Patents Issued in March 10, 2016
  • Publication number: 20160067145
    Abstract: A medicine cup, preferably stackable, disposable, of frustoconical configuration and optionally biodegradable. The medicine cup includes a cup member for the medicine and an infection control tab coupled to the cup member. The tab is preferably coplanar with and integrally mounted to the sidewall of the cup member and has a textured frictional surface. The infection control tab is for holding the cup by the health care provider, the tab minimizing the possibility of contamination of the cup and patient through the health care provider's hands.
    Type: Application
    Filed: November 5, 2015
    Publication date: March 10, 2016
    Inventor: Dennis Christopher Riordan
  • Publication number: 20160067146
    Abstract: The present patent application discloses a multifunctional feeding-bottle, including an outer cup, a liner, a nipple assembly connected to an opening of the outer cup, and a bottom cover connected to the bottom of the outer cup. The feeding-bottle further includes a valve piece disposed between the bottom of the outer cup and the bottom cover. An air inlet is disposed in a central part of a body of the valve piece. A stiffener is disposed at a part other than the air inlet. A cavity is formed between one side of the valve piece provided with the stiffener and the bottom cover. A sealing protrusion capable of sealing the air inlet is disposed at a central part of the bottom cover. An air vent is disposed at a part different from the sealing protrusion. The liner is disposed in the outer cup, and is configured to be removed from the outer cup.
    Type: Application
    Filed: June 22, 2015
    Publication date: March 10, 2016
    Inventor: Qian ZHOU
  • Publication number: 20160067147
    Abstract: A transfer lid for a fluid container, having an attachment collar for removably attaching the transfer lid to the fluid container, and an inner collar arranged generally concentrically with and spaced inwardly from the attachment collar, the inner collar having a vent opening such as a vent slot extending therethrough.
    Type: Application
    Filed: September 3, 2015
    Publication date: March 10, 2016
    Applicant: NEOMIED, INC.
    Inventors: Benjamin Martin DAVIS, Aaron N. INGRAM, Mark M. COSTELLO, Tony DOHERTY, John BURKE
  • Publication number: 20160067148
    Abstract: Systems, methods, and apparatus for gastric pressure relief, flow regulation, location, gastric residual volume, a placement reminder, bidirectional fluid flow markings, reintroducing gastric material, collection reservoir raising, collection reservoir hanging, a drain port, setting tube length, and vent membranes. A gastric pressure relief system is used in connection with an enteral feeding system, which includes a feeding container, administration tubing and a delivery tube, where the gastric pressure relief system is interposed between the administration tubing and the delivery tube. The gastric pressure relief system includes a collection reservoir with a gas vent to ambient atmosphere, relief tubing secured to both the collection reservoir and a multi-way connector. The multi-way connector joins the administration tubing to the relief tubing and a delivery tube at a point below a patient's stomach, which is designated on a placement reminder apparatus.
    Type: Application
    Filed: September 4, 2015
    Publication date: March 10, 2016
    Inventors: Jeffrey S. Nordquist, Robert D. McVey, Elizabeth J. Klodd, Jon W. Newland, Crystal E. Koelper, Jill F. Lazar, Renee M. Seeler, Karin A. Rogers, Steven M. Maraone
  • Publication number: 20160067149
    Abstract: A photo-chemically activated micro-bubble based root canal disinfection method for disinfecting a shaped root canal comprises (a) introducing a photoactive solution into the root canal, the photoactive solution containing a photoactive compound (such as methylene blue) dissolved in an alcohol carrier solution (such as polyethylene glycol and/or ethanol); (b) removing excess photoactive solution from the root canal; (c) introducing a micro-bubble solution comprised of an oxygen carrier (such as perfluorocarbon), an oxidizing agent (such as hydrogen peroxide) and a surfactant (such as a nonionic polyoxyethylene surfactant); (d) sonically or ultrasonically activating the micro-bubble solution in the canal; and (e) introducing light into the canal.
    Type: Application
    Filed: September 4, 2014
    Publication date: March 10, 2016
    Inventor: Anil Kishen
  • Publication number: 20160067150
    Abstract: The present disclosure relates to a cosmetic or dermatological sheet impregnated with a sunscreen fluid cosmetic composition. Specifically, the present disclosure relates to a cosmetic or dermatological sheet impregnated with a sunscreen fluid cosmetic composition and method to apply sunscreen to the human user's back or entire body. The sheet may have stitching and other composition or structural aspects to increase the structural integrity, hand slits, mitts or finger holes in the fabric, and/or areas that are not impregnated with a sunscreen composition to enable the user to more easily or tightly grasp the sheet during application of the sunscreen composition. Additionally, the sheet may be used to apply sunscreen to the user's back or entire body more than once before discarding the sheet and may include or consist of dyes, paints, tints or emboss to change the color or design of the sheet.
    Type: Application
    Filed: November 13, 2015
    Publication date: March 10, 2016
    Inventors: Terry Zickerman, Stephen Liaci
  • Publication number: 20160067151
    Abstract: The present disclosure relates to a cosmetic or dermatological sheet impregnated with a sunscreen fluid cosmetic composition. Specifically, the present disclosure relates to a cosmetic or dermatological sheet impregnated with a sunscreen fluid cosmetic composition and method to apply sunscreen to the human user's back or entire body. The sheet may have stitching and other composition or structural aspects to increase the structural integrity, hand slits, mitts or finger holes in the fabric, and/or areas that are not impregnated with a sunscreen composition to enable the user to more easily or tightly grasp the sheet during application of the sunscreen composition. Additionally, the sheet may be used to apply sunscreen to the user's back or entire body more than once before discarding the sheet and may include or consist of dyes, paints, tints or emboss to change the color or design of the sheet.
    Type: Application
    Filed: November 13, 2015
    Publication date: March 10, 2016
    Inventors: Terry Zickerman, Stephen Liaci
  • Publication number: 20160067152
    Abstract: The invention relates to cosmetic cleaning agents, which contain a) polylactic acid particles and b) at least one additional organic or inorganic, water-insoluble abrasive component that is different from a) and has absolute particle sizes in the range of 40 to 500 ?m. Regular use of the cleaning agent leads to improvement of the complexion, in particular to pore refinement in the face, back, and cleavage region, and/or to matting the skin.
    Type: Application
    Filed: November 18, 2015
    Publication date: March 10, 2016
    Inventors: Jutta Franklin, Barbara Heide, Thomas Foerster
  • Publication number: 20160067153
    Abstract: The present invention concerns a translucent gel system, notably a hair conditioner gel, comprising at least a carboxylic acid, an alkoxylated alkyl or alkenyl amine and a cationic surfactant. Such a translucent gel system provides an excellent conditioning effect for washing skin and/or hair and a high transmittance.
    Type: Application
    Filed: April 23, 2014
    Publication date: March 10, 2016
    Applicant: RHODIA OPERATIONS
    Inventors: Xi CHEN, Hai Zhou ZHANG
  • Publication number: 20160067154
    Abstract: A stable, multiphase liquid isotropic cleansing composition is described that contains high levels of Petrolatum and shows a substantial decrease in reflectance compared with isotropic cleansing compositions containing other oils and liquid crystalline compositions with similar levels of oils. The inventive composition has a total of less than 2% by wt. of other oils such as glyceride, mineral and silicone oils, or blends thereof.
    Type: Application
    Filed: November 13, 2015
    Publication date: March 10, 2016
    Applicant: Conopco, Inc., d/b/a UNILEVER
    Inventors: Nicolas E. Restrepo, Alexander Kingston Shutak, Liang Sheng Tsaur, Vivek Subramanian
  • Publication number: 20160067155
    Abstract: Provided is a cosmetic product which can generate a carbon dioxide gas to cause foaming by a simple method and having excellent usability. Provided is a cosmetic product comprising a first composition and a second composition different from the first composition as constituent elements of the cosmetic product and which foams by mixing the first composition and the second composition, wherein the first composition is a liquid or creamy composition containing a bicarbonate and/or a carbonate, and the second composition is a liquid or creamy composition containing an ?-hydroxy acid and/or a saturated dibasic acid in which the content of water is 1.0-fold or less in terms of weight ratio with respect to the ?-hydroxy acid and/or the saturated dibasic acid.
    Type: Application
    Filed: September 10, 2015
    Publication date: March 10, 2016
    Inventors: Tadahiro Shimada, Hiroko Shimada, Hanae Shimada, Yo Nakajima
  • Publication number: 20160067156
    Abstract: A droplet for delivering toothpaste to a user can be provided. The droplet can include a dissolvable outer membrane defining a volume with toothpaste inside the volume. The outer membrane can be formed from dissolvable film strip technology and include a tail or corner portion, which is configured to be embedded into the bristles of a toothbrush. In one aspect of this embodiment, the outer membrane of the droplet can form a pillow-like shape. The droplet further can include one or more extensions coupled to the outer surface of the outer membrane, where the one or more extensions can have a triangular shape, a barb shape or the like. In one aspect of this embodiment, the droplet further can include a logo, a cartoon character, a word or the like printed on the outer membrane. The plurality of extensions can form irregularities on the outer surface of the body section of the outer membrane.
    Type: Application
    Filed: September 8, 2014
    Publication date: March 10, 2016
    Inventor: Wayne R. Solan
  • Publication number: 20160067157
    Abstract: A method of instantly reducing the appearance of wrinkles and skin imperfections while smoothing the skin, which comprises applying a cosmetic composition comprising a fractal particle based gel.
    Type: Application
    Filed: November 5, 2015
    Publication date: March 10, 2016
    Inventors: Steven E. Brown, Ernest S. Curtis
  • Publication number: 20160067158
    Abstract: The invention relates to highly concentrated agents for the preparation of sunscreen final formulations, comprising (a) 15 to 50 wt. % of oily substance, (b) 4 to 30 wt. % of anionic surfactant, (c) 0.5 to 25 wt. % of further co-surfactant which differs from (b), (d) 25 to 75 wt. % of UV filter, and (e) optionally water and/or auxiliary substances to 100 wt. %. and its use for the preparation of sunscreen final formulations and the preparation thereof.
    Type: Application
    Filed: May 6, 2014
    Publication date: March 10, 2016
    Applicant: BASF SE
    Inventors: Matthias HLOUCHA, Esther KUESTERS, Stephanie ACKER, Heike FLOESSER-MUELLER, Jasmin SCHORB
  • Publication number: 20160067159
    Abstract: The present invention relates to antimicrobial formulations containing carvacrol and at least one of the following 2-phenoxyethanol, caprylyl glycol and hexylene glycol.
    Type: Application
    Filed: September 9, 2015
    Publication date: March 10, 2016
    Inventors: Manfred F. Dyck, Silke von Dyck, Eric Becktel, Irina Grigorian
  • Publication number: 20160067160
    Abstract: The present invention relates to the use of at least one 2-methylsuccinic acid diester derivative of formula (I) below: in a composition comprising, in a cosmetically acceptable medium, at least one liquid fatty phase and at least one lipophilic active agent, for dissolving the said active agent in the said liquid fatty phase and/or for improving the solubility of the said active agent in the said solid fatty phase. The present invention relates especially to a composition comprising, in a cosmetically acceptable medium, at least one liquid fatty phase, characterized in that it contains at least one 2-methylsuccinic acid ester derivative of formula (I) and at least one lipophilic active agent.
    Type: Application
    Filed: September 11, 2015
    Publication date: March 10, 2016
    Inventors: Herve Richard, Benoit Muller
  • Publication number: 20160067161
    Abstract: The invention relates to the use of compounds of formula (I) R—N1-spermidine, i.e. 1.4-butanediamine,N-(3-aminopropyl)-N1—R, (I) H2N —(CH2)3—N1(R)—(CH2)4—NH2, as such or in the form of pharmaceutically acceptable derivatives, as active principle in a cosmetic or pharmaceutical composition for resisting the effects of skin ageing through an anti-inflammatory action, by topical administration. Such compounds also have an antioxidant activity against oxygen free radicals (ROS) comparable with that of ?-tocopherol.
    Type: Application
    Filed: April 9, 2014
    Publication date: March 10, 2016
    Inventors: Giammaria GIULIANI, Anna BENEDUSI, Barbara MARZANI, Sergio BARONI, Ralf PAUS
  • Publication number: 20160067162
    Abstract: A compound of formula (I): wherein: R1 is H, benzyl, —CH2—O-benzyl, a straight or branched C1-C12 alkyl radical, a hydroxyalkyl radical or a polyhydroxyalkyl radical, R2 is H; a straight or branched C1-C12 alkyl radical; a —(CH2)3—CH?CH2 radical; a phenyl, naphthyl, furan, thiophene or pyrazole radical, optionally substituted by at least one group selected among methoxy, phenoxy, halogen, dimethylamine, trifluoromethyl and alkynyl, R3 is H; a vinyl radical optionally substituted by a carboxyalkyl; a nitrile; a carboxamide; a phenyl, naphthyl, furan, thiophene or pyrazole radical, optionally substituted by at least one group selected among methoxy, phenoxy, halogen, dimethylamine, trifluoromethyl and alkynyl; an aminoalkyl or aminocarboxyl radical; or an alkoxy radical, R4 is H, a protective grouping, a straight or branched C1-C12 alkyl radical, a hydroxyalkyl radical or a polyhydroxyalkyl radical, and when: R2 is H, R3 is —NHCOOC(CH3)3, R2 is a propyl, R3 is —CH?CH—COO—C2H5 or R1=R3=R4=H, R2 is a non-s
    Type: Application
    Filed: April 4, 2014
    Publication date: March 10, 2016
    Inventors: Nicolas GOUAULT, Khanh Hung NGUYEN, Sophie TOMASI, Karine COSTUAS
  • Publication number: 20160067163
    Abstract: Suggested is a composition comprising (a) sclareolide and (b1) at least one tyrosinase inhibitor; and/or (b2) at least one sun protection factor; and/or (b3) at least one anti-oxidants; and/or (b4) at least one anti-inflammatory agent; and/or (b5) at least one desquamating agent, on condition that compound a is present in an amount of from 0.00001 to 0.001% b.w.—calculated on the total composition.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 10, 2016
    Inventors: Imke MEYER, Mirjam KNUPFER
  • Publication number: 20160067164
    Abstract: Adhesion of a composition for nail coatings be improved by addition of a polyhedral oligomeric silsesquioxane (POSS). Nail coating compositions that benefit from the addition of a POSS include enamels, reactive composition such as those containing acrylates, solventless compositions and water-based compositions.
    Type: Application
    Filed: April 22, 2014
    Publication date: March 10, 2016
    Inventors: David Valia, Jamie Ellis
  • Publication number: 20160067165
    Abstract: Arbutin-containing compositions are useful for topical application to provide enhanced luminosity, brightening or lightening to the skin of a user and are at least 85% as efficacious (with regard to skin lightening, when used alone or in a system as measured by Chromameter® b* parameter values) as substantially corresponding compositions containing hydroquinone in an mount from about the same molar amount to about 1.5 times the molar amount of arbutin.
    Type: Application
    Filed: September 9, 2015
    Publication date: March 10, 2016
    Inventors: Judy Hattendorf, Steve Carlson
  • Publication number: 20160067166
    Abstract: The present invention relates to a topical composition comprising a natural organic oil and a porous cross-linked polymethylmethacrylate bead having a particle size Dv0 of greater 0.3 ?m, a Dv100 of less than 35 ?m and a Dv50 selected in the range of 6 to 15 ?m and an oil absorption capacity selected in the range of 1.2-2.5 cc/g. Furthermore the invention relates to the use of such polymethylmethacrylate beads to ameliorate the short and long-term sensory properties of a topical composition comprising a natural organic oil.
    Type: Application
    Filed: May 14, 2014
    Publication date: March 10, 2016
    Inventors: Achim BROCK, Christian GSTOETTMAYR, Aline HUEBER, Szilvia MESAROS, Juergen H. VOLLHARDT
  • Publication number: 20160067167
    Abstract: The present invention provides oral care compositions for treating tooth sensitivity. The composition comprises a synergistic mixture containing a copolymer having at least one repeating unit of alkyl vinyl ether functionality and a monomer having at least one repeating unit of ethylenically unsaturated dicarboxylic acid or anhydride functionality present in an amount of about 0.1 to about 50% (w/w) of the total mixture; and a homo polymer having repeating unit of alkyl vinyl ether functionality present in an amount of about 0.1 to about 50% (w/w) of the total mixture. These synergistic mixtures of polymers act as barriers for dentin flow and reduce pain and discomfort caused by tooth sensitivity and exhibits at least 60% average reduction in dentin flow.
    Type: Application
    Filed: November 15, 2013
    Publication date: March 10, 2016
    Applicant: ISP INVESTMENTS INC.
    Inventors: William E. Prosise, Gillian Giannone, Jeffrey Lynn, Cristian Grigoras, Jenn Shih
  • Publication number: 20160067168
    Abstract: The invention relates to oral and dental hygiene and cleaning agents which contain, in relation to their weight, between 0.001 and 25% by weight polylactic acid particles and between 1 and 30% by weight precipitated silicic acid(s) with a specific surface area according to ISO 5794-1, Appendix D, of ?60 m2/g. said agents exhibit a reduced damaging action in comparison to pure silicate-based compositions. In particular, the sensitivity of the teeth during and after the cleaning process is reduced.
    Type: Application
    Filed: November 18, 2015
    Publication date: March 10, 2016
    Inventors: Thomas Welss, Thomas Foerster, Markus Semrau, Kristin Miehlich, Claudia Hundeiker
  • Publication number: 20160067169
    Abstract: Oral and dental hygiene and cleaning agents, which contain, relative to the weight thereof, 0.001 to 25 wt % polylactic acid particles and 1200 to 1600 ppm fluoride have a substantially improved degree of fluoride deposition and offer an optimum compromise between applicability and plaque reduction.
    Type: Application
    Filed: November 18, 2015
    Publication date: March 10, 2016
    Inventors: Thomas Welss, Thomas Foerster, Markus Semrau, Kristin Miehlich, Claudia Hundeiker
  • Publication number: 20160067170
    Abstract: The anti-inflammatory and preventive action of antimicrobial substances can surprisingly be enhanced by the use of polylactic acid particles. Corresponding advantageous products are in particular oral and dental care and cleaning products that—based on the weight thereof—comprise 0.001 to 25 wt. % polylactic acid particles and 0.00001 to 5 wt. % of at least one antibacterial compound from the groups consisting of the benzoates and/or the parabens and/or the Cu salts and/or the Ag salts and/or triclosan and/or hexetidine.
    Type: Application
    Filed: November 18, 2015
    Publication date: March 10, 2016
    Inventors: Thomas Welss, Thomas Foerster, Markus Semrau, Kristin Miehlich, Claudia Hundeiker
  • Publication number: 20160067171
    Abstract: The invention relates to oral and dental hygiene- and cleaning agents having an improved taste and a “silky sensation” in the mouth, said agents containing, in relation to their weight, between 0.001 and 25 wt. % poly(lactic acid) particles, between 0 and 15 wt. % sorbitol and between 0 and 30 wt. % glycerol, with the proviso that the total quantity of ingredient(s) in groups b) and c) lies between 5 and 40 wt. %.
    Type: Application
    Filed: November 18, 2015
    Publication date: March 10, 2016
    Inventors: Thomas Welss, Thomas Foerster, Markus Semrau, Kristin Miehlich, Claudia Hundeiker
  • Publication number: 20160067172
    Abstract: A personal care composition includes a surfactant; and a polymer comprising a hydrophobically modified polyurethane, a hydrophobically modified polyether polyol, or a combination thereof; wherein the personal care composition has a viscosity ranging from about 8,000 cP to about 40,000 cP; and wherein the personal care composition is free of sulfates
    Type: Application
    Filed: September 4, 2015
    Publication date: March 10, 2016
    Applicant: Elementis Specialties, Inc.
    Inventors: Kimberly Burch, Binhua Yang, Timothy Kenny
  • Publication number: 20160067173
    Abstract: The present invention relates to the cosmetic use, as deodorant active agent, of an essential oil of Satureja montana comprising more than 60% by weight of geraniol and more than 5% by weight of trans-?-caryophyllene, in particular of Satureja montana L. ssp. variegata (or Satureja Montana var. citrodoria oil). It also relates to a cosmetic method for treating human body odours, in particular of the armpits or feet, which consists in applying, to human keratin materials, at least one Satureja montana essential oil as defined previously or a composition containing same in a cosmetically acceptable medium.
    Type: Application
    Filed: April 14, 2014
    Publication date: March 10, 2016
    Inventors: Géraldine LEREBOUR, Pierre LARTAUD, Bertrand LACROIX
  • Publication number: 20160067174
    Abstract: The present invention generally relates to compositions and methods for treatment of subjects having or at risk of arteriosclerosis, hypertension, sickle-cell anemia, or other conditions. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto a location with acne, or on another suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
    Type: Application
    Filed: September 22, 2014
    Publication date: March 10, 2016
    Applicant: Transdermal Biotechnology, Inc.
    Inventor: Nicholas V. Perricone
  • Publication number: 20160067175
    Abstract: The present invention relates to an intrathecal (IT) formulation comprising an opioid, a Na channel blocker, an alpha2-receptor agonist, an opioid mu or delta receptor competitive antagonist and an intravenous anesthetic.
    Type: Application
    Filed: September 4, 2015
    Publication date: March 10, 2016
    Inventor: Gilbert BLAISE
  • Publication number: 20160067176
    Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic agent that is poorly soluble in water or an aqueous solvent.
    Type: Application
    Filed: September 2, 2015
    Publication date: March 10, 2016
    Inventors: Zhongli Ding, Guohua Chen, Parminder Singh
  • Publication number: 20160067177
    Abstract: A method (and the resulting product) of making a medical implant device for releasing self-contained drugs on a controlled basis wherein the method utilizes, at least in part, computer-controlled 3-D printing equipment to deposit via nozzles portions of one or more layers of the medical implant product. The implant has an outer impervious coating, an inner matrix core, an opening and an optional bonding layer.
    Type: Application
    Filed: August 10, 2015
    Publication date: March 10, 2016
    Inventors: Robert W. ADAMS, Wayne C. POLLOCK
  • Publication number: 20160067178
    Abstract: Pharmacologically active implants, in particular subcutaneous implants, intrauterine devices, and intravaginal rings, are provided herein. Methods for forming an active ingredient-containing core are described. Methods for laminating an active ingredient-containing core to form a rate-controlling sheath are also described.
    Type: Application
    Filed: September 8, 2015
    Publication date: March 10, 2016
    Applicant: ProMed Pharma, LLC
    Inventors: James H. ARPS, Matthew PETERSEN
  • Publication number: 20160067179
    Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
    Type: Application
    Filed: June 16, 2015
    Publication date: March 10, 2016
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • Publication number: 20160067180
    Abstract: The invention provides a semi-solid chewable dosage form for use as an over-the-counter medication that contains an active pharmaceutical ingredient to treat symptoms associated with allergies, colds, coughs, fever, pain, gastrointestinal disorders, sleep, and other common conditions. The invention further provides a semi-solid chewable dosage form that contains an active pharmaceutical ingredient, a gelling agent, gelatin, sugar, a polyol, and a pH adjusting agent. The invention also provides a semi-solid chewable dosage form that contains a gelling agent, sugar, a polyol, glycerin, and a pH adjusting agent.
    Type: Application
    Filed: September 8, 2015
    Publication date: March 10, 2016
    Applicant: SANTA CRUZ PHARMACEUTICALS, INC.
    Inventors: Michael T. WESTHUSING, Yong BAI, Mario W. MEDRI
  • Publication number: 20160067181
    Abstract: The purpose of the present invention is to provide a technique for formulating a two-layer separation-type ophthalmic solution in which, during storage, an aqueous layer and an oil-containing layer containing squalane are separated from each other, wherein it is possible to homogeneously disperse the oil-containing layer in the aqueous layer while suppressing foaming by shaking the ophthalmic solution before administration, and the homogeneous dispersed state is maintained in a stable manner at least until administration. A two-layer separation-type ophthalmic solution containing squalane and water, wherein hyaluronic acid and/or a salt thereof and polyvinyl alcohol are contained in the ophthalmic solution and the polyvinyl alcohol content is set to 0.025 to 0.
    Type: Application
    Filed: March 18, 2014
    Publication date: March 10, 2016
    Applicant: SENJU PHARMACEUTICAL CO., LTD.
    Inventor: Shirou SAWA
  • Publication number: 20160067182
    Abstract: Materials and methods for treating cancer patients with immunoliposomal chemotherapeutic agents are disclosed. The methods comprise administering to a patient a therapeutically effective amount of an immunoliposome in combination with a chemotherapeutic agent comprising an alkylating agent or an organoplatinum agent. The materials are immunoliposomal chemotherapeutic agents and chemotherapeutic preparations comprising an alkylating agent or an organoplatinum agent, each for use in the disclosed methods.
    Type: Application
    Filed: April 9, 2014
    Publication date: March 10, 2016
    Inventors: ELENA GERETTI, BART S. HENDRIKS, VICTOR MOYO, THOMAS WICKHAM, DARYL C. DRUMMOND, DMITRI KIRPOTIN, WALID KAMOUN
  • Publication number: 20160067183
    Abstract: Disclosed are drug delivery systems for the delivery of small molecule and macromolecular drugs. More particularly, disclosed are substituted analogs of 3,6-di(alkyl-4 aminobutyl)-2,5-diketopiperazine (which may also be referred to DKP), their use in the formulation of both small molecule and macromolecular drugs including therapeutic, prophylactic and diagnostic agents, stabilizing agents and systems for their delivery.
    Type: Application
    Filed: November 18, 2015
    Publication date: March 10, 2016
    Inventor: Kelly Sullivan Kraft
  • Publication number: 20160067184
    Abstract: The present invention relates to improved uses of GLP-1 peptides in oral therapy.
    Type: Application
    Filed: May 2, 2014
    Publication date: March 10, 2016
    Inventors: Flemming S. Nielsen, Per Sauerberg
  • Publication number: 20160067185
    Abstract: [Problem] To provide a solid pharmaceutical composition which contains a compound represented by general formula (1) or a salt thereof and suppresses decomposition of said compound or salt thereof, and a production method of said solid pharmaceutical composition. [Solution] This solid pharmaceutical composition contains a compound represented by general formula (1) or a salt thereof, a cellulosic excipient, and an acidic substance of pH 4.0 or less.
    Type: Application
    Filed: April 24, 2014
    Publication date: March 10, 2016
    Applicant: KYORIN PHARMACEUTICAL CO., LTD.
    Inventors: Hiroshi UCHIDA, Masataka HANADA
  • Publication number: 20160067186
    Abstract: A method of treating a human subject in need of melatonin therapy includes administering to a human subject a compressed tablet comprising melatonin, citric acid, and a cellulosic polymer. The melatonin, citric acid, and cellulosic polymer combine after ingestion to form an acidic hydrogel that dissolves the melatonin and is effective to provide a first release dose of melatonin for assisting in inducement of sleep and a subsequent sustained release dose of melatonin for assisting in sustaining sleep while in the human subject's gastrointestinal tract.
    Type: Application
    Filed: November 16, 2015
    Publication date: March 10, 2016
    Inventors: Syed M. Shah, Daniel Hassan
  • Publication number: 20160067187
    Abstract: The present invention provides a method for treating or preventing one or more types of migraines by administering a monoamine oxidase inhibitor, preferably Isocarboxazid, to a patient without invoking hypertensive crisis.
    Type: Application
    Filed: July 8, 2015
    Publication date: March 10, 2016
    Inventors: Richard A Guarino, Eyal Ron
  • Publication number: 20160067188
    Abstract: A composition for manufacture of hard hydroxypropyl methyl cellulose capsules comprising a film forming material of hydroxypropyl methyl cellulose having a methoxy content of 27.0-30.0% (w/w), and a hydroxypropoxy content of 4.0-7.5% and as a 2% weight solution, a viscosity of 3.5-6.0 cPs at 20° C., dipping compositions, process for manufacture of hard hydroxypropyl methyl cellulose capsules according to a dip coating process and hard capsule shells.
    Type: Application
    Filed: September 21, 2015
    Publication date: March 10, 2016
    Inventors: Dominique Nicolas Cade, David He Xiongwei
  • Publication number: 20160067189
    Abstract: The invention provides coated particles with taste-masked N-acetylcysteine. The particles comprise a core with the active ingredient and a coating comprising a triglyceride and a surfactant. The particles exhibit rapid drug release and a stable release profile. Moreover, the invention provides a hot-melt coating method for manufacturing such particles, and pharmaceutical compositions comprising the particles. The method allows the coating of core particles at moderate temperatures, thereby preventing the degradation of the thermolabile active ingredient.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 10, 2016
    Inventors: Karin BECKER, Detlev HAACK, Sharareh SALAR BEHZADI, Andreas ZIMMER
  • Publication number: 20160067190
    Abstract: A system for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through an injectable nano-network consisting of oppositely-charged dextran nanoparticles encapsulating insulin and glucose-specific enzymes forming a gel-like 3D scaffold. As demonstrated by the examples, the system effectively dissociates to release insulin in a hyperglycemic condition, where the catalytic conversion of glucose into gluconic acid and the subsequent degradation of polymeric matrix are facilitated. This formulation design provides a delivery strategy for both self-regulated and long-term diabetes management.
    Type: Application
    Filed: April 29, 2014
    Publication date: March 10, 2016
    Applicant: The Children's Medical Center Corporation
    Inventors: Daniel G. Anderson, Zhen Gu, Alex Arthur Aimetti, Robert S. Langer
  • Publication number: 20160067191
    Abstract: Methods, systems, and devices are disclosed for encapsulating biological entities with preservation of their biological activity. In one aspect, a method of encapsulating a biological entity includes templating a biocompatible material onto a biological structure to form a coating structure enclosing the biological structure, the coating structure having a size in the nanometer range, in which the coated biological structure preserves its biological activity within the coating structure. In some implementations of the method, the biological structure includes a virus and the biocompatible material includes silica.
    Type: Application
    Filed: April 18, 2014
    Publication date: March 10, 2016
    Inventors: Inanc Ortac, Gen Yong, Michael Benchimol, Sadik C. Esener
  • Publication number: 20160067192
    Abstract: We report for the first time that pterostilbene, a natural analog of resveratrol, shows anxiolytic-like action by downregulating phosphorylated levels of ERKs in the hippocampus of mice. Mice administered pterostilbene (1-10 mg/kg BW) by oral gavage were subjected to the Elevated-plus maze (EPM) test. Pterostilbene manifested anxiolytic activity at 1 and 2 mg/kg doses, demonstrated by an increase in percent permanence time and number of entries in open arms, critical determinants correlated with anxiety. This anxiolytic activity of pterostilbene was comparable to that of diazepam at 1 and 2 mg/kg in the EPM. The percent traveled distance and the percent permanence time in the enclosed arms were decreased with the 1 and 2 mg/kg doses. The 5 and 10 mg/kg doses did not show any anxiolytic effect. Locomotor activity was unaffected in all doses.
    Type: Application
    Filed: May 11, 2011
    Publication date: March 10, 2016
    Inventors: Agnes M. Rimando, Abir El-Alfy, Md Al Rahim
  • Publication number: 20160067193
    Abstract: A chemoprotective method for treating, inhibiting or preventing DNA damage in skin and/or hyperplasia caused by ultraviolet (UV) light by using an effective amount of pterostilbene is provided. Pharmaceutical and nutraceutical compositions containing pterostilbene suitable for administration to an individual in order to prevent subsequent UV-mediated DNA damage and/or hyperplasia in skin are provided.
    Type: Application
    Filed: September 3, 2015
    Publication date: March 10, 2016
    Inventors: Frank L. Meyskens, JR., Ryan W. Dellinger
  • Publication number: 20160067194
    Abstract: A chemoprotective method for treating, inhibiting or preventing loss of barrier function in skin caused by ultraviolet (UV) light by using an effective amount of pterostilbene is provided. Pharmaceutical and nutraceutical compositions containing pterostilbene suitable for administration to an individual in order to prevent subsequent UV-mediated loss of barrier function in skin are provided.
    Type: Application
    Filed: September 3, 2015
    Publication date: March 10, 2016
    Inventors: Frank L. Meyskens, JR., Ryan W. Dellinger