Patents Issued in March 15, 2016
-
Patent number: 9284233Abstract: A method for manufacturing a pelletized fertilizer includes the following steps. A water-soluble manure and a colloidal solution are mixed, to form an aqueous solution of a fertilizer, wherein the water-soluble manure is selected from the group consisting of monopotassium phosphate, epsomite, manganous sulfite, boric acid, borax, copper sulfate pentahydrate, white vitriol, ammonium molybdate, urea, ferric ethylenediaminetetraacetic acid and potassium nitrate, the colloidal solution is selected from the group consisting of agar, xanthan gum, shellac, guar gum, natto gum, pectin, synthetic hydrogel and PLGA, and the weight percentage of the colloidal solution in the aqueous solution of the fertilizer is between 1.5 and 15%. The aqueous solution of the fertilizer is added into a water within a temperature range between 0 and 4° C., whereby the aqueous solution of the fertilizer is solidified to the pelletized fertilizer.Type: GrantFiled: March 4, 2013Date of Patent: March 15, 2016Assignee: CHUNGHWA PICTURE TUBES, LTD.Inventors: Chou-Chiang Kuo, Min-Lun Wu, Che-Wei Chang
-
Patent number: 9284234Abstract: Provided is a gasoline production device capable of effectively using heat of reaction generated in the synthesis of gasoline and also capable of readily cooling heat generated by synthesizing gasoline. A device 30 for producing gasoline from methanol includes a plurality of reaction tubes 34 configured to synthesize gasoline from methanol and a duct 36 configured to allow air to flow outside the reaction tubes, and heat exchange is carried out between synthesis heat generated within the reaction tubes 34 and the air which flows through the duct 36.Type: GrantFiled: December 13, 2012Date of Patent: March 15, 2016Assignee: MITSUBISHI HEAVY INDUSTRIES, LTD.Inventor: Masaki Iijima
-
Patent number: 9284235Abstract: The present invention provides a process for methanol coupled catalytic cracking reaction of naphtha using a modified ZSM-5 molecular sieve catalyst, comprising performing a co-feeding reaction of methanol and naphtha on the modified ZSM-5 molecular sieve catalyst to produce low carbon olefins and/or aromatic hydrocarbons. In the process, the modified ZSM-5 molecular sieve catalyst comprises, in term of weight percent, 25-80 wt % of a ZSM-5 molecular sieve, 15-70 wt % of a binder, and 2.2-6.0 wt % of lanthanum and 1.0-2.8 wt % of phosphorus loaded on the ZSM-5 molecular sieve. The naphtha comprises 63.8-89.5 wt % of saturated chain alkanes and 5.6-29.8 wt % of cyclic alkanes. The naphtha and methanol concurrently pass through the catalyst bed, which are reacted during contacting with the catalyst under a reaction condition of a reaction temperature of 550-670° C., a mass ratio of methanol to naphtha of 0.05-0.8, and a total mass space velocity of naphtha and methanol of 1.0-5 h?1.Type: GrantFiled: June 24, 2011Date of Patent: March 15, 2016Assignee: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Zhongmin Liu, Yingxu Wei, Yue Qi, Mao Ye, Mingzhi Li, Bing Li, Xiangao Wang, Changqing He, Xinde Sun
-
Patent number: 9284236Abstract: A process is described for treating a natural gas stream containing methane and one or more higher hydrocarbons including the steps of: (i) mixing at least a portion of the natural gas stream with steam, (ii) passing the mixture adiabatically over a supported precious metal reforming catalyst to generate a reformed gas mixture comprising methane, steam, carbon dioxide, carbon monoxide and hydrogen, (iii) cooling the reformed gas mixture to below the dew point to condense water and removing the condensate to provide a de-watered reformed gas mixture, and (iv) passing the de-watered reformed gas mixture through an acid gas recovery unit to remove carbon dioxide and at least a portion of the hydrogen and carbon monoxide, thereby generating a methane stream. The methane stream may be used to adjust the composition of a natural gas stream, including a vaporized LNG stream, to meet pipeline specifications.Type: GrantFiled: December 16, 2010Date of Patent: March 15, 2016Assignee: Johnson Matthey PLCInventor: Stephen John Catchpole
-
Patent number: 9284237Abstract: Methods and apparatuses for processing hydrocarbons are provided. In one embodiment, a method for processing hydrocarbons includes providing a stream of olefins including normal olefins and non-normal olefins. The method includes separating the normal olefins from the non-normal olefins to form a stream of normal olefins. Further, the method polymerizes the stream of normal olefins to form a stream of polymerized normal olefins. The method also includes saturating the stream of polymerized normal olefins to form a stream of normal paraffins.Type: GrantFiled: December 13, 2013Date of Patent: March 15, 2016Assignee: UOP LLCInventors: Chad R. Huovie, Charles P. Luebke
-
Patent number: 9284238Abstract: The present invention relates to a method for purification of a hydrocarbon stream containing linear alpha olefins, isomers thereof and at least one organic amine, the linear alpha olefins, isomers and the amine having boiling points under atmospheric pressure which differ by at most 5° C., comprising the step of removing a major amount of the organic amine from the hydrocarbon stream by distillation, wherein the distillation is carried out to that, together with the amine, between 5% and 95 wt % of the isomers, based on the total amount of the isomers in the hydrocarbon stream, are removed from the hydrocarbon stream in an amine/isomer-rich fraction.Type: GrantFiled: September 27, 2011Date of Patent: March 15, 2016Assignees: SAUDI BASIC INDUSTRIES CORPORATION, LINDE AGInventors: Wolfgang Müller, Marco Harff, Anton Wellenhofer, Anina Wöhl, Heinz Bölt, Andreas Meiswinkel
-
Patent number: 9284239Abstract: Processes for the production of chlorinated alkanes are provided. The present processes comprise catalyzing the chlorination of a feedstream comprising one or more alkanes and/or alkenes with a catalyst system comprising one or more inorganic iodine salts and/or lower than conventional levels of elemental iodine and at least one Lewis acid. The processes are conducted in a nonaqueous media, and so, the one or more inorganic iodine salts are recoverable and/or reusable, in whole or in part.Type: GrantFiled: November 30, 2012Date of Patent: March 15, 2016Assignee: BLUE CUBE IP LLCInventors: Matthew L. Grandbois, Xiaoyun Chen, William J. Kruper, Jr.
-
Patent number: 9284240Abstract: The present invention provides a process of catalytic fluorination in gas phase of product 1,1,1,2,3-pentachloropropane or/and 1,1,2,2,3-pentachloropropane into product 2-chloro-3,3,3-trifluoropropene in presence of a catalyst and oxygen.Type: GrantFiled: October 22, 2010Date of Patent: March 15, 2016Assignee: Arkema FranceInventors: Philippe Bonnet, Anne Pigamo, Laurent Wendlinger, Nicolas Doucet
-
Patent number: 9284241Abstract: A method for removing a contaminant from a hydrochlorofluoroolefin (such as trans-1,1,1-trifluoro-3-chloro-2-propene (1233zd(E))) includes extracting a chlorofluorocarbon (such as trichlorofluoromethane (R11)) from a mixture comprising the hydrochlorofluoroolefin and the chlorofluorocarbon using extractive distillation in the presence of an extractive solvent comprising a chlorinated compound to form a purified hydrochlorofluoroolefin. This separation method provides for removal of a contaminant, such as R11, from a hydrochlorofluoroolefin, such as 1232zd(E), which are not separable by conventional distillation methods. The method may employ a process utilizing two distillation columns, for example, a first extractive distillation column and a second solvent recovery column, which allows for recycle of the extractive solvent to the first extractive distillation column.Type: GrantFiled: February 22, 2013Date of Patent: March 15, 2016Assignee: Arkema Inc.Inventor: John A. Wismer
-
Methods and systems for processing lignin during hydrothermal digestion of cellulosic biomass solids
Patent number: 9284242Abstract: Digestion of cellulosic biomass solids may be complicated by release of lignin therefrom. Methods for digesting cellulosic biomass solids may comprise: providing cellulosic biomass solids in a digestion solvent; at least partially converting the cellulosic biomass solids into a phenolics liquid phase comprising lignin, an aqueous phase comprising an alcoholic component derived from the cellulosic biomass solids, and an optional light organics phase; combining at least the phenolics liquid phase and the aqueous phase with one another, thereby forming a combined phase; and separating at least a portion of the alcoholic component from at least a portion of the combined phase.Type: GrantFiled: October 30, 2013Date of Patent: March 15, 2016Assignee: Shell Oil CompanyInventors: Joseph Broun Powell, Kimberly Ann Johnson, Glenn Charles Komplin, Edward James Denton -
Patent number: 9284243Abstract: Subject of the invention is a process for the production of methylbutynol, wherein the process comprises at least one pervaporation step. In a preferred embodiment, the process comprises the steps of (a) providing a feed composition comprising methylbutynol and water, (b) subjecting the feed composition to distillation in a distillation device, (c) removing a sidestream from the distillation device, the sidestream having a higher water content than the feed composition, and (d) subjecting said sidestream to pervaporation, thereby reducing the water content. The invention also relates to uses and devices relating to the inventive process.Type: GrantFiled: July 11, 2013Date of Patent: March 15, 2016Assignee: LONZA LTDInventors: Stefan Ottiger, Thomas Scholl, Stefan Stoffel, Klaus Kalbermatter, Andreas Klein, Kishore Nedungadi
-
Patent number: 9284244Abstract: A method and system for precipitation and separation of carboxylic acid salts from a hydrate inhibitor solution is disclosed. The method comprises lowering the solubility of the carboxylic acid salts to force precipitation of carboxylic acid salts and separation of the precipitated carboxylic acid salts from the hydrate inhibitor solution.Type: GrantFiled: May 6, 2013Date of Patent: March 15, 2016Assignee: FJORDS PROCESSING ASInventor: Salim Deshmukh
-
Patent number: 9284245Abstract: A monomer for a hardmask composition represented by the following Chemical Formula 1,Type: GrantFiled: November 19, 2013Date of Patent: March 15, 2016Assignee: CHEIL INDUSTRIES, INC.Inventors: Sung-Jae Lee, Hwan-Sung Cheon, Youn-Jin Cho, Chul-Ho Lee, Chung-Heon Lee
-
Patent number: 9284246Abstract: A method for producing an optically active 2,3-dihydrofarnesal of formula (1) is disclosed.Type: GrantFiled: September 6, 2013Date of Patent: March 15, 2016Assignee: TAKASAGO INTERNATIONAL CORPORATIONInventors: Hideo Ujihara, Mitsuhiko Fujiwhara
-
Patent number: 9284247Abstract: The invention relates to a method for producing at least one alkoxy-hydroxybenzaldehyde (AHBA) from at least one hydroxyphenol (HP), said method being characterized in that it comprises the formation of at least one alkoxyphenol (AP) and alkyl-alkoxyphenol (AAP) and the separation (S) of AP from AAP, said separation (S) being carried out prior to obtaining AHBA.Type: GrantFiled: July 12, 2013Date of Patent: March 15, 2016Assignee: Rhodia OperationsInventors: Laurent Garel, Hubert Gayet
-
Patent number: 9284248Abstract: A production process of an ?-fluoroaldehyde according to the present invention includes reaction of an ?-fluoroester with hydrogen gas (H2) in the presence of a ruthenium complex. It is possible in the present invention to allow relatively easy industrial production of the ?-fluoroaldehyde and to directly obtain, as stable synthetic equivalents of the ?-fluoroaldehyde, not only a hydrate (as obtained by conventional techniques) but also a hemiacetal that is easy to purify and is of high value in synthetic applications. The present invention provides solutions to all problems in the conventional techniques and establishes the significantly useful process for production of the ?-fluoroaldehyde.Type: GrantFiled: March 25, 2015Date of Patent: March 15, 2016Assignee: Central Glass Company, LimitedInventors: Akihiro Ishii, Takashi Ootsuka, Mari Imamura, Takayuki Nishimiya, Kazuto Kimura
-
Patent number: 9284249Abstract: The present invention provides a method of extracting an asymmetric ?-diketone compound from a ?-diketone compound containing at least one symmetric ?-diketone compound mixed in the asymmetric ?-diketone compound, and the method includes the step (A) of adjusting a pH of a mixed solution of the ?-diketone compound and water at 11.5 or more and dissolving the ?-diketone compound into water to form a ?-diketone compound solution and the step (B) of subsequently adjusting the pH of the ?-diketone compound solution at 9.5 or less and recovering the asymmetric ?-diketone compound of Chemical Formula 1 separated from the ?-diketone compound solution. The present invention further includes at least either (a) a step of setting the upper limit of the pH of the mixed solution to 12.5 to form a ?-diketone compound solution in the step (A) and bringing the ?-diketone compound solution into contact with a hydrophobic solvent or (b) a step of setting the lower limit of the pH of the ?-diketone compound solution to 8.Type: GrantFiled: October 17, 2013Date of Patent: March 15, 2016Assignee: Tanaka Kikinzoku Kogyo K.K.Inventors: Ryosuke Harada, Toshiyuki Shigetomi, Satoshi Miyazaki, Masayuki Saito
-
Patent number: 9284250Abstract: The present invention concerns a pharmaceutical compound having the Formula (1): or a pharmaceutically acceptable salt thereof, for use in the prevention or treatment of a cognitive, neurodegenerative or neuronal disorder or disease such as the Alzheimer Disease, a pharmaceutical composition and a method of preparing a pharmaceutical composition.Type: GrantFiled: December 17, 2013Date of Patent: March 15, 2016Assignee: CESA ALLIANCE S.A.Inventor: Reiner Van Tilborg
-
Patent number: 9284251Abstract: The invention relates to the field of medicine, and specifically to preparations for treating skin lesions, in particular viral, benign, precancerous and cancerous, non-metastasizing, dysplastic and inflammatory lesions of the visible mucous membranes, and also viral and fungal skin and nail lesions, and for correcting wrinkles and senile pigment blemishes, said preparations comprising solutions of complex compounds of salts of zinc and alpha-chlorocarboxylic acids of general formula [Zn(RCH2?xClxCOOH)n(H2O)4?n]+2.2[RCH2?xClxCOO]?, where R=alkyl, H or Cl, x=1-2 and n=0-4, in a corresponding alpha-chlorocarboxylic acid, wherein the content of zinc in the solution is 0.25-10.0% and the content of acid is 10-90%. The preparation may additionally contain an additive perfume, for example an ethyl ester of the corresponding alpha-chlorocarboxylic acid. The treatment method consists in that 2-5 doses of the preparation, which has been precooled to 10-15° C.Type: GrantFiled: November 14, 2011Date of Patent: March 15, 2016Assignee: Obschestvo S Ogranitchennoi Otvetstvennostju “OXYGON”Inventors: Shalva Iosifovitch Mardi, Lev Aleksandrovich Ustynyuk
-
Patent number: 9284252Abstract: The present invention relates to methods of treating benign hyperproliferative diseases of the epidermis by administering a composition comprising at least one jasmonate ester derivative. In particular, the present invention provides jasmonate ester derivatives as potent compounds useful for the treatment of disorders such as actinic keratoses with reduced side effects.Type: GrantFiled: September 25, 2014Date of Patent: March 15, 2016Assignee: SEPAL PHARMA LTD.Inventors: Max Herzberg, Frederic Revah
-
Patent number: 9284253Abstract: A process for preparing polyol esters by reacting polyols with linear or branched aliphatic monocarboxylic acids having 3 to 20 carbon atoms, is characterized in that a mixture of the starting compounds is allowed to react in the presence of a Lewis acid containing at least one element of groups 4 to 14 of the periodic table of the elements as a catalyst and in the presence of an adsorbent with removal of the water formed, and then the crude ester obtained is aftertreated by adding a further adsorbent which is an acidic activated carbon having a pH of 1 to 6.5.Type: GrantFiled: August 10, 2013Date of Patent: March 15, 2016Assignee: OXEA GMBHInventors: Guido D. Frey, Tonia Weber, Jörg Arnold, Thorsten Kreickmann, Heinz Strutz
-
Patent number: 9284254Abstract: In an embodiment, a process for preparing an alkyl aryl carbonate and a diaryl carbonate, comprising: reacting a dialkyl carbonate and an aromatic hydroxy compound in a production column to form the alkyl aryl carbonate and the diaryl carbonate; directing a bottom stream of the production column to a reboiler, wherein the bottom stream comprises the alkyl aryl carbonate and the diaryl carbonate; heating the bottom stream in the reboiler with heat from an overhead stream of the production column to result in a heated bottom stream; directing a first portion of the heated bottom stream back into the production column, wherein the first portion comprises an aromatic hydroxy compound; and collecting the diaryl carbonate and the alkyl aryl carbonate from a second portion of the heated bottom stream.Type: GrantFiled: September 19, 2013Date of Patent: March 15, 2016Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Sergio Ferrer Nadal, Ignacio Vic Fernandez, Jose Antonio Caballero, Juan Javaloyes Anton
-
Patent number: 9284255Abstract: The invention relates to an adiabatic process for producing nitrobenzene by nitrating benzene with sulphuric acid mixtures and nitric acid mixtures using a stoichiometric excess of benzene and reusing non-reacted benzene, the content of the aliphatic organic compounds in the feed benzene being limited, by the targeted evacuation of aliphatic organic compounds to at least one step in the process, to a content of less than 1.5 mass-%, in relation to the total amount of feed benzene.Type: GrantFiled: July 23, 2013Date of Patent: March 15, 2016Assignee: Bayer MaterialScience AGInventors: Thomas Knauf, Alexandre Racoes, Wolfgang Dohmen, Antoni Mairata
-
Patent number: 9284256Abstract: The present invention provides a continuous process for the production of nitrobenzene by nitration of benzene with mixtures of sulfuric and nitric acid using a stoichiometric excess of benzene, in which the content of aliphatic organic compounds in the feed benzene during the start-up period of the production plant is always maintained at less than 1.5 wt. %, based on the total mass of the feed benzene. This is achieved either by mixing the feed benzene comprising recycled unreacted benzene (recycled benzene) and benzene newly supplied to the reaction (fresh benzene) in appropriate quantitative ratios during the start-up period, depending on the purity of the two streams, or by completely omitting the recycling of unreacted benzene during the start-up period, i.e. the feed benzene consists only of benzene newly supplied to the reaction.Type: GrantFiled: July 23, 2013Date of Patent: March 15, 2016Assignee: Bayer MaterialScience AGInventors: Thomas Knauf, Michael Merkel
-
Patent number: 9284257Abstract: Proposed is a separation method in a toluene to dinitrotoluene process, wherein said method with a first process step comprising feeding a toluene comprising first stream (1) and a nitric acid comprising second stream (2) into a first reactor (R1), reacting of the toluene comprising first stream (1) and the nitric acid comprising second stream (2) within the first reactor (R1) to a first reaction mixture (3), said first reaction mixture (3) comprising a first liquid/liquid mixed phase of an acid phase and an organic phase comprising mononitrotoluene, feeding the first reaction mixture (3) into a first separation device (S1), separating the first reaction mixture (3) within the first separation device (S1) into a first forward stream (4) having a flow direction to a second process step and a first backward stream (5) having a flow direction back to the first reactor (R1), said method having a second process step comprising feeding the first forward stream (4) into a second reactor (R2), feeding a nitric acid cType: GrantFiled: December 10, 2013Date of Patent: March 15, 2016Assignees: BASF SE, Shanghai BASF Polyurethane Company LimitedInventors: Yuanshen Dai, Da Peng Li, Pei Shi Jia, Zhan Cai, Samuel Neto
-
Patent number: 9284258Abstract: Disclosed is a novel process for the reduction of nitro groups to amino derivatives, based on the use of trichlorosilane and an organic base, which is efficient from the chemical standpoint and of wide general applicability.Type: GrantFiled: September 5, 2013Date of Patent: March 15, 2016Assignee: DEXLECHEM GMBHInventors: Maurizio Benaglia, Martina Bonsignore
-
Patent number: 9284259Abstract: Pt0-nanoparticles in the size range of 0 to 10 nm were prepared in-situ by impregnation of H2PtCl6.6H2O into the nanopores of modified montmorillonite followed by reduction with different reducing agents like ethylene glycol, sodium citrate, hydrogen, hydrazine and sodium borohydrate. The montmorillonite was modified by activation with mineral acids under controlled condition for generating desired nanopores. XRD pattern of Pt0-nanoparticles revealed the formation of face centered cubic (fcc) lattice. These supported Pt0-nanoparticles show efficient catalytic activity for the selective reduction of chloronitrobenzenes. As a typical example, at a H2 pressure of 10 bars, temperature 45° C. for a period of 15 min, the Pt0-nanoparticles (prepared by reduction with hydrazine) exhibit conversion of o-chloronitrobenzene up to 100% and selectivity >99% to o-chloroanilines with very negligible amount of C—Cl bond cleavage.Type: GrantFiled: November 21, 2014Date of Patent: March 15, 2016Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Dipak Kumar Dutta, Dipanka Dutta
-
Patent number: 9284260Abstract: A method for producing a racemate of a compound represented by Formula (1), including bringing a transition metal catalyst into contact with an optically active form of the compound represented by Formula (1): [in Formula (1), a ring X1 represents an aromatic ring; R1 represents a C1-6 alkyl group, a C3-8 cycloalkyl group, or a C1-6 halo-alkyl group; R2 is a group different from R1 and represents a C1-6 alkyl group, a C3-8 cycloalkyl group, or a C1-6 halo-alkyl group, or R2 and the ring X1 are bonded to each other to form a ring; a hydrogen atom(s) of the ring X1 is optionally replaced with a C1-6 alkyl group, a C1-6 halo-alkyl group, a cyano group, a nitro group, a C1-6 alkoxy group, or a halogen atom; and * represents an asymmetric carbon atom].Type: GrantFiled: October 28, 2013Date of Patent: March 15, 2016Assignee: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Tomoaki Takahashi, Taro Hirose
-
Patent number: 9284261Abstract: Fragrances that provide a scent of freshness tend to be volatile and are therefore not very economical when used in typical applications such as washing or cleaning processes, so they have to be used in relatively large quantities to be able to produce adequate effects. The disclosed photolabile pro-fragrances provide a much longer-lasting sense of fragrance, in particular with a scent of freshness, when used in typical applications, thus allowing said fragrances to be used economically.Type: GrantFiled: December 15, 2014Date of Patent: March 15, 2016Assignee: Henkel AG & Co. KGaAInventors: Thomas Gerke, Christian Kropf, Ursula Huchel, Axel Griesbeck, Agnieszka Landes
-
Patent number: 9284262Abstract: The present invention relates to a method for preparing esteramide compounds. More particularly, the invention relates to a method for preparing esteramide compounds by reaction between a diester and an amine, in the presence of a basic compound, wherein the amine is solubilized in an organic solvent or in the diester, when the amine is solubilized in an organic solvent, the diester is added onto the reaction mixture comprising the amine and the basic compound, when the amine is solubilized in the diester, the basic compound is added onto the reaction mixture comprising the amine and the diester (II), the reaction is conducted at a temperature greater than or equal to 30° C., the amine is present in molar excess ranging from 0.01 to 50% relatively to the diester.Type: GrantFiled: June 9, 2011Date of Patent: March 15, 2016Assignee: RHODIA OPERATIONSInventors: Thierry Vidal, Rabih Rached, Massimo Guglieri
-
Patent number: 9284263Abstract: The present invention is directed towards an improved, five step method for the preparation of the anti-epileptic drug (R)-Lacosamide, as illustrated in FIG. 2. The active form of the drug is (R)-enantiomer and the present method gives high yields of (R)-enantiomer of lacosamide. The method does not involve use of any unnatural amino acids as starting material or use of protection/deprotection strategies, strong acids or hydrogenation. Instead, the method uses a cheap and easily available racemic butadiene monoepoxide as the starting material.Type: GrantFiled: March 12, 2015Date of Patent: March 15, 2016Inventors: Satyendra Kumar Pandey, Yuvraj Garg
-
Patent number: 9284264Abstract: There is provided a mixture having a freezing point of up to 100° C. formed by a process comprising the step of contacting: (A) from 1 to 2 equivalents of a compound of formula (I) AlX3 (I) wherein each X independently represents Cl, Br or F; with (B) 1 equivalent of a compound of formula (II) R1—C(O)—N(R2)(R3) (II) wherein R1 to R3 have meanings given in the description. There is also provided further mixtures containing additional components, as well as methods of using the mixtures in various applications, such as for the electroreduction of the mixtures to produce aluminum metal.Type: GrantFiled: November 25, 2010Date of Patent: March 15, 2016Assignee: UNIVERSITY OF LEICESTERInventors: Andrew Peter Abbott, Hadi Mohammad Ali Abood
-
Patent number: 9284265Abstract: The invention pertains to a highly efficient process for preparing a very pure organic acid salt of a cationic surfactant derived from the condensation of a fatty acid with an esterified dibasic amino acid. The process involves the following steps: (a) providing a reaction mixture comprising a mineral acid salt of the cationic surfactant and an alkali and/or alkaline earth metal salt of the organic acid; (b) allowing the reaction between the mineral acid salt of the cationic surfactant and the alkali and/or alkaline earth metal salt of the salt to proceed until substantially all of the mineral acid salt of the cationic surfactant has been converted to the organic acid salt of the cationic surfactant; and (c) recovering the organic acid salt of the cationic surfactant from the reaction mixture.Type: GrantFiled: May 10, 2012Date of Patent: March 15, 2016Inventor: Vishwas Sadhu Ghare
-
Patent number: 9284266Abstract: Disclosed is a method of the synthesis of ramalin. It comprises reacting a glutamic acid derivative, which is prepared using alkylchloroformate, with a hydrazine salt compound, which is prepared from hydroxy aniline, whether protected or not. The synthesis method allows ramalin, excellent in antioxidant and anti-inflammatory activity, to be simply synthesized at stable yield even without use of a highly toxic solvent such as DMF. In addition, the method is cost competitive, and provides ramalin at high efficiency, thus enabling the mass production of ramalin.Type: GrantFiled: March 26, 2012Date of Patent: March 15, 2016Assignee: KOREA INSTITUTE OF OCEAN SCIENCE AND TECHNOLOGYInventors: Joung Han Yim, Il Chan Kim, Dockyu Kim, Se Jong Han, Hyoung Seok Lee, Hari Datta Bhattarai, Tai Kyoung Kim, Keun Sik Kim
-
Patent number: 9284267Abstract: Urethanes are prepared by oxidative carbonylation of at least one amino compound in the presence of carbon monoxide, oxygen and organic, at least one hydroxyl-group-carrying compound. The carbonylation is carried out in the absence of halogen-containing promoters. The carbonylation is also carried out in the presence of a metal complex catalyst which contains neutral bidentate N-chelate ligands of the (N˜N) type, two monoanionic N,O-chelate ligands of the general type (N˜O)? or tetradentate dianionic chelate ligands (O˜N˜N˜O)2?.Type: GrantFiled: January 28, 2009Date of Patent: March 15, 2016Assignee: Bayer MaterialScience AGInventors: Andreas Jacob, Stefan Wershofen, Stephan Klein, Jörg Sundermeyer, Fuming Mei
-
Patent number: 9284268Abstract: The invention provides a method for producing fluorotrifluoromethylsulfonyl imide (FTFSI) by reacting non-fluorohalogenated trihalomethylsulfonyl imide (XTXSI) with hydrogen fluoride, where each X is independently a nonfluoro-halide, such as Cl, Br, or I.Type: GrantFiled: November 4, 2013Date of Patent: March 15, 2016Assignee: CoorsTek Fluorochemicals, Inc.Inventors: Joseph Carl Poshusta, Jerry Lynn Martin, Rajendra P. Singh
-
Patent number: 9284269Abstract: The present invention relates to solid forms of herbicide safeners, to processes for their preparation, compositions comprising the solid forms and methods of their use as safeners.Type: GrantFiled: February 8, 2013Date of Patent: March 15, 2016Assignee: Syngenta LimtedInventors: Ian Kevin Jones, Neil George, John Hone
-
Patent number: 9284270Abstract: The present application provides methods and catalysts for activation of carboxylic acids for organic reactions.Type: GrantFiled: February 14, 2012Date of Patent: March 15, 2016Assignees: The Governers of the University of Alberta, Greencentre CanadaInventors: Dennis Hall, Nicolas Gernigon, Raed M. Al-Zoubi, Paul D. Thornton
-
Patent number: 9284271Abstract: This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterized by cytotoxic ?-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds. The compounds have the formula (A1), wherein R1, R2, R4, R5, R6, E, n, Y1, Y2, Y3, Y4, Y5, B, R8, and m are as defined in the claims.Type: GrantFiled: December 13, 2011Date of Patent: March 15, 2016Assignees: Katholieke Universiteit Leuven, K.U. Leuven R&D, reMYNDInventors: Gerard Griffioen, Tom Van Dooren, Verónica Rojas De La Parra, Arnaud Marchand, Sara Alassia, Amuri Kilonda, Patrick Chaltin
-
Patent number: 9284272Abstract: Described herein are compounds, pharmaceutical compositions and methods for treating cancer, inflammation, or autoimmune disease in a subject, or for inhibiting histone methyltransferase G9a.Type: GrantFiled: March 28, 2014Date of Patent: March 15, 2016Assignee: AbbVie Inc.Inventors: Marina A. Pliushchev, Gary G. Chiang, William N. Pappano, Michael R. Michaelides, Ramzi F. Sweis
-
Patent number: 9284273Abstract: A compound of the following compound (B): wherein tBu represents a tert-butyl group. A compound of the following compound (C): wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group.Type: GrantFiled: April 1, 2015Date of Patent: March 15, 2016Assignee: MEIJI SEIKA PHARMA CO., LTD.Inventors: Takao Abe, Masayuki Okue, Yoshiaki Sakamaki
-
Patent number: 9284274Abstract: The present invention relates to novel jasmonate derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for prevention and treatment of cancers.Type: GrantFiled: March 15, 2013Date of Patent: March 15, 2016Assignee: RAMOT at Tel-Aviv University Ltd.Inventors: Yoel Kashman, Eliezer Flescher, Max Herzberg
-
Patent number: 9284275Abstract: A synergistically effective combination of an anti-cancer agent and a therapeutic compound, such as an mTOR-Rictor complex inhibitor, a Serine 473 phosphorylation inhibitor, an AKT2 inhibitor, or a combination thereof, for use in the treatment of cancer, and methods and uses thereof. Also included are methods and uses of a thiosemicarbazone for treating a cancer in a mammal in need thereof characterized by over-expression of RAS, by an EGFR mutation, and/or by over-expression of AKT2.Type: GrantFiled: November 8, 2013Date of Patent: March 15, 2016Assignee: CRITICAL OUTCOME TECHNOLOGIES INC.Inventor: Wayne R. Danter
-
Patent number: 9284276Abstract: The subject invention provides a pharmaceutical composition containing laquinimod or a pharmaceutically acceptable salt thereof, and a compound of N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide or a salt thereof.Type: GrantFiled: February 15, 2013Date of Patent: March 15, 2016Assignee: TEVA PHARMACEUTICAL INDUSTRIES, LTD.Inventors: Vladimir Ioffe, Konstantin Ulanenko, Avital Laxer, Muhammad Safadi, Danit Licht, Ioana Lovinger, Ulf Tomas Fristedt
-
Patent number: 9284277Abstract: The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are benzazepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).Type: GrantFiled: December 23, 2013Date of Patent: March 15, 2016Assignee: ABT Holding CompanyInventors: Mike Robarge, John Harrington, David Gerrish, John Mecom
-
Patent number: 9284278Abstract: Metal complexes of the formula I or I? [LDH]nM[L]m (I) [LTH](M[L]p)2 (I1) wherein n is an integer 1 or 2, m and p each is an integer 1 or 2, the sum (n+m) being 2 or 3, M is a metal with an atomic weight of greater than 40 such as Iridium, L is a ligand as described in claim 1, and LDH is a bidentate ligand of the formula I1 and LTH is a dimer of LDH, binding to 2 metal atoms M, of the formula II? wherein W is selected from O, S, NR4, CR5R6, X is N or CR7, Y is selected from O, S, NR8; and further residues are as defined in claim 1, show good light emitting efficiency in electroluminescent applications.Type: GrantFiled: February 4, 2008Date of Patent: March 15, 2016Assignee: BASF SEInventors: Annemarie Wolleb, Heinz Wolleb
-
Patent number: 9284279Abstract: Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.Type: GrantFiled: August 22, 2014Date of Patent: March 15, 2016Assignee: Afferent Pharmaceuticals, Inc.Inventors: Anthony P. Ford, Bruce G. McCarthy
-
Patent number: 9284280Abstract: A method is provided in which Form-I crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide is administered as an active ingredient to a subject for the purpose of treating or preventing certain diseases, disorders, and symptoms, or for promoting angiogenesis or gene therapy. The Form-I crystal exhibits diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2? when the spectrum is obtained by using Cu K? radiation: 9.4 degrees, 9.8 degrees, 17.2 degrees, and 19.4 degrees.Type: GrantFiled: January 22, 2014Date of Patent: March 15, 2016Assignee: NIPPON SHINYAKU CO., LTD.Inventor: Hideyuki Itou
-
Patent number: 9284281Abstract: Disclosed are naphtho[2,3-f]quinoxaline compounds and pharmaceutical composition thereof. The compounds of the invention have been demonstrated as having analgesic effects and therefore may be applicable for use as a novel agent in relieving acute or chronic pain.Type: GrantFiled: September 16, 2014Date of Patent: March 15, 2016Assignee: NATIONAL CENTRAL UNIVERSITYInventors: Wei-Hsin Sun, Shir-Ly Huang, Hsu-Shan Hunag
-
Patent number: 9284282Abstract: A TAF compound that can have substitutions on either of the two benzene rings and/or the C-5 position of the triazole to alter the properties of the TAF compound can be wherein X can be H, an aromatic group, a hetero aromatic group, an alkyl or any substituted alkyl group, ketone, aldyhyde, carboxylic acid derivatives; Y1, Y2, Y3, Y4, and Y5 can be one or more of H, aromatic groups, hetero aromatic groups, alkyl or any substituted alkyl groups, ketone, aldyhyde, or carboxylic acid derivatives; and Z1, Z2, Z3, Z4 and Z5 can be one or more of H aromatic groups, hetero aromatic groups, alkyl or any substituted alkyl groups, ketone, aldyhyde, or carboxylic acid derivatives. Included is a preparation of the TAF compound and use as a photoactive and/or catalyst.Type: GrantFiled: June 25, 2014Date of Patent: March 15, 2016Assignee: West Virginia UniversityInventor: Xiaodong Shi