Abstract: Orthopedic fastener devices for fixation of fractured bones are disclosed. The orthopedic fastener device is in the form of an orthopedic fastener having an IM nail coated on its external surface with a bioabsorbable or biodegradable hydrogel. Also disclosed are hydrogel coated orthopedic fastener devices in the form of a K-wire or bone screw, a method for stabilizing a fractured long bone fracture by inserting an orthopedic fastener into the medullary canal of the bone and a kit for fastener implantation.

Abstract: System, including methods, apparatus, and kits, for bone fixation using a fixation device including a mounting portion and a fastener that attaches to the mounting portion. In some embodiments, the fixation device may include first and second mounting portions configured to be disposed across a bone from each other and secured with a fastener that extends from one of the mounting portions, through the bone, and to the other mounting portion. The system also may include a tool to facilitate installation of the fixation device.

Abstract: A system for preparing a bone for receiving an articulating member is provided. The system includes a superior inferior component, a connection feature, a housing, at least one rotating member and a cutter. The superior inferior component is engaged to a structure. The connection feature is engaged with the superior inferior component. The housing is engaged with the connection feature. The rotating member is configured to rotate within the housing. The first cutter is engaged with the rotating member such that the rotation of the rotating member translates into rotation of the first cutter, wherein the first cutter rotates about an axis that is generally parallel to a natural surface of the bone.

Abstract: A system for anterior cruciate ligament (ACL) reconstruction using holes in bone created by retrograde cutting. A rotary cutter, mounted onto an insertion post of a tibial guide, is inserted through an anteromedial portal and the rotary cutter placed on the anatomical origin of an ACL tibial insertion. A drill pin is drilled through the tibia and advanced until it contacts and engages a cannulation in the rotary cutter on the guide. Further rotation of the drill pin disengages the rotary cutter from the guide. The retrograde drill pin is then retracted and simultaneously rotated for retrograde cutting of a socket or tunnel of desired depth in the tibia. A similar system is provided to form a socket or tunnel in the femur except that a femur guide is used in place of the tibial guide.

Abstract: A drill and drill cover and autogenous bone collector using the same are provided. The autogenous bone collector comprises s shaft unit connected to a driving device and a cutting unit which revolves and collects bone paticles of a patient. The cross-sectional area of the cutting unit is from 10% to 40% of an area of an imaginary circle having a radius corresponding to a distance from the center of the cutting unit to the outermost end portion of the cutting unit.

Abstract: A surgical sagittal saw for use with a complementary blade assembly that includes a static bar. The saw includes a head over which the blade assembly bar is seated. A clamp rod is able to mounted to the head to move along the longitudinal axis of the rod. The rod has a head that, as result of the longitudinal movement of the rod is moved towards and away from the head. A blade assembly is disposed on the saw head adjacent the rod. The rod can be positioned in a run state so that the rod head abuts the bar of the blade assembly so as to hold the blade assembly to the saw head. Alternatively, the rod can be repositioned in a load state the rod head is spaced from the saw head. This allows the blade assembly to be removed and replaced. A control member mounted to the saw head controls the movement of the rod. When the rod is moved from the load state to the run state, a biasing member places a force on the rod to hold the rod in the run state.

Abstract: The present disclosure relates to systems and methods for preparing a distal end of a femur for receiving a knee prosthesis. A method can include installing a valgus guide onto an intermedullary rod, coupling a drill guide with said valgus guide, resting a boom tip of said drill guide on a high part of the femur, drilling a hole into a distal portion of a medial condyle using a first drill hole of said drill guide and drilling a hole into a distal portion of a lateral condyle using a second drill hole of said drill guide, and, subsequent to drilling the first and second drill holes, resecting the distal portion of the medial condyle of the femur and the distal portion of the lateral condyle of the femur. A system can include a valgus guide, a drill guide, and a resection tower, among other things.

Abstract: An instrument assembly for resecting a distal femur for receipt of a knee implant, comprising an intramedullary rod and resection instruments. A valgus portion of the intramedullary rod has series of engagement members positioned to provide a plurality of engagement positions for use in fixing the resection instruments on the valgus portion. The resection instruments are configured to selectively engage and selectively lock on the valgus rod at the engagement positions via the engagement members. The engagement members preferably comprise pairs of substantially vertical indents arranged in parallel along opposing sides of said valgus portions. The resection instruments preferably engages and locks to said engagement members via a sliding rod engagement member. The resection instruments preferably include a distal cut guide having a distal resection slot and a femoral resection block.

Abstract: A bone filling device includes a catheter that defines a longitudinal axis and extends between a proximal end and a distal end. A first lumen extends along the longitudinal axis of the catheter and defines a first passageway. A second lumen extends along the longitudinal axis of the catheter and defines a second passageway. An inflatable body includes a wall that defines a fillable cavity. The fillable cavity is in fluid communication with the first passageway. A bone filler delivery port continuous with the second passageway and configured to dispense bone filling material.

Abstract: A fenestrated bone screw and method of use is disclosed in which a bone cement injection tube may be readily and sealably connected to the head of the bone screw by means of a bayonet connector so that bone cement from a cement pump may be forced into a cannula of the bone screw and into the bone structure proximate the fenestrations of the bone screw. Upon completion of the injection of the bone cement, the cement tube may be readily disconnected from the bone screw in such manner that leakage of bone cement is minimized. A surgical method of injecting bone cement into bone structure using such a cannulated, fenestrated bone screw is also disclosed.

Abstract: Methods, apparatus, compositions for reinforcing bone structures are disclosed as well as a reinforced bone structure itself. By injecting a low viscosity polymeric solution into a trabecular bone region at least partly surrounded by cortical bone allowing it to cross-link in-situ, a non-degradable gel can effectively reinforce the region by retaining fluid in the constrained space within the cortical shell. Due to the low viscosity of the pre-cross-linked aqueous polymeric solution, the entire site could be filled effectively and consistently. Additionally, by injecting a low viscosity pre-cursor, the solution fills the natural intra-trabecular spaces without substantial alteration of the trabecular structure at the site.

Abstract: A hinged pivoting guide for positioning a femoral tunnel in anterior cruciate ligament (ACL) reconstruction locates a drilling hole for placement that optimally penetrates a minimal depth of soft tissue (skin, muscle, etc.) yet directs drilling into a sufficiently rigid and structurally sound area of the femur. The hinged guide allows placement of an aimer point at a desired drilling exit location on the femur. The hinge is adapted to secure the aimer at a degree of rotation about an axis defined by the hinge rotation, such that the axis passes through the aimer point throughout rotation of the hinge while maintaining the aimer point in line with an insertion guide slideably movable through the aperture in the handle, the aperture defined by an insertion axis extending toward the aimer point such that the aimer point remains disposed at the intersection of the hinge axis and the insertion axis.

Abstract: Improved methods and apparatuses for inserting pedicle screws in accordance with embodiments of the present invention include an image correction algorithm. In various embodiments, an original image of a region of interest of a patient including a pedicle is created with an X-ray emitter and an X-ray detector. Due to the X-ray emitter not being aligned orthogonal to the X-ray detector, the original image will be skewed. Using a known location and orientation of the X-ray detector, a location and orientation of the X-ray emitter provided by a position monitoring system, and the original image, a processing system can execute the image correction algorithm to provide a corrected image to allow a surgeon to properly insert a pedicle screw along the axis of the pedicle while viewing an accurate corrected image in real time.

Abstract: There is provided an intraocular lens insertion device capable of appropriately regulating the motion of a rear supporting portion during a process of moving an intraocular lens, and reducing the possibility of reoperation being required after the intraocular lens is inserted into an eye. An intraocular lens insertion device 1 comprises a main body 2, and a slider 3 and a plunger 4 that are attached to the main body 2. Further, the intraocular lens insertion device 1 is of a preset type in which an intraocular lens 5 is placed inside the main body 2 in advance. The slider 3 includes a first abutting portion 21 for pushing up a supporting portion 7 (rear supporting portion 7a) arranged on a rear side of an optical part 6 with respect to a lens advancement axis A, and second abutting portions 22a, 22b abutting against an outer edge of a rear portion of the optical part 6.

Abstract: Systems and methods for treating a patient having a head with a first ear and a second ear, function by aligning a first device with a tympanic membrane of the first ear; inputting a command to an input device operatively coupled to the first device to generate a signal; and actuating the first device in response to the signal so as to drive a penetrator of the device through the tympanic membrane.

Abstract: A marker delivery device is configured for deploying a tissue marker. The marker delivery device includes a handle having a chamber, and a cannula. According to one aspect, the cannula has a flexible portion formed by a slot arrangement having of a plurality of spaced-apart substantially parallel peripheral slots extending through the side wall of the cannula to the lumen. A marker introducer rod is movably disposed in the lumen of the cannula for deploying the mark, and has a flexible region that corresponds to the flexible portion of the cannula. According to another aspect, a retraction mechanism is mounted to the handle and is configured to facilitate a complete retraction of both the cannula and the marker introducer rod into the chamber of the housing of the handle upon an actuation of the retraction mechanism.

Abstract: The present invention relates to a convenient, minimally invasive surgical instrument, and more particularly to a minimally invasive surgical instrument to allow a user to operate an end effector by manipulating a handling unit or the like to perform a minimally invasive surgery in a delicate and convenient manner. According to one aspect of the invention, there is provided a minimally invasive surgical instrument comprising: a shaft; an end effector being connected to one end of the shaft via a joint unit; a rotation manipulation unit being connected to to the other end of the shaft, the rotation manipulation unit comprising a gyro link including a gyro wheel; and a plurality of wires being connected between the joint unit and the gyro wheel, wherein the end effector carries out joint motion by the joint unit according to the action of at least some of the plurality of wires caused by a manipulation of the gyro wheel.

Abstract: Mechanisms, assemblies, systems, tools, and methods incorporating the use of an offset drive shaft within an independently rotating member are provided. An example mechanism includes a base and a main shaft mounted to rotate relative to the base, a first drive shaft mounted inside the main shaft, and a first drive feature engaged with the first drive shaft. The main shaft includes a proximal end, a distal end, and a main shaft rotational axis defined therebetween. The first drive shaft is offset from the main shaft rotational axis. A first drive feature rotational axis is defined for the first drive feature and is fixed relative to the base as the main shaft rotates. The first drive feature rotates the first drive shaft.

Abstract: A surgical apparatus includes a cannula and a surgical instrument. The cannula includes a curved longitudinal axis along at least a portion of its length. The surgical instrument includes an elongated shaft having a distal end and a proximal end, and an end effector coupled to the distal end of the elongated shaft. At least a portion of the end effector is configured to contact an inner surface of the cannula during insertion of the surgical instrument into the curved cannula. A threshold galling stress between the portion of the end effector and an inner surface of the curved cannula is at least 10,000 pounds per square inch.

Abstract: Surgical controlling systems and methods. A surgical controlling system includes: at least one surgical tool adapted to be inserted into a surgical environment of a human body for assisting a surgical procedure; at least one location estimating unit to real-time locate the 3D spatial position of at least one surgical tool at any given time t; and at least one movement detection unit in communication with a movement's database and with the location estimating means. The system also includes a controller having a processing unit in communication with a controller's database. The controller controls the spatial position of at least one surgical tool.

Abstract: An input device for a robotic medical system includes a handle configured to be rotatable about a center axis, and to be longitudinally displaceable along the center axis. The input device also includes a deflection control element disposed on the handle and configured to selectively control deflection of the distal end of a flexible medical instrument electrically coupled to the input device. Longitudinal displacement of the handle may cause or result in a corresponding longitudinal motion or deflection of the flexible medical instrument. Rotation of the handle may cause or result in a corresponding rotation of the deflection plane. Longitudinal displacement and rotation of the handle may be detected or sensed electronically.

Abstract: An apparatus for maintaining a robotic catheter system in a responsive state includes a catheter, a plurality of linear translatable control elements, and a controller. In an embodiment, the catheter includes a proximal portion, a distal portion, and at least two steering wires. The steering wires may be configured at one end to control the movement of at least a portion of the distal portion of the catheter and at the other end for connection to a control member. In an embodiment, each control element may be configured to engage or interface with a respective control member, and the controller may be configured to measure a force exerted on at least one control member by a respective control element and further configured to linearly translate the control element to substantially maintain a force within a predetermined range.

Abstract: An articulated surgical instrument for enhancing the performance of minimally invasive surgical procedures. The instrument has a high degree of dexterity, low friction, low inertia and good force reflection. A unique cable and pulley drive system operates to reduce friction and enhance force reflection. A unique wrist mechanism operates to enhance surgical dexterity compared to standard laparoscopic instruments. The system is optimized to reduce the number of actuators required and thus produce a fully functional articulated surgical instrument of minimum size.

Abstract: A skin cleanser includes a surface, such as a silicone surface, with at least one textured portion for transmitting vibrational tapping to the skin. The skin cleanser includes at least one oscillating motor for generating the tapping motion to the skin. The textured portion includes touch-points or a wave that transmit the tapping motion to skin in contact with the textured portions. The touch-points may include thicker and thinner formations of the touch-points to provide firmer or softer vibrations to the skin. The touch-points are within about 0.5 to 2.5 mm in diameter. One configuration includes multiple oscillating motors configured to provide different vibration frequencies at around 50-300 Hertz and operable simultaneously.

Abstract: An assembly is provided to facilitate the deployment of at least one fastener through tissue, such as stomach tissue. The assembly comprises a fastener deploying device arranged to deploy a fastener through the tissue and a snare arranged to bind the tissue and fastener deploying device together as the fastener deploying device deploys a fastener through the tissue.

Abstract: Systems and methods introduce and deploy prosthesis into a blood vessel or hollow body organ by intra-vascular access. The prosthesis is secured in place by fasteners which are implanted by an applier that is also deployed by intra-vascular access. The applier is configured to permit controlled, selective release of the fastener in a step that is independent of the step of implantation.

Abstract: A surgical clip applier is provided and includes a ratchet mechanism having a rack member connected to a drive channel such that axial translation of the drive channel results in axial translation of the rack member, the rack member defining a first set of teeth along a first side thereof and a second set of teeth along a second side thereof. The ratchet mechanism including a first pawl and a second pawl each tiltably supported in the housing and disposed on respective opposed sides of the rack member; and a buckling spring interposed between the first pawl and the second pawl and constrained in a slot formed in the rack member, wherein the buckling spring is dimensioned so as to bow in one of a proximal direction and a distal direction.

Abstract: A suture trimmer including an elongate shaft including an elongate lumen extending proximally from a distal end of the elongate shaft, a transverse through-opening disposed proximal the distal end of the shaft, and a groove extending proximally from the distal end of the shaft to a distal end of the opening. A fitting is disposed within the elongate lumen at the distal end of the shaft and extends distally therefrom. A cutting member is slidably received within the lumen of the shaft and configured to move between a proximal end of the opening and the distal end of the opening and cut a suture disposed within and extending from the opening.

Abstract: A medical device including an elongate member having a proximal end, a distal end, and a lumen extending therebetween. The medical device may further include an end-effector disposed at the distal end of the elongate member, the end-effector may include a first arm, the first arm may have a distal end, a proximal end, and an opening configured to receive a needle therein. The medical device may also include a second arm movably connected to the first arm and configured to alternate between a closed position and an open position relative to the first arm, wherein the second arm is movably connected to the first arm at a pivot point disposed at a location closer to the distal end of the second arm than the proximal end of the second arm.

Abstract: A suturing apparatus comprises a pair of jaws. A bendable needle housed in one of the jaws is adapted to carry a suture. A suture receiver is disposed adjacent to, or integral with, the opposite jaw to help disengage the suture carried by the bendable needle. A transition block curves the needle and directs it in a direction generally unparallel to an axis of the carrying jaw. The jaw housing the needle may include a lateral opening through which the suture may be inserted. The needle may also include a lateral notch which may be aligned with lateral opening to receive the suture. An actuator coupled to the needle enables the user to move the needle proximally to align the notch with the lateral slot.

Abstract: Embodiments may include fixation devices and methods for securing first and second body tissue portions. Fixation devices may include a base component, an insert component, and a flexible member. The base component may include a passage. The insert component may be positionable within at least a portion of the passage. The elongate member may be configured to be positioned through the first and second body tissue portions. The elongate member may be tensioned and pinched between the base component and insert component to secure the first and second portions.

Abstract: A surgical clip, in particular an aneurysm clip, includes two rotatably connected clip parts, each having a clamping arm, an operating arm, and an interposed annular section with an opening. A leg spring pretensions the two clip parts into an initial rotation position. The pivot bearing of the two clip parts is formed by a bearing sleeve and the winding body of the leg spring is arranged at least in part inside the bearing sleeve.

Abstract: A connector for joining a first hollow structure to the side wall of a second hollow structure, the connector comprising a first component comprising an inner collar; a hollow body; and a graft mounted to the inner collar and forming a conduit through the hollow body and the inner collar; and a second component comprising an outer collar and a hollow body, the hollow body of the second component being sized for coaxial disposition over the hollow body of the first component so that the outer collar of the second component can be adjustably positioned relative to the inner collar of the first component and so that the conduit of the graft provides fluid communication between (i) the region beyond the inner collar, and (ii) the region beyond the hollow body of the first component.

Abstract: Disclosed is a medical device for shaping a vessel accommodated therein in a predetermined form, wherein said vessel includes a vein and an artery which are connected at a artifactual vascular junction thereof. The device includes an external vascular support (100) having at least one vascular support wall for accommodating an exterior vessel wall of a vessel therein when implanted. The support includes an arterial portion (1304) for apposition with said artery when accommodated therein, and/or a venous portion (1302) for apposition with said vein when accommodated therein. The venous portion (1302) and/or said arterial portion (1304) are shaped at a junction thereof to provide a vessel rounding to at least a portion of said vessel junction when in apposition with the latter upon implantation of said device for said vessel shaping. Corresponding methods are also disclosed. Thus dysfunction or failure of a vessel of the artifactual vascular junction may be reduced, minimized, or eliminated.

Abstract: A device for intravascular intervention can comprise an intervention element, an elongate manipulation member, and a joining element. The elongate element can comprise a hooked portion extending about a proximal portion of the intervention element. The hooked portion can comprise a bend. The hooked portion can have (i) no substantial surface crack at an interior region of the bend and (ii) a maximum lateral dimension that is less than 0.027 inch. The joining element can substantially permanently attach the hooked portion to the intervention element.

Abstract: A catheter includes an elongate catheter body configured for insertion into a body lumen of a subject. A cutter is located generally at a distal end of the catheter body for rotation generally about a longitudinal axis of the cutter. An eccentric opening in a distal end portion of the cutter defines an angled cutting edge for cutting material from a wall of the body lumen. A center of the opening is offset from the longitudinal axis of the cutter. A cavity extends from the opening through the cutter from the distal end portion to a proximal end portion to allow material cut by the cutter to pass through the cutter into an interior passage of the catheter body for removal from the body lumen.

Abstract: A lumen reentry mechanism includes a catheter configured to bypass an area of stenosis, and having a longitudinal passage with a side hole. A piercing tool is positioned within the passage and has a transverse end section with a cutting tip, trapped between first and second longitudinally extending beads within the passage. Trapping of the piercing tool limits contact between the cutting tip and an inner surface of the catheter. Related methodology is also disclosed.

Abstract: A surgical instrument is provided that can comprise and end effector including two jaws and a cutting member configured to move between the jaws. In at least one embodiment, one or both of the jaws may be flexible, such that a jaw is configured to flex when gripping tissue. Further, at least one of the jaws may include a thin cross-sectional area such that the jaw flexes when gripping tissue. Additionally, in at least one embodiment, one or more compression elements may extend from the cutting member and may be configured to cause the jaws to close when the cutting member is advanced. The compression elements may comprise a roller and/or a low-friction material. Moreover, in at least one embodiment, one or both of the jaws may be precurved, away from the cutting member's longitudinal axis. Accordingly, in various embodiments, the overall force required to advance the cutting member and/or close the jaws may be reduced.

Abstract: Various embodiments are directed to a surgical instrument comprising, a shaft, and an end effector. The shaft may be coupled to the handle and may extend distally along a longitudinal axis. The end effector may be positioned at a distal end of the shaft and may comprise first and second jaw members and a reciprocating member. The first and second jaw members may define first and second longitudinal slots. The reciprocating member may be translatable distally and proximally parallel to the longitudinal axis and through the first and second longitudinal slots. A distal portion of the reciprocating member may define a blade.

Abstract: A surgical instrument (1) is provided with a rigid probe (2), and cuts off the trabecular meshwork by inserting this probe (2) into the canal of Schlemm. An inner tube portion having a cutter is equipped inside the probe, and the trabecular meshwork sucked in from a hole portion (22) is cut off by the cutter due to the movement of the inner tube portion. A protection portion (21) is formed on the tip the probe (2) and protects the outer wall of the canal of Schlemm when cutting the trabecular meshwork. According to the invention, an ophthalmic surgical instrument for glaucoma patients is provided, the surgical instrument having excellent operability and preventing cutting of parts that should not be cut off without fail.

Abstract: The present invention is directed toward an intragastric device used to treat obesity that includes a wire mesh structure capable of changing from a compressed pre-deployment shape to an expanded post-deployment shape with a greatly increased volume. The post-deployment shape contains a light weight at the top and a heavier weight at the bottom to ensure proper positioning within the stomach. In the post-deployment shape, the device contains larger spaces in the upper portion and smaller spaces in the lower portion to sequester food and delay gastric emptying. Alternatively, the device can be enveloped by a membrane containing larger holes at the top and smaller holes at the bottom to sequester food and delay gastric emptying. The device has a dynamic weight where the weight of the device in the pre-feeding stage is less than the weight of the device in feeding or post-feeding stage.

Abstract: A blood flow cessation device includes a catheter, an expandable member, and a rapid exchange port. The catheter includes a distal end portion and a proximal end portion. The expandable member is positioned at the distal end portion and is selectively expandable to stop blood flow through a vessel. The rapid exchange port is formed in the catheter at a location proximal of the expandable member. The rapid exchange port is configured receive a guidewire that passes through the distal end portion of the catheter to be positioned within the vessel.

Abstract: A device for intravascular intervention can comprise an intervention element, an elongate manipulation member, and a joining element. The elongate member can comprise a hooked portion extending about a proximal portion of the intervention element. The joining element can substantially permanently attach the hooked portion to the intervention element.

Abstract: A catheter device is disclosed for transvascular delivery of a medical device to a cardiac valve region of a patient. The catheter device comprises an elongate sheath (2) with releasable locking members for controllably locking the elongate sheath in a shape at least partly along its length from a relaxed state to a locked state when positioned in relation to a cardiac valve. Furthermore, alignment members (5) are provided to provide for a desired positioning in relation to the cardiac valve. Embolic protection (8) is further provided.

Abstract: A medical implantable occlusion device (100, 200) is disclosed comprising a fabric of at least one thread (101) and a structural formation (102) thereof having a collapsed and an expanded shape, the formation comprises a proximal and a distal portion (103, 104), a longitudinal axis (105) extending between the proximal and distal portion, wherein at least one of the proximal and distal portions comprises a peripheral edge (107, 108) having a first (109, 109?) and a second (110, 110?) radius of curvature in a direction substantially perpendicular to the longitudinal axis, wherein the first radius of curvature is different from the second radius of curvature.

Abstract: Methods are disclosed for converting on a mass scale elongated material webs into finished parts or devices. Slits form strands in a web, the strands comprising interconnected objects which correspond to parts of finished devices. Strands are combined with additional webs to form a material laminate from which finished devices are die cut. The methods are suitable for a range of converting applications including medical devices, particularly the external nasal dilator. Complex dilator devices produced from the methods are formed as a single body truss having horizontal regions adapted to engage outer wall tissues of first and second nasal passages of a nose. When in use the dilator stabilizes or expands nasal outer wall tissues and prevents the outer wall tissues from drawing inward during breathing. Methods of manufacture comprise separate steps for fabricating and assembling the elements and layers of finished dilator devices and for packaging finished devices individually or in groups.

Abstract: A powered surgical apparatus, which is configured to engage tissue includes a handle assembly having proximal and distal portions, a movable portion operatively connected to the distal portion of the handle assembly, a tool assembly operatively coupled to the movable portion, a power source configured to supply electrical power, and a transmission system operatively associated with the power source. The movable portion is movable with respect to the handle assembly. The tool assembly is adapted to engage tissue. The transmission system is configured to transmit electrical power or signals between the handle assembly and the movable portion.

Abstract: A tissue puncture closure device includes a vessel locator and a sealing plug delivery member. The vessel locator includes an expandable member. The sealing plug delivery member includes a carrier tube, a sealing plug, and a locking member. The carrier tube includes a distal end and a side opening, the side opening extending proximally from the distal end along at least a portion of a length of the carrier tube to provide lateral insertion of the vessel locator into an interior of the carrier tube. The sealing plug includes a lumen and a slot extending from a distal end to a proximal end of the sealing plug, wherein the slot provides lateral access of the vessel locator into the lumen. The locking member is operable to retain the vessel locator within the sealing plug delivery member.

Abstract: Various embodiments of methods for closing vascular holes and associated vascular closure devices are described herein. The methods, generally speaking, use hemostatic devices intended to stop bleeding by closing vascular access puncture sites following percutaneous diagnostic or therapeutic procedures. The methods may include positioning a sealing plug in the vascular hole. In one embodiment, the sealing plug may extend through the vascular hole into the vessel. The sealing plug may expand and thereby create a lip inside the vessel that holds the sealing plug in place.

Abstract: The present disclosure relates to a prosthesis comprising: -at least one flexible mesh delimited by a peripheral exterior edge, -at least two tongues extending from one face of the mesh, and -at least one member for reinforcing said mesh, characterized in that said reinforcing member takes the form of a frame fastened to said mesh and substantially adopting the shape of said peripheral exterior edge of the mesh, said frame being set back from said peripheral exterior edge and being provided with two hinge points, the line passing through said two hinge points also passing through the centre of the mesh and thus forming a line or folding the mesh in two.