Abstract: An apparatus is disclosed for applying heat and pressure to a contusion. The disclosed apparatus comprises a housing, at least one roller, and a heating element. The heating element is configured to heat the roller, and the roller is configured to be applied to a contusion.

Abstract: A physical therapy device includes an axle member having first and second distal ends, a first wheel of a first diameter disposed about the axle member, a second wheel of the first diameter disposed about the axle member, a first rounded end cap massager disposed at least partially over the first distal end of the axle member, the first rounded end cap massager having a second diameter that is less than the first diameter, and a second rounded end cap massager disposed at least partially over the second distal end of the axle member.

Abstract: Systems and methods for inhibiting an occurrence of an apneic or hypoxic event are disclosed. Physiological data is received from a subject and analyzed to detect an impending apneic event or an impending hypoxic event. A stimulation is applied to the subject to inhibit occurrence of the impending apneic or hypoxic event after an occurrence of a predetermined condition. The physiological data can include respiratory data, cardiological data, or a combination thereof. The analyzing includes use of a point-process model and gross body movement data of the subject. Therapeutic effectiveness of the stimulation is increased by accounting for gross body movements of the patient.

Abstract: Medical equipment (200) for High Frequency Chest Wall Oscillation (HFCWO) treatment configured to be worn on a thorax and arranged to apply repetitive compressions to the thorax, characterized in that it comprises a plurality of pressure devices (240) to apply the repetitive compressions and comprising each a deformable chamber (308) and at least a port (305, 306) in communication with the chamber (308) configured to let a pressurized fluid flowing alternatively in and out the chamber (308) so that the pressure device (240) alternatively passes from an inflated configuration to a deflated configuration, wherein the pressure device (240) comprises an impact face (311) configured to apply the repetitive compressions against the thorax and wherein the impact face (311) presents at least an elongation that extends along one main direction, the dimension (L) of the impact face (311) along the main direction being greater than three centimeters and being greater than 1.

Abstract: A system for administering a therapeutic treatment to a portion of a patient body. In one embodiment the system includes a pressure sensor, a treatment head, and at least one computer processor in operable electrical communication with both the pressure sensor and treatment head. When a treatment tip of the treatment head is applied against the portion of the patient body, the at least one computer processor receives time dependent pressure readings from the pressure sensor corresponding to pressure applied by the treatment tip against the portion of the patient body. The at least one computer processor calculates a test frequency via an algorithm stored in the system. The system compares the test frequency to treatment plan frequencies and selects treatment plan based on the comparison.

Abstract: A process of massaging a subject is provided that includes the provision of a vibratory massage roller with a user controlled magnitude of vibratory amplitude having a casing with a casing surface extending over a length of the vibratory roller. A series of weights inside the casing may be positioned by the user to vary and control the amplitude of the vibration produced by the roller. A motor is included in the housing and is electrically coupled to a power source. The power source is energized to induce a vibratory amplitude to the surface that varies less than thirty amplitude percent across the central seventy percent of the length. The massage roller is contacted with the subject to massage the subject.

Abstract: A neurophysiological method of treating muscular dysfunction caused by a neurological disorder, such as Parkinson's Disease, includes applying a predetermined pressure to the patient, so as to cause pain inhibition that blocks response to a targeted muscle at the spinal cord level, and translating the patient through a passive range of motion, while causing the pain.

Abstract: A naso/orogastric device having backflow blocking means and comprises a naso/orogastric tube sized and shaped for being disposed within the esophagus so that at least a distal end thereof being placed in the stomach lumen of a patient, at least one elastic esophageal body, positioned along the naso/orogastric tube, having a pressure dependent volume, at least one esophageal sensor that detects fluid around at least one segment of the naso/orogastric tube, and a pressure regulator that regulates a pressure within the elastic esophageal body according to the detection.

Abstract: Described herein are compositions and methods which produce hydrolytically stable resin monomers, bioactive fillers, phosphorus coupling agent and surface coating method, which can be combined to produce new generation dental composites; compositions comprising the same, as well as methods of making and using the same are also described.

Abstract: The invention relates to a blank for producing a dental moulded part such as an inlay, onlay, crown or bridge, and to a method for producing the blank. To be able to machine a dental moulded part, in particular one having thin wall thicknesses, from the blank without difficulty, the blank is designed to consist of a glass ceramic having a density of between 30 and 60% of theoretical density, and of glass-ceramic powder particles with a particle size distribution d90?80 ?m, lithium silicate crystals being present in an amount of 10 to 90% by volume.

Abstract: The present invention relates to a curable dental material, to a cured dental material producible therefrom by polymerization, to a method for producing the curable or cured dental material and to the use of the curable or cured dental material.

Abstract: Dental cement compositions (including two-part compositions), kits, and related methods are used for bonding a dental prosthetic appliance to a tooth. A first part includes an amine activator component and a zinc oxide reactive filler, while a second part includes a polymerization initiator (e.g., benzoyl peroxide) and a polymerizable component having a structure including at least one acrylate or methacrylate group at one end and a carboxylic acid group at another end. A temporary cement composition advantageously exhibits reduced compressive and/or bonding strength relative to permanent cement compositions, which provides sufficient strength to facilitate normal use of the teeth while the provisional appliance is in use, while also facilitating easy removal of the provisional appliance for replacement with a permanent appliance at a later time.

Abstract: An object of the present invention is to provide a filler capable of exhibiting semitransparent foggy effects as in fogged glasses. The present invention provides a filler comprising: a transparent or semitransparent thin platelet-like substrate; a particle layer or coating layer (hereinafter, referred to as a first layer) which is formed on the surface of the thin platelet-like substrate and composed of a hydrous oxide, carbonate, or calcined product thereof, of at least one metal (hereinafter, referred to as a first metal) selected from the group consisting of Mg, Al, and Ca; a coating layer (hereinafter, referred to as a second layer) which coats the thin platelet-like substrate comprising the first layer formed thereon and is composed of an Si hydrous oxide or calcined product thereof; and a coating layer (hereinafter, referred to as a third layer) which coats the second layer and is composed of a Ti hydrous oxide or calcined product thereof.

Abstract: Disclosed herein are foamable gritty foam compositions that can suspend particulate mechanical scrubbers with particles sized from about 100 microns to about 800 microns that is capable of being foamed through a non-aerosol, or unpressurized pump dispenser.

Abstract: An aqueous composition comprising basic aluminium chloride salt, water soluble calcium salt, and amino acid, characterised in that the basic aluminium chloride salt is of formula AI2OH4.4CI1.6 to AI2OH4.9CI1.1 and methods for making such compositions having enhanced antiperspirancy performance.

Abstract: A non-pressurized container that contains one or more of: a foamable composition of minoxidil, or a pharmaceutically acceptable salt thereof, and a dihydrotestosterone blocker in a formulation with a precise density and viscosity to yield a foam with a temperature sensitivity and shear strength designed for inverted application and immediate targeted release at body temperature under a minimal hand applied pressure to the scalp.

Abstract: Sex hormone-binding globulin and/or any fragment thereof for use as a medicament, in particular for use in the treatment of obesity and hepatic steatosis. The invention also relates to the cosmetic use of the sex hormone-binding globulin and/or any fragment thereof for improving the bodily appearance of a mammal with subcutaneous fat herniated or accumulated within the fibrous connective tissue under the skin, in particular the cosmetic use is for cellulite.

Abstract: Disclosed is the a method of effecting skin hydration and enhancing skin barrier function, said method comprising the step of bringing into contact a pentapeptide conjugate of oleanolic acid with skin cells so that the effect of increased cellular communication at the molecular level to bring about gene and protein expression in the cells of the skin that enable hydration and skin barrier functions are realized.

Abstract: The presently disclosed and/or claimed inventive concept(s) relates generally to the use of nonionic hydrophobically modified polysaccharides in personal care and household care compositions. More specifically, but not by way of limitation, the presently disclosed and/or claimed inventive concept(s) relates to the use of hydrophobically-modified cellulose ethers, such as hydrophobically-modified hydroxyethylcellulose (HMHEC) polymers in personal care and household care compositions. These compositions show pronounced syneresis in aqueous solutions or in the presence of surfactants, including nonionic surfactants and anionic surfactants such as lauryl sulfate (LS) and lauryl ether sulfate (LES). It is also contemplated that the surfactants used in the compositions be sulfate free and/or multi-tailed.

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.

Abstract: Disclosed is a pH responsive polymer made with mono-[2-(methacryloyloxy)ethyl]phthalate and/or mono-[2-(methacryloyloxy)ethyl hexahydro]phthalate. Also disclosed is an aqueous coating composition including at least one latex polymer derived from at least one monomer copolymerized or blended with alkali swellable acrylate copolymer. Also provided is an aqueous coating composition including at least one latex polymer derived from at least one monomer blended with alkali swellable acrylate copolymer, at least one pigment, and water. Also provided is a method of preparing an aqueous coating composition such as a latex paint including the above components. Also provided are methods of preparing mono-[2-(methacryloyloxy)ethyl]phthalate. Also provided are compositions and methods using the polymer in hydraulic fracturing, personal care and or home and industrial cleaners.

Abstract: The present invention relates to a cosmetic composition comprising (i) at least one mineral wax in a content ranging from 12% to 40% by weight relative to the total weight of the composition, (ii) at least one fatty acid, (iii) at least one mineral oil, (iv) at least one surfactant, (v) at least one ester of fatty acid and/or of fatty alcohol and (vi) at least one fixing polymer.

Abstract: Methods and apparatus are provided for a heat activated antiperspirant. The heat activated antiperspirant composition includes at least one delayed release component to attract the antiperspirant active ingredient. The at least one delayed release component is a solid up to about 33 degrees Celsius (° C.) and has a melting point of about 33 to 41° C. to release the antiperspirant active ingredient to reduce perspiration.

Abstract: The present invention relates to a topical composition comprising a silicone oil and a porous cross-linked polymethylmethacrylate bead having a particle size Dv0 of greater 0.3 ?m a Dv100 of less than 35 ?m, a Dv50 selected in the range of 6-15 ?m and an oil absorption capacity selected in the range of 1.2-2.5 cc/g, characterized in that the silicone oil constitutes at least 5 wt.-% of the total oil phase of the topical composition. Furthermore the invention relates to the use of such polymethylmethacrylate beads to boost the silicone feel of a cosmetic composition comprising such silicone oils.

Abstract: Provided are: an oil-based thickening agent which is capable of providing an oil-based composition that has a high thickening effect on an oil component such as a silicone oil, while achieving excellent feeling of use; an oil-based thickening composition which contains this oil-based thickening agent and a liquid oil component; and a cosmetic preparation in which this oil-based thickening agent or oil-based thickening composition is blended. An oil-based thickening agent which is composed of a silicone-modified polysaccharide compound represented by formula (1) and a silicone emulsifying agent. (In the formula, PL represents a glucose residue of pullulan; R1 represents a monovalent hydrocarbon group having 1-10 carbon atoms; R2 represents a monovalent hydrocarbon group having 1-10 carbon atoms or a siloxy group represented by —OSi(R3)3; R3 represents a monovalent hydrocarbon group having 1-8 carbon atoms; n is an integer of 1-10; a is 0 or 1; and b is 0, 1 or 2.

Abstract: Some embodiments of the present disclosure include a haircare composition for preventing hair loss and promoting hair regrowth. The haircare composition may include a base composition including lanolin, shea butter, coconut oil, and beeswax, a moisturizer including olive oil, Vitamin E oil, apricot oil, castor oil, and grape-seed oil, a stimulant including menthol, gooseberry extract, sulfur, Vitamin B complex, and black seed oil, and a strengthener including sage essential oil, rosemary essential oil, and peppermint essential oil. The haircare composition may regrow and strengthen hair, resolve baldness, and repair damaged hair follicles.

Abstract: A hair rejuvenating lotion applied to a user's hair to treat and relieve symptoms caused by seborrheic dermatitis. Through use of plant extracts and other supplemental active ingredients, the hair rejuvenating lotion restores hair to a healthy condition, retains color and prevents hair loss. The plant extracts included are from the genera echinops, alchemilla, staphylea, and scorzonera, as well as the plants sophora japonica and nettle. The other supplemental active ingredients include sulfur, ammonium chloride, lead acetate, and castor oil. The base of the hair rejuvenating lotion consists of distilled water, glycerin, and ethyl alcohol. The plant extracts from the genera echinops, alchemilla, staphylea, scorzonera are dissolved into the ethyl alcohol to create a tincture solution. The tincture solution is mixed with the distilled water, glycerin, sulfur, sophora japonica extracts, nettle extracts, ammonium chloride, and castor oil to form the hair rejuvenating lotion.

Abstract: The present invention relates to a composition comprising ex-vivo expanded adipose tissue derived stem cell (ASC) or ex-vivo expanded adipose tissue-derived stem cells (ASC) mixed with harvested fat tissue at a ratio of 5.0×104-2.0×108 ASCs/mL fat; for example 1.0×105-2.0×107 and the use of ex-vivo expanded adipose tissue-derived stem cells or ex-vivo expanded adipose tissue-derived stem cell enriched fat grafts as an agent for cosmetic breast filling/augmentation or for facial filling/reju-venation.

Abstract: Cosmetic, pharmaceutical or dietary composition comprising an extract of the bacteria Arthrobacter agilis, preferably rich in carotenoids.

Abstract: Convenient, inexpensive and portable effervescent tablets that the consumer can add to water to generate hydrogen-rich water just prior to drinking. The effervescent tablets include a base metal and an edible acid that, within about 5-10 minutes of mixing, generate a palatable aqueous solution having about 0.8 mM to about 3 mM hydrogen and a pH of 8-10.

Abstract: The present technology provides intravaginal devices designed to deliver lubricants to the vagina for a sustained period of time. The intravaginal devices include a first segment comprising an outer surface and a lumen containing a lubricant, wherein the first segment is configured to deliver the contents of the lumen to the outer surface, and the first segment comprises a polymer selected from the group consisting of a hydrophilic, semi-permeable elastomer and a hydrophobic elastomer. The lubricant may be an aqueous lubricant. The present technology further provides an intravaginal device including a solid first segment that includes a hydrophilic semi-permeable elastomer, an outer surface and an aqueous lubricant, wherein the first segment is configured to deliver the aqueous lubricant to the outer surface.

Abstract: The present invention relates to a homogeneous, stable, and palatable pharmaceutical solution comprising baclofen, sorbitol and naltrexone.

Abstract: Aspects of the present invention are directed to a nicotine lozenge for oral administration comprising: a nicotine active; at least one high viscosity, water soluble, synthetic or semi-synthetic, non-ionic polymer; and at least one low viscosity, water soluble, synthetic or semi-synthetic, non-ionic polymer. Lozenges of the present invention are more stable and less expensive than traditional lozenges.

Abstract: Human sperm is mobile only in a slightly acidic environment which is the normal state of the human vagina. Soap is a very basic material; introduction of a small amount of soap into the vagina before intercourse will raise the pH, a condition which causes the sperm to coagulate into a ball, that exits the vagina upon simply rinsing with water. The present invention is a composition of soap, water, and other natural materials that can be used as a vaginal suppository.

Abstract: An improved method for the manufacture of an oil-in-water emulsion involves circulation of emulsion components between a first container and a second container via a homogenizer and/or via a microfluidization device. Usefully, all of the emulsion components from the first container are emptied before being returned.

Abstract: Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.

Abstract: Provided herein are methods and compositions for the targeted delivery to myometrial tissue of one or more agents capable of regulating contractility of myometrial tissue, wherein the one or more agents are contained or encapsulated within a polymeric delivery vehicle conjugated with one or more molecules that recognizes and/or is capable of binding, directly or indirectly, to the oxytocin receptor.

Abstract: Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the invasiveness of the tumors, and inhibits tumor metastasis. The liposomes include cholesterol and chemically pure phospholipids that are essentially neutral and contain saturated fatty acids of between 16 and 18 carbon atoms, such as distearoylphosphatidyl choline, and can also include one or more pegylated phospholipids, such as DSPE-PEG.

Abstract: The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with siRNA, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo.

Abstract: Provided is an alkyl cellulose excellent in formability when added even in a small amount and not causing marked delay in disintegration; a solid preparation including it; and a method for producing the solid preparation. More specifically, provided is an alkyl cellulose for use in tableting, the alkyl cellulose having a specific surface area of from 0.5 to 10.0 m2/g as measured by BET method and a solid preparation including the alkyl cellulose. Also provided is a method for producing the alkyl cellulose, including the steps of: bringing pulp into contact with an alkali metal hydroxide solution to obtain alkali cellulose, reacting the alkali cellulose with an etherifying agent to obtain a first alkyl cellulose, pulverizing the first alkyl cellulose, and depolymerizing the pulverized first alkyl cellulose through hydrolysis with an acid catalyst or through oxidative decomposition with an oxidant to obtain a second alkyl cellulose.

Abstract: This invention relates to swallowable tablets containing at least 80% by weight of N-acetylcysteine (NAC) and at least one pharmaceutically acceptable excipient, in particular tablets in which the sulfurous odor is absent, characterized in that the said tablets are assembled using a granulate prepared by means of a process of dry granulating the active ingredient alone, with which the excipients are mixed before compression.

Abstract: An oral cavity patch comprising: a drug layer and an adhesive layer, wherein the drug layer comprises a drug-release-controlling agent consisting of at least one selected from the group consisting of a hydroxyalkyl alkyl cellulose, hydroxypropyl cellulose, a sodium carboxyalkyl cellulose, ethyl cellulose, hydrogenated castor oil, and a sucrose fatty acid ester.

Abstract: A stable composition with a benzimidazole derivative, such as Omeprazole, which does not contain a separating layer between the active compound and an enteric coating layer. Instead, the enteric coating layer is applied as a solution with a pH value of at least 6.5, and more preferably in a range of from about 7 to about 10, directly to the benzimidazole derivative substrate. This solution, with the optional addition of a plasticizer, can be directly coated onto the substrate without any necessity for an intermediate layer. Furthermore, in this pH range, the enteric coating is optionally applicable in an aqueous solution, thereby obviating the need for organic solvents for dissolving the enteric coating material. The resultant formulation maintains the stability of the benzimidazole derivative during storage and at the same time protects the product during passage through the acidic environment of the stomach.

Abstract: Improved oral dosage forms of methyl hydrogen fumarate and prodrugs thereof are disclosed. Methods of treating diseases such as multiple sclerosis and psoriasis using such dosage forms are also disclose.

Abstract: Disclosed are once-daily formulations containing tetracyclines, especially doxycycline. Such formulations are useful, for instance, for the treatment of collagenase destructive enzyme-dependent diseases, such as periodontal disease and acne, and acute and chronic inflammatory disease states, such as rosacea and arthritis.

Abstract: The present invention provides, among other things, nanoparticle compositions including a plurality of nanoparticles, each of which is comprised of a biodegradable or biocompatible polymer arranged in a nanoparticle structure defining an internal lumen and an external surface and one or more of a preparation of hydrophilic cellular components and a preparation of hydrophobic cellular components. In some embodiments, the preparation of hydrophilic cellular components is encapsulated within the internal lumen and the preparation of hydrophobic cellular components is associated with the external surface. Various methods of making and using disclosed nanoparticle compositions are also provided.

Abstract: Lipidated glycosaminoglycan particles, prepared by reacting a glycosaminoglycan with at least one lipid to cross-link the carboxylic acid groups in the glycosaminoglycan with a primary amine in the lipid, are used to encapsulate drugs for use in the treatment of pathological conditions in an animal.

Abstract: Intact bacterially derived minicells containing functional nucleic acids or plasmids encoding functional nucleic acids can reduce, in targeted mammalian cells, drug resistance, apoptosis resistance, and neoplasticity, respectively. Methodology that employs minicells to deliver functional nucleic acids, targeting the transcripts of proteins that contribute to drug resistance or apoptosis resistance, inter alia, can be combined with chemotherapy to increase the effectiveness of the chemotherapy.

Abstract: The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.

Abstract: The present invention relates to products and methods for treatment of narcotic dependence in a user. The invention more particularly relates to self-supporting dosage forms which provide an active agent for treating narcotic dependence while providing sufficient buccal adhesion of the dosage form.