Abstract: A disposable diaper is disclosed. The diaper includes a colored topsheet. The topsheet has a basis weight of from 12 to 18 gsm and comprises a plurality of bonded points. Each of the bonded points has a surface area of from 2 mm2 to 5 mm2 and the cumulated surface area of the plurality of bonded points is from 10 to 25% of the total surface area of the topsheet.

Abstract: A method of individually packaging an absorbent article and attaching the absorbent article to an undergarment including the steps of providing a tri-folded absorbent article having two end portions and an intermediate portion, providing a pouch containing the tri-folded absorbent article, opening the pouch to thereby expose a garment-facing surface of the intermediate portion of the absorbent article prior to exposing a garment facing surface of either of the end portions of the absorbent article.

Abstract: A diapering assistance system utilizes a diaper and a diaper holding member which retains the top end of the diaper and suspends its bottom end. A belt member attached to the diaper holding member, encircles the waist of the individual being diapered. The belt member has connection devices, such as hook and loop connectors, and constitutes the sole component used for attaching the system to the individual. The method of use includes securing the top end of the diaper to the diaper holding member, suspending the diaper therefrom and behind the individual to be diapered, encircling the individual with the belt element, and securing it around the individual's waist. The bottom end of the diaper is then lifted between the legs and to the front of the individual. The diaper is attached to the individual and the diaper holding member and belt member are removed.

Abstract: A force focused fastening system maintaining a fastener element in plane during fastening. The force focused fastening system includes a force focused fastening member including an extensible region and an end region. The end region includes a fastener element and the extensible region includes a high modulus region aligned relative to a center portion of the fastener element. During fastening, the force focused fastening member directs forces toward the center portion of the fastener element, away from end portions, minimizing distortion of the fastener element.

Abstract: A seat mechanism includes a front seat plate, left and right guide rails each having a longitudinal rail groove, a rear seat plate disposed on the guide rails, two protruding rods each protruding downward from a bottom surface of the rear seat plate to a corresponding guide rail, a plurality of guide members projecting sideward from each protruding rod and inserted into the rail groove of the corresponding guide rail such that each guide rail is slidable relative to the guide members of the corresponding protruding rod, and a plurality of fasteners each extending through the rear seat plate and detachably and selectively engaging one positioning hole in the guide rails for adjustably positioning the rear seat plate on the guide rails.

Abstract: A patient support system includes independently adjustable end columns supporting a centrally hinged, jointed or breaking patient support structure. At least one column includes a powered rotation assembly. The patient support includes at least two sections. A coordinated drive system provides for both upwardly and downwardly breaking or jointed orientations of the two sections in various inclined and tilted positions. Cable, cantilevered and pull-rod systems are included.

Abstract: A pediatric headrest for skull stabilization and a method for use of the same are disclosed. In one embodiment, a horseshoe shaped head support includes first and second wings pivotally coupled to a body to adjust the angle therebetween. A gel pad is superposed on the horseshoe shaped head support. First and second arcuate base members are coupled to the first and second wings, respectively, to accept a plurality of placement subassemblies, which are circumferentially adjustably positioned and secured within the channels. Each placement subassembly is configured to receive a skull pin and provide adjustable horizontal, vertical, and angular positioning of the skull pin with respect to the arcuate base.

Abstract: An apparatus for applying pressure to a body part comprising multiple interconnectable bands of compressible or noncompressible material. Optional spine to further interconnect the bands. Interconnectable pieces designed for covering specific body areas. Modular arrangement of the individual components. Customized or off-the-shelf availability of the apparatus.

Abstract: A garment for the treatment of venous stasis disease is directed to an inelastic self-adjusting graduated stocking which includes the stocking, a closure device and a fluid bladder. The stocking is comprised of an interior non-elastic mesh, preferably made of nylon.

Abstract: A limb wound treatment device is described having a first end, a second end and an interior therebetween for accommodating a treatment gas. The device can include a flexible housing that can be inflated. The first end can include an inflatable cuff seal for hermetically sealing against the limb being treated. The second end can include a closed end or an access port that is releasably sealed with a clamping mechanism. Further, the device can include a controller that can inflate that housing, inflate the cuff seal and provide treatment gas to the interior, in response to pressures within the cuff seal and the housing. Further, the device can accommodate different types of wound treatments, such as hyperbaric therapy, compression therapy or negative pressure therapy.

Abstract: A massaging applicator device for applying topical oils to an individual, such as a person or creature, and methods of applying topical oils are disclosed. Some embodiments of an exemplary massaging applicator device may include an applicator body containing a vibration assembly. A roller ball foot is coupled to the applicator body. The roller ball foot houses a roller ball. A container is selectively coupled to the roller ball foot and is configured to hold a topical oil. A flow switch is disposed between the container and the roller ball to selectively control flow of topical oil from the container to the roller ball.

Abstract: A hybrid chest compression device includes a backboard with a motor and a drive spool housed within the backboard. There is also a piston support frame secured to the backboard forming a patient channel between the piston support frame and the backboard. There is a belt operably secured to the drive spool and enclosed within the backboard and the piston support frame and a piston operably housed within the piston support frame wherein motion of the belt actuates motion of the piston. Actuation of the motor results in cyclic rotation and counter-rotation of the motor and corresponding winding and unwinding of the belt on the drive spool to effectuate cyclic extension and retraction of the piston against the patient's chest to perform mechanical cardiopulmonary resuscitation.

Abstract: An acupressure device for promoting healing includes a plate having a frame, a vertical center plane and independently moving left and right wings attached to the frame. Three horizontal pairs of acupressure protrusions are affixed on the left and right wings, each protrusion affixed equal-distant from the vertical center plane. A fourth horizontal pair of acupressure protrusion is affixed to a bottom portion of the frame, both protrusions affixed equal-distant from the vertical center plane. Finally, a fifth horizontal pair of acupressure protrusions is affixed on the left and right wings and positioned vertically between a lowest and a second lowest pair of the first four pairs of protrusions and is centered about the vertical center plane at a horizontal distance greater than a horizontal distance of the first four pairs of protrusions.

Abstract: A vial adapter for side engagement of a vial cap includes a needleless connector having a housing and defining one or more fluid pathways therein; an elongated piercing spike operatively coupled to the needleless connector, the elongated piercing spike having a longitudinal axis and one or more channels for fluid connectivity with the one or more fluid pathways; at least one housing arm coupled to the housing and extending parallel to the longitudinal axis; and a coupling member configured to orthogonally receive a vial cap with respect to the longitudinal axis, the coupling member having a planar surface, an aperture of the planar surface longitudinally aligned with the elongated piercing spike, and at least one support arm extending from the planar surface operatively coupled with the at least one housing arm to allow relative longitudinal movement between the coupling member and the elongated piercing spike.

Abstract: There is provided a cartridge for a medication dispensing apparatus having an auto locking function, the cartridge including a cartridge case; a drum; a cartridge base; and a driving means, wherein a hollow cylinder having a coupling groove drilled therein is formed at a center of a bottom of the drum, a lifting body having an elastic protrusion elastically coupled to the coupling groove is inserted into the cylinder, wherein, when a rotation shaft of the driving means is inserted into the cylinder, the lifting body moves upward and then the elastic protrusion is separated from the coupling groove, whereas, when the rotation shaft of the driving means is separated from the cylinder, the lifting body moves downward and then the elastic protrusion is coupled to the coupling groove.

Abstract: This invention provides a medication dispensing system that instructs the user through visual and audio cues, such as the illumination of individual medication cups that are arrayed in accordance with a daily and weekly schedule in separate orifices within the dispenser body. It monitors compliance by determining when an indicated cup is accessed, based upon at least one of manipulating a lid and/or placing into, removing from, or replacing into the correct orifice based upon the indication. The cups can be refilled based upon an indication, and/or can be provided in removable prefilled refill tray. The dispenser can include an on-board processor that stores a current configuration including the treatment schedule. The configuration can be programmed/re-programmed, and compliance can be monitored, via a wired or wireless server connection that communicates with interested parties, and that supports a graphical user interface. Communication, messaging and/or display systems can also be integrated.

Abstract: A configurable percutaneous endoscopic gastrostomy tube includes a shaft having a distal end and a proximal end. The shaft defines a lumen therethrough for passage of a feeding solution or medicine. An expandable retainer is located on the shaft, the retainer having a deployed position and an insertion position. The tube includes a releasable lock for maintaining the expandable retainer in its deployed position, the releasable lock located on the shaft proximal to the expandable retainer. A flexible sheath surrounds the expandable retainer, the sheath being generally loose around the retainer when the retainer is in an insertion position and the sheath being generally snug against an exterior surface of the retainer when the retainer is in a deployed position.

Abstract: The present invention relates in a first aspect to an adhesion material for use in an individual containing encapsulated phase-change material. In particular, the adhesion material is for cosmetical or medicinal use in the body of an individual. The adhesion material contains encapsulated phase-change material having preferably a phase transition temperature above 40° C., like above 55° C. The adhesion material is particularly useful for adhering elements, like dental restorations, e.g. crowns or bridge, or brackets on elements in the body of an individual, like teeth or implants. That is, the adhesion material is particularly useful for adhering material in dental applications. In another aspect, a method is provided allowing removing a bracket, a crown or bridge, from implants, abutments or teeth. Furthermore, dental implant restoration systems and kits for permanent fixation of implants allowing improved removal thereof are provided.

Abstract: The invention provides an infiltrant for dental application that comprises crosslinking monomers. In accordance with the invention the infiltrant has a penetration coefficient PC>50 cm/s, and comprises 0.05%-20% by weight of acid-group-containing monomers.

Abstract: The present invention provides a foam composition comprising an active agent. In particular, the foam composition produces a water resistant, preferably very water resistant, film upon application.

Abstract: Vesicle, comprising at least the following components: —an aqueous core, which can comprise at least one cosmetic and/or at least one pharmaceutical active substance, and —a continuous membrane which surrounds the core and which is formed by at least one emulsifier, selected from the group of the food additives E 472 a to f, and at least one membrane-stabilizing single-chain lipid and/or one or more lipophilic cosmetic and/or pharmaceutical active substances.

Abstract: The present invention provides an information exchange method, a user end, and a system for online collaborative shopping. The method includes: sending a collaborative shopping request message that includes one or more user identifiers to a collaborative server; receiving a collaborative shopping startup message; submitting a shopping web page of the main control user end to the collaborative server, and submitting, to the collaborative server, operation information generated when a user of the main control user end operates a shopping web page; and receiving operation information generated when a user on the collaborative user end operates a shopping web page according to a commodity feature concerned by the user on the shopping web page, and displaying, on the shopping web page, an operation result of the user on the collaborative user end for the shopping web page.

Abstract: The present invention relates to a multicomponent oral health care composition, comprising a source of a fluoride ion, a source of a calcium ion, a source of a phosphate ion, and stabilized chlorine dioxide, that can be used as a toothpaste, oral spray or a mouth wash/oral rinse formulation. The different components in the composition act synergistically together to clean the teeth and mucous membranes of an oral cavity of a subject, perfuming them or protecting them in order to keep them in good condition, change their appearance or correct unpleasant odors. They achieve this by inhibiting caries, promoting teeth remineralization, and helping to alleviate dentine hypersensitivity, gingivitis and periodontal disease.

Abstract: Provided is an oral composition that can sufficiently remove protein staining present on a tooth surface, can effectively prevent adhesion of protein staining on a tooth surface and can provide a good actual feeling of the cleaning effect in the oral cavity. The oral composition comprises the following components (A) and (B): (A) an N-acylamino acid or a salt thereof in an amount of 0.005 mass % or more and 0.3 mass % or less; and (B) pyrophosphoric acid or a salt thereof in an amount of 0.005 mass % or more and 0.5 mass % or less, in which a mass ratio ((B)/(A)) of the component (B) to the component (A) is 0.05 or more and 40 or less and a total content of the component (A) and the component (B) is 0.01 mass % or more and 0.6 mass % or less.

Abstract: A cosmetic composition for nails containing a concentration less than or equal to 1 wt % of at least one monoaldehyde of the formula (I): R—CHO, where R is C5-C12 linear alkyl radical or a C5-C12 alkenyl with an unconjugated double bond to the —CHO aldehyde group, as nail hardening agent, and provided in the form of a colored or colorless fingernail polish, a polish undercoat, a peelable polish, a beauty oil, an emulsion or an aqueous solution, or a gel. Also the use of aldehydes of the formula (I) for hardening and strengthening nails and to a method for applying same.

Abstract: The present application relates to a cosmetic composition comprising at least one ester corresponding to formula (I) below: R1COOR2??(I) in which R1 represents H or a linear or branched hydrocarbon-based radical, and R2 represents a linear or branched hydrocarbon-based radical, with the proviso that: when R2 is a linear hydrocarbon-based radical and R1 is H or a linear hydrocarbon-based radical, then 7?R1+R2?8; and when at least one of R1 and R2 is a branched hydrocarbon-based radical, then 8?R1+R2?10, with the proviso that, when R1 is tert-butyl, then R2 is not isohexyl. This composition can be used as a product for caring for and/or making up keratin materials, in particular the skin, the lips and/or the integuments.

Abstract: A method for anti-skin aging, especially for anti-skin photo-aging in a subject is provided. The method comprising administering to the subject an effective amount of an active component selected from the group consisting of a caffeamide derivative of formula (I), a pharmaceutically acceptable salt of the caffeamide derivative, and a combination thereof: wherein A is H or an alkyl; B is —[CH2]m—; m is an integer ranging from 0 to 10; R1 is H, an optionally substituted phenyl, an optionally substituted pyridyl, —OH, or —OCH3; or, N, A, B, and R1 together form an optionally substituted pyrrolyl or piperidyl.

Abstract: Provided is a composition that masks the odor characteristic of anisic acid or phenylalkanol, is superior in appearance and texture on application, and provides moist feeling to the skin after application. Specifically, a composition containing (A) acyl proline represented by the formula (I) or a salt thereof, and (B) one or more kinds selected from anisic acid and phenylalkanol is provided.

Abstract: The present invention relates to methods and compositions for inhibiting, treating, and preventing dental diseases in human and non-human animals, particularly domesticated companion animals. More particularly, the present invention relates to the unexpected discovery that the combination of micron-sized particulate bioactive glass and a topical bisphosphonate yields a composition that is capable of treating and/or preventing dental problems such as periodontal disease, tooth decay and tooth resorption in animals, particularly small mammals such as cats.

Abstract: A sprayable alcohol-based sunscreen comprises an alcohol carrier, at least one sunscreen additive, and a film forming polymer comprising shellac.

Abstract: A composition for topical application of a botulinum toxin (including botulinum toxin derivatives) comprises a botulinum toxin and a carrier comprising a polymeric backbone comprising a long-chain polypeptide or nonpeptidyl polymer having attached positively charged branching or “efficiency” groups. The invention also relates to methods for reducing muscle paralysis and other conditions that may be treated with a botulinum toxin, particularly paralysis of subcutaneous, and most particularly, facial, muscles, by topically applying an effective amount of the botulinum toxin and carrier, in conjunction, to the subject's skin or epithelium. Kits for administration are also described.

Abstract: One aspect of the invention relates to caffeine-containing compositions comprising caffeine and one or more esters. The caffeine-containing compositions disclosed herein can be used for effective transdermal delivery of caffeine to a subject. Another aspect of the invention relates to applications and preparations of the caffeine-containing compositions.

Abstract: Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent.

Abstract: Injectable formulations of water-soluble salts of diclofenac, which cause significantly less pain at the site of injection and can be administered by intradeltoid route, in addition to intragluteal and slow intravenous route.

Abstract: A method includes (i) contacting a polymeric material with a first solvent to produce a pre-extracted polymeric material, and (ii) contacting the pre-extracted material with a solution comprising one or more therapeutic agents and a second solvent to incorporate the therapeutic agents into the pre-extracted polymeric material. The first or second solvents are the same or different.

Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.

Abstract: The invention provides an ophthalmic product containing rebamipide, which has a transparency enough to be agreeable feeling on using it and has neutral to weakly acidic pH not to injury of the keratoconjunctiva of a patient suffering from dry eye. An aqueous suspension of crystalline rebamipide which has an improved transparency is provided by adding an aqueous solution of rebamipide dissolved by a base such as sodium hydroxide or an aqueous solution of a salt of rebamipide to an aqueous acidic solution such as hydrochloric acid containing at least one of the compounds selected from water-soluble polymers and surfactants, and mixing them.

Abstract: The present disclosure relates to a face support that has a built-in drug carrier containing medicinal ingredients for protecting eyes from diseases and reducing wrinkles around the eyes. The face support having a drug carrier according to the present disclosure is designed to cover a facial area around the eyes and comprises: a housing with a predetermined installation space defined therein and a plurality of vent holes formed in one side in the proximity of the globe of the eye when the face support is worn, the vent holes serving to communicate the installation space with the outside; a main body having a fixing member for fixing the housing to the face of a user; and a drug carrier installed inside the main body and containing medicinal ingredients useful for protecting the eyes from diseases and relieving eye fatigue. The drug carrier comprises a medicinal herb layer containing the medicinal ingredients to enable transdermal delivery of the medicinal ingredients.

Abstract: The present invention provides a wound healing composition comprising a biocompatible hydrogel membrane wherein the hydrogel membrane has one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The invention further provides methods of treating a wound in a subject in need thereof, comprising contacting the wound with a biocompatible cellulose hydrogel membrane of the invention.

Abstract: Oral dosage forms of osteoclast inhibitors, such as nitrogen-containing bisphosphonates, can be used to treat or alleviate pain or related conditions.

Abstract: A stable, taste-masked, ready-to-use suspension comprising rifaximin dispersed in a suspension base and one or more pharmaceutically acceptable additive(s). Also provided is a process for preparing a stable, taste-masked, ready-to-use suspension of rifaximin comprising the steps of mixing rifaximin with the suspension base and further sizing the particles of rifaximin by milling the suspension to obtain a homogenously dispersed rifaximin suspension.

Abstract: The present invention relates to a therapeutic kit to provide a safe and effective dosage of an antibiotic agent, including an aerosol packaging assembly including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam, wherein the pressurized product comprises a foamable composition including: an antibiotic agent; at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, an organic polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight, a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water; and liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

Abstract: Provided herein are methods of preventing or reducing the effects of exposure to a mustard compound. The methods include the steps of contacting cells exposed to a mustard compound or at risk of exposure to a mustard compound with a composition comprising a polypeptide comprising RLIP76 or an active fragment or variant thereof. Optionally, the methods include the steps of administering to a subject exposed to a mustard compound or at risk of exposure to a mustard compound a composition comprising a polypeptide comprising RLIP76 or an active fragment or variant thereof.

Abstract: High loading immediate release dosage forms containing at least 30 wt % of a solid drug dispersion, at least 5 wt % of a disintegrant and a porosigen are disclosed that exhibit excellent strength and aqueous solubility.

Abstract: Injectable pharmaceutical compositions containing 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione dimaleate as active ingredient in the form of a lyophilized powder with a carrier selected from lactose and dextran, mixed with sodium chloride.

Abstract: Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.

Abstract: The present invention provides an oral pharmaceutical formulation comprising coated spheroids of a kinase inhibitor such as neratinib, which formulation is designed to reduce or eliminate side effects associated with existing oral formulations of kinase inhibitors.

Abstract: The present invention is directed to a tablet comprising at least one bitter tasting and/or mucosa numbness causing pharmaceutically active compound; and at least one zinc salt. In addition, the present invention relates to the use of a zinc salt to reduce or mask the bitter taste of or the numbness of the mucosa caused by pharmaceutically active compounds.

Abstract: An object of the present invention is to provide a cell construct for cell transplantation capable of having a thickness suitable for cell transplantation, preventing the necrosis of transplanted cells, and forming blood vessels in the transplantation site after transplantation. The present invention provides a cell construct for cell transplantation which comprises polymer blocks having biocompatibility and cells of at least one type, wherein the plural polymer blocks are arranged in spaces between the plural cells.

Abstract: A polymer-based preparation in film form for biphasic release of substances present therein to liquid surroundings, is characterized in that the preparation comprises at least two polymer matrix layers which differ in terms of their construction from polymers, with release taking place rapidly from one of the layers, and release taking place slowly from at least one other layer.