Abstract: There is disclosed an apparatus for treating a sexual dysfunctional female patient, comprising an implanted stimulation device adapted to stimulate at least a part of the sexually responsive tissue of the vulva or the wall of the vagina of the patient by movement of said stimulation device and contact between said stimulation device and the sexually responsive tissue or the wall of the vagina. A system and an operation method for the treatment of female sexual dysfunction are also disclosed.

Abstract: Disclosed is a stimulation device comprising a first arm (2) having a proximal end portion (2a) and a distal end portion (2b) and a second arm (4) having a proximal end portion (4a) and a distal end portion (4b), wherein the first arm (2) and the second arm (4) are connected with each other at their respective proximal end portion (2a, 4a) so as to form an essentially U- or V-shaped arrangement with the distal end portions (2a, 4a) of the first and second arms (2, 4) being spaced from each other so that the first arm (2) is adapted to be inserted into a vagina and the second arm (4) is adapted to get, essentially at the same time, into contact with a body portion outside the vagina.

Abstract: An eye mask containing a loose filling of beads and an electro-massaging unit positioned in the mask to provide vibratory massage to a user's eye, nose and to the loose filling of beads.

Abstract: In one embodiment, the present invention includes an infrared apparatus to heat a body. The infrared apparatus includes layers. The first layer has a first conductive path coupled to pass a first current. The second layer has a second conductive path running coincident to the first conductive path. The second layer terminates an electric field produced within said first layer. The first conductive path includes a resistive element that produces heat from the current.

Abstract: While such systems and methods can include any suitable component, in some cases, they include a first and a second piece of sauna housing and a sauna heater. In some such cases, the second piece of sauna housing slidingly couples with the first piece to define an interior sauna chamber. Additionally, in some cases, a first portion of the second piece of sauna housing is configured to slidably fit within the first piece such that a volume of the sauna chamber is configured to increase and decrease, respectively, when the second piece is moved into an extended position or when the second piece is moved from the extended position into a collapsed position in which the second piece nests within the first piece. In some cases, the first and second pieces include a ceiling that is configured to extend over a user within the sauna chamber. Other implementations are described.

Abstract: A method of treating a mental disorder of a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at or near an acupoint corresponding to at least one of a trigeminal nerve and an occipital nerve of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device, the stimulation sessions to at least one of the trigeminal nerve and the occipital nerve by way a central electrode and an annular electrode located on the electroacupuncture device in accordance with the duty cycle.

Abstract: A transparent blister pack for pharmaceuticals includes a blister made from an aluminium based laminate and a lidding foil made from a transparent barrier film. The transparent blister has superior barrier properties. The transparent blister may be completely halogen free.

Abstract: The invention relates to an installation and a method for manufacturing infusion bags with an access and an injection stopper. In addition, the invention relates to such a bag and to various injection stoppers. In the system according to the prior art, a tube piece, onto which the port is fitted, is welded into a bag. The port is not additionally fixed but is merely held by the tension in the tube. This can theoretically lead to impermeability problems. In contrast, in the new system proposed herein, the port is directly welded into the bag, so that the tube serving as an intermediate piece is dispensed with. The resulting advantage is more specifically that more than 30 mm of tubing can be saved in each bag, which not only makes the construction of the installation less expensive, but also eliminates the relatively expensive tubes. In addition, the tube and the port can be optionally welded with the same welding tool.

Abstract: Devices and systems for isolating gastrointestinal microflora from stool collected from a donor are provided. Stool is collected from a donor in a container as the donor is defecating. A solvent is introduced into the container and the container sealed to place its contents in a sealed environment. Various agents can be added to achieve dissolving, colorizing, deodorizing, or for further therapies. The solvent and collected stool is homogenized into a mixture which is then filtered by a multi-stage filter system to create a solution containing microflora in the desired consistency. This solution can be dispensed via an enema tube or other delivery apparatus for infusion into a patient's gastrointestinal tract.

Abstract: A drug container closure for mounting on an open-topped drug container to form a ready-to-use drug reconstitution assemblage for use with a needleless syringe. The drug container closure includes a drug container stopper for sealing the drug container and a fluid transfer member with an integral needleless syringe connector and a puncturing cannula. The fluid transfer member is manually disposed along a diametric inverted L-shaped track pair from an initial non-puncturing position to a puncturing position. The inverted L-shaped track pair includes one-way snap members to prevent a user returning the fluid transfer member to an earlier position and indicating progress of the user activation.

Abstract: An apparatus for removal of premixed drugs or reconstitution of lyophilized drugs and for the injection of the reconstituted drug into the patient. The apparatus includes a syringe assembly and an adapter assembly that can be removably connected to a medicament container containing a premixed drug or lyophilized medicament. The syringe assembly of the apparatus includes a liquid chamber between the forward end of the body portion and the piston and a syringe cannula assembly. The syringe cannula assembly, which can be removably interconnected with the body portion, comprises a cannula support and a hypodermic needle sealably connected to the cannula support. The adapter assembly comprises an adapter preferably molded from a moldable plastic that includes a top wall, an adapter cannula connected to and extending from the top wall and a variety of connectors connected to the top wall for removably interconnecting the adapter with the medicament container.

Abstract: A pill cutting device for use in dividing a pill into a plurality of pieces. The pill cutting device includes a lower housing pivotally secured to an upper housing. The lower housing includes a pill holder having a recessed area in which a pill can be positioned. The pill holder further includes a pair of movable support arms, wherein the support arms can be used to hold pills of different shapes and sizes in a desired position for cutting. The upper housing includes a cutting blade for use in cutting the pill into several pieces, wherein the cutting blade is aligned with the recessed area of the pill holder. Preferably, the cutting blade comprises an X-shape so as to divide the pill into four pieces. The lower housing further includes a chamber in which the cut pill can be stored after being split into multiple pieces.

Abstract: A support system for a baby bottle has a support body having a generally cylindrical portion. A channel is defined within the support body. A slot is defined between slot edges of the support body extending between a first end portion and a second end portion. First and second handle portions are coupled to the support body. The first and second handle portions are coupled to the support body at an angle less than about 120 degrees apart from each other about a surface of the support body. The support body is sized and configured to support a baby bottle positioned within the channel defined within the support body. In some embodiments, the first and second handle portions have handle grip portions that are coupled to the support body at an angle between about 5 degrees and about 30 degrees relative to a surface of the support body.

Abstract: The present invention provides a novel curable composition in which a reaction is caused to occur between a hydroperoxide and a thiourea compound to initiate polymerization of a radical polymerizable monomer and which has excellent adhesive properties, moderate curability, and excellent long-term storage stability. The present invention relates to a curable composition (A) containing: a radical polymerizable monomer (a1) having no acidic group; a hydroperoxide compound (a2); and at least one cyclic thiourea compound (a3) selected from the group consisting of a substituted ethylenethiourea compound (a3-1), a substituted propylenethiourea compound (a3-2), and a substituted butylenethiourea compound (a3-3) each having a specific structure with a cyclic structure moiety into which a substituent is introduced.

Abstract: The invention relates to the use of glass ceramics based on a high quartz mixed crystal system for dental purposes, which can be easily mechanically processed in an intermediate stage of crystallization and present high-strength, highly translucent and chemically stable glass ceramics following complete crystallization, wherein said glass or ceramics still have phosphorus and a transition metal compound, selected from titanium and zirconium or a mixture thereof.

Abstract: A sheet-like hair care product including (A) a substrate sheet containing cellulosic fibers and having a bending resistance of 10 to 70 mm measured by the 45° cantilever method in accordance with JIS L1096:2010 and (B) a liquid cosmetic composition. The substrate sheet (A) is impregnated with 1 to 50 g of the liquid cosmetic composition (B). The substrate sheet impregnated with the liquid cosmetic composition is preferably packaged in a packaging container having an access opening with an area of 25 to 4000 mm2 and an openable and closable lid sealing the contents.

Abstract: The object is the invention is to provide hollow, and preferably porous, spherical CaP particles preferably without the use of strontium ions. This is achieved by a method comprising the steps: a) Providing an aqueous buffer solution of purified water having a pH of 6-10 comprising 20-200 mM sodium ions, 0.1-10 mM potassium ions and 1-10 mM phosphate ions, and wherein the buffer solution is essentially free from strontium; b) adding calcium ions in the range of from 0.1 to less than 2 mM, and magnesium ions in the range of 0.01-5 mM to the buffer solution and forming a mixture; c) heating the mixture of step b) at 60-200° C. for at least 5 minutes d) isolating the formed particles; and e) optionally washing the isolated particles using a suitable solvent. The particles comprise 40-70 weight % of calcium, 20-40 weight % of phosphate and 1-25 weight % magnesium. The Ca/P weight ratio is in the range of 1.10 to 1.90 and more than 80 % of the particles have a particle size between 200 to 1500 nm.

Abstract: This invention relates to a cosmetic composition comprising a physiologically acceptable medium containing aqueous phase, an oily phase and nacre particles, constituted of a substrate partially or totally coated with one or more layers.

Abstract: Gel-based lipstick compositions are disclosed comprising an ester terminated poly(ester-amide) (ETPEA) polymeric gellant, a first wax component having a melting point above the sol-gel transition temperature of the ETPEA gellant, a second wax compositions having a melting point equal to of below the sol-gel transition temperature of the ETPEA gellant, optionally a silicone T-resin co-gellent, and one or more oils capable of forming a gel with the ETPEA gellant. The gel compositions are solid or semi-solid at room temperature and are capable of being molded into self-supporting sticks. The disclosed gels provide high gloss films when applied to the lips and/or provide a rheology characterized by a high viscosity over repeated shear cycles.

Abstract: A moisturizing liquid liner composition comprising a hydrophobic moiety and an emulsifier is described. Further, a substrate comprising a barrier layer and a moisturizing liquid liner composition comprising a hydrophobic moiety and an emulsifier is described. The substrate may be incorporated into an article.

Abstract: A chlorine-containing silicate glass comprising SiO2, at least 0.5 mole percent metal chloride and at least 10 mole percent of MgO, SrO, BaO, and CaO combined.

Abstract: The present invention relates to a cosmetic process for treating keratin materials, which can give them, especially in a long-lasting and reversible manner, interesting cosmetic properties; this process comprising the application to said materials: in a first stage, of a cosmetic composition comprising at least one graftable species, comprising at least one unit of formula (Ia): and in a second stage, of a cosmetic composition comprising at least one cosmetic active agent bearing at least one unit of formula (Ia): The invention also relates to a kit comprising said compositions.

Abstract: The present invention relates to cosmetic compositions comprising cyclodextrin as UV-and IR-radiation screen agent, and skin treatments wherein such compositions are spread upon the skin or hair of the subject to be treated.

Abstract: The present provides cosmetic compositions such as mascara. More specifically, the invention relates to cosmetic compositions comprising low opacity waxes.

Abstract: The invention provides antibacterial combinations of essential oils comprising bisabolol and one or more essential oils selected from citral, carvacrol, oregano extract, and rosemary, or comprising carvacrol and one or more essential oils selected from bisabolol, thymol, and rosemary, together with compositions, e.g., oral care compositions, comprising these combinations, and uses therefore.

Abstract: The present invention relates to the topical cosmetic use of a Polygonum bistorta extract for stimulating the expression of perlecan and/or dystroglycan, in particular in the extracellular matrix and/or in the epithelial basement membrane, especially the dermoepidermal junction. It also relates to a cosmetic care method comprising the application, to at least one concerned area of healthy skin and/or healthy mucous membrane and/or healthy scalp, of a Polygonum bistorta extract or of a cosmetic composition comprising such an extract for stimulating the expression of perlecan and of dystroglycan, in particular in the extracellular matrix and/or in the epithelial basement membrane, especially the dermoepidermal junction.

Abstract: Described herein is a method of treating aging skin in a subject, the method comprising applying a topical skin care composition to a surface of the skin of the subject in need thereof, the composition containing a whole plant extract solution of Dendrobium Huoshanense

Abstract: A novel herbal vaporization device (HVD) and method is disclosed. The HVD includes a recharging unit for storing therein of a vaporization unit having a heating chamber disposed at a first end thereof for receiving of loose leaf herbal material and for providing of heat thereto, the vaporization unit comprising a second end disposed opposite the first end with a fluid pathway between the two ends. In a first mode of operation the vaporization unit is for being recharged from the recharging unit and in a second mode of operation the vaporization unit is for use in vaporizing of loose leaf herbal material inserted into the heating chamber for having at least partially vaporized loose leaf herbal material and ambient air to flow through the fluid pathway.

Abstract: According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

Abstract: Systems and methods are described for treating un-met medical needs in migraine and related conditions such as cluster headache. Included are treatments that are both rapid onset and long acting, which include sustained release formulations, and combination products. Also included are treatments for multiple symptoms of migraine, especially headache and nausea and vomiting. Systems that are self contained, portable, prefilled, and simple to self administer at the onset of a migraine attack are disclosed, and preferably include a needle-free injector and a high viscosity formulation, to eliminate such issues as fear of self administration with needles, and needle stick and cross contamination.

Abstract: There is provided glucagon formulations suitable for preparing coatings on microneedle patches for the transdermal delivery of glucagon. The coated patches may be used for the treatment of low blood sugar in diabetic patients. Also provided are glucagon loaded patches, methods for their preparation, and methods of their use.

Abstract: Compositions comprising a combination of epigallocatechin gallate (EGCG) and non-digestible oligosaccharides are described to prevent and/or treat one or more gastrointestinal (GI) imbalances associated with digestive disorders.

Abstract: Therapeutic agent delivery systems, which include a thermally-sensitive copolymer and optionally a therapeutic agent, are disclosed. The copolymer is water soluble and biodegradable and, in accordance with exemplary embodiments, includes hydrophobic and hydrophilic portions. The systems may include supplemental compounds, such as polymeric nanoparticles, micelle compounds, or a combination thereof, to further provide sustained release of the therapeutic agent.

Abstract: The present invention provides pharmaceutical compositions comprising a chylomicron and a carotenoid. The present invention also provides pharmaceutical compositions comprising a micelle and a carotenoid, suspended in an aqueous solution and suitable for intravenous administration. The bioavailability of the carotenoid of the pharmaceutical composition is higher relative to the bioavailability of free carotenoid.

Abstract: The present invention relates to mesoporous silica coated nanoparticles comprising a metal oxide nanoparticle core; and a mesoporous silica shell encapsulating metal oxide core; wherein said mesoporous silica shell and the metal oxide core are not in full contact. The nanoparticles of the invention are useful as diagnostic and therapeutic agents.

Abstract: Compositions of the present invention, comprising the combination of enterically coated and uncoated pancreatic enzyme-containing beads are useful for treating or preventing pancreatitis pain, and optionally disorders associated with digestive enzyme deficiencies.

Abstract: The invention discloses spray-dried compositions for inhalation and methods for preparing such powder compositions. The compositions of the invention are produced by spray-drying taurine under conditions that (i) retain the physical and chemical stability of the composition during spray drying and upon storage, (ii) protect the powder composition from aggregation and (iii) provide particles suitable for aerosolisation.

Abstract: Methods and compositions are provided which comprise effective amounts of analgesic to treat a subject, including reducing or eliminating an adverse effect associated with the analgesic.

Abstract: The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an amine-containing compound (e.g., an opioid) (including salts thereof) and a pharmaceutically acceptable salt of a non-NSAID cyclic organic acid compound.

Abstract: Disclosed herein is a dispersible tablet composition including a pharmacologically active ingredient and at least one excipient that reduces the sedimentation rate of the active ingredient and a process for preparing the same.

Abstract: A device and method for administering a consistent and steady dosage of Metformin to patients which includes an implantation component with a composition of Metformin adapted to be inserted either subdermally or subcutaneously to administer a steady incremental dosage of Metformin to the patient throughout a predetermined period of time. A Metformin drug suspension is dispersed in a plurality of microreservoirs and the mixture of microreservoirs and placed in a silicone polymer tube for in situ polymerization and molding, which would allow Metformin molecules to initially diffuse through the microreservoir membrane and then through the silicone polymer containing membrane. In a further embodiment, Metformin implants may be formed by dispersing the drug in a copolymer matrix, which is then coated with a copolymer that serves as a rate-controlling membrane. The drug permeation through the polymer membrane occurs at a rate that is slower than that through the polymer matrix.

Abstract: A film-forming composition including a fluidized hydroxypropyl starch and sorbitol, a film-coating method using the composition, and film-coated solid forms including a fluidized hydroxypropyl starch and sorbitol in the coating are described.

Abstract: The present invention relates to an improved gelatinous coated dosage form having two end regions coated with gelatinous materials and an exposed circumferential band. Openings are provided in at least the exposed band to reveal the core material. The invention also relates to methods for manufacturing such gelatinous coated dosage forms.

Abstract: The present invention relates to coatings and methods for the administration of cannabinoids to a patient, and in a specific embodiment, the coatings and methods may utilize or include cannabinoids, and one or more active pharmaceutical ingredients, wherein said coating is configured for oral delivery through a capsule or tablet.

Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.

Abstract: The present invention relates to a process for preparing erythrocytes loaded with one or more substance of pharmaceutical interest. The present invention is also directed to loaded erythrocytes thus obtained and pharmaceutical compositions comprising said population of loaded erythrocytes as well as therapeutic application thereof, in particular in the treatment of Ataxia telangiectasia.

Abstract: The present invention relates to a molecule delivery technology and a carrier technology, which may selectively deliver a material to a desired specific cell and living tissue. The present invention may be utilized in the field of a drug carrier which effectively delivers an imaging probe and a therapeutic agent to an affected part.

Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.

Abstract: The invention relates to biodegradable PLGA bionanoparticles encapsulating the GSE24-2 peptide with telomerase activity and to pharmaceutical, cosmetic and biotechnological compositions comprising same. The pharmaceutical compositions are useful for treating diseases presenting a telomerase deficiency, such as dyskeratosis congenita, and diseases presenting ageing characteristics, such as Werner syndrome, Rothmund Thompson syndrome, and other diseases where there is DNA damage such as ataxia telangiectasia. The invention likewise relates to the method for producing said bionanoparticles by means of a w/o/w double emulsion technique.

Abstract: Provided is a transdermal delivery system consisting of a backing layer, a drug-containing matrix layer, and a release layer, wherein the drug-containing matrix layer includes (a) donepezil or a pharmaceutically acceptable salt thereof as an active ingredient, (b) a mixture of high molecular weight polyisobutylene having a weight-average molecular weight ranging from 400,000 to 3,000,000 and low molecular weight polyisobutylene having a weight-average molecular weight ranging from 25,000 to 300,000 as an adhesive, and (c) a permeation enhancer in not more than 3% by weight based on the total weight of the drug-containing matrix layer.