Abstract: A microscope system includes: a wavefront modulator that modulates a wavefront of light from a light source; an objective that irradiates a sample with light whose wavefront has been modulated by the wavefront modulator; a spherical aberration corrector that corrects spherical aberration caused by a difference between a refractive index of a medium between the objective and the sample and a refractive index of the sample; a refractive index calculator that calculates, for each wavelength of the light from the light source, an average refractive index of a medium between the objective and a condensing position of light emitted from the objective on the basis of an amount of the corrected spherical aberration; and a controller that controls the wavefront modulator to correct chromatic aberration calculated on the basis of the calculated average refractive index for each wavelength.

Abstract: A fluorometer for measuring fluorescence of a sample includes an excitation source for emitting electromagnetic radiation along a first beam path to induce fluorescence in the sample. An excitation filter transmits electromagnetic radiation from the excitation source toward the sample. An excitation filter holder supports the excitation filter and defines an aperture for passage of electromagnetic radiation from the excitation source. The aperture is positioned asymmetrically relative to the first beam path such that the aperture allows an asymmetrical portion of the electromagnetic radiation in the first beam path to pass toward the sample and the excitation filter holder blocks passage of a corresponding asymmetrical portion of the electromagnetic radiation in the first beam path.

Abstract: This invention provides compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided.

Abstract: Disclosed are systems and methods for analyzing an oil/gas separation process. One disclosed system includes a flow path containing a fluid, a fluid separator coupled to the flow path and having an inlet for receiving the fluid and a discharge conduit for discharging the fluid after having undergone a separation process in the fluid separator, an optical computing device having an integrated computational element configured to optically interact with the fluid before the fluid enters the fluid separator and after the fluid exits the fluid separator and thereby generate optically interacted light, and at least one detector arranged to receive the optically interacted light and generate an output signal corresponding to a characteristic of the fluid.

Abstract: Photo-aging monitoring of light-based chemical indicators that experience performance degradation as the cumulative amount of light exposure from measurement and/or reference illumination increases from usage. Differing regions on a chemical indicator are illuminated with measurement illumination light of differing exposures, for example, higher brightness, longer exposure times, or both. Readings from the differing regions are compared with known aging information for the chemical indicator at issue to determine a confidence factor for the measurements. The confidence factor can be used to control various actions relating to measurements acquired from the chemical indicators, such as compensating measurement readings for photo-aging, assigning confidence levels to measurement readings, and issuing alerts to users when photo-aging exceeds one or more predetermined thresholds.

Abstract: A visual inspection apparatus 10 performing a visual inspection of an electronic component 13 including opposing sides 11, 11a and opposing sides 12, 12a, the apparatus 10 including an optical-path adjusting means 30 changing a traveling direction of a light and setting an appearance of the side 11a of the electronic component 13 temporarily stopped at a first inspection point in an image of the side 11 of the electronic component 13 captured by a first imaging means 31, and an optical-path adjusting means 34 setting an appearance of the side 12a of the electronic component 13 temporarily stopped at a second inspection point in an image of the side 12 of the electronic component 13 captured by a second imaging means 35, thereby performing a visual inspection of the sides 11, 11a, 12, 12a.

Abstract: Provided are photoluminescence spectroscopy systems and methods for identifying and quantifying impurities in a semiconductor sample. In some embodiments, the systems and methods comprise a defocused collimated laser beam illuminating a first sample surface, and collection by a collection lens of photoluminescence from a sample edge at the intersection of the first surface with a substantially orthogonal second surface, wherein the first sample surface is oriented from about 0° to 90° with respect to a position parallel to the collection lens.

Abstract: An optical system is effective to illuminate and scan an interior wall of an object having an interior bore, such as a stent. The system includes a light source, an object support having a light conducting portion, an image taking lens, and a line scan camera. The interior bore and the light conducting portion of the object support are in axial alignment with a center optical axis of the image taking lens. A drive mechanism engages the object without impacting the axial alignment. Various aspect of this optical system include a rotating wheel or transparent plate as the drive mechanism. The object support may be an opaque rod having a light conducting portion or a transparent rod.

Abstract: A device for determining a composition of a fuel mixture is provided, in particular for determining an ethanol component and/or a water component in the fuel mixture. The device includes at least one housing having at least one electrically conductive housing element through which the fuel mixture is able to flow. At least one internal conductor, which is at least partially enclosed by the housing element, is introduced into the housing element. In addition, the device has at least one connection device for the coupling of microwave signals.

Abstract: A system and method include acquisition of projection data from a scanned object, the set of projection data comprising a plurality of projection measurements. The system and method also include calculation of a set of modified statistical weights from the projection data, wherein a respective modified statistical weight of the set of modified statistical weights comprises a deviation from an inverse variance of a corresponding projection measurement of the projection data. The system and method further include reconstruction of an image of the scanned object using the set of modified statistical weights as coefficients in an iterative reconstruction algorithm.

Abstract: Disclosed herein are representative embodiments of methods, apparatus, and systems for performing combined neutron and gamma ray radiography. For example, one exemplary system comprises: a neutron source; a set of alpha particle detectors configured to detect alpha particles associated with neutrons generated by the neutron source; neutron detectors positioned to detect at least some of the neutrons generated by the neutron source; a gamma ray source; a set of verification gamma ray detectors configured to detect verification gamma rays associated with gamma rays generated by the gamma ray source; a set of gamma ray detectors configured to detect gamma rays generated by the gamma ray source; and an interrogation region located between the neutron source, the gamma ray source, the neutron detectors, and the gamma ray detectors.

Abstract: Various embodiments of systems, components, modules, routines, and processes for luminescence based spectral measurement are described herein. In one embodiment, a method for measuring a scintillation property of a sample includes directing an ionizing radiation toward the sample, thereby inducing the sample to produce an emission. The method also includes acquiring a spectral luminescence of the produced emission by the sample, the spectral luminescence including a plurality of luminescence intensities at corresponding emission wavelengths or frequencies. The scintillation property of the sample may then be determined based on the acquired spectral luminescence.

Abstract: High precision elemental concentration determination is achieved using a nuclear magnetic resonance device that can continuously monitor samples of a source fluid in the field and in the refinery plant while the source fluid is refined into a desired product fluid.

Abstract: A device for monitoring a urea solution in a tank of a motor vehicle tank includes a light source capable of emitting a light beam, a photodetector capable of detecting a portion of a light beam emitted by the light source, and a part made of a material allowing the propagation of a light beam emitted by the light source. The part includes a surface intended to be in contact with the urea solution. The light source, the photodetector, and the part are arranged in such a way that a light beam emitted by the light source is propagated by the surface of the part, by refraction, toward the photodetector. A tank including such a monitoring device is provided. A process for monitoring a urea solution in a tank of a motor vehicle is also provided.

Abstract: A specified gas concentration sensor includes a thin film thermally separated from a substrate, which is provided by a heater, a temperature sensor and an absorbing substance of a specified gas, and temperature change accompanied by heat generation while absorbing the specified gas in an ambient gas being capable of measuring by the temperature sensor. The absorbed specified gas is released from the absorbing substance by heating with the heater, and after stopping heating with the heater, the specified gas concentration in the ambient gas is obtained by utilizing an output of the temperature sensor at a time passing a predetermined time which is a thermal time constant of the thin film or longer at which the specified gas is absent from the heater. An optional heat conductive type sensor having no absorbing substance of the specified gas can broaden the measurable range of the specified gas concentration.

Abstract: Non-destructive testing system performs accurate testing as to whether lamination joining portion of different metal materials is in strong joining state by secure metal joining. The system sets a lamination joining portion of different metal materials of a work to a certain position and angle. Laser light in certain waveform is applied to lamination joining portion surface to capture images by infrared camera, and data processing device obtains infrared images. Based on infrared images, Fourier transform is performed on each pixel of infrared images, and phase image is created by console device. Based on created phase image, effectiveness/defectiveness of joining is determined. In this non-destructive testing, whether reflection by vertical wall in vicinity is significant is determined, based on intensity of infrared images obtained immediately after irradiation with laser and angle between laser light optical axis and testing part surface is finely adjusted to obtain infrared images with less noise.

Abstract: A method for analyzing a sample includes providing a sensor assembly having a sensing region with a plurality of resonant circuits, and a plurality of tuning elements. The method further includes exposing the sensor assembly to an environment comprising the sample, and probing the sample with one or more frequencies generated by the sensor assembly. Furthermore, the method includes determining an impedance of a sensor response over a measured spectral frequency range of the sensor assembly, and relating measurement of impedance of the sensor assembly to at least one environmental property of the sample.

Abstract: Foreign metal inspection equipment is provided with: a conveying device for conveying a sample to be subjected to inspection; electrodes positioned so as to face the surface of the sample; a measurement device for measuring the capacitance between the electrodes and the sample being conveyed by the conveying device; and a processing unit that inspects for foreign metal mixed in the sample on the basis of the change in capacitance measured by the measurement device.

Abstract: Methods and apparatus are provided for manufacturing an analyte detecting device. In one embodiment, the method comprises providing a substrate, applying a plurality of layer of materials on said substrate; applying a layer containing at least one mediator; and screen printing a hydrogel on the layer.

Abstract: Various embodiments that allow for determination of hematocrit by a time differential between the input and output signals such that a glucose measurement for a blood sample can be corrected by the measured hematocrit of the blood sample.

Abstract: Described are methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that is simpler, less error prone and provides the unexpected advantage of being insensitive to hematocrits in the blood sample.

Abstract: An electrochemical test sensor being adapted to assist in determining information relating to an analyte in a fluid sample and includes a base and a second layer. The base includes a plurality of electrodes, a working conductive lead and a counter conductive lead thereon. The electrodes include a working electrode and a counter electrode. The second layer assists in forming a channel in which the channel includes a reagent therein. Auto-calibration information of the test sensor is performed by a plurality of auto-calibration segments connected to one of the following: the working conductive lead, the counter conductive lead, or neither of the conductive leads, at least one of the plurality of auto-calibration segments being connected to the working conductive lead and at least one of the plurality of auto-calibration segments being connected to the counter conductive lead.

Abstract: A terminal connection portion has a plate shape extending in an axial direction and has a constant width dimension. A terminal front end edge thereof has a convex shape at a front end side in the axial direction and has a circular-arc shape with a radius from 0.5 times to 0.8 times the width dimension, and is arranged in the center between a first pad side edge and a second pad side edge, on an electrode pad. A brazing material portion has a form spreading to a front end side in the axial direction away from the terminal connection portion. A brazing material front end edge which is a front end edge of the brazing material portion has a convex and circular-arc shape at the front end side in the axial direction, and is configured to be apart from a pad front end edge.

Abstract: A system including a nitrogen oxide sensor and a controller is provided. The nitrogen oxide sensor is configured to generate a first signal indicative of nitrogen oxides content in an exhaust gas. The controller is communicably coupled to the nitrogen oxide sensor. The controller configured to receive the first signal indicative of nitrogen oxides content in the exhaust gas. The controller is also configured to receive a second signal corresponding to an operational parameter of a power source. Further, the controller is configured to compare a derivative of the first signal with a derivative of the second signal. The controller is configured to trigger an error counter when an absolute value of the compared derivative crosses a predetermined threshold. Thereafter, the controller is configured to determine a condition of the nitrogen oxide sensor based on a count of the error counter in a predetermined period of time.

Abstract: Methods of detecting the presence of toxins in a sample using electrophoretic separations and of performing electrophoretic separation of complex samples are provided. The method of detecting the presence of toxins includes reacting a sample and a substrate with a signaling enzyme which converts the substrate to the product in a reaction medium, introducing a run buffer into a separation channel having an inlet end, selectively introducing at least one of the substrate and the product of the reaction medium into the inlet end of the separation channel, electrophoretically separating the substrate and the product, and determining the rate of conversion of the substrate to the product, wherein a change in the rate of conversion is indicative of the presence of toxins.

Abstract: An acoustic wave detector includes: a transducer; and a light reflecting member which is positioned between the transducer and a subject surface that is irradiated with the light, and which reflects scattered light on the subject surface. The light reflecting member includes a first reflecting surface and a second reflecting surface positioned closer to the transducer than the first reflecting surface, and a distance between the first reflecting surface and the second reflecting surface is an odd multiple of a half wavelength of a predetermined wavelength included in an acoustic wave generated from the light reflecting member by the scattered light.

Abstract: The present invention provides an acoustic waveguide for determining and continuously monitoring the degree, location and type of obstructions in liquid-filled tubes or catheters using acoustic waves. The tube's wall has an intermediate layer positioned between a tube outer wall and a tube inner wall of the tubea and the intermediate layer is made of a material having a difference in acoustic impedance of at least one order of magnitude with respect to that of the liquid present in or outside the waveguide reducing or eliminating the amount of acoustic energy that radiates through the tube.

Abstract: There are provided embodiments for providing a color Doppler image based on qualification curve information. In one embodiment, an ultrasound system comprises: an ultrasound data acquisition unit configured to acquire ultrasound data corresponding to a living body including a moving target object; a storage unit for storing qualification curve information for determining blood flow signals of the target object, clutter signals and noise based on velocity and power components of Doppler signals; and a processing unit configured to form first Doppler signals based on the ultrasound data, perform a clutter filtering process upon the first Doppler signals to form second Doppler signals, calculate velocity and power components of the second Doppler signals, form a color Doppler image based on the calculated velocity and power components, and perform a blending process upon the color Doppler image based on the calculated velocity and power components and the qualification curve information.

Abstract: The invention relates to a method and a device for detecting, measuring and evaluating defects in an object and/or specific material property of an object using a phased array wave technique. The device comprises of a phased array transceiver probe/source and control unit for use in a phased array wave technique for transmitting and receiving wave signals on and from the area to be inspected. The phased array source is divided into a plurality of virtual probes/sources and each virtual probe/source comprises of plurality of elements arranged sequentially but without phasing for excitation.

Abstract: A method and system are described for examining the interior material of an object from a surface of an object using ultrasound having a frequency of at least 100 kHz. The method comprises the step of transmitting at least a first ultrasound signal by a first ultrasound transmitter of a first number of ultrasound transmitters to the interior material of the object for forming a first image in order to determine, according for example to the principle of inverse wave field extrapolation, where in the interior material of the object reflections and/or diffractions occur. Reflections and/or diffractions of the first ultrasound signal from the interior material of the object are received using a second number of ultrasound receivers which are acoustically coupled to the surface of the object at positions which are distributed in at least one dimension of the surface of the object.

Abstract: An apparatus includes a cantilevered element including a coating material having an affinity for at least one compound. The apparatus further includes a first capacitive plate and a second capacitive plate that are each spaced from and capacitively coupled to the cantilevered element. The first capacitive plate is configured to induce a vibration in the cantilevered element at a frequency related to a mass of the cantilevered element. A frequency detector is coupled to the second capacitive plate to detect a change in vibrational frequency of the cantilevered element as a result of at least one particle of the at least one compound coupling to the coating material.

Abstract: A tool for manipulating a transducer assembly. The tool had a shaft to space the transducer assembly from a handle end. The tool rotatably mounts the transducer assembly so that the transducer assembly can transmissively coupled to and follow an arcuate scanning path. The tool includes a guide member for following an edge of a component to be tested.

Abstract: An ultrasonic transducer arrangement for inspecting a pipe to fitting weld with restricted scanning access. A TOFD ultrasonic send transducer is mounted adjacent one end of a frame. A TOFD ultrasonic receive transducer is mounted on the frame and spaced linearly apart from and aligned with the TOFD send transducer. The TOFD send and receive transducers are each positioned at an angle that matches the external radius of curvature of the pipe. A phased array curved, wedge, send/receive transducer is mounted on the frame and spaced radially apart from the TOFD transducers.

Abstract: A urea solution quality determining system may include a urea tank in which a urea solution is filled through a charging hole, a test chamber positioned below the charging hole for holding a portion of the urea solution, a main line connected to the urea tank at a lower part of the urea tank below the test chamber, a test line connected to the test chamber, a pumping line to which the main line and the test line are joined, a pump in the pumping line to pump the urea solution from the test chamber or from the urea tank, a control valve for selectively connecting the main line or the test line to the pumping line, and an injector at an end of the pumping line to inject the urea solution into an exhaust line through which an exhaust gas flows. A method is also described.

Abstract: Provided are a method of semi-quantitatively evaluating concrete carbonation including the steps of a specimen preparing step of preparing a concrete specimen for identifying a degree of carbonation, a carbonation depth measuring step of measuring a carbonation depth of the specimen by a method of promoting carbonation of the specimen using a carbonation promoting tester and applying an indicator, an X-ray diffraction (XRD) analyzing step of qualitatively analyzing components of the specimen by an XRD method after cutting the specimen from a top end to a predetermined depth and crushing the specimen. Thus, the method of the present invention may calculate the exposure time of concrete carbonation by converting the analysis result value of XRD to the result value of TG-DTA.

Abstract: This invention relates to a method of quantitative analysis of hexavalent chromium in a chromate coating on a substrate. In this method a substrate on which the chromate coating is formed is immersed into an aqueous solution containing lithium hydroxide to extract hexavalent chromium within an extraction solution. Quantitative analysis of extracted hexavalent chromium in the extraction solution is then performed.

Abstract: A biosensor cartridge includes a plasma separator, a plasma metering chamber, a mixer, and a biosensor.

Abstract: A hematology analyzer is provided. In certain embodiments, the hematology analyzer comprises: a) a flow cell; b) a light source for directing light to the flow cell; c) a plurality of detectors for detecting a plurality of optical characteristics of a blood cell passing through the flow cell; and d) a data analysis workstation programmed to: i. enumerate test blood cells passing through the flow cell; and ii. flag a blood sample as containing lysis-resistant red blood cells or fragile white blood cells.

Abstract: Provided herein are microfluidic devices that can be used as a 3D bioassay, e.g., for drug screening, personalized medicine, tissue engineering, wound healing, and other applications. The device has a series of channels {e.g., small fluid channels) in a small polymer block wherein one or more of the channels can be filled with a biologically relevant gel, such as collagen, which is held in place by posts. As shown herein, when the device is plated with cells such as endothelial cells, new blood vessels grow in the gel, which is thick enough for the cells to grow in three dimensions. Other channels, e.g., fluid channels, allow drugs or biological material to be exposed to the 3D cell growth. Cells, such as endothelial cells, can be cultured and observed as they grow on the surface of a 3D gel scaffold, where e.g., rates of angiogenesis can be measured, as well as intervascularization and extravascularization of cancerous cells.

Abstract: The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating cancer in a subject. Also disclosed are methods of inhibiting SCF-Skp2 activity and a method of identifying inhibitors of SCF-Skp2 activity.

Abstract: The invention disclosed herein provides methods for the examination and/or quantification of biochemical pathways that are disregukted in pathologies such as cancer and to reagents and kits adapted for performing such methods. For example a correlation between VHL loss and mTOR inhibitor sensitivity in human kidney cancer cells is disclosed, indicating that VHL loss confers autonomous and angiogenic competitive advantages to such cells.

Abstract: A biochemical detection unit for detecting a sample and a biochemical device having the biochemical detection unit and a releasing unit are provided. The biochemical detection unit includes a photoconductor plate, a receptor, and a resistance sensing component. The receptor specifically binds to the sample so that the illumination projected on the photoconductor plate will change to vary the resistance value of the photoconductor of the photoconductor plate.

Abstract: The present disclosure provides methods and/or kits for detecting an analyte in a sample. Some embodiments provide a method for detecting a non-nucleic acid analyte in a sample using a solid substrate comprising a bound immobilization agent and an antibody capture agent and a detectable agent, which can bind to the analyte. The antibody capture agent comprises, at a plurality of sites, a ligand for the immobilization agent. A complex between the analyte, the antibody capture agent and a detectable agent is formed and immobilized on the solid substrate by binding between the immobilization agent and the ligand. In some embodiments, the ligand and the immobilization agent are a binding pair comprising a peptide tag and an anti-peptide tag antibody.

Abstract: A biosensor system for the detection of particles includes a biosensor cartridge having a sensor surface. A biosensor magnet assembly is disposed on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface. The biosensor magnet assembly includes at least two magnetic sub-units separated by a gap. A first optical detection system detects the particles arranged at the same side of the cartridge as the magnet assembly. The magnet assembly and the first optical sensor are disposed such that the optical detection is accomplished through the gap of the magnet assembly.

Abstract: The present invention relates to a test system for visual analysis and to the use thereof in the point-of-care testing field.

Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.

Abstract: The invention provides a method and a kit for measuring the levels of serum fetuin-A in children to reflect the severity of invasive pneumococcal diseases caused by Streptococcus pneumoniae, including necrotizing pneumonia and hemolytic uremic syndrome. The mean fetuin-A levels in the HUS patients are significantly lower (207±80 mg/L, p<0.001) when compared to patients with lobar pneumonia (610±190 mg/L) and the healthy controls (630±250 mg/L). A serum fetuin-A level is a useful biomarker to classify the severity of pneumococcal infection in children. The level of biomarker fetuin-A can be monitored and evaluated by enzyme linked immunosorbent assay and Western blot hybridization.

Abstract: The invention provides compositions and methods useful for early detection of congenital CMV infection, predicting the likelihood and severity of congenital CMV disease, and monitoring the efficacy of therapeutic approaches. Compositions of the present invention include biomarkers that are differentially expressed in CMV-infected mothers and fetuses compared to uninfected individuals.

Abstract: The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the KRT5, KRT7, NapsinA, TTF1, TP63, and/or MUC1 proteins that are particularly advantageous for quantifying the KRT5, KRT7, NapsinA, TTF1, TP63, and/or MUC1 proteins directly in biological samples that have been fixed in formalin by the method of Selected Reaction Monitoring (SRM) mass spectrometry, or what can also be termed as Multiple Reaction Monitoring (MRM) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.

Abstract: A method for diagnosing a cancer characterized by over expression of CEACAM1 using an anti-CEACAM1 antibody or antibody fragment that recognizes CEACAM1 and comprises the same CDR sequences in the same orientation as the CDRs of the antibody produced from a hybridoma cell which has been deposited under ATCC Accession Number PTA-9974.