Abstract: In an X-ray diagnostic apparatus of one embodiment, an image data generator sequentially generates X-ray images based on X-rays transmitted through a subject. An image processor executes: first processing where, in response to an instruction to start correction processing, a position of a target contained in a predetermined X-ray image is obtained as a reference position; and second processing where corrected images in which positions of the target are set at the reference position are sequentially generated from newly generated X-ray images. An image data storage unit stores therein information on a reference position with respect to each set of conditions of manipulation on the subject. Upon receiving the instruction to start correction processing, the image processor executes the second processing by using information on the reference position stored in the image data storage unit, in accordance with a set of the conditions of manipulation on the subject.

Abstract: A method for producing an attenuation-corrected time-gated PET image comprising includes obtaining a baseline MR image and a cine MR image of a structure; registering the baseline MR image to the cine MR image to create an image transform; and generating a corresponding cine ACF matrix using the image transform, and time-correlating the ACF matrix to a time-gated PET data set to produce an attenuation-corrected time-gated PET image.

Abstract: The present invention provides a radiographic imaging system, a radiographic imaging device, a handheld terminal device and a radiographic imaging method that may improve convenience for a user, in a case in which handheld terminal device is used for radiographic imaging. In a case where a radiographic image is imaged without using a console, the radiographic imaging device generates an image ID and transmits to the handheld terminal device. The handheld terminal device associates the received image ID with a patient ID and memorizes in a memory section. Meanwhile, the radiographic imaging device associates image data of the imaged radiographic image with the image ID and memorizes in a memory section. After imaging is completed, the console separately receives the associated image ID and patient ID from the handheld terminal device and receives the associated image ID and image data from the radiographic imaging device.

Abstract: An X-ray diagnostic apparatus of an embodiment includes an image generator, a detection unit, and an irradiation control unit. The image generator successively generates X-ray images based on X-rays emitted from an X-ray tube and transmitted through a subject. The detection unit detects a position of a predetermined target included in the successively generated X-ray images. The irradiation control unit identifies, based on the detected position of the predetermined target, a region in which the predetermined target can be visualized in the X-ray images, and performs control to reduce an X-ray irradiation dose to a region other than the identified region.

Abstract: A portable radiation imaging apparatus configured to wirelessly communicate with a radiation generation apparatus includes a radiation image sensor including a two-dimensional arrangement of a plurality of detection elements configured to detect a radiation generated by the radiation generation apparatus, a wireless communication unit configured to receive a generation condition of the radiation generated by the radiation generation apparatus, a storage unit configured to store the received generation condition and radiation image data obtained by the radiation image sensor in association with each other, and a housing configured to accommodate the radiation image sensor, the wireless communication unit, and the storage unit.

Abstract: A stethoscope according to exemplary embodiments of the inventive concept includes a chestpiece, a first connecting tube connected to the chest piece, ear pieces for a doctor connected to the first connecting tube for listening to the sound transmitted from the chestpiece, a sound collecting plate for transmitting the doctor's sound to a patient, a second connecting tube connected to the sound collecting plate, and ear pieces for a patient connected to the second connecting tube for transmitting the doctor's sound to the patient.

Abstract: Hemodynamic monitoring systems and methods are disclosed including a device comprising a first sensor configured to measure a velocity of blood flow in an adjacently-located portion of a superior vena cava of a mammalian patient using ultrasound waves; a second sensor configured to measure respiratory cycle data of the mammalian patient; and a computer configured to process the measured velocity of blood flow and the measured respiratory cycle data to provide hemodynamic parameters corresponding to the mammalian patient.

Abstract: There are described systems and methods of collecting ultrasound information related to a vascular graft condition of a patient and evaluation of the information using a virtual histology tree and hemodynamic information.

Abstract: A system is disclosed for determining a position and a change in the position of an anatomical structure. The system utilizes a surgical navigation system and a substrate that is capable of being removably mounted to an outer surface of a patient's body. The substrate includes a sensor that is tracked by the surgical navigation system and a positional device that determines the position of an anatomical structure relative to the sensor. The concatenation of the position of the sensor and the relative position of the anatomical structure allows a global position of the anatomical structure to be determined by a computer system and displayed to the user.

Abstract: Devices and methods for treating obesity are provided. More particularly, intragastric devices and methods of fabricating, deploying, inflating, locating, tracking, monitoring, deflating, and retrieving the same are provided.

Abstract: Solid-state ultrasound imaging devices, systems, and methods are provided. Some embodiments of the present disclosure are particularly directed to compact and efficient ultrasound transducer scanner formed from a substantially cylindrical semiconductor substrate. In some embodiments, an intravascular ultrasound (IVUS) device includes: an ultrasound scanner assembly disposed at a distal portion of the flexible elongate member, the ultrasound scanner assembly including a semiconductor substrate having a plurality of transistors formed thereupon. The semiconductor substrate is curved to have a substantially cylindrical form when the ultrasound scanner assembly is in a rolled form, and the plurality of transistors are arranged in a cylindrical arrangement when the ultrasound scanner assembly is in the rolled form.

Abstract: A method and system for generating an enhanced image of a volume of tissue, the method comprising: emitting acoustic waveforms toward the volume of tissue; detecting a set of acoustic signals derived from acoustic waveforms interacting with the volume of tissue; generating, from the set of acoustic signals, an initial model representing a distribution of an acoustomechanical parameter across a region of the volume of tissue; extracting a set of frequency components, from the set of acoustic signals; generating a first simulated wavefield with a first frequency component of the set of frequency components; generating an updated model of the initial model with the first simulated wavefield; iteratively refining the updated model with a set of simulated wavefields associated with the set of frequency components until a threshold condition is satisfied, thereby producing a final model; and generating the enhanced image from the final model of the volume of tissue.

Abstract: Apparatus for helmeting with carotid collars works in conjunction with a transcranial Doppler, phased array photoacoustic device to transmit a first energy to a region of interest at an internal site of a subject to produce an image and blood flow velocities of a region of interest by outputting an optical excitation energy to said region of interest and heating said region, causing a transient thermoelastic expansion and produce a wideband ultrasonic emission. Systems integrate and register the signals for use in, for example, acute stroke care.

Abstract: A medical imaging system according to embodiment includes an ultrasonic probe, positioning circuitry, first mapping relationship estimation circuitry, repositioning circuitry and a display. The first mapping relationship estimation circuitry estimates a first mapping relationship between a position of the ultrasonic probe when a subject is in a first position state and a position of the ultrasonic probe when the subject is in a second position state. The repositioning circuitry determines a target position of a volume image corresponding to the position of the ultrasonic probe in the second position state according to the first mapping relationship and a second mapping relationship between the position of the ultrasonic probe in the first position state and the target position of the volume image of the subject. The display displays the image of the target position obtained from the volume image according to the target position of the volume image.

Abstract: Ultrasonic diagnostic devices and methods for supporting synchronous scanning are provided in this disclosure. The ultrasonic diagnostic device can include a display module, an imaging system and multiple probes. The multiple probes are capable of being attached to different positions on a body surface of a patient, such that synchronous and real-time scanning can be performed by the multiple probes for body parts corresponding to those different positions on the patient's body surface. Echo signals can be obtained by the multiple probes through scanning, and may then be transmitted to the imaging system. The imaging system can convert the multiple echo signals transmitted from the multiple probes into multiple ultrasonic images. The display module may be coupled to the imaging system. It can receive the multiple ultrasonic images processed and outputted by the imaging system, and display these images synchronously.

Abstract: An ultrasonic device includes a first element row in which ultrasonic transducer elements are arranged at line-symmetrical positions along a first straight line, where a second straight line orthogonal to the first straight line is the axis of symmetry, and are connected to a first interconnect, and a second element row in which ultrasonic transducer elements are arranged at line-symmetrical positions adjacent to the first element row, where the second straight line is the axis of symmetry, and are connected to a second interconnect. When the distance between a k-th element included in the first element row and a k-th element included in the second element row is represented by Dk, a relationship Dk<Dk+1 is satisfied with respect to at least one value of “k”.

Abstract: An ultrasound system may include a curved probe having a first set of elements that define a first aperture, and a second set of elements that define a second aperture. The probe may be configured to simultaneously transmit first and second ultrasound signals from the first and second apertures, respectively. The first ultrasound signal is configured to be transmitted in a first direction that is parallel with a first beam axis of the first ultrasound signal. The second ultrasound signal is configured to be transmitted in a second direction that is parallel with a second beam axis of the second ultrasound signal. At least one processor is configured to independently steer each of the first and second ultrasound signals.

Abstract: [Object] To provide a characteristic-value calculating device, a characteristic-value calculating method, and a recording medium that can extract a characteristic value for more accurately recognizing the state of a moving object, such as a human, from a Doppler signal. [Solution] A characteristic-value calculating device includes an acquiring unit that acquires a Doppler signal, an extracting unit that extracts a time-series signal constituted of a predetermined frequency component from the Doppler signal acquired by the acquiring unit, a selecting unit that selects a signal value at a predetermined interval from the time-series signal extracted by the extracting unit, and a calculating unit that calculates higher-order local autocorrelation based on the signal value selected by the selecting unit.

Abstract: An ultrasonic diagnostic device and ultrasonic three-dimensional image generation method generate a three-dimensional image by expressing interaction by dispersion, absorption, or the like of light in tissue or between tissues. The ultrasonic diagnostic device displays a three-dimensional image of a target object based on at least one piece of volume data among luminance volume data, blood flow volume data, and elasticity volume data.

Abstract: A system and a method of medical imaging includes registering an ultrasound image to a non-ultrasound image according to a first transformation. The system and method includes registering the non-ultrasound image to the x-ray image according to a second transformation. The system and method includes registering the ultrasound image to the x-ray image based on the first transformation and the second transformation and co-displaying ultrasound information registered to the x-ray image. The ultrasound information is based on the ultrasound data.

Abstract: A method of diagnosing the occurrence or non-occurrence of a blood vessel blockage or hemorrhage comprises non-invasively applying ultrasound to a location on a patient's body, where the ultrasound is applied in an alternating and pulsed fashion, administering acoustic amplifiers to the patient, monitoring a feedback acoustic response signal of the acoustic amplifiers triggered by the ultrasound, and determining a diagnosis based at least in part on a relationship between an acoustic response signature of the acoustic response signal and a baseline acoustic response signature.

Abstract: Devices, systems, and methods for detecting estrus in subjects are provided. Devices include a housing configured for intravaginal/intrauterine deployment and retention and a sensor disposed in or on the housing, and are configured to use condition information sensed by the sensor to determine an estrus condition of the subject. Methods include deploying a device in the subject, sensing the condition information, and determining an estrus condition using the condition information. Systems include a device configured to communicate with a base station and/or with other implanted devices, which are located within a reception radius thereof, regarding the determined estrus condition.

Abstract: Methods of detecting and predicting ovulation and a period of fertility include determining a series of measures indicative of the basal body temperature of a female human user to identify a temperature change event. The method includes obtaining, within a first 24 hour period, a plurality of first readings of the temperature of the female human user at intervals over a first extended period of at least an hour. The plurality of first readings are then processed to determine at least one first representative temperature reading representative of the basal body temperature of the user for the first extended period and the at least one first representative temperature reading is stored. The method is repeated for at least second and third 24 hour periods and the representative temperature readings are provided for analysis to identify a temperature change event for the female human user.

Abstract: A sweat collection device includes an elongate concave sweat-collecting surface at a face thereof for placement over an iontophoresis-stimulated area of a patient's skin to collect sweat and pass it through an axial bore in the concavity. A length of flexible tubing is secured to the axial bore for receiving and storing the collected sweat. A chamber may be provided for holding the tubing in flat coiled condition. Collected sweat builds up within the tubing from the axial bore. The device can include markings to indicate when a minimum amount of sweat has been collected in the tubing and can indicated a range for collected sweat that takes into account variations in the tubing. An open end of the tubing can be flared for easy insertion of a blunt needle to extract sweat or a guide passage can guide insertion of the needle into the open end of the tubing.

Abstract: A needle assembly according to an exemplary aspect of the present disclosure includes, among other things, a cannula, a trocar insertable through the cannula, the trocar including a shaft extending longitudinally between a proximal portion and a tip portion and a groove formed in the shaft and extending from near the tip portion at least partially toward the proximal portion.

Abstract: The present disclosure provides a biopsy needle configured to maximize tissue sampling yield and further ensure collection of a cohesive unit of sampled tissue. The biopsy needle of the present disclosure provides a distinct cutting slot defined on one side of a distal portion of the needle. The side cutting slot is configured to collect a full core of tissue sample and keep the full core intact.

Abstract: The present disclosure provides biopsy needles configured to maximize tissue sampling yield and further ensure collection of a cohesive unit of sampled tissue. The biopsy needles of the present disclosure provide a distinct tissue collection distal end configured to collect a full core of tissue sample and keep the full core intact. The distal end may include a distinct helical slot extending from an open distal end or a distinct cutting tip forming a coring feature.

Abstract: The present disclosure provides a device for needle biopsy having a novel delivery handle system for interchangeably delivering a needle to a biopsy site. The delivery handle system is adjustable in length and includes a proximal handle member slideably disposed over a middle handle member, and the middle handle member is slideably disposed over a distal handle member. The proximal handle member includes an inner hub housing component configured to interchangeably receive a needle subassembly that can be inserted into and withdrawn from the proximal handle member. The needle subassembly includes a needle having a distinct tissue collection distal end configured to collect a full core of tissue sample and keep the full core intact. The needle subassembly further includes a needle protector subassembly including a needle protection hub configured to receive the distal end of a needle.

Abstract: The present disclosure generally relates to a biopsy needle configured to maximize tissue sampling yield and collect a cohesive unit of sampled tissue. The biopsy needle includes an elongate tubular body comprising a lumen extending therethrough from a proximal open end to a distal open end of the body. The distal end includes first and second tip portions extending therefrom and radially opposing one another. The first tip portion has a length greater than the second tip portion, thereby resulting in an increased surface area of a curvilinear cutting edge extending from the first tip portion to the second tip portion. Additionally, each of the first and second tip portions defines a point configured to pierce the tissue to be sampled and further direct tissue towards the lumen of the body to be excised by the cutting edge upon contact therewith.

Abstract: The present disclosure provides an adjustable delivery handle system for interchangeably delivering a needle to a biopsy site. The adjustable delivery handle system includes a delivery handle having an inner hub housing component configured to interchangeably receive a needle subassembly that can be inserted into and withdrawn from the proximal handle member. The needle subassembly includes a biopsy needle having a distinct tissue collection distal end configured to maximize tissue sampling yield and collect a cohesive unit of sampled tissue. The distal end of the needle includes first and second tip portions extending therefrom and radially opposing one another. The first tip portion has a length greater than the second tip portion, thereby resulting in an increased surface area of a curvilinear cutting edge extending from the first tip portion to the second tip portion.

Abstract: A device for collecting a tissue sample includes Needle and Stylet. Needle is extending longitudinally from a proximal to a distal end and includes a lumen extending therethrough. Stylet is movably housed in the lumen and extending along a longitudinal axis from a proximal to a distal end and includes a scooper at the distal end thereof. The scooper is connected to a proximal portion of Stylet via a hinge biased toward a bent position in which the scooper is bent away from the longitudinal axis. Stylet is movable between a constrained configuration and a tissue-collecting configuration. The scooper includes a channel extending longitudinally therethrough and a window extending laterally through a wall thereof in communication with the channel to collect a tissue sample therethrough as Stylet is moved from the tissue-collecting to the constrained.

Abstract: Sample Collection Apparatus A sample collection apparatus is disclosed. The sample collection apparatus comprises an elongate outer casing having an insertion end and a withdrawal end. The sample collection apparatus further comprises a sample collection device within the outer casing. The apparatus is moveable between an undeployed configuration in which the insertion end is closed and a deployed configuration in which the insertion end is open wherein the sample collection device is extendable through the insertion end of the outer casing in the deployed configuration.

Abstract: A system further comprises a processing unit functionally associated with the display, wherein the processing unit comprises an image processing module. The system further comprises a camera functionally associated with the processing unit via a communication channel for transferring images from the camera to the processing unit and configured to obtain images of a biopsy sample obtained from the body of the patient. The processing unit is configured to receive image data from an imaging modality capable of obtaining images of internal patient's body parts not directly visible from outside the body, and to display to a user on a display images related to the image data. The processing unit is further configured to generate, from at least one image of a biopsy sample and using the image processing module, a processed image related to the biopsy sample, and to display the processed image on the display.

Abstract: An interventional optical molecular imaging system and method are provided for use with a biopsy introducer needle. The system includes an imaging tool configured to slide coaxially through the biopsy introducer needle toward a tip of the biopsy introducer needle. The system also includes a laser illumination source coupled to the imaging tool, a camera configured to capture images from the imaging tool, and a computer coupled to the camera and the laser illumination source. The computer includes a processor configured to activate the laser illumination source to emit light through a tip of the imaging tool, collect imaging data from the camera after activating the laser illumination source, analyze the imaging data to determine a fluorescence measurement at the tip of the imaging tool, and display an indication of the fluorescence measurement.

Abstract: A method of treating a varicose vein involves inserting the distal portion of an intraluminal device into a varicose vein, wherein the device includes an elongated outer sheath and an expandable expansion member at the distal end of the outer sheath. The method also involves relatively moving the distal and proximal ends of the expandable spiral expansion member to reduce the distance between the distal and proximal ends of the expansion member and cause the expansion member positioned inside the varicose vein to outwardly expand to an expanded expansion member comprising a plurality of contact members in contact with the inner wall of the varicose vein. The method further includes axially moving the expanded expansion member while the contact members are in contact with the inner wall of the varicose vein and rotating the expanded expansion member during the axial movement.

Abstract: A surgical delivery instrument for delivering a vascular hole closure device having first and second flexible members and a first and second engagement members extending from the respective flexible member. The delivery instrument includes a housing having first and second longitudinally extending openings and first and second projecting surfaces, the first projecting surface extending into the first opening for engagement by the first engagement member and the second projecting surface extending into the second opening for engagement by the second engagement member. The first engagement member is held by the first projecting surface until a predetermined force is applied to the first engagement member during placement of the closure device at a target site.

Abstract: A method and apparatus for closing a vascular wound includes an apparatus that can be threaded over a guidewire into place at or adjacent the wound. The apparatus includes a chamber that encloses a hemostatic material therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. A blocking member distal of the hemostatic material functions as a barrier to prevent the hemostatic material from entering the wound. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.

Abstract: Embodiments described herein provide devices, systems, and methods that reduce the distance between two locations in tissue, often for treatment of congestive heart failure. For example, an anchor of an implant system may, when the implant system is fully deployed, reside within the right ventricle in engagement with the ventricular septum. The anchor may be deployed into the heart through a working lumen of a minimally invasive access tool. The minimally invasive access tool may have a plurality of grippers near a distal end of the working lumen. The grippers may engage epicardial tissue of the heart and may be moved radially inwardly relative so as to provide stabilization of the epicardial tissue and/or hemostasis near an access site where the anchor is inserted through the epicardium. The minimally invasive access tool may minimize blood loss from the access site and improve anchor implant processes.

Abstract: Aspects of the invention relate to an applicator which can house multiple components of a formulation in separate receptacles. In certain embodiments, an applicator of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues.

Abstract: An orthopaedic joint distractor includes a stem post defining a pivoting axis, an actuator configured to cause translational movement of the stem post, a locking sleeve holding the actuator and the stem post, a distractor arc held by the locking sleeve orthogonally to the pivoting axis and having a surface, and a first locking member held by the locking sleeve that can be advanced away from and toward the surface. The first locking member prevents rotation of the distractor arc about the pivoting axis when it has advanced a sufficient distance toward the surface.

Abstract: Disclosed herein are methods and devices for distracting adjacent vertebrae during surgical procedures for implanting spinal prostheses. In an exemplary embodiment, a distractor is disclosed that maintains the empty space between adjacent vertebrae following a discectomy, and that can removably mate with other surgical instruments, such as, for example, a filler bar, an implanting tool, or a funnel. In other embodiments of the present invention a distractor is disclosed having various features to assist in implanting a spinal prosthesis, such as, for example, an angled distal end and/or an expandable paddle. In another embodiment of the present invention, an articulating inserter is disclosed. Moreover, various implants and funnels are also disclosed herein.

Abstract: A surgical retractor includes a retractor body and a retractor arm. The retractor arm includes a first portion configured to operatively connect to the retractor body, and a control assembly configured to control movement of a retractor blade. The control assembly includes a base member having a first opening and a second opening, and movable between a first position and second position. The retractor arm further includes a regulating member to control rotation of the base member and move through the first opening of the base member, a connecting member cooperatively connected to the regulating member, and a barrel member in operative slidable engagement with the second opening formed in the base member.

Abstract: A surgical device for stabilizing or immobilizing moved tissue or for positioning organs, especially a part of a beating heart, includes a flexible arm, especially a link arm, fixed or fixable to a base member which arm can be brought into different positions and/or attitudes and at the free end of which at least one retaining element is arranged, and comprising a tightening mechanism by which the arm can be fixed at a desired position. The tightening mechanism is tightened and/or released by means of a manually controllable external power source.

Abstract: Herein described are suture-anchoring implanted medical devices formed from a bioresorbable metal alloy that may be used to secure soft tissue to bone. The metallic bioresorbable tissue anchoring devices of the present invention are optimally configured such that all portions of the device are resorbed over a short predetermined period of time while maintaining their tissue anchoring capability and preventing the generation of loose foreign bodies therefrom.

Abstract: A method for attaching an elongated object to bone, the method comprising: forming a hole in the bone; positioning a loop of the elongated object in the hole; advancing a surgical wire into the bone so that the surgical wire is directed toward a location within the interior of the loop; and severing the surgical wire intermediate its length so as to create a distal portion and a remainder portion and, if the distal portion of the surgical wire does not extend through the loop, further advancing the distal portion of the surgical wire so that it extends through the loop.

Abstract: Apparatus for securing a first object to a second object, the apparatus comprising: an anchor, the anchor comprising: an elongated body having a distal end, a proximal end, and a lumen extending between the distal end and the proximal end, the lumen comprising a distal section and a proximal section, the distal section of the lumen having a wider diameter than the proximal section of the lumen; a window extending through the side wall of the elongated body and communicating with the lumen, the window being disposed in the vicinity of the intersection between the distal section of the lumen and the proximal section of the lumen and being sized to receive a first object therein; an elongated element extending through the lumen of the elongated body, the elongated element comprising a proximal end and a distal end; and a locking element mounted to the distal end of the elongated element and disposed in the distal section of the lumen; whereby, when the elongated body is disposed in a second object, and a first o

Abstract: An adjustable, knotless button/loop construct for fixation of ankle syndesmosis tibio-fibular diastasis and an associated method of ankle repair using the same. The knotless construct comprises a pair of buttons attached to a flexible, continuous, self-cinching, adjustable loop integrated with two splices that are interconnected. The knotless construct is passed through fibular and tibia tunnels and the buttons are secured on the cortical surfaces of tibia and fibula. One of the buttons (for example, an oblong button) is secured on the medial side of the tibia by passing the button and the flexible, adjustable loop though the fibular and tibia tunnels and then flipping and seating the button outside the tibia. The length of the flexible adjustable loop is adjusted so that the second button (for example, a round button) is appropriately secured on the lateral fibula.

Abstract: Improved medical suturing devices, systems, and methods for loading a needle in a suturing device, particularly standard surgical needles. An exemplary device includes a body having one or more clamps for grasping a needle and a needle loader supporting the needle in a delivery position suitable for advancing through a minimally invasive aperture and a needle loading position suitable for grasping with a clamp of the device. Preferably, the needle loader includes an elongate body having a rotatable needle holding member and is releasably coupleable with the device body such that the needle is moveable between positions from a proximal portion of the device. Methods includes selecting a standard surgical needle, advancing the needle loader device into a body of a patient, and moving the needle to a needle loading position for grasping and suturing with one or more clamps of the device.

Abstract: A suture assembly includes a suture clip connected to a suture. The suture clip includes a proximal end opposite a distal end, a first side edge opposite a second side edge, with each of the first side edge and the second side edge extending from the proximal end to the distal end of the suture clip. The suture clip is formed such that the first side edge is spaced apart from the second side edge to provide an open slot that is adapted to allow the suture clip to flex in a radial direction. A tab extends from the distal end of the suture clip and is crimped to the suture. A rib formed on an interior surface of the suture clip.

Abstract: A surgical instrument includes a handle assembly having a trigger operable to fire a staple driver to staple tissue. The instrument includes a pointed rod to which an anvil may be coupled. An anvil detection feature is included to determine when the anvil is coupled to the rod. In some versions, the anvil detection feature comprises a translatable rod that inhibits a lockout feature from disengaging. In other versions, an anvil sensing tube is disposed about the pointed rod and interferes with actuation of the trigger in a first position. A recess in the tube permits trigger to actuate when the anvil sensing tube is in the second position. Alternatively, a resilient tab is coupled to the pointed rod and resists actuation of the staple driver. A trigger lockout assembly may include a spring-loaded button that “pops” out when a push rod is actuated, thereby freeing a pivotable lockout feature.