Patents Issued in April 3, 2014
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Publication number: 20140094589Abstract: The invention relates to the field of biotechnology and provides a method for producing recombinant proteins from the orb-weaving spider silk in yeast cells. This involves the construction of an expression vector which comprises a DNA sequence encoding a recombinant protein of the orb-weaving spider silk fused with a sequence encoding an ubiquitin-like protein occupying an N-terminal position with respect to the spider silk recombinant protein within the fused protein. The expression of a hybrid gene makes it possible to increase tens of times the production of recombinant spider silk protein, wherein the recombinant protein accumulates in the yeast cells in a water-insoluble fraction in the form of a processed protein free of a hybrid component.Type: ApplicationFiled: December 13, 2010Publication date: April 3, 2014Inventors: Vladimir Grigorievich Bogush, Mihail Yurievich Beburov, Vladimir Georgievich Debabov, Dmitriy Georgievich Kozlov, Irek Ilyasovich Gubaydullin, Lyubov Ivanovna Davydova, Igor Arsenievich Zalunin, Konstantin Vasilievich Sidoruk, Sergey Eduardovich Cheperegin
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Publication number: 20140094590Abstract: It is an object of the present invention to provide a protein having high cellular adhesiveness that is useful as a cell adhesion support. The present invention provides a cell-adhesive protein comprising methionine, wherein at least a portion of the methionine residues is oxidized.Type: ApplicationFiled: September 27, 2013Publication date: April 3, 2014Applicant: Fujifilm CorporationInventor: Kazutaka OGIWARA
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Publication number: 20140094591Abstract: This invention relates to protein separation and purification methods for both alpha-1-antitrypsin (AAT, also known as alpha-1 proteinase inhibitor, API, and A.sub.1-PI) and Apolipoprotein A-I (ApoA-1) from, for example, a fraction of human blood plasma. In certain embodiments, the invention provides methods for separating AAT from ApoA-1 at the initial stage of purification, so that the same starting material can be used as a source for both proteins. The methods further pertain to providing compositions of AAT and of ApoA-1 suitable for pharmaceutical use and are suitable for large-scale purification.Type: ApplicationFiled: December 3, 2013Publication date: April 3, 2014Applicant: CSL Behring GmbHInventors: Nathan Brinkman, Douglas Bigler, Reinhard Bolli, Vreni Foertsch
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Publication number: 20140094592Abstract: The present invention provides novel, modified pokeweed antiviral proteins, nucleic acids that encode the proteins, conjugates that incorporate the proteins, and methods to make and use the proteins. The present invention also provides methods to administer the conjugates to animals, for the purpose of directing toxin to particular cells.Type: ApplicationFiled: October 3, 2013Publication date: April 3, 2014Applicants: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION, CEDUS, INC.Inventors: Eric R. Weber, Torrance M. Nett
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Publication number: 20140094593Abstract: The invention provides a washing method for affinity chromatography in which a wash solution comprising arginine, or an arginine derivative, at pH greater than 8.0, is effective in removing impurities without the presence of a nonbuffering salt, while simultaneously increasing product concentration in the eluate and maintaining a high percent yield of recovered product.Type: ApplicationFiled: May 31, 2012Publication date: April 3, 2014Applicant: Novartis AGInventor: Achim Frauenschuh
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Publication number: 20140094594Abstract: The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS3 analysis, or the step of (e) utilizing a search program to substantially match the spectra obtained for the modified peptide during the characterization of step (d) with the spectra for a known peptide sequence, thereby identifying the parent protein(s) of the modified peptide.Type: ApplicationFiled: April 23, 2013Publication date: April 3, 2014Inventor: Cell Signaling Technology, Inc.
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Publication number: 20140094595Abstract: Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.Type: ApplicationFiled: September 10, 2013Publication date: April 3, 2014Applicant: Bristol-Myers Squibb CompanyInventors: Dasa LIPOVSEK, Richard W. Wagner, Robert G. Kuimelis
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Publication number: 20140094596Abstract: The present invention relates to a sorbent material for separation and purification of biopolymers, particularly nucleic acids, having a solid support substantially modified with a copolymer coating comprising aromatic monomers and crosslinking compounds and unsaturated esters or ethers preferably attached to the support via a vinylchlorsilane. The use of these materials for separation of nucleic acids, particularly a one-step isolation of DNA from lysates of different biological sources, is an object of the invention as well as a chromatographic column or cartridge at least partially filled with the sorbent material of the invention, a membrane-like device comprising the sorbent material of the invention, and a kit comprising the sorbent material of the invention in bulk or packed in chromatographic devices as well as other devices necessary for performing sample preparations.Type: ApplicationFiled: September 20, 2013Publication date: April 3, 2014Applicant: NExtTec GmbHInventors: Hamlet Balayan, Robert-Matthias Leiser, Lutz Plobner, Leonti E. Tkachenko, Gottfried Brem
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Publication number: 20140094597Abstract: The present invention provides a method of isolating nucleic acid from a sample, said method comprising contacting said sample with a solid support, preferably magnetic beads, in the presence of an ethylene glycol multimer consisting of from 2 to 70 ethylene oxide monomers, preferably tetraethylene glycol, whereby soluble nucleic acid in said sample is bound to the surface of the support, and separating said support with bound nucleic acid from the sample. Kits for performance of the invention are also provided.Type: ApplicationFiled: September 24, 2013Publication date: April 3, 2014Applicant: LIFE TECHNOLOGIES ASInventor: Erling FINNE
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Publication number: 20140094598Abstract: A method of preparing purified decitabine comprises mixing crude decitabine with solvent, such as dimethylacetamide, to form a solution or suspension and forming the purified decitabine from the solution or suspension. The forming step comprises adding an anti-solvent, such as ethanol, to the solution or suspension. The forming step may further comprise after adding ethanol to provide a mixture of dimethylacetamide and ethanol: cooling the mixture; isolating the solid decitabine present in the cooled mixture; and evaporating residual dimethylacetamide and ethanol from the solid decitabine to provide the purified decitabine. The mixture of dimethylacetamide and ethanol may be heated. The purification method preferably results in decitabine having a ratio of the ?-anomer of decitabine to the ?-anomer of decitabine of at least about 99.9:0.1.Type: ApplicationFiled: September 30, 2013Publication date: April 3, 2014Applicant: Johnson Matthey Public Limited CompanyInventor: Daniel James Coughlin
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Publication number: 20140094599Abstract: Non-ionic water-soluble cellulose ethers modified with 3-azido-2-hydroxypropyl groups bound via an ether link are provided having a molar degree of substitution MSAHP in the range from 0.001 to 0.50. Exemplary cellulose ethers are alkyl celluloses, including methyl, hydroxyalkyl (e.g. hydroxyetbyl or hydroxypropyl) or alkylhydroxyalkyl cellulose (e.g. methylhydroxyethyl). Reaction products with alkyne compounds are also provided, resulting in a terminal alkyne group. The reaction of azide with the alkyne proceeds as a 1,3-dipolar cycloaddition reaction, advantageously with Cu(I) or ruthenium catalysts. A multiplicity of cellulose ethers can be obtained from the conversion reaction. Variations in the macroscopic properties can be achieved by controlled modification, ranging from increased or reduced viscosity. The reaction, taking place within a few seconds, requires only minimal catalyst.Type: ApplicationFiled: September 18, 2013Publication date: April 3, 2014Inventor: Mike KLEINERT
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Publication number: 20140094600Abstract: A process for the preparation of compound of Formula (I) is provided.Type: ApplicationFiled: March 12, 2012Publication date: April 3, 2014Applicant: WOCKHARD LIMITEDInventors: Kiran Kumar Gangakhedkar, Furqan Mohammed Diwan, Aniruddha Varangaonkar, Keshav Deo
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Publication number: 20140094601Abstract: A sulfonated dye salt is disclosed. The sulfonated dye salt has a phosphazene cation of formula (C): wherein: R15, R16 and R17 are each independently selected from the group consisting of: C6-12 aryl, C5-12 heteroaryl; N(R20)(R21) and —N?P[N(R22)2]3; R18 and R19 are each independently selected from the group consisting of: H and C1-8 alkyl; or R18 and R19 are together: ?P(Ph)3; R20 and R21 are each independently selected from the group consisting of: H and C1-8 alkyl; or R20 and R21 are together joined to form a nitrogen-containing C5-10 heterocycloalkyl group; and R22 is C1-6 alkyl.Type: ApplicationFiled: October 1, 2012Publication date: April 3, 2014Inventors: Sutharsiny Indusegaram, Graciel Gonzaga, Simone Charlotte Vonwiller, Scott Matthew Starling, Lachlan Everett Hall, Damon Donald Ridley, Kia Silverbrook
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Publication number: 20140094602Abstract: Described is pentamycin in a purity exceeding 95%, certain polymorphs and solvates of pentamycin, processes for their manufacture, and a method for decreasing the rate of degradation of pentamycin.Type: ApplicationFiled: July 22, 2013Publication date: April 3, 2014Applicant: Biolotus Biotechnology AGInventors: Karl REUTER, Victor Meier, Florian Stolz, Dieter Krimmer, Cees Winninps
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Publication number: 20140094603Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.Type: ApplicationFiled: December 6, 2013Publication date: April 3, 2014Applicant: ARRAY BIOPHARMA INC.Inventors: Jeremy Hans, Eli M. Wallace, Qian Zhao, Joseph P. Lyssikatos, Thomas D. Aicher, Ellen R. Laird, John Robinson, Shelley Allen
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Publication number: 20140094604Abstract: The present invention is related to new intermediates and processes for preparing Ticagrelor disclosed in this patent application.Type: ApplicationFiled: April 6, 2012Publication date: April 3, 2014Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD.Inventors: Vinod Kumar Kansal, Dhirenkumar Mistry, Sanjay Vasoya, Ghanshyam Pandey, Amlt Taneja, Pramond Kadappa, Jiri Stohandl, Jaroslay Frantisek
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Publication number: 20140094605Abstract: A synthesis approach providing an early ring attachment via a bromination to compound I-I yielding compound II-II: whereby a final product such as AA: can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.Type: ApplicationFiled: December 4, 2013Publication date: April 3, 2014Applicants: ViiV Healthcare Company, Shionogi & Co., Ltd.Inventors: Hiroshi YOSHIDA, Yoshiyuki TAODA, Brian Alvin JOHNS, Takashi KAWASUJI, Daiki NAGAMATSU
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Publication number: 20140094606Abstract: A ruthenium complex for a dye-sensitized solar cell includes a chemical formula represented by Formula (I): RuL1L2L3??(I) where L1 represents a monodentate ligand; L2 represents a tridentate ligand of and L3 represents a bidentate ligand of where R1 to R27 have meaning as defined in the specification.Type: ApplicationFiled: December 4, 2013Publication date: April 3, 2014Applicant: National Tsing Hua UniversityInventors: Yun CHI, Chun-Cheng CHOU, Fa-Chun HU, Sheng-Wei WANG
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Publication number: 20140094607Abstract: The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate; wherein said system is substantially free of a transition-metal compound.Type: ApplicationFiled: October 2, 2013Publication date: April 3, 2014Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: ROBERT H. GRUBBS, ALEXEY FEDOROV, ANTON TOUTOV, KERRY BETZ
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Publication number: 20140094608Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.Type: ApplicationFiled: September 18, 2013Publication date: April 3, 2014Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Wai-Yee LEUNG, Ching-Ying Cheung, Stephen Yue
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Publication number: 20140094609Abstract: The present invention is directed to an improved process for the preparation of Compounds of Formula (I), which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid, which is useful in the treatment of HIV infection.Type: ApplicationFiled: October 2, 2013Publication date: April 3, 2014Inventors: Brandon H. Brown, Xiang Wang, Keith R. Fandrick, Joe Ju Gao, Nizar Haddad, Serge R. Landry, Wenjie Li, Zhi-Hui Lu, Bo Qu, Diana C. Reeves, Carl Thibeault, Yongda Zhang
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Publication number: 20140094610Abstract: The present invention is directed to an improved process for the preparation of Compounds of Formula (I) or salts thereof which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid or salt thereof which is useful in the treatment of HIV infection.Type: ApplicationFiled: October 3, 2013Publication date: April 3, 2014Inventors: Wenjie LI, Philomen DECROOS, Keith R. FANDRICK, Joe Ju GAO, Nizar HADDAD, Zhi-Hui LU, Bo QU, Sonia RODRIGUEZ, Chris H. SENANAYAKE, Yongda ZHANG, Wenjun TANG
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Publication number: 20140094611Abstract: Provided herein are intermediates and processes useful for facile synthesis of biologically active molecules.Type: ApplicationFiled: March 11, 2013Publication date: April 3, 2014Inventor: Prabha N. Ibrahim
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Publication number: 20140094612Abstract: The present invention relates to novel metathesis catalysts with an imidazolidine-based ligand and to methods for making and using the same. The inventive catalysts are wherein: M is ruthenium or osmium; X and X1 are each independently an anionic ligand; L is a neutral electron donor ligand; and, R, R1R6, R7, R8, and R9 are each independently hydrogen or a substituent selected for the group consisting of C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20 alkoxycarbonyl, C1-C20 alkylthiol, aryl thiol, C1-C20 alkylsulfonyl and C1-C20 alkylsulfinyl, the substituted optionally substituted with one or more moieties selected from the group consisting of C1-C20 alkyl, C1-C10 alkoxy, aryl, and a functional group. The inclusion of an imidazolidine ligand to the previously described ruthenium or osmium catalysts has been found to dramatically improve the properties of these complexes.Type: ApplicationFiled: November 15, 2013Publication date: April 3, 2014Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Robert H. Grubbs, Matthias Scholl
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Publication number: 20140094613Abstract: A process for producing a 3-alkoxy-2-amino-6-fluoro bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative represented by the formula (I) or a salt thereof, which includes converting a compound represented by the formula (VI) or a salt thereof to the compound represented by the formula (I) or a salt thereof.Type: ApplicationFiled: December 5, 2013Publication date: April 3, 2014Applicant: TAISHO PHARMACEUTICAL CO., LTD.Inventors: Noriaki MURASE, Toshihito KUMAGAI, Hisaya WADA, Hisahide TANIMOTO, Koumei OHTA, Yoshihiro KIMURA
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Publication number: 20140094614Abstract: The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.Type: ApplicationFiled: December 10, 2013Publication date: April 3, 2014Applicant: Allergan, Inc.Inventors: Richard L. Beard, Tien T. Duong, John E. Donello, Veena Viswanath, Michael E. Garst
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Publication number: 20140094615Abstract: Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.Type: ApplicationFiled: April 26, 2012Publication date: April 3, 2014Applicant: The Board of Trustees of the University of IllinoisInventors: Martin D. Burke, Junqi Li, Eric P. Gillis
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Publication number: 20140094616Abstract: Compound (1) or a salt that is useful as an intermediate for the production of a medicine, an agrochemical or the like can be produced by a process including the following steps: (A) reacting an aldehyde (2) with nitromethane to produce a nitroaldehyde; (B) reacting the nitroaldehyde with an alcohol to produce a nitroacetal; (C) reducing the nitroacetal to produce an aminoacetal; (D) protecting an amino group in the aminoacetal to produce a protected aminoacetal; (E) treating the protected aminoacetal with an acid and subsequently with a base and then reacting the resultant product with a cyanating agent to produce a nitrile; (F) hydrolyzing the nitrile to produce a protected amino acid; and (G) substituting a group R5 in the protected amino acid by a hydrogen atom and protecting a carboxyl group therein.Type: ApplicationFiled: May 17, 2012Publication date: April 3, 2014Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Tetsuya Ikemoto, Leopold Mpaka Lutete, Toshiaki Aikawa
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Publication number: 20140094617Abstract: A chemical reactor including: a plurality of heat exchange plates which between them define reaction compartments, in which reactor each heat exchange plate includes two walls between them defining at least one heat exchange space, the respective walls being fixed together by joining regions, and the reactor also comprises at least one injection device for injecting substance into the reaction compartments, said substance-injection device passing through the heat-exchange plates in respective joining regions thereof. Also, a chemical reaction process that can be carried out in this reactor.Type: ApplicationFiled: June 1, 2012Publication date: April 3, 2014Applicant: ARKEMA FRANCEInventor: Jean-Luc Dubois
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Publication number: 20140094618Abstract: Described is a method to make liquid chemicals. The method includes deconstructing cellulose to yield a product mixture comprising levulinic acid and formic acid, converting the levulinic acid to ?-valerolactone, and converting the ?-valerolactone to pentanoic acid. Alternatively, the ?-valerolactone can be converted to a mixture of n-butenes. The pentanoic acid can be decarboxylated yield 1-butene or ketonized to yield 5-nonanone. The 5-nonanone can be hydrodeoxygenated to yield nonane, or 5-nonanone can be reduced to yield 5-nonanol. The 5-nonanol can be dehydrated to yield nonene, which can be dimerized to yield a mixture of C9 and C18 olefins, which can be hydrogenated to yield a mixture of alkanes.Type: ApplicationFiled: December 2, 2013Publication date: April 3, 2014Applicant: Wisconsin Alumni Research FoundationInventors: James A. Dumesic, Juan Carlos Serrano Ruiz, Ryan M. West
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Publication number: 20140094619Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.Type: ApplicationFiled: August 23, 2013Publication date: April 3, 2014Applicants: US GOV BY THE SEC. OF DEPT. OF HEALTH & HUMAN SERV, RESEARCH TRIANGLE INSTITUTEInventors: Scott P. RUNYON, Michael ROGAWSKI, Edgar COOK, John KEPLER, Hernan NAVARRO, Rafal KAMINSKI, Matthew ORR
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Publication number: 20140094620Abstract: The present invention discloses a phosphorus-silicon synergistic flame retardant and the preparation method and use thereof. The phosphorus-silicon synergistic flame retardant provided by the present invention has a structural general formula shown as formula I. A new type of compound containing phosphorus and silicon is prepared by the present invention using the cheap organic boron catalyst, and employing the addition reaction of diphenyl phosphine oxide and derivatives thereof with silicone containing carbon-carbon double bond. Such compounds have the properties of hydrolytic resistance, easy purification, and low synthesis cost, etc. Phosphorus and silicon elements in the molecular structures of such compounds both can act as the flame retardants solely, and meantime can work synergistically, thereby enduing the common polymeric materials with the excellent flame retardant property.Type: ApplicationFiled: April 13, 2012Publication date: April 3, 2014Applicant: INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCESInventors: Shiyong Yang, Tao Song, Jingang Liu
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Publication number: 20140094621Abstract: The present invention provides a method for preparing dialkyl carbonate from urea or alkyl carbamate and alkyl alcohol using an ionic liquid comprising a cation, which produces a hydrogen ion, and a hydrophobic anion containing fluorine with high temperature stability in the presence of catalyst containing a metal oxide or hydrotalcite. Since the present invention can prepare dialkyl carbonate at a pressure lower than those of existing methods, it does not require an expensive pressure control device and peripheral devices for maintaining high pressure including the installation cost. It is also the method for preparing a dialkyl carbonate with high yield, thus improving economical efficiency. Moreover, the method of the present invention hardly produces any waste during the process and is thus an eco-friendly method.Type: ApplicationFiled: December 9, 2013Publication date: April 3, 2014Applicant: RESEARCH INSTITUTE OF INDUSTRIAL SCIENCE & TECHNOLOGYInventors: Jae Cheon KOH, Chul Ung Kim, Yun Min Kim
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Publication number: 20140094622Abstract: A method of producing methyl acetate from methanol in which methanol and carbon monoxide are reacted in a first reaction zone to provide a reaction product including methyl acetate, acetic acid, and unreacted methanol. The reaction product then is passed to a second reaction zone, wherein the acetic acid is reacted with the unreacted methanol to provide additional methyl acetate. The method is a more efficient method for producing methyl acetate from methanol in that acetic acid is not separated from the reaction product.Type: ApplicationFiled: October 2, 2012Publication date: April 3, 2014Inventors: Stephane MARIE-ROSE, Esteban CHORNET
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Publication number: 20140094623Abstract: The problem to be solved by the present invention is to provide a method for producing a compound having excellent activity as an ?2? ligand.Type: ApplicationFiled: December 9, 2013Publication date: April 3, 2014Applicant: Daiichi Sankyo Company, LimitedInventor: Yoshitaka Nakamura
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Publication number: 20140094624Abstract: The problem to be solved is to provide a method for producing a compound having excellent activity as an ?2? ligand.Type: ApplicationFiled: December 9, 2013Publication date: April 3, 2014Applicant: Daiichi Sankyo Company, LimitedInventors: Yoshitaka Nakamura, Kenichi Kimura
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Publication number: 20140094625Abstract: The present invention relates to improved processes for the production of 2-amino-2-[2-(4-C2-20 alkyl-phenyl)ethyl]propane-1,3-diols, and to compounds for use therein.Type: ApplicationFiled: November 8, 2013Publication date: April 3, 2014Applicant: NOVARTIS AGInventor: Gottfried Sedelmeier
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Publication number: 20140094626Abstract: The invention provides a method for coating fluidic channels, particularly millifluidic channels, with a catalyst coating having controlled dimensions and morphology, and methods for preparing such channels, and devices that can be used in combination with the channels. The invention further provides portable, hand-held millifluidic devices applicable for a wide variety of uses including molecular reduction reactions, in situ material characterization, in situ reaction catalysis characterization, in situ reaction mechanism characterization, nanomaterial synthesis, nanostructured metal and metal oxide growth and coating of channels, continuous flow cell culturing, enzymatic catalysis, biomolecular catalysis, combinatorial chemistry, reactions involving homogeneous catalysts bound to channel walls, peptide synthesis, nucleic acid synthesis, synthesis of pharmaceutical intermediates, biofunctionalization of nanomaterials or a combination thereof.Type: ApplicationFiled: September 19, 2013Publication date: April 3, 2014Inventor: Siva Sai Ramana Kumar CHALLA
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Publication number: 20140094627Abstract: A method for producing a 4,4?-diformyldiphenylalkane represented by the following formula (2), containing formylating a diphenylalkane represented by the following formula (1) with carbon monoxide in the presence of hydrogen fluoride and boron trifluoride, in which the reaction temperature of the formylation is from ?50 to 5° C., from 5 to 30 mol of hydrogen fluoride is used per 1 mol of the diphenylalkane, and from 1.5 to 5 mol of boron trifluoride is used per 1 mol of the diphenylalkane: wherein R represents an alkanediyl group having from 1 to 6 carbon atoms, wherein R represents an alkanediyl group having from 1 to 6 carbon atoms.Type: ApplicationFiled: March 29, 2012Publication date: April 3, 2014Applicant: MITSUBISHI GAS CHEMICAL COMPANY INCInventor: Mitsuharu Kitamura
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Publication number: 20140094628Abstract: The subject of the present invention is a method for separating phenolic compounds in salified form from a reaction medium comprising them. The method of the invention for separating phenolic compounds in salified form from an aqueous reaction medium resulting from the reaction of a phenolic compound and of glyoxylic acid in the presence of a base leading to a reaction medium comprising at least the excess of initial phenolic compound in salified form and the various mandelic compounds in salified form resulting from the reaction, is characterized by the fact that said reaction medium is brought into contact with a basic anion-exchange resin that leads to the selective attachment of the initial phenolic compound to said resin and to the recovery of an aqueous stream comprising the mandelic compounds in salified form resulting from the reaction, and that the phenolic compound in salified form attached to the resin is separated by a resin regeneration treatment.Type: ApplicationFiled: December 6, 2013Publication date: April 3, 2014Applicant: Rhodia OperationsInventor: Magali DESOUHANT-MASSACRET
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Publication number: 20140094629Abstract: Purification and/or recovery of ethanol from a crude ethanol product obtained from the hydrogenation of acetic acid. Separation and purification processes of a crude ethanol mixture are employed to allow recovery of ethanol and remove impurities. In particular, the process involves one or more sidedraws to regulate C3+ alcohols concentration in the recovered ethanol.Type: ApplicationFiled: December 6, 2013Publication date: April 3, 2014Applicant: Celanese International CorporationInventors: Lincoln Sarager, Wael Amleh, Trinity Horton Hale, Radmila Wollrab, Victor J. Johnston
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Publication number: 20140094630Abstract: Provided herein are processes comprising providing a fermentation medium comprising a fermentable carbon source, a recombinant microorganism comprising an engineered butanol biosynthetic pathway, and butanol; contacting said fermentation medium with an extractant composition comprising an effective amount of antioxidant or antioxidant-like compound, whereby at least a portion of the butanol in the fermentation medium partitions into the extractant; recovering at least a portion of the butanol and extractant composition from the fermentation medium; recycling the extractant composition recovered in (c) one or more times in the fermentation medium; optionally adjusting the effective amount of antioxidant or antioxidant-like compound in the extractant composition, whereby the rate of oxidation or effect of oxidized products in the recycled extractant composition is substantially reduced and/or avoided such that the extractant composition may be recycled.Type: ApplicationFiled: September 20, 2013Publication date: April 3, 2014Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLCInventors: DOUGLAS ROBERT ANTON, BRUCE A. DINER, STEVEN D. DOIG
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Publication number: 20140094631Abstract: A process is disclosed for making styrene by converting methanol to formaldehyde in a reactor then reacting the formaldehyde with toluene to form styrene in a separate reactor.Type: ApplicationFiled: December 2, 2013Publication date: April 3, 2014Applicant: FINA TECHNOLOGY, INC.Inventors: James R. Butler, Joseph E. Pelati
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Publication number: 20140094632Abstract: Methods and apparatuses for recovering normal hexane from a reformate stream are provided. In one example, a method for recovering normal hexane from a reformate stream includes extracting aromatics from the reformate stream to form an aromatic extract stream and a raffinate stream. In the method, the normal hexane is separated from the raffinate stream to form a normal hexane product stream.Type: ApplicationFiled: September 28, 2012Publication date: April 3, 2014Applicant: UOP LLCInventor: David James Shecterle
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Publication number: 20140094633Abstract: A process for transalkylation of polyalkylated aromatic components can include providing a transalkylation reaction zone containing a transalkylation catalyst. A feedstock can be introduced into an inlet of the transalkylation reaction zone and into contact with the transalkylation catalyst. The feedstock can include a polyalkylated aromatic component derived from an aromatic substrate. The aromatic substrate can be supplied to the transalkylation reaction zone. The transalkylation reaction zone can be operated at temperature and pressure conditions sufficient to cause disproportionation of the polyalkylated aromatic component to produce a disproportionation product having a reduced polyalkylated aromatic content and an enhanced monoalkylated aromatic content. The disproportionation product can be withdrawn from the transalkylation reaction zone. Amounts of nitrogen containing compounds in the aromatic substrate can be monitored in a range of from 15 to 35 wppm by dry colorimetry.Type: ApplicationFiled: December 5, 2013Publication date: April 3, 2014Applicant: TOTAL PETROCHEMICALS FRANCEInventor: Jean-Bernard Cary
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Publication number: 20140094634Abstract: The invention describes a radial bed catalytic conversion unit having an outer cylindrical chamber (1), an inner chamber (2) which is also cylindrical, the annular zone included between the outer chamber and the inner chamber, termed the reaction zone (1), being filled with catalyst under slow gravitational flow, and the feed being introduced via an inlet pipe (E), connected to an intermediate box (F) which is in turn connected to a plurality of distribution tubes (3) disposed inside the reaction zone (I) in the vicinity of the outer chamber (1).Type: ApplicationFiled: December 6, 2013Publication date: April 3, 2014Applicant: IFP Energies NouvellesInventors: Eric SANCHEZ, Gilles FERSCHNEIDER, Frederic BAZER-BACHI
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Publication number: 20140094635Abstract: Embodiments include metal catalyst compositions and methods of forming metal catalyst compositions.Type: ApplicationFiled: May 24, 2012Publication date: April 3, 2014Inventors: Junling Lu, Peter Stair, Baosong Fu, Harold H. Kung, Mayfair C Kung
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Publication number: 20140094636Abstract: The present invention relates generally to processes for preparing agglomerated particulate low-rank coal feedstocks of a particle size suitable for reaction in a fluidized-bed reactor and certain other gasification reactors and, in particular, for coal gasification and combustion applications. The present invention also relates to an integrated coal hydromethanation process including preparing and utilizing such agglomerated particulate low-rank coal feedstocks.Type: ApplicationFiled: September 27, 2013Publication date: April 3, 2014Applicant: GreatPoint Energy, Inc.Inventors: Earl T. Robinson, Kenneth P. Keckler, Pattabhi K. Raman, Avinash Sirdeshpande
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Publication number: 20140094637Abstract: An example particle accelerator may include the following: a voltage source to sweep a radio frequency (RF) voltage in a cavity to accelerate particles from a plasma column, where the cavity has a magnetic field causing particles accelerated from the plasma column to move orbitally within the cavity, and where the magnetic field has flux that bows at edges of the cavity; a regenerator to provide a magnetic field bump within the cavity to thereby change successive orbits of the particles accelerated from the plasma column so that, eventually, particles output to an extraction point, where the regenerator is located at a radius in the cavity relative to the plasma column; and ferromagnetic arrangements located in the cavity proximate to the radius, where each ferromagnetic arrangement provides a magnetic field bump, and where ferromagnetic arrangements adjacent to the regenerator are separated from the regenerator by a space.Type: ApplicationFiled: September 27, 2013Publication date: April 3, 2014Applicant: Mevion Medical Systems, Inc.Inventors: Gerrit Townsend Zwart, Kenneth P. Gall, Jan Van der Laan, Charles D. O'Neal, III, Ken Yoshiki Franzen
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Publication number: 20140094638Abstract: In an example, a synchrocyclotron includes a particle source to provide pulses of ionized plasma to a cavity; a voltage source to provide a radio frequency (RF) voltage to the cavity to accelerate particles from the plasma column outwardly; and an extraction channel to receive a beam of particles from the cavity for output from the particle accelerator. The particle source is configured to control pulse widths of the ionized plasma in order to control an intensity of the beam of particles. This example synchrocyclotron may include one or more of the following features, either alone or in combination.Type: ApplicationFiled: September 27, 2013Publication date: April 3, 2014Applicant: Mevion Medical Systems, Inc.Inventors: Kenneth P. Gall, Gerrit Townsend Zwart, Jan Van der Laan, Adam C. Molzahn, Charles D. O'Neal, III, Thomas C. Sobczynski, James Cooley