Patents Issued in March 15, 2016
  • Patent number: 9284233
    Abstract: A method for manufacturing a pelletized fertilizer includes the following steps. A water-soluble manure and a colloidal solution are mixed, to form an aqueous solution of a fertilizer, wherein the water-soluble manure is selected from the group consisting of monopotassium phosphate, epsomite, manganous sulfite, boric acid, borax, copper sulfate pentahydrate, white vitriol, ammonium molybdate, urea, ferric ethylenediaminetetraacetic acid and potassium nitrate, the colloidal solution is selected from the group consisting of agar, xanthan gum, shellac, guar gum, natto gum, pectin, synthetic hydrogel and PLGA, and the weight percentage of the colloidal solution in the aqueous solution of the fertilizer is between 1.5 and 15%. The aqueous solution of the fertilizer is added into a water within a temperature range between 0 and 4° C., whereby the aqueous solution of the fertilizer is solidified to the pelletized fertilizer.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: March 15, 2016
    Assignee: CHUNGHWA PICTURE TUBES, LTD.
    Inventors: Chou-Chiang Kuo, Min-Lun Wu, Che-Wei Chang
  • Patent number: 9284234
    Abstract: Provided is a gasoline production device capable of effectively using heat of reaction generated in the synthesis of gasoline and also capable of readily cooling heat generated by synthesizing gasoline. A device 30 for producing gasoline from methanol includes a plurality of reaction tubes 34 configured to synthesize gasoline from methanol and a duct 36 configured to allow air to flow outside the reaction tubes, and heat exchange is carried out between synthesis heat generated within the reaction tubes 34 and the air which flows through the duct 36.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: March 15, 2016
    Assignee: MITSUBISHI HEAVY INDUSTRIES, LTD.
    Inventor: Masaki Iijima
  • Patent number: 9284235
    Abstract: The present invention provides a process for methanol coupled catalytic cracking reaction of naphtha using a modified ZSM-5 molecular sieve catalyst, comprising performing a co-feeding reaction of methanol and naphtha on the modified ZSM-5 molecular sieve catalyst to produce low carbon olefins and/or aromatic hydrocarbons. In the process, the modified ZSM-5 molecular sieve catalyst comprises, in term of weight percent, 25-80 wt % of a ZSM-5 molecular sieve, 15-70 wt % of a binder, and 2.2-6.0 wt % of lanthanum and 1.0-2.8 wt % of phosphorus loaded on the ZSM-5 molecular sieve. The naphtha comprises 63.8-89.5 wt % of saturated chain alkanes and 5.6-29.8 wt % of cyclic alkanes. The naphtha and methanol concurrently pass through the catalyst bed, which are reacted during contacting with the catalyst under a reaction condition of a reaction temperature of 550-670° C., a mass ratio of methanol to naphtha of 0.05-0.8, and a total mass space velocity of naphtha and methanol of 1.0-5 h?1.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: March 15, 2016
    Assignee: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Zhongmin Liu, Yingxu Wei, Yue Qi, Mao Ye, Mingzhi Li, Bing Li, Xiangao Wang, Changqing He, Xinde Sun
  • Patent number: 9284236
    Abstract: A process is described for treating a natural gas stream containing methane and one or more higher hydrocarbons including the steps of: (i) mixing at least a portion of the natural gas stream with steam, (ii) passing the mixture adiabatically over a supported precious metal reforming catalyst to generate a reformed gas mixture comprising methane, steam, carbon dioxide, carbon monoxide and hydrogen, (iii) cooling the reformed gas mixture to below the dew point to condense water and removing the condensate to provide a de-watered reformed gas mixture, and (iv) passing the de-watered reformed gas mixture through an acid gas recovery unit to remove carbon dioxide and at least a portion of the hydrogen and carbon monoxide, thereby generating a methane stream. The methane stream may be used to adjust the composition of a natural gas stream, including a vaporized LNG stream, to meet pipeline specifications.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: March 15, 2016
    Assignee: Johnson Matthey PLC
    Inventor: Stephen John Catchpole
  • Patent number: 9284237
    Abstract: Methods and apparatuses for processing hydrocarbons are provided. In one embodiment, a method for processing hydrocarbons includes providing a stream of olefins including normal olefins and non-normal olefins. The method includes separating the normal olefins from the non-normal olefins to form a stream of normal olefins. Further, the method polymerizes the stream of normal olefins to form a stream of polymerized normal olefins. The method also includes saturating the stream of polymerized normal olefins to form a stream of normal paraffins.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: March 15, 2016
    Assignee: UOP LLC
    Inventors: Chad R. Huovie, Charles P. Luebke
  • Patent number: 9284238
    Abstract: The present invention relates to a method for purification of a hydrocarbon stream containing linear alpha olefins, isomers thereof and at least one organic amine, the linear alpha olefins, isomers and the amine having boiling points under atmospheric pressure which differ by at most 5° C., comprising the step of removing a major amount of the organic amine from the hydrocarbon stream by distillation, wherein the distillation is carried out to that, together with the amine, between 5% and 95 wt % of the isomers, based on the total amount of the isomers in the hydrocarbon stream, are removed from the hydrocarbon stream in an amine/isomer-rich fraction.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: March 15, 2016
    Assignees: SAUDI BASIC INDUSTRIES CORPORATION, LINDE AG
    Inventors: Wolfgang Müller, Marco Harff, Anton Wellenhofer, Anina Wöhl, Heinz Bölt, Andreas Meiswinkel
  • Patent number: 9284239
    Abstract: Processes for the production of chlorinated alkanes are provided. The present processes comprise catalyzing the chlorination of a feedstream comprising one or more alkanes and/or alkenes with a catalyst system comprising one or more inorganic iodine salts and/or lower than conventional levels of elemental iodine and at least one Lewis acid. The processes are conducted in a nonaqueous media, and so, the one or more inorganic iodine salts are recoverable and/or reusable, in whole or in part.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: March 15, 2016
    Assignee: BLUE CUBE IP LLC
    Inventors: Matthew L. Grandbois, Xiaoyun Chen, William J. Kruper, Jr.
  • Patent number: 9284240
    Abstract: The present invention provides a process of catalytic fluorination in gas phase of product 1,1,1,2,3-pentachloropropane or/and 1,1,2,2,3-pentachloropropane into product 2-chloro-3,3,3-trifluoropropene in presence of a catalyst and oxygen.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: March 15, 2016
    Assignee: Arkema France
    Inventors: Philippe Bonnet, Anne Pigamo, Laurent Wendlinger, Nicolas Doucet
  • Patent number: 9284241
    Abstract: A method for removing a contaminant from a hydrochlorofluoroolefin (such as trans-1,1,1-trifluoro-3-chloro-2-propene (1233zd(E))) includes extracting a chlorofluorocarbon (such as trichlorofluoromethane (R11)) from a mixture comprising the hydrochlorofluoroolefin and the chlorofluorocarbon using extractive distillation in the presence of an extractive solvent comprising a chlorinated compound to form a purified hydrochlorofluoroolefin. This separation method provides for removal of a contaminant, such as R11, from a hydrochlorofluoroolefin, such as 1232zd(E), which are not separable by conventional distillation methods. The method may employ a process utilizing two distillation columns, for example, a first extractive distillation column and a second solvent recovery column, which allows for recycle of the extractive solvent to the first extractive distillation column.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: March 15, 2016
    Assignee: Arkema Inc.
    Inventor: John A. Wismer
  • Patent number: 9284242
    Abstract: Digestion of cellulosic biomass solids may be complicated by release of lignin therefrom. Methods for digesting cellulosic biomass solids may comprise: providing cellulosic biomass solids in a digestion solvent; at least partially converting the cellulosic biomass solids into a phenolics liquid phase comprising lignin, an aqueous phase comprising an alcoholic component derived from the cellulosic biomass solids, and an optional light organics phase; combining at least the phenolics liquid phase and the aqueous phase with one another, thereby forming a combined phase; and separating at least a portion of the alcoholic component from at least a portion of the combined phase.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: March 15, 2016
    Assignee: Shell Oil Company
    Inventors: Joseph Broun Powell, Kimberly Ann Johnson, Glenn Charles Komplin, Edward James Denton
  • Patent number: 9284243
    Abstract: Subject of the invention is a process for the production of methylbutynol, wherein the process comprises at least one pervaporation step. In a preferred embodiment, the process comprises the steps of (a) providing a feed composition comprising methylbutynol and water, (b) subjecting the feed composition to distillation in a distillation device, (c) removing a sidestream from the distillation device, the sidestream having a higher water content than the feed composition, and (d) subjecting said sidestream to pervaporation, thereby reducing the water content. The invention also relates to uses and devices relating to the inventive process.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: March 15, 2016
    Assignee: LONZA LTD
    Inventors: Stefan Ottiger, Thomas Scholl, Stefan Stoffel, Klaus Kalbermatter, Andreas Klein, Kishore Nedungadi
  • Patent number: 9284244
    Abstract: A method and system for precipitation and separation of carboxylic acid salts from a hydrate inhibitor solution is disclosed. The method comprises lowering the solubility of the carboxylic acid salts to force precipitation of carboxylic acid salts and separation of the precipitated carboxylic acid salts from the hydrate inhibitor solution.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: March 15, 2016
    Assignee: FJORDS PROCESSING AS
    Inventor: Salim Deshmukh
  • Patent number: 9284245
    Abstract: A monomer for a hardmask composition represented by the following Chemical Formula 1,
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: March 15, 2016
    Assignee: CHEIL INDUSTRIES, INC.
    Inventors: Sung-Jae Lee, Hwan-Sung Cheon, Youn-Jin Cho, Chul-Ho Lee, Chung-Heon Lee
  • Patent number: 9284246
    Abstract: A method for producing an optically active 2,3-dihydrofarnesal of formula (1) is disclosed.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: March 15, 2016
    Assignee: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Hideo Ujihara, Mitsuhiko Fujiwhara
  • Patent number: 9284247
    Abstract: The invention relates to a method for producing at least one alkoxy-hydroxybenzaldehyde (AHBA) from at least one hydroxyphenol (HP), said method being characterized in that it comprises the formation of at least one alkoxyphenol (AP) and alkyl-alkoxyphenol (AAP) and the separation (S) of AP from AAP, said separation (S) being carried out prior to obtaining AHBA.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: March 15, 2016
    Assignee: Rhodia Operations
    Inventors: Laurent Garel, Hubert Gayet
  • Patent number: 9284248
    Abstract: A production process of an ?-fluoroaldehyde according to the present invention includes reaction of an ?-fluoroester with hydrogen gas (H2) in the presence of a ruthenium complex. It is possible in the present invention to allow relatively easy industrial production of the ?-fluoroaldehyde and to directly obtain, as stable synthetic equivalents of the ?-fluoroaldehyde, not only a hydrate (as obtained by conventional techniques) but also a hemiacetal that is easy to purify and is of high value in synthetic applications. The present invention provides solutions to all problems in the conventional techniques and establishes the significantly useful process for production of the ?-fluoroaldehyde.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: March 15, 2016
    Assignee: Central Glass Company, Limited
    Inventors: Akihiro Ishii, Takashi Ootsuka, Mari Imamura, Takayuki Nishimiya, Kazuto Kimura
  • Patent number: 9284249
    Abstract: The present invention provides a method of extracting an asymmetric ?-diketone compound from a ?-diketone compound containing at least one symmetric ?-diketone compound mixed in the asymmetric ?-diketone compound, and the method includes the step (A) of adjusting a pH of a mixed solution of the ?-diketone compound and water at 11.5 or more and dissolving the ?-diketone compound into water to form a ?-diketone compound solution and the step (B) of subsequently adjusting the pH of the ?-diketone compound solution at 9.5 or less and recovering the asymmetric ?-diketone compound of Chemical Formula 1 separated from the ?-diketone compound solution. The present invention further includes at least either (a) a step of setting the upper limit of the pH of the mixed solution to 12.5 to form a ?-diketone compound solution in the step (A) and bringing the ?-diketone compound solution into contact with a hydrophobic solvent or (b) a step of setting the lower limit of the pH of the ?-diketone compound solution to 8.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: March 15, 2016
    Assignee: Tanaka Kikinzoku Kogyo K.K.
    Inventors: Ryosuke Harada, Toshiyuki Shigetomi, Satoshi Miyazaki, Masayuki Saito
  • Patent number: 9284250
    Abstract: The present invention concerns a pharmaceutical compound having the Formula (1): or a pharmaceutically acceptable salt thereof, for use in the prevention or treatment of a cognitive, neurodegenerative or neuronal disorder or disease such as the Alzheimer Disease, a pharmaceutical composition and a method of preparing a pharmaceutical composition.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: March 15, 2016
    Assignee: CESA ALLIANCE S.A.
    Inventor: Reiner Van Tilborg
  • Patent number: 9284251
    Abstract: The invention relates to the field of medicine, and specifically to preparations for treating skin lesions, in particular viral, benign, precancerous and cancerous, non-metastasizing, dysplastic and inflammatory lesions of the visible mucous membranes, and also viral and fungal skin and nail lesions, and for correcting wrinkles and senile pigment blemishes, said preparations comprising solutions of complex compounds of salts of zinc and alpha-chlorocarboxylic acids of general formula [Zn(RCH2?xClxCOOH)n(H2O)4?n]+2.2[RCH2?xClxCOO]?, where R=alkyl, H or Cl, x=1-2 and n=0-4, in a corresponding alpha-chlorocarboxylic acid, wherein the content of zinc in the solution is 0.25-10.0% and the content of acid is 10-90%. The preparation may additionally contain an additive perfume, for example an ethyl ester of the corresponding alpha-chlorocarboxylic acid. The treatment method consists in that 2-5 doses of the preparation, which has been precooled to 10-15° C.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: March 15, 2016
    Assignee: Obschestvo S Ogranitchennoi Otvetstvennostju “OXYGON”
    Inventors: Shalva Iosifovitch Mardi, Lev Aleksandrovich Ustynyuk
  • Patent number: 9284252
    Abstract: The present invention relates to methods of treating benign hyperproliferative diseases of the epidermis by administering a composition comprising at least one jasmonate ester derivative. In particular, the present invention provides jasmonate ester derivatives as potent compounds useful for the treatment of disorders such as actinic keratoses with reduced side effects.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: March 15, 2016
    Assignee: SEPAL PHARMA LTD.
    Inventors: Max Herzberg, Frederic Revah
  • Patent number: 9284253
    Abstract: A process for preparing polyol esters by reacting polyols with linear or branched aliphatic monocarboxylic acids having 3 to 20 carbon atoms, is characterized in that a mixture of the starting compounds is allowed to react in the presence of a Lewis acid containing at least one element of groups 4 to 14 of the periodic table of the elements as a catalyst and in the presence of an adsorbent with removal of the water formed, and then the crude ester obtained is aftertreated by adding a further adsorbent which is an acidic activated carbon having a pH of 1 to 6.5.
    Type: Grant
    Filed: August 10, 2013
    Date of Patent: March 15, 2016
    Assignee: OXEA GMBH
    Inventors: Guido D. Frey, Tonia Weber, Jörg Arnold, Thorsten Kreickmann, Heinz Strutz
  • Patent number: 9284254
    Abstract: In an embodiment, a process for preparing an alkyl aryl carbonate and a diaryl carbonate, comprising: reacting a dialkyl carbonate and an aromatic hydroxy compound in a production column to form the alkyl aryl carbonate and the diaryl carbonate; directing a bottom stream of the production column to a reboiler, wherein the bottom stream comprises the alkyl aryl carbonate and the diaryl carbonate; heating the bottom stream in the reboiler with heat from an overhead stream of the production column to result in a heated bottom stream; directing a first portion of the heated bottom stream back into the production column, wherein the first portion comprises an aromatic hydroxy compound; and collecting the diaryl carbonate and the alkyl aryl carbonate from a second portion of the heated bottom stream.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: March 15, 2016
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Sergio Ferrer Nadal, Ignacio Vic Fernandez, Jose Antonio Caballero, Juan Javaloyes Anton
  • Patent number: 9284255
    Abstract: The invention relates to an adiabatic process for producing nitrobenzene by nitrating benzene with sulphuric acid mixtures and nitric acid mixtures using a stoichiometric excess of benzene and reusing non-reacted benzene, the content of the aliphatic organic compounds in the feed benzene being limited, by the targeted evacuation of aliphatic organic compounds to at least one step in the process, to a content of less than 1.5 mass-%, in relation to the total amount of feed benzene.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: March 15, 2016
    Assignee: Bayer MaterialScience AG
    Inventors: Thomas Knauf, Alexandre Racoes, Wolfgang Dohmen, Antoni Mairata
  • Patent number: 9284256
    Abstract: The present invention provides a continuous process for the production of nitrobenzene by nitration of benzene with mixtures of sulfuric and nitric acid using a stoichiometric excess of benzene, in which the content of aliphatic organic compounds in the feed benzene during the start-up period of the production plant is always maintained at less than 1.5 wt. %, based on the total mass of the feed benzene. This is achieved either by mixing the feed benzene comprising recycled unreacted benzene (recycled benzene) and benzene newly supplied to the reaction (fresh benzene) in appropriate quantitative ratios during the start-up period, depending on the purity of the two streams, or by completely omitting the recycling of unreacted benzene during the start-up period, i.e. the feed benzene consists only of benzene newly supplied to the reaction.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: March 15, 2016
    Assignee: Bayer MaterialScience AG
    Inventors: Thomas Knauf, Michael Merkel
  • Patent number: 9284257
    Abstract: Proposed is a separation method in a toluene to dinitrotoluene process, wherein said method with a first process step comprising feeding a toluene comprising first stream (1) and a nitric acid comprising second stream (2) into a first reactor (R1), reacting of the toluene comprising first stream (1) and the nitric acid comprising second stream (2) within the first reactor (R1) to a first reaction mixture (3), said first reaction mixture (3) comprising a first liquid/liquid mixed phase of an acid phase and an organic phase comprising mononitrotoluene, feeding the first reaction mixture (3) into a first separation device (S1), separating the first reaction mixture (3) within the first separation device (S1) into a first forward stream (4) having a flow direction to a second process step and a first backward stream (5) having a flow direction back to the first reactor (R1), said method having a second process step comprising feeding the first forward stream (4) into a second reactor (R2), feeding a nitric acid c
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: March 15, 2016
    Assignees: BASF SE, Shanghai BASF Polyurethane Company Limited
    Inventors: Yuanshen Dai, Da Peng Li, Pei Shi Jia, Zhan Cai, Samuel Neto
  • Patent number: 9284258
    Abstract: Disclosed is a novel process for the reduction of nitro groups to amino derivatives, based on the use of trichlorosilane and an organic base, which is efficient from the chemical standpoint and of wide general applicability.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: March 15, 2016
    Assignee: DEXLECHEM GMBH
    Inventors: Maurizio Benaglia, Martina Bonsignore
  • Patent number: 9284259
    Abstract: Pt0-nanoparticles in the size range of 0 to 10 nm were prepared in-situ by impregnation of H2PtCl6.6H2O into the nanopores of modified montmorillonite followed by reduction with different reducing agents like ethylene glycol, sodium citrate, hydrogen, hydrazine and sodium borohydrate. The montmorillonite was modified by activation with mineral acids under controlled condition for generating desired nanopores. XRD pattern of Pt0-nanoparticles revealed the formation of face centered cubic (fcc) lattice. These supported Pt0-nanoparticles show efficient catalytic activity for the selective reduction of chloronitrobenzenes. As a typical example, at a H2 pressure of 10 bars, temperature 45° C. for a period of 15 min, the Pt0-nanoparticles (prepared by reduction with hydrazine) exhibit conversion of o-chloronitrobenzene up to 100% and selectivity >99% to o-chloroanilines with very negligible amount of C—Cl bond cleavage.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: March 15, 2016
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Dipak Kumar Dutta, Dipanka Dutta
  • Patent number: 9284260
    Abstract: A method for producing a racemate of a compound represented by Formula (1), including bringing a transition metal catalyst into contact with an optically active form of the compound represented by Formula (1): [in Formula (1), a ring X1 represents an aromatic ring; R1 represents a C1-6 alkyl group, a C3-8 cycloalkyl group, or a C1-6 halo-alkyl group; R2 is a group different from R1 and represents a C1-6 alkyl group, a C3-8 cycloalkyl group, or a C1-6 halo-alkyl group, or R2 and the ring X1 are bonded to each other to form a ring; a hydrogen atom(s) of the ring X1 is optionally replaced with a C1-6 alkyl group, a C1-6 halo-alkyl group, a cyano group, a nitro group, a C1-6 alkoxy group, or a halogen atom; and * represents an asymmetric carbon atom].
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: March 15, 2016
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Tomoaki Takahashi, Taro Hirose
  • Patent number: 9284261
    Abstract: Fragrances that provide a scent of freshness tend to be volatile and are therefore not very economical when used in typical applications such as washing or cleaning processes, so they have to be used in relatively large quantities to be able to produce adequate effects. The disclosed photolabile pro-fragrances provide a much longer-lasting sense of fragrance, in particular with a scent of freshness, when used in typical applications, thus allowing said fragrances to be used economically.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: March 15, 2016
    Assignee: Henkel AG & Co. KGaA
    Inventors: Thomas Gerke, Christian Kropf, Ursula Huchel, Axel Griesbeck, Agnieszka Landes
  • Patent number: 9284262
    Abstract: The present invention relates to a method for preparing esteramide compounds. More particularly, the invention relates to a method for preparing esteramide compounds by reaction between a diester and an amine, in the presence of a basic compound, wherein the amine is solubilized in an organic solvent or in the diester, when the amine is solubilized in an organic solvent, the diester is added onto the reaction mixture comprising the amine and the basic compound, when the amine is solubilized in the diester, the basic compound is added onto the reaction mixture comprising the amine and the diester (II), the reaction is conducted at a temperature greater than or equal to 30° C., the amine is present in molar excess ranging from 0.01 to 50% relatively to the diester.
    Type: Grant
    Filed: June 9, 2011
    Date of Patent: March 15, 2016
    Assignee: RHODIA OPERATIONS
    Inventors: Thierry Vidal, Rabih Rached, Massimo Guglieri
  • Patent number: 9284263
    Abstract: The present invention is directed towards an improved, five step method for the preparation of the anti-epileptic drug (R)-Lacosamide, as illustrated in FIG. 2. The active form of the drug is (R)-enantiomer and the present method gives high yields of (R)-enantiomer of lacosamide. The method does not involve use of any unnatural amino acids as starting material or use of protection/deprotection strategies, strong acids or hydrogenation. Instead, the method uses a cheap and easily available racemic butadiene monoepoxide as the starting material.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: March 15, 2016
    Inventors: Satyendra Kumar Pandey, Yuvraj Garg
  • Patent number: 9284264
    Abstract: There is provided a mixture having a freezing point of up to 100° C. formed by a process comprising the step of contacting: (A) from 1 to 2 equivalents of a compound of formula (I) AlX3 (I) wherein each X independently represents Cl, Br or F; with (B) 1 equivalent of a compound of formula (II) R1—C(O)—N(R2)(R3) (II) wherein R1 to R3 have meanings given in the description. There is also provided further mixtures containing additional components, as well as methods of using the mixtures in various applications, such as for the electroreduction of the mixtures to produce aluminum metal.
    Type: Grant
    Filed: November 25, 2010
    Date of Patent: March 15, 2016
    Assignee: UNIVERSITY OF LEICESTER
    Inventors: Andrew Peter Abbott, Hadi Mohammad Ali Abood
  • Patent number: 9284265
    Abstract: The invention pertains to a highly efficient process for preparing a very pure organic acid salt of a cationic surfactant derived from the condensation of a fatty acid with an esterified dibasic amino acid. The process involves the following steps: (a) providing a reaction mixture comprising a mineral acid salt of the cationic surfactant and an alkali and/or alkaline earth metal salt of the organic acid; (b) allowing the reaction between the mineral acid salt of the cationic surfactant and the alkali and/or alkaline earth metal salt of the salt to proceed until substantially all of the mineral acid salt of the cationic surfactant has been converted to the organic acid salt of the cationic surfactant; and (c) recovering the organic acid salt of the cationic surfactant from the reaction mixture.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: March 15, 2016
    Inventor: Vishwas Sadhu Ghare
  • Patent number: 9284266
    Abstract: Disclosed is a method of the synthesis of ramalin. It comprises reacting a glutamic acid derivative, which is prepared using alkylchloroformate, with a hydrazine salt compound, which is prepared from hydroxy aniline, whether protected or not. The synthesis method allows ramalin, excellent in antioxidant and anti-inflammatory activity, to be simply synthesized at stable yield even without use of a highly toxic solvent such as DMF. In addition, the method is cost competitive, and provides ramalin at high efficiency, thus enabling the mass production of ramalin.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: March 15, 2016
    Assignee: KOREA INSTITUTE OF OCEAN SCIENCE AND TECHNOLOGY
    Inventors: Joung Han Yim, Il Chan Kim, Dockyu Kim, Se Jong Han, Hyoung Seok Lee, Hari Datta Bhattarai, Tai Kyoung Kim, Keun Sik Kim
  • Patent number: 9284267
    Abstract: Urethanes are prepared by oxidative carbonylation of at least one amino compound in the presence of carbon monoxide, oxygen and organic, at least one hydroxyl-group-carrying compound. The carbonylation is carried out in the absence of halogen-containing promoters. The carbonylation is also carried out in the presence of a metal complex catalyst which contains neutral bidentate N-chelate ligands of the (N˜N) type, two monoanionic N,O-chelate ligands of the general type (N˜O)? or tetradentate dianionic chelate ligands (O˜N˜N˜O)2?.
    Type: Grant
    Filed: January 28, 2009
    Date of Patent: March 15, 2016
    Assignee: Bayer MaterialScience AG
    Inventors: Andreas Jacob, Stefan Wershofen, Stephan Klein, Jörg Sundermeyer, Fuming Mei
  • Patent number: 9284268
    Abstract: The invention provides a method for producing fluorotrifluoromethylsulfonyl imide (FTFSI) by reacting non-fluorohalogenated trihalomethylsulfonyl imide (XTXSI) with hydrogen fluoride, where each X is independently a nonfluoro-halide, such as Cl, Br, or I.
    Type: Grant
    Filed: November 4, 2013
    Date of Patent: March 15, 2016
    Assignee: CoorsTek Fluorochemicals, Inc.
    Inventors: Joseph Carl Poshusta, Jerry Lynn Martin, Rajendra P. Singh
  • Patent number: 9284269
    Abstract: The present invention relates to solid forms of herbicide safeners, to processes for their preparation, compositions comprising the solid forms and methods of their use as safeners.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: March 15, 2016
    Assignee: Syngenta Limted
    Inventors: Ian Kevin Jones, Neil George, John Hone
  • Patent number: 9284270
    Abstract: The present application provides methods and catalysts for activation of carboxylic acids for organic reactions.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: March 15, 2016
    Assignees: The Governers of the University of Alberta, Greencentre Canada
    Inventors: Dennis Hall, Nicolas Gernigon, Raed M. Al-Zoubi, Paul D. Thornton
  • Patent number: 9284271
    Abstract: This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterized by cytotoxic ?-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds. The compounds have the formula (A1), wherein R1, R2, R4, R5, R6, E, n, Y1, Y2, Y3, Y4, Y5, B, R8, and m are as defined in the claims.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: March 15, 2016
    Assignees: Katholieke Universiteit Leuven, K.U. Leuven R&D, reMYND
    Inventors: Gerard Griffioen, Tom Van Dooren, Verónica Rojas De La Parra, Arnaud Marchand, Sara Alassia, Amuri Kilonda, Patrick Chaltin
  • Patent number: 9284272
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for treating cancer, inflammation, or autoimmune disease in a subject, or for inhibiting histone methyltransferase G9a.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: March 15, 2016
    Assignee: AbbVie Inc.
    Inventors: Marina A. Pliushchev, Gary G. Chiang, William N. Pappano, Michael R. Michaelides, Ramzi F. Sweis
  • Patent number: 9284273
    Abstract: A compound of the following compound (B): wherein tBu represents a tert-butyl group. A compound of the following compound (C): wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: March 15, 2016
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao Abe, Masayuki Okue, Yoshiaki Sakamaki
  • Patent number: 9284274
    Abstract: The present invention relates to novel jasmonate derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for prevention and treatment of cancers.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 15, 2016
    Assignee: RAMOT at Tel-Aviv University Ltd.
    Inventors: Yoel Kashman, Eliezer Flescher, Max Herzberg
  • Patent number: 9284275
    Abstract: A synergistically effective combination of an anti-cancer agent and a therapeutic compound, such as an mTOR-Rictor complex inhibitor, a Serine 473 phosphorylation inhibitor, an AKT2 inhibitor, or a combination thereof, for use in the treatment of cancer, and methods and uses thereof. Also included are methods and uses of a thiosemicarbazone for treating a cancer in a mammal in need thereof characterized by over-expression of RAS, by an EGFR mutation, and/or by over-expression of AKT2.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: March 15, 2016
    Assignee: CRITICAL OUTCOME TECHNOLOGIES INC.
    Inventor: Wayne R. Danter
  • Patent number: 9284276
    Abstract: The subject invention provides a pharmaceutical composition containing laquinimod or a pharmaceutically acceptable salt thereof, and a compound of N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide or a salt thereof.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: March 15, 2016
    Assignee: TEVA PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Vladimir Ioffe, Konstantin Ulanenko, Avital Laxer, Muhammad Safadi, Danit Licht, Ioana Lovinger, Ulf Tomas Fristedt
  • Patent number: 9284277
    Abstract: The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are benzazepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: March 15, 2016
    Assignee: ABT Holding Company
    Inventors: Mike Robarge, John Harrington, David Gerrish, John Mecom
  • Patent number: 9284278
    Abstract: Metal complexes of the formula I or I? [LDH]nM[L]m (I) [LTH](M[L]p)2 (I1) wherein n is an integer 1 or 2, m and p each is an integer 1 or 2, the sum (n+m) being 2 or 3, M is a metal with an atomic weight of greater than 40 such as Iridium, L is a ligand as described in claim 1, and LDH is a bidentate ligand of the formula I1 and LTH is a dimer of LDH, binding to 2 metal atoms M, of the formula II? wherein W is selected from O, S, NR4, CR5R6, X is N or CR7, Y is selected from O, S, NR8; and further residues are as defined in claim 1, show good light emitting efficiency in electroluminescent applications.
    Type: Grant
    Filed: February 4, 2008
    Date of Patent: March 15, 2016
    Assignee: BASF SE
    Inventors: Annemarie Wolleb, Heinz Wolleb
  • Patent number: 9284279
    Abstract: Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: March 15, 2016
    Assignee: Afferent Pharmaceuticals, Inc.
    Inventors: Anthony P. Ford, Bruce G. McCarthy
  • Patent number: 9284280
    Abstract: A method is provided in which Form-I crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide is administered as an active ingredient to a subject for the purpose of treating or preventing certain diseases, disorders, and symptoms, or for promoting angiogenesis or gene therapy. The Form-I crystal exhibits diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2? when the spectrum is obtained by using Cu K? radiation: 9.4 degrees, 9.8 degrees, 17.2 degrees, and 19.4 degrees.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: March 15, 2016
    Assignee: NIPPON SHINYAKU CO., LTD.
    Inventor: Hideyuki Itou
  • Patent number: 9284281
    Abstract: Disclosed are naphtho[2,3-f]quinoxaline compounds and pharmaceutical composition thereof. The compounds of the invention have been demonstrated as having analgesic effects and therefore may be applicable for use as a novel agent in relieving acute or chronic pain.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: March 15, 2016
    Assignee: NATIONAL CENTRAL UNIVERSITY
    Inventors: Wei-Hsin Sun, Shir-Ly Huang, Hsu-Shan Hunag
  • Patent number: 9284282
    Abstract: A TAF compound that can have substitutions on either of the two benzene rings and/or the C-5 position of the triazole to alter the properties of the TAF compound can be wherein X can be H, an aromatic group, a hetero aromatic group, an alkyl or any substituted alkyl group, ketone, aldyhyde, carboxylic acid derivatives; Y1, Y2, Y3, Y4, and Y5 can be one or more of H, aromatic groups, hetero aromatic groups, alkyl or any substituted alkyl groups, ketone, aldyhyde, or carboxylic acid derivatives; and Z1, Z2, Z3, Z4 and Z5 can be one or more of H aromatic groups, hetero aromatic groups, alkyl or any substituted alkyl groups, ketone, aldyhyde, or carboxylic acid derivatives. Included is a preparation of the TAF compound and use as a photoactive and/or catalyst.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: March 15, 2016
    Assignee: West Virginia University
    Inventor: Xiaodong Shi