Abstract: The present invention provides thermo-sensitive, mucoadhesive biopolymer formulations that enhance the penetration of therapeutics across the skin or mucosal surfaces. In a preferred embodiment, the biopolymer formulation comprises co-polymer of poloxamer 188 and propylene glycol, laurocapram and, optionally, one or more therapeutic agents. Also provided are uses of the biopolymer formulations for topical therapy of cancer including cervical cancer.

Abstract: A cationic graft-copolymer for a drug delivery system comprising a unit derived from a having a hydroxyl groups, namely, a cationic polysaccharide of the following formula (1) (C6H7O2(OH)3-a (OX)a)xH2O (1) and a unit derived from a polymerizable olefin compound of the following formula (2) (a, x, X, R4, R5, R6, and R7 are defined in claim 1-8); a process for preparing the same and a transfection reagent made therefrom.

Abstract: The present invention relates to a solid composition containing ivabradine or a pharmaceutically acceptable salt thereof. Further, the invention relates to a method for the preparation of such a composition as well as a pharmaceutical product comprising such a composition.

Abstract: The present invention provides a gel formulation comprising diclofenac sodium which has superior transdermal flux properties, which may be used for the topical treatment of pain, such as in osteoarthritis.

Abstract: The present invention provides a gel formulation comprising diclofenac sodium which has superior transdermal flux properties, which may be used for the topical treatment of pain, such as in osteoarthritis.

Abstract: A liquid composition of an insoluble medicament and a preparation method thereof are disclosed. The composition includes insoluble medicament, oil for injection, phospholipid, and solvent; the percentage by weight of each component is as follows: insoluble medicament 0.01-10%, oil for injection 0%-20%, phospholipid 10-80%, solvent 20-89%. The preparation method for the composition includes the following steps: dissolving an insoluble medicament into solvent or oil for injection or a mixture thereof firstly, and then adding other components, and mixing uniformly; or dissolving an insoluble medicament into a mixture of other components, and mixing uniformly; or dissolving an insoluble medicament into part of solvent firstly, and then adding into a mixed solvent of other components and the remaining solvent, and mixing uniformly.

Abstract: The present invention relates to a particular class of biodegradable linkers, ensuring transiently stable conjugation of building blocks and/or bioactive compounds into drug delivery systems (DDS), such as DDS based on polymeric micelles or hydrogels. In addition, the present invention relates to compounds, comprising said linkers, such compounds preferably being prodrugs. Further, the invention is directed to the use of said linkers, and especially said biodegradable linkers, in a drug delivery system. Moreover, the invention relates to controlled release system comprising a polymer matrix, capable of releasing an active ingredient, wherein the active ingredient is covalently linked to the polymer molecules of the polymer matrix through said linkers, as well as to a method of synthesizing these linkers and preparing such controlled release systems.

Abstract: The present application discloses an acid labile lipophilic molecular conjugate of cancer chemotherapeutic agents and methods for reducing or substantially eliminating the side effects of chemotherapy associated with the administration of a cancer chemotherapeutic agent to a patient in need thereof.

Abstract: The present invention includes compositions and methods for targeting the LOX-1 receptor on immune cells and uses for the anti-LOX-1 antibodies.

Abstract: Provided are a photosensitizer-metal nanoparticle complex and a composition for photodynamic therapy or diagnosis having the same. The complex includes a photosensitizer, a metal nanoparticle, and a backbone linking the photosensitizer with the metal nanoparticle. The backbone has a polypeptide substrate capable of being specifically degraded by a protease. When the complex is administered to a patient, fluorescence and production of reactive oxygen species from the conjugated photosensitizers are inhibited in normal tissues due to the resonance energy transfer between the photosensitizer and metal nanoparticles, but in tumor tissues, fluorescence and production of reactive oxygen species from the released photosensitizers are activated, thereby effectively destroying the tumor tissues. In addition, the selective fluorescence in the tumor tissues can further improve accuracy of tumor diagnosis using the protease-activatable photosensitizer-metal nanoparticle complex.

Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.

Abstract: A contrast agent having a contrast protein have contrast properties and at least one targeting moiety, wherein the at least one targeting moiety is operatively linked to or incorporated within the contrast protein. Methods for targeting contrast agents and for preparing such agents are included.

Abstract: The present invention relates to a method for determining the anti-tumor efficacy of monoclonal antibodies in pre-clinical rodent testings and the use of said method for the reduction of side testings.

Abstract: A polynucleotide encoding a biosensor polypeptide comprising a modified circularly-permuted thermostable luciferase and a linker linking the C-terminal portion of the thermostable luciferase to the N-terminal portion of the thermostable luciferase. The modified circularly-permuted thermostable luciferase is modified relative to a parental circularly-permuted thermostable luciferase. The linker contains a sensor region capable of interacting with a target molecule in a cell. The modified circularly-permuted thermostable luciferase has an enhanced response after interaction of the biosensor with the target molecule relative to the parental circularly-permuted thermostable luciferase in the presence of the target molecule. Alternatively, the modified circularly-permuted thermostable luciferase has an enhanced response after interaction of the biosensor with the target molecule relative to the modified circularly-permuted thermostable luciferase in the absence of the target molecule.

Abstract: Nanoparticles are used as a contrast agent for magnetic resonance imaging and computed tomography. Each of the nanoparticles includes a metal alloy core and a plurality of hydrophilic molecules covalently bound to the surface of the metal alloy core. Also disclosed is a method for using the contrast agent.

Abstract: This invention includes agents and compositions having MRI, PET, CT, X-ray, SPECT or optical signals, and methods for their use in the determination of a target. In some cases, a MRI, PET, CT, X-ray, SPECT, optical or other signal produced by the agent or composition can be affected by the presence of the target. Examples of targets that can be determined by this invention include, but are not limited to zinc, copper, iron ions and other biological targets. Example of application for imaging in vivo includes the function of pancreas and other organs.

Abstract: Methods and compositions utilizing ether and alkyl phospholipid ether analog compounds for treating cancer and imaging, monitoring, and detecting cancer stem cells in humans.

Abstract: The invention generally provides processes for the preparation of radioiodinated 3-fluoropropyl-nor-?-CIT. In particular, the process uses an arylsilane intermediate, thus avoiding the use of hexamethylditin, and reducing the number of steps previously required for the preparation of radioiodinated 3-fluoropropyl-nor-?-CIT from anhydroecgonine methyl ester. The invention also relates to the alkylation of a nortropane to the corresponding N-(3-fluoropropyl) analog using 3-fluoropropanal.

Abstract: A device and system is disclosed for sterilizing objects, commonly dental, medical, or veterinary instruments, by directing high velocity hot air into a container having pre-constructed plenums to direct, diffuse, and re-circulate the sterilizing agent uniformly throughout the chamber to effect sterilization of contained medical objects. More specifically, the invention employs high velocity hot dry air as the sterilizing agent, generating the heat and rapid airflow by means of a base unit. The high velocity heated air is forced into the medical instrument container where a removable air supply/return plenum directs the heated, rapidly flowing air uniformly throughout the container. During the sterilization process heated air temperature is maintained in the container by a continual re-circulating of exhaust air back to the base unit for re-heating and return to the container.

Abstract: An autoclavable bucketless cleaning system, including a vessel for storing fluid under pressure, a removably-connectable outlet regulator assembly for dispensing fluid from the vessel, a removably-connectable inlet regulator assembly for pressurizing the vessel, a removably-connectable outlet autoclave stem for installing in the outlet regulator assembly so that steam may pass through the outlet regulator assembly, and a removably-connectable inlet autoclave stem for installing in the inlet regulator assembly so that steam may pass through the inlet regulator assembly.

Abstract: Methods and systems for reduced temperature radiation sterilization of stents are disclosed.

Abstract: A system and method for sterilization of medical devices includes methods for reducing the variance in dose levels over the medical device by either varying the dose levels for each pass before a radiation source, such as an electron beam, or by increasing the number of passes before a radiation source.

Abstract: A sanitization cabinet for sanitizing items such as kitchen utensils using ultraviolet light type C (UVL-C). In some embodiments, the sanitization cabinet includes an enclosure having interior surfaces having mirror-type surfaces to increase the sanitizing efficiency relative to conventional UVL-C cabinets having like-power UVL-C light sources. Some embodiments include an article support having an article support region that contacts an article to be sanitized and is made of a material transparent to UVL-C. Transparent portions of an article support of the present disclosure may be additionally configured to direct UVL-C to contact regions and/or shadowed regions of the article. Other features, such as article stabilizing features, are provided to article supports of some embodiments. Methods of making an article support for a UVL-C based sanitization cabinet are also disclosed.

Abstract: A solution for disinfecting a screen of an item using ultraviolet radiation is provided. The solution can provide an electronic device including a screen utilized by a user of the electronic device. The screen can be an ultraviolet transparent screen that covers at least some of the internal portion of the electronic device and a set of ultraviolet radiation sources can be located adjacent to the transparent screen. The set of ultraviolet radiation sources can be configured to generate ultraviolet radiation directed towards an external surface of the ultraviolet transparent screen. The electronic device can further include a monitoring and control system, which can manage the ultraviolet radiation generation by monitoring a set of attributes relating to the external surface of the screen and controlling, based on the monitoring, ultraviolet radiation directed at the external surface of the screen.

Abstract: Exemplary methods and systems for killing or deactivating spores include applying a fluid to a surface containing a spore; and applying direct or indirect plasma to the surface for a period of time. In some embodiments, the fluid includes water. In some embodiments, the spore is Clostridium difficile and in some is Bacillus Anthracis. In some embodiments, the fluid is in the form of a mist and in some is in the form of a vapor. In some embodiments, peroxynitrite is created in the fluid during the method. Another exemplary embodiment of killing or deactivating a spore includes treating spores with direct plasma or an indirect plasma for a period of time and applying an antimicrobial to the spores. In some embodiments, the antimicrobial is an alcohol, a bleach or an alcohol-based sanitizer.

Abstract: An apparatus (1) for the sterilization of plastics material containers (10), and in particular of plastics material pre-forms (10), with a conveying device (2) which conveys the plastics material containers (10) along a pre-set conveying path, with at least one stressing device (4) which acts upon an external surface of the plastics material containers to be sterilized with a flowable medium. According to the invention the stressing device is arranged in such a way that it acts upon a pre-set area of the plastics material containers (10)—situated below an aperture of the plastics material pre-forms—with the sterilization medium.

Abstract: Provided herein is a method of reducing a microbial infection of a heparinized surface wherein heparin precipitation is reduced as compared to a control. In some embodiments a composition comprising ethanol and isopropanol is applied to the surface. In other embodiments, two or more ethanol compositions are applied and removed sequentially from the surface prior to contacting the surface with a biological fluid, tissue or vessel, wherein the composition in each successive administration comprises an increased amount of ethanol. Also provided is a method of reducing a microbial infection of a surface comprising applying a mucilage extract from an Opuntia ficus indica species to the surface.

Abstract: Medical devices, including medical adhesives, need to be sterile before application to a patient. A dry heat sterilization process can sterilize medical adhesives for patient application. The dry heat sterilization process can be validated for particular equipment arrangements and medical adhesives being utilized.

Abstract: A personal electronic device (PED) sanitization device comprises a compartment configured to receive a plurality of PEDs and one or more emitters configured to emit electro-optical (EO) radiation into the interior of the compartment. The compartment may comprise a support member configured to maintain the plurality of PEDs such that substantially an entire surface of each of the plurality of PEDs is exposed to EO radiation emitted by the one or more emitters.

Abstract: An emanator device for emanating an air treatment agent into the surrounding air comprises a housing (102) which contains a solid or liquid source of the air treatment agent, wherein the housing comprises a blister or capsule containing an air treatment agent (108) and a plurality of openings which are sufficiently small that they can be closed by a film or plug of water. For example the openings may be provided by a gauze or mesh (114). The openings do not inhibit the emanation of air treatment agent released from the blister, but when the emanator device is subject to wet conditions, as may happen in a dishwashing machine, the openings are blocked by a film or plug of water. The air treatment agent does not therefore enter the water, where it may have caused adverse effects, or simply have been wasted. Under dry conditions, however, emanation occurs normally.

Abstract: An emanation device for use with a replaceable refill of volatile liquid containing one or more active materials is described wherein the active material comprises at least one of: a fragrance; an insecticide; a fungicide; a pesticide; a sanitizing material; and/or a pharmaceutical; wherein the refill comprises a sealed reservoir containing said volatile liquid and a porous wick which extends from the interior of the reservoir to the exterior thereof, wherein the device comprises: an air pump; a fluid conduit in fluid communication with the air pump such that, in use, air pumped by the pump will flow through the fluid conduit; a nozzle located at the end of the fluid conduit remote from the air pump; a ejector constriction provided in the fluid conduit adjacent or substantially adjacent the nozzle; a liquid conduit provided adjacent the ejector constriction and in fluid communication with the fluid conduit at one end thereof, and open at the other end to receive liquid therein; refill securing means configure

Abstract: A contamination control system for ductless air conditioners is disclosed. The contamination control system may be formed from one or more decontamination lamps contained within a tubular housing that is hollow and includes an internal cavity extending from the first end to the second end with at least one longitudinally extending sight window positioned between first and second tubular end regions. The decontamination lamp may be positioned within the internal cavity in the tubular housing. The tubular housing may be held in place with a mounting system including at least one tubular housing receiver in which the tubular housing is secured. The tubular housing is slidably held within the mounting system such that the tubular housing is slidable longitudinally relative to the tubular housing receivers and is rotatable within the tubular housing receivers. The decontamination lamp may be activated with a photo activated sensor.

Abstract: A tampon applicator that is water-sensitive (e.g., water-soluble, water-dispersible, etc.) in that it loses its integrity over time in the presence of water is provided. The tampon applicator can be discreetly disposed of in a toilet without the risk of clogging sewer pipes. The tampon applicator includes a molded thermoplastic composition containing a cellulose derivative, a synthetic water-soluble polymer, and a plasticizer. The desired water-sensitive characteristics of the tampon applicator may be achieved in the present invention by selectively controlling a variety of aspects of the thermoplastic composition from which the applicator is formed, such as the nature of the components employed, the relative amount of each component, the manner in which the composition is formed, and so forth.

Abstract: The present invention addresses the problem of providing a novel absorbent that comprises a water-absorbing cellulose-based fiber and a thermoplastic resin fiber, said thermoplastic resin fiber containing as a monomer component an unsaturated carboxylic acid or an unsaturated carboxylic acid anhydride, and has both a sufficient strength and a sufficient absorption property. The absorbent comprises a water-absorbing cellulose-based fiber and a thermoplastic resin fiber, said thermoplastic resin fiber containing as a monomer component an unsaturated carboxylic acid or an unsaturated carboxylic acid anhydride, wherein the mass ratio (the content of the water-absorbing cellulose-based fiber: the content of the thermoplastic resin fiber) is controlled to 90:10 to 50:50 and the density of the absorbent is controlled to 0.06 to 0.14 g/cm3.

Abstract: In order to provide an absorbent, which contains no wood pulp and wood pulp and has improved liquid absorbability and improved liquid retention ability, and an absorptive article provided with the absorbent, no wood pulp having a settling time in water of 2-5 sec is used in an absorbent that contains no wood pulp and wood pulp.

Abstract: A biocompatible tissue-bonding adhesive composition having a polyol of functionality N. The polyol being terminated has at least one polyisocyanate in solution with at least (N?1)% of the solution having free polyisocyanate. N may be in the range 1.5-8. The polyol may be a branched polypropylene/polyethylene oxide copolymer.

Abstract: A biogel, and kits, agents, and methods for formation of the biogel are described. The biogel can be used for a variety of applications, including haemostasis, wound sealing, tissue engineering or localized drug delivery.

Abstract: A surgical implant component comprising an implant component body manufactured from a Co-based substrate alloy comprising Co, Cr, Mo, Si, and C, and a coating on a bone-ingrowth surface of the component body manufactured from a Co-based coating alloy comprising Co, Cr, Mo, Si, C and B. The coating is a network of fused particles of the Co-based coating alloy with spherical particles, irregular aspherical particles, and between about 35 and about 70 volume % porosity. A method of manufacturing the foregoing surgical implant component.

Abstract: The present invention relates to a modular supramolecular bioresorbable or biomedical material comprising (i) a polymer comprising at least two 4H-units and (ii) a biologically active compound. Optionally, the supramolecular bioresorbable or biomedical material comprises a bioresorbable or biomedical polymer as third component to tune its properties (mechanical and bioresorption properties). The supramolecular bioresorbable or biomedical material is especially suitable for biomedical applications such as controlled release of drugs, materials for tissue-engineering, materials for the manufacture of a prosthesis or an implant, medical imaging technologies.

Abstract: Compositions and methods for repairing a ruptured connective tissue are disclosed. The composition may include a first biocompatible material to provide a scaffold for connective tissue cell growth and tissue repair. This first biocompatible material may withstand a tensile load of up to 250 N. The composition may also include a second biocompatible material including at least one bioactive agent that can stimulate connective tissue cell growth and tissue repair. The method may include positioning a first end of the first biocompatible material adjacent a first end of a ruptured connective tissue, positioning a second end of the first biocompatible material adjacent a second end of the ruptured connective tissue, and anchoring the first biocompatible material to the first and second tendon ends. The method may alternatively comprise or further include positioning a second biocompatible material between the first and second ends of the ruptured connective tissue.

Abstract: A substrate has an electron donating surface, and metal particles on its surface, the metal particles including palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of the metal particles is from about 0.001 to about 8 ?g/cm2.

Abstract: The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process. The pulsatile acidification wave process includes subjecting bone to two or more rapid pulse/drain cycles in which one or more demineralizing acids is rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel. The continuous acid demineralization process includes subjecting bone to a continuous exchange of demineralizing acid solution in which the demineralizing acid solution is recirculated from the container holding the bone through an ion exchange media.

Abstract: This invention relates to a biomaterial comprising an injectable bioresorbable polysaccharide composition wherein the polysaccharide may be succinochitosan glutamate. This invention also relates to a biomaterial comprising an injectable bioresorbable polysaccharide composition in which resorbable particles may be in suspension, the said particles comprising or consisting essentially of chitin and/or chitosan, which may be free of any additional formulation modifying agents, and a process for manufacturing the same. This invention also relates to a medical device including said biomaterial and to a method of repair or treatment including the filling of cavities in the human face or body.

Abstract: Embolization, as well as related particles, compositions, and methods, are disclosed.

Abstract: A polymer of fluorinated monomers and hydrocarbon monomers is provided. It is also provided a polymer blend that contains a polymer-formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer. The polymer or polymer blend described herein and optionally a bioactive agent can form an implantable device such as a stent or a coating on an implantable device such as a drug-delivery stent, which can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Abstract: The present invention relates to a combination of agents, including an anti-proliferative agent, an anti-inflammatory agent, an anti-growth factor, and an extracellular matrix (ECM) molecule coated on a stent to prevent acute and subacute thrombosis, enhance endothelial in-growth, and prevent neointimal hyperplasia, and/or suppress neovascularization, and thereby reduce restenosis rates for drug eluting stents. The present invention also relates to methods of using such multiple drug eluting stents for the treatment of heart disease and other vascular conditions.

Abstract: The evacuation system employs a piston to deliver fluid for irrigating and aspirating a body cavity, such as a bladder. A pivotal screen is disposed across the flow path of the fluid to move out of the fluid flow path during irrigation of the bladder and to move back into the flow path during aspiration of the bladder. The screen screens out particulate matter from the return flow for depositing into the container of the system.

Abstract: An apparatus including: a vacuum container configured to provide and substantially maintain a built-in vacuum pressure; a contact member configured to contact and substantially enclose a surface area; a vacuum device configured to couple the built-in vacuum pressure to the surface area thereby applying a suction force over the surface area; and a conduit coupled to the vacuum container; wherein the vacuum container is also configured to retain a substance collected from adjacent the surface area, wherein the conduit is configured to direct the substance to the vacuum container, and to maintain substantially the same level of vacuum pressure as the vacuum container, wherein the vacuum container comprises a collapsible container, and wherein the collapsible container comprises a spring member configured to maintain a tension in a wall of the vacuum container.

Abstract: In a rotor for a fluid pump which is made radially compressible and expandable and has a hub (4) and at least one conveying element (10, 11, 19, 20) which has a plurality of struts (12, 13, 14, 15, 16, 21, 22, 27, 28) and at least one membrane (18) which can be spanned between them, provision is made for a design in accordance with the invention which is as simple and inexpensive as possible that at least one first group of struts is pivotable in a pivot plane, starting from a common base, and can thus be spanned open in the manner of a fan, wherein the conveying element lies along the hub and contacts it over its full length in the expanded state to avoid a pressure loss at the margin of the conveying element between it and the hub and thus to realize an optimum efficiency.

Abstract: A hemodynamic flow assist device includes a miniature pump, a basket-like cage enclosing and supporting the pump, and a motor to drive the pump. The device is implanted and retrieved in a minimally invasive manner via percutaneous access to a patient's artery. The device has a first, collapsed configuration to assist in implantation and a second, expanded configuration once deployed and active. The device is deployed within a patient's aorta and is secured in place via a self-expanding cage which engages the inner wall of the aorta. The device includes a helical screw pump with self-expanding blades. Also included is a retrieval device to remove the hemodynamic flow assist device once it is no longer needed by the patient. Also included is an arterial closure device to close the artery access point after implantation and removal of the hemodynamic flow assist device.