Patents Issued in January 26, 2016
  • Process for hydroconversion of heavy carbon-containing feedstocks that integrate a boiling-bed technology and a slurry technology
    Patent number: 9243194
    Abstract: The invention relates to a process for hydroconversion of heavy carbon-containing feedstocks that comprises a stage (1) for hydroconversion of the feedstock in at least one reactor that contains a boiling-bed catalyst and then a stage (2) for hydroconversion of at least a portion of the effluent that is obtained in at least one reactor that contains a slurry catalyst.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: January 26, 2016
    Assignee: IFP ENERGIES NOUVELLES
    Inventors: Frederic Morel, Patrick Sarrazin, Alain Quignard, Jan Verstraete
  • Process and apparatus for fluid catalytic cracking and hydrocracking hydrocarbons
    Patent number: 9243195
    Abstract: A process and apparatus for recovering cycle oil from FCC CSO is described. By feeding the additional cycle oil to a hydrocracking unit additional diesel, naphtha and petrochemical feedstock may be obtained. The additional cycle oil is obtained by vacuum separation of the CSO. The described process and apparatus can provide additional recovery for a refiner.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: January 26, 2016
    Assignee: UOP LLC
    Inventors: Jibreel A. Qafisheh, Boyd E. Cabanaw, Xin X. Zhu
  • Process using natural gas partial oxidation to condition syngas from gasification of other fuels
    Patent number: 9243196
    Abstract: A method of processing synthesis gas improves the quality of the synthesis gas by using a water gas shift reaction to increase the molar ratio of hydrogen to carbon monoxide (H2:CO) in an efficient manner. A first steam of hot natural gas-based synthesis gas having a first higher molar ratio of H2:CO is combined with a second stream of quenched synthesis gas having a second lower molar ratio of H2:CO to provide a blend of synthesis gas having a third molar ratio of H2:CO that is between the first and second molar ratios. A non-catalytic water gas shift reaction increases the molar ratio of H2:CO to a fourth molar ratio that is higher than the third molar ratio, and can be about equal to or greater than the first molar ratio without supplying external heat.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: January 26, 2016
    Assignee: Gas Technology Institute
    Inventors: Bruce G. Bryan, Arunabha Basu, Howard S. Meyer
  • Radiant heat flux enhanced organic material gasification system
    Patent number: 9243197
    Abstract: A system for producing superior quality synthesis gas (“syngas”) consisting of a series of chambers in which the gasification stages of reaction, homogenization and activation occur. The first stage reaction stage agitates and combines the reactants, consisting primarily of organic matter, oxidizer and steam, to initiate gasification of the organic and volatile fraction and to transport the inorganic residue to continuous removal. In the homogenization chamber, turbulence is induced by injecting gaseous species. The gas mixture emerging from the homogenization chamber is accelerated via a third stage communicating duct and is introduced tangentially into the fourth stage activation chamber inducing a cyclonic motion wherein a high intensity radiant heat source is introduced along the central axis of the gas vortex.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: January 26, 2016
    Assignee: Enersol Power LLC
    Inventors: Kenneth Hladun, Jayaraman Ramamurthi, Mark Edward Vetter, Yuji Kado
  • Methods and compositions for the recombinant biosynthesis of n-alkanes
    Patent number: 9243198
    Abstract: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: January 26, 2016
    Assignee: Joule Unlimited Technologies, Inc.
    Inventors: Nikos Basil Reppas, Christian Perry Ridley
  • Fuel compositions
    Patent number: 9243199
    Abstract: A diesel fuel composition comprising a performance enhancing additive, wherein the performance enhancing additive is the product of a Mannich reaction between: (a) an aldehyde; (b) a polyamine; and (c) an optionally substituted phenol; wherein the polyamine component (b) includes the moiety R1R2NCHR3CHR4NR5R6 wherein each of R1, R2 R3, R4, R5 and R6 is independently selected from hydrogen, and an optionally substituted alkyl, alkenyl, alkynyl, aryl, alkylaryl or arylalkyl substituent.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: January 26, 2016
    Assignee: Innospec Limited
    Inventor: Jacqueline Reid
  • Method and apparatus for hydrogen sulphide removal
    Patent number: 9243200
    Abstract: A compact treatment apparatus and methodology is provided for scavenging at least H2S from an acid gas stream. The vessel is charged with a batch of an aqueous solution of H2S scavenging treatment liquid. Acid gas is discharged from a sparge bar fit with graduated openings, either graduated from small to large or from a few to many and spaced therealong, for distributed discharge into the treatment liquid. The acid gas percolates up through the liquid and into a vessel headspace, the gas being scrubbed of H2S for producing a treated discharge gas. The treatment solution can be an aqueous solution of incorporating one of several active H2S scavenger ingredients including amine-aldehyde compositions or triazines.
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: January 26, 2016
    Assignee: Almont Emissions Inc.
    Inventor: Bryan Campbell
  • Low viscosity lubricating oil base stocks and processes for preparing same
    Patent number: 9243201
    Abstract: A composition that includes one or more compounds represented by the formula R1(X)R2 wherein R1 is an alkyl group having from 4 to 40 carbon atoms, R2 is an aliphatic group having from 4 to 20 carbon atoms, an aromatic group having from 6 to 20 carbon atoms, or a cycloaliphatic group having from 5 to 20 carbon atoms, and X is a heteroatom. The composition has a viscosity (Kv100) from 2 to 30 at 100° C., a viscosity index (VI) from 100 to 200, and a Noack volatility of no greater than 20 percent. The disclosure also relates to a process for producing the composition, a lubricating oil base stock and lubricating oil containing the composition, and a method for improving one or more of solubility and dispersancy of polar additives in a lubricating oil by using as the lubricating oil a formulated oil containing the composition.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: January 26, 2016
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: Abhimanyu Onkar Patil, Shuji Luo, Satish Bodige
  • Lubricating composition containing a salt of a carboxylic acid
    Patent number: 9243202
    Abstract: The invention provides a lubricating composition containing an oil of lubricating viscosity and an amine or ammonia salt of a carboxylic acid compound where said carboxylic acid is characterized in that it is functionalized with a hydroxy-substituted aromatic moiety. The invention further relates to methods of lubricating an internal combustion engine by supplying the described lubricating composition to the internal combustion engine. The invention further relates to the use of the salt of the carboxylic acid compound as an antiwear agent or an antioxidant.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: January 26, 2016
    Assignee: The Lubrizol Corporation
    Inventors: Patrick E. Mosier, Scott Capitosti, Ewan E. Delbridge
  • Copolymers of polyaminopolyolefins and polyanhydrides and methods of their preparation
    Patent number: 9243203
    Abstract: Provided herein are copolymers of a polyaminopolymer and polyanhydride, wherein the polyaminopolymer comprises a polyaminopolyolefin; and methods of their preparation.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: January 26, 2016
    Assignee: Chevron Oronite Company LLC
    Inventors: Young Chang, Casey Stokes, David Morgan
  • Wear resistant lubricious composite
    Patent number: 9243204
    Abstract: A wear resistant lubricious composite includes a synthetic resin binder, a plurality of transfer film forming particles, and a plurality of hard nanoparticles. The hard nanoparticles are selected from the group consisting of metal oxides, metal carbides and metal nitride nanoparticles. A method of forming wear resistant lubricious composite articles includes the steps of providing a liquid phase synthetic resin precursor, adding a plurality of transfer film forming particles and a plurality of hard nanoparticles selected from the group consisting of metal oxide, metal carbide and metal nitride nanoparticles to the resin precursor to form a mixture, adding a hardener to the mixture, and curing the mixture.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: January 26, 2016
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Wallace Gregory Sawyer, Ben Peter Boesi, Nicole Lee McCook, David L. Burris
  • Refrigerator oil composition for carbon dioxide coolant
    Patent number: 9243205
    Abstract: Disclosed is a refrigerator oil composition for use with carbon dioxide refrigerant, characterized in that the composition dissolves in an amount of at least 0.1% by mass in a supercritical carbon dioxide at a temperature of 100° C. under a pressure of 15 Mpa. The invention provides a refrigerator oil composition for carbon dioxide refrigerant which composition is employed in a refrigerating system operated in a supercritical state of carbon dioxide refrigerant and, particularly, such a composition which can enhance heat-exchange efficiency during passage of supercritical carbon dioxide through a heat exchanger as well as which has excellent durability and lubrication performance.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: January 26, 2016
    Assignee: IDEMITSU KOSAN CO., LTD.
    Inventor: Masato Kaneko
  • Micro-spike algae harvesting and biofuel extraction system and method therefor
    Patent number: 9243206
    Abstract: A micro-spike algae harvesting and biofuel extraction system and method therefor whereby an algal solution is dispersed from a selected height onto an inclined micro-spike board which forms a substrate for supporting an array of upwardly-extending miniature spikes, wherein the miniature spikes puncture algae cells suspended in the solution to release biofuel contained therein.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: January 26, 2016
    Inventors: John Kelson, Benjamin J. Pavlik
  • Solvent extraction of products from algae
    Patent number: 9243207
    Abstract: Processes for extracting product molecules from an algae feed are provided. The algae feed represents an input stream, batch sample, or other algae portion suitable for use in product extraction. The product extraction is typically performed at pressures greater than ambient pressure. This allows for improved extraction, including the potential for use of extraction solvents at temperatures greater than the boiling point for the solvent.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: January 26, 2016
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: Peter Domaille, Joe Toporowski, Judit Bartalis, Paul J. Berlowitz, Paul D. Oldenburg
  • Blown corn stillage oil
    Patent number: 9243208
    Abstract: Blown corn stillage oils and methods for making blown corn stillage oils are disclosed. In one aspect the corn stillage oils are stripped to reduce the acid value of the resulting blown, stripped corn stillage oil. The method includes heating a corn stillage oil to a temperature of at least 90° C., and passing air through the heated oil to produce a blown corn stillage oil having a viscosity of at least 50 cSt at 40° C. In one aspect, the blown corn stillage oil is stripped to reduce the acid value of the blown, stripped corn stillage oil to 5 mg KOH/gram or less.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: January 26, 2016
    Assignee: CARGILL, INCORPORATED
    Inventors: Michael John Hora, Frank P. Lochel
  • Corn stillage oil derivatives
    Patent number: 9243209
    Abstract: Corn stillage oil derivatives having values for Gardner color of 10 or less and methods for making the corn stillage oil derivatives are disclosed. In one aspect, the corn stillage oil derivative comprises a heat bleached corn stillage oil. Preferably, the heat bleached corn stillage oil has a value for Gardner color of from 4 to 8. In another aspect, the corn stillage oil derivative comprises a blown corn stillage oil. Preferably, the blown corn stillage oil has a value for Gardner color of from 5 to 8.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: January 26, 2016
    Assignee: CARGILL, INCORPORATED
    Inventor: Frank P. Lochel
  • Violet leaves odorants
    Patent number: 9243210
    Abstract: A method of use, as a perfuming ingredient, of a compound of formula I in the form of any one of its stereoisomers or a mixture thereof, and wherein each R1 represents a hydrogen atom or a methyl group and at least one of said R1 is a hydrogen atom; R2 represents a linear or branched C3-8 alkyl group or unsaturated groups; and R3 represents a hydrogen atom or a methyl group. These compounds impart odor notes of the violet leaves type optionally together with green odor notes.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: January 26, 2016
    Assignee: Firmenich SA
    Inventor: Christian Chapuis
  • Separate collection and conversion method and plant for the reuse of natural and/or synthetic ester-based oils or greases of industrial origin for energy purposes
    Patent number: 9243211
    Abstract: Separate collection and conversion method and plant for the reuse of used oils and greases for energy purposes, which method provides one or more of the following steps: —producing and separating the waste from other substances or compounds, —collecting the waste—gathering/storing the waste in at least a collection and/or regeneration facility, —regenerating or treating the waste, —reusing the collected or regenerated or treated waste, an oil or a grease or a mixture containing at least a natural and/or synthetic ester-based oil and/or grease being considered as waste, which oil or grease or which mixture is the by-product or waste of industrial processes.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: January 26, 2016
    Assignee: A & A FRATELLI PARODI, S.p.A.
    Inventors: Augusto Parodi, Leandro Marini
  • Detergent formulation for textiles, comprising rhamnolipids with a predominant content of di-rhamnolipids
    Patent number: 9243212
    Abstract: The invention relates to detergent formulations for textiles, comprising rhamnolipids, where the content of di-rhamnolipids predominates, and to the use of certain rhamnolipid mixture compositions and of the aforementioned detergent formulations for increasing the rate of foam formation and/or for foam stabilization, and to the use of rhamnolipids for preventing the greying of a textile.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: January 26, 2016
    Assignee: EVONIK DEGUSSA GMBH
    Inventors: Dirk Kuppert, Ulrike Kottke, Juergen Lattich, Magdalena Volk, Hans Henning Wenk, Fabien Cabirol, Martin Schilling, Steffen Schaffer, Petra Allef
  • Fabric treatment composition comprising an aminosiloxane polymer nanoemulsion
    Patent number: 9243213
    Abstract: The present invention relates to amino silicone nanoemulsions. More specifically, the present invention relates to amino silicone nanoemulsions that may be used to protect surfaces from being soiled or wetted.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: January 26, 2016
    Assignee: The Procter & Gamble Company
    Inventors: Nicholas David Vetter, Mark Robert Sivik, Kristi Lynn Fliter, Patrick B Whiting, Harry W Broening, Corey James Kenneally
  • Cleaning composition having high self-adhesion and providing residual benefits
    Patent number: 9243214
    Abstract: A composition for treating a hard surface. The composition has: (a) at least one adhesion promoter; (b) at least one surfactant selected from the group consisting of: anionic, non-ionic, cationic, amphoteric, zwitterionic, and combinations thereof; (c) mineral oil; (d) water; (e) optionally, at least one solvent; and wherein the composition is self-adhering upon application to a surface to be treated, and wherein the composition provides a wet film to said surface when water passes over said composition and surface.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: January 26, 2016
    Assignee: S. C. Johnson & Son, Inc.
    Inventors: Michael E. Klinkhammer, Thomas A. Strash, John R. Wietfeldt, Russell B. Wortley
  • Benefit agent containing delivery particle
    Patent number: 9243215
    Abstract: The present invention relates to benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions. When employed in compositions, for example, cleaning or fabric care compositions, such particles increase the efficiency of benefit agent delivery, there by allowing reduced amounts of benefit agents to be employed. In addition to allowing the amount of benefit agent to be reduced, such particles allow a broad range of benefit agents to be employed.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: January 26, 2016
    Assignee: The Procter & Gamble Company
    Inventors: Jiten Odhavji Dihora, Ramanan Venkata Ganapathysundaram, Parshuram Gajanan Shukla, Arun Savalaram Jadhav
  • Use of a starch base copolymer in conjunction with a maleic polymer and a hydroxypolycarboxylic acid to control hardness under alkaline conditions
    Patent number: 9243216
    Abstract: The present invention includes methods and compositions control hard water in an alkaline environment. According to the invention, a unique combination of polymers has been developed which helps to completely control and eliminate hard water. The composition includes a maleic polymer, a hydroxypolycarboxylic acid, and a starch based polymer in a unique synergistic combination that can be used alone, or in combination with standard alkaline detergents in any cleaning regime (laundry, warewash, etc.) where hard water conditions exist.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: January 26, 2016
    Assignee: Ecolab USA, Inc.
    Inventor: Altony J. Miralles
  • Method of cleaning solar panels with a composition comprising an organic phosphoric acid or an organic phosphonic acid or salts thereof as sequestrant
    Patent number: 9243217
    Abstract: A method for cleaning the glass surface of solar panels which employs the use of highly efficient sequestering agents and allows to replace deionized water with municipal or fresh water of up to a very high water hardness, without having a loss in the long term power output of the solar panels.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: January 26, 2016
    Assignee: SAINT-GOBAIN CERAMICS & PLASTICS, INC.
    Inventors: Jason Alexander Sherlock, Douglas E. Ward
  • Dynamic multipurpose composition for the removal of photoresists and method for its use
    Patent number: 9243218
    Abstract: Methods for using improved stripper solutions having dimethyl sulfoxide; a quaternary ammonium hydroxide; an alkanolamine having at least two carbon atoms, at least one amino substituent and at least one hydroxyl substituent, with the amino and hydroxyl substituents being attached to two different carbon atoms; and a surfactant. Some formulation can additionally contain a secondary solvent. The stripper solutions are effective for removing photoresists from substrates, and typically have freezing points below about +15° C. and high loading capacities.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: January 26, 2016
    Assignee: Dynaloy, LLC
    Inventors: Michael T. Phenis, Lauri Kirby Kirkpatrick, Raymond Chan, Diane Marie Scheele, Kimberly Dona Pollard
  • System and method for producing algae
    Patent number: 9243219
    Abstract: A system and method of growing and harvesting algae provided whereby the system encompasses incubation tanks, internal lighting, chilled air diffusers, and an inline incubation tank for continuous batch processing. A centrifuge separates algae from growth media, and the media is processed through a series of reclamation steps so that cleaned water is reused for fresh media.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: January 26, 2016
    Inventor: Geronimos Dimitrelos
  • Bioreactor chamber
    Patent number: 9243220
    Abstract: Embodiments of the invention provide a chamber for a bioreactor, the chamber having a fluid inlet aperture and a fluid outlet aperture disposed at respective different locations of a wall of the chamber, with respect to a normal upright orientation of the chamber the chamber being provided with an upper wall portion defining an upper boundary of the chamber. The upper wall portion has an internal surface having a first portion that is vertically displaced with respect to a second portion. The internal surface of the upper wall portion is arranged to promote expulsion of trapped gas bubbles through the outlet aperture, the first and second portions of the upper wall portion each comprising a sloped portion.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: January 26, 2016
    Assignee: Kirkstall Limited
    Inventors: Arti Ahluwalia, Daniele Mazzei, Bruna Vinci, Giovanni Vozzi
  • Compositions and methods of functionally enhanced in vitro cell culture system
    Patent number: 9243221
    Abstract: Compositions and methods described herein provide a cell culture system in which cells are in high metabolic states from the onset of the culture. Combinations of various cell culture components disclosed and employed herein allow cells to be in high metabolic states useful for drug testing immediately after the start of cell culture.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: January 26, 2016
    Assignees: HUREL CORPORATION, THE GENERAL HOSPITAL CORPORATION
    Inventors: Martin Yarmush, Robert Freedman, Yaakov Nahmias, Eric Novik
  • Compositions and methods for pathogen transport
    Patent number: 9243222
    Abstract: This disclosure provides a method for transporting a pathogen under ambient conditions, by culturing the pathogen with an amoeba under conditions that favor the incorporation of the pathogen into a trophozoite, starving the amoeba until it encysts, then culturing under conditions that favor conversion of the amoeba back to a trophozoite. In one aspect, the conditions that favor incorporation of the pathogen into the cyst of the amoeba comprises contacting the pathogen with the amoeba in an iron rich environment. Virus and/or bacteria are pathogens that can be transported by the disclosed method. Amoeba that are useful in the disclosed methods include, without limitation Acanthamoeba castellanii, Hartmannella vermiformis and Naegleria gruberi.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: January 26, 2016
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Sahar El-Etr, George R. Farquar
  • High-density spot seeding for tissue model formation
    Patent number: 9243223
    Abstract: A model of tissue is produced by steps comprising seeding cells at a selected concentration on a support to form a cell spot, incubating the cells to allow the cells to partially attach, rinsing the cells to remove any cells that have not partially attached, adding culture medium to enable the cells to proliferate at a periphery of the cell spot and to differentiate toward a center of the cell spot, and further incubating the cells to form the tissue. The cells may be C2C12 cells or other subclones of the C2 cell line, H9c2(2-1) cells, L6 cells, L8 cells, QM7 cells, Sol8 cells, G-7 cells, G-8 cells, other myoblast cells, cells from other tissues, or stem cells. The selected concentration is in a range from about 1×105 cells/ml to about 1×106 cells/ml. The tissue formed may be a muscle tissue or other tissue depending on the cells seeded.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: January 26, 2016
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Michele L. Marquette, Marguerite A. Sognier
  • Cell culture medium
    Patent number: 9243224
    Abstract: A cell culture medium with high content of choline chloride is provided. The cell culture media further comprise only moderate amounts of amino acids, in particular the amount of glutamine in the cell culture media is limited. The cell culture media can be used for large scale production of polypeptides using cell cultures. The cell culture media with high content of choline chloride are particularly suitable for fed-batch cell culture whereby cell viabilities stay at a higher level for a longer time and high polypeptide titers although limited amounts of amino acids are used.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: January 26, 2016
    Assignee: Novartis AG
    Inventors: Wolfgang Ernst Gustav Budach, Helene C. Chassin, Kerstin Dorsch
  • Methods of obtaining cell populations enriched with desired cells
    Patent number: 9243225
    Abstract: Provided is a method including providing a population of cells including a target type of differentiated cells having a pre-identified cytoskeletal profile and at least one cell selected from undifferentiated cells, differentiating cells and differentiated cells being different from the target type of differentiated cells; and incubating the population of cells with a cytotoxic agent, in an amount and for a time period effective to form a modified population of cells including predominantly or consisting essentially of the target type of differentiated cells. The pre-identified cytoskeletal profile can include the presence of class III ?-tubulin on neuronal cells and the population of cells includes neural cells and neuronal cells.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: January 26, 2016
    Assignee: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED
    Inventors: Sharona Cohen Evenram, Benjamin Reubinoff
  • Biasing of cells toward retinal, corneal or lens development
    Patent number: 9243226
    Abstract: Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells or mesenchymal stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: January 26, 2016
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu Sugaya, Angel Alvarez
  • Cytotoxic T lymphocyte
    Patent number: 9243227
    Abstract: The present invention relates to a T lymphocyte having an activity to induce a T lymphocyte recognizing an antigen and a technique to use the T lymphocyte.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: January 26, 2016
    Assignees: Mie University, TAKARA BIO INC.
    Inventors: Hiroshi Shiku, Atsunori Hiasa, Satoshi Okumura, Hiroaki Naota, Yoshihiro Miyahara
  • Process for obtaining myofibroblasts
    Patent number: 9243228
    Abstract: The invention relates to a process for obtention of myofibroblasts. According to this process: (a) a sample of cells essentially comprising fibroblasts is prepared; and (b) this sample of cells is cultured in a serum-free culture medium. The main purpose addressed by the invention is to obtain a population of myofibroblasts, the characteristics whereof facilitate any study of these cells, and in particular as pure as possible a population of myofibroblasts. Some examples of application of the invention are: identification of biomarkers of myofibroblasts, identification of therapeutic targets, identification and validation of anticancer compounds, and an in vitro model for the screening of pharmaceutical or cosmetic compounds.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: January 26, 2016
    Assignee: Oncobiotek SA
    Inventors: Nicolas Jacques Rouyer, Robert Barthel
  • Synthetic surfaces for culturing stem cell derived cardiomyocytes
    Patent number: 9243229
    Abstract: Synthetic surfaces suitable for culturing stem cell derived cardiomyocytes contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many cases, are suitable for culturing stem cell derived cardiomyocytes in chemically defined media.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: January 26, 2016
    Assignee: Asterias Biotherapeutics, Inc.
    Inventors: Christopher Bankole Shogbon, Yue Zhou, Ralph Brandenberger
  • Construct for producing empty virus capsids
    Patent number: 9243230
    Abstract: The present invention provides a construct which, when expressed in a host cell, is capable of producing empty virus capsids, the construct comprising: (i) a nucleotide sequence encoding a capsid precursor protein; (ii) a nucleotide sequence encoding a protease capable of cleaving the capsid precursor protein; and (iii) a control element which controls the expression of the protease such that, when the construct is present in the host cell, the control element causes the protease to be expressed at a level sufficient to cleave the capsid precursor protein, but not sufficient to induce significant toxicity in the host cell. The invention also provides a vector and a host cell comprising such a construct and their use to generate empty virus capsids.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: January 26, 2016
    Assignee: THE PIRBRIGHT INSTITUTE
    Inventors: Bryan Charleston, Ian Jones
  • Mutant cytochrome P450 2B6 proteins and uses thereof
    Patent number: 9243231
    Abstract: The present invention to relates mutant human cytochrome P450 2B6 (CYP2B6) proteins, and fusion proteins comprising said mutant CYP2B6 proteins. In particular, fusion proteins comprising mutant CYP2B6 and NAPDH-cytochrome P450 reductase are provided. The invention also relates to methods of treatment of cancer and the use of said proteins and fusion proteins in the treatment of cancer, in particular via virus-directed enzyme prodrug therapy.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: January 26, 2016
    Assignee: Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle De Waziers, Walid Touati, Monique Diry, Jean-Pierre Flinois, Patrick Dansette, Philippe Beaune
  • Inhibitors of mitochondrial fission and methods of use thereof
    Patent number: 9243232
    Abstract: The present disclosure provides peptides and constructs that inhibit mitochondrial fission, and compositions comprising the peptides or constructs. The present disclosure provides methods of reducing abnormal mitochondrial fission in a cell. Also provided are methods for designing and validating mitochondrial fission inhibitor constructs and peptides, including but not limited to, evaluating the effects of the constructs and peptides on dynamin- 1-related protein (Drp1) GTPase activity, binding of Drp1 to mitochondrial fission 1 protein (Fis1), reduction of mitochondrial damage, reduction in cell death, inhibition of mitochondrial fragmentation in a cell under pathological conditions, and reduced loss of neurites in primary dopaminergic neurons in a Parkinsonism cell culture.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: January 26, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daria Mochly-Rosen, Xin Qi, Nir Qvit
  • Restriction endonucleases and their uses
    Patent number: 9243233
    Abstract: A restriction endonuclease with a recognition sequence 5?-TCGA-3?. The restriction endonuclease is sensitive to the presence of a modified cytosine residue in the recognition sequence. Methods and kits using the restriction endonuclease with a recongition sequence 5?-TCGA-3? are also disclosed.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: January 26, 2016
    Assignee: Thermo Fisher Scientific UAB
    Inventors: Renata Rim{hacek over (s)}elienė, Remigijus Skirgaila, Arvydas Lubys
  • Sequence-specific MRNA interferase and uses thereof
    Patent number: 9243234
    Abstract: The present invention provides an improved and specific mRNA interferase and related methods of protein-based mRNA interference.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: January 26, 2016
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Masayori Inouye, Yoshihiro Yamaguchi
  • Method of producing recombinant proteins with mannose-terminated N-glycans
    Patent number: 9243235
    Abstract: We describe a method of expressing a recombinant protein comprising mannose-terminated N-glycans from a host cell, the method comprising: (a) introducing a nucleic acid encoding a recombinant protein into a Chinese Hamster Ovary (CHO) cell comprising a mutation in the GnT 1 gene (GenBank Accession Number AF343963) leading to loss of GnT 1 function; and (c) expressing the recombinant protein from the host cell, in which the expressed recombinant protein comprises a mannose-terminated glycan structure, and in which the method does not include a step of introducing functional GnT-I into the host cell. The method may be used for producing recombinant glucocerebrosidase with a mannose-terminated glycan structure, suitable for treatment or prevention of Gaucher's Disease.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: January 26, 2016
    Assignee: Agency for Science, Technology and Research
    Inventor: Zhiwei Song
  • Glycosidase enzymes
    Patent number: 9243236
    Abstract: A thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organizms is disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the food processing industry, pharmaceutical industry and in the textile industry, detergent industry and in the baking industry.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: January 26, 2016
    Assignee: BP Corporation North America Inc.
    Inventors: Edward J. Bylina, Ronald V. Swanson, Eric J. Mathur, David E. Lam
  • Method for mass production of factor VII/VIIA
    Patent number: 9243237
    Abstract: A method for the mass production of human coagulation Factor VII. The method includes a) providing an expression vector carrying i) a dihydrofolate reductase promoter devoid of one or more CCGCC repeat sequences from the GC-rich region thereof and a dihydrofolate reductase (DHFR) gene operably linked thereto and ii) a cytomegalovirus (CMV) promoter and a human coagulation Factor VII gene operably linked thereto; b) obtaining a transformed host cell line containing the expression vector; and c) culturing the transfected host cell in the presence of a dihydrofolate reductase inhibitor to select cells which express human coagulation Factor VII with high efficiency; and d) adding sodium butyrate to the selected host cells.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: January 26, 2016
    Assignee: HANMI SCIENCE CO., LTD
    Inventors: Chang Hwan Kim, Sung Kap Hong, Byung Sun Lee, Sung Hwan Hong, Se Chang Kwon
  • Synthetic enzymes derived from computational design
    Patent number: 9243238
    Abstract: Disclosed herein are techniques for computationally designing enzymes. These techniques can be used to design variations of naturally occurring enzymes, as well as new enzymes having no natural counterparts. The techniques are based on first identifying functional reactive sites required to promote the desired reaction. Then, hashing algorithms are used to identify potential protein backbone structures (i.e., scaffolds) capable of supporting the required functional sites. These techniques were used to design 32 different protein sequences that exhibited aldol reaction catalytic function, 31 of which are defined in the Sequence Listing. Details of these 31 different synthetic aldolases are provided, including descriptions of how such synthetic aldolases can be differentiated from naturally occurring aldolases.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: January 26, 2016
    Assignee: University of Washington
    Inventors: David Baker, Alexandre Zanghellini, Lin Jiang, Andrew Wollacott, Daniela Grabs-Röthlisberger, Eric Althoff
  • Purification of cystathionine beta-synthase
    Patent number: 9243239
    Abstract: This invention provides chromatographic methods for the purification of a cystathionine ?-Synthase (CBS) protein, particularly truncated variants thereof and compositions and pharmaceutical compositions prepared therefrom.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 26, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Richard Carrillo, Jan P. Kraus, Tomas Majtan, David Naveh
  • Metabolically engineered for enhanced production of sialic acid
    Patent number: 9243240
    Abstract: A metabolically engineered E. coli strain which produces sialic acid and a method of making said strain. In the engineered E. coli cells, the nanT (sialic acid transporter) and nanA (sialic acid adolase) genes are inactivated, and the neuC and neuB genes of sialic acid biosynthesis in Neisseria meningitidis group B are introduced and overexpressed in the nanT? nanA? E. coli cell. In addition, the glucosamine synthase gene, glmS, of E. coli is co-overexpressed with neuB and neuC.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: January 26, 2016
    Assignee: Syracuse University
    Inventors: Christopher N. Boddy, Benjamin R. Lundgren
  • Separation and purification of nucleic acid from paraffin-containing samples
    Patent number: 9243241
    Abstract: Disclosed are rapid and reproducible methods for separating and purifying nucleic acids from paraffin-containing tissue samples. The disclosed methods involve a melting step, where paraffin-containing tissue samples are heated in the presence of a detergent, causing the paraffin to melt and tissue sample cells to lyse. From the resulting two-phase mixture (i.e., a paraffin phase and an aqueous phase), the aqueous phase is collected for purification of nucleic acid. Protease(s) can be used at one or more points in the separation process to facilitate tissue cell lysis and/or degrade proteins that could degrade nucleic acid or interfere with subsequent genetic manipulation or analysis.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: January 26, 2016
    Assignee: Life Technologies Corporation
    Inventors: Song-Hua Ke, Karl Hecker
  • Methods of making di-tagged DNA libraries from DNA or RNA using double-tagged oligonucleotides
    Patent number: 9243242
    Abstract: Disclosed are methods, compositions and kits related to making double-tagged DNA libraries from RNA/DNA samples. A double-tagged oligonucleotide (DTO) is employed to efficiently add two different tags to ends of DNAs to make a double-tagged DNA libraries. Also disclosed are methods to make mate pair libraries using the double-tagged oligonucleotide, and methods to make double-tagged single stranded DNA. The double-tagged DNA libraries of the invention are ready to be used on next generation sequencing machines.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: January 26, 2016
    Inventor: Yan Wang
  • Means and methods for detecting protein-peptide interactions
    Patent number: 9243243
    Abstract: A novel method of detecting and characterizing protein-peptide interactions is provided, which can be used for isolating peptides and proteins, respectively, as well as in drug screening and development.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: January 26, 2016
    Assignee: NEXIGEN GMBH
    Inventors: Hanjo Hennemann, Claudia Kruse, Sabine Hanke, Annette Friebe