Patents Issued in February 18, 2014
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Patent number: 8652403Abstract: An apparatus for generating superheated steam capable of reducing or eliminating microorganisms associated with an item includes a gas heater for heating a gas, a steam generator coupled to the gas heater and having a reservoir for supplying water, wherein the heater heats the gas such that when water is combined therewith, a mixture of superheated steam and gas capable of reducing or eliminating microorganisms is discharged from the apparatus. The generation of the steam-gas mixture may be done at one atmosphere of pressure and the mixing may be done prior to expelling the fluid from the apparatus. The apparatus may be configured as a hand-held device, A method of treating an item for microorganisms includes generating a superheated steam at approximately one atmosphere of pressure, directing a flow of the steam onto the item, and reducing or eliminating microorganisms using the steam.Type: GrantFiled: February 15, 2013Date of Patent: February 18, 2014Assignee: Micropyretics Heaters International, Inc.Inventors: Ganta Reddy, Jainagesh Sekhar, Ramgopal Vissa
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Patent number: 8652404Abstract: A system for ozone sterilization of waste material, includes a tank configured to receive waste material, ozonated water, and ozone gas. The system further includes a pump coupled to the tank to receive the waste material and the ozonated water from the tank and form a slurry. The pump includes a cutter assembly to reduce a particle size of the slurry through cutting. Additionally, the system includes a circulation loop coupled between the tank and the pump to receive the slurry from the pump and re-circulate the slurry to the tank until the slurry is sterilized. A method for ozone sterilization of waste material is also disclosed.Type: GrantFiled: April 9, 2013Date of Patent: February 18, 2014Assignee: Red Bag SolutionsInventors: Sanford Glazer, William D. Norton
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Patent number: 8652405Abstract: To improve throughput of biomedical waste treatment, the present inventors devised an exemplary ozone-based system including a shredder, a roll-off treatment bin with ozone injectors, an ozone source, and a controller. The controller monitors electric current drawn by the shredder as shredded waste enters the ozone-enriched treatment bin. In response to current falling below a predetermined low level, indicating that a batch of waste has been shredded and loaded into the treatment bin, the controller starts a treatment timer. The timer measures elapsed ozone treatment or exposure time. If additional waste is added to the shredder and a subsequent low-current condition is detected, the controller restarts the treatment timer. Expiration of the timer indicates that the waste in the roll-off bin is sterilized and ready for transport to landfills. The exemplary system provides continuous waste processing and promises to boost throughput by 50% over some conventional ozone-based waste-treatment systems.Type: GrantFiled: August 20, 2013Date of Patent: February 18, 2014Inventors: Peter A. Jude, Stephen E. Pellegrene, Michael J. Hofer
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Patent number: 8652406Abstract: A blood processing apparatus includes a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger is configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. In some instances, the heat exchanger is configured to cause blood flow to follow a spiral flow path.Type: GrantFiled: January 30, 2013Date of Patent: February 18, 2014Assignees: Sorin Group Italia S.r.l., Politecnico di MilanoInventors: Stefano Reggiani, Gianfranco Beniamino Fiore, Alberto Redaelli, Christian Baiotto
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Patent number: 8652407Abstract: A self-contained assay device that is capable of detecting various analyte(s), including bioanalytes, in specimens for example, from biological sources.Type: GrantFiled: November 9, 2012Date of Patent: February 18, 2014Assignee: PalmStat Diagnostics, LLCInventors: Pete Wilson, Eric Butt, Vincent Mata
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Patent number: 8652408Abstract: An apparatus for automatic execution of different treatment operations in connection with staining of tissue specimens on microscope slides, wherein the apparatus (1) comprises an assembly of vessels (4) for receiving different liquids for staining of the tissue specimens, a loading station (2) for microscope slides (28), a conveyor (5) for transfer of carriers with microscope slides from vessel to vessel in accordance with a treatment program, an unloading station (8) for treated microscope slides, and a control unit (18) for controlling the treatment operations in accordance with a data program. The apparatus comprises different levels (I, II) having units for execution of the relevant treatment operations.Type: GrantFiled: July 22, 2011Date of Patent: February 18, 2014Assignee: Dako Instrumec ASInventors: Oystein Ljungmann, Torstein Ljungmann
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Patent number: 8652409Abstract: Fluid analyte sensors include a photoelectrocatalytic element that is configured to be exposed to the fluid, if present, and to respond to photoelectrocatalysis of at least one analyte in the fluid that occurs in response to impingement of optical radiation upon the photoelectrocatalytic element. A semiconductor light emitting source is also provided that is configured to impinge the optical radiation upon the photoelectrocatalytic element. Related solid state devices and sensing methods are also described.Type: GrantFiled: November 5, 2012Date of Patent: February 18, 2014Assignee: Valencell, Inc.Inventors: Steven Francis LeBoeuf, Jesse Berkley Tucker, Michael Edward Aumer
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Patent number: 8652410Abstract: A method for controlling a selective catalytic reduction system (SCR) exploiting a set of predetermined trigger events and a set point for the NOx concentration, and an arrangement for SCR. At the occurrence of a trigger event, NOx concentration measurement downstream from the catalyst elements is started and the difference between the measured concentration and the set point is determined. If the difference is negative, the dosing of the reducing agent is decreased. If the difference is positive, the dosing of the reducing agent is increased and after system stabilization a new measurement is started. If the measured value is below the previous measured value, the same dosing is maintained. If the measured value is above the previous measured value, the dosing is decreased with an amount greater than the increase after the previous measurement.Type: GrantFiled: May 20, 2011Date of Patent: February 18, 2014Assignee: Wartsila Finland OyInventors: Daniel Nordberg, Raine Peltokoski
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Patent number: 8652411Abstract: A device for generating chlorine dioxide includes a cartridge having a chemical-holding space, in which a granular chlorite is held, a fan, and ultraviolet LED lamps disposed within a device main body, which can be separated into two or more detachable portions. The cartridge has light-transmitting properties and has a structure, which enables air to pass through the chemical-holding space and the inside of the device main body. When the fan is in operation, air is discharged from the inside of the device main body and, simultaneously therewith, air comes in from the outside of the device main body. By the action of ultraviolet rays, chlorine dioxide gas is generated from the chlorite present in the cartridge. By the operation of the fan, the gas is discharged from the inside of the device main body through air discharge ports.Type: GrantFiled: March 15, 2011Date of Patent: February 18, 2014Assignee: Taiko Pharmaceutical Co., Ltd.Inventors: Kazuhiko Taguchi, Shigeo Asada, Koichi Nakahara
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Patent number: 8652412Abstract: Methods and systems for programmed dispensation of consumable compositions are provided. A method for sterilizing a beverage container may include, but is not limited to: (a) detecting a sterilization status of a container; and (b) controlling functionality of a controllable device according to the sterilization status. A system for sterilizing a beverage container may include, but is not limited to: (a) means for detecting a sterilization status of a container; and (b) means for controlling functionality of a controllable device according to the sterilization status.Type: GrantFiled: November 4, 2010Date of Patent: February 18, 2014Assignee: The Invention Science Fund I, LLCInventors: Roderick A. Hyde, Eric C. Leuthardt, Robert W. Lord, Clarence T. Tegreene, Lowell L. Wood, Jr.
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Patent number: 8652413Abstract: A mobile body disinfection apparatus includes a carrying structure rendered mobile by means of a plurality of wheels attached thereto, a waste collection vessel, a liquid disinfectant dispensing element operated by a photoelectric cell and/or by a dispensing timer control, a filling tank, a supply line to carry the liquid disinfectant from the tank to the dispensing element, a waste tank connected to said washbasin, a drainage line and a central command and control unit suitable to manage at least the liquid disinfectant dispensing operations. The supply line comprises, in turn, at least one pump and one filter suitable to guarantee the elimination of infective elements that might be present in the water coming from the water distribution network and to guarantee a filtering of the liquid disinfectant that might have been contaminated even after filling the apparatus.Type: GrantFiled: December 30, 2008Date of Patent: February 18, 2014Assignee: V.A.R.M. S.p.A.Inventor: Gastone Vitali
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Patent number: 8652414Abstract: A device for treating containers, with a housing, a sterilization chamber formed within the housing to sterilize the containers, with a transport device which transports the containers along a pre-specified transport path (P) through the sterilization chamber, and with at least one application device which applies a liquid sterilization medium to the containers during their transport through the sterilization chamber. The application device is integrated at least partly in a wall of the sterilization chamber.Type: GrantFiled: December 15, 2011Date of Patent: February 18, 2014Assignee: Krones AGInventors: Michael Peter, Michael Weber, Sascha Hackl, Thomas Morawe
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Patent number: 8652415Abstract: An apparatus for storing and dispensing a test strip includes a container configured to store a stack of test strips. The container maintains appropriate environmental conditions, such as humidity, for storing the test strips. An engaging member is disposed in the container and is adapted to contact one test strip of the stack of test strips. An actuator actuates the engaging member to dispense the one test strip from the container. Since one test strip is dispensed at a time, the remaining test strips are not handled by the user. Accordingly, the unused test strips remain free of contaminants such as naturally occurring oils on the user's hand.Type: GrantFiled: September 13, 2010Date of Patent: February 18, 2014Assignee: Becton, Dickinson and CompanyInventor: John Lovell
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Patent number: 8652416Abstract: Disclosed are an article for assaying a target, wherein the article includes a solid surface on which a first binding member, a blocking material, and a second binding member are immobilized, a method of manufacturing the article, and a method of detecting a target using the article.Type: GrantFiled: October 15, 2009Date of Patent: February 18, 2014Assignee: Samsung Electronics Co., Ltd.Inventors: Ji Won Kim, Beom Seok Lee, In Wook Kim, Kui Hyun Kim
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Patent number: 8652417Abstract: A set of crystallization solutions includes a plurality of crystallization solutions of Crystallization Solution Set I, a plurality of crystallization solutions of Crystallization Solution Set II or a plurality of crystallization solutions of Crystallization Solution Set III.Type: GrantFiled: January 20, 2011Date of Patent: February 18, 2014Assignee: Microlytic APSInventor: Morten Sommer
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Patent number: 8652418Abstract: A pipette for a pipette system comprising a pipette and a syringe. The pipette housing has a longitudinal axis. A syringe to be handled with the pipette is insertable with its fastening portion and plunger head into the pipette housing and is removable or discardable from said pipette housing in the direction of the longitudinal axis of the pipette housing, i.e., axially. The syringe has as cylinder and a plunger with a plunger head which projects out of the end of the cylinder even when the plunger has been completely inserted into the cylinder. A pipette housing comprises an axially accessible plunger gripping device for the plunger head of the syringe. An actuating device for the plunger gripping device is mounted on the plunger displacing device and is axially displaceable with said adjusting device.Type: GrantFiled: July 1, 2011Date of Patent: February 18, 2014Assignee: Brand GmbH + Co KGInventors: Renate Rempt, Dieter Böhm, Steffen Gehrig, Ottmar Kneucker
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Patent number: 8652419Abstract: A method of manufacturing a microfluidic chip includes: irradiating, with a laser light, an area to be provided with a valley for storing a fluid on a surface of a substrate so as to form a modified region having a periodic pattern formed in a self-organizing manner in a light-collecting area of the laser light, the laser light having a pulse width for which the pulse duration is on the order of picoseconds or less; carrying out an etching treatment on the substrate in which the modified region is formed, removing at least some of the modified portion so as to provide the valley, and forming a periodic structure having a plurality of groove portions along one direction which have a surface profile based on the periodic pattern on at least a bottom surface of the valley; and forming a metal layer that covers the periodic structure of the bottom surface.Type: GrantFiled: February 4, 2013Date of Patent: February 18, 2014Assignee: Fujikura Ltd.Inventors: Satoshi Yamamoto, Tatsuo Suemasu
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Patent number: 8652420Abstract: The present invention relates to a chromatographic separation device comprising a first substrate body carrying a micro-fabricated separation channel recessed on one of its surfaces and covered by a second substrate body, both perforated with connection-holes for the supply and withdrawal of a sample and carrier liquid. The present device is characterized in that said micro-fabricated separation channel is preceded or succeeded by a flow distribution region that is filled with an array of micro-fabricated pillars, having a shape, size and positioning pattern selected such that said flow distribution region has a ratio of transversal to axial permeability of at least 2.Type: GrantFiled: May 23, 2008Date of Patent: February 18, 2014Assignee: Vrije Universiteit BrusselInventor: Gert Desmet
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Patent number: 8652421Abstract: The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.Type: GrantFiled: October 18, 2006Date of Patent: February 18, 2014Assignee: EMD Millipore CorporationInventors: Masaharu Mabuchi, Hiroko Kimura, Marc Emerick, Phillip Clark, Kurt Greenizen
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Patent number: 8652422Abstract: The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.Type: GrantFiled: April 1, 2011Date of Patent: February 18, 2014Assignee: EMD Mllipore CorporationInventors: Masaharu Mabuchi, Hiroko Kimura, Marc Emerick, Phillip Clark, Kurt Greenizen
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Patent number: 8652423Abstract: A vial and closure assembly including a vial and a closure configured to be threadably coupled to the vial. The vial has an opening end that is defined by a vial rim and at least one thread located proximate to the open end of the vial. The closure includes a top wall with a skirt wall depending from the top wall. A septum pocket is provided in the top wall and is configured to receive a septum positioned therein. A protrusion depends from the top wall, extends into the septum pocket, and is configured to engage the septum so that the septum creates an essentially vapor-tight seal with the vial rim when the closure is threadably coupled to the vial.Type: GrantFiled: July 31, 2012Date of Patent: February 18, 2014Assignee: National Scientific CompanyInventor: Leemen Loy Shick
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Patent number: 8652424Abstract: The invention relates to systems and methods for marketing and using products such as liquid materials, especially liquid reagents for use in microbiological and cellular biological laboratory settings include the use of unique color and simple numeric or alphanumeric identifiers to quickly and easily identify any product from a catalog list of products. Methods of marketing, advertising and producing such products are also disclosed. Particular embodiments include products, product packaging and product labeling. The invention also relates to collars and sleeves for containers, as well as related methods of use.Type: GrantFiled: June 9, 2008Date of Patent: February 18, 2014Assignee: Life Technologies CorporationInventors: Axel Unger, Elgin Topfer, Nicole Busch, Tom Hynek, Fredrik Aidehag, Todd Pelman, Martin Naley
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Patent number: 8652425Abstract: This invention relates to the integration of ammonium carbonate leach processes with established acid and alkaline uranium leach processes as multifunctional industrial processes for the extraction, high degree purification and conversion of processed or semi-processed uranium as U3O8, UO2, or most tetra or hexa-valent forms of uranium, and where applicable, for the recovery of uranium from uranium ores, using advanced multiple stage membrane based technologies for the separation and concentration of uranium in solution from heavy metals and lighter elements that may be present in the solution, and the selective leach and precipitation properties of an ammonium carbonate leach.Type: GrantFiled: April 19, 2011Date of Patent: February 18, 2014Inventor: Andrew Bassil
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Patent number: 8652426Abstract: The invention relates to the use of aqueous guanidinium formiate solutions, optionally combined with urea and/or ammonia and/or ammonium salts, for the selective catalytic reduction of nitrogen oxides using ammonia in exhaust gases of vehicles. The inventive guanidinium formiate solutions enable a reduction of the nitrogen oxides by approximately 90%. Furthermore, said guanidinium formiate solutions can enable an increase in the ammonia forming potential from 0.2 kg, corresponding to prior art, up to 0.4 kg ammonia per liter of guanidinium formiate, along with freezing resistance (freezing point below ?25° C.). The risk of corrosion of the inventive guanidinium formiate solutions is also significantly reduced compared to that of solutions containing ammonium formiate.Type: GrantFiled: December 20, 2007Date of Patent: February 18, 2014Assignee: AlzChem Trostberg GmbHInventors: Benedikt Hammer, Hans-Peter Krimmer, Bernd Schulz, Eberhard Jacob
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Patent number: 8652427Abstract: Method for preparing material containing amorphous iron oxide hydroxide, the method including: mixing an aqueous ferrous salt solution and hydroxide solution or solid hydroxides at the temperature of below 70° C., filtering the reaction solution, washing the filter cake, preparing suspension solution of the filter cake, blowing an oxygen-containing gas into the suspension solution to oxidize the ferrous iron, and then filtering and drying. The material after being used as desulfurization agent can be repeatedly regenerated through oxidation in an oxygen-containing gas. A desulfurization agent, and methods for preparation and repeated regeneration thereof. The desulfurization agent contains the material and organic binders, and may also include a small amount of additives. The organic binders are selected from sodium carboxymethyl cellulose, sesbania powder, and cellulose powder, and the additives are selected from sawdust, rice husk power, and bran.Type: GrantFiled: June 30, 2011Date of Patent: February 18, 2014Assignee: Beijing Sanju Environmental Protection and New Material Co., Ltd.Inventors: Zhenyi Liu, Yongsheng Yu, Ke Lin
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Patent number: 8652428Abstract: A system and method for removing contaminants from a gas stream is provided. The method can include the steps of reacting the gas stream with ozone to form solid contaminant particles and separating the solid contaminant particles from the gas stream. The solid contaminant particles can he separated from the gas stream using an adsorption material.Type: GrantFiled: October 30, 2012Date of Patent: February 18, 2014Assignee: Calpine CorporationInventors: Brian Benn, Allen Sonneville, John Farison, John Avery, Tom Bahning, Bruce Carlsen
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Patent number: 8652429Abstract: The invention provides an exhaust gas cleaning oxidation catalyst and in particular to an oxidation catalyst for cleaning the exhaust gas discharged from internal combustion engines of compression ignition type (particularly diesel engines). The invention further relates to a catalysed substrate monolith comprising an oxidizing catalyst on a substrate monolith for use in treating exhaust gas emitted from a lean-burn internal combustion engine. In particular, the invention relates to a catalysed substrate monolith comprising a first washcoat coating and a second washcoat coating, wherein the second washcoat coating is disposed in a layer above the first washcoat coating.Type: GrantFiled: October 5, 2012Date of Patent: February 18, 2014Assignees: Johnson Matthey Public Limited Company, Johnson Matthey Japan Godo KaishaInventors: Satoshi Sumiya, Lifeng Wang, Hanako Oyamada, Philip Gerald Blakeman, Michael Gavin Brown, Sougato Chatterjee, Andrew Francis Chiffey, Jane Gast, Paul Richard Phillips, Raj Rao Rajaram, Andrew Peter Walker
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Patent number: 8652430Abstract: The present invention provides an organic dispersion of inorganic platelets, which includes an organic solvent and H-form inorganic platelets dispersed therein. The H-form inorganic platelets have a particle size of between about 20 and 80 mm and the organic dispersion has a sold content of between about 1 and 20 wt %. A method for forming the organic dispersion is also provided.Type: GrantFiled: September 12, 2011Date of Patent: February 18, 2014Assignee: Industrial Technology Research InstituteInventors: Chih-Jen Yang, Chyi-Ming Leu, Chun-Wei Su
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Patent number: 8652431Abstract: A method of synthesis of a metal fluorophosphate having the following general formula (1): XaMb(PO4)cFd (1), in which: X is an alkaline metal selected among sodium (Na) and lithium (Li) or a mixture of said metals; M is a transition metal selected among the following elements: Co, Ni, Fe, Mn, V, Cu, Ti, Al, Cr, Mo, Nb or a combination of at least two of said metals, 0?a?5; 0.5?b?3; 0.5?c?3; and d is an integer equal to 1, 2 or 3. The method contains an electric-field-activated sintering process for a mixture (1) formed by at least one first phosphate-containing solid precursor and at least one second fluorine-containing solid precursor.Type: GrantFiled: November 4, 2010Date of Patent: February 18, 2014Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre Nationale de Recherche ScientifiqueInventors: Sébastien Patoux, Carole Bourbon, Erwan Dumont-Botto, Mickael Dolle, Patrick Rozier
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Patent number: 8652432Abstract: A method of producing a porous silica material includes: preparing a raw material solution containing silicon alkoxides including diisobutyldimethoxysilane and tetramethoxysilane in such a mass ratio that a mass of the diisobutyldimethoxysilane is 0.25 or more and 1 or less per mass of the tetramethoxysilane, and a solvent; obtaining a wet gel by adding, to the raw material solution, an aqueous solution containing a catalyst for promoting hydrolysis and condensation polymerization of the silicon alkoxides, the aqueous solution having a pH of 8.9 or more and 11.3 or less; washing the wet gel; and drying the washed wet gel under supercritical conditions.Type: GrantFiled: August 13, 2013Date of Patent: February 18, 2014Assignee: Panasonic CorporationInventors: Yuriko Kaneko, Takuya Iwamoto, Ushio Sangawa, Masahiko Hashimoto, Norihisa Mino
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Patent number: 8652434Abstract: The present invention discloses a compound comprising an expanded percarbonate salt having less than about 24 wt. % hydrogen peroxide. Also disclosed in this invention is a composition including the above-mentioned compound and a liquid loaded thereon. Further, there is disclosed a method of manufacturing the above-described compound.Type: GrantFiled: February 27, 2012Date of Patent: February 18, 2014Assignee: ChemLink Laboratories, LLCInventors: Ryan Giffin Moore, Joseph Matthew Garmon, Bridget Nicole Lemley
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Patent number: 8652435Abstract: An improved process for reduction-oxidation desulphurization uses an oxidizer operating at a pressure greater than the absorber where a liquid reduction-oxidation catalyst solution contacts a sulfur-containing gas feed stream.Type: GrantFiled: January 8, 2013Date of Patent: February 18, 2014Assignee: Merichem CompanyInventor: Gary J. Nagl
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Patent number: 8652436Abstract: A material for water gas contains polyhydric alcohol, and hydroxycarboxylic acid.Type: GrantFiled: November 16, 2009Date of Patent: February 18, 2014Assignee: Kao CorporationInventors: Yasuo Amishige, Takeshi Shirasawa
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Patent number: 8652437Abstract: A method of manufacturing an artificial zeolite. The method includes the steps of: heating a waste insulator to form a molten insulator; quenching and pulverizing the molten insulator; and heat treating the quenched and pulverized insulator in an alkaline aqueous solution.Type: GrantFiled: August 3, 2007Date of Patent: February 18, 2014Assignee: Prometron Technics Corp.Inventors: Teruo Henmi, Takayuki Nakamura, Toshiaki Ubukata, Hirokuni Matsuda, Shuji Tada
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Patent number: 8652438Abstract: There is provided a central nervous system labelling composition for intranasal administration for the purpose of labelling the central nervous system from the olfactory epithelium by way of the olfactory bulb and by means of intranasal administration. Additionally, there is provided a method of non-invasively labelling the central nervous system by way of an administration route that entails little transferability to the entire body. Furthermore, there is provided a screening method using a central nervous system labelling composition for intranasal administration.Type: GrantFiled: April 12, 2011Date of Patent: February 18, 2014Assignee: Canon Kabushiki KaishaInventors: Tsuyoshi Nomoto, Kohei Watanabe, Taichi Shintou, Takeshi Miyazaki, Toshio Tanaka, Yuhei Nishimura, Yasuhito Shimada
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Patent number: 8652439Abstract: The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where the peptide serves as an adjuvant as well as conjugates where the peptide is covalently linked to the viral antigen. The known synthetic peptide carrier, p458, provides significantly improved immunogenicity for synthetic viral epitopes and analogs. Ec27 is a novel peptide derived from HSP60 which increases the immunogenicity substantially of the viral antigen both as a mixture or a covalent conjugate. Some of the isolated viral epitopes are novel and are claimed for diagnostic as well as therapeutic or prophylactic uses.Type: GrantFiled: June 20, 2011Date of Patent: February 18, 2014Assignees: Yeda Research and Development Co. Ltd., B.G. Negev Technologies and Applications Ltd.Inventors: Irun R. Cohen, Bracha Rager-Zisman, Angel Porgador, Johannes Herkel
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Patent number: 8652440Abstract: The present invention relates to methods for determining whether a mammal has a disease, such as diabetes, using PET data analysis techniques. These methods include administering to a mammal a PET-compatible tracer, such as a radioligand specific for a vesicular monoamine transporter 2 (VMAT2) receptor, and measuring total functional ?-cell capacity (volume) of the mammal's pancreas using PET data analysis techniques. Methods for tracking the efficacy of a treatment for diabetes, for evaluating the regeneration of ?-cells in a pancreas, and for monitoring a patient with a transplanted pancreas are also provided.Type: GrantFiled: May 9, 2008Date of Patent: February 18, 2014Assignee: The Trustees of Columbia University in the City of New YorkInventor: Masanori Ichise
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Patent number: 8652441Abstract: A method of detecting a contrast agent for photoacoustic imaging provides a high signal intensity. In a contrast agent for photoacoustic imaging, each particle containing an inorganic material supports at least an organic dye having an absorption coefficient in the near infrared region by means of chemical bonding.Type: GrantFiled: September 29, 2010Date of Patent: February 18, 2014Assignee: Canon Kabushiki KaishaInventors: Tatsuki Fukui, Fumio Yamauchi, Satoshi Yuasa, Sachiko Inoue
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Patent number: 8652442Abstract: Methods of imaging distribution of myeloperoxidase activity in a subject are disclosed. These methods include the use of bioluminescent substrates, including luminol and wavelength-shifted analogues of luminol. Bioluminescent myeloperoxidase substrates that emit light at longer wavelengths compared to luminol are shown to be useful for imaging myeloperoxidase activity in vivo. The disclosed methods can be used for imaging sites of inflammation and other pathological conditions associated with abnormal levels of MPO activity in vivo. Methods of synthesis of luminol analogues are also disclosed.Type: GrantFiled: November 3, 2009Date of Patent: February 18, 2014Assignee: Washington UniversityInventors: David Piwnica-Worms, Shimon Gross, Vijay Sharma, Seth Gammon
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Patent number: 8652443Abstract: Described are ethanol-free foamable microemulsions for topical application, and method of making them. The propellants used in the compositions may be environmentally-friendly hydrofluoroalkanes. The foam compositions may also comprise one or more of a variety of active ingredients, including anti-inflammatory agents, anesthetics, and keratolytic agents.Type: GrantFiled: February 13, 2009Date of Patent: February 18, 2014Assignee: Precision Dermatology, Inc.Inventors: Ravi K. Varanasi, Roman V. Rariy
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Patent number: 8652444Abstract: Antiplaque oral compositions are provided that contain an orally acceptable carrier and an antibacterial effective amount of the compound of formula (I). In various embodiments, the compositions contain from about 0.001% to about 10% by weight of the compound of formula (I).Type: GrantFiled: November 9, 2011Date of Patent: February 18, 2014Assignee: Colgate-Palmolive CompanyInventors: Ravi Subramanyam, Prem Sreenivasan
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Patent number: 8652445Abstract: A one-component prescription fluoride treatment composition having both fluoride efficacy and sensitivity relief is disclosed. The composition includes at least one metal fluoride and a nerve desensitizing agent such as potassium nitrate. The invention further includes a composition having at least one metal fluoride less than about 1.15% by weight of at least one metal fluoride; less than about 5 percent by weight of at least one alkali metal salt having desensitizing effect; at least one carrier; and at least one foaming agent that has thickening property. The composition may be formulated into a gel, a paste or any other convenient form, some of which contain abrasives.Type: GrantFiled: June 30, 2005Date of Patent: February 18, 2014Assignee: Discus Dental, LLCInventors: Jeff MacDonald, Robert Hayman
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Patent number: 8652446Abstract: Disclosed herein is a pair of dry type patches for teeth whitening, having a patch for upper teeth and a patch for lower teeth, in which the patch for upper teeth has a shape different from the patch for lower teeth, and each patch has a controlled width and shape such that the contact area of each patch with gums is minimized. In the patch for upper teeth, a central portion covering right and left upper central incisors is widest. In the patch for lower teeth, either portion covering right and left lower canine teeth is widest. Since the dry type patches covers all the portions of the teeth while minimizing the contact area with gums, no or little irritation is caused and wearability is excellent.Type: GrantFiled: November 19, 2003Date of Patent: February 18, 2014Assignee: LG Household & Healthcare Ltd.Inventors: Ji-Young Kim, Jong-Ho Kim, Sug-Youn Chang, Sei-Young Yun, Hae-Young Yang, Sang-Hoon Kwak
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Patent number: 8652447Abstract: The invention provides for cosmetic and personal care compositions comprising a synthetic magnesium aluminosilicate clay. The synthetic magnesium aluminosilicate clay is formed at ambient pressure by a series of reaction steps and a pH change from acidic pH to basic pH. The characteristics of the magnesium aluminosilicate clay, including platelet size, degree of stacking, and porosity can be tuned depending on the cosmetic or personal care product desired. In addition, these cosmetic and personal care compositions optionally include one or more of the following components: odor controlling agents, skin protectants, diluents, lipophilic skin health benefit agents, sunscreens, humectants, emollients, slip compounds, and moisturizers.Type: GrantFiled: December 18, 2008Date of Patent: February 18, 2014Assignee: Chevron U.S.A. Inc.Inventors: Theodorus Maesen, Alexander E. Kuperman, Ibrahim J. Uckung
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Patent number: 8652448Abstract: Hydrogel particles include: a continuous phase of non-crosslinked hydrogel; and a dispersed phase dispersed in the continuous phase. The dispersed phase includes a crystalline organic UV absorber and a solid fat having an organic value (OV) of 310 or more and an inorganic value (IV) of 130 or more on an organic conceptual diagram. The content of the crystalline organic UV absorber in the dispersed phase is 15-70 mass %.Type: GrantFiled: December 16, 2010Date of Patent: February 18, 2014Assignee: Kao CorporationInventors: Yuka Onishi, Kimikazu Fukuda, Kazuo Matsuyama, Koji Mine
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Patent number: 8652449Abstract: The disclosure relates to sunscreen compositions having a synergistic combination of ultraviolet light (UV) filtering agents that provide a high sun protection factor (SPF). Compositions according to the disclosure have high SPF values without requiring high overall amounts of UV filtering agents. Furthermore, the disclosure relates to methods of using the described compositions for protecting keratinous substances such as skin and hair from UV radiation.Type: GrantFiled: December 19, 2012Date of Patent: February 18, 2014Assignee: L'OrealInventors: Susan Halpern, Jean-Thierry Simonnet, Anil Shah, Didier Candau, Angélina Roudot
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Patent number: 8652450Abstract: The invention relates to soap-based liquid body and facial wash compositions. Using high solvent, low water compositions and incompletely naturalized fatty acids to help structure the compositions, all in combination with modified benefit agents, enhanced deposition of conditioning and/or skin appearance and/or optical enhancing agents is achieved.Type: GrantFiled: October 21, 2008Date of Patent: February 18, 2014Assignee: Conopco, Inc.Inventors: Joseph Oreste Carnali, Pravin Shah, Qiang Qiu
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Patent number: 8652451Abstract: The invention relates to a composition comprising a oil-soluble polar modified polymer and a sugar silicone surfactant.Type: GrantFiled: June 29, 2010Date of Patent: February 18, 2014Assignee: L'OrealInventors: Hy Si Bui, Mohamed Kanji, Anita Chon Tong, Chunhua Li, Bruno Bavouzet, Susan Halpern
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Patent number: 8652452Abstract: The present invention relates to the field of perfumery. More particularly, it concerns the use as perfuming ingredients of a 2,4-dialkyl-pyridine of formula (I): in the form of any one of its stereoisomers or a mixture thereof, wherein R1 represents a C1-3 alkyl group; R2 represents a C4-9 linear alkyl group; and the compound has between 10 and 15 carbon atoms. These compounds are useful for imparting odors of the green and/or pyrazine type. The present invention concerns the use of such compounds in the perfumery industry as well as the compositions or articles containing them.Type: GrantFiled: March 10, 2011Date of Patent: February 18, 2014Assignee: Firmenich SAInventors: Estelle Delort, Kirk F. Eidman
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Patent number: 8652453Abstract: A new hair cosmetic composition containing (a) a 40-90 wt % volatile oil component, (b) 0.1-20 wt % a combination of polyoxyethylene, polyoxypropylene, butylene, dimethylpolysiloxane copolymers, and (c) 0.1-30 wt % ethanol. This hair cosmetic composition may be mainly used in a hair oil for superior sensation during use and superior stability over time.Type: GrantFiled: November 16, 2010Date of Patent: February 18, 2014Assignee: Shiseido Company, Ltd.Inventors: Keiko Nakamura, Taizo Fujiyama