Abstract: A mounting mat for an exhaust gas treatment device includes a blend of inorganic fibers and organic nanofibrillated fibers. An exhaust gas treatment device includes a housing and a fragile structure mounted within the housing by the mounting mat that is disposed in a gap between the housing and the fragile catalyst support structure. Additionally disclosed are methods of making a mounting mat for an exhaust gas treatment device and for making an exhaust gas treatment device incorporating the mounting mat.

Abstract: A system for rejecting heat from equipment using endothermic isomerization. includes a heat exchanger configured to receive an elevated-temperature process fluid and an isomerization compound capable of endothermic isomerization. When the system is in operation, heat from the elevated temperature process fluid is transferred to the isomerization compound and the isomerization compound endothermically isomerizes to a higher energy state form. A vehicle includes an engine and a body. The body houses a catalytic heat exchanger having an output in fluid communication with the engine, a pump for urging an isomerization compound into the heat exchanger, and a heat sink controller for controlling the pump. A method for rejecting heat from equipment using endothermic isomerization includes providing a compound capable of endothermic isomerization and transferring heat from a process fluid to the compound, such that the compound endothermically isomerizes to a higher energy level isomer.

Abstract: Disclosed is a device for generating a volume of gas from solid and liquid generates. In one particular embodiment, a volume of nitrogen gas is generated by combining the output of Sodium Azide and liquid nitrogen. A vacuum is initially maintained about the liquid nitrogen container by way of a dewar jacket. The present disclosure also relates to a method of manufacturing the disclosed gas generating device.

Abstract: Superior hydroxyls are provided which have effects on organic and inorganic compounds and/or pollutants over substantial periods of time and/or at substantial distances from where the superior hydroxyls are generated. Also provided is a hydroxyl generator, in which UV-lamps are positioned such that the coronas which they produce when emitting UV-radiation fill substantially all of the interior space of the hydroxyl generator. The coronas overlap each other by a maximum amount of between 5% and 25% of the radius of each corona.

Abstract: A wall socket aroma diffuser using an aroma capsule is provided, including a wall socket aroma diffuser having a transparent receiving unit and an aroma capsule received in the wall socket aroma diffuser. The aroma capsule is heated to diffuse scent, and is disposable after the aroma thereof is diffused into an ambient environment completely. It is thus easy, safe for a user to replace the used aroma capsule with a new one because the aroma capsule will not be broken and the aroma thereof will not flow to a region outside of the aroma capsule. The user does not need to wash the aroma diffuser. The wall socket aroma diffuser further includes a light emitting diode that emits and projects light onto the transparent receiving unit. The light is guided and diffused by the receiving unit to generate color that pleases people's eyes.

Abstract: A multiple scent delivery device includes a support housing having a plurality of holes therein and having an upper end and a lower end, a heating source removably connected to a lower end of said upwardly disposed support housing, a cone shaped inner flue operably disposed within the support housing having a plurality of holes therein and having an upper end and a lower end and an upper container removably disposed on the upper end of support housing in spaced-apart relationship above from the heating source for retaining an aromatic substance, whereby heat generated induces the retained aromatic substance within the upper container to disperse into the ambient air.

Abstract: In one embodiment, the invention is to a dry reagent composition configured as a solute to be dissolved into whole-blood prior to a whole-blood immunoassay, the dry reagent composition comprising: goat IgG, mouse IgG, dextran, a buffer, proclin, and sodium chloride in a support matrix. In another embodiment, the invention is to a dry reagent composition configured as a solute to be dissolved into whole-blood prior to a whole-blood immunoassay, the dry reagent composition comprising dextran and a salt in a support matrix.

Abstract: The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are a microfluidic valve suitable for use in isolating a PCR chamber in a microfluidic substrate, and a method of making such a valve.

Abstract: Multiplex binding assay assemblies are disclosed. The assemblies generally include at least one assay bar that includes a top side, a bottom side, and at least one well accessible from the top side of the assay bar. Each well includes a side surface, a bottom surface, an open top end, and at least one secondary container, with each secondary container including a capillary tube that (i) begins at a location within an interior volume of the well and (ii) ends at a location beneath the bottom surface of the assay bar. The assemblies further include a dispenser bar that is adapted to be positioned adjacent to the top side of the assay bar, which includes one or more reservoirs that are configured to provide one or more reagents to the at least one secondary container located in each well of the assay bar.

Abstract: There is provided a biochip stamping device. The biochip stamping device includes a stamping jig in which a first biochip is aligned; an inverting mechanism vertically inverting a second biochip; and a movement mechanism transferring the vertically inverted second biochip on the stamping jig to combine the first biochip and the second biochip.

Abstract: A dispensing apparatus includes: a dish mounting portion having a mounting surface mounted with a dish having a bottom surface and a side surface surrounding the bottom surface; a syringe, arranged above the dish mounting portion, having a nozzle configured to discharge liquid toward an interior of the dish; and a first driving portion configured to change the syringe in direction with respect to a first axis as a center, wherein the first axis is orthogonal to a normal to the mounting surface of the dish mounting portion.

Abstract: A tester for testing for explosives comprising a body, a lateral flow swab unit operably connected to the body, a explosives detecting reagent contained in the body, and a dispenser operatively connected to the body and the lateral flow swab unit. The dispenser selectively allows the explosives detecting reagent to be delivered to the lateral flow swab unit.

Abstract: The present invention relates to a micro-channel reactor for producing synthetic natural gas, and more particularly, to a micro-channel reactor for producing synthetic natural gas containing methane gas from synthetic gas, including a porous nickel plate catalyst part.

Abstract: Processes for using a combination of carbon dioxide and oxygen in the dehydrogenation of hydrocarbons are provided. A hydrocarbon feedstock, carbon dioxide and oxygen are fed to an oxidative dehydrogenation reactor system containing one or more catalysts that promote dehydrogenation of the hydrocarbon feedstock to produce a dehydrogenated hydrocarbon product. The processes of the present invention may be used, for example, to produce styrene monomer by dehydrogenation of ethylbenzene using carbon dioxide and oxygen as oxidants.

Abstract: This invention provides novel compositions comprising substituted polyamines as acid gas scrubbing solutions and methods of using the compositions in an industrial system. The invention relates to the use of such polyamine compounds in industrial processes to remove acidic contaminants from natural and industrial fluid streams, such as natural gas, combustion gas, natural gas, synthesis gas, biogas, and other industrial fluid streams. The compositions and methods of the invention are useful for removal, absorption, or sequestration of acidic contaminants and sulfide contaminants including CO2, H2S, RSH, CS2, COS, and SO.

Abstract: Several embodiments of high-efficiency catalytic converters and associated systems and methods are disclosed. In one embodiment, a catalytic converter for treating a flow of exhaust gas comprising a reaction chamber, a heating enclosure enclosing at least a portion of the reaction chamber, and an optional coolant channel encasing the heating enclosure. The reaction chamber can have a first end section through which the exhaust gas flows into the reaction chamber and a second end section from which the exhaust gas exits the reaction chamber. The heating enclosure is configured to contain heated gas along the exterior of the reaction chamber, and the optional coolant channel is configured to contain a flow of coolant around the heating enclosure. The catalytic converter can further include a catalytic element in the reaction chamber.

Abstract: Aspects of the invention relate to a base metal catalyst composition effective to catalyze the abatement of hydrocarbons, carbon monoxide and nitrogen oxides under both rich and lean engine operating conditions comprising a support including at least 10% by weight of reducible ceria doped with up to about 60% by weight of one or more of oxides selected from the group Al, Pr, Sm, Zr, Y, Si, Ti and La; and a base metal oxide on the reducible ceria support, the base metal selected from one or more of Ni, Fe, Mn, Cu, Co, Ba, Mg, Ga, Ca, Sr, V, W, Bi and Mo, the base metal catalyst composition effective to promote a steam reforming reaction of hydrocarbons and a water gas shift reaction to provide H2 as a reductant to abate NOx. Other aspects of the invention relate to methods of using and making such catalysts.

Abstract: A process for removal of H2S and CO2 from an acid gas stream comprising H2S and CO2, the process comprising the steps of: (a) reacting H2S in the acid gas stream with SO2 to form sulphur vapor and water vapor, thereby obtaining a first off-gas stream comprising CO2, water vapor, sulphur vapor, residual SO2 and residual H2S; (b) converting residual SO2 in the first off-gas stream to H2S in a first off-gas treating reactor, thereby obtaining a second off-gas stream depleted in SO2 and enriched in H2S and CO2 compared to the first off-gas stream; (c) contacting the second off-gas stream with an H2S absorbing liquid, thereby transferring H2S from the gas stream to the H2S absorbing liquid to obtain H2S absorbing liquid enriched in H2S and a third off-gas stream enriched in CO2; (d) removing CO2 from the third off-gas stream by contacting the third off-gas stream with CO2 absorbing liquid in a CO2 absorber, thereby transferring CO2 from the third off-gas stream to the CO2 absorbing liquid to obtain CO2 absorbing l

Abstract: A reforming method of a metallurgical furnace generated exhaust gas includes reforming a high temperature exhaust gas discharged from a metallurgical furnace by adding a reducing agent to the gas, wherein addition of the reducing agent is initiated when an oxygen concentration in the exhaust gas is 1 vol % or less, and a reforming reaction is completed when a temperature of the exhaust gas is 800° C. or higher, and an apparatus thereof. The reducing agent is blown from a reducing agent blowing nozzle having a double pipe structure.

Abstract: The degradation of an absorbent solution comprising organic compounds having a amine function in aqueous solution is substantially reduced in the presence of a small amount of thiadiazole-derived degradation inhibiting agents defined by the general formula as follows: The absorbent solution is used to deacidize a gaseous effluent.

Abstract: A process for reducing nitrogen oxides and halogenated organic compounds in an incineration plant having at least one combustion chamber. The process comprises separating out fly ash using a dust collector. Water is added to and hydrochloric acid separated out in a first acid-operated scrubber. Water and ammonia are added so as to separate out sulphur dioxide in a second neutral or slightly acid-operated scrubber so as to form ammonium sulphite, a portion of the ammonium sulphite thereby reacts with oxygen so as to form an aqueous ammonium sulphate/ammonium sulphite solution. The aqueous ammonium sulphate/ammonium sulphite solution is introduced into an oxygen-containing smoke gas downstream of a secondary gas introduction area so as to decompose the ammonium sulphate and ammonium sulphite so as to form ammonia and sulphur dioxide.

Abstract: A method of preparing a trihalosilane comprising the separate and consecutive steps of (i) contacting a copper catalyst with hydrogen gas and a silicon tetrahalide at a temperature of from 500 to 1400° C. to form a silicon-containing copper catalyst comprising at least 0.1% (w/w) of silicon, wherein the copper catalyst comprises a metal selected from copper and a mixture comprising copper and at least one element selected from gold, magnesium, and platinum; and (ii) contacting the silicon-containing copper catalyst with a hydrogen halide at a temperature of from 100 to 600° C. to form a trihalosilane.

Abstract: This invention relates to a method for the manufacture of monolithic ingot of silicon carbide comprising: i) introducing a mixture comprising polysilicon metal chips and carbon powder into a cylindrical reaction cell having a lid; ii) sealing the cylindrical reaction cell of i); iii) introducing the cylindrical reaction cell of ii) into a vacuum furnace; iv) evacuating the furnace of iii); v) filling the furnace of iv) with a gas mixture which is substantially inert gas to near atmospheric pressure; vi) heating the cylindrical reaction cell in the furnace of v) to a temperature of from 1600 to 2500° C.; vii) reducing the pressure in the cylindrical reaction cell of vi) to less than 50 torr but not less than 0.05 torr; and viii) allowing for substantial sublimation and condensation of the vapors on the inside of the lid of the cylindrical reaction cell of vii).

Abstract: A non-stoichiometric perovskite oxide having the general chemical formula LaXMnOY, in which the molar ratio of lanthanum to manganese (“X”) ranges from 0.85 to 0.95, can be used in particle form as an oxidation catalyst to oxidize NO to NO2 in an exhaust aftertreatment system for a hydrocarbon-fueled engine. The oxygen content (“Y”) fluctuates with variations in the molar ratio of lanthanum to manganese but generally falls somewhere in the range of 3.0 to 3.30. The crystal lattice adjustments spurred by the non-stoichiometric molar ratio of lanthanum to manganese are believed responsible for an enhanced NO oxidative activity relative to similar perovskite oxides with a higher molar ratio of lanthanum and manganese.

Abstract: An object is to provide an expanded graphite sheet at the use stage that can prevent can prevent degradation in product quality and deterioration in product yield by inhibiting the expanded graphite sheet from containing impurities even when the expanded graphite sheet is actually used. An expanded graphite sheet at the use stage in a condition in which the expanded graphite sheet is packed with a packing material and thereafter removed from the packing material, characterized in that all of the amounts of Al, B, Be, Ca, Cu, Fe, Li, Mg, Ni, S, Ti, V, and Zn as determined by an ICP emission spectroscopy method, the amounts of K and Na as determined by an atomic absorption spectrometry method, and the amount of Si as determined by an absorption spectrophotometry method are at a level less than the detection limit.

Abstract: The present invention relates to a mesoporous titania bead and the preparation method thereof, wherein said mesoporous titania bead has a diameter of 200-1000 nm, specific surface area of 50-100 m2/g, porosity of 40-60%, pore radius of 5-20 nm, pore volume of 0.20-0.30 cm3/g, and the titania comprised in the bead is anatase titania.

Abstract: One aspect of the present invention relates to mesostructured zeolites. The invention also relates to a method of preparing mesostructured zeolites, as well as using them as cracking catalysts for organic compounds and degradation catalysts for polymers.

Abstract: The invention relates to a method for diagnosing a kidney disease state. The method comprises the steps of administering to a patient a composition comprising a conjugate or complex of the general formula V-L-D where the group V comprises a vitamin receptor binding ligand that binds to kidney proximal tubule cells and the group D comprises a diagnostic marker, and diagnosing the kidney disease state. The invention also relates to a method for treating a kidney disease state. The method comprises the steps of administering to a patient suffering from the disease state an effective amount of a composition comprising a conjugate or complex of the general formula V-L-D where the group V comprises a vitamin receptor binding ligand that binds to kidney proximal tubule cells and the group D comprises an antigen, a cytotoxin, or a cell growth inhibitor, and eliminating the disease state.

Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.

Abstract: A composition of matter comprising an amphiphilic star polymer, the star polymer comprising a crosslinked microgel core and 6 or more independent polymer arms covalently linked to the core, the 6 or more arms each comprising a hydrophilic polymer chain segment and a hydrophobic polymer chain segment; wherein each individual metal selected from the group consisting of beryllium, magnesium, calcium, strontium, barium, radium, aluminum, gallium, indium, thallium, germanium, tin, lead, arsenic, antimony, bismuth, tellurium, polonium, and metals of Groups 3 to 12 of the Periodic Table has a concentration in the star polymer of greater than or equal to 0 parts per million and less than or equal to 100 parts per million.

Abstract: In magnetic resonance imaging (MRI), selected magnetic dipoles in a subject are aligned with a main magnetic field for later manipulation, and signals received after such manipulations are used to create image representations of the subject. One drawback is that even powerful magnetic fields can only align a very small percentage of dipoles in the region of the field. Electromagnetic radiation endowed with orbital angular momentum (OAM) aligns dipoles along the direction of travel of the radiation, but at a much higher percentage; as high as 100% of the dipoles in the region can be aligned. Resultantly, resonance signals emanating from the region are several orders of magnitude stronger than signals emanated using traditional MRI techniques. All electromagnetic radiation, including visible light can be endowed with OAM and used to hyperpolarize a region of interest.

Abstract: A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administerable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of additional pH adjusting substance in combination with the effervescent for promoting the absorption of drugs is also disclosed.

Abstract: The present invention relates to a fluid composition intended for protecting the skin and/or hair against ultraviolet radiation, characterized by the fact that it comprises, in a cosmetically acceptable aqueous support, at least: (a) one photoprotective system capable of screening out UV radiation; and (b) one 2-alkoxy-4-alkyl ketone phenol compound. The present invention also relates to the use of a 2-alkoxy-4-alkyl ketone phenol compound in a composition comprising, in a cosmetically acceptable medium, at least one photoprotective system capable of screening out UV radiation.

Abstract: A base coat nail enamel composition that forms a decorative color effect over natural or synthetic nails. The base coat nail enamel composition includes at least one dye in a sufficient amount, such that when a clear, tinted or pigmented top coat nail enamel composition is formed thereon, the combined base and top coat nail enamel compositions will exhibit a decorative effect by virtue of forming a different color than either the color of the base nail enamel composition or the top coat nail enamel composition.

Abstract: The present invention is directed to a cosmetic composition comprising an effect pigment based on a glass flake as a substrate with a coating, said coating comprising at least one layer of at least one high refractive material, said material having a refractive index of at least 1.8, and/or a semitransparent metal coating wherein said glass flakes comprising the following composition: 65-75 wt.-% silicon oxide, preferably SiO2 2-9 wt.-% aluminium oxide, preferably Al2O3 0.0-5 wt.-% calcium oxide, preferably CaO 5-12 wt.-% sodium oxide, preferably Na2O 8-15 wt.-% boron oxide, preferably B2O3 0.1-5 wt.-% titanium oxide, preferably TiO2 0.0-5 wt.-% zirconium oxide, preferably ZrO2 based on the weight of said glass flakes. The invention is also directed to the use of the cosmetic composition.

Abstract: A deodorizing composition containing: (a) from about 10 to 30% by weight of a dialkyl carbonate corresponding to formula I: wherein R1 is a linear alkyl and/or alkenyl group containing from about 6 to 22 carbon atoms, a 2-ethylhexyl, an isotridecyl, an isostearyl group or a group derived from a polyol containing 2 to 15 carbon atoms and at least two hydroxyl groups; R2 has the same meaning as R1 or is an alkyl group containing from about 1 to 5 carbon atoms; and n and m, independently of one another, represent a number up to 100, and (b) an antiperspirant.

Abstract: Human sebum mimetics and methods for producing human sebum mimetics are provided. In one exemplary embodiment, a human sebum mimetic comprises a wax ester derived from interesterification of refined botanical oil comprising palmitoleic acid and refined jojoba oil, a phytosterol, and phytosqualene. A method for producing a human sebum mimetic comprises mixing refined macadamia oil and refined jojoba oil, interesterifying the refined macadamia oil and the refined jojoba oil, adding a phytosterol alter the interesterifying, and adding phytosqualene after the interesterifying.

Abstract: Human sebum mimetics and methods for producing human sebum mimetics are provided. In one exemplary embodiment, a human sebum mimetic comprises a wax ester derived from interesterification of refined botanical oil comprising palmitoleic acid and refined jojoba oil, a phytosterol, phytosqualene, and/or phytosteryl macadamiate. Method for producing a human sebum mimetic comprises mixing refined macadamia oil and refined jojoba oil, interesterifying the refined macadamia oil and the refined jojoba oil, adding a phytosterol, adding phytosteryl macadamiate, and adding phytosqualene after the interesterifying.

Abstract: The invention relates to a process for straightening keratin fibers, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibers, (ii) a step in which the temperature of the keratin fibers is raised, using a heating means, to a temperature of between 110 and 250° C.

Abstract: The present disclosure relates to a cosmetic composition for keratin fibers, for example, human keratin fibers such as hair, comprising: at least one anionic surfactant (A) comprising, in its structure, at least one group chosen from sulphate, sulphonate, and phosphate groups; at least one carboxylic anionic surfactant (B) other than the at least one anionic surfactant (A); at least one surfactant (C) chosen from amphoteric and zwitterionic surfactants; at least one alkyl(poly)glycoside non-ionic surfactant (D); at least one cationic polymer (E); at least one zinc salt (F); and optionally at least one UV-screening agent (G); and further wherein the weight ratio of the total amount of the surfactants (A), (B), (C), and (D) to the amount of zinc element of the at least one zinc salt has a value of less than 30.

Abstract: A cosmetic comprising an amino acid oil gelling agent, a polyamide resin and a monoester, wherein the amino acid oil gelling agent is one or more selected from dibutyl ethylhexanoyl glutamide and dibutyl lauroyl glutamide, and wherein said monoester is one or more selected from a monoester having a C9 to C24 linear chain or branched chain fatty acid moiety and/or a C9 to C24 linear chain or branched chain alcohol moiety, and said monoester is 20-80 mass % of the cosmetic. Cosmetic products, and methods for making and preparing cosmetics.

Abstract: A composition comprising: at least one alkoxysilane having at least one solubilizing functional group and at least one amino substituent; at least one glycosaminoglycan chosen from hyaluronic acid; water; optionally, at least one auxiliary ingredient; and optionally, at least one volatile solvent.

Abstract: The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.

Abstract: The invention relates to materials comprising siloxanes, preferably the materials have thermal-responsive properties. In some embodiments, the invention relates to silsesquioxane groups functionalized with polymers. In another embodiment, silsequioxane-polymer conjugates comprise polylactone segments. The silsequioxane-polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices. In further embodiments, the invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement.

Abstract: A comb-like surfactant polymer for changing the surface properties of biomaterials is described. The surfactant polymer comprises a polymeric backbone of repeating monomeric units having functional groups for chemically attaching to side chains, a plurality of hydrophobic side chains attached to the backbone via the functional groups and a plurality of hydrophilic side chains chemically attached via functional groups to the polymeric backbone. The hydrophilic side chains providing anti-thrombogenic properties to the surfactant. An antimicrobial agent selectively attached to some hydrophilic side chains thereby providing additional antimicrobial properties to the surfactant. The surfactant polymer may be applied to the surface of medical devices to reduce the surfaces thrombogenicity and decrease the number of microorganisms on the surface.

Abstract: The invention relates to a polymer-micelle complex. The polymer-micelle complexes include a negatively charged micelle that is electrostatically bound to a water-soluble polymer bearing a positive charge. The polymer does not comprise block copolymer, latex particles, polymer nanoparticles, cross-linked polymers, silicone copolymer, fluorosurfactant, or amphoteric copolymer. The compositions do not form a coacervate, and do not form a film when applied to a surface.

Abstract: Providing a new method of treating inflammatory gastrointestinal disorders and a food product for the prevention or improvement of inflammatory gastrointestinal disorders. Prevention or treatment of inflammatory gastrointestinal disorders is possible by oral administration of recombinant IL-10 expressed in rice plant seeds.

Abstract: An apparatus and method for administering focused energy to a body using either a single energy applicator or multiple energy applicators to supply heat prior to, concurrently with and/or after delivery of a drug, gene and/or viral vector. A multi-modality treatment using a localized, focused and/or regional heating apparatus, which supplies heat to a defined area of a patient's body. The apparatus is used heat is used to pretreat a specific body site, to activate thermoactivated drugs, genes, or viral vectors, and/or to deliver drugs, genes, or viral vectors to the specific body site. The heating apparatus is provided with one or more variable and adjustable probes and one or more delivery ports heat the specific treatment site and to deliver the thermoactivated drugs and genes to the specific treatment site. Each probe may optionally be provided with one or more temperature sensors to allow for the temperature in the specific treatment site and the surrounding tissue to be properly regulated.

Abstract: The present invention relates to the generation of vascularized human heart tissue from human primordial Islet1-positive (ISL1+) progenitors, and more particularly the generation of vascularized human heart tissue from human primordial Islet1+ cardiovascular stem cells which are positive for markers ISL1+/NKX2.5?/KDR?. One aspect of the invention relates to isolation of human ISL1+ primordial cells from human pluripotent cells, such as human ES cells or other human pluripotent stem cell sources, wherein the human ISL1+ primordial cells can differentiate into three different lineages; cardiomyocyte lineages, endothelial lineages and smooth muscle lineages. Another aspect relates to use and implantation of the human primordial ISL1+ progenitors into an animal model to generate human vascularized heart tissue, and more particularly, the production of an in vivo humanized model of vascular disease.

Abstract: The present invention relates to a novel wild-type Lactococcus lactis subsp. cremoris bacteria strain with increased vitamin K2 production and mutants and variants thereof and methods for preparation of a fermented food or feed product enriched in vitamin K2 and a vitamin K enriched edible product for amelioration and/or prevention of vitamin K deficiency. The present invention also relates to the fermented food or feed product and the edible product obtainable by the methods herein and to the wild-type Lactococcus lactis subsp. cremoris bacteria strain for use in treatment and/or prevention of vitamin K deficiency in a mammal, such as a human.