Abstract: Indolyl or indolinyl compounds of formula (I): wherein bond, n, R1, R2, R3, R4, R5, and R6, are defined herein. Also disclosed is a method for treating cancer with these compounds.

Abstract: The present invention provides a novel xanthone derivative compound or a pharmaceutically acceptable salt thereof. The compound is useful as a chemosensitizer that reduces anticancer drug resistance.

Abstract: The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

Abstract: This invention provides an agent for inhibiting production of hepatitis C virus with notable anti-HCV activity and without side-effects. The agent comprises a proanthocyanidin polymer composition illustrated in the following the general formula (1), wherein R1 is hydrogen or hydroxyl, R2 is hydroxyl, R3 is hydrogen when R1 is either hydrogen or hydroxyl, but R3 is possibly hydroxyl when R1 is either hydrogen or hydroxyl to the extent that both R1 and R3 being hydroxyl is at most 40 percents in the proanthocyanidin polymer composition said units of flavan-3-ol being bonded each other in any one of three patterns as follows; (i) a bond between carbon at the position 4 and carbon at the position 8, (ii) a bond between carbon at the position 4 and carbon at the position 6, (iii) a bond between carbon at the position 4 and carbon at the position 8, and between carbon, at the position 2 and oxygen at the position 7.

Abstract: Isoflavone fatty acid ester derivatives of formula (I) or (II), the preparation method thereof and the pharmaceutical compositions containing such compounds are disclosed. The uses of such compounds in preparation of medicaments for preventing or treating hyperlipidemia, obesity or type II diabetes are also disclosed.

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Abstract: This invention relates to azeotrope-like compositions, methods and systems having utility in numerous applications, and in particular, uses for azeotrope-like compositions comprising effective amounts of the compound cis-1,1,1,4,4,4-hexafluoro-2-butene (Z-HFO-1336mzzm), which has the following structure: and another material selected from the group consisting of water, fluoroketones, alcohols, hydrochlorofluoroolefins, and combinations of two or more thereof. These compositions may be used in a wide variety of applications such as, blowing agents, refrigerants, heating agents, power cycle agents, cleaning agents, aerosol propellants, sterilization agents, lubricants, flavor and fragrance extractants, flammability reducing agents, and flame suppression agents.

Abstract: The use of sulfonamides of formula (I) wherein R and R1 are as defined in the description, for the preparation of medicaments for the prevention of diabetes, in particular of type-1 diabetes is herein disclosed.

Abstract: This invention provides SARM compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and/or disorder or a bone-related disease and/or disorder.

Abstract: Methods for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside or an anthocyanin are provided. More particularly, a method for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside having the structure of formula (IV): Formula (IV) wherein R is selected from H or CH3 or an anthocyanin selected from cyanidin 3-glucoside, delphinidin 3-glucoside, or combinations thereof, or an enantiomer, optical isomer, diastereomer, N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof is provided. Also provided are compounds according to Formulas I-IV, pharmaceutical compositions, unit dosage forms, and food or feed supplements containing such compounds.

Abstract: Methods for treating abnormal glycosylated hemoglobin (HbA1c) levels in a patient in need thereof, wherein the provided methods comprise administering to a patient in need a therapeutically effective amount of an Interleukin-1? modulator. Also, the invention provides compositions comprising at least one lipid modifying agent and an IL-1? modulator.

Abstract: The present invention relates to the use of a low-caloric high-protein nutritional composition for use in the prevention or treatment of a disease or condition in a mammal, which involves muscle decline, as well as to specific low-caloric high-protein nutritional compositions for stimulating muscle protein synthesis in a mammal.

Abstract: The present invention relates to novel dihydronaphthalene and naphthalene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.

Abstract: Gemcabene, a carboxyalkylether, is effective in the treatment and prevention of pancreatitis in subjects. The compound can be administered in an effective dose as the free acid, a pharmaceutically acceptable salt, or an ester or pro-drug that is hydrolyzed or otherwise metabolized in situ to gemcabene as the free acid or salt thereof.

Abstract: Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomer solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formulas I and II for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]propanamides, and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight. The process is carried out by submitting the Schiff bases intermediates 2-[4-(3- and 2-fluorobenzyloxy)benzylideneamino]propanamides to a reduction reaction with a reducing agent selected from sodium borohydride and potassium borohydride in an appropriate amount of an organic solvent selected from C1-C5 lower alkanols, allowing the formation and presence during a substantial position of the reduction reaction course of a suspension of the Schiff base into the saturated solution of the Schiff base into the same organic solvent.

Abstract: The present invention provides a method for preferentially reducing the proliferation of cystic epithelial cells in the kidney or bile duct in a mammal in need thereof by administering a 20-HETE synthesizing enzyme inhibitor or a 20-HETE antagonist to the mammal in an amount sufficient to preferentially reduce the proliferation of cystic epithelial cells over normal epithelial cells such as tubule epithelial cells in the kidney or bile duct. The present invention also provides a method for preventing or treating autosomal dominant polycystic kidney disease (ADPKD), autosomal recessive polycystic kidney disease (ARPKD), ARPKD associated congenital hepatic fibrosis, ARPKD associated Caroli's disease, or cholangiocarcinoma in a mammal in need thereof by administering a 20-HETE synthesizing enzyme inhibitor or a 20-HETE antagonist to the mammal in an amount sufficient to prevent or treat the disease.

Abstract: A pharmaceutical combination comprising as components (a) at least one 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol compound, and (b) at least one NMDA-antagonist, a pharmaceutical formulation and a dosage form comprising such a combination, and a method of treating pain, e.g. inflammatory pain or neuropathic pain, in which components (a) and (b) are administered simultaneously or sequentially to a mammal, with component (a) being administered either before or after component (b), and with components (a) or (b) being administered to the mammal either via the same pathway of administration or via different pathways of administration.

Abstract: Provided is a drug substance and a method of treating an ailment comprising administering an oral dose of a drug product comprising the drug substance wherein the drug substance comprises an organic acid addition salt of methadone. The organic acid addition salt is selected from the group consisting of pamoate and xinafoate wherein the drug substance is bioavailable under gastrointestinal administration but is not bioavailable under administration at a mucosal membrane other than gastrointestinal or release from a depot injectable product.

Abstract: Compositions (3) and methods of using such compositions (3) to condition, clean, or disinfect the flow path of a conduit (8) of a microfluidic devices (16), such as flow cytometers or liquid chromatographs.

Abstract: Novel Uses of small molecules, particularly, triterpenoids and ingol diterpenes isolated from Euphorbia neriifolia, are disclosed herein. The triterpenoids are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer; whereas the ingol diterpenes are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating thrombocytopenia.

Abstract: A novel composition made of polyalkoxylated derivatives of trimethylolpropane and fatty alcohols, the composition lending itself to the preparation thereof and to the use thereof as a reversing agent for a reversible reverse latex.

Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

Abstract: The present invention relates to a pharmaceutical composition comprising a pharmaceutical agent and a pharmaceutically acceptable carrier, which carrier comprises a protein, for example, human serum albumin and/or deferoxamine. He human serum albumin is present in an amount effective to reduce one or more side effects associated with administration of the pharmaceutical composition. The inventor also provides methods for reducing on or more side effects of administration of the pharmaceutical composition, and methods for enhancing transport and binding of a pharmaceutical agent to a cell.

Abstract: The invention relates to a sol containing silica-based particles having an axial ratio of at least about 10 and specific surface area of at least about 600 m2/g. The invention further relates to a sol containing silica-based particles having an axial ratio of at least about 10 and S-value up to about 25. The invention further relates to a sol containing silica-based particles having an axial ratio of at least about 10 and a specific surface area of at least about 400 m2/g, wherein the silica-based particles are surface-modified. The invention further relates to a sol containing silica-based particles having a viscosity of at least 50 cP and silica content of at least about 3% by weight, wherein the silica-based particles have a specific surface area of at least about 400 m2/g.

Abstract: This invention relates to a method for manufacturing a cation exchange resin, wherein the method includes the steps of: copolymerizing a monovinyl aromatic monomer and a cross-linkable aromatic monomer to obtain a cross-linked copolymer; specifying a content of a leachable compound represented by formula (I) to be 400 ?g or less relative to 1 g of the cross-linked copolymer, wherein Z represents a hydrogen atom or an alkyl group, and l represents a natural number; and then sulfonating the cross-linked copolymer to form a sulfonylated cross-linked copolymer.

Abstract: The present invention relates to a resin composition for a polyolefin resin foam, including: a polyolefin (A) having a melt flow rate (MFR) at a temperature of 230° C. of 0.2 to 0.7 g/10 min and a melt tension at break measured at a temperature of 190° C. of 30 cN or more; and a polyolefin (B) having a melt flow rate (MFR) at a temperature of 230° C. of 1.5 to 10 g/10 min and a melt tension at break measured at a temperature of 190° C. of 10 cN or more, in which the polyolefin (B) is contained in an amount of from 15 to 75 parts by weight based on 100 parts by weight of the polyolefin (A).

Abstract: Processes comprising: (a) providing a composition comprising at least one silane-terminated polyurethane preploymer prepared by a process comprising: reacting (A) at least one polyether having a number average molecular weight (Mn) of 2000 to 8000 g/mol, and comprising 10 to 30 wt % ethylene oxide units based on all alkylene oxide units in the polyether; with (B) at least one isocyanate and alkoxysilane group-containing compound of the formula (I): wherein each of X, Y, and Z independently represents a C1-C8 alkyl or a C1-C8 alkoxy residue, with the proviso that at least one of X, Y, and Z represents a C1-C8 alkoxy group; and wherein R is an at least bifunctional, organic residue; (b) foaming the composition, and (c) curing the foamed composition in the presence of water; and uses of polyurethane foams prepared thereby.

Abstract: Composite materials and methods for their preparation are described herein. The composite materials include a polyurethane made from the reaction of an isocyanate and a mixture of polyols, and coal ash (e.g., fly ash). The mixture of polyols comprises at least two polyols including a high hydroxyl number polyol having a hydroxyl number greater than 250 and comprising from about 1% to about 25% by weight of the total polyol content used to form the polyurethane, and a low hydroxyl number polyol having a hydroxyl number of 250 or lower. The coal ash is present in amounts from about 40% to about 90% by weight of the composite material. Also described is a method of preparing a composite material, including mixing an isocyanate, a mixture of at least two polyols, coal ash (e.g., fly ash), and a catalyst.

Abstract: A variety of biomedical devices are provided which include thiol-ene or thiol-yne shape memory polymers. The biomedical devices of the invention are capable of exhibiting shape memory behavior at physiological temperatures and may be used in surgical procedures. Methods of making the devices of the invention are also provided.

Abstract: Ultraviolet light-curable deposits are printed onto a substrate in a predetermined pattern to make tactile marks (e.g. Braille-like resin dots) for use by people with impaired vision to, for example, recognize the denominations of banknotes. The deposit demonstrates high adhesion due to: (1) presence of 20-80% (wt.) of a low viscosity acrylate component to provide a substrate-penetrating property; and, (2) 2-30% (wt.) of an adhesion-promoting acid acrylate. The deposit material further includes 1-30% (wt.) of urethane acrylate, 1-30% by weight of reactive diluent, photoinitiator and 1-10% (wt.) of rheological adsorbing additive. Optimally, the adhesion promoter is added after the other components have been mixed with the rheological additive. The printing step may be followed by heating before the curing step to increase penetration of the ink into the substrate. The deposit may comprise a taggant for use as a security feature.

Abstract: The present invention provides an energy ray-curable ink composition excellent in the continuous discharge property, and excellent in curability and adherability. The present invention relates to an energy ray-curable ink composition which contains a coloring agent, contains only a monofunctional monomer having an acrylic equivalent of 300 or less, and having one ethylenic double bond in one molecule, and a polyfunctional monomer having an acrylic equivalent of 150 or less, and having two or more ethylenic double bonds in one molecule as a polymerizable compound, contains an ?-aminoalkylphenone compound and a thioxanthone compound as a photopolymerization initiator, and contains a silicone compound having a polydimethylsiloxane structure as a surface conditioner.

Abstract: A friction element for a synchronizing device as well as an apparatus for producing a friction element for a synchronizing device are disclosed.

Abstract: Oil compositions having a high concentration of polyunsaturated fatty acids are described for use in various applications including use as drying oils, in ink compositions and coating compositions. Oil compositions wherein the double bonds of the fatty acids are substantially epoxidized are described and used as plasticizers and thermal stabilizers for various halogenated polymer compositions.

Abstract: An ink for inkjet computer-to-plate and a preparation method of the same are provided. Calculated in mass percentage based on the total mass of the ink, the ink comprises 10%˜30% of cross-linkable resin, 10%˜35% of solvent with a low boiling point, 5%˜30% of poor solvent with a high boiling point and 5%˜75% of bulk solvent. The preparation method comprises the following steps: mixing the above components and agitating at room temperature; after the cross-linkable resin is dissolved, ball milling and filtrating to remove insoluble substance and/or impurities in the liquid obtained by the ball milling. The ink can be formed into an image by printing on the treated surface of aluminum plate using ink-jet printer, and after heat cured, it can form an image with a high resolution and be used to print directly on machine, thus reducing post treatment process and obtaining the plate of ink-jetting direct plate-making.

Abstract: Pigment granules comprise one or more flake-form effect pigments, polymer particles or polymer particle mixtures, adhesion promoters, antioxidants and optionally additives. A process for the preparation of pigment granules comprises mixing one or more flake-form effect pigments, one or more polymer particles, at least one adhesion promoter, at least one antioxidant and optionally one or more additives with one another simultaneously or successively. The pigment granules may be used for the pigmentation of powder coatings, plastics and for the preparation of masterbatches. The pigment granules may be employed as a mixture with plastic powders or as a mixture with plastic granules for use in masterbatch applications.

Abstract: Additives for application in construction chemistry are proposed comprising an organic and/or inorganic core component A) with rheology-enhancing properties and a shell component B) applied to the same by virtue of physical and/or chemical interactions which acts as a coating. Component A) should be a of water-soluble and/or water-swellable and/or water-absorbable compound of the non-cellulose type with viscosity-enhancing properties in the final application. The shell component B) should preferably be a film-forming polymer which is able to release component A) during the application in construction chemistry in a retarded manner such as for example polyvinyl alcohol, polyvinyl acetate and polyethylene glycol. Component B) can be composed of several layers and comprises at least one reactive layer.

Abstract: The invention provides a method for manufacturing spherical, monodispersed core-shell type ceria-polymer hybrid nanoparticles including, a mixing step in which a cerium salt and a polymer are mixed together in a high-boiling-point organic solvent to obtain a mixture, and a heating and reflux step in which this mixture is heated and refluxed at a temperature of 110° C. or more to thereby generate a boiling phenomenon in the heating and reflux step, and rapidly cooling the mixture after the heating and reflux step to precipitate cerium oxide, and a liquid dispersion thereof.

Abstract: The invention relates to a radiation curable aqueously dispersed polyester resin composition containing an emulsifier D and the reaction product AC of a hydroxy functional polyester resin A and an olefinically unsaturated compound C which can be radically polymerized and which is attached to the polyester resin backbone by an ester linkage or a urethane linkage. The invention also relates to a process for its preparation and to a method of use thereof.

Abstract: Exemplary methods and compositions of the invention for retarding the surface of a hydratable cementitious composition comprise the use of a non-bituminous cationic emulsion comprising at least one curing compound comprising an acrylic polymer, a paraffin, or a mixture thereof, to hinder evaporation of water; at least one set retarder; and at least one cationic surfactant.

Abstract: A polyacetal resin composition containing 100 parts by weight of a polyacetal resin, 0.01 to 5 parts by weight of a colorant selected from inorganic and organic pigments, 0.01 to 3 parts by weight of a polyamide resin having a melting point or softening point of 180° C. or less, or a polyetheresteramide resin, 0.01 to 1 part by weight of an aromatic dihydrazide compound or an aliphatic dihydrazide compound having a solubility of less than 1 g relative to 100 g of water at 20° C., and 0.01 to 1 part by weight of a sterically hindered phenolic compound, or a combination of a hindered amine-based light stabilizer and an ultraviolet absorber, exhibits an excellent thermal stability and is capable of suppressing formaldehyde generation and mechanical strength deterioration.

Abstract: The present invention provides a phosphonate based compound (B) and a flame resistant thermoplastic resin composition including a thermoplastic resin (A) and the phosphonate based compound (B).

Abstract: A resin composition is provided. The resin composition comprises an epoxy resin, a hardener, and a modifier, wherein the modifier is a polymer solution obtainable from the following steps: (a) dissolving an N,O-heterocyclic compound of Formula I or Formula II into a first solvent to form a first reaction solution: (b) heating the first reaction solution to a first temperature to carry out a ring-opening polymerization to provide a solution of ring-opening polymerized product; and (c) cooling the solution of ring-opening polymerized product to a second temperature to substantially terminate the ring-opening polymerization to obtain the polymer solution, wherein, the first solvent is unreactive to the N,O-heterocyclic compound; the first temperature is higher than the softening temperature of the N,O-heterocyclic compound and lower than the boiling point of the first solvent; and the second temperature is lower than the first temperature.

Abstract: It is an object of the present invention to provide a tire rubber composition excellent in performances such as silica dispersibility and processability. The present invention relates to a tire rubber composition, comprising: a rubber component that contains an epoxidized natural rubber; silica; and a silane coupling agent, wherein the amount of the epoxidized natural rubber in 100% by mass of the rubber component is 15% by mass or more, the silica has a CTAB specific surface area of 180 m2/g or more and a BET specific surface area of 185 m2/g or more, and the silane coupling agent contains a mercapto group.

Abstract: A layered structure suitable for use in a pneumatic tire as an innerliner is prepared by directly bonding a fluid permeation prevention film and an adhesive tie layer. Prior to the bonding, the fluid permeation prevention layer is treated to remove any residual plasticizers or oils on the surface of the film. The tie layer comprises 100 weight % of at least one halogenated isobutylene containing elastomer and about 1 to about 20 parts per hundred (phr) of at least one tackifier. The fluid permeation prevention film comprises an elastomeric component dispersed in a vulcanized or partially vulcanized state, as a discontinuous phase, in a matrix of the thermoplastic resin component. The two layers of the layered structure may be separately extruded and then adhered to each other or adhered to each other during a calendaring operation wherein the adhesive tie layer composition is coated onto the treated film.

Abstract: A process for the preparation of a compound can have the formula wherein R1, R2 and R3 are independently selected from hydrogen and acyl groups, wherein at least one of R1, R2 and R3 is a branched chain long acyl group of the formula wherein n is from 9 to 21 and m is 2n, and wherein p is from 0 to 4, wherein the other of R1, R2 and R3 are selected from short acyl groups of the formula wherein q is from 0 to 4; the process comprising the steps of: (1) providing an unsaturated compound having the formula (2) if at least one of R1, R2 and R3 is hydrogen, optionally acylating the compound; and (3a) (i) hydroxylating the unsaturated long acyl group and (ii) acylating the hydroxy long acyl group, or (3b) reacting the unsaturated long acyl group with a carboxylic acid.

Abstract: The present invention provides a golf ball which includes (I) a first member composed of a material molded under heat from a rubber composition of (a) a base rubber composed primarily of a mixture of at least 60 wt % of a polybutadiene having a stress relaxation time (T80), as defined below, of less than 4 seconds and up to 40 wt % of a polybutadiene having a stress relaxation time (T80) of at least 4 seconds, (b) an unsaturated carboxylic acid and/or a metal salt thereof, and (c) an organic peroxide; and (II) a second member composed of a specific, highly-neutralized, resin composition. The golf ball of the invention, by being thus constituted, has an excellent resilience for the ball as a whole, a good, soft, feel on impact, and imparts an excellent spin performance, thereby enabling an increased distance to be achieved. In addition, it has a high manufacturability.

Abstract: Provided are a method for producing a polymer molded article, which is capable of increasing crystallinity, heat resistance, and isotropic elastic modulus while maintaining the original shape of a polymer molded body and a polymer molded article obtained by the method and having a high crystallinity, high heat resistance, and a high isotropic elastic modulus. The method for producing a polymer molded article includes the steps of: preparing a polymer material mainly containing a crystalline polymer; and impregnating the polymer material with a first gas having solubility in the crystalline polymer in an atmosphere in which the pressure of the first gas is equal to or higher than atmospheric pressure at a temperature higher than (Tm?30)° C. but lower than (Tm?15)° C., where Tm represents the melting point of the crystalline polymer, to obtain a polymer molded article. The polymer molded article is obtained by such a production method.

Abstract: A method for producing a modified smectite or smectite-containing substance including treating a non-activated smectite or substance with a water soluble activating agent and polymer in a two stage process, the first stage including adding 0-3.0% of the activating agent and 0.05-1.0% of the polymer, by weight, and in a second stage adding 0-5.0% of the activating agent 0.3-5% of the polymer, by weight, to the mixture of the first stage, wherein at least a part of the polymer is added as a dry solid and the water in the first stage is at least 20% by weight and at most 50% by weight in the second stage.

Abstract: Metallic ink compositions for use in capillary-action markers are provided. More particularly, a metallic ink composition includes an organic solvent, a metallic pigment, and a resin component.