Patents Issued in March 22, 2016
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Patent number: 9290400Abstract: To provide granules which are to be used as raw material for aluminosilicate glass and which are capable of reducing formation of fine powder during the production thereof, and a process for their production. Granules of a glass raw material mixture comprising at least silica sand and aluminum oxide, which are to be used for production of glass, characterized in that when the granules in such a state that the water content is at most 2 mass % are subjected to screening using a sieve having 1 mm openings, D50 representing the volume cumulative median diameter in the particle size distribution curve of particles passed through the sieve, is from 350 to 5,000 ?m, and in the particle size distribution curve of water-insoluble components in the granules, the proportion of particles exceeding 50 ?m in diameter is at most 6 vol %, and D90 representing the 90% volume cumulative particle diameter from the smaller particle size side is at most 45 ?m.Type: GrantFiled: June 23, 2014Date of Patent: March 22, 2016Assignee: Asahi Glass Company, LimitedInventors: Yasuhiro Kunisa, Nobuhiro Shinohara
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Patent number: 9290401Abstract: An assembly for controlling the weight of a glass gob on a glassware molding machine has a punch for at least partly penetrating the gob and controlled by a fluidic linear actuator having an outer sleeve of paramagnetic material, and a piston which slides inside the sleeve; the piston being connected integrally to the punch; and movement of the piston being controlled by a linear transducer having a movable member fitted to the piston, and a fixed member located outside the sleeve.Type: GrantFiled: June 28, 2013Date of Patent: March 22, 2016Assignee: Bottero S.p.A.Inventors: Zdenko Kuz, Bruno Viada, Maurizio Barolo
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Patent number: 9290402Abstract: Disclosed is a method for producing a technical glass part, particularly meeting high requirements with respect to contour accuracy and surface quality, particularly a precision lens, wherein a blank including a cast-on section is produced using an injection molding process, wherein the blank is cooled down and subsequently heated, and wherein the blank subsequently is blank molded, particularly on both sides, into a technical glass part meeting high requirements with respect to contour accuracy and surface quality, particularly a precision lens.Type: GrantFiled: July 26, 2011Date of Patent: March 22, 2016Assignee: DOCTER OPTICS SEInventors: Peter Mühle, Wolfram Wintzer
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Patent number: 9290403Abstract: Repositionable heater assemblies and methods of controlling temperature of glass in production lines using the repositionable heater assemblies are disclosed. The repositionable heater assembly includes a support frame, a first sled and a second sled each coupled to the support frame with bearing members that allow the first sled and the second sled to translate in a longitudinal direction. Each of the first sled and the second sled include at least one heating element, where the heating elements are spaced apart from the glass ribbon a spacing distance. The first and second sleds are movable in the longitudinal direction to controlling the spacing distance between the heating elements of the first sled and the second sled and the glass ribbon to manage temperature of the glass ribbon.Type: GrantFiled: February 25, 2013Date of Patent: March 22, 2016Assignee: CORNING INCORPORATEDInventors: James Gary Anderson, Steven Roy Burdette, Vladislav Yuryevich Golyatin, Jon Anthony Passmore, George Clinton Shay
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Patent number: 9290404Abstract: A method to form quartz glass ingots of ultra low contamination and defect levels by firing a high-purity quartz form as the feedstock, wherein the quartz glass ingot is free-formed on a platen rotating concentrically with the feedstock quartz article.Type: GrantFiled: January 15, 2014Date of Patent: March 22, 2016Assignee: Momentive Performance Materials Inc.Inventors: Michael Peter Winnen, Todd R. Springer
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Patent number: 9290405Abstract: One embodiment of the disclosure relates to a method of making an optical fiber comprising the steps of: (i) exposing a silica based preform with at least one porous glass region having soot density of ? to a gas mixture comprising SiCl4 having SiCl4 mole fraction ySiCl4 at a doping temperature Tdop such that parameter X is larger than 0.03 to form the chlorine treated preform, wherein X = 1 1 + [ ( ? ? s - ? ) ? 0.209748 ? T dop ? Exp ? [ - 5435.33 / T dop ] y SiCl ? ? 4 3 / 4 ] and ?s is the density of the fully densified soot layer; and (ii) exposing the chlorine treated preform to temperatures above 1400° C. to completely sinter the preform to produce sintered optical fiber preform with a chlorine doped region; and (iii) drawing an optical fiber from the sintered optical preform.Type: GrantFiled: August 25, 2014Date of Patent: March 22, 2016Assignee: Corning IncorporatedInventors: Brian Lee Harper, Rostislav Radiyevich Khrapko, Snigdharaj Kumar Mishra, Sonya Marie Raney, Pushkar Tandon
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Patent number: 9290406Abstract: A method for producing an optical fiber is provided. The method includes the steps of drawing an optical fiber from a heated glass source in a furnace and introducing index perturbations to the optical fiber via a plurality of perturbation sources arranged at a plurality of different azimuthal locations. The index perturbations are introduced synchronously at different locations along the axial length of the fiber by the plurality of perturbation sources in a generally helical pattern on the outside surface of the fiber in one embodiment. According to another embodiment, the index perturbations are introduced by the plurality of perturbation sources at different frequencies.Type: GrantFiled: August 16, 2012Date of Patent: March 22, 2016Assignee: Corning IncorporatedInventors: Xin Chen, Charles Frederick Laing, Ming-Jun Li, Anping Liu, Eric John Mozdy, Joseph Doull Thaler
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Patent number: 9290407Abstract: A glass and an enclosure, including windows, cover plates, and substrates for mobile electronic devices comprising the glass. The glass has a crack initiation threshold that is sufficient to withstand direct impact, has a retained strength following abrasion that is greater than soda lime and alkali aluminosilicate glasses, and is resistant to damage when scratched. The enclosure includes cover plates, windows, screens, and casings for mobile electronic devices and information terminal devices.Type: GrantFiled: November 18, 2013Date of Patent: March 22, 2016Assignee: Corning IncorporatedInventors: Kristen L. Barefoot, Matthew John Dejneka, Sinue Gomez, Timothy Michael Gross, Nagaraja Shashidhar
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Patent number: 9290408Abstract: Certain example embodiments relate to improved seals for glass articles. Certain example embodiments relate to a composition used for sealing an insulted glass unit. In certain example embodiments the composition includes vanadium oxide, barium oxide, zinc oxide, and at least one additional additive. For instance, another additive that is a different metal oxide or different metal chloride may be provided. In certain example embodiments, a vacuum insulated glass unit includes first and second glass substrates that are sealed together with a seal that includes the above-described composition.Type: GrantFiled: September 21, 2011Date of Patent: March 22, 2016Assignee: Guardian Industries Corp.Inventor: Timothy Alan Dennis
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Patent number: 9290409Abstract: The invention provides a glass ceramic glaze composition manufactured using conventional raw material and one or more waste materials, wherein the waste materials are capable of producing glass forming oxides and glass modifying oxides. The waste materials are selected from a group that includes cullet, pozzolanic waste and fly ash. The invention also provides a method for manufacturing the glass ceramic glaze composition. Further, the invention provides different methods of glazing a glass ceramic substrate using the glass ceramic glaze composition.Type: GrantFiled: December 23, 2012Date of Patent: March 22, 2016Assignee: King Abdulazia City for Science and Technology (KACST)Inventors: Mohammed A Binhussain, Paolo Colombo, Enrico Bernardo, Majed A Binmajed, Mauro Marangoni, Hamad H Atalasi, Amer M Alajmi, Abdulaziz Altamimi
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Patent number: 9290410Abstract: The disclosure is directed to a method for controlling the sludge that is generated during the wet acid etching of glass articles. The four Factors that need to be controlled are (i) the dissolved glass level A; (ii) the HF concentration B; (iii) the second acid concentration C, the second acid being a strong acid, and (iv) the solubility constant D of the precipitate, Ksp, which is controlled by changing temperature or ionic strength. The disclosed method utilized HF as the etchant and a strong acid selected from the group consisting of HCI, H2SO4.HNO3 and HCIO4.Type: GrantFiled: May 28, 2013Date of Patent: March 22, 2016Assignee: CORNING INCORPORATEDInventors: Yuhui Jin, Jun Hou, Mehmet Derya Tetiker, Shyamala Shanmugam
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Patent number: 9290412Abstract: To provide a method of processing a tempered glass in a simple and appropriate manner while a degree of freedom of processing is secured. Vibration of the processing device is controlled in a feedback fashion such that a vibration amplitude and a vibration frequency of the processing device approach to a target vibration amplitude and a target vibration frequency not to keep them in a range where a value of worsening the quality is generated. Further, a specified sample cycle of 0.3 msec or less in the feedback control is employed.Type: GrantFiled: August 31, 2012Date of Patent: March 22, 2016Assignee: CERON Technologies Inc.Inventor: Hironori Minami
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Patent number: 9290413Abstract: An aluminosilicate glass article having a high compressive stress layer. The glass article comprises at least about 50 mol % SiO2 and at least about 11 mol % Na2O, and has a layer under a compressive stress of at least about 900 MPa and the depth of layer that extends at least about 30 ?m from the surface of the glass article into the glass. A method of making such a glass article is also provided.Type: GrantFiled: June 26, 2012Date of Patent: March 22, 2016Assignee: CORNING INCORPORATEDInventors: Matthew John Dejneka, Adam James Ellison, John Christopher Mauro
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Patent number: 9290414Abstract: The present invention relates to a glass strand having a coating including a polymer chosen from vinyl acetate/vinyl chloride copolymers, polyvinyl chloride and polyvinylidene chloride, and a silane of formula (I).Type: GrantFiled: March 28, 2012Date of Patent: March 22, 2016Assignee: SAINT-GOBAIN ADFORSInventors: Benjamin Blanchard, Katarzyna Chuda
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Patent number: 9290415Abstract: The fire resistant cementitious composite is an engineered cementitious composite (EEC) having both flexural strength and fire resistant properties. The fire resistant cementitious composite includes a binder mixture formed from Portland cement and fly ash, sand, polyvinyl alcohol fibers, a polycarboxylic ether polymer and water. In the binder mixture, a weight ratio of the fly ash to the Portland cement is between approximately 1.0 and approximately 1.3. A weight ratio of the Portland cement to the sand is between approximately 0.85 and approximately 1.0. A weight ratio of the water to the binder mixture is between approximately 0.28 and approximately 0.33. The sand is preferably Arabian Gulf dune sand.Type: GrantFiled: July 1, 2015Date of Patent: March 22, 2016Assignee: KING SAUD UNIVERSITYInventors: Mohammad Iqbal Khan, Galal Fares, Shehab Eldin Mohamed Mourad
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Patent number: 9290416Abstract: A geopolymer concrete prepared by predicting a mechanical property of a geopolymer concrete formed with each of a plurality of fly ash materials, selecting as a source material for the geopolymer concrete one of the fly ash materials that yields a predicted value of the mechanical property that is equal to or greater than a target value for the mechanical property, and mixing the fly ash source material with an alkaline activator solution, a fine aggregate, and a coarse aggregate. The prediction of the mechanical property includes measuring one or more properties of each of the plurality of fly ash materials, calculating predicted values of the mechanical property for geopolymer concretes formed with each of the plurality of fly ash materials using a predetermined equation relating the one or more properties of the plurality of fly ash materials to predicted values of the mechanical property of the geopolymer concrete.Type: GrantFiled: August 5, 2015Date of Patent: March 22, 2016Assignee: Louisiana Tech Research CorporationInventors: Erez Nissim Allouche, Eleazar Ivan Diaz-Loya
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Patent number: 9290417Abstract: In a composter having a horizontally elongated rotating drum, material is fed into the drum through an opening in a stationary end plate having an annular marginal area which overlaps, in sealing relationship, an annular intake end wall of the drum. Material passes through a central opening in an annular exit end wall of the drum, and falls by gravity onto a cylindrical screen which is fixed to, and rotates with, the exit end wall. The annular end walls are in axial register with, and surrounded by, external trunnions on the drum which ride on pairs of supporting rollers. Frusto-conical rings are welded to the end walls, and to the inside of the drum at locations opposite the edges of the trunnion rings to reduce metal fatigue. The exit end rollers allow for axial expansion of the drum. The interior wall the drum is lined with a rubber.Type: GrantFiled: August 8, 2014Date of Patent: March 22, 2016Assignee: Rotary Composters, LLCInventors: Kenton Good, Kurtis Good, Daniel Gonzalez
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Patent number: 9290418Abstract: The present invention is directed to an explosive composition comprised of heavy ANFO and expanded polymeric beads that have a density that is less than the density of the heavy ANFO. The expanded polymeric beads have a size that is determined or based on the size of ammonium nitrate prills used in the heavy ANFO portion of the composition. In one embodiment, the expanded polymeric beads that are utilized in the composition are at least 70% of the lower limit of the mesh size of the predominant ammonium nitrate prill mesh size. In another embodiment, the expanded polymeric beads are at least 70% of a size that is related to the average mesh size of the ammonium nitrate prills.Type: GrantFiled: April 14, 2014Date of Patent: March 22, 2016Assignee: LDE CorporationInventor: Kevin H. Waldock
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Patent number: 9290419Abstract: A duplex firing initiator for an airbag inflator includes both a primary initiator and a secondary initiator for electrical connection to a Restraint Control Module. In the duplex firing initiator, current is conducted in a forward polarity through the primary initiator to actuate the primary initiator and current is conducted in a reverse polarity through the secondary initiator to actuate at least the secondary initiator.Type: GrantFiled: November 29, 2012Date of Patent: March 22, 2016Assignee: Autoliv ASP, Inc.Inventors: Dario G. Brisighella, Jr., Scott C. Gordon, Vincent Colarossi
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Patent number: 9290420Abstract: A portable device for rapidly inflating an inflatable bag is disclosed, which comprises at least one inlet intended to be connected to a source of compressed gas, in order to allow this gas to expand into an air intake chamber, the inlet being associated with a mechanism that triggers the release of the compressed gas to the air intake chamber, the latter having an opening allowing atmospheric air to be admitted and an outlet intended to be connected to the bag that is to be inflated. The device further comprises an intermediate distribution chamber for the compressed gas, which chamber is arranged between the inlet and the air intake chamber in order to connect the one to the other, and ejection holes arranged so as to open into a lateral wall of the air intake chamber in order to connect the latter to the intermediate distribution chamber.Type: GrantFiled: July 19, 2012Date of Patent: March 22, 2016Assignee: RAS TECHNOLOGY SÀRLInventors: Marc-Antoine Schaer, Robert Graham, Laurent Raeber
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Patent number: 9290421Abstract: The present invention relates to a compound having formula (I): wherein: —X is in particular 125I Or 211At; —R1 and R?1 are independently from each other chosen preferably from the group consisting of electron-withdrawing groups and alkyl groups; —R2 is chosen from the group consisting of: H, alkyl groups, functional groups being able to bind a vector, and functional groups having targeting properties which make the compound of the invention a vector itself; —Z is a heteroatom, R5, R8 and R9 are preferably H; —Y is preferably an electron withdrawing group.Type: GrantFiled: February 2, 2011Date of Patent: March 22, 2016Assignees: Institut National de la Santé de la Recherche Medicalé, Université de Nantes, CHU NantesInventors: Jean-Francois Gestin, Francois Guerard, Alain Faivre-Chauvet
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Patent number: 9290422Abstract: A hybrid plant and method for producing liquid fuel product from hydrogen and carbon monoxide containing streams produced by gasifying solid carbonaceous feedstock and steam reforming of light fossil fuels. When a gasification unit in the hybrid plant is operating at reduced capacity or is not operational, oxygen that would have been used in the gasification unit is diverted to a light fossil fuel conversion unit containing an autothermal reformer to increase H2-rich syngas flow to a liquid fuel production unit and maintain liquid fuel production at near nameplate capacity.Type: GrantFiled: November 27, 2012Date of Patent: March 22, 2016Assignee: PRAXAIR TECHNOLOGY, INC.Inventors: Raymond F. Drnevich, Shrikar Chakravarti, Minish M. Shah
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Patent number: 9290423Abstract: A renewable fuel may be obtained from a bio-oil containing C3-C5 oxygenates. In a first step, the bio-oil is subjected to a condensation reaction in which the oxygenates undergo a carbon-carbon bond forming reaction to produce a stream containing C6+ oxygenates. In a second step, the stream is hydrotreated to produce C6+ hydrocarbons.Type: GrantFiled: November 19, 2012Date of Patent: March 22, 2016Assignee: KiOR, LLCInventors: Jeffrey C Trewella, Edward J Smith, Vicente Sanchez, Brent Moore, Stephen J. McGovern
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Patent number: 9290424Abstract: In certain aspects, the present invention relates to methods for increasing the cost efficiency and safety of the hydrogenation of a fluorinated olefin by controlling the reaction conditions and parameters. In further aspects, the hydrogenation reaction is provided in a two stage reaction wherein the reactant amounts, temperature and other parameters are controlled such that the conversion percentage, selectivity, and reaction parameters are all within commercially acceptable levels.Type: GrantFiled: March 14, 2013Date of Patent: March 22, 2016Assignee: HONEYWELL INTERNATIONAL INC.Inventors: Stephen A. Cottrell, John J. Senetar, Hsueh S. Tung, Daniel C. Merkel, Yuon Chiu, Haluk Kopkalli
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Patent number: 9290425Abstract: Higher mixed alcohols are produced from syngas contacting a catalyst in a reactor. The catalyst has a first component of molybdenum or tungsten, a second component of vanadium, a third component of iron, cobalt, nickel or palladium and optionally a fourth component of a promoter. The first component forms alcohols, while the vanadium and the third component stimulates carbon chain growth to produce higher alcohols.Type: GrantFiled: June 17, 2014Date of Patent: March 22, 2016Assignee: STANDARD ALCOHOL COMPANY OF AMERICA, INC.Inventors: Peter J. Tijm, Rex R. Stevens
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Patent number: 9290426Abstract: A system and a method for forming oxygenates from a non-catalytic reaction. A hydrocarbon gas and an oxygen-containing gas are fed into a mixer and then heated to form a reactant gas stream. The reactant gas stream is fed into a fluidized bed reactor where the reaction of the gases occurs by oxidization to produce oxygenates. The oxygenate products are then removed from the reactor.Type: GrantFiled: May 9, 2013Date of Patent: March 22, 2016Assignee: Stranded Solutions, LLCInventor: Nathan Pawlak
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Patent number: 9290427Abstract: The present invention relates to the field of anti-invasive compounds and methods for predicting the anti-invasive activity of said compounds, as well as their use in the prevention and/or treatment of diseases associated with undesired cell invasion; in particular, this invention relates to the field of anti-invasive chalcone-like compounds.Type: GrantFiled: January 30, 2013Date of Patent: March 22, 2016Assignee: Universiteit GentInventors: Marc Bracke, Christian Stevens, Tine De Ryck, Bart Roman, Barbara Vanhoecke
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Patent number: 9290428Abstract: The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R represents one or more groups independently selected from fluorine, chlorine, bromine, and iodine, said process comprising the cyclopropanation of a compound of formula (II) with ethylene carbonate or ethylene sulfate: wherein X is chlorine, bromine, iodine or a triflate group (CF3SO3) or a group wherein R is as defined above and G is —CN or —COOR2 wherein R2 is a C1-C4 straight or branched alkyl chain.Type: GrantFiled: June 23, 2014Date of Patent: March 22, 2016Assignee: CHIESI FARMACEUTICI S.p.A.Inventors: Massimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
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Patent number: 9290429Abstract: The present invention relates to the field of converting carbohydrates into levulinic acid, a platform chemical for many chemical end products. More specifically the invention relates to a method for converting carbohydrates such as mono-, di- or polysaccharides, obtained from for example biomass production into a suitable levulinic acid ester in the presence of a zeolite or zeotype catalyst and a suitable alcohol, and the ester may be further converted into levulinic acid if desired.Type: GrantFiled: August 2, 2013Date of Patent: March 22, 2016Assignee: DANMARKS TEKNISKE UNIVERSITETInventors: Shunmugavel Saravanamurugan, Anders Riisager
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Patent number: 9290430Abstract: Technical grade acrylic acid derived from renewable resources utilizing a homogeneous nickel catalyst system by a process including reacting lactide with acetic acid to form 2-acetoxypropionic acid in the presence of a homogeneous nickel catalyst, pyrolyzing, with or without a catalyst, the 2-acetoxypropionic acid to acrylic acid and acetic acid, condensing and collecting the pyrolysis products in the presence of polymerization inhibitor(s) and purifying the acrylic acid by distillation in the presence of polymerization inhibitor(s). Acrylic acid and methyl acrylate are produced from methyl 2-acetoxypropionate which comes from fermentation derived lactic acid. The disclosed process will produce a “green” (i.e. renewable resources derived) acrylic acid and methyl acrylate ester.Type: GrantFiled: April 20, 2015Date of Patent: March 22, 2016Assignee: SGA Polymers, LLCInventors: Olan S. Fruchey, Thomas A. Malisezewski, John E. Sawyer
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Patent number: 9290431Abstract: This invention relates to a process of preparing highly pure, non-yellowing (meth)acrylic acid necessary for high-tech applications requiring long-tem color stability in the presence of amines. Process for the preparation of highly pure, non-yellowing (meth)acrylic acid comprising the steps: f) Condensation of a (meth)acrylic acid-containing gas phase obtained via a gas phase oxidation process of a C4-compound to generate an aqueous (meth)acrylic acid solution g) Separation of the (meth)acrylic acid from the aqueous (meth)acrylic acid solution to obtain crude (meth)acrylic acid h) Rectification of the crude (meth)acrylic acid to obtain pure (meth)acrylic acid via a sidestream outlet of the rectification column i) Treatment of the pure (meth)acrylic acid generated in step c) with an ion exchange resin j) Distillation of the (meth)acrylic acid generated in step d).Type: GrantFiled: April 22, 2013Date of Patent: March 22, 2016Assignee: EVONIK RÖHM GmbHInventors: Zhengfeng Zhang, Gerhard Koelbl, Lorenza Sartorelli, Horst Hiltner, Huisheng Wang, Mirko Michel
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Patent number: 9290432Abstract: The subject of the invention is process the preparation of travoprost of formula (I) characterized by that the free acid of formula (II) is a.) activated with 2-chloro-1,3-dimethyl-imidazolinium chloride (DMC) and the resulting activated carboxylic acid intermediate is reacted with isopropyl alcohol, or b.) reacted with alkyl haloformate and the resulting mixed anhydride is reacted with isopropyl alcohol, or c.) activated with a straight or branched C1-8 dialkyl dicarbonate and reacted with isopropanol in the presence of water-free magnesium salt.Type: GrantFiled: November 26, 2013Date of Patent: March 22, 2016Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Zoltán Bischof, Ádám Bódis, Mária Kömüves-Mars, Gábor Havasi
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Patent number: 9290433Abstract: A single stage straight forward process for extraction and isolation of lutein ester from the dried petals of marigold flowers Tagetes species using the carbondioxide as the supercritical fluid was developed. The pressure maintained for the extraction was up to 625 bar and at temperature up to 750 Centigrade. Lutein ester of high strength and purity up to 70% was achieved for the first time in single stage from the dried petals of marigold flowers-Tagetes species while enrichment of the lutein ester content up to 98% was achieved by crystallization of the lutein ester obtained from supercritical carbon dioxide extract (SCFE). The high strength and purified lutein ester isolated by supercritical fluid-single stage extraction process are free from saturated fat, oil, waxy impurities and serve as a safe source of nutritional supplement for human consumption and color additive for human foods.Type: GrantFiled: January 12, 2012Date of Patent: March 22, 2016Assignee: INDIA GLYCOLS LIMITEDInventors: Uma Shankar Bhartia, Gopu Bala Show Reddy
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Patent number: 9290434Abstract: The present invention relates to the use of a composition comprising a partial ester of a carboxylic acid and a polyhydric alcohol as a lubricity improver, wherein as the polyhydric alcohol use is made of a diglycerol composition which comprises at least 75.0 wt. % of diglycerol, wherein as the carboxylic acid use is made of a fatty acid composition which contains at least one C8-C22 fatty acid or a mixture of two or more thereof.Type: GrantFiled: May 6, 2011Date of Patent: March 22, 2016Assignee: OLEONInventors: Ben Verhaeghe, Lieven Van Hecke, Dirk Packet
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Patent number: 9290435Abstract: Disclosed is a molecular glass of a spirofluorene derivative having a molecular structure as follows: formula (I), wherein each of R1-R12 is a hydrogen atom, a hydroxyl group, a methoxyl group or an acid-sensitive substituent; substituents R1˜R12 can be identical or different, but on the same benzene ring the substituents cannot all be hydrogen atoms. The molecular glass has a good solubility in various polar solvents, is suitable to be made into a film; meanwhile the molecular glass has a very high glass transition temperature and meets the requirements of the photolithography processing technology. Also disclosed is a preparation method of the above-mentioned molecular glass of a spirofluorene derivative. The synthetic process of the method is simple and suitable for industrialization.Type: GrantFiled: January 22, 2013Date of Patent: March 22, 2016Assignee: Technical Institute of Physics and Chemistry of the Chinese Academy of SciencesInventors: Yi Li, Qingshan Hao, Jinping Chen, Yi Zeng, Tianjun Yu
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Patent number: 9290436Abstract: The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.Type: GrantFiled: December 13, 2012Date of Patent: March 22, 2016Assignee: Elizabeth Arden, Inc.Inventors: Falko Diedrich, Birgit Neudecker, Eberhard Wieland, Joseph A. Lewis, II, Joseph C. DiNardo, Andrew S. Thompson, James Alan Kerschen, Peter C. Wade
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Patent number: 9290437Abstract: A bromine/nitro moiety linked into the backbone of an ester or other compound over a wide range of occurrence rates provides antimicrobial, bio-resistant and fungal resistant properties for metal working fluids (MWF)s and other coatings. The moiety can be have the bromo and nitro groups linked to the same or different carbon atoms. The present invention also relates to urethanes, urea, amides, imides, carbonates, ethers, siloxanes, and many other types of linkages essential to MWF bases.Type: GrantFiled: December 2, 2014Date of Patent: March 22, 2016Inventor: Thomas Daly
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Patent number: 9290438Abstract: The present invention relates to a method of producing aromatic amines by hydrogenation of aromatic nitro compounds. This method provides a reactor containing a hydrogenation catalyst; supplies aromatic nitro compounds and hydrogen to the reactor and contacts them with a hydrogenation catalyst, in which the hydrogen which is supplied to the reactor is by a compressor and the compressor contains an operating fluid which at least partially contacts the hydrogen; and regenerates the hydrogenation catalyst by heating and contacting it with oxygen. Particular operating liquids are subsequently exchanged.Type: GrantFiled: April 12, 2013Date of Patent: March 22, 2016Assignee: Bayer MaterialScience AGInventors: Michael Merkel, Thomas Knauf, Cliff Andre Peters, Thorsten Schmidt
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Patent number: 9290439Abstract: The present patent application relates to a process for preparing, cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which R1 and R2, which may be identical or different, are each a (C1-C6)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.Type: GrantFiled: September 9, 2013Date of Patent: March 22, 2016Assignee: Produits Chimiques Auxiliaires et de SyntheseInventors: Jean-Marie Schneider, Jonathan Madec, Sergio Kreimerman, Gerard Guillamot
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Patent number: 9290440Abstract: Provided is a pharmaceutical agent containing a compound represented by General Formula (1), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein A represents a C1-C3 linear alkylene group, in which one methylene group is optionally substituted with O or S; n represents an integer of from 3 to 5; X1 and X2 each independently represent CH or N; W1 and W2 each independently represent a carboxyl group or a tetrazolyl group; V represents a C1-C8 linear or branched alkylene group, in which one methylene group is optionally substituted with O or S; and R represents a substituted phenyl group, for example.Type: GrantFiled: April 15, 2013Date of Patent: March 22, 2016Assignee: TOA EIYO LTD.Inventors: Kazuhiro Uemoto, Yoshimichi Sato, Naoki Okada, Emiko Iimori, Masayuki Kageyama
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Patent number: 9290441Abstract: A process for preparing amides by reacting a primary amine and a primary alcohol in the presence of a Ruthenium complex to generate the amide and molecular hydrogen. Primary amines are directly acylated by equimolar amounts of alcohols to produce amides and molecular hydrogen (the only byproduct) in high yields and high turnover numbers. Also disclosed are processes for hydrogenation of amides to alcohols and amines; hydrogenation of organic carbonates to alcohols; hydrogenation of carbamates or urea derivatives to alcohols and amines; amidation of esters; acylation of alcohols using esters; coupling of alcohols with water and a base to form carboxylic acids; dehydrogenation of beta-amino alcohols to form pyrazines and cyclic dipeptides; and dehydrogenation of secondary alcohols to ketones. These reactions are catalyzed by a Ruthenium complex which is based on a dearomatized PNN-type ligand of formula A1 or precursors thereof of formulae A2 or A3.Type: GrantFiled: May 14, 2012Date of Patent: March 22, 2016Assignee: Yeda Research and Development Co. Ltd.Inventors: David Milstein, Chidambaram Gunanathan, Yehoshua Ben-David, Ekambaram Balaraman, Boopathy Gnanaprakasam, Jing Zhang
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Patent number: 9290442Abstract: A process for synthesizing 4-amino-2,4-dioxobutanoic acid involves reacting diethyl oxalate with an alkoxide in ethanol to form a reaction mixture, and afterward adding ethyl cyanoacetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl 2-cyano-3-hydroxy-butenedioate, and then isolating the diethyl 2-cyano-3-hydroxy-butenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with an aqueous hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoic acid.Type: GrantFiled: September 15, 2014Date of Patent: March 22, 2016Assignees: Los Alamos National Security, LLC, New Mexico Highlands UniversityInventors: Pat J. Unkefer, Rodolfo A. Martinez, David R. Glass
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Patent number: 9290443Abstract: A process for synthesizing 4-amino-2,4-dioxobutanoate involves reacting a dialkyl oxalate with an alkoxide in ethanol to form a reaction mixture, and afterward adding an alkyl cyano acetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl 2-cyano-3-hydroxy-butenedioate, and then isolating the diethyl 2-cyano-3-hydroxy-butenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with an aqueous hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoate. The 4-amino-2,4-dioxobutanoate may be acidified into 4-amino-2,4-dioxobutanoic acid.Type: GrantFiled: September 17, 2014Date of Patent: March 22, 2016Assignees: Los Alamos National Security, LLC, New Mexico Highlands UniversityInventors: Pat J. Unkefer, Rodolfo A. Martinez, David R. Glass
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Patent number: 9290444Abstract: The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.Type: GrantFiled: March 26, 2014Date of Patent: March 22, 2016Assignee: AbbVie Inc.Inventors: R. Scott Bitner, Kaitlin E. Browman, Michael E. Brune, Steven Fung, Peer B. Jacobson, Lynne E. Rueter, Marina I. Strakhova, Jiahong Wang, Jyoti R. Patel, Qi Shuai, James T. Link, Jeffrey J. Rohde, Jurgen Dinges, Bryan K. Sorensen, Martin Winn, Hong Yong, Vince S. Yeh
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Patent number: 9290445Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.Type: GrantFiled: October 19, 2009Date of Patent: March 22, 2016Assignee: XenoPort, Inc.Inventors: Stephen P. Raillard, Adam Mann, Suresh K. Manthati, Randall A. Scheuerman, Tono Estrada, Mark Q. Nguyen, Cindy X Zhou
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Patent number: 9290446Abstract: The invention provides electrophilic monohalomethylating reagents, methods for their preparation and methods for preparation of monohalomethylated biologically active compounds using such reagents. Typical monohalomethyl groups transferred are FH2C—, CIH2C— and others. The reagents used for transferal of the groups are described by Formulae A-D: wherein: X=F, Cl, Br, I, sulfonate esters, phosphate esters or another leaving group; R11=tetrafluoroborates, inflates, halogen, perchlorate, sulfates, phosphates or carbonates The other variables are as defined in the claims.Type: GrantFiled: October 27, 2011Date of Patent: March 22, 2016Assignee: Hovione Inter LimitedInventor: Emilia Perpetua Tavares Leitao
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Patent number: 9290447Abstract: This invention discloses (20R) and (20S)-24-(p-toluenesulfonyloxy)-25,26,27-trinorvitamin D3 analogs, and especially (20R)-25,26,27-trinor-24-(p-methylphenylsulfonate)-vitamin D3, its biological activities, and pharmaceutical uses therefor. This compound exhibits relatively little calcemic activity and does not promote cellular differentiation of HL-60 leukemia cells, but rather kills the cells. This cell death activity is found in small cell lung carcinoma also, but not in prostate, bone or ovarian cancer cells. This compound thus causes specific cell death in the absence of changes in calcium levels and without general toxicity in an animal. Therefore it might serve as a useful therapy for treatment of some forms of cancer, such as leukemia and lung cancer.Type: GrantFiled: April 19, 2012Date of Patent: March 22, 2016Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Margaret Clagett-Dame, Lori A. Plum, Rafal Barycki
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Patent number: 9290448Abstract: The present invention relates to novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds of the invention are storage stable, water soluble and have low to no odor. Further, the compounds of the present invention can be formed from non-petroleum based renewable materials. The compounds of the present invention can be used as antimicrobials, and bleaching agents. The compounds of the present invention are also suitable for use as coupling agents.Type: GrantFiled: June 27, 2014Date of Patent: March 22, 2016Assignee: ECOLAB USA, INC.Inventors: Junzhong Li, Richard Staub, David D. McSherry, Keith G. Lascotte, Steven J. Lange, Frank Everts
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Patent number: 9290449Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.Type: GrantFiled: April 11, 2013Date of Patent: March 22, 2016Assignee: Georgetown UniversityInventors: Jeffrey A. Toretsky, Milton Lang Brown, Perrer N. Tosso, Aykut Uren, Yali Kong
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Patent number: 9290450Abstract: Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.Type: GrantFiled: April 28, 2014Date of Patent: March 22, 2016Assignee: InterMune, Inc.Inventors: Karl Kossen, Scott D. Seiwert, Vladimir Serebryany, Donald Ruhrmund, Leonid D. Beigelman, Luca Francesco Mario Raveglia, Stefania Vallese, Ivana Bianchi, Tao Hu