Abstract: A medication compliance package includes an outer carrier of card defining a rear panel into which the pockets of a blister sheet are attached and covered by a foil layer. A front panel folds over the rear panel to cover its front face and the pockets. The front panel has a slot shaped opening along the mutual side edge with the rear panel to allow fingers of the hand of the user to extend through the opening, with the front and rear panels in the open position, from the rear face of the front panel to reach around the mutual side edge to the rear face of the rear panel. This simplifies the act of popping the medications out of the blister since the fingers engage the rear of the rear panel and the thumb can be used to apply pressure to the pockets.

Abstract: A protected blister package assembled by a pharmacist for a patient has the correctness of its assembly confirmed by checking the correct correlation of three binary codes respectively appearing on three components of the package. The first component comprises a blister sheet loaded with the prescribed medication doses; the second component comprises a backing sheet sealing the medication doses in the cavities of the package blisters; and the third component comprises a protective card to be folded around the blister package after it has been attached to the card. Prior to assembly of the blister package two of the binary codes are printed on the backing sheet and the third binary code is printed on the card. During assembly of the package a portion of the backing sheet bearing one of its two codes is transferred to a predetermined position on the blister sheet. After assembly of the protected blister package the three binary codes are scanned to confirm that the package has been correctly assembled.

Abstract: An adaptor intended to be mounted on a distal tip of a drug delivery device is provided. The distal tip defines an axial passageway for transfer of a product contained in the drug delivery device. The adaptor has a longitudinal axis A aligned on the axial passageway. The adaptor includes: a connection member for connecting the adaptor to a connector; an inner ring releasably engageable on the distal tip; and a compression component separate from the inner ring and configured to be unreleasably snap-fitted onto the inner ring engaged on the distal tip by proximal movement of the compression component with respect to the inner ring. The compression component is configured to exert a centripetal pressure on the inner ring so as to prevent axial movement of the inner ring with respect to the distal tip.

Abstract: The invention relates to a device for dosing particles, especially medicaments in the form of microspheres, comprising: a store for the particles, comprising an opening and means for closing said opening; syringe-type dosing means comprising a tube and a piston which is slidably mounted in the tube, said means being detachably fixed to the store, at the opening; and means for transferring particles between the opening of the store and the dosing means, which are an integral part of the store, the dosing means being independent from the transfer means. The invention is characterized in that the transfer means can be actuated by a user in order to allow the particles to leave the store.

Abstract: A kiosk according to an embodiment of the present invention includes a housing; a touch screen configured to receive input information from a user; a label printer configured to print output information from the kiosk; a pill drop opening; a pill chute; a drive tube having entry and exit openings, wherein the drive tube has an axis extending through a longitudinal axial centerline thereof, and has an inside surface comprising a helical flute, wherein the entry opening is in communication with the pill chute, and wherein the exit opening is higher than the entry opening such that the axial centerline of the drive tube is inclined; a motor configured to rotate the drive tube to separate and convey pills received through the pill drop opening and the pill chute; and an optical counter configured to count the pills as the pills fall from the exit opening of the drive tube.

Abstract: A self-paced, ergonomic feeding bottle with a substantially-straight back sidewall and an “S”-shaped curved front sidewall; where the curved front sidewall comprises two sections: (1) a convex chest section near the top, and (2) a concave handle section near the bottom, comprising a concave crook and a thin waist. The top-heavy bottle has a single plane of symmetry located between the right and left hand sides of the bottle. An anti-vacuum valve can be inserted into a vent hole. Side positioning markers can be used to achieve zero hydrostatic pressure during use. Anti-roll pads are part of the front sidewall.

Abstract: A dual material Y-connector for use in connection with medical tubing systems and the like includes an inner core made of a first material such as a rigid plastic material and an over-layer made of a second material such as a pliable thermoplastic elastomer. The Y-connector comprises a primary arm, a secondary arm and a convergence arm all in fluid communication with one another and may include a tubing segment bonded to the Y-connector convergence arm. The first material can be a transparent copolyester and the second material can be a translucent thermoplastic elastomer. Threaded caps having a multi-indentation configuration can be tethered to one or more arms and be configured to seal one or more Y-connector ports.

Abstract: Ostomy tubes, particularly gastrostomy tubes, with improved retention means are provided. More specifically, retention structures, such as bolsters, for gastrostomy tubes are provided, configured to removably assemble to one end of a gastrostomy tube to facilitate replacement and removal of the tube. The retention structures provided herein may comprise one or more removably assembled retention elements. Further provided are gastrostomy tubes comprising such retention structures, and methods for percutaneous endoscopic gastrostomy utilizing same.

Abstract: There is provided a computer-implemented method for calculating a gastric emptying rate from a stomach lumen into a small intestine of a patient, comprising: using at least one processor for executing the following during an enteral tube feeding of a stomach of the patient by a feeding mechanism: analyzing outputs of at least one stomach sensor located within the stomach for detecting a stop feeding condition; pausing the enteral tube feeding in response to a detection of the stop feeding condition; after a predefined period of time, restarting the enteral tube feeding until the stop condition is redetected by an analysis of said outputs; calculating a gastric emptying rate based on an amount of feeding content delivered during a period between the restarting and the redetection; and instructing the feeding mechanism to adapt a feeding rate of the enteral tube feeding according to the gastric emptying rate.

Abstract: A dental cement hardened by a cement reaction involving the specific polymerizable polyacidic polymer and optionally additional crosslinkable groups, has reduced shrinkage and improved mechanical properties, in particular with regard to flexural strength and fracture toughness. Moreover, the specific polymerizable polyacidic polymer of the present invention contains a high number of acidic groups which is not reduced by the presence of polymerizable moieties, whereby water solubility of the uncured polymer is not impaired by the presence of the polymerizable moieties.

Abstract: An economical soap bar which includes a soap bar body with a hollow interior and an insert occupying the hollow interior, preferably with projecting fingers that penetrate into the soap bar body. The projecting fingers or follicles are designed to penetrate into the body of the soap and provide a massaging sensation to the body by being formed of flexible, hair-like or follicles that are very flexible, or by providing the follicles as combination of flexible fingers, some of which have a rigidity greater than other projecting fingers that are more flexible.

Abstract: The present invention provides a colorful gel, comprising following components by weight percentage: 20.0% to 25.0% by weight of glycerin, 20.0% to 25.0% by weight of propylene glycol, 1.0% by weight of sea algae extract, 0.05% by weight of disodium EDTA, 0.06% by weight of allantoin, 0.05% by weight of sodium hyaluronate, 20.0% to 30.0% by weight of cyclopentasiloxane, 5.0 to 10.0% by weight of dimethicone, 0.5 to 1.0% by weight of sodium acrylate/sodium acryloyldimethyl taurate copolymer, 0.25 to 0.5% by weight of isohexadecane, 0.2% to 0.4% by weight of polysorbate-80, 1.5% by weight of soluble collagen, 0.5% by weight of caprylyl glycol, and water as the rest. The present invention also provides a preparation method of the colorful gel. The colorful gel of the present invention has excellent moisturizing performance, and it can keep moisturizing skin, which is safe and healthy.

Abstract: A packaged product is provided that includes a container with a consumer medium and a propellant medium stored therein. The container is a non-barrier type aerosol container. The propellant medium includes a hydrocarbon agent. In some embodiments, the consumer medium is water-based and at least substantially free of solvents. In some embodiments, the propellant medium additionally includes an organoflourine agent and/or carbon dioxide.

Abstract: Provided is an eyelash ornament cosmetic comprising at least a polymer emulsion and an extender wherein an average particle diameter of the extender is 1 ?m or less, wherein droplets applied on the tips of eyelashes are dried and turned into fine spherical resin balls, and the tips of the eyelashes are ornamented to make it possible to provide the eyes with brilliantness and loveliness.

Abstract: The present invention is directed to a granulated composition comprising a salt encapsulated by a composition that comprises at least one wax.

Abstract: The present invention relates to a cosmetic composition comprising: (i) at least one oxide of an alkaline earth metal (ii) at least one metal soap, preferably a metal salt of C10-30 fatty acid, and (iii) an aqueous phase. The cosmetic composition according to the present invention can provide a long-wear effect, especially a long-wear makeup effect.

Abstract: Suggested is a composition comprising (a) at least one lactate ester and (b1) at least one second compound selected from the group encompassing benzaldehyde derivatives, aromatic aldehydes and aromatic acids.

Abstract: The present invention relates to a process for dyeing human keratin fibres, in which use is made of one or more metal catalysts and a composition (A) comprising: (a) at least 10% by weight of one or more fatty substances, (b) one or more oxidation bases of formula (I) or (II), the addition salts thereof, solvates thereof and mixtures thereof: Formula (I), Formula (II) (c) one or more chemical oxidizing agents other than atmospheric oxygen. The invention also relates to a multi-compartment device and to a composition comprising all of the above-mentioned ingredients.

Abstract: The present invention relates to a composition comprising one or more quaternary ester ammonium compounds (a), one or more amidoamine compounds (b), wherein the weight ratio between the one or more quaternary ester ammonium compounds (a) and the one or more amidoamine compounds (b) is within a range of 1:5 to 5:1, and one or more fatty alcohols (c). The present invention also relates to a composition that is solid at room temperature, to a hair conditioner composition and to a method to prepare the hair conditioner composition by dispersing the solid composition in water at moderate temperatures.

Abstract: The invention relates to N-alkyl-N-acylglucamines of formula (I), which exhibit in hair-washing agents comprising an aqueous surfactant system with at least one anionic surfactant, a hair-conditioning effect, wherein, in formula (I), Ra is a linear or branched, saturated or unsaturated C5-C21 alkyl radical and Rb represents a C1-C4 alkyl radical, and wherein the N-alkyl-N-acylglucamines (I) contain at least 8 wt. %, based on the total amount of N-alkyl-N-acylglucamines (I), of compounds with a saturated C16-, C18- or a mono- or polyunsaturated C18 fatty acid radical Ra—CO—.

Abstract: Fragrances that provide a scent of freshness tend to be volatile and are therefore not very economical when used in typical applications such as washing or cleaning processes, so they have to be used in relatively large quantities to be able to produce adequate effects. The disclosed photolabile pro-fragrances provide a much longer-lasting sense of fragrance, in particular with a scent of freshness, when used in typical applications, thus allowing said fragrances to be used economically.

Abstract: The invention provides skin compositions containing a mixture of milled particles having different sizes less than 50 microns in diameter of vitamins in a biocompatible carrier.

Abstract: The present invention relates to a topical composition comprising a hydrophilic benzimidazole type UVB filter, an organopolysiloxane functionalized with at least one UV-light absorbing group, and highly porous silica and/or highly porous crosslinked polymethylmethacrylate beads having a particle size Dv0 of greater 0.3 ?m, a Dv 100 of less than 35 ?m, a Dv50 selected in the range of 9 to 15 ?m and an oil absorption capacity selected in the range of 1.2-2.5 cc/g. Furthermore the invention relates to the use of such beads to ameliorate the short and long-term sensory properties of a topical composition comprising a hydrophilic benzimidazole type UVB filter and an organopolysiloxane functionalized with at least one UV-light absorbing group.

Abstract: The invention thus relates to the cosmetic use of a siliceous material that may be obtained by hydrolysis and condensation, in the presence of water, of at least one tetraalkoxysilane of formula (I) below: Si(OR2)4 (I) and of an alkyltrialkoxysilane of formula (II) below: R1Si(OR2)3 (H) in which: R1 denotes a C7 to C20 alkyl group, optionally interrupted in its chain with an O or S atom or with an NH group or a carbonyl group (CO), R2 denotes a C1-C4 alkyl group. Preferentially, the siliceous material is present in a composition comprising a cosmetically acceptable medium. The invention also relates to a cosmetic process for treating human body odour, in particular underarm odour and optionally human perspiration, which consists in applying to human keratin materials the said siliceous material or a composition containing the same in a cosmetically acceptable medium.

Abstract: A bubble type waterless shampoo composition. 0.1 to 5 wt % of potassium cocoyl hydrolyzed collagen and 0.01 to 2 wt % of palmitoyl oligopeptide as natural surfactants. 0.1 to 7 wt % of cocamidopropyl betaine as an amphoteric ion. 0.01 to 0.8 wt % of a citric acid as an organic acid. 0.1 to 4 wt % of sodium carbonate as inorganic salt. 0.01 to 0.5 wt % of origanum vulgare leaf oil. 0.01 to 0.6 wt % of a gallic acid. 0.01 to 3 wt % of glycerin. The rest of aqua water having a function of a solvent made by refining tap water through distilling or ion-exchange resin ion.

Abstract: Provided is a hair care composition for providing improved root lift including at least 0.1% dehydroxanthan gum, from about 0.2% to about 1% of a panthenol compound, from about 0.1% to about 10% of a rheology modifier, and a carrier.

Abstract: A method of achieving improved hair feel. The method comprises applying to hair a composition comprising: (a) a specific cationic guar polymer; (b) a specific cationic copolymer; (c) an anti-dandruff active; (d) a cosmetically acceptable carrier; (e) a surfactant; wherein the weight ratio of (a):(b) is from about 1000:1 to about 3.5:1; and wherein the sum of (a)+(b) is an amount of from about 0.0001% to about 0.7%, by total weight of the composition. The composition forms coacervate particles upon dilution of the composition with water and the coacervate particles have a squeeze flow viscosity of from about 1 cP to about 100 cP. The percentage of coacervate particles with a floc size of greater than about 20 micron is from about 1% to about 60% and the on-scalp deposition of the anti-dandruff active is at least about 1 microgram/cm2.

Abstract: A skin engaging member suitable for use in a hair removal device, said skin engaging member comprising ethyl vinyl acetate having a low level of vinyl acetate and a water soluble polymer.

Abstract: The present invention provides a variable color transparent lip balm, consisting of following components by weight percent: 4.0 to 5.0% by weight of dibutyl lauroyl glutamide, 2.0 to 3.0% by weight of polyamide-3, 15.0 to 20.0% by weight of bis-stearyl ethylenediamine/neopentyl glycol/stearyl hydrogenated dimer dilinoleate copolymer, 46.65 to 49.60% by weight of C12-15 alkyl benzoate, 1.0 to 3.0% by weight of heptyl undecylenate, 9.0 to 11.0% by weight of C10-30 cholesterol/lanosterol esters, 10.0 to 15.0% by weight of hydrogenated C6-20 polyolefin, 1.5 to 2.5% by weight of dextrin isostearate, 0.05 to 0.1% by weight of eosin yellowish and 0 to 0.8% by weight of excipient. The transparent lip balm of the present invention has good transparency, and excellent variable color effect.

Abstract: Polymeric compositions containing additives having properties of emission and/or absorption of radiation in the long infrared region, and articles shaped therefrom are produced, including yarns and textile articles such as fabrics or knits; such additives include organic additives or inorganic fillers which have a capacity for absorption/emission of radiation in the infrared region, in a wavelength range of from 2 ?m to 20 ?m, and also a polymeric substrate, with the proviso that the inorganic fillers may be selected from among oxides, sulfates, carbonates, phosphates and silicates, and such inorganic fillers having an average particle size of less than 2 ?m.

Abstract: The invention relates to water-free compositions, having: at least one oil, and a combination of thickeners, including: a) at least one silicone elastomer, b) at least one straight-chained or branched, saturated or unsaturated alcohol having more than 18 carbon atoms, and c) at least one clay mineral mixture modified with quaternary ammonium compounds. The water-free compositions are suitable in particular as soft solid preparations for use on the human skin. In particular, the compositions are suitable as a soft solid antiperspirant composition.

Abstract: Provided are body corrective cosmetic formulations and methods of use thereof.

Abstract: The present invention relates to a composition for treating keratin fibres, comprising at least an aqueous dispersion of hybrid hydrophobic film-forming acrylic polymer particles, at least one linear block silicone copolymer and at least one amino acid or amino acid derivative.

Abstract: Cosmetic compositions include, based in each case on the total weight of the composition, 0 to 3% by weight, in particular 0 to 2% by weight, of free water, one or more liquid oils in a total amount of from 40 to 80% by weight, in particular from 50 to 75% by weight, in particular from 60 to 70% by weight, at least one wax, solid dispersed in particulate form. The cosmetic composition has a viscosity of from 300 000 to 800 000 mPas, in particular from 400 000 to 600 000 mPas, has a density of from 0.95 to 1.10 g/cm3 at 20° C., has a light texture and can be spread easily on a substrate. If the substrate is skin, a pleasant skin feel is conveyed.

Abstract: The present disclosure encompasses formulations, and methods of manufacture and use thereof, for topical application to and conditioning of human skin. The formulations disclosed comprise an effective amount of at least one steroidal agent, plant extract, viscosity-adjusting agent, anti-oxidant. In particular, the formulations comprise an effective amount micronized progesterone and are used for topical application to the skin of men.

Abstract: The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to an eye for the treatment of an ocular disorder, for example, age-related macular degeneration.

Abstract: The present disclosure provides a rapidly disintegrating orally administrable powder. The powder may include an active ingredient such as a dietary supplement. Methods of using the same are also provided herein.

Abstract: An oral methylphenidate extended release tablet is described, which can be scored and still retain its extended release profile. The tablet contains a combination of an uncoated methylphenidate-ion exchange resin complex, a barrier coated methylphenidate-ion exchange resin complex-matrix, and an uncomplexed methylphenidate active component. Following administration of a single dose of the extended release methylphenidate chewable tablet, a therapeutically effective amount of methylphenidate is reached in less than about 20 minutes and the composition provides a twelve-hour extended release profile.

Abstract: The present invention is antibiotic compositions, ventilator-based systems and methods relating to ventilator-associated pneumonia (VAP) and ventilator-associated tracheal (VAT) bronchitis. Antibiotic combinations of fosfomycin and an aminoglycoside, preferably amikacin, are administered via an inline nebulizer within the airway of the ventilator. Humidified conditions create an improved aerosol mist to treat VAP and VAT.

Abstract: Essentially non-aqueous liquid pharmaceutical formulations are formed by mixing at least one pharmaceutically active ingredient and at least one other compound capable of interacting with the active pharmaceutical ingredient through non-covalent interactions to form a low-temperature transition mixture. The stable liquid formulations are readily obtained, even with drugs that are poorly soluble and/or unstable in water.

Abstract: Disclosed herein are methods of treating pulmonary disorders comprising administering to the patient an effective dose of a nebulized liposomal amikacin formulation for at least one treatment cycle, wherein: the treatment cycle comprises an administration period of 15 to 75 days, followed by an off period of 15 to 75 days; and the effective dose comprises 100 to 2500 mg of amikacin daily during the administration period.

Abstract: The invention relates to a granulate composition comprising 90-99.95% w/w of Imatinib mesylate, 0.05-0.2% w/w of binder and 0-8% w/w of disintegrant, wherein the granulate composition is prepared using binder in isopropyl alcohol solvent. The invention also relates to pharmaceutical compositions comprising Imatinib mesylate, with high polymorphic stability and processes for preparation thereof. Said granulate composition comprising 90-99.95% w/w of Imatinib mesylate and their pharmaceutical compositions derived may be useful in the treatment of cancer.

Abstract: The present invention relates to preparation of biodegradable microparticles formed from polylactide-polyglycolide copolymers (PLGA) polymer and how to achieve sigmoidal release of active pharmaceutical compound from the microparticles. In particular, the present invention relates to emulsification of an inner/oil phase to an outer/water phase followed by quenching and a single drying step for the preparation of microparticles having a preferred release profile of preferably basic/nucleophilic compounds such as risperidone. Alternatively the present invention is also suitable for hydrophobic compounds that have poor water-solubility and a high drug loading of >20% w/w is required. The release profile can be controlled by adjusting the degree of saturation of the outer/water phase with the organic solvent used in the inner/oil phase, the polymer concentration of the inner/oil phase and the temperature at the quenching step.

Abstract: The present invention provides long-term stable formulations of a lyophilized therapeutic peptibody and methods for making a lyophilized composition comprising a therapeutic peptibody.

Abstract: A method of preparing a lyophilized powder for injection, including: (1) weighing and mixing aloe powder and Panax pseudo-ginseng powder to yield an active pharmaceutical ingredient, and mixing the active pharmaceutical ingredient and distilled water to yield a mixed aqueous solution; (2) stiffing the mixed aqueous solution to enable the aloe power and the Panax pseudo-ginseng powder to be completely dissolved, and then allowing the mixed aqueous solution to stand; (3) collecting, filtering, and clarifying a supernate obtained in (2); (4) adding hydrochloric acid to a filtrate obtained in (3) to adjust the pH value of the filtrate, heating and sterilizing the filtrate, and then naturally cooling the filtrate, to yield a cooled liquid; (5) adding hydrochloric acid to the cooled liquid to adjust the pH value of the cooled liquid, filtering the cooled liquid and collecting a pharmaceutical solution; and (6) packaging and lyophilizing the pharmaceutical solution.

Abstract: An oral dexmethylphenidate extended release tablet is described, which can be scored and still retain its extended release profile. The tablet contains a combination of an uncoated dexmethylphenidate-ion exchange resin complex, a barrier coated dexmethylphenidate-ion exchange resin complex-matrix, and an uncomplexed dexmethylphenidate active component. Following administration of a single dose of the extended release dexmethylphenidate chewable tablet, a therapeutically effective amount of dexmethylphenidate is reached in less than about 20 minutes and the composition provides a twelve-hour extended release profile.

Abstract: The present invention relates to pharmaceutical compositions comprising a thyroid hormone drug. The invention also relates to processes for the preparation of such compositions.

Abstract: The present invention provides an extended-release capsule dosage form of metoprolol succinate in the form of coated discrete units and processes for their preparation.

Abstract: A hybrid silica bead having a millimeter scaled-size is adapted for the entrapment of a component or a bioactive substance. The bead is formed of a porous core including a hybrid alginate-silica and an external porous layer having silica and a silica concentrator. A one-pot process prepares hybrid beads for use of the beads for the entrapment of a component or a bioactive substance.

Abstract: Disclosed in certain embodiments is a solid oral dosage form comprising: (a) an inert tamper resistant core; and (b) a coating surrounding the core, the coating comprising an active agent.