neurostimulation device at the time the questions are presented. In this manner, appropriate data may be collected for specific contexts. The techniques may involve storage of answers to the questions with information indicative of the contexts. Information indicative of the contexts may include information relating to the types of neurostimulation therapy requests made by the patient, stimulation settings associated with the neurostimulation therapy, and data and time information. The techniques may be implemented by neurostimulation therapy interface device such as a patient programmer that controls operation of an implanted neurostimulation device.

Abstract: An implantable neural stimulation system, such as a cochlear implant system, utilizes a Distributed Compression Amplitude Mapping (DCAM) system to distribute signal compression between a pre-bandpass linear mapping function, and a post-bandpass compressive mapping function. The pre-bandpass linear mapping function is implemented, in one exemplary embodiment, as a traditional audio compressor to prevent distortion that might result from a non-linear mapping function. The post-bandpass compressive mapping function is implemented, in another exemplary embodiment, as a logarithmic transform to reflect natural hearing. As a result of the DCAM processing, the differences in amplitudes of components of the acoustic spectrum are maintained. By maintaining these differences, spectral smearing between channels is reduced and speech clues are preserved.

Abstract: An implantable neural stimulation system, such as a cochlear implant system, utilizes a Distributed Compression Amplitude Mapping (DCAM) system to distribute signal compression between a pre-bandpass linear mapping function, and a post-bandpass compressive mapping function. The pre-bandpass linear mapping function is implemented, in one exemplary embodiment, as a traditional audio compressor to prevent distortion that might result from a non-linear mapping function. The post-bandpass compressive mapping function is implemented, in another exemplary embodiment, as a logarithmic transform to reflect natural hearing. As a result of the DCAM processing, the differences in amplitudes of components of the acoustic spectrum are maintained. By maintaining these differences, spectral smearing between channels is reduced and speech clues are preserved.

Abstract: A system for treating patients affected both by hearing loss and by balance disorders related to vestibular hypofunction and/or malfunction, which includes sensors of sound and head movement, processing circuitry, a power source, and an implantable electrical stimulator capable of stimulating areas of the cochlea and areas of the vestibular system.

Abstract: Techniques for selectably providing either constant voltage or constant current stimulation are described. A programming device provides a user interface by which a user selects either constant voltage or constant current stimulation, and selects either a voltage or current amplitude based on the selected stimulation mode. The programming device configures a medical device to provide the selected mode of stimulation at the selected amplitude. For example, when a medical device has constant voltage stimulation circuitry, e.g., circuitry including a voltage source, and the user selects constant current stimulation, the programming device configures the medical device to adjust the voltage amplitude based on a measured impedance to provide substantially constant current amplitude.

Abstract: A needle driver is described that can be used to drive a plurality of surgical needles into or proximate to tissue of a living body. The needle driver assists the surgeon in perforating the tissue, creating the tracts at a desired depth, and creating multiple tracts simultaneously. The needle driver is configured to hold the needles securely when creating the tracts, and is also configured to disengage from the needles after the tracts have been created.

Abstract: An interverterbral fissure can be treated by providing a catheter having a distal end, a proximal end, a longitudinal axis, and an intradiscal section at the catheter's distal end on which there is at least one functional element. The next step is applying a force longitudinally to the proximal of the catheter which is sufficient to advance the intradiscal section through the nucleus pulposus and around an inner wall of an annulus fibrosus, but which force is insufficient to puncture the annulus fibrosus. Next the functional element is positioned at a selected location of the disc by advancing or retracting the catheter and optionally twisting the proximal end of the catheter. Then the functional unit treats the annular fissure. Optionally, there is an additional step of adding a substance to seal the fissure.

Abstract: A catheter used to deliver a medical electrical lead to a right atrium of a heart in close proximity to a His bundle. The catheter includes a proximal portion and a distal portion.

Abstract: A time-based controller provides control for a controlled system including a plant having an integration response. The time-based controller includes a comparator that detects a polarity change in a comparison of a sensed signal from the plant and a reference signal while a control signal is in a first state, time calculation logic that, responsive to detection of the change in the comparison, determines a time at which to change a state of a control signal supplied to the plant, and a modulator that, at the determined time, changes the state of the control signal supplied to the plant from the first state to a second state.

Abstract: A process control system element for use in a process plant includes a process module, which represents a logical unit in the process plant, integrated with an expert module capable of detecting and/or mitigating abnormal situations associated with the logical unit. The process module may include a plurality of process objects, each process object representing a corresponding physical entity in the process plant. At least some of the process objects may include simulation capabilities to simulate the corresponding physical entities. The expert module may be adapted to detect at least one abnormal situation associated with the logical unit, and may be communicatively coupled to the process module to receive data from the process module during operation of the process module. Because the expert module is integrated with the process module, a user can more easily configure the expert module to detect and/or mitigate abnormal situations associated with the logical unit.

Abstract: As preset component data to perform processing on components for signal processing in a mixer engine, data for PC and data for transfer to be transferred to the mixer engine to cause the engine to perform signal processing are stored on the PC side, and data for engine is stored on the mixer engine side. When being directed to upgrade the preset component data on the mixer engine side, the PC compares the ID of each component included in the data for PC stored in the PC with the ID of each component included in the data for engine stored in the mixer engine, and, when detecting an ID existing only in the former, transfers the aforementioned data for transfer on the component corresponding to the ID to the mixer engine and causes the engine to store the data as the data for engine.

Abstract: Methods, computer-readable media, and data structures for building an authoritative database of digital audio identifier elements from digital media accessed by clients. The digital media including one or more media items, such as tracks on a CD. The methods, computer-readable media, and data structures further identifying metadata associated with a media item accessed by a client utilizing the authoritative database of digital audio identifier elements.

Abstract: An FM transmitter accessory for a digital music player having a display screen uses a microprocessor to create image files that are transferred to the digital music player such that they are displayed on its screen. When a user input on the accessory is manipulated on the accessory to select a transmission frequency for the FM transmitter, the microcontroller generates a new image file that corresponds to the selected frequency and transfers the generated image file to the digital music player such that the selected frequency is displayed on the screen of the digital music player. In addition, by constantly generating new displays based upon user inputs, the accessory can display menus on the screen of the digital music player that can be manipulated by user to select between a number of displayed options.

Abstract: Predicting a completion time for the manufacturing of an ordered configuration of a product based on actual completion times and self adjusting prediction completion times. An order is received to manufacture a particular configuration of a product. Multiple activities are identified that need to be finished in order to complete the manufacturing of the configuration. A completion time that the configuration will be manufactured is predicted based on actual completion times and self-adjusting predicted completion times for the activities.

Abstract: A system that facilitates determination of a sampling rate to utilize in connection with sampling data in an industrial environment comprises a receiver component that receives data from an I/O port of a controller. An analysis component automatically and dynamically determines a rate at which data associated with the I/O port is to be sampled based at least in part upon the received data. The system can further comprise a sampling component that samples data at the rate determined by the analysis component.

Abstract: A method of problem case packaging handling consists collecting manufacturing problem information from entities associated with fabrication of a semiconductor product; and distributing the manufacturing problem information into problem cases which are stored in a problem database, each problem case representing a respective manufacturing problem and being associated with manufacturing problem information related to that problem case.

Abstract: A computer-based method for maximizing the use of lumber in the production of truss members for a truss assembly using a linear feed saw apparatus. The method comprises storing a list of truss members to be cut by the linear feed saw apparatus, selecting from the list a first truss member for cutting, the first member having a trailing end. A second truss member from the list is selected for cutting, the second member having a first end that will nest with the trailing end of the first member. The second member is oriented such that its first end nests with the trailing end of the first member. The members are then cut using the linear feed saw. The nesting members can abut across the entire member width, only across a portion of the member width or at a single point. The nested ends of the first and second members may be bevel cuts.

Abstract: There are provided a method of operating a temperature management device. For example, there is disclosed a method of operating a temperature management device. The method comprises transmitting towards the temperature management device a probe, the probe having a pre-determined format; receiving a probe response, the probe response being representative of at least one dynamic operational characteristic of the temperature management device; analyzing the probe response to obtain a control parameter suitable for controlling operation of the temperature management device.

Abstract: A robotic data storage library comprising a virtual port and a method for providing a virtual port for a robotic data storage library are disclosed. The virtual exit port, for example, comprises one or more storage locations of the library that are defined as a virtual port. In one embodiment, for example, the virtual port comprises a virtual exit port for holding a data storage element that is to be exported from the library. In this embodiment, for example, the virtual exit port is defined prior to the library receiving a command to export a data storage element. In another embodiment, the virtual port comprises an entry port, an exit port or an entry/exit port. In yet another embodiment, a method for transferring a data storage element directly between an actual port (entry and/or exit) of a robotic data storage library and another location within the robotic data storage library not defined as the virtual port is disclosed.

Abstract: The present application is directed to an apparatus and method of managing transport of fluid commodities in a pipeline network. The method includes obtaining operational settings, which include equipment settings and measured parameters, associated with a pipeline network as a fluid commodity is transported through the pipeline network. From the operational settings, a recommendation is generated concurrently with the transport of the fluid commodity through the pipeline network to optimize at least one of the operational settings. The recommendation comprises revised equipment settings associated with equipment disposed along the pipeline network. The equipment settings in the recommendation may be based on empirical data from previous experience with the transport of fluid commodities through the pipeline network and/or based on theoretical data from modeling of the transport of the fluid commodity through the pipeline network.

Abstract: One embodiment of the application provides a method of forecasting utility demand of a utility consuming entity for a future time period. The method includes: selecting a utility demand matrix from a set of utility demand matrixes as a function of a future date, wherein the set of utility demand matrixes are classified by type-of-day, and representing a relation of past utility demand of the entity to time-in-day interval and outdoor temperature in the vicinity of the entity during the type-of-day; identifying a utility demand element from the utility demand matrix as a function of a future time-in-day and a known factor (e.g., future outdoor temperature) thereof; and generating a utility demand forecast of the entity for the future time period as a function of the identified utility demand element.

Abstract: A system, device, and corresponding method for enabling a user to accurately control, monitor, and evaluate performance of a vehicle. A portable programmable computer device that a user can readily install by plugging it into a diagnostic connector port of the vehicle. The system includes a detector for detecting the start time of first movement of the vehicle independent of the on board diagnostic system. Velocity data from the onboard diagnostic system is time stamped by a clock in the device and stored. Velocity curves are generated from the velocity data and time stamps. Wheel spin is accounted for by smoothing the velocity curve to determine a point of inflection in the velocity indicative of termination of wheel spin and creating correcting velocity and acceleration curves by solving equations from the inflection point backwards on the curve down to time zero. From the corrected curves, an accurate distance is calculated.

Abstract: Systems and methods for automatically transferring control from one air traffic control (ATC) center that uses one ATC data link standard to another ATC center that uses a different ATC data link standard are disclosed. In one embodiment, the system includes a receiver component configured to receive at least a new air traffic control center designation message from an original air traffic control center through an active connection, an identifier component configured to determine a data link standard of a new air traffic control center from the message, a logon component to log the aircraft into the new center. The system further includes a connection component to establish an inactive connection with the new air traffic control center, a confirmation component to confirm the inactive connection, and a switch component to terminate the active connection and activate the inactive connection.

Abstract: A system for aiding the piloting of an aircraft during a runway approach includes an information source that provides information relating to the aircraft and its environment. A computation unit determines, with the aid of information provided by the information source, an energy reference profile having a trajectory reference profile and a speed reference profile that allows the aircraft to regain a stabilized approach trajectory, if it follows the reference profile. A monitor verifies that the aircraft is following the reference profile. An indicator supplies the pilot with piloting indications for piloting the aircraft so as to follow the reference profile.

Abstract: A method of processing and displaying train performance including analyzing train data received from the train or train simulator real time or from a data storage and preparing display data of the results of the analysis. Computer graphic images are created from the display data; and the computer graphic images are provided for display. A display may be a drive with the display data and displayed portions of the display data may be selected to be created into computer graphic images. The computer graphic images may be transmitted over the internet or stored on a portable store and ultimately displayed on a video player. The computer graphic images may be viewed and edited or enhanced.

Abstract: A system is provided for regulating the speed of a rail vehicle traveling along a track. The track has a pair of rails. The system includes a temperature sensor positioned on an external surface of the rail vehicle. The temperature sensor measures a temperature of one of the rails. The system further includes a controller coupled to the temperature sensor. The controller receives data of the measured temperature, and regulates the speed of the rail vehicle based upon the measured temperature data. A method and computer readable media are also provided for regulating the speed of a rail vehicle traveling along a track.

Abstract: A watercraft can have a controller that can change a speed mode between a speed set mode and a regular mode in response to an operation of an auto cruise switch. The controller can return the speed mode to a regular mode under various conditions. For example, but without limitation, when an engine rotational speed reaches “zero” or nearly “zero” (i.e., an engine operation stops or nearly stops) while the speed mode is in the speed set mode. The controller can be configured to follow the actuation of the cruise switch only when the switch is operated in the regular mode.

Abstract: An obstacle-sensing system for carriers, particularly autonomous carriers such as robot vacuum cleaners, enables the carriers to disengage themselves from any obstacle or obstruction with which they come into physical contact and proceed past the obstacle or obstruction. The obstacle-sensing system is established by constructing a carrier to have front and rear sections which, normally, are in a neutral relationship with respect to one another but which move relative to one another when the front section physically engages an obstacle or obstruction. The relative movement activates a guidance and control system that maneuvers the carrier around the obstacle or obstruction.

Abstract: A method for error processing in electronic controllers, particularly, in motor vehicles, is provided whereby errors determined on each vehicle start are permanently written in an error memory. On repeated recognition of similar errors, an error counter, provided for the error, is increased. In the case where it is determined that the error counter has reached a pre-determined state on a renewed vehicle start, a special “poor maintenance” is launched, which only permits the start of the monitored function when further tests are carried out and completed.