Patents Issued in August 23, 2012
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Publication number: 20120214932Abstract: Disclosed is a polyphenylene ether-based resin composition that includes (A) a base resin including (A-1) polyphenylene ether-based resin and (A-2) polyamide resin, (B) carbon nanotubes, (C) a styrene-based copolymer, and (D) an olefin-based copolymer.Type: ApplicationFiled: April 30, 2012Publication date: August 23, 2012Applicant: CHEIL INDUSTRIES INC.Inventors: Jin-Young HUH, Doo-Han HA
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Publication number: 20120214933Abstract: The present invention relates to a tyre, the tread of which comprises an elastomer composition comprising: from 10 to 60 phr of a polybutadiene (BR) elastomer; from 10 to 60 phr of a saturated thermoplastic styrene (TPS) elastomer; a reinforcing filler. The combined use of BR and saturated TPS elastomers makes it possible to increase the stiffness and thus to improve the handling performance of the tyres, without adversely affecting the hysteresis and therefore the rolling resistance of these tyres.Type: ApplicationFiled: June 28, 2010Publication date: August 23, 2012Applicants: MICHELIN RECHERCHE ET TECHNIQUE S.A., SOCIETE DE TECHNOLOGIE MICHELINInventors: Béatrice Lopez, Didier Vasseur
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Publication number: 20120214934Abstract: This invention relates to improved adhesion compositions and textile materials and articles treated therewith. The improved adhesion composition comprises a non-crosslinked resorcinol-formaldehyde and/or resorcinol-furfural condensate (or a phenol-formaldehyde condensate that is soluble in water), a rubber latex, and an aldehyde component such as 2-furfuraldehyde. The composition may be applied to textile substrates and used for improving the adhesion between the treated textile substrates and rubber materials. End-use articles that contain the treated textile-rubber composite include, without limitation, automobile tires, belts, and hoses as well as printing blankets.Type: ApplicationFiled: February 17, 2011Publication date: August 23, 2012Inventor: Shulong Li
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Publication number: 20120214935Abstract: Disclosed is a method for producing an oxygen scavenging resin comprising: a) reacting an aromatic diacid or its diester, and an ionic diacid or its diester, with a diol and a metal compound to produce an ionic copolyester, b) cooling, cutting and drying the ionic copolyester into solid pellets, and c) mixing the dried ionic copolyester with a dried oxidizable polymer, provided that the oxidizable polymer is not a partially aromatic polyamide. Also disclosed is i) a composition made by the above method wherein the composition comprises an ionic copolyester, containing a metal compound, and an oxidizable polymer, provided that the oxidizable polymer is not a partially aromatic polyamide; and ii) the method of making articles from this composition.Type: ApplicationFiled: September 10, 2010Publication date: August 23, 2012Applicant: INVISTA NORTH AMERICA S.A.R.L.Inventors: Mark Ryan Roodvoets, Frank Wilhelm Embs
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Publication number: 20120214936Abstract: The present invention provides an optical pressure-sensitive adhesive sheet which has low relative dielectric constant, does not cause white turbidity by humidification, and is excellent in corrosion resistance. The present invention relates to an optical pressure-sensitive adhesive sheet, comprising: a pressure-sensitive adhesive layer in which a relative dielectric constant at a frequency of 100 kHz is 4 or less, and a moisture ratio after storage under an environment of 60° C. and 95% RH for 120 hours is 0.65 wt % or more. The optical pressure-sensitive adhesive sheet preferably has a total light transmittance of 90% or more and a haze of 3% or less.Type: ApplicationFiled: February 16, 2012Publication date: August 23, 2012Applicant: NITTO DENKO CORPORATIONInventors: Masato FUJITA, Hiroaki KISHIOKA, Hiroaki FUMOTO, Masatomo NATSUI
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Publication number: 20120214937Abstract: Methods of preparing latex-based adhesives are provided. Such methods include aging and heating of latex-films to improve performance properties with respect to tack, peel strength, and sheer strength. The latex adhesives may be used as pressure sensitive adhesives.Type: ApplicationFiled: February 23, 2011Publication date: August 23, 2012Inventors: Marc A. Dube, Lili Qie
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Publication number: 20120214938Abstract: The disclosure relates to water-dispersible polyurethane polymers as well as related polyurethane dispersion (PUD) compositions including the same, methods of making the same, methods of using the same, and articles coated with the same. The water-dispersible polyurethane polymer includes hydrophobic oligomeric polyether soft segments that include 1,2-di-substituted oxyethylene repeating units. The 1,2-di-substituted oxyethylene repeating units are derived from unsaturated fatty acid esters, such as from a distribution of epoxidized vegetable oil fatty acid esters subjected to a ring-opening polymerization process for oligomeric polyether polyol formation. The water-dispersible polyurethane polymer further includes hard segments common to other PUD compositions.Type: ApplicationFiled: February 15, 2012Publication date: August 23, 2012Applicant: EASTERN MICHIGAN UNIVERSITYInventor: Vijaykumar M. Mannari
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Publication number: 20120214939Abstract: The present disclosure provides an aqueous dispersion comprising a colorant and a polyurethane dispersant, wherein said polyurethane dispersant is comprised of a polymer having a cross-linkable moiety, wherein the cross-linkable moiety is cross-linked with a cross-linking agent.Type: ApplicationFiled: November 19, 2010Publication date: August 23, 2012Applicant: E.I. Du Pont De Nemours and CompanyInventors: Xiaoqing Li, Charles T. Berge
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Publication number: 20120214940Abstract: A thermosetting unsaturated polyester resin (UPR) composition comprising an unsaturated polyester polymer having at least two strained cycloolefinic double bonds and optional unstrained cycloolefinic double bonds, which can be cross-linked through a ring-opening metathesis polymerization (ROMP) or combination of ROMP and cationic or free radical polymerization is provided. No styrene is used in the resin composition. The thermosetting unsaturated polyester resin composition also comprises a catalyst system for the ring-opening metathesis polymerization, and in embodiments, can further comprise one or more optional unsubstituted or substituted cycloolefin monomer containing unsaturation, an optional co-catalyst selected from a cationic initiator or free radical initiator, and optional additives. The cured resin properties can be controlled through adjusting the structure and properties of the unsaturated polyester resin.Type: ApplicationFiled: February 15, 2012Publication date: August 23, 2012Inventors: Chih-Pin Hsu, Ming Yang Zhao, Steven L. Voeks
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Publication number: 20120214941Abstract: A process for preparing aqueous solutions of homo- or copolymers of acrylic acid by means of free-radical polymerization of acrylic acid and optionally water-soluble, monoethylenically unsaturated comonomers in an aqueous medium in the presence of at least one water-soluble initiator and of at least one water-soluble regulator, wherein the polymerization is conducted by means of a continuous process, and wherein, after the polymerization, low molecular weight components are at least partly removed from the resulting aqueous polymer solution. For the polymerization, preference is given to using microstructured mixers and reactors. Preference is given to using at least one reactor and/or mixer with microstructures for the process.Type: ApplicationFiled: November 2, 2010Publication date: August 23, 2012Applicant: BASF SEInventors: Matthias Kleiner, Wolfgang Loth, Markus Brym, Elke Gütlich-Hauk, Bolette Urtel, Ruth Wirschem, Jürgen Detering
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Publication number: 20120214942Abstract: A powder molded product produced through molding of a slurry containing a powdery molding raw material, a dispersion medium for dispersing the molding raw material, a dispersant for uniformly dispersing the molding raw material in the dispersion medium, a binder precursor for producing an organic binder through a chemical reaction, a reaction promoter for promoting the chemical reaction, and a pseudo-plasticity-imparting agent for imparting pseudo-plasticity to the slurry. The method for producing a powder molded product of the present invention includes a slurry preparation step; a molding step of molding the prepared slurry into a primary molded product having a specific shape; and a drying-solidification step of solidifying the slurry by promoting the aforementioned chemical reaction in the primary molded product, and removing, through evaporation, the dispersion medium from the primary molded product.Type: ApplicationFiled: February 9, 2012Publication date: August 23, 2012Applicant: NGK Insulators, Ltd.Inventors: Toshiki HIRAIWA, Hidemi Nakagawa
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Publication number: 20120214943Abstract: Disclosed is a process for producing a thermoplastic elastomer composition having a matrix phase comprising a polyamide and an ethylene/vinyl alcohol copolymer and a disperse phase comprising a rubber composition, by which gelation by a reaction between a polyamide and an ethylene/vinyl alcohol copolymer can be inhibited and the dispersion of the rubber composition can be good. In the process, the polyamide resin and the rubber composition are melt-blended to the extent necessary for the rubber composition to form a disperse phase, and then the ethylene/vinyl alcohol copolymer is added and further melt-blended together.Type: ApplicationFiled: May 23, 2011Publication date: August 23, 2012Applicant: The Yokohama Rubber Co., Ltd.Inventors: Shun Sato, Koichi Kawaguchi
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Publication number: 20120214944Abstract: Polymeric compositions and methods of forming the same are described herein. The methods generally include contacting a polyolefin and a lactide in the presence of a catalyst within an extruder under conditions sufficient to polymerize the lactide and form a polymeric composition including polyolefin and polylactic acid.Type: ApplicationFiled: February 18, 2011Publication date: August 23, 2012Applicant: Fina Technology, Inc.Inventors: FENGKUI LI, John Ashbaugh
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Publication number: 20120214945Abstract: A cross-linkable nitrile rubber composition obtained by mixing a master batch (B) which contains a nitrile copolymer rubber (b1) having an iodine value of 120 or less and an aromatic polyvalent amine cross-linking agent (b2) into a carboxyl group-containing nitrile copolymer rubber (A) having an iodine value of 120 or less and a cross-linked product obtained by cross-linking the same are provided.Type: ApplicationFiled: October 19, 2010Publication date: August 23, 2012Inventor: Nobuyoshi Emori
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Publication number: 20120214946Abstract: A 10-50 g/d high strength polyethylene fiber and preparation method thereof are provided, which are in the high molecular material field. Said fiber is obtained by cross blend melt spinning method, and its strength is 10-50 g/d, its modulus is 400-2000 g/d. The material used by said cross blend melt spinning method is obtained by mixing low density polyethylene with molecular weight of 2/5-500,000 and super molecule weight polyethylene with molecular weight of 120-7000,000 in the proportion of 2-10:1. Flow modifier or diluent is not additionally added in the present invention, raw material consumption is low, extra high pressure is avoided, energy consumption and cost of production are low, technological process is simple, single line capacity is easily raised, and large scale industrial production can be realized.Type: ApplicationFiled: April 27, 2012Publication date: August 23, 2012Applicant: SHANDONG ICD HIGH PERFORMANCE FIBRES CO., LTD.Inventor: Yi REN
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Publication number: 20120214947Abstract: Heterophasic polypropylene resin comprising a propylene random copolymer matrix phase (A), and an ethylene-propylene copolymer rubber phase (B) dispersed within the matrix phase wherein the heterophasic polypropylene resin has a MFR (2.16 kg, 230° C.) of 1.0 to 100 g/10 min, determined according to ISO 1133, and a fraction soluble in p-xylene at 25° C. (XCS fraction) which is present in the resin in an amount of 28 to 50 wt %, and which has a molecular weight distribution (Mw/Mn) of 1.0 to 4.0.Type: ApplicationFiled: October 21, 2010Publication date: August 23, 2012Applicant: BOREALIS AGInventors: Katja Klimke, Petar Doshev
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Publication number: 20120214948Abstract: Methods of compounding nanoparticles with a resin, e.g., a curable resin and one or more surface modifying agents are described. The methods use wet milling technology, including both continuous and batch milling processes, and can be used to functionalize the nanoparticles and disperse the functionalized nanoparticles into the resin system in a single process. Methods of compounding curable resin systems containing reactive diluents are also disclosed.Type: ApplicationFiled: October 21, 2010Publication date: August 23, 2012Inventors: Peter D. Condo, Jung-Sheng Wu, Chad A. Haraldson, William J. Schultz, Emily S. Goenner, James E. Thorson, Wendy L. Thompson
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Publication number: 20120214949Abstract: A polymer having a repeating unit represented by formula (1). [R1 represents a hydrogen atom, a halogeno group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group, a trialkylsilyl group, or a trialkylgermyl group, each R2 is independently represented by the following formula (2), m is an integer of from 1 to 5, and when a plurality of R2s are present, the R2s may be the same as or different from each other.] [Each X is independently a monovalent group, and the plurality of Xs may be the same as or different from each other, at least one X is a monovalent group containing a halogen atom, and p is an integer of from 0 to 10.Type: ApplicationFiled: August 12, 2010Publication date: August 23, 2012Applicants: SUMITOMO CHEMICAL COMPANY, LIMITED, NIIGATA UNIVERSITYInventors: Toshiki Aoki, Masahiro Teraguchi, Takashi Sato, Taketsugu Yamamoto
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Publication number: 20120214950Abstract: Methods for forming rosin-derived cationic compounds are provided. The method can include attaching a cationic group to a conjugated diene on a hydrophenathrene-based ring of a resin acid (e.g., levopimaric acid, abietic acid, dehydroabietic acid, or a mixture thereof) to form a rosin-derived cationic compound. Attaching the cationic group to the conjugated diene on the hydrophenathrene-based ring of the resin acid can be achieved via a Diels-Alder reaction of a dienophile with the hydrophenathrene-based ring of the resin acid. Rosin-derived cationic compounds are also provided. The rosin-derived cationic compound can include a cationic group attached to a conjugated diene on a hydrophenathrene-based ring of a resin acid, wherein the rosin-derived cationic compound further comprises a carboxylic acid group.Type: ApplicationFiled: February 15, 2012Publication date: August 23, 2012Applicant: UNIVERSITY OF SOUTH CAROLINAInventors: Chuanbing Tang, Jifu Wang, Alan W. Decho, Yung Pin Chen
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Publication number: 20120214951Abstract: Methods of producing polyphosphazene microspheres comprising admixing aqueous solutions of a water-soluble polyphosphazene and an organic amine, or salt thereof, are disclosed.Type: ApplicationFiled: April 30, 2012Publication date: August 23, 2012Inventors: Alexander K. Andrianov, Bryan E. Roberts
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Publication number: 20120214952Abstract: Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.Type: ApplicationFiled: May 3, 2012Publication date: August 23, 2012Applicant: Nektar TherapeuticsInventors: Antoni Kozlowski, Jon McKannan, Samuel P. McManus
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Publication number: 20120214953Abstract: Phosphorus-containing compounds useful for flame retardant epoxy resins are disclosed. The flame retardant epoxy resins may be used to make electrical laminates. This invention is particularly useful in end use applications in which a low bromine or low halogen content is required or desired.Type: ApplicationFiled: May 3, 2012Publication date: August 23, 2012Applicant: Dow Global Technologies LLCInventor: Joseph Gan
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Publication number: 20120214954Abstract: A polymer having a density of from about 0.94 g/cm3 to about 0.96 g/cm3 and a primary structure parameter 2 (PSP2 value) of greater than about 8.5, wherein an article formed from the polymer has an environmental stress crack resistance of equal to or greater than about 1000 hours when measured in accordance with ASTM D 1693 condition A. A polymer having at least one lower molecular weight component and at least one higher molecular weight component and having a PSP2 value of equal to or greater than about 8.5, wherein an article formed from the polymer has an environmental stress crack resistance of greater than about 1000 hours when measured in accordance with ASTM D 1693 condition A.Type: ApplicationFiled: February 21, 2011Publication date: August 23, 2012Applicant: CHEVRON PHILLIPS CHEMICAL COMPANY LPInventors: Richard M. BUCK, Albert P. MASINO, Qing YANG, Paul J. DESLAURIERS, Steven J. SECORA, Elizabeth M. LANIER, Guylaine ST. JEAN, Jon D. RATZLAFF, Christopher E. WITTNER
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Publication number: 20120214955Abstract: This invention relates to a supported nonmetallocene catalyst and preparation thereof. The supported nonmetallocene catalyst can be produced with a simple and feasible process and is characterized by an easily controllable polymerization activity. This invention further relates to use of the supported nonmetallocene catalyst in olefin homopolymerization/copolymerization, which is characterized by a lowered assumption of the co-catalyst as compared with the prior art.Type: ApplicationFiled: October 13, 2010Publication date: August 23, 2012Inventors: Hongping Ren, Chuanfeng Li, Xiaoli Yao, Feng Guo, Zhonglin Ma, Haibin Chen, Kaixiu Wang, Jingwei Liu, Yaming Wang
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Publication number: 20120214956Abstract: The present invention relates to a process of producing an ethylene polymer composition in multiple stages, of which the first stage is preferably a slurry polymerization stage, in the presence of a catalyst system, comprising: a) a solid catalyst precursor, comprising a transition metal selected from titanium and vanadium; magnesium; a halide, optionally an electron donor; and a solid particulate material comprising an inorganic oxide, and wherein the median particle diameter, D50, of the solid catalyst precursor, based upon the total volume of solid catalyst precursor, is from 1 to 13 micrometers; and b) an organoaluminium compound.Type: ApplicationFiled: May 3, 2012Publication date: August 23, 2012Applicant: Dow Global Technologies LLCInventors: Patrick J.C. Schouterden, Ruddy Nicasy, Sarat Munjal, Burkhard E. Wagner, Robert J. Jorgensen
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Publication number: 20120214957Abstract: This invention relates to a supported nonmetallocene catalyst and preparation thereof. The supported nonmetallocene catalyst can be produced with a simple and feasible process and is characterized by an easily controllable polymerization activity. This invention further relates to use of the supported nonmetallocene catalyst in olefin homopolymerization/copolymerization, which is characterized by a lowered assumption of the co-catalyst as compared with the prior art.Type: ApplicationFiled: October 13, 2010Publication date: August 23, 2012Inventors: Chuanfeng Li, Hongping Ren, Xiaoli Yao, Zhonglln Ma, Feng Guo, Kaixiu Wang, Jingwei Liu, Yaming Wang, Lijuan Yang
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Publication number: 20120214958Abstract: An epoxy oxazolidone including the reaction product of (a) a divinylarene dioxide, and (b) an excess of a polyisocyanate to provide an epoxy oxazolidone composition; wherein the composition has an oxazolidone selectivity of greater than 40% relative to the total of the carbonyl compounds; a process for making the epoxy oxazolidone; and a curable epoxy resin composition including (i) the epoxy oxazolidone derived from a divinylarene dioxide such as divinylbenzene dioxide (DVBDO) and a polyisocyanate, (ii) at least one curing agent; and/or (iii) a catalyst. The cured product made from the above epoxy resin composition is thermally stable and offers improved properties such as a lower viscosity and a high heat resistance compared to known cured products prepared from known epoxy resins.Type: ApplicationFiled: October 15, 2010Publication date: August 23, 2012Inventor: Maurice J. Marks
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ORGANOTIN COMPOUNDS, PREPARATION METHOD THEREOF, AND PREPARATION OF POLYLACTIDE RESIN USING THE SAME
Publication number: 20120214959Abstract: The present invention relates to an organotin compound represented by R1O—Sn—OR2 (where R1 and R2 are independently a primary, secondary, or tertiary alkyl group having 5 to 30 carbon atoms), a preparation method thereof, and a preparation method for polylactide using the organotin compound. The organotin compound of the present invention is easy to prepare and is used to prepare a polylactide resin having a high molecular weight at a high yield without using a separate initiator.Type: ApplicationFiled: August 31, 2010Publication date: August 23, 2012Applicant: LG Chem, LTDInventors: In-Su Lee, Sung-Cheol Yoon, Seung-Young Park, Seong-Woo Kim, Young-kyu Do, Kang-Mun Lee -
Publication number: 20120214960Abstract: The present invention relates to a polyester resin prepared by adding an anti-hydrolysis agent to a reactant comprising an acid selected from an alkylester of aromatic dibasic acid or a mixture of an alkylester of aromatic dibasic acid and an alkylester of aliphatic dibasic acid, an aromatic diol and an aliphatic diol; and a toner produced by using the same as a binder resin.Type: ApplicationFiled: October 22, 2010Publication date: August 23, 2012Inventors: Ui Gab Joung, Hyung Jin Roh, Yun Ju Chang, Sung Hwan Cho, Byung Ho Lim
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Publication number: 20120214961Abstract: A dimethyl terephthalate residual composition including a. dimethyl terepthalate derived from a terephthalic-containing polyester homopolymer, terephthalic-containing polyester copolymer, or a combination thereof and b. from more than 0 to less than 5.1 wt. % of a residual component selected from dimethyl isophthalate, cyclohexane dimethanol, diethylene glycol, triethylene glycol, or a combination thereof.Type: ApplicationFiled: February 22, 2011Publication date: August 23, 2012Applicant: SABIC INNOVATIVE PLASTICS IP B.V.Inventors: Philip Wesley BELL, Dhaval Shah
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Publication number: 20120214962Abstract: Implementations and techniques for preparing and using monomers, oligomeric complexes, and coordination polymers are generally disclosed.Type: ApplicationFiled: February 18, 2011Publication date: August 23, 2012Inventor: Yongshu Xie
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Publication number: 20120214963Abstract: Aspart modified proinsulin sequences that have a modified C-peptide amino acid and/or nucleic acid modification for producing aspart insulin analogs are provided. Highly efficient processes for preparing the aspart insulin analogs and improved preparations containing the aspart insulin analogs prepared according to the methods described herein are also provided.Type: ApplicationFiled: February 23, 2011Publication date: August 23, 2012Applicant: Elona BiotechnologiesInventors: Ronald E. Zimmerman, David John Stokell, Michael Patrick Akers
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Publication number: 20120214964Abstract: Disclosed herein are novel and improved preparations and methods for manufacturing substantially liquid preparations of recombinant human insulin API. The purified recombinant human insulin Active Pharmaceutical Ingredient (API) preparations are substantially free of by-products associated with the lyophilization and/or crystallization. The methods for manufacturing the substantially liquid recombinant human insulin API preparations are provided with optional steps for subjecting the recombinant insulin preparation to lyophilization and/or crystallization. Enhanced yield of recombinant insulin of greater purity are thereby provided according to the present invention. Highly purified formulations of recombinant human insulin of the API insulin preparations disclosed herein are also provided. Stably transformed E. coli cell banks (WCB) capable of expressing the recombinant human insulin are also provided.Type: ApplicationFiled: February 23, 2011Publication date: August 23, 2012Applicant: Elona BiotechnologiesInventors: Ronald E. Zimmerman, David John Stokell, Michael Patrick Akers
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Publication number: 20120214965Abstract: Glargine proinsulin sconstructs that have a modified C-peptide amino acid and/or nucleic acid sequence for producing glargine insulin analogs are provided. Highly efficient processes for preparing the glargine insulin analogs and improved preparations containing the glargine insulin analogs prepared according to the methods described herein are also provided.Type: ApplicationFiled: February 23, 2011Publication date: August 23, 2012Applicant: Elona BiotechnologiesInventors: Ronald E. Zimmerman, David John Stokell, Michael Patrick Akers
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Publication number: 20120214966Abstract: A process is disclosed for separating biomolecules from an aqueous solution containing the biomolecules and impurities, having different affinities and/or interactions with a solid support. The solution is passed over a fixed bed of chromatographic resin containing at least three zones, with flow of liquid being arranged between adjacent zones and between a last and first zone. Each of several sequences includes at least an adsorption stage, a rinsing stage, or a desorption stage, with each subsequent sequence being carried out by a downstream displacement of fronts in the zones by approximately the same increment before the periodical displacement of the introduction and withdrawal points.Type: ApplicationFiled: April 17, 2012Publication date: August 23, 2012Applicant: GROUPE NOVASEPInventors: Marc-André Theoleyre, Stanislas Baudouin, Annick Merrien, Eric Valery, Olivier Ludemann-Hombourger, David Laurent, Margit Holzer
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Publication number: 20120214967Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.Type: ApplicationFiled: September 21, 2011Publication date: August 23, 2012Applicant: THERAVANCE, INC.Inventor: Daniel D. Long
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Publication number: 20120214968Abstract: The present invention relates to novel phalloidin derivatives and their fluorescent dye conjugates. These new compounds may be used in studies of actin dynamics in living systems. The present invention also relates to methods for preparing such compounds. The synthesis routes combine solid-phase and solution phase peptide synthesis, and has great advantage for efficient preparation of a diverse library of the phalloidin derivatives, especially for the synthesis of phalloidin.Type: ApplicationFiled: February 10, 2012Publication date: August 23, 2012Inventors: Baosheng Liu, Jianheng Zhang
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Publication number: 20120214969Abstract: The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use in PET imaging. In particular embodiments, the labeled molecules may be peptides or proteins, although other types of molecules may be labeled and utilized. Preferably, the F-18 is attached to a targeting molecule by formation of a metal complex and binding of the F-18-metal complex to a chelating moiety. In other embodiments, the metal may first be attached to the chelating group and subsequently the F-18 bound to the metal. More preferably, the F-18 label moiety may be attached to a targetable conjugate that is used for pretargeting in combination with a bispecific or multispecific antibody. The F-18-metal labeled molecules are stable in human serum at 37° C.Type: ApplicationFiled: February 29, 2012Publication date: August 23, 2012Applicant: IMMUNOMEDICS, INC.Inventors: William J. McBride, David M. Goldenberg
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Publication number: 20120214970Abstract: The present invention provides a mutant streptavidin subunit which comprises one or more amino acid substitutions compared to a wildtype streptavidin subunit at any one of residue positions equivalent to positions (50, 51, 52, 53) and (54) of SEQ ID NO. 2 and wherein amino acid residues at positions equivalent to positions (23, 27, 43, 45, 49, 79, 88, 90, 92, 108, 110) and (128) of SEQ ID NO. 2, in said mutant streptavidin subunit, are wildtype, wherein (i) when said mutant streptavidin subunit unit is comprised in streptavidin, said streptavidin has a lower off rate for biotin or for a biotin conjugate than wildtype streptavidin or (ii) when said mutant streptavidin subunit is in monomelic form said mutant monomelic streptavidin has a lower off rate for biotin or a biotin conjugate than monomelic streptavidin. The invention also encompasses nucleic acid molecules comprising a nucleotide sequence encoding the mutant streptavidin subunit and vectors and cells comprising the nucleic acid.Type: ApplicationFiled: October 28, 2010Publication date: August 23, 2012Inventor: Mark Howarth
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Publication number: 20120214971Abstract: The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.Type: ApplicationFiled: November 30, 2011Publication date: August 23, 2012Inventors: Sek Chung Fung, Matthew Moyle, Mason Lu, Changning Yan, Sanjaya Singh, Dan Huang
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Publication number: 20120214972Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.Type: ApplicationFiled: October 20, 2010Publication date: August 23, 2012Applicant: THE WASHINGTON UNIVERSITYInventors: Kenneth Murphy, Norihiko Watanabe, Theresa Murphy, Jianfei Yang
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Publication number: 20120214973Abstract: A method of immobilising a target molecule on a substrate, which comprises exposing the target molecule to the substrate in the presence of a metal complex, wherein the target molecule is an unmodified target molecule, and wherein the metal complex is selected to provide a stable binding interaction between the target molecule and the substrate.Type: ApplicationFiled: March 2, 2012Publication date: August 23, 2012Applicant: BIO-LAYER PTY LIMITEDInventors: Benjamin Ward MUIR, Michaael C. BARDEN, Dennis Brian RYLATT, N. Joe MAEJI, Carmel Judith HILLYARD, Alain-Dominique Jean-Pierre GORSE, Raisa Leonidovna MONTEIRO
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Publication number: 20120214974Abstract: A spin column device, which contains a rigid porous filter that retains its shape during centrifugation, chromatography methods using the device to isolate a desired substance, e.g., a biological molecule, from other substances in a mixture, and kits containing the device with one or more reagents for use in the method.Type: ApplicationFiled: May 2, 2012Publication date: August 23, 2012Applicant: BIOVENTURES, INC.Inventor: Elliott P. Dawson
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Publication number: 20120214975Abstract: The present invention relates to cells for producing a molecule lacking fucose, having a reduced amount of fucose, or having other atypical sugars on its glycomoieties. It also relates to methods for producing a molecule lacking fucose, having a reduced amount of fucose, or having other atypical sugars on its glycomoieties using said cells and to molecules obtainable by said methods. The present invention further relates to molecules having an artificial glycosylation pattern.Type: ApplicationFiled: September 21, 2010Publication date: August 23, 2012Inventors: Volker Sandig, Hans Henning Von Horsten, Christiane Ogorek
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Publication number: 20120214976Abstract: The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations.Type: ApplicationFiled: August 22, 2011Publication date: August 23, 2012Applicant: Cytos Biotechnology AGInventors: Susanne Richter, Simon Topell
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Publication number: 20120214977Abstract: The invention relates to a scraped surface heat exchanger (100) comprising a heat exchanging wall (20) having an cylindrical inner surface (21) with a radius (R+.delta.), a shaft (10) being rotatable mounted inside of and concentrically to the inner surface (21) of the heat exchanging wall (20) and having at least one gap portion (10A) with an outer surface (11) and a radius (R), and at least one scraping member (40) supported by the shaft (10) and extending to the inner surface (21) of the heat exchanger wall (20), characterised in that the at least one or the gap portions (10A) with an outer surface (11) and a radius (R) extend over at least 60% of the circumference of the shaft (10).Type: ApplicationFiled: March 6, 2012Publication date: August 23, 2012Applicant: INVENSYS APV A/SInventors: Knud THORSEN, Preben Koeningsfeldt, Ole Poulsen
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Publication number: 20120214978Abstract: Methods and reagents are disclosed for reducing an amount of non-covalently bound polysaccharide on a support. The method comprises contacting a support comprising both covalently bound polysaccharide and non-covalently bound polysaccharide with an aqueous solution comprising an amount of a chaotropic agent effective to remove non-covalently bound polysaccharide from the support.Type: ApplicationFiled: February 17, 2011Publication date: August 23, 2012Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.Inventors: Bhalchandra Lele, Pratap Singh, Asoke Chatterjee
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Publication number: 20120214979Abstract: The present invention relates to a process for the production of microfibrillated cellulose wherein the process comprises the steps of, providing a slurry comprising fibers, adding the slurry to an extruder, treating the slurry in the extruder so that the fibers are defibrillated and microfibrillated cellulose is formed. The invention further relates to a microfibrillated cellulose produced.Type: ApplicationFiled: October 26, 2010Publication date: August 23, 2012Inventors: Isto Heiskanen, Ali Harlin, Kaj Backfolk, Risto Laitinen
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Publication number: 20120214980Abstract: Provided is a method for efficiently preparing alkali cellulose having a uniform alkali distribution. More specifically, provided are a methods for preparing alkali cellulose comprising a contact filtration step of bringing a pulp into contact with an alkali metal hydroxide solution on a moving filtration plane for vacuum filtration to collect a contact product remaining on the filtration plane, and a draining step of draining the contact product; and a method of preparing cellulose ether by using the alkali cellulose. Also provided is an apparatus for preparing alkali cellulose comprising a continuous horizontal vacuum filter type contactor.Type: ApplicationFiled: February 16, 2012Publication date: August 23, 2012Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Mitsuo Narita
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Publication number: 20120214981Abstract: A degree of polymerization of cellulose ether is accurately controlled, and quality and a manufacturing process of the cellulose ether are stabilized. There is provided a method for producing depolymerized alkali cellulose having a degree of polymerization controlled, comprising at least a step of depolymerizing, in the presence of an oxygen-containing gas flow, alkali cellulose obtained by bringing a pulp into contact with an alkali solution, while measuring feeding and discharging amounts of oxygen in the oxygen-containing gas flow. There is also provided a method for producing cellulose ether, comprising at least a step of adding an etherifying agent to the depolymerized alkali cellulose having a degree of polymerization controlled.Type: ApplicationFiled: February 16, 2012Publication date: August 23, 2012Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Mitsuo NARITA