Abstract: The present invention relates to an automatic torsion spring based injection device having a dial-up/dial-down mechanism by which a dose can be set by rotating a dose setting member in a first direction and which dose size can be reduced by rotating the same dose setting member in a second and opposite direction. The dial-up/dial-down mechanism operates a torsion spring which is strained when setting a dose and unstained when rotating the dose setting element in the second direction.

Abstract: Described is a syringe carrier comprising a body adapted to receive a barrel of a syringe. The body includes two sections having distal ends with shoulder sections. The shoulder sections are adapted to engage a circumferential gap between the barrel of the syringe and a needle shield covering a needle of the syringe.

Abstract: An injection device defines a longitudinal center axis, a proximal direction and a distal direction. The injection device includes a housing having a receptacle for an injection fluid vessel and an operator-manipulated element configured to be rotatable to set an amount of injection fluid to be dispensed. The operator-manipulated element is further configured to move relative to the housing in the direction of the center axis in the distal direction when rotated. The operator-manipulated element further is displaceable in the proximal direction to dispense injection fluid. A feed part is connected to the operator-manipulated element in a rotatably fixed manner and is displaced in the direction of the center axis in the distal direction during the setting of the amount of injection fluid to be dispensed. The feed part is connected to the housing in a rotatably fixed manner and is displaced in the direction of the center axis in the distal direction when the injection fluid is dispensed.

Abstract: A drive mechanism for a medication delivery device is proposed, the drive mechanism comprising a housing having a proximal end and a distal end, a rotation member which is adapted to be rotated in a first direction with respect to the housing during setting of a dose of a medication and to be rotated in a second direction with respect to the housing during delivery of the dose, the second direction being opposite to the first direction, a piston rod which is adapted to be displaced in a distal direction with respect to the housing for delivering the dose, a drive member which follows rotational movement of the rotation member in the second direction during delivery of the dose, and a stop member which prevents rotational movement of the drive member with respect to the housing in the first direction during setting of the dose, wherein the rotational movement of the drive member in the second direction is converted into movement of the piston rod in the distal direction with respect to the housing.

Abstract: The present invention relates to methods for reconstituting and relates to reconstitution devices suitable for reconstituting many different materials. Furthermore, the present invention includes methods of treatment and methods of use related to a reconstitution device or apparatus. Some embodiments are suitable for reconstituting small amounts of a pharmaceutical compositions and using the pharmaceutical composition for the treatment of sexual dysfunction.

Abstract: A syringe containing a compressible porous matrix, which compressible porous matrix has in it a pharmaceutical in a soluble glass, Methods of producing and using the syringe, and compressible porous matrix inserts for insertion into a syringe barrel are also provided.

Abstract: An injection device having a delivery element with an inner thread may be driven by rotation and includes a cylindrical outer wall region, which is substantially smooth. Such features provide a delivery element configured such that it is less intimidating to patients than known threaded rods, and may facilitate easy cleaning. The delivery element may be non-rotatably guided and axially spring-loaded, and may be inserted axially into the housing when the reservoir is replaced. The driving thread element for the delivery element may be mounted in the vicinity of the distal end of the housing.

Abstract: An infusion set system, including a base and a fluid connector removably coupleable thereto is disclosed. The fluid connector includes a fluid path portion and at least one connector latch displaceably connected to the fluid path portion and displaceable to a latching position in which at least a portion of the connector latch extends into the fluid path portion, which includes a cannula extending from a top interior surface thereof, and a plurality of internal sidewalls corresponding to at least two of a plurality of flat side surfaces of at least one of a base section and a base latch, thereby facilitating connection between the base and the fluid connector in a plurality of discrete rotational connecting positions. When the fluid connector is locked to the base, the at least one connector latch engages a base latching portion of the base and restricts proximal displacement of the fluid connector.

Abstract: The present invention relates to a blinding kit for administering a medicament to a patient in a clinical trial, the blinding kit comprising: a first blinding device having an opaque container and having an outlet for administering a liquid substance to a patient and having at least a first and a second inlet, wherein the first inlet is in permanent fluid communication with the outlet and wherein at least the second inlet is disconnected from the outlet, a second blinding device having an opaque container and having an outlet for administering a liquid substance to a patient and having at least two inlets, wherein said at least two inlets are in permanent fluid communication with the outlet.

Abstract: A connecting member removably connects a plurality of pen needles together, thereby providing a convenient way for a patient to carry multiple pen needles. The connecting member may be integrally formed with the outer cover of the pen needle or may be a separate member that removably receives the pen needle. An outer cover of a pen needle is provided with gripping means to facilitate gripping and handling of the outer cover. A lid connects to the outer cover to seal the outer cover. The lid also has gripping means to facilitate gripping and handling the lid. A cap is provided that has a first opening for receiving a first end of the outer cover and a second opening for receiving a second end of the outer cover.

Abstract: The present invention provides a novel drug delivery system for the controlled release of therapeutically active substances at a predetermined, essentially constant release rate over a prolonged period of time. The delivery system comprises at least one core comprising said therapeutically active substance(s), at least one membrane encasing the core and an intermediary layer of a substantially inert material, wherein the intermediary layer is applied between the core and the membrane or between two membrane layers.

Abstract: A device used for applying an antiseptic preparation to a surgical site of a patient prior to surgery outside of an operating theater. A loose-fitting bag is provided which encloses the surgical site by securing the open end(s) to the patient by closing means. A high friction scrub surface is provided in the bag. A method and apparatus are also provided for releasing antiseptic into the interior of the bag. The method provides that the surgical site can be scrubbed within the bag so as to properly prepare the skin for surgery. A temperature indicator for the antiseptic preparation is also provided.

Abstract: An eye drop device and a method of applying eye drops to the eye are disclosed herein. An exemplary embodiment of the device contains a main housing having an interior and exterior with a top opening sized to surround the eye and a bottom opening sized to accept the tip of an eye drop vial. The device also preferably contains a cavity for accepting the battery and an LED positioned within the interior of the main housing. A switch may be used to energize the LED. The method includes the steps of attaching an eye drop vial to the main housing, positioning the device over the eye, energizing the LED, and applying the eye drops.

Abstract: Toe JEMs is a decorative callous (corn) cover for toes compromised with rhinestones, gems, or other similar material and applied with a non-toxic skin adhesive. My invention addresses the issue of the unattractive appearance of a toe callous (corn) many women struggle with today. It gives women and or men a cosmetic option for their blemished toes. Instead of hiding their feet during the warm seasons of the year, Toe JEMs gives people the confidence to wear thong sandals, flip-flops, and open toe shoes or to just walk barefooted in public. Toe JEMs are a cosmetic answer to toe jams.

Abstract: The present invention relates to a dispenser comprising: a container defining a reservoir, said container having a resilient sidewall, a closed end, and a dispensing tip opposite the closed end, said dispensing tip including a passageway in fluid communication with the reservoir, and said resilient side wall including at least one finger indent; and a lid comprising a tube configured to cover the dispensing tip and an outer wall configured to align with the resilient side wall when the tube covers the dispensing tip, the outer wall including at least one finger indent;wherein the lid is removably connectable to the container by a threaded connection between the tube and the dispensing tip.

Abstract: This invention relates to a transdermal drug delivery device that comprises an active ingredient (AI) layer, having a skin contacting surface and a non-skin contacting surface and comprising a volatile component, a release liner impermeable to the volatile component adjacent the skin contacting surface of the Al layer having a perimeter that extends beyond the perimeter of the Al layer in all directions, and an overlay comprising a pressure sensitive adhesive (PSA) that does not absorb the volatile component adjacent the non-skin contacting surface of the Al layer having a perimeter of which extends beyond the perimeter of the Al layer in all directions, wherein the release liner and the PSA of the overlay are in contact with and adhered to each other around the perimeter of the Al layer to form a seal that reduces or prevents volatile component loss.

Abstract: A system, method, and apparatus are disclosed for dressing a wound and for minimizing scarring. The apparatus promotes scar-minimizing healing of a wound where negative pressure wound therapy is applied, and comprises a wound contact layer containing silicone, polysiloxanes, or other related compounds.

Abstract: A vacuum bandage is provided for use with a wound having a wound surface. The bandage is connectable to a vacuum source and includes a wound dressing member having a wound contacting surface, a top surface, and a port configured for communication with the vacuum source. The wound dressing member further includes holes in the wound contacting surface configured for communication with the wound surface of the wound and a passageway between the port and each hole. The vacuum bandage further includes a pack adjacent to the top surface of the member. The pack may include an aperture positioned about the port.

Abstract: The invention relates to a set of wound care articles, comprising at least one first planar wound care article comprising hydroactive polymers and at least one second wound care article comprising hydroactive polymers, wherein the second and optionally also any additional wound care articles have a lower liquid retention and/or a lower liquid absorption capacity than the first wound care article.

Abstract: The present invention relates generally to a device and method for treating tissues of the central nervous system and more particularly, but not exclusively, to a device and method for treating the brain tissue.

Abstract: Body-fluid containers, methods, and systems are presented that include a container that has a container housing formed, at least in part, by a liquid-impermeable, vapor-permeable material. The liquid-impermeable, vapor-permeable material allows water to evaporate and be transmitted outside of the container. The evaporation allows more fluid to be processed by the container than the container could otherwise hold. Other systems, methods, and apparatuses are presented.

Abstract: The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of swelling, compression, and compromised blood flow secondary to interstitial edema.

Abstract: An ostomy device including a bag, a lid, and a vent. The lid is replaceably attached to the bag, attaches to a site of a stoma of a patient, and self-seals to the stoma of the patient. The vent is operatively connected to the bag, and vents gas emanating from the stoma of the patient to prevent build-up of the gas that could detach the ostomy device from the site of the stoma of the patient and require rettachments that could irritate skin of the patient at the site of the stoma of the patient.

Abstract: The device (1) comprises: a first elongate impermeable receptacle (2), for accommodating the patient's penis, with an entry opening (20) and an exit opening (21), for evacuation of the urine, connected to a drain line (3); and a second receptacle (4) with a closed end (40) and which is connected during operation to the first receptacle by means of a strip (41), and an open end (42) for accommodating the patient's scrotum.

Abstract: An absorbent article including a temperature sensor, and at least one temperature change material arranged such that it is capable of affecting a temperature change due to a supply of excrement, and such that said temperature sensor is capable of being responsive to said affected temperature change. Also disclosed is a system for detecting a supply of excrement into an absorbent article, the system including an absorbent article being arranged to generate an output signal representative of the temperature, and a processing unit adapted to process an output signal generated by the temperature sensor. The processing unit is adapted to determine a change of temperature, wherein said change of temperature is affected by the temperature change material, and to detect a supply of excrement into the absorbent article based on the change of temperature.

Abstract: A method for detecting a liquid discharge event in an absorbent article including a sensor adapted to generate an electrical output signal representative of a degree of wetness of the absorbent article, wherein the electrical output signal is received by a processing unit. The method including the steps of providing reference data over time representative of a liquid discharge; acquiring liquid discharge data over time in form of the electrical output signal; analysing the liquid discharge data over time in relation to the reference data over time by the processing unit; and detecting a liquid discharge event based on the analysis. Also disclosed is a system for detecting liquid discharge event in an absorbent article including an absorbent article including a sensor being arranged to generate an output signal representative of an electrical property, and a processing unit adapted to process the output signal generated by the sensor of the absorbent article.

Abstract: An absorbent article having a first containment flap and a second containment flap each having a stem, an inner flap projection, and an outer flap projection. The stems of the first and the second containment flaps can be positioned laterally inward of the longitudinal side edges of the absorbent article. The stem can extend away from the body facing liner when the absorbent article is in a relaxed condition. The inner flap projection can extend laterally from the stem towards a longitudinal axis of the absorbent article and the outer flap projection can extend laterally from the stem away from the longitudinal axis and the inner flap projection when the article is in a relaxed condition. The outer flap projection can be bonded to the stem in at least a portion of one of the front waist region and the rear waist region.

Abstract: The Keneric brief pouch is a thin miniature absorbent pouch that attaches to Under garments. It is designed to capture leaking body fluids after urination In a secured pouch. It is attached with an adhesive backing to under Garments to hold the male organ in place to prevent staining to clothing after Urination. Keneric brief pouches can be discarded after use or being worn t To prevent incontinence accidents.

Abstract: A diaper and method for using the diaper are provided. The diaper includes an impermeable outer layer; an absorbent inner layer; and a collector bag including an opening and an adhesive surrounding the opening; the collector bag being removably attached to the absorbent inner layer.

Abstract: A mechanical fastener is disclosed that includes a thermoplastic backing and multiple, upstanding fastening elements that have a post with a proximal end attached to the thermoplastic backing and a distal end comprising a cap larger in area than a cross-sectional area of the post. The basis weight of the mechanical fastener is in a range from 25 grams per square meter to 75 grams per square meter, and the height of the multiple, upstanding fastening elements is up to 300 micrometers. Fastening systems and disposable absorbent articles including the mechanical fastener are also disclosed.

Abstract: An absorbent article having a first and a second containment flap each having a stem, an inner flap projection, and an outer flap projection. The absorbent article can include a first and a second folding line for packaging each being substantially parallel to the longitudinal axis. The first and second containment flaps can be positioned in the absorbent article such that the distal end of the outer flap projections can be positioned laterally inside of each folding line, the distal ends of the inner flap projections can be positioned laterally outside of each folding line, or such that the first fold line extends through at least a portion of the inner or the outer flap projection of the first containment flap and the second fold line extends through at least a portion of the inner or the outer flap projection of the second containment flap.

Abstract: A pelvic-abdominal support garment including a waist encircling band having shorts secured to the lower edge thereof, the shorts having a receptacle for receiving an ice pack, and a strap member secured at one end thereof to the back of said waist encircling band and the other end thereof attachable to the front of the waist encircling band after passing under the crotch region of the shorts to apply pressure to the crotch area of the wearer.

Abstract: A fluid control system for delivery of a liquid includes a pneumatic drive that incorporates a linear actuator to effect known volume changes in a gas reservoir. The gas reservoir is in fluid communication with a gas-side reservoir that is separated from a fluid-side reservoir by a flexible membrane. Movement of the linear actuator effects positive or negative volume differences on the gas in the gas-side reservoir, resulting in a decrease or increase in pressure of the gas that is transmitted to the fluid-side reservoir to draw fluid, primarily liquid, in from a source or deliver liquid out to a sink. In another aspect, a mechanism is provided for the detection and elimination of air bubbles in the fluid path.

Abstract: A fluid control system for delivery of a liquid includes a pneumatic drive that incorporates a linear actuator to effect known volume changes in a gas reservoir. The gas reservoir is in fluid communication with a gas-side reservoir that is separated from a fluid-side reservoir by a flexible membrane. Movement of the linear actuator effects positive or negative volume differences on the gas in the gas-side reservoir, resulting in a decrease or increase in pressure of the gas that is transmitted to the fluid-side reservoir to draw fluid, primarily liquid, in from a source or deliver liquid out to a sink. In another aspect, a mechanism is provided for the detection and elimination of air bubbles in the fluid path.

Abstract: Cerebral Catheter devices and methods for use are provided. The catheter devices provided may include an anti-thrombotic agent coating on the exterior surface. The catheter devices may include unique tip configurations to allow improved fluid delivery capabilities. Further, the catheter devices may also or alternatively include one or more sensor devices in communication with a controller that allow automatically adjusting the delivery of a therapeutic fluid, for example a vasodilator, in response to the condition sensed by the catheter device, such as increased pressure. Moreover, the catheter devices may also be used in conjunction with blood flow transducers to detect and timely prevent and treatment vasospasms or other conditions. Methods for preventing and treatment vasospasm, neoplasm, or other pathological conditions while prolonged using the catheter device are also provided.

Abstract: An infusion system for being operatively connected to a fluid delivery line and to an infusion container includes a pump, a plurality of different types of sensors connected to the pump or the fluid delivery line, at least one processor, and a memory. The plurality of different types of sensors are configured to indicate whether air is in the fluid delivery line. The memory includes programming code for execution by the at least one processor. The programming code is configured to, based on measurements taken by the plurality of different types of sensors, determine: whether there is air in the fluid delivery line; whether there is a partial occlusion or a total occlusion in the fluid delivery line; or a percentage of the air present in the fluid delivery line or the probability of the air being in the fluid delivery line.

Abstract: Methods are disclosed for delivering a substance to the skin of a human subject. The methods include, obtaining a substance, such as hormones, for example, Insulin; and delivering the substance into an intradermal space within the skin of the human subject through a plurality of microneedles. The microneedles are of a height of approximately 400 micrometers to approximately 750 micrometers.

Abstract: A new flexible surgical drain/catheter system is provided. The flexible system encompasses a flexible section that can be incorporated in the design of surgical drains/catheters of any kind. By incorporating this flexible system, a surgical. drain/catheter will possess three significant additional characteristics. These additional characteristics will make the herein designs superior to the existing designs. The first characteristic is that the surgical drain/catheter can be bent without causing any fold/crease to its outer and inner surfaces. The second characteristic prevents internal occlusions while the drain/catheter is bent. The third characteristic is that the flexible section can also be used as a reliable region of drain/catheter anchorage to the patient's body.

Abstract: Described herein are syringe accessories that can be attached to standard syringes. These accessories utilize one or more mechanisms that can provide at least one additional sensory feedback to the user when performing an aliquot or dosed injection. In other embodiments, the accessories can prevent overdosing.

Abstract: Described are devices and systems for protection of injectable substances such as adipose cells from excessive stress or pressure during injection procedures. Further described are stress control mechanisms for detecting and/or controlling stress or pressure within injection devices.

Abstract: Described herein are syringe extrusion accessories comprising: a handle operatively coupled to an attachment portion configured to attach to a syringe; and at least one prawl operatively coupled to the handle and configured to engage with a plunger of the syringe, wherein the syringe extrusion accessory is configured to transfer a substantially perpendicular force applied to the handle to an axial force to push the plunger and extrude a product from the syringe.

Abstract: A catheter guidewire for facilitating introduction of a flexible catheter into the human body (e.g., into the bladder) has a proximal end having a first stiffness which is sufficient to facilitate guidance of a stiff plastic expansion sheath through the tissue. A distal end of the guide wire has a second stiffness, substantially less than the first stiffness, to avoid damage to internal walls of the bladder. Preferably, the guide wire incorporates an intermediate portion having a stiffness between the first stiffness value and the second stiffness value.

Abstract: A system for accessing a sinus cavity of a subject includes an access tool configured to penetrate into the sinus cavity from a location external the subject. The system further includes an access sheath having a distal tubular portion, a lumen extending through the access sheath and the distal tubular portion and dimensioned to receive the access tool, the distal tubular portion comprising one or more cutting surfaces disposed about an external surface thereof. The one or more cutting surfaces may include a plurality of longitudinally oriented grooves for flutes disposed about the periphery of the distal tubular member.

Abstract: The fluid injector system includes a source of injection fluid, a pump device, a fluid control device operably associated with the pump device, and a fluid path set in fluid connection with the source of injection fluid and the pump device. The fluid path set includes a multi-patient fluid path section adapted for fluid connection to at least one pressurizing device, a per-patient fluid path section adapted for fluid connection with a patient and comprising at least one check valve, and a connector for removably and fluidly connecting the multi-patient fluid path section with the per-patient fluid path section.

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

Abstract: Embodiments of aortic occlusion devices are described herein that include radially expandable and collapsible proximal and distal end portions, such as annular self-expanding stents or frames, that are configured to radially expand within an aorta to secure the device within the aorta. The devices can also include a catheter extending axially between the distal end portion and the proximal end portion and a porous covering, or filter, positioned around the catheter and between the proximal end portion and the distal end portion and configured to filter emboli from blood flowing into upper-body arteries. The device can further include a one-way valve positioned at or adjacent to the distal end portion of the device and configured to restrict retrograde blood flow through the device toward the heart.

Abstract: A tool for engaging and withdrawing a wire guide from a patient includes a deformable distal segment having a self-expanding bias such that the distal segment assumes a tortuous configuration, and a control line attached to the distal segment and configured to extend through an intraluminal sheath, such that pulling the control line deforms the distal segment in opposition to the self-expanding bias to tighten about a wire guide. The tool may be withdrawn from the patient while tightened about the wire guide, such that the wire guide simultaneously extends out of the patient at each of a first and a second percutaneous entry point.

Abstract: E-Z Dose-pensing, is an improved assistive device for mixing and compounding medications Two different types of dispensers are provided. Liquid material is placed into the cap of the cup dispenser and solid material is placed into an inner chamber, when a twist seal is broken, the solid and liquid materials mix together. For the syringe dispenser, liquid is placed into an elongate tube and when the plunger of the syring is pushed, the liquid is pushed into a chamber having solid material, is shaken to mix the liquid an solid.

Abstract: A method and apparatus for reducing or eliminating pain after surgical procedures related to mucosal tissue, including tonsillectomy, adenoidectomy, or other pharyngeal operations. Certain embodiments provide a biodegradable film or covering that serves as a mechanical barrier to reduce pain caused, for example, by friction between solid food and healing tissue in the first few days after surgery. Some embodiments may include one or more therapeutic substances for locally reducing pain, facilitating healing and/or otherwise treating mucosal tissue at or near a tonsil bed.

Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.