Patents Issued in December 6, 2011
  • Patent number: D650136
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: December 6, 2011
    Inventor: Ronald Efrain Zabala-Goetschel
  • Patent number: D650137
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: December 6, 2011
    Inventor: Charles A. Byrne
  • Patent number: D650138
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: December 6, 2011
    Inventor: Danny Lavy
  • Patent number: D650139
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: December 6, 2011
    Inventor: Danny Lavy
  • Patent number: D650140
    Type: Grant
    Filed: July 7, 2010
    Date of Patent: December 6, 2011
    Assignee: CPA Pool Products, Inc.
    Inventors: Martin Rossano, Eric Quirion
  • Patent number: D650141
    Type: Grant
    Filed: January 5, 2011
    Date of Patent: December 6, 2011
    Assignee: Hannoa Oy
    Inventors: Ari Salonen, Ari Pöllänen
  • Patent number: D650142
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: December 6, 2011
    Assignee: Rubbermaid Incorporated
    Inventor: Robert Grant McRorie
  • Patent number: D650143
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: December 6, 2011
    Assignee: Demag Cranes & Components GmbH
    Inventors: Shrikant Bhosale, Mahesh Uttekar, Deepti Khadke, Deepak Desai, Akhoy Seal, Stefan Steinberg, Sven Müller
  • Patent number: D650144
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: December 6, 2011
    Assignee: Architectural Mailboxes, LLC
    Inventors: Christopher Andrew Farentinos, Vanessa Felicia Troyer-Farentinos, Emily Jeanne Pearson
  • Patent number: D650145
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: December 6, 2011
    Assignee: Architectural Mailboxes, LLC
    Inventors: Christopher Andrew Farentinos, Vanessa Felicia Troyer-Farentinos, Emily Jeanne Pearson
  • Patent number: H2265
    Abstract: A differential variable reluctance transducer (DVRT) is provided to measure a translation parameter, such as acceleration and/or deceleration of a test projectile. The DVRT, contained in a canister of the projectile, includes a cylindrical housing and an electronics module. The housing defines a cavity containing insulation and a bobbin around which a wire coil is wrapped. The housing has an attachment end and a distal end that faces the acceleration indicator. The bobbin is disposed substantially collinear to the housing. The wire coil is helically disposed around the bobbin. The insulation fills the remainder of the cavity. The electronics module receives electric current from the wire coil and connects to a data recorder.
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: December 6, 2011
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Timothy M. Fouse, Michael M. Canaday, Steven W. Mundell, John R. Bowen, Jr., Michael John Hamel
  • Patent number: PP22292
    Abstract: A new and distinct kiwifruit variety is disclosed. The variety results from selection among a population of seedlings derived from crossing the kiwifruit selections known as Kuimi 79-1-1 (not patented) and 30-03-05c.94 (not patented). The fruit of this new kiwifruit variety is characterized by moderate to large fruit size, high natural yield potential, ovoid shape, yellow flesh color, and potential for long storage. The new kiwifruit variety has been named ‘ZESY003’.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: December 6, 2011
    Assignee: Zespri Group Limited
    Inventor: Russell G. Lowe
  • Patent number: PP22293
    Abstract: A new and distinct Olea europaea L. olive tree variety named ‘ASKAL’, particularly characterized by a medium-sized tree with vigorous growth, high fruit yield, field resistance to Spilocaea oleagina, mature fruit with average commercial oil content of 23.5% on fresh weight basis under irrigation, a well-balanced fruity-grassy taste, good stability (7.8 h at 1100C), high oleic acid content of about 72% and good polyphenol content (233 mg/kg).
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: December 6, 2011
    Assignee: State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization
    Inventors: Shimon Lavee, Benjamin Avidan, Yair Manni
  • Patent number: PP22294
    Abstract: A new and distinct variety of peach tree, denominated ‘UFSharp’, has a low winter chilling requirement estimated at 325 chill units (cu). The tree is of medium size, has a moderate vigorous and upright growth habit. It has showy, pink flowers, and leaves with globose glands. Trees of ‘UFSharp’ are self-fertile and regularly bear heavy annual crops of early, mid-season fruit that are large for its ripening season. Fruit are uniformly firm and yellow with non-melting flesh which are clingstone. Fruit are oval, and uniform with substantially symmetrical shape, and have an attractive 50 to 70% bright red skin. The fruit of ‘UFSharp’ ripens about 6 days after ‘UF2000’ peach in late May at Gainesville, Fla.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: December 6, 2011
    Assignee: Florida Foundation Seed Producers, Inc.
    Inventor: Jose X. Chaparro
  • Patent number: PP22295
    Abstract: A new distinct variety of grapevine named ‘ARRATHIRTEEN’ abundantly forms attractive large seedless berries having a fire red skin coloration in medium-to-large clusters. The fruit displays a sweet crisp flavor and is firm in texture. The fruit commonly is ready for harvesting during the end of June in San Joaquin Valley of Central California, U.S.A, and displays good eating qualities as a table grape. The fruit firmness renders the fruit well amenable for handling, shipping, and storage.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: December 6, 2011
    Assignee: Agricultural Research and Development Limited Liability Company
    Inventors: Shachar Karniel, Sal Giumarra
  • Patent number: PP22296
    Abstract: ‘Jantar’ is a new Thuja variety particularly distinguished by being a medium-sized evergreen shrub, having a medium growth rate, an upright narrow, pyramidal plant habit with pointed tip, dense foliage with leaves held tightly, trunk and twigs completely hidden, and bright amber-yellow to medium-yellow foliage is disclosed.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: December 6, 2011
    Inventor: Jacub Jablonski
  • Patent number: PP22297
    Abstract: Cercis ‘Merlot’ is a new and distinct variety of redbud that has the following unique combination of desirable features that are outstanding in a new variety. 1. Moderate vigor resulting in moderate plant size. 2. Ease of asexual propagation using chip-budding. 3. Semi-upright growth habit. 4. Emerging foliage with deep purple color, transitioning to burgundy and eventually green during the growing season. 5. Glossy leaf surface. 6. Bright lavender flowers produced in abundance during the spring. 7. Low female fertility resulting in reduced pod set.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: December 6, 2011
    Inventors: Dennis James Werner, Layne Karlton Snelling
  • Patent number: PP22298
    Abstract: An Eastern Redbud tree named ‘JN3’ having golden orange new growth and specked lime green mature foliage with a wavy, rugose dark green margin and also capable of being reproduced reliably from chip budding.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: December 6, 2011
    Inventors: Ray Jackson, Cindy Jackson
  • Patent number: PP22299
    Abstract: A new and distinct cultivar of Mandevilla plant named ‘VOG 051’, characterized by its compact, upright and mounding plant habit; strong stems; freely flowering habit; and dark greyed purple-colored flowers.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: December 6, 2011
    Assignees: Floraquest Pty. Ltd., Protected Plant Promotions Australia Pty. Ltd.
    Inventor: Graham Noel Brown
  • Patent number: PP22300
    Abstract: The new and distinct plant cultivar of hardy Hibiscus named ‘Sultry Kiss’ comprising heavily branched purple tinted stems containing three-lobed maple-like foliage with burgundy tinting, and flowers with heavily overlapped magenta red petals and crimson red eye, over at least 12 weeks during the summer and early fall until frost.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: December 6, 2011
    Assignee: Walters Gardens, Inc.
    Inventor: Kevin A. Hurd
  • Patent number: PP22301
    Abstract: A new and distinct cultivar of Hibiscus plant named ‘DUP-HDEF’, characterized by glossy, dark green leaves, semi-upright habit appropriate for container production and culture, freely flowering habit, and very large flowers having a deep red eye zone, a silver lilac body and beige edges.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: December 6, 2011
    Inventor: Robert J. Dupont, Sr.
  • Patent number: PP22302
    Abstract: A new and distinct cultivar of Achillea plant named ‘Pineapple Mango’, characterized by its upright, columnar and mounding plant habit; strong and vigorous growth habit; freely branching habit; freely flowering habit with plants remaining in flower for a long period time; inflorescences with pink-colored ray florets that become yellow with development; and good garden performance.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: December 6, 2011
    Assignee: K. Sahin Zaden B.V.
    Inventor: Wilhelmus J. J. Nijssen
  • Patent number: PP22303
    Abstract: A new and distinct Anemone plant named ‘Pretty Lady Emily’ having a compact growth habit and large light pink-colored semi-double flowers.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: December 6, 2011
    Assignee: Walter Blom Plants N.V.
    Inventor: Yoshihiro Kanazawa
  • Patent number: PP22304
    Abstract: A new cultivar of Polygonatum named ‘Prince Charming’ characterized by its height of about 30 cm (12 inches), its heavy and early blooming habit, its ability to bloom as a young plant, and its pronounced ridge (ligule) at the point of stem attachment on the lower leaf surface
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: December 6, 2011
    Inventors: Brent A. Horvath, Therese LaLonde Horvath
  • Patent number: PP22305
    Abstract: A new Chrysanthemum plant named ‘Syncin Pueblo’ particularly distinguished by the greyed-orange ray floret color with mostly green discs at the early age, single, daisy-type flowers, strong stems, good shelf-life, medium green foliage, uniform plant habit and flowering response time, and about an 8 week flowering response time.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: December 6, 2011
    Assignee: Syngenta Crop Protection AG
    Inventor: Wendy R. Bergman
  • Patent number: PP22306
    Abstract: A new and distinct cultivar of Alstroemeria plant named ‘Zalsails’, characterized by its erect and strong flowering stems; vigorous growth habit; red-colored flowers; and excellent postproduction longevity.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: December 6, 2011
    Assignee: Van Zanten Plants b.v.
    Inventor: Henricus Cornelius Maria Jacobs
  • Patent number: PP22307
    Abstract: A new and distinct cultivar of Alstroemeria plant named ‘Zalsasol’, characterized by its erect and strong flowering stems; vigorous growth habit; bright yellow-colored flowers; and excellent postproduction longevity.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: December 6, 2011
    Assignee: Van Zanten Plants b.v.
    Inventor: Henricus Cornelius Maria Jacobs
  • Patent number: PP22308
    Abstract: A new and distinct cultivar of Alstroemeria plant named ‘Zalsalyn’, characterized by its erect and strong flowering stems; vigorous growth habit; pink-colored flowers; and excellent postproduction longevity.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: December 6, 2011
    Assignee: van Zanten Plants b.v.
    Inventor: Henricus Cornelius Maria Jacobs
  • Patent number: PP22309
    Abstract: A new and distinct Antirrhinum cultivar named ‘AACYE04’ is disclosed, characterized a compact, mounding plant habit, flexible stems and distinctive yellow. The new variety is an Antirrhinum, typically produced as a garden or container plant.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: December 6, 2011
    Inventor: Graham Nofu Brown
  • Patent number: PP22310
    Abstract: A new and distinct Petunia cultivar named ‘DANLITT248 ’ is disclosed, characterized by having a distinctive small, white flowers, and a compact, rapid growth habit. The new variety is a Petunia, normally produced as an outdoor garden or container plant.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: December 6, 2011
    Inventor: Gavriel Danziger
  • Patent number: PP22311
    Abstract: A new cultivar of Miscanthus, Miscanthus sinensis ‘Gold Breeze’, that is characterized by its stiff leaf blades that are densely banded with alternating bands of creamy yellow and apple green with the banding consistent from the base to the tip of the leaf blade, its moderate plant height, its upright plant habit with foliage that is dense and bushy and resists lodging, and its late season bloom of bright purple-red inflorescences in late September to early October in Oregon.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: December 6, 2011
    Inventors: Michael Vern Smith, Maurice R. Horn, Scott Christy
  • Patent number: PP22312
    Abstract: A new Calibrachoa plant named ‘Calpribul’ particularly distinguished by the relatively large sized, violet colored flowers, medium green foliage and compact plant habit with good branching
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: December 6, 2011
    Assignee: Syngenta Crop Protection AG
    Inventor: Theodorus Cornelis van Kleinwee
  • Patent number: PP22313
    Abstract: A new and distinct Heucherella plant substantially as shown and described, characterized by its trailing habit combined with yellow spring leaves to lime green summer and winter leaves, a dark splatter pattern on the veins, medium palmately lobed leaves, and good vigor.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: December 6, 2011
    Assignee: Terra Nova Nurseries, Inc.
    Inventor: Janet N. Egger
  • Patent number: PP22314
    Abstract: A new and distinct Sutera cordata plant named ‘DANOVA886’ particularly characterized by 5-petalled flowers, measuring 2.3 cm in diameter and violet-blue in color with a yellow colored throat; semi-trailing, compact growth habit; early flowering response; and suitable for use with hanging basket planters, combination planters and ground cover under full sunlight-and slight shade.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: December 6, 2011
    Inventor: Gavriel Danziger
  • Patent number: RE42985
    Abstract: The invention relates to a toothbrush having a handle and a head part, on which bristle filaments and at least one flexible cleaning element are arranged. According to the invention, the at least one flexible cleaning element is arranged on a carrier element which consists of a hard material and is connected to the head part. The invention also relates to a process for producing such a toothbrush.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: December 6, 2011
    Assignee: Trisa Holding AG
    Inventors: Franz Fischer, Reto Strahler
  • Patent number: RE42986
    Abstract: A bicycle disc brake hub is provided with a brake rotor attachment portion having an external surface with an external spline section and an annular internal surface with internal threads, and a locking ring having a center tubular section with external threads and an abutment flange extending outwardly from the center tubular section to form an axially facing retaining surface. The external threads of the center tubular section mates with the internal threads of the brake rotor attachment portion to secure a rotor mounting boss and a brake rotor thereto. In one embodiment, the brake rotor is held between the locking ring and the rotor mounting boss, while in a another embodiment, the brake rotor is riveted to the rotor mounting boss.
    Type: Grant
    Filed: January 22, 2003
    Date of Patent: December 6, 2011
    Assignee: Shimano Inc.
    Inventor: Takanori Kanehisa
  • Patent number: RE42987
    Abstract: A nail gun has a free end 19a and central potion of a trigger arm 19 positioned within a trigger 11, on an upper end 12a of a safety portion 12 and at a plunger 17, respectively. When the trigger 11 is pivoted on its pivot end 16, pivoting movement of the trigger 11 moves a pivot end 18 of the trigger arm 19 to press the central portion of the trigger arm 19 into contact with the plunger 17 and, with the plunger 17 serving as a fulcrum, to press the free end 19a downward against the upper end 12a of the safety portion 12. If downward movement of the safety portion 12 is obstructed when the trigger 11 is pivoted, the upper end 12a contacted by the free end 19a of the trigger arm 19 serves as a fulcrum around which the trigger arm 19 pivots with movement of the trigger 11, whereupon the central portion of the trigger arm 19 presses the plunger 17 inward so that an activation switch 10 activates a blade 7 to eject a nail through a nose piece 5.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: December 6, 2011
    Assignee: Hitachi Koki Co., Ltd.
    Inventor: Yoshitaka Akiba
  • Patent number: RE42988
    Abstract: The wire stand of the present invention includes an upper rim of wire steel in a substantially rectangular configuration, a lower rim of wire steel of similar configuration and a pair of wire legs with each formed as an integral unit with each wire leg affixed at one end thereof to the upper rim and affixed to the lower rim such that the upper rim and lower rim lie in substantial parallel alignment to one another and extending below the lower rim to maintain the lower rim a fixed distance above the support upon which the stand is placed.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: December 6, 2011
    Inventor: Robert Skvorecz
  • Patent number: RE42989
    Abstract: A method for applying a liquid composition to a rail surface is provided. This method involves supplying a liquid composition in one or more reservoirs on a rail car (revenue generating car), and applying the liquid composition from the one or more reservoirs to the rail surface.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: December 6, 2011
    Assignee: Kelsan Technologies Corp.
    Inventors: Don Eadie, John Cotter, Dave Elvidge
  • Patent number: RE42990
    Abstract: An alternator pulley includes a driving member driven and rotated via a belt from an output shaft of an engine. A driving member is disposed on an inner surface of the driving member and a one-way clutch is interposed between the driving and driven member. The one-way clutch includes rollers capable of rolling in a locked side direction along which a rotating power of the driving member is transmitted to the driven member or a free side direction along which the rotating powder is interrupted. Depending on a relative speed difference between the driving member and the driven member, the rollers are biased for pressing in the locked side direction and a torque value of the pressing is set preferably to less than 4 Nm.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: December 6, 2011
    Assignee: JTEKT Corporation
    Inventor: Yasuhito Tanaka
  • Patent number: RE42991
    Abstract: A door alarm system is provided which activates an alarm when a door (such as the door to the patient's room, a bathroom door within the patient room, etc.) is closed with something (such as a sheet, cord or the like) over the top of door.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: December 6, 2011
    Assignee: The Door Switch
    Inventor: Francis E. Cook
  • Patent number: RE42992
    Abstract: A compact chromatic display system to be used by a viewer to view a virtual image including: (a) an output optical device, which enables the viewer to see through it a chromatic virtual image. (b) an input optical device. (c) an optical arrangement for directing light from the input optical device to the output optical device and (d) a Shift Adjusted Display (SAD) device that radiates chromatic image.
    Type: Grant
    Filed: September 4, 2007
    Date of Patent: December 6, 2011
    Assignee: Mirage Innovations Ltd.
    Inventor: Yair David
  • Patent number: RE42993
    Abstract: A liquid crystal driver includes a voltage generator for generating gray scale voltages on the basis of reference voltages, and an output device for selecting one gray scale voltage from the generated gray scale voltages in accordance with display data, for applying inversion/non-inversion control to the selected gray scale voltage with respect to an inversion reference voltage on the basis of the selected gray scale voltage, an AC switching signal and the inversion reference voltage, and for outputting different liquid crystal supply voltages for one and the same display data to a liquid crystal panel.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: December 6, 2011
    Assignee: Hitachi, Ltd.
    Inventors: Hiroyuki Nitta, Hiroyuki Mano, Tsutomu Furuhashi, Isao Takita, Satoru Tsunekawa, Toshio Futami, Makiko Ikeda
  • Patent number: RE42994
    Abstract: A method for replacing parts of a digitally coded picture (11) is proposed. The digitally coded picture (11) may correspond to a sub-picture which is displayed on the screen of a television set (10). In the method, each line of the picture (11) is run length-coded. The replaceable parts of a line of the picture are run length-coded separately. The part which replaces the replaceable, original part of a line of the picture (11) is run length-coded in such a way that it has the same number of data units (data bytes) as the original part of this line of the picture (11). The replacement of the data for the run length coding words is carried out in a memory device (51). The replacement is possible in a simple manner by virtue of the fact that the original part of a line of the picture and the new part of the line of the picture have the same number of data units. Moreover, a device for carrying out the method is also proposed.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: December 6, 2011
    Assignee: Thomson Licensing
    Inventor: Marco Winter
  • Patent number: RE42995
    Abstract: An embodiment of the present invention includes a fax communication system for communicating fax information transmitted from a sending fax device to a fax recipient through a packet switching network. The sending fax device includes a data pump for modulating and demodulating fax information and a protocol subsystem for encoding and decoding the modulated fax information. The fax sending fax device modulates the fax information prior to transmission thereof. At least one access server is coupled between the sending fax device and the fax recipient and within the packet switching network At least one of the access servers receives modulated fax information from the sending fax device and demodulates the received fax information.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: December 6, 2011
    Assignee: Cisco Technology, Inc.
    Inventors: Neil Raymond Joffe, Ilya Umansky
  • Patent number: RE42996
    Abstract: Disclosed are an SIP-based user mobility service providing apparatus and method using user position information obtained by a sensing apparatus. When a user enters a specific region, a gateway including a sensing management module carries out SIP registration for several terminals existing in the specific region in place of user agents of the terminals. The sensing management module transmits an SIP registration message to an SIP proxy server and notifies the terminals of the completion of SIP registration. Then, the user receives a call using the same kind of a terminal as a specific terminal previously set on the basis of a user's preferences among the terminals in the specific region.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: December 6, 2011
    Assignee: Pantech Co., Ltd.
    Inventors: Eun-Hee Hyun, Young-Jick Bahg
  • Patent number: RE42997
    Abstract: The present invention provides system and method for delayed answering of a call to a cellular phone which can operate in either a distributed or a centralized manner. In particular, the system and method according to the present invention allows the cellular phone user upon receiving a call to play a message to the caller, such as informing the caller to “hold on” for a short time and that the user will be available shortly. The present invention provides a number of advantageous alternatives to provide a cellular phone user flexibility in answering incoming calls.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: December 6, 2011
    Assignee: TTI Inventions C LLC
    Inventor: John R. Wullert, II
  • Patent number: RE42998
    Abstract: The present invention relates to improved ophthalmic diagnostic measurement or treatment methods or devices, that make use of a combination of a high speed eye tracking device, measuring fast translation or saccadic motion of the eye, and an eye position measurement device, determining multiple dimensions of eye position or other components of eye, relative to an ophthalmic diagnostic or treatment instrument.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: December 6, 2011
    Assignee: Sensomotoric Instruments Gesellschaft fur Innovative Sensorik mbH
    Inventors: Winfried Teiwes, Horia Grecu
  • Patent number: RE42999
    Abstract: The present invention provides a method for measuring the self-consistency of inference algorithms. The present invention provides a method for measuring the accuracy of an inference algorithm that does not require comparison to ground truth. Rather, the present invention pertains to a method for measuring the accuracy of an inference algorithm by comparing the outputs of the inference algorithm against each other. Essentially, the present invention looks at how well the algorithm applied to many of the different observations gives the same answer. In particular, the present invention provides a method that is not time and labor intensive and is cost effective.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: December 6, 2011
    Assignee: Transpacific Kodex, LLC
    Inventors: Yvan G. LeClerc, Margaret Frances Davies, legal representative, Quang-Tuan Luong, Pascal Fua
  • Patent number: RE43000
    Abstract: The present invention relates to riboswitches that have been engineered to regulate pre-mRNA splicing. In particular, the insertion of a high affinity theophylline binding aptamer into the 3? splice site region, 5? splice site region, or branchpoint sequence (BPS) of a pre-mRNA modulates RNA splicing in the presence of theophylline. Accordingly, the aspects of the present invention include, but are not limited to, theophylline-dependent riboswitches which modulate RNA splicing, methods of modulating RNA splicing using theophylline and its corresponding riboswitches, methods of improving/identifying theophylline-dependent riboswitches, methods of treating diseases associated with or caused by abnormal RNA splicing.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: December 6, 2011
    Assignee: City of Hope
    Inventors: Rajesh K. Gaur, Sailesh Gopalakrishna Pillai