Patents Issued in March 15, 2016
  • Patent number: 9283278
    Abstract: Compositions containing a surface active agent and a sub-lethal amount of an antimicrobial agent and methods for using such compositions are provided herein.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: March 15, 2016
    Assignee: Plurogen Therapeutics, Inc.
    Inventors: George Rodeheaver, Adam Katz
  • Patent number: 9283279
    Abstract: Polymeric conjugates comprising a polymeric backbone having attached thereto a bone targeting moiety and a therapeutically active agent, wherein the bone targeting moiety is attached to one end of the polymeric backbone via a branching unit such that a molar ratio of the bone targeting moiety to the polymer is at least 2:1, are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: March 15, 2016
    Assignees: Ramot at Tel-Aviv University Ltd., Universita degli Studi di Padova
    Inventors: Ronit Satchi-Fainaro, Gianfranco Pasut
  • Patent number: 9283280
    Abstract: The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject, as well as compositions and methods for providing migraine pain relief. The compositions include at least one alkyl glycoside and at least one therapeutic agent, such as a 5-HT receptor agonist, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: March 15, 2016
    Assignee: Aegis Therapeutics, LLC
    Inventor: Edward T. Maggio
  • Patent number: 9283281
    Abstract: A thermal triple-responsive polymer, along with methods of its formation and use, is generally provided. The thermal triple-responsive polymer can comprise poly[(2-(pyridin-2-yldisulfanyl)-co-[poly(ethylene glycol)]-co-[N-isopropyl methacrylamide], which contains both disulfide bonds and ester bonds that are labile to high redox potential and acidic pH, respectively, and temperature sensitive segments. The thermal triple-responsive polymer can be modified with 4-methoxybenzoic acid to endow tumor targeting effect. Nanoparticles and nanogels that include such a thermal triple-responsive polymer are also provided, along with their methods of formation and use.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: March 15, 2016
    Assignee: University of South Carolina
    Inventors: Peisheng Xu, Huacheng He
  • Patent number: 9283282
    Abstract: A polymer and a method for its preparation are provided. The polymer comprises poly(lactide), poly(lactide/glycolide) or poly(lactic acid/glycolic acid) segments bonded by ester linkages to both ends of an alkanediol core unit. The polymer is for use in a controlled release formulation for a medicament, preferably leuprolide acetate. The controlled release formulation is administered to a patient as a subcutaneous depot of a flowable composition comprising the polymer, a biocompatible solvent, and the medicament. Controlled release formulations comprising the polymer release leuprolide for treatment of prostate cancer patients over periods of 3-6 months.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: March 15, 2016
    Assignee: Tolmar Therapeutics, Inc.
    Inventor: Richard L. Dunn
  • Patent number: 9283283
    Abstract: The present invention relates to hydrogels based on hyaluronic acid based derivatives, that are more resistant than hyaluronic acid alone towards chemical and enzymatic degradation and are endowed with a mix of chemical and mechanical properties such that they are of optimal use in several surgeries, for instance for injection in bone fractures or cavities and for the production of coatings of prostheses in orthopedic surgery, as fillers in cosmetic and maxillo-facial surgery, as anti-adhesion barrier in the prevention of postoperative adhesions in abdominal and abdominal/pelvic surgery, and in general surgery. These hydrogels can be loaded with several different kinds of compounds having pharmacological and biological activity, that are then released from the hydrogel in the site of intervention.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: March 15, 2016
    Assignees: MERO S.R.L., NOVAGENIT S.R.L.
    Inventors: Gaetano Giammona, Giovanna Pitarresi, Fabio Palumbo, Carlo Luca Romano′, Enzo Meani, Edgardo Cremascoli
  • Patent number: 9283284
    Abstract: The use is described of a conjugate between hyaluronic acid or a derivative thereof and antitumoral drugs for the preparation of pharmaceutical compositions for the topical treatment of hyperproliferative skin diseases.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: March 15, 2016
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Davide Renier, Susy Panfilo
  • Patent number: 9283285
    Abstract: A nanoparticulate composition is disclosed for the targeted therapeutic treatment of tumors. The stable self assembled nanocomposition according to the invention comprises (i) a carrier and targeting system comprising an optionally modified polyanion, and optionally a polycation, which may also be modified; at least one targeting agent which is linked to either the polycation/modified polycation or the polyanion/modified polyanion, or both or to the surface of the nanoparticle; (ii) an active compound selected from the group of docetaxel and its pharmaceutically acceptable salts and derivatives especially its hydrates, especially docetaxel trihydrate and docetaxel trihydrate monohydrochloride; and optionally (iii) at least one complexing agent, a metal ion and a stabilizer/formulating agent, or a PEGylating agent.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: March 15, 2016
    Assignee: BBS Nanotechnology Ltd.
    Inventors: János Borbély, Zsuzsanna Csikós, Krisztina Kerekes
  • Patent number: 9283286
    Abstract: Disclosed are methods, compositions and uses of conjugates of prodrug forms of 2-pyrrolinodoxorubicin (P2PDox) with antibodies or antigen-binding fragments thereof (ADCs), with targetable construct peptides or with other targeting molecules that are capable of delivering the P2PDox to a targeted cell, tissue or pathogen. Once delivered to the target cell, the ADC or peptide conjugate is internalized, a highly toxic 2-pyrrolinodoxorubicin (2-PDox) is released intracellularly. The P2PDox-peptide or ADC conjugates are of use to treat a wide variety of diseases, such as cancer, autoimmune disease or infectious disease.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: March 15, 2016
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, William J. McBride, Nalini Sathyanarayan, Christine Mazza-Ferreira, David M. Goldenberg
  • Patent number: 9283287
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: March 15, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles, Ron Weiss
  • Patent number: 9283288
    Abstract: In certain aspects, the invention relates to processes for using renally excretable optical agents to detect one or more tissues of the renal system of a surgical patient. In certain aspects, the invention relates to a kit including a biocompatible composition containing one or more optical agents and instructions for using the optical agent(s) in a process of the present invention.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: March 15, 2016
    Assignee: MediBeacon, Inc.
    Inventors: Richard B. Dorshow, Raghavan Rajagopalan, Dennis A. Moore, Scott T. Depierro
  • Patent number: 9283289
    Abstract: Encompassed are pharmaceutically acceptable compositions formulated for the topical or transdermal delivery of probes specific for cyclooxygenase-2 (COX-2) of human and non-human subjects. In particular, an activatable probe comprises a fluorescent moiety comprising a fluorophore attached to a compound having selective affinity for COX-2, and a removable fluorescence quencher linked to the fluorescent moiety by a cleavable linker. Upon delivery to a recipient subject, the activatable probe is localized and concentrated in tissues and cells with elevated levels of COX-2. The linker is cleaved to release the fluorescence quencher.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: March 15, 2016
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIO
    Inventors: Jayakumar Rajadas, Emilio Gonzalez, Hyejun Ra, Irfan Ali-Khan, Christopher Contag
  • Patent number: 9283290
    Abstract: Compositions, articles, and methods for treating and imaging vulnerable plaque and other inflamed regions in a patient rely on delivery of a conversion electron emitting source (CEES) to a body location. The CEES may be delivered by coupling to a substance which preferentially binds to vulnerable plaque or other inflammatory marker. Alternatively, the CEES can be delivered on a catheter, scaffold, or other device.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: March 15, 2016
    Inventors: Gilbert R. Gonzales, Nicholas Chronos
  • Patent number: 9283291
    Abstract: The present invention relates to a method for preparing a radiolabeled macromolecule, the method comprising contacting a macromolecule with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous medium comprising a pH selected to promote short-range attractive forces between the nanoparticles and the macromolecule by attenuating repulsive electrostatic forces.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: March 15, 2016
    Assignee: The Australian National University
    Inventors: Ross Wentworth Stephens, Timothy John Senden, David Wallace King
  • Patent number: 9283292
    Abstract: A device (1; 26) for use in a medical treatment room includes at least one control unit (2, 6; 18) designed as a light guide and at least one light source (3, 3?; 21) which emits light with a wavelength between 380 nanometers and 420 nanometers, particularly 405 nanometers, and is arranged in such a manner that emitted light is coupled into the light guide. The light guide is designed in such a manner that light exiting the light guide again at least partially illuminates the surface of the control unit (2, 6; 18).
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: March 15, 2016
    Assignee: Drägerwerk AG & Co. KGaA
    Inventor: Hanno Kretschmann
  • Patent number: 9283293
    Abstract: A method for pasteurizing a continuous product chain in a device having an inlet, heat-up, pasteurization, and cooling regions all divided into treatment zones, and a transporter for passing products through these regions includes heating up, pasteurizing, and cooling by heat transfer between the products and a spray medium with which the products are sprayed, for each of the treatment zones, adapting a temperature of the spray medium to cause a desired consequence to heat transfer in the treatment zone, and varying a pasteurization process by changing a volumetric flow rate of the spray medium in at least one treatment zone between a maximum value and a minimum value.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: March 15, 2016
    Assignee: KHS GmbH
    Inventors: Andre Ratke, Thomas Stienen
  • Patent number: 9283294
    Abstract: A manual contact device including an antimicrobial contact surface, wherein the antimicrobial contact surface includes sodium chloride. A method for reducing a transfer of microorganisms by manual contact with a manual contact device, including providing the manual contact device with an antimicrobial contact surface, wherein the antimicrobial contact surface includes sodium chloride.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: March 15, 2016
    Assignee: OUTBREAKER SOLUTIONS INC.
    Inventor: Douglas Glenn Olson
  • Patent number: 9283295
    Abstract: The present invention relates to an add on filter and air filtration system and method incorporating an add on filter for applying ultraviolet light to an environment to create oxidizing agents for killing microbes, such as bacteria, mold, and viruses, and for destroying odors. The add on filter may be coupled to existing air filtration systems to provide further filtration of the air. The add on filter includes an ultraviolet light source for emitting a broad spectrum of ultraviolet light and a catalytic target structure mechanically coupled to the ultraviolet light source. The system and method result in the production of Hydroxyl Radicals, Super Oxide ions and Hydro Peroxide for killing microbes.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: March 15, 2016
    Assignee: RGF ENVIRONMENTAL GROUP, INC.
    Inventors: Ronald G. Fink, Walter B. Ellis
  • Patent number: 9283296
    Abstract: A scent producing apparatus constituted of: a control circuitry; a plate exhibiting at least one release port extending from a first face of the plate to a second face of the plate opposing the first face; at least one scent reservoir in communication with the first face of the plate; a controllable scent release mechanism associated with each scent reservoir and arranged to release a controlled quantity of the contents of the associated scent reservoir through a release port to the second face of the plate; and a vibrator responsive to the control circuitry and in communication with the plate, wherein the control circuitry is arranged to: control each controllable scent release mechanism to release a controlled quantity of the contents of the associated scent reservoir through the release port to the second face of the plate; and vibrate the plate to thereby atomize the released contents.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: March 15, 2016
    Assignee: SCENTCOM, LTD.
    Inventors: Yossi Haran, Tsafrir Sasson, Joseph Slupsky
  • Patent number: 9283297
    Abstract: A sanitary article (1) such as a sanitary napkin, a panty liner, an incontinence protector, a diaper, an incontinence pad, a feminine insert, a tampon, or the like includes a top sheet (2) and a microbe-inhibiting composition (8). The microbe-inhibiting composition (8) includes at least one extracellular product of at least one probiotic bacterium and/or at least one probiotic bacterium and at least one additive in the form of an organic acid, with at least one of its pKa value not exceeding 5.5, and/or a salt thereof.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: March 15, 2016
    Assignee: SCA HYGIENE PRODUCTS AB
    Inventors: Ulrika Husmark, Ulla Forsgren Brusk
  • Patent number: 9283298
    Abstract: Surgical adhesives that include a blend of two different thermoreversible gelling polymers and a crosslinking agent are described. The first thermoreversible gelling polymer is partially or fully acrylated and the second thermoreversible gelling polymer includes dual functionality including acrylate functionality and amine-reactive functionality. The adhesives can provide gelling and covalent crosslinking within the polymers of the adhesive as well as crosslinking with surrounding tissue.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: March 15, 2016
    Assignee: Clemson University
    Inventors: Jiro Nagatomi, C. Kenneth Webb, Olin Thompson Mefford, Lindsey Sanders, Roland Stone
  • Patent number: 9283299
    Abstract: The present disclosure generally relates to injectable compositions. More particularly, the present disclosure relates to injectable, thermogelling hydrogels and associated methods. In one embodiment, the present disclosure provides for a composition comprising a poly(N-isopropylacrylamide)-based macromer and a polyamidoamine-based macromer.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: March 15, 2016
    Assignee: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Antonios G. Mikos, F. Kurtis Kasper, Adam K. Ekenseair, Tiffany N. Vo, Kristel W. M. Boere, Tyler J. Touchet
  • Patent number: 9283300
    Abstract: The applications and medical devices of Midkine in the field of biotechnology are described in this invention. This invention describes the applications of the protein as follow in (a) or (b) in preparing drugs for promoting cartilage growth or treating cartilage diseases, the protein as a growth factor for promoting chondrocyte proliferation, or medical devices containing this protein: (a) the protein whose amino acid sequence is shown as SEQ ID NO.1; (b) the proteins whose amino acid sequence have at least 60% homology comparing with amino acid sequence described in (a). The present invention is different from the present knowledge of MK and its related proteins. The experimental results demonstrated that MK promotes proliferation of three types of chondrocytes and is used for preparing drugs for treating cartilage disease. It may provide new therapy for treating cartilage diseases clinically, and new technology for expansion of chondrocytes in vitro for cartilage tissue engineering.
    Type: Grant
    Filed: May 25, 2010
    Date of Patent: March 15, 2016
    Assignee: GENERAL REGENERATIVES, LTD
    Inventors: Wei Han, Zhonghui Zhang
  • Patent number: 9283301
    Abstract: A hydrogel biomaterial that can be utilized as a nucleus pulposus replacement material is described. The hydrogel biomaterial can is an elastin-glycosaminoglycan-collagen composite hydrogel biomaterial that can mimic the biochemical and functional characteristics of the human nucleus pulposus. Methods for forming the hydrogel biomaterial are also described as are methods for use of the hydrogel biomaterial, one of which is as an in vivo nucleus pulposus replacement material, another of which is a scaffolding material for use in nucleus pulposus tissue engineering applications.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: March 15, 2016
    Assignee: Clemson University
    Inventors: Dan Simionescu, Jeremy J. Mercuri
  • Patent number: 9283302
    Abstract: A remodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region and at least one lead conduit, the internal region being configured to receive a device therein, the lead conduit being configures to receive at least one device lead therein, the bioremodelable material comprising an extracellular matrix (ECM) composition that includes an ECM component derived from a mammalian source.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: March 15, 2016
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9283303
    Abstract: A surgical implant comprising: a substrate having an exterior surface and a plurality of layers disposed over the substrate exterior surface. The substrate comprises a polymeric material, and the plurality of layers comprises: an activated substrate surface layer; a valve metal layer; and a porous valve metal oxide layer, wherein the valve metal layer is disposed between the activated substrate layer and the porous valve metal oxide layer. The disclosure provides for a method for producing a polymeric surgical implant. The exterior substrate surface is treated by one or more processes comprising: plasma activation; electron beam irradiation; ultraviolet light; and low energy Ar+ ion beam irradiation; producing an activated substrate surface layer. A plurality of layers is applied over the activated substrate surface layer. The surface is converted by a spark-anodization process in an alkaline bath containing Ca and P ions into a layer of porous valve metal oxide.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: March 15, 2016
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Cyril Voisard, Philippe Gédet, Nicolas Bouduban
  • Patent number: 9283304
    Abstract: A biocompatible metallic material may be configured into any number of implantable medical devices, including intraluminal stents. The biocompatible metallic material may comprise a magnesium alloy. The magnesium alloy implantable medical device may be designed to degrade over a given period of time. In order to control the degradation time, the device may be coated or otherwise have affixed thereto one or more coatings, one of which comprises a material for controlling the degradation time and maintain a pH neutral environment proximate the device. Additionally, therapeutic agents may be incorporated into one or more of the coatings on the implantable medical device.
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: March 15, 2016
    Assignee: CARDINAL HEALTH SWITZERLAND 515 GmbH
    Inventor: Jonathon Z. Zhao
  • Patent number: 9283305
    Abstract: A method of a forming a hollow, drug-eluting medical device includes providing composite member having an outer member and a core member disposed within a lumen of the outer member. The composite member is shaped into a pattern. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from the lumen of the outer member without harming the outer member, leaving a hollow tubular member already formed into the desired pattern. The lumen of the outer member is filled with a therapeutic substance.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: March 15, 2016
    Assignee: Medtronic Vascular, Inc.
    Inventors: Matthew J. Birdsall, Christopher Storment, D. H. Perkins, Dustin Thompson
  • Patent number: 9283306
    Abstract: Since a medium having light propagation properties and sound propagation properties similar to those of human tissues is provided, reflection of light and an acoustic wave at a surface of a test portion is prevented, and accuracy control of a photoacoustic wave diagnostic apparatus is realized. A photoacoustic matching material is provided which includes a polyol, an inorganic oxide, and a pigment, the latter two being dispersable in the polyol, and in this photoacoustic matching material, a dispersed amount of the inorganic oxide to the polyol is in a range of 0.10 to 0.25 percent by weight, and a dispersed amount of the pigment to the polyol is in a range of 0.0001 to 0.0005 percent by weight.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: March 15, 2016
    Assignee: Canon Kabushiki Kaisha
    Inventors: Takahiro Suita, Takuji Oishi
  • Patent number: 9283307
    Abstract: Methods and devices for treatment of damaged tissue are disclosed, including treatment of wounds by employing non-electrically powered, reduced pressure therapy devices. Maintenance and control of the sub atmospheric pressure exerted may be provided by such devices while minimizing discomfort to the user. The devices may be configured to be worn inconspicuously underneath clothing.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: March 15, 2016
    Assignee: KCI Licensing, Inc.
    Inventors: Dean Hu, Moshe Pinto, Kenton Fong
  • Patent number: 9283308
    Abstract: A suction tip for a surgical instrument includes a hollow housing having a top flat wall and a bottom flat wall and including a proximal end and a distal end. The distal end has a widened tip portion that is wider than the proximal end. The distal end may have a plurality of suction ports located at its front, top, right side and left side of the widened tip portion. Furthermore a ledge portion may protrude outwardly past a terminal end of the top flat wall to provide a clear space between the suction ports and tissue for evacuation of fluid in the clear space. Furthermore, the ledge portion which protrude outwardly may have bended tip in desire degrees and shapes.
    Type: Grant
    Filed: August 21, 2013
    Date of Patent: March 15, 2016
    Inventors: Hamid Cyrus Hajarian, Vahid Hamidi
  • Patent number: 9283309
    Abstract: A device for supplying energy to hydraulically or pneumatically actuated active implants. The device can take the form of pumping systems, metering systems, and/or occlusion systems. The device comprises a receiving coil for generating an electric voltage due to a changing magnetic flux that is generated by an extracorporeal transmitting coil. The receiving coil is designed such that said coil can be implanted into subcutaneous tissue. Furthermore, an electric line is provided for transmitting the electric current that is generated by the receiving coil from the receiving coil to the active implant. The device further comprises a compensation container for temporarily receiving a transmitter fluid, by means of which the active implant is activated. The compensating container is mounted on the receiving coil and/or on the electric line such that the compensating container together with the receiving coil and/or the electric line can be implanted into a common tissue or muscle pocket in the body of a patient.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: March 15, 2016
    Assignee: Deutsches Zentrum Fuer Luft-Und Raumfahrt E.V.
    Inventors: Thomas Schmid, Bernhard Vodermayer, Cornelia Riecke, Annika Rybak, Matthias Grzeski
  • Patent number: 9283310
    Abstract: In an extracorporeal blood treatment apparatus, a user interface (22) has a touch screen for displaying two bar-graphs (24) of pressures in the extracorporeal blood circuit. By touching a bar-graph three alpha-numeric values appear: a reference value (29), an upper safety interval (28) of the pressure, comprised between an upper limit value and the reference valve (29), and a lower interval value (30), comprised between the reference value and a lower limit value. The reference value is a measured pressure value. Four buttons also appear on the display for input of modifications to the upper interval and the lower interval. The setting of the total pressure safety interval is simple and immediate.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: March 15, 2016
    Assignee: GAMBRO LUNDIA AB
    Inventors: Michel Royer, Fabio Roncadi
  • Patent number: 9283311
    Abstract: An oxygenator includes: a housing; a hollow fiber membrane bundle stored in the housing and having multiple integrated hollow fiber membranes with a gas exchange function; a gas inlet portion and a gas outlet portion provided on the upstream and downstream of gas passages in lumens of the hollow fiber membranes, respectively; a blood inlet portion and a blood outlet portion provided on the upstream and downstream of blood passages outside the hollow fiber membranes, respectively; a first filter member provided on the hollow fiber membrane bundle in contact with a blood outlet portion side surface so as to cover substantially the entire surface and has a function to catch bubbles in blood; and a second filter member that is separated from the first filter member, positioned between the first filter member and the blood outlet portion, and has a function to catch bubbles in blood.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: March 15, 2016
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Kazuhiko Takeuchi
  • Patent number: 9283312
    Abstract: A peritoneal dialysis system includes a disposable cassette including a flexible sheet; a hardware unit including (i) at least one pump actuator and piston head moved by the pump actuator, (ii) at least one valve actuator, (iii) at least one sensor, and (iv) a disposable cassette interface for interfacing with the disposable cassette, the disposable cassette interface including: (a) at least one pump aperture, the at least one piston head moveable out of and retractable into the at least one pump aperture to move a corresponding pumping portion of the flexible sheet of the disposable cassette, the piston head moving within a vacuum chamber, the vacuum chamber enabling a vacuum to be pulled around the piston head to the flexible sheet of the disposable cassette; (b) at least one valve aperture, at least a portion of the at least one valve actuator located in the valve aperture to move a valve portion of the flexible sheet of the disposable cassette; and (c) at least one sensor aperture, the at least one sensor
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: March 15, 2016
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Robert W. Childers, Richard Avoy, John Booras, Joseph H. Bowman, Jr., Paul Grippo, Andrew D. Hopping, David Howard, Jeffrey W. Jerrell, Benjamin Kellam, Brian Lauman, Sherwin Shang, David Vescovi, Tahua Yang, Alex Yu
  • Patent number: 9283313
    Abstract: A multi-part device for separating plasma from whole blood is provided, with a sample taking unit for receiving whole blood, a filter unit with a layered filter with multiple layers for extracting plasma, and a pumping unit, typically a plunger pump, for creating a partial vacuum in the filter unit. The filter unit and a plasma collector vessel with a conical tip extending towards the filter unit are contained in a filter cartridge, which may be taken apart after plasma extraction, thus exposing the conical tip of the plasma collector vessel for sample input into an analyzer.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: March 15, 2016
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Herfried Huemer
  • Patent number: 9283314
    Abstract: Systems and methods for coupling devices such as a ventricular assist device to vascular tissues, such as a heart. In one version, a method is provided for attaching a device to vascular tissue for fluid flow. The device includes a cannula coupled to a cuff, and the method includes coupling the cuff to the vascular tissue, penetrating the vascular tissue by inserting a penetration device through the cannula, and inserting a first end of the cannula through the cuff and into the vascular tissue.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: March 15, 2016
    Assignee: ABIOMED, INC.
    Inventors: Jayanthi G. Prasad, Farhad Zarinetchi, Emmanuel N. Ilongo
  • Patent number: 9283315
    Abstract: Apparatus and method for non-invasively determining the level of a constituent of a patient's blood drawn though an elastomeric tubing to a dialysis machine deforms the tubing in the slot of a measuring head having two points of different transverse length with a transmit/receive sensor at each point that transmits a signal through the tubing and the blood and is reflected back to it from the tubing internal wall. The round trip transit time of the signal at each sensor is measured and the blood sound velocity is calculated from the two round trip transit times and the differential of the transverse lengths at the two points. Blood hematocrit level, which is related to blood volume, is calculated from the calculated sound velocity and an empirical relationship.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: March 15, 2016
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventor: Naim Dam
  • Patent number: 9283316
    Abstract: Methods and devices are described for reducing anticoagulant dilution of collected blood components during blood collection.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: March 15, 2016
    Assignee: GRIFOLS, S.A.
    Inventor: Greg Flexman
  • Patent number: 9283317
    Abstract: Disclosed embodiments for assessing brown adipose tissue use imaging of metabolic contrast agents. For example, activated brown adipose tissue may be assessed by evaluating a difference in production of the hyperpolarized 13C metabolic contrast agent from a pre-polarized 13C metabolic contrast agent precursor before and after exposure of the subject to an activating event or agent. In one embodiment, the subject is given a dose of norepinephrine, and the production of the hyperpolarized 13C metabolic contrast agent before and after the dose is assessed.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 15, 2016
    Assignee: General Electric Company
    Inventors: Angus Zoen Lau, Albert Po-Fu Chen, Charles H. Cunningham
  • Patent number: 9283318
    Abstract: A sealing assembly for a fluid infusion device includes a base plate, a reservoir port receptacle, a flow base component, and a needle sealing element. The receptacle receives the reservoir port, and has proximal and distal ends, and a needle entry in the distal end to receive a hollow needle of a fluid reservoir. The flow base component has an inlet structure defining a fluid chamber, and a needle guide pin protruding therefrom. The end of the guide pin fits within the hollow needle. The needle sealing element has a proximal flange adjacent to the inlet structure, a distal flange opposite the proximal flange, a neck section between the flanges, and a needle opening extending through the neck section. The needle sealing element is positioned within the port receptacle such that the neck section surrounds the end section of the needle guide pin.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: March 15, 2016
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Matthew William Yavorsky, Edgardo C. Halili, Eric M. Lorenzen
  • Patent number: 9283319
    Abstract: Cannula assemblies with pressure sensors made of stacked coplanar layers and ambulatory infusion systems comprising the same are disclosed. The cannula assemblies include a hub and an infusion cannula. The hub includes a pressure sensor and a fluid channel fluidly coupled to the infusion cannula. The pressure sensor is formed from a stack of coplanar layers including a top layer, a base layer an electrode layer and a counter electrode layer. The fluid channel is positioned between the top layer and the base layer. The electrode layer is positioned between the top layer and the base layer and coupled to the fluid channel. The counter-electrode layer is positioned between the top layer and the electrode layer. A spacer layer having a through cut-out defining an electrode cavity is disposed between the top layer and the base layer such that the electrode layer extends across the electrode cavity.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: March 15, 2016
    Assignee: ROCHE DIAGNOSTICS INTERNATIONAL AG
    Inventors: Andreas Geipel, Florian Kuhni, Christoph Huwiler, Ulrich Haueter
  • Patent number: 9283320
    Abstract: The disclosed subject matter includes a structure and method for making a dual-lumen needle from single lumen needles to take advantage of the much higher economies of scale. Variations include two needles joined by a flow junction and one needle and a single cannula joined by a flow junction. In addition disclosed are methods of using a dual-lumen needle in a two needle access for blood treatment is disclosed in which at least venous flow is provided through a dual-lumen needle with arterial flow just sufficient to provide air infiltration detection in the event of withdrawal of the dual-lumen needle.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: March 15, 2016
    Assignee: NXSTAGE MEDICAL, INC.
    Inventors: James M. Brugger, Jeffery H. Burbank
  • Patent number: 9283321
    Abstract: A system for recording the wasting of fluids includes a waste disposal unit and a sensor system, having a sensor. The sensor can have one or more sensor elements in fluid communication with a fluid as it is wasted from a container into the waste disposal unit. The sensor system is configured to identify one or more drugs within the fluid and record the identity of the one or more drugs in a computer-readable medium electrically coupled to the sensor system.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: March 15, 2016
    Assignee: Becton, Dickinson and Company
    Inventors: Elizabeth Nelson, Bart D. Peterson, William R. Marshall, Bryan G. Davis
  • Patent number: 9283322
    Abstract: In various embodiments, actuation of a drug-delivery pump is controlled based on a change in a condition of the pump.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: March 15, 2016
    Assignee: MiniPumps, LLC
    Inventors: Jason Shih, Jeffrey Brennan, Fukang Jiang, Sean Caffey
  • Patent number: 9283323
    Abstract: The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimizing the gain factor based on the historical data in relation to the patient.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: March 15, 2016
    Assignee: GENE ONYX LIMITED
    Inventors: Christofer Toumazou, Pantelis Georgiou, Pau Herrero Vinas, Calvin Sim
  • Patent number: 9283324
    Abstract: Fluid transfer devices for use in manual cartridge filling procedures for filling cartridges with liquid drug dosages from medicament containing vials. The fluid transfer devices include a double ended main body having a longitudinal axis, a vial port for telescopic receiving a drug vial and a cartridge port for slidingly receiving a leading cartridge end. The cartridge port includes a cartridge securing arrangement for releasably securing a leading cartridge end therein and a cartridge ejection arrangement for at least partially ejecting a cartridge therefrom for assisting manual sliding ejection of a filled cartridge. The cartridge port can include either a combined cartridge securing and ejection arrangement or a discrete cartridge securing arrangement and a discrete cartridge ejection arrangement.
    Type: Grant
    Filed: April 7, 2013
    Date of Patent: March 15, 2016
    Assignee: Medimop Medical Projects, Ltd
    Inventors: Nimrod Lev, Niv Ben Shalom
  • Patent number: 9283325
    Abstract: The present invention relates to a medicament delivery device comprising a housing (10,12), capable of containing a medicament container (14), a plunger rod (18) and a drive member (34) arranged to said plunger rod and capable of acting on said plunger rod (18) for moving it in the proximal direction of the device for expelling a dose of medicament from said medicament container (14), a dose and drive setting mechanism (52) comprising a dose setting member (56) operably connected to a force member (82) such that setting of a dose causes said force member (82) to be energized. The intermediate member (68) is configured to interact with a dose setting sleeve (50) through a first unidirectional connection (64, 62), configured to interact with said drive member (34) through a second unidirectional connection (70, 72), and configured to interact with a dose drive sleeve (76) through a third connection (74,78).
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: March 15, 2016
    Assignee: SHL Group AB
    Inventor: Anders Karlsson
  • Patent number: 9283326
    Abstract: The invention refers to an auto-injector and to a method for operating it, the auto-injector comprising of a tubular chassis; a carrier subassembly comprising a tubular carrier slidably arranged in the chassis, the carrier containing a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe; a wrap-over trigger sleeve arranged over the distal end (D) of the auto-injector; the trigger sleeve extending at least almost over the whole length of the auto-injector; a control spring arranged around the carrier; first interlock means for coupling a proximal end of the control spring to either the carrier for advancing it for needle insertion or to the chassis for needle retraction; second interlock means arranged for releasing the drive spring for injection; third interlock means arranged for coupling the chassis to the carrier for joint axial translation relative to the trigger sleeve; and fourth interlock means arranged for coupling a
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: March 15, 2016
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Thomas Mark Kemp, Matthew Ekman
  • Patent number: 9283327
    Abstract: According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe; a syringe retainer slidably arranged with respect to the housing that mounts a pre-filled syringe with an injection needle, a plunger and a stopper for sealing a syringe barrel of the pre-filled syringe; a coupling shroud slidably arranged within the housing and releasably coupled to the plunger; and a single drive means. Upon release, the single drive means is capable of driving the coupling shroud in the proximal direction (P).
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: March 15, 2016
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Yannick Hourmand, Timothy Donald Barrow-Williams, Matthew Ekman