Abstract: A surgical device is provided that includes a jaw portion with a first jaw and a second jaw moveable relative to the first jaw. The surgical device also includes a shaft portion coupled to a proximal end of the jaw portion. A driver is configured to cause relative movement of the jaw portion and the shaft portion. The driver may be configured to cause the jaw portion to pivot relative to the shaft portion about a pivot axis that is perpendicular to first and second longitudinal axes defined by the jaw portion and the shaft portion, respectively. The driver may also be configured to cause at least a portion of the jaw portion to rotate relative to the shaft portion about the first longitudinal axis. Advantageously, the surgical device includes a surgical member, e.g., a cutting element and/or a stapling element, disposed within the first jaw.

Abstract: A tissue closing device for closing an opening penetrating a tissue membrane in a living body includes a closure configured to close the opening and a device configured to deploy the closure. The closure includes a seal portion and a deformation portion for covering the opening and tissue membrane surrounding the opening from opposite sides, and a connecting portion connecting the seal portion and the deformation portion. The arrangement device includes a storing member for storing the deformation portion and supporting the connecting member, and a hand-operated portion on the proximal side of the storing member. The storing member includes a take-out port which is openable from a closed state. The deformation portion is discharged exterior of the storing member by opening the take-out port.

Abstract: The present invention relates to the use of a low frequency ultrasonic device for the delivery and activation of collagen based foam sealants to a human and/or animal patient for sealing puncture wounds in vascular tissues. The ultrasonic vascular closure device comprises an ultrasonic generator, an ultrasound transducer, a chamber containing a foam sealant, a transducer tip, a radiation surface, an orifice located at the distal end of the chamber. The foam sealant is ejected into a puncture wound and activated with ultrasonic waves emitting from the radiation surface. The ultrasonic waves induce vibrations within the foam sealant, slightly warming the foam sealants to assist the rapid sealing the puncture. The ultrasonic waves also provide and anesthetic effect for the pain and discomfort from the puncture site.

Abstract: Devices and methods for accessing and closing vascular sites are disclosed. Self-sealing closure devices and methods are disclosed. A device that can make both steeply sloping and flat access paths into a vascular lumen is disclosed. The device can also form arteriotomies with sections cleaved between a vessel's intima and adventitia. Methods for using the device are also disclosed.

Abstract: A surgical tack is provided that can have a single shaft formed of a bio-compatible material and a tip adapted for entering and engaging bone or tissue; and a head mounted on said shaft.

Abstract: An integral display for a child's pacifier indicates whether it is clean and safe for the child's use. The pacifier has a selectable dial on its exterior rear face that allows the care-giver to select between “CLEAN” or “DIRTY”, depending on the status of the pacifier. Once the pacifier is properly cleaned, the care-giver would slide the indicator to display “CLEAN”. In such a manner, the care-giver would always be aware of the cleanliness of the pacifier and whether it would be safe to give to the child.

Abstract: A device for introduction into a body in a straight configuration and assuming within the body a predefined curved configuration, includes an elongated element formed from a number of segments interconnected so as to form effective hinges therebetween. When the elongated element is confined to a straight state, the effective hinges transfer compressive forces from each segment to the next so that the elongated element can be pushed to advance it through a conduit. When the elongated element is not confined to a straight state, the effective hinges allow deflection of each segment relative to adjacent segments until abutment surfaces of the segments come into abutment, thereby defining a fully flexed state of the elongated element with a predefined curved configuration. The device can be produced with a wide range of two-dimensional and three-dimensional curved forms, and has both medical and non-medical applications.

Abstract: Methods and devices are adapted to limit the extent of vertebral extension between an upper-most vertebral bone and a lower-most vertebral bone wherein a least one additional vertebral bone resides between them. In an embodiment, the limitation of extension occurs while flexion is at least partially maintained within at least one FSU. In other embodiments, flexion may be abolished.

Abstract: The present invention provides spinous process implant and associated methods. In one aspect of the invention the implant limits the maximum spacing between the spinous processes. In another aspect of the invention, a spacer has at least one transverse opening to facilitate tissue in-growth. In another aspect of the invention, an implant includes a spacer and separate extensions engageable with the spacer. The spacer is provided in a variety of lengths and superior to inferior surface spacings. In another aspect of the invention, an implant includes a spacer and a cerclage element offset from the midline of the spacer in use so that the spacer defines a fulcrum and the cerclage element is operative to impart a moment to the vertebrae about the spacer. In another aspect of the invention, instrumentation for inserting the implant is provided. In other aspects of the invention, methods for treating spine disease are provided.

Abstract: A spinal implant including first spinal attachment member for attaching to a first spinal portion, second spinal attachment member for attaching to a second spinal portion, and a post-implantation variable dimension device disposed between the first and second spinal attachment members, which is operable after completing surgery in which said spinal implant was installed into a patient, to cause relative movement between the first and second spinal attachment members.

Abstract: The invention concerns a distance-keeping inter-process implant with a body (1) ending in its posterior part with two opposite-situated resistance protrusions (2). In the anterior part of the body (1) there are situated at least two wings (5, 6), at least one of which is a mobile wing (6) connected with the body (1) by an articulated joint. Each wing (5, 6) is provided with at least one guide (11, 13, 14, 15) of the tensioning band (4). The articulated joint between the mobile wing (6) and the body (1) is formed by the mutually collaborating shaped surface (7) of the. wing (6) and the shaped surface (8) of the body (1) and is usefully secured by the pin (12) that constitutes the axis of rotation of the mobile wing (6). In an alternative version of the implementation of the implant, the mobile wing (6) connected with the body (1) is provided with at least one arm (16) situated with respect to the wing (6) at the angle ? amounting to from 30° to 150°.

Abstract: A polyaxial bone screw includes a head member and a shank member. The shank has a capture end and an opposite threaded end for threaded insertion into a vertebra. The head has a U-shaped cradle for receiving a spinal fixation rod and a central bore for receiving the capture end of the shank. An expandable retainer ring with a radial split is snapped onto the capture end of the shank to retain it within the head. The retainer ring has a spherical outer surface which forms a ball joint with a spherical socket cavity within the head to enable the head to be angled relative to the shank. A threaded closure plug is tightened within the cradle to clamp the rod into engagement with a knurled dome on the capture end of the shank to secure the rod relative to the vertebra.

Abstract: A spinal cross-connector is configured for adjustable connection between spinal fixation devices such as spinal fixation rods and allows for adjustment in length or distance between adjacent spinal rod clamping members and provides independent rotational adjustment of the two spinal rod clamping members for individual and independent attachment thereof to adjacent spinal rods of a spinal rod assembly. The cross-connector has first and second connection members that are adjustable in length and rotation relative to one another. A first spinal rod clamping member is provided on an end of the first connection member and defines first and second arced jaws that are adapted to clamp onto a first spinal rod. A second spinal rod clamping member is provided on an end of the second connection member and defines first and second arced jaws that are adapted to clamp onto a second spinal rod.

Abstract: The invention provides instruments and methods for prophylactic treatment of an osteoporotic vertebral body or for treating a vertebral compression fracture (VCF). In one exemplary method, a probe system uses a high speed rotational elastomeric cutter having an optional expandable abrasive surface for abrading or cutting at least one path or region within vertebral cancellous bone. Irrigation and aspiration sources are included in the probe system for removing abraded bone debris. In one embodiment, the high speed rotational abrader uses a tissue-selective abrading surface that abrades or cuts bone but does not cut soft tissue. In another embodiment, an expandable abrading surface allows the treatment of bone with low pressures to create paths or spaces without explosive expansion forces known in prior art balloon procedures that are designed to crush and compact cancellous bone in a vertebra.

Abstract: Craniotomy closure systems comprising surgical fasteners and a protective covering over the dura are described for use in reattaching a skull flap removed from the skull of a patient during brain surgery. Methods of using the same are also described. Surgical strips optionally used in combination with the craniotomy closure systems are shaped to follow the perimeter contour of the skull flap. The craniotomy closure systems are designed to encourage bone growth and healing of the skull flap and they can be used to deliver medication and bone growth enhancement materials to the surgical site.

Abstract: Methods and systems for occipital-cervical spinal fixation. A plate configured for attachment to the occipital bone has two arms extending out from either side, which turn downwards parallel to one another. A first bend is disposed in the arms, such that the arms extend down from the occipital bone behind the spinous process of the C1 and C2 vertebrae, upon installation. A second bend in the arms allows attachment to the C2 vertebra. The system may be dimensioned for pediatric installation. A bone graft material may be held in place between the cervical vertebrae and the skull by installing a cable to the installed system to retain the bone graft material in place. Methods and kits for occipital-cervical spinal fixation are also disclosed.

Abstract: Removable drill guide tips are pre-assembled into threaded holes of a bone plate. The tips may be used with an extension to together function as a conventional drill guide. After drilling, the extension or another tool is used to remove the tips from the plate. According to another use, the tip is used as a guide for a drill bit without any additional extension and then removed with a tool.

Abstract: In an exemplary embodiment, the present invention provides an anchor assembly that can be used for the fixation or fastening of orthopedic devices or instruments to bone tissue. In particular, the present invention preferably provides a variable angle or fixed angle anchor assembly that is able to securely connect the orthopedic device to bone tissue even when there is a variance in the angle and position of the assembly with respect to the device. Furthermore, in an exemplary embodiment, the present invention provides an anchor assembly having a locking mechanism that will quickly and easily lock the anchor assembly with respect to the orthopedic device.

Abstract: A bone anchor system anchors a support member to a bone. The bone anchor system comprises a body having a shank adapted for insertion into a hole in the bone. A head is formed on the shank. The head has a support engagement portion adapted to secure the support member to the body. A passage extends from an entry point to an exit point formed in the body. An expandable member has a flexible wall at least partially enclosing an anchoring chamber. The expandable member has an expanded state configured to conform to a cavity in the bone. The anchoring chamber is in fluid communication with the exit point. The expandable member is adapted to expand when a filler material is provided into the anchoring chamber. A portion of the expandable member conforms to the cavity and the body and the support member are substantially anchored to the bone.

Abstract: Pedicle screws that can include a pedicle screw body, housing, plurality of clamps, rod, and set screw are disclosed herein. The clamps may be positioned side by side inside the lower portion of the housing. When the rod and set screw are provided in the housing, the set screw applies a force on the rod and the rod engages the plurality of clamps, causing the clamps to frictionally engage a head of the pedicle screw between the clamps.

Abstract: A flexible clamp for plugging an aperture in a bone, including a plurality of flexible anchoring members, where each flexible anchoring member has a first end and a second end opposite the first end; a locking tab connected to the second end of each flexible anchoring member; and, a stabilization member slidingly engagable with the flexible anchoring members, wherein the stabilization member may be translocated from a position adjacent the first ends of the flexible anchoring members to a clamping position adjacent the second ends of the flexible anchoring members. The locking tabs engage an inner surface of the bone and the stabilization member engages an outer surface of the bone when in the clamping position. The flexible clamp further includes a ratcheting mechanism associated with each flexible anchoring member, and a plurality of pawl mechanisms formed within the stabilization member which lockingly engage with each of the ratcheting mechanisms.

Abstract: A lighting device for use as a visual indicator in a medical probe is provided. The lighting device includes one or more light emitting elements that are used as a visual status indicator for the medical probe, and a driver circuit that receives current from a power source and drives the light emitting elements. The driver circuit includes a current sensor to sense a current flowing through the light emitting elements, and a shut off switch. The shut off switch shuts off the power source current from the light emitting elements based on the sensed current from the current sensor.

Abstract: An implant delivery catheter enables permanent modification of the implant length in the vicinity of the treatment site prior to radial expansion thereof. The implant is releasable carried between inner and outer tubular members of the delivery catheter which, upon repositioning relative to one another using an actuator mechanism, impart any of tensile, compressile or torquing forces to the implant causing permanent modification of the implant length. In one embodiment, the circumference of the implant is substantially similar both before and after modification of the implant length. In another embodiment, the implant includes a plurality of strut sections interconnected by bridges which are capable of the deformation along the longitudinal axis of the implant.

Abstract: A stent delivery system comprises a stent having a first connector disposed on a stent proximal end, and a pusher wire having a second connector disposed on a pusher wire distal end, wherein the first and second connectors are configured to releasably attach to each other.

Abstract: A flexible low profile delivery system for delivery of an expandable intracorporeal device, specifically, an endovascular graft, which has at least one belt circumferentially disposed about the device in a constraining configuration. The belt is released by a release member, such as a release wire, by retracting the wire from looped ends of the belt. Multiple belts can be used and can be released sequentially so as to control the order of release and placement of the endovascular graft. An outer protective sheath may be disposed about the endovascular graft while in a constrained state which must first be refracted or otherwise removed prior to release of the graft from a constrained state. The delivery system can be configured for delivery over a guiding device such as a guidewire. The delivery system can also be configured for delivery of bifurcated intracorporeal devices.

Abstract: A medical supporting implant, in particular a stent, comprises a tubular base body which is made up of bendable struts (2), such that at node points (4) of at least two struts (2), the bendable struts (2) form an acute angle (W) to one another which angle becomes larger on dilatation of the implant with plastic deformation of the struts (2) at the node point (4). At least a portion of the struts (2) between the plastic deformation areas (4) is provided with a telescoping ratchet mechanism (R) for irreversible lengthening of the respective struts (2) on dilatation.

Abstract: An expandable stent is implanted in a body lumen, such as a coronary artery, peripheral artery, or other body lumen for rupturing a fibrous cap to controllably release vulnerable plaque. The invention provides for a an intravascular stent having a plurality of cylindrical rings connected by links. The stent includes struts and links of varying strengths about the circumference of the stent. The weaker struts and links require less force to open and, hence, may apply more stress to rupture the fibrous cap while the stronger struts and links protect the healthy portions of the body lumen. In another embodiment, the stent may include stress concentrators positioned on outer surfaces of the links. The stress concentrators are aligned with the fibrous cap prior to stent expansion so that upon stent expansion, the stress concentrators induce stress to rupture the fibrous cap, thereby releasing the vulnerable plaque.

Abstract: The present invention concerns novel stent apparatuses for use in treating lesions at or near the bifurcation point in bifurcated cardiac, coronary, renal, peripheral vascular, gastrointestinal, pulmonary, urinary and neurovascular vessels and brain vessels. More particularly, the invention concerns a stent apparatus with at least one side opening which may further comprise an extendable stent portion laterally extending from the side opening and at least partly in registry with the wall of the side opening.

Abstract: An endoluminal prosthesis including a radially expandable frame and an anchoring member. The anchoring member includes a first arm attached to a first strut of the frame and a second arm attached to a second adjacent strut of the frame. The first arm is joined to the second arm to form a vessel engaging end that, together with at least a portion of the first arm and second arm, is directed toward a central axis of the frame in the frame's collapsed configuration.

Abstract: Apparatus is provided that is configured to be implanted in a body of a subject, comprising an implant structure having first and second portions thereof, a spool coupled to the implant structure in a vicinity of the first portion thereof, and a flexible member coupled at a first end thereof to the spool, and not attached at a second end thereof to the spool. The flexible member, in response to rotation of the spool in a first direction thereof, is configured to be wound around the spool, and, responsively, to pull the second end of the flexible member toward the first end of the implant structure, and responsively to draw the first and second portions of the implant structure toward each other. Other embodiments are also described.

Abstract: Provided herein are embodiments of a weighted eyelid closure device for use in treating lagophthalmos. In accordance with an embodiment, the device can be implanted by an oculoplastic surgeon into a patient's eyelid, to treat lagophthalmos. The device's weight can then be adjusted later by the surgeon, if necessary, without requiring removal of the entire device. For example, if it is discovered that an implanted device is too heavy or too light after it has been implanted within the patient's eyelid, the load of the device can be adjusted by modifying the previous load. Alternatively, a new load having the desired weight can be implanted.

Abstract: Implantation of an accommodating intraocular lens in an eye may require the accurate measurement of the size, circumference, or diameter of the capsular bag of the eye. A flexible ring or ring portion may be temporarily or permanently inserted into the capsular bag for measuring the circumference of the capsular bag, for example, after extraction of a natural lens from the capsular bag. The ring or ring portion is generally compressible to fit through a surgical incision, then expands to fill the capsular bag along an equatorial region. The ring or ring portion includes a central component that changes shape and/or angle as the ring or ring portion is compressed. The shape change is generally correlated to the size of the capsular bag and may be visually measured through the cornea, the measurement being generally independent of corneal magnification. The measurement may be used to determine or calculate information about the capsular bag such as its size, elasticity, accommodative range, and so forth.

Abstract: In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).

Abstract: A haptic is provided for use in an accommodating intraocular lens. The haptic has multiple filaments, each connected to the edge of the optic at one end. Each filament has a shape that conforms to an equatorial region of the capsular bag. The haptic couples the forces exerted by the capsular bag of the eye during accommodation radially to the edge of the optic, produce a diametric expansion or compression of the optic. This diametric motion distorts the optic, producing a change in any or all of the anterior radius, the posterior radius, and the thickness. These changes affect the power of the lens and/or location of the image. The haptic may optionally have a thin membrane joining the filaments at the optic end, and may optionally have a connecting ring that joins the filaments at the end opposite that of the optic.

Abstract: A method and apparatus for treating a nasal valve condition including surgically forming an access path to create a pocket on a side of the patient's nose. The pocket is positioned between a soft tissue layer and opposing surfaces of upper and lower cartilages of the nose. The pocket spans a junction between the upper and lower cartilages. An implant is placed through the access path into the pocket with a length oriented to span the junction. A delivery system for placement of the implant includes a surgical tool for forming the access path and for delivering the implant into the access path.

Abstract: An implantable prosthesis system including a selectively applied bone growth promoting agent is disclosed. The types of prostheses which may include a selectively applied bone growth promoting agent include rods, fracture plates, screws, as well as other types of prostheses. Additionally, the structural composition of many types of prostheses may be modified to help induce bone ingrowth and allow for fusion with the implantable prosthesis.

Abstract: A radially expandable spinal interbody device for implantation between adjacent vertebrae of a spine is deliverable to an implant area in a radially collapsed state having minimum radial dimensions and once positioned is then radially expandable through and up to maximum radial dimensions. The expanded radially expandable spinal interbody device is configured to closely mimic the anatomical configuration of a vertebral face. The radially expandable spinal interbody device is formed of arced, pivoting linkages that allow transfiguration from the radially collapsed minimum radial dimensions through and up to the radially expanded maximum radial dimensions once deployed at the implant site (i.e. between adjacent vertebrae). The pivoting linkages have ends with locking features that inhibit or prevent overextension of the linkages.

Abstract: This present invention concerns a transforaminal intersomatic cage for an intervertebral fusion graft, and an instrument and method for implanting the cage, an embodiment of the cage having a body in the shape of a circular arc and comprising a lateral concave surface, a lateral convex surface, a straight upper surface, a straight lower surface and an end wall having at least one hole, called the end hole, designed to receive a rod of an instrument for implanting the cage between the vertebrae, wherein: the end hole has an orientation that is more or less tangential to the circular arc described by the body; the extremity opposite to the end wall of the body includes a return part extending the body toward the center of the circle on which the circular arc described by the body lies.

Abstract: An artificial disc device for replacing a damaged nucleus is disclosed. In one form, the device may be inserted in components such that the device may be assembled within and retained by the natural annulus therein. In another form, the device may be inserted into the natural annulus in a collapsed or compressed state or arrangement and then be expanded within and retained by the annulus therein. In a further form, the device may be provided with a releasable connection so that the device may be connected in an insertion configuration and may be released in an operable configuration. Insertion tools and methods are also disclosed.

Abstract: An endoprosthesis component is formed from a ceramic material and in which the ceramic material is partially coated with a titanium alloy. An uncoated surface portion of the endoprosthesis component is designed to interact as slide surface with another endoprosthesis component. A coated surface portion of the endoprosthesis component is designed to establish a connection to a bone. The part of the ceramic material forming an interface to the coating has a roughness Ra of between 2.5 ?M and 7 ?M, creating a firm connection between the coating and the ceramic material. The invention further relates to a method for producing such an endoprosthesis component. To achieve the desired roughness of the surface, the ceramic component is presintered at a temperature of between 880° C. and 980° C. and is then treated with a blasting material.

Abstract: The invention consists of disc replacement implant for the lumbar spine designed for insertion into the disc space via a posterior approach. The implant can be stabilized in the disc space by connection to the vertebra or can be connected to dynamic spinal stabilization device consisting of interconnected bullets nested in a spring nested in a woven sleeve. By controlling the limits of elongation and compression the device prevents movement beyond normal physiological limits. In the midrange of movement flexibility is allowed. A method for using the dynamic spinal stabilization device is also provided.

Abstract: An intervertebral expandable spacer having a pair of co-axial annuluses locked together by an engagement member having i) a set screw and ii) a pressure plate having an outer face contacting the set screw and an inner face having teeth adapted to mate with the ratchet notches of the second member.

Abstract: Disclosed are methods for implant installation and assembly between adjacent vertebral bodies of a patient. The implant has a support body and a rotatable insert therein and the support body is curved for installation between adjacent vertebral bodies transforaminally. An installation instrument is also disclosed for removable attachment to implant and engagement with the rotatable insert to selectively permit rotation between the insert and the support body. The installation instrument extends along a longitudinal tool axis and when the installation instrument is in a first position the insert is rotationally fixed with respect to the support body and when the installation instrument is in a second position the support body may rotate with respect to the insert. Methods of installing multiple implants are also disclosed.

Abstract: A shoulder prosthesis includes a vault-filling component defining a bearing-facing surface and having a first coupling component, the vault-filling component including (i) a vault-filling first portion defining a first part of the bearing-facing surface, and (ii) a projecting second portion projecting from the vault-filling first portion so as to define a second part of the bearing-facing surface. The vault-filling first portion and the projecting second portion define a bone space therebetween. The shoulder prosthesis further includes a bearing component defining a bearing surface and having a second coupling component configured to cooperate with the first coupling component to couple the bearing component to the vault-filling component. At least one bone attachment member positioned in the bone space. The projecting second portion of the vault-filling component further defines a scapula-facing surface.

Abstract: One embodiment of the present invention relates to a reverse shoulder assembly. Another embodiment of the present invention relates to a reverse shoulder assembly method of use. In one example, a reverse shoulder assembly of the present invention may be provided such that the reverse shoulder assembly alters the abduction force created by a patient's deltoid to a forward flexion force. In one example, a reverse shoulder assembly of the present invention may be provided such that the reverse shoulder assembly alters the abduction force created by a patient's deltoid to an external rotation force. In one example, a reverse shoulder assembly of the present invention may be provided such that the reverse shoulder assembly alters the abduction force created by a patient's deltoid to an external rotation force and a forward flexion force.

Abstract: Modular bone implants, modes of assembly, and their method of use are presented.

Abstract: In a method for securing and disabling an electronic device, the electronic device automatically executes a basic input/output system (BIOS) component of a security and tracking service during boot up. The BIOS component automatically determines whether an application component of the security and tracking service has requested disabling of the electronic device. In response to a determination that the application component has requested disabling of the electronic device, the BIOS component automatically displays system information and unlock key. The BIOS component also automatically prompts a user of the electronic device to enter an activation password to re-enable the electronic device. Other embodiments are described and claimed.

Abstract: An electronic device, prior to entering a distribution channel, is equipped with a loss prevention client which permits limited use of the device until correct authentication is provided by a legitimate purchaser. By permitting limited use before authentication, the device remains both useful to a legitimate purchaser and valuable to a thief. While allowing operation in the possession of a thief, options can be provided to permit tracking of the device or to allow proper purchase of the device.

Abstract: The present invention relates to a composition for treating keratin fibers, and in particular human keratin fibers such as the hair, comprising, in a cosmetically acceptable medium, one or more alkanolamines, one or more basic amino acids and one or more additional alkaline agents chosen from aqueous ammonia; ammonium salts of acids whose pKa at 25° C. is greater than 4; alkali metal or alkaline-earth metal hydroxides, carbonates, carbamates and hydrogen carbonates. The present invention also relates to processes for bleaching and/or dyeing keratin fibers, and also to multi-compartment devices or ‘kits’ for performing these processes.

Abstract: Process for preparing a cocrystal of an active substance and a cocrystal former, the process involving precipitating the active substance and the cocrystal former together from solution or suspension, in the presence of a supercritical or near-critical fluid, in particular using a GAS, SAS, SEDS or SAS-EM process. The invention also provides a cocrystal prepared using such a process, and its use as a seed crystal in a subsequent process for precipitating a cocrystal of an active substance and a cocrystal former.