Abstract: A method of making a polysiloxane containing polymer is described. The method comprises the steps of: i) Preparing a polysiloxane containing polymer by the polycondensation of siloxane containing monomers and/or oligomers which comprise at least 2 condensable groups per molecule, in the presence of (a) one or more condensation catalysts and optionally one or both of (b) a diluent (a plasticizer and/or extender) and/or an end-blocking agent; and ii) Where required quenching the polymerization process. The diluent, when present, is substantially retained within the resulting diluted polysiloxane containing polymer and the process takes place at a pressure of at least 75×105 Pa (0.75 MPa).

Abstract: The invention relates to polycarbonate containing a dianhydrohexitol residue, obtainable from a polysaccharide, and a polyol residue, wherein the polycarbonate comprises between 0.2 and 5 mmol hydroxyl groups per gram polymer. The polycarbonate may be branched and comprises functional groups that can react with suitable crosslinkers. The polycarbonate can be used in for example coating compositions.

Abstract: Disclosed is a polyamide composition including at least one semi-aromatic copolyamide, said semi-aromatic copolyamide consisting essentially of 40 to 60 mole percent repeat units of the formula —C(O)(CH2)4C(O)NHCH2ArCH2NH—??(I) and 40 to 60 mole percent repeat units of the formula —C(O)(CH2)4C(O)NH(CH2)6NH—??(II) wherein Ar is a meta-substituted benzene ring. Also disclosed are molded articles including the polyamide composition.

Abstract: HVAC and building and construction components are molded from novel compositions that meet the flame spread and smoke index, as well as the molding, safety, strength, and aesthetic requirements for this use. These compounds are based on a polyester resin and more specifically can be an polypropylene glycol dicyclopentadiene copolymerized with maleic anhydride, a low profile additive and hydroxy ethyl methacrylate monomer with additional additives including an appropriate catalyst package, a mold release agent, a thickening agent, a loading of aluminum hydroxide which is from about 40 to 65% by weight, and having a loading of glass fibers of from about 10 to about 25%.

Abstract: The present invention relates to a resin composition comprising (a) an unsaturated polyester resin having a molecular weight Mn of at least 750 Dalton and at most 5000 Dalton and (b) a reactive diluent, wherein the unsaturated polyester resin comprises C5-C10 unsaturated diacid building blocks and isosorbide building blocks. Preferably, at least part of the isosorbide is derived from a non-fossil source. Preferably, itaconic acid or anhydride is used as the C5 unsaturated dicarboxylic acid.

Abstract: A resin composition including the following components (A) to (C): (A) polyarylene sulfide resin: 20 wt %<component (A)?60 wt %; (B) hexagonal boron nitride: 8 wt %?component (B)?55 wt %; and (C) flat glass fiber: 15 wt % ?component (C)?55 wt % wherein the amount ratio of each component is a weight percentage relative to the total amount of the components (A) to (C).

Abstract: A phosphorous flame retardant primarily includes hexachlorotriphosphazene (HCP) having poly(oxyalkylene)amine substitutes. The poly(oxyalkylene)amine includes at least two end groups. The phosphorous flame retardant can further include layered silicate clay. The layered silicate clay can be intercalated and modified with the poly(oxyalkylene)amine substitutes of HCP to effectively promote thermal stability. The flame retardant, phosphazene-poly(oxyalkylene)amine adducts, can be applied to a polymer. By the cross-linking between them, the flame-retarding property of the polymer can be improved. Also provided is a method for producing the flame retardant of phosphazene-poly(oxyalkylene)amine adducts and application thereof to a polymer.

Abstract: The invention provides a oriented white polyester film, which includes at least one polyester film with a cavitation additive, wherein the cavitation additive includes poly(methyl methacrylate-co-methyl methacrylamide), a copolymer of sulfophthalate salt and nylon, polyarylate (PAR), ethylene methacrylate (EMA), ethylene methacrylate acrylic acid terpolymer (EMAAA), polyetherimide (PEI), metallocene catalyzed cyclic olefin copolymer (mCOC) or combinations thereof.

Abstract: Articles, particularly pressure pipes, having high strength as well as high stiffness and very good impact resistance even at low temperatures can be obtained by using a heterophasic polyolefin composition comprising (percent by weight) 70-90% of a random copolymer of propylene with 0.5-6% of 1-hexene, and 10-30% of a polymer of ethylene with a C3-C10 ?-olefin and optionally a diene, wherein the polymer of ethylene has an ethylene content higher than 45% and an intrinsic viscosity [?] value from 3 to 5 dl/g. A particular advantage of the present invention is that articles comprising the above heterophasic polyolefin composition show a low ductile to brittle transition temperature (DBTT).

Abstract: The present invention relates to a polycycloolefin (PCO) thermoset network assembly and a process for its preparation obtainable by polymerising a first reactive composition comprising a norbornene-type cycloolefin monomer in the presence of a Mo- or W-catalyst to obtain a PCO-Mo/W-network and polymerising a second reactive composition comprising a nor-bornene-type cycloolefin monomer in the presence of a Ru-catalyst on said PCO-Mo/W-network to obtain a PCO thermoset network assembly.

Abstract: The present invention relates to a 68Ga generator, wherein the 68Ge parent nuclide thereof is attached specifically to a support through a triethoxyphenyl group and continuously disintegrates to 68Ga, the triethoxyphenyl group being covalently bound to a support material through a linker.

Abstract: Objects of the present invention are: to provide a water-absorbent resin which exhibits excellent balances between water absorption performances; and further to provide a process by which a water-absorbent resin having excellent absorption properties can be produced even if no hydrophilic organic solvent is used, or even if its amount is extremely reduced, when carrying out the surface-crosslinking treatment; and further to provide a water-absorbent resin optimum to absorbent articles such as diapers.

Abstract: A composition comprises a fluorine-containing aromatic polymer, an epoxy compound and an initiator. Its use as film, laminate with polyimide or copper foils, copper-clad laminated board and adhesive film. The fluorine-containing aromatic polymer is preferably a fluorine-containing aryl ether polymer. The initiator is preferably a cationic initiator.

Abstract: Polymeric urethane dispersants with solubilizing polymer chains and with reactive carbon to carbon double bonds are described. The reactive double bonds facilitate molecular weight build-up of the dispersant on dispersed particles (enhancing colloidal stability) or enhance the ability of the dispersants to be crosslinked into a matrix material.

Abstract: The present invention provides a resin composition for a fiber-reinforced composite material, which has excellent fluidity and impregnation into a fiber base material and which produces a cured product having excellent heat resistance. A resin composition for a fiber-reinforced composite material contains, as essential components, a poly(glycidyloxyaryl) compound (A), a polymerizable monomer (B) which is an unsaturated carboxylic acid or an anhydride thereof and has a molecular weight of 160 or less, an aromatic vinyl compound or a (meth)acrylate (C), and a radical polymerization initiator (D), wherein an equivalent ratio [glycidyloxy group/acid group] of a glycidyloxy group in the component (A) to an acid group in the component (B) is 1/1 to 1/0.48, and a molar ratio [(B)/(C)] of the component (B) to the component (C) is in the range of 1/0.55 to 1/2.

Abstract: Methods for removing polymer skins or build-up from reactor walls in polymerization reactor systems containing a loop slurry reactor are disclosed. Such methods can employ removing some or all of the comonomer from the reactor system in combination with increasing the polymerization temperature of the loop slurry reactor.

Abstract: A polymerization initiator based on boroesters of benzopinacol for curing unsaturated polymers is disclosed. Methods of preparing the benzopinacol boroester initiator and using the initiator in polymerization reactions are additionally disclosed.

Abstract: There is provided a polymer made from a monomer having Formula I: where: R and Y are independently selected from the group consisting of H, D, alkyl, fluoroalkyl, aryl, fluoroaryl, alkoxy, aryloxy, NR?2, R?, R? is a crosslinkable group; R? is independently selected from the group consisting of H, alkyl, fluoroalkyl, aryl, fluoroaryl, and R?; X is a leaving group; Z is C, Si, or N; Q is (ZR?n)b; a is an integer from 0 to 5; b is an integer from 0 to 20; c is an integer from 0 to 4; q is an integer from 0 to 7; and n is an integer from 1 to 2.

Abstract: A positive resist composition including a base component (A) which exhibits increased solubility in an alkali developing solution under action of acid and an acid-generator component (B) which generates acid upon exposure, the base component (A) including a polymeric compound (A1) containing a structural unit (a0) represented by general formula (a0-1), a structural unit (a1) derived from an acrylate ester containing an acid dissociable, dissolution inhibiting group, and a structural unit (a3) derived from an acrylate ester containing a hydroxy group-containing aliphatic hydrocarbon group represented by general formula (a3-1), and the amount of the structural unit (a3) based on the combined total of all structural units constituting the polymeric compound (A1) being in the range of 1 to 30 mol %.

Abstract: Disclosed are a maleimide-a-alkylstyrene-based, heat-resistant bulk tetrapolymer and a preparation process thereof. More specifically, disclosed are a bulk tetrapolymer, comprising 5-60 wt % of an N-substituted maleimide monomer, 10-70 wt % of an a-alkylstyrene monomer, 5-50 wt % of an unsaturated nitrile monomer and 3-50 wt % of an aromatic vinyl monomer, as well as a continuous bulk polymerization process for preparing the same. The disclosed bulk tetrapolymer has a weight-average molecular weight (Mw) of 70,000-300,000 and a glass transition temperature of 150-200 DEG C., shows excellent high-temperature thermal stability and heat resistance and a remarkably low melt viscosity, and thus is excellent not only in processability, but also in productivity, processability, moldability and blendability, when it is blended with other resins. Also, the continuous bulk polymerization process is equipped with a devolatilizer and enables the bulk tetrapolymer to be produced at low cost and high efficiency.

Abstract: Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Abstract: A one step process for making a dendritic hydrocarbon polymer, e.g., dendritic polyolefin, by metathesis insertion polymerization. The process comprises polymerizing an amount of one or more cyclic olefins and one or more multi-functional (meth)acrylates in the presence of a metathesis catalyst and under conditions sufficient to produce the dendritic hydrocarbon polymer. The one or more multi-functional (meth)acrylates have a functionality of 3 or higher. The dendritic hydrocarbon polymer can be hydrogenated to produce a substantially saturated dendritic hydrocarbon polymer. The hydrogenation can take place in the same reaction vessel as the polymerization, i.e., one pot process.

Abstract: Provided is a polychloroprene latex extremely favorable in adhesive properties. The present invention relates to a method of producing a polychloroprene latex, comprising polymerizing chloroprene or a mixture of chloroprene and a monomer copolymerizable with chloroprene in an aqueous medium containing a surfactant at a concentration of lower than its critical micelle concentration (CMC) and a polymer dispersant of a metal salt of aromatic sulfonic acid formalin condensate added thereto. The polymer dispersant for use is preferably a metal salt of aromatic sulfonic acid formalin condensate. The polychloroprene latex obtained can be used as an adhesive.

Abstract: Provided is a process for making a saturated star hydrocarbon polymer. The process has the following steps: (A) hydrosilylating tetraethylene silicon with methyldichlorosilane in the presence of a hydrosilylating catalyst to form a chlorosilane dendrimer; (B) reacting the chlorosilane dendrimer with vinylmagnesium bromide in the presence of a lithium and/or organolithium initiator stepwise to build a higher generation chlorosilane dendrimer; (C) anionically polymerizing polybutadiene in the presence of a lithium and/or organolithium initiator to form living poly(butadienyl)lithium; (D) attaching the living poly(butadienyl)lithium to the higher generation dendrimer to form a star polybutadiene; and (E) hydrogenating the star polybutadiene to form the saturated star hydrocarbon polymer. There is also provided a saturated star hydrocarbon polymer made according to the above process and a polymer composition of a matrix ethylene polymer and the saturated star hydrocarbon polymer.

Abstract: The present invention provides a polyimidesilicone having a primary alcoholic hydroxyl group, which is represented by the following general formula (1): in which k and m are each a positive integer where k and m satisfy a relation of 0.01?k/(k+m)<1; and X, Y and W are as those defined in the specification.

Abstract: Methods for making polyurea polymer compositions are provided. The methods involve preparing an amine-terminated first prepolymer by reacting isocyanate compound A with a stoichiometric excess of polyamine. The first prepolymer is reacted with a stoichiometric excess of isocyanate compound B to form an isocyanate-terminated second prepolymer. The second prepolymer is reacted with a chain extender. The polymer compositions can be used in different products and are particularly suitable for making golf balls. For example, the polymer compositions can be used to make golf ball covers.

Abstract: Disclosed herein are polymer compounds and a method for preparing thereof. More specifically, provided are polymer compounds with well-connected, narrow size distribution free-volume element and a method for preparing the polymer compounds by thermal rearrangement for aromatic polyimides containing ortho-positioned functional groups in the solid state.

Abstract: A copolycarbonate-polyester, comprising units of formula wherein at least 60 percent of the total number of R1 groups are divalent aromatic organic radicals and the balance thereof are divalent aliphatic or alicyclic radicals; units of formula wherein T is a C7-20 divalent alkyl aromatic radical or a C6-20 divalent aromatic radical, and D is a divalent C6-20 aromatic radical; and units of the formula wherein R2 and R3 are each independently a halogen or a C1-6 alkyl group, R4 is a methyl or phenyl group, each c is independently 0 to 4, and T is as described above. A method of making a copolycarbonate-polyester is also disclosed.

Abstract: Nanocomposites comprising a sulfonated telechelic polycarbonate and an organically modified clay are disclosed. The polycarbonate nanocomposites have improved physical and mechanical properties.

Abstract: A polycarbonate resin which is excellent in terms of optical properties, hue, thermal stability, and mechanical properties and a transparent film formed from the resin are provided. The invention relates to a polycarbonate resin which has a glass transition temperature of 110-150° C. and a reduced viscosity, as measured at 20° C. with respect to the methylene chloride solution having a concentration of 0.6 g/dL, of 0.30-0.46, and which, when being molded, gives a film wherein the ratio of the retardation thereof measured at a wavelength of 450 nm (Re450) to the retardation thereof measured at a wavelength of 550 nm (Re550) is 0.50-0.93.

Abstract: The present invention provides a method for producing a polybenzoxazole precursor having reduced contents of residual aprotic polar solvent and residual halogen without discharging a large amount of waste water during purification. The present invention specifically relates to a method for producing a polybenzoxazole precursor, which comprises synthesizing a polybenzoxazole precursor in an aprotic polar solvent, adding and mixing water and a water-insoluble solvent with the resulting polybenzoxazole precursor solution to still stand the solution, and then separating a water layer from the solution to reduce a content of impurities remaining in the polybenzoxazole precursor.

Abstract: Disclosed is a liquid crystal photo-alignment agent including polyamic acid or a polyimide including a first structural unit derived from a photo-diamine represented by the following Chemical Formula 1, a second structural unit represented by the following Chemical Formula 2 or a polymer compound combination thereof, and a solvent. In Chemical Formulae 1 and 2, each substituent is the same as defined in the detailed description.

Abstract: A sulfonated poly(arylene ether) copolymer that has a crosslinking structure in a chain of a polymer, a sulfonated poly(arylene ether) copolymer that has a crosslinking structure in and at an end of a chain of a polymer, and a polymer electrolyte film that is formed by using them are disclosed. According to the polycondensation reaction of the sulfonated dihydroxy monomer (HO—SAr1-OH), the none sulfonated dihydroxy monomer (HO—Ar—OH), the crosslinkable dihalide monomer (X—CM-X) and the none sulfonated dihalide monomer (X—Ar—X), the poly(arylene ether) copolymer in which the sulfonic acid is included is synthesized. The formed poly(arylene ether) copolymer has the crosslinkable structure in the chain of the polymer. In addition, by carrying out the polycondensation reaction in respects to the crosslinkable monohydroxy monomer or the crosslinkable monohalide monomer, the crosslinking can be formed at the end of the polymer.

Abstract: A polyether polymer containing a defined polymerization unit (—R1—O—R2—O—), R1 and R2 being derived from monomers (A) and (B), respectively; and a process for producing the polyether polymer comprising the step of copolymerizing the monomer (A) with the monomer (B) in the presence of a metal salt, wherein the monomer (A) is (A1) a non-conjugated mono-cyclic diene compound containing a cyclic skeleton, or (A2) a non-conjugated cyclic diene compound containing a mutual linking of plurality of a mono-cyclic structure having a cyclic skeleton, and the monomer (B) is an aliphatic diol, an alicyclic diol or a divalent phenol.

Abstract: The present invention is directed to polypeptides (e.g., fragments) derived from P-glycoprotein and caveolin-1 which are capable of inhibiting the interaction between these two proteins. Inhibition of this interaction leads to increase of efflux of compounds that are transported by P-gp. The invention further includes methods of treating patients having diseases that benefit from increased P-gp-mediated efflux. Such diseases include neoplasms such as cancer and neurological diseases such as neurodegenerative diseases.

Abstract: A melanocortin receptor agonist cyclic peptide of the formula where R, x and y are as defined in the specification, compositions and formulations including the peptide of the foregoing formula, and methods of preventing, ameliorating or treating melanocortin receptor-mediated diseases, indications, conditions and syndromes, including sexual dysfunction such as male erectile dysfunction and female sexual dysfunction.

Abstract: The present invention relates to the use of an antisecretory protein, derivative, homologue, and/or fragment thereof, having equivalent activity, and/or a pharmaceutically active salt thereof, for the manufacture of a pharmaceutical composition and/or a medical food for the treatment and/or prevention of dysfunction, e.g. abnormal function, hypo- or hyper-function of lipid rafts, receptors and/or caveolae. A dysfunction of lipid rafts, receptors and/or caveolae may be caused by or be a cause of a variety of other conditions, which are also encompassed by the present invention, such as vascular, and lung dysfunctions, and/or endocrine disorders, e.g. diabetes and related disorders. Furthermore, the invention relates to a method for the treatment and/or prevention of dysfunction of lipid rafts and/or caveolae in a mammal in need thereof.

Abstract: The invention relates to relatively short peptides (termed ?-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

Abstract: There is provided an HLA-binding peptide binding to a HLA-A type molecule, the HLA-binding peptide comprising at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 80, and consisting of not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences herein mentioned are the predicted amino acid sequences binding to a human HLA-A type molecule with the prediction program using the certain active learning method.

Abstract: A non-aqueous single pot synthesis of [18F]SFB is set forth. The [18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.

Abstract: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described.

Abstract: Provided herein are methods for using mitochondria-targeted electron scavengers as anti-inflammatory agents. The mitochondria-targeted electron scavenger comprises a free radical-scavenging group covalently linked to a mitochondria-targeting group derived from a hemigramicidin moiety. The mitochondria-targeted electron scavenger can be used to treat medical conditions associated with acute or chronic inflammation.

Abstract: Methods for introducing fluorine atom onto a polypeptide are provided. Also provided are linkers, bioconjugates, and bifunctional compound agents made using the methods, linkers, and bioconjugates. The methods comprise: (i) providing a linker comprising a thiol-reactive terminus and an aldehyde-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a polypeptide comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the aldehyde-reactive terminus of the linker with a fluorine-substituted aldehyde.

Abstract: The present invention relates to antigen-binding proteins having specificity for hepcidin, and their use for treating and diagnosing diseases associated with hepcidin.

Abstract: The present invention provides a specific binding molecule which specifically binds to a peptide having the amino acid sequence of EDGIKRIQDD and comprises a polypeptide having an immunoglobulin VL domain linked to an immunoglobulin VH domain in which the VL domain comprises Complementarity Determining Regions (CDRs) VLCDR1, VLCDR2 and VLCDR3, and in which the VH domain comprises Complementarity Determining Regions (CDRs) VHCDR1, VHCDR2, VHCDR3, each having a respective amino acid sequence as follows in which VHCDR1?is?GYSFTGYNMN VHCDR2?is?NIDPYYGGTTYNQKFKG VHCDR3?is?EVDY VLCDR1?is?RASKSVSTSTSGYSYMH VLCDR2?is?LVSNLES VLCDR3?is?QHIRELTRSEG or an amino acid sequence at least 70% identical thereto.

Abstract: The invention pertains to the field of medicine, particularly to methods for suppressing the growth of tumors, which comprise blocking the pathological pathway of human fibroblast growth factor/receptor 1 (domains II and IIIc), and for diagnosing malignant neoplasms leading to an excessive proliferation of tumor cells and to the formation of new vessels accompanied by the growth of primary tumors and metastases. This pathway also represents an independent mechanism of tumor resistance to preparations acting on other pathological pathways. Blocking the aforementioned pathway using various substances that neutralize the receptor by bonding only with domains II and IIIc thereof results in the interruption or slow-down of tumor growth. This receptor can also be used as a target for delivery of diagnostic agents being largely present in tumor cells. The invention enables developing new agents for diagnosing and treating diseases related to excessive proliferation and neovascularization.

Abstract: In some embodiments, DNA-capped nanoparticles are used to define a degree of crystalline order in assemblies thereof. In some embodiments, thermodynamically reversible and stable body-centered cubic (bcc) structures, with particles occupying <˜10% of the unit cell, are formed. Designs and pathways amenable to the crystallization of particle assemblies are identified. In some embodiments, a plasmonic crystal is provided. In some aspects, a method for controlling the properties of particle assemblages is provided. In some embodiments a catalyst is formed from nanoparticles linked by nucleic acid sequences and forming an open crystal structure with catalytically active agents attached to the crystal on its surface or in interstices.

Abstract: The present teachings provide methods, compositions, and kits for performing primer extension reactions on at least two target polynucleotides in the same reaction mixture. In some embodiments, a reverse transcription reaction is performed on a first target polynucleotide with a hot start primer comprising a self-complementary stem and a loop, and extension products form at high temperatures but extension products form less so at low temperatures since the self-complementary stem of the hot start primer prevents hybridization of the target specific region to the target. However, non-hot start primers with free target specific regions can hybridize to their corresponding targets at the low temperature and extension can happen at the low temperature.

Abstract: Provided is a technique for observing in real time the state of a disease condition in a tissue of an animal or the state of a functionally adverse condition which is a prelude to the disease condition without injuring the animal. This can be achieved by the use of a gene construct having a reporter gene integrated under the control of a hypoxia responsible promoter an ODD domain (oxygen dependent degradation domain) integrated upstream to the reporter gene.

Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence that encodes poly-glutamine repeat diseases, and methods of using these RNAi molecules.