Abstract: A method and apparatus for determining physiological data related to an animal, such as kidney diagnostics data, is provided. The method includes injecting a mixture of a first and a second molecule into an animal (e.g., a human patient), determining a molecular ratio of the molecules, and determining the physiological data based on the molecular ratio. The apparatus includes a number of finger receiving apertures, a light generation circuit, a light detection circuit, a pulse counting circuit, and a user interface.

Abstract: Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processes using a variety of imaging techniques are provided. The functionalized second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystalline materials that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy, and are provided with functional surface modifications that allow for targeted imaging of a variety of biological and non-biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.

Abstract: The present invention relates to a method for preparing a pharmaceutical formulation of lanthanide chelate in powder form, wherein the powder constitutes a mol/mol excess of free chelate of between 0.002 and 0.4%.

Abstract: The disclosure provides, in part, compositions and methods for producing emulsions. In certain embodiments, emulsions of the disclosure can be used for the detection of inflammation and cell tracking using MRI. The disclosure provides, in part, methods for labeling, detecting and quantifying cell members, in vivo. In certain embodiments, emulsions can be used as an artificial blood substitute.

Abstract: The present invention relates to a method of preparing biocompatible iron oxide nanoparticles by coating iron oxide nanoparticles having improved magnetism via annealing treatment using salt particles with a hydrophilic material and to a magnetic resonance imaging (MRI) contrast agent including the iron oxide nanoparticles prepared thereby. Among hydrophilic materials, carboxymethyl dextran (CM-dextran) is the most efficient in terms of stabilizing the annealed iron oxide nanoparticles and exhibiting contrast effects.

Abstract: The present invention is directed to novel non-invasive diagnostic tools to diagnose numerous infectious disease states or conditions. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to therapeutic treatments and other interventions or therapies used in the treatment of these disease states or conditions. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. Pharmaceutical compositions are also described.

Abstract: The present invention relates to the field of perfumery. It relates more particularly to a gel device which allows for an effective and prolonged evaporation of an active volatile ingredient. The gel device of the present invention comprises an active volatile and a gelling agent formed of carrageenan together with dibutyl lauroyl glutamide and/or dibutyl ethylhexanoyl glutamide, and a polyol.

Abstract: A balloon valve assembly for cooperating with a balloon includes a neck fitting to extend beyond a neck of the balloon, a collar portion to accept the balloon and the neck fitting. A change of pressure from the balloon urges the balloon and the collar portion together. The valve assembly is adapted to secure accessories that affect the five senses of sight, hearing, smell, taste and touch.

Abstract: Wearable devices for dispensing insect repellents, fragrances, and/or other chemicals along the outside of the clothing of a human are disclosed. They are of the type that are clipped onto a belt or the like, and use a powered fan to dispense active. They are configured with outlet arrangements to minimize power use while still achieving acceptable air flow rates. These changes permit use of smaller power supplies and more compact arrangements for power supply (e.g., battery) positioning. This in turn permits a much more compact and lightweight construction to achieve the desired results.

Abstract: Fragrance systems are provided that can be used in conjunction with heating, ventilation, and air-conditioning systems. The fragrance systems can inject a fragrance into an airstream that is supplied to a space such as a room of a building or a vehicle cabin. In some embodiments, the speed a fan of the fragrance system can be automatically modulated in a pre-determined relationship to the speed of a fan of the HVAC system. Accordingly, a desired level of fragrance can be automatically maintained as desired within the airstream that is supplied to the space, even when the HVAC fan speed or other conditions fluctuate.

Abstract: Wearable devices for dispensing insect repellents, fragrances, and/or other chemicals along the outside of the clothing of a human are disclosed. They are of the type that are clipped onto a belt or the like, and use a powered fan to dispense active. They are configured with a first timer to account for a passive release rate of the active and a second timer to account for an active release rate of the active. The first time and second timer are in communication with a useful life indicator to provide a signal to a user of the device to indicate when the substrate in the device for containing the active should be replaced.

Abstract: Scent dispenser arrangement for dispersing fragrance into a HVAC system includes a flow sensor and a scent disperser assembly having a control module connected to the flow sensor and a canister for emitting a spray which is actuated by the control module. The flow sensor operates in response to air flow and creates an air flow dependent electrical signal transmitted to activate the control module of the spray disperser assembly. The scent disperser and flow sensor are arranged to allow the spray to be disbursed in selective locations in the HVAC system. An embodiment involves two scent disperser assemblies electrically connected in series which operate successively when the liquid in one disperser assembly is depleted or when one disperser assembly dispersers a predetermined number of sprays.

Abstract: Hemostatic devices for promoting blood clotting can include a substrate (e.g., gauze, textile, sponge, sponge matrix, one or more fibers, etc.), a hemostatic material disposed thereon such as kaolin clay, and a binder material such as crosslinked calcium alginate with a high guluronate monomer molar percentage disposed on the substrate to substantially retain the hemostatic material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood to accelerate clotting. Moreover, when exposed to blood, the binder has low solubility and retains a majority of the clay material on the gauze. A bandage that can be applied to a bleeding wound to promote blood clotting includes a flexible substrate and a gauze substrate mounted thereon.

Abstract: Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment. For example, in some embodiments, tissue patches are made by applying a compressive force to a liquid medium comprising fibrinogen (and/or fibrin) between two surfaces (e.g., within a syringe or other chamber). A filter can be placed within or near the volume in which the compressive force is applied to the liquid medium such that unwanted material (e.g., water, blood cells, and the like) is passed through the filter while desirable components (e.g., fibrin, fibrinogen, and/or other desirable components) are retained by the filter to form the patch. In this way, the concentration of fibrin (and/or fibrinogen) within the liquid medium can be increased, potentially dramatically, as the compressive force is applied to the liquid-containing composition.

Abstract: An article comprising a polyelectrolyte complex comprising an interpenetrating network of at least one predominantly positively charged polyelectrolyte polymer and at least one predominantly negatively charged polyelectrolyte polymer, the polyelectrolyte complex further comprising a plurality of closed-shell pores, the plurality of pores having at least one average transverse dimension between about 100 nanometer and about 1000 micrometers.

Abstract: Disclosed herein are compositions and methods for making germanium-based glass polyalkenoate cements. Also disclosed are methods for their use as bone cements for bone augmentation procedures.

Abstract: Non-antigenic, resilient, bioremodelable, biocompatible tissue prostheses that can be engineered into a variety of shapes and used to repair, augment, reconstruct or replace damaged or diseased biological structures and associated tissue.

Abstract: An implantable structure, method for making the structure and method for using the structure, where the structure includes a combination of non-absorbable and absorbable components, and the implantable structure has a randomly uniform array of materials. The resulting implantable structure provides improved tissue ingrowth and flexibility after implantation and after absorption of the absorbable materials.

Abstract: Mixtures made of PE and COC, in particular for use in medical materials, so as to reduce the frictional forces. The mixtures comprising or consisting of PE and COC, wherein ?70% by weight, preferably ?90% by weight, and still more preferably 100% by weight, relative to the total mass of PE, of PE in the mixture is HDPE.

Abstract: A functional film that is applied to a surface of a medical apparatus or a biomaterial includes a film of Ti-doped tetrahedral amorphous carbon (ta-C:Ti film).

Abstract: A method of manufacturing nitrile rubber latex medical examination gloves during which (a) the glove formers are dipped into a coagulant solution containing divalent calcium cations and calcium nitrate particles, to which has been added a composition comprising Alcohol ethoxylate, Amine oxide, Ethylenediaminetetracetic acid, Glutaraldehyde, Chlorhexidine di-gluconate, Chlorhexidine di-hydrochloride, Salisept, Titanium Dioxide, nano particle silver; and during which (b) the coated glove formers are then dipped into a nitrile rubber latex dispersion to which has been added a composition comprising Alcohol ethoxylate, Amine oxide, Lactic acid, Ethylenediaminetetracetic acid, Glutaraldehyde, Salisept; and during which (c) the nitrile rubber latex gloves are finally placed in to packaging utilizing a clear coat varnish that it is impregnated with a phenolic chlorine compound, micronized nanosilver colloid, and a quaternary compound.

Abstract: An apparatus for promoting granulation and epithelialization at a tissue site having a substantially gas impermeable, flexible mat. A plurality of projections extend from a surface of the substantially gas impermeable, flexible mat, and each projection has a first end connected to the surface and a second end opposing the first end. A flexible membrane is positioned adjacent the second end of at least a portion of the plurality of projections and the flexible membrane is sufficiently flexible to allow deformation of the flexible membrane by the at least the portion of the plurality of projections when a biasing force exerted on the substantially gas impermeable, flexible mat or the plurality of projections is greater than or equal to a threshold force.

Abstract: A system for stimulating the healing of tissue comprises a porous pad positioned within a wound cavity, and an airtight dressing secured over the pad, so as to provide an airtight seal to the wound cavity. A proximal end of a conduit is connectable to the dressing. A distal end of the conduit is connectable to a negative pressure source, which may be an electric pump housed within a portable housing, or wall suction. A canister is positioned along the conduit to retain exudates suctioned from the wound site during the application of negative pressure. A controller for automated oscillation of pressure over time is provided to further enhance and stimulate the healing of an open wound. A power management motor control for varying pump drive frequency and managing a portable power supply is provided to increase battery life and improve patient mobility.

Abstract: A rotational pump capable of running at a rotational speed (n) having a system for direct or indirect measurement of pressure difference or flow rate across the pump, wherein a control system is designed to calculate an index of pulsatility (PI) of the pressure difference or flow rate, estimating the gradient of PI with respect to the rotational speed (dPI/dn) and regulating the dPI/dn to a pre-defined set-point or regulating the pump in a way that the dPI/dn is minimal.

Abstract: An access disconnection system includes a venous line, an arterial line, a first electrode coupled to (i) the arterial line, (ii) a patient, or (iii) a cardiac catheter assembly; and a second electrode coupled to (i) the venous line, or (ii) the cardiac catheter assembly. The access disconnection system further includes electronic circuitry communicating electrically with the first second electrode to sense an electrical heartbeat signal generated by the patient. The electronic circuitry is configured to send a disconnection output indicative of a change in the electrical signal sufficient to expect that an access disconnection of the venous line has occurred.

Abstract: This invention relates to a safety needle accessory sealed within a pack suitable for sealing pre-filled syringes. The safety needle accessory comprises a hub for surrounding a hollow needle having a tip and having a connector for attachment to a syringe, a slidable sleeve adapted to slide over the needle in a first longitudinal direction from a first position in which the needle is fully or partially covered by the sleeve to a second position in which the needle is exposed, and in a second longitudinal direction from the second position to a third position in which the needle is fully covered by the sleeve, and a pack surrounding the hollow needle, hub and slidable sleeve having a closed end covering the needle and an open end exposing the connector of the hub. The safety needle accessory further comprises a first seal attached to the connector of the hub and a second seal between the hub and the pack.

Abstract: A burette (10) to receive liquid from an intravenous supply (29) to deliver liquid to a patient via a tube (30). The burette (10) includes a hollow body (11) that is generally cylindrical configuration and that contains a float valve (24). Liquid level in the chamber (12) of the body (11) regulates liquid level within the chamber (12) by engaging an inlet passage (36) or an outlet tube (25).

Abstract: A drip chamber for an infusion tube, including: a first end including a drip tube; a second end including an exit port; and a wall connecting the first and second ends and including an interior surface with a hydrophobic portion. The drip chamber includes a space enclosed by the interior wall and the first and second ends. The hydrophobic portion of the interior surface repels liquid contacting the hydrophobic coating. The hydrophobic portion of the interior surface enables light to refract through the hydrophobic portion and the wall in the same manner as is the case when the hydrophobic portion is not present on the interior surface.

Abstract: A fluid supply apparatus which supplies fluid to a medical apparatus includes: a pump mechanism including a first pump capable of a suction operation of the fluid after a feeding operation of the fluid, and a second pump capable of a suction operation of the fluid during the feeding operation and a feeding operation of the fluid during the suction operation; a flow path which includes an elastic member and which communicates with the first pump and the second pump and supplies the fluid to the medical apparatus; and a flow path deforming unit which deforms a part of the flow path. The flow path deforming unit starts first deformation of the flow path before the first pump switches from the feeding operation to the suction operation, and completes the first deformation and starts second deformation of the flow path during the feeding operation by the second pump.

Abstract: The invention relates to a drive device for linear movement of an infusion syringe piston of an infusion syringe disposed on an infusion pump comprising a drive head unit including a main bearing means for supporting the infusion syringe piston, a fixing means for securing the infusion syringe piston to the main bearing unit as well as means for triggering the fixing means and comprising an advancing means for the drive head unit including a motor-drivable advancing spindle and a multi-part advancing spindle nut having at least one radially movable nut shell, wherein the drive head unit additionally comprises detecting means for detecting the infusion syringe piston ahead of the main bearing means, the detecting means including a multi-threshold sensor unit comprising an at least two-stage upstream detection means for detecting different positions of the infusion syringe piston ahead of the main bearing means.

Abstract: A cannula for administration of a medicine to a target location includes a tube with at least one nodule disposed along the circumferential surface and spaced at a defined distance from the distal end of the tube. An arrangement for delivery of a medicine to a target location includes the cannula and a pump fluidly coupled to the cannula. The distal end of the cannula may be inserted into a target location until the nodule reaches a surface that limits a depth of penetration before delivery of the medication.

Abstract: A medical device includes a catheter having an opening formed in a side portion of the catheter, an infusion tubing extending within the catheter along an axial direction of the catheter; an infusion needle disposed at a distal portion of the infusion tubing, a connecting part which bendably connects the infusion needle to the distal portion of the infusion tubing, and a bending unit by which the infusion needle located inside the catheter so as to face the opening is bent at the connecting part at essentially a right angle with respect to the distal portion of the infusion tubing.

Abstract: A one-way valve for medical infusion lines includes a first tubular connector and a second tubular connector, which define, respectively, an upstream passage and a downstream passage, which are coaxial and set transversely between which is a diaphragm made of elastically deformable material co-operating in a fluid-tight way with an annular seat to keep the valve normally closed. A filter, integrated in the valve, is axially clamped and blocked between the first tubular connector and the diaphragm.

Abstract: Describe is an auto-injector comprising a syringe carrier arranged to retain a syringe, a plunger arranged to displace a stopper within the syringe, a feedback component retainable in a first position and biased towards a second position, a pin disposed on the feedback component, and an exterior component having a bore. The feedback component moves from the first position to the second position when the plunger during displacement of the stopper reaches a predetermined position. The pin enters the bore when the feedback component is in the second position.

Abstract: Auto-injector for administering a dose of a liquid medicament includes a housing to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), the housing having a distal end (D) and a proximal end (P) with an orifice to apply against an injection site. A spring means, upon activation, can push the needle from inside the housing through the orifice and past the proximal end (P), operate the syringe to supply the dose of medicament (M), and retract the syringe with the needle after delivering the medicament (M). An activating means can lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.

Abstract: An auto-injector comprising a housing arranged to contain a syringe. The syringe is slidably arranged with respect to the housing, a spring capable of pushing a needle from a covered position into an advanced position, operating the syringe to supply a dose of medicament, and retracting the syringe into a covered position and an activator. The spring is arranged to be grounded in the housing for advancing the needle and for injecting the dose of medicament. The drive spring grounded in the housing switched to its proximal end for retracting the syringe. An interlock sleeve telescoped within the housing. The activator comprises a trigger, wherein the trigger button is locked, thereby preventing actuation when the interlock sleeve is in its proximal position in an as delivered state and wherein translation of the interlock sleeve unlocks the trigger button so as to allow actuation.

Abstract: An auto-injector comprising a tubular chassis, a carrier subassembly comprising a tubular carrier slidably arranged partially inside the chassis, a drive spring and a plunger, the syringe is lockable for joint axial translation with a carrier, a control spring, and a needle insertion control mechanism comprising a first collar biased by the control spring in a proximal direction. At least one resilient beam is proximally arranged on the first collar, wherein respective recesses are arranged in the carrier and case. A transversal extension of a head of the resilient beam is wider than a gap between the carrier and the chassis causing the head of the resilient beam to abut a distal face on the recess in the chassis.

Abstract: An apparatus includes a housing, a medicament container, an actuator, and a biasing member. The actuator is configured to move the medicament container within the housing when the actuator is moved from a first configuration to a second configuration. The actuator includes a gas container and a puncturer. When the actuator is in the first configuration, a portion of the puncturer is disposed apart from the gas container. When the actuator is in the second configuration, the portion of the puncturer is disposed within the gas container. The gas container has a longitudinal axis offset from a longitudinal axis of the medicament container. The biasing member is configured to bias the actuator toward the second configuration.

Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament contained within a capsule having an integral flow distributor/distribution system and where both medicaments are delivered through a single hollow needle.

Abstract: A safety syringe with a plunger in which a needle is attached to a mobile component that is mechanically not linked to the plunger but is slidable within the barrel of the syringe and has a valve mechanism for opening a port connecting the interior volume between the mobile component and the plunger to the needle bore. The mobile component is first pushed by the plunger to the bottom of the barrel so that the needle extends normally, the mobile component is mechanically locked in place for use conventionally, and the needle bore is opened. After use, the needle bore may be closed, the lock released, and the mobile component and attached needle sucked back into the barrel by pulling the plunger out, retracting the used needle into the barrel. There may be a plunger lock. There may be an upper barrel locking position for the mobile component.

Abstract: A catheter proximal section is preferably formed from a relatively soft part and a relatively rigid part, and includes a proximal terminal end that defines a perimeter of an opening into a lumen of the catheter. The proximal section may further include a feature for interlocking engagement with an accessory tool. An inner surface of each of the relatively soft and rigid parts may be located opposite one another, on either side of the catheter lumen. The relatively soft and rigid parts may be included in a sealing assembly that further includes an attachment feature for removable connection of the assembly to the proximal section catheter.

Abstract: A container system includes a first container assembly and a delivery device. The first container assembly has an administration port and a medication port. The delivery device is attached to the first container assembly, and includes a housing, a connector, a second container, and a plunger shaft. The housing encloses an interior space with the medication port disposed within the interior space. The connector has at least one cannula defining a first sharp end aligned with the medication port and a second sharp end. The second container has an outlet port aligned with the second sharp end of the at least one cannula and a plunger seal moveable within the second container to force contents of the second container through the port. The plunger shaft assembly has a first end that abuts the plunger seal and a second end connected to a trigger.

Abstract: A reduced profile syringe assembly is provided that includes an overall profile that is substantially similar to a profile of a syringe barrel. The syringe assembly includes a plunger rod that is significantly disposed within the syringe barrel when filled for use, with the plunger rod adapted to be retracted from the syringe barrel during dispensing of contents of the syringe barrel.

Abstract: A spindle (242; 414; 542; 642) for driving a bung of a cartridge is provided. The spindle includes a generally circular shaft having an outer surface (560). The generally circular shaft extends from a distal end to a proximal end of said circular shaft. A first helical groove (219; 519; 619) is provided along a first portion of the outer surface. The first helical groove having a first pitch. A second helical groove (221; 521; 621) provided along a second portion of the outer surface of the generally circular shaft. The second helical groove overlapping the first helical groove. The second helical groove having a second pitch.

Abstract: A first input member and a second input member are arranged along a first axis and coupled in such a manner that a movement of the first input member along the first axis is converted into a rotational movement of the second input member with respect to the body . A first output member and a second output member are arranged along a second axis and coupled in such a manner that a rotational movement of the first output member is converted into a movement of the second output member along the second axis with respect to the body. The second input member and the first output member are releasably rotationally coupled.

Abstract: According to the invention, a safety device for a pre-filled syringe comprises a hollow support body for mounting the pre-filled syringe therein, a hollow needle shield that is slidable relative to the support body and guiding means for guiding the movement of the needle shield relative to the support body. The guiding means comprise a flexible arm with a guide pin, a guide track and a separating wall. The guide pin extends from the flexible arm in a radial direction, and protrudes into the guide track. The separating wall extends into the guide track in a direction parallel to a central axis of the safety device. When the needle shield is slid relative to the support body the guide pin moves along the guide track to deflect the flexible arm in a lateral direction perpendicular to the central axis and the movement of the guide pin along the guide track is guided by the interplay of the flexible arm and the separating wall.

Abstract: Described is a needle safety device comprising a needle hub having a radial protrusion, a needle coupled to the needle hub and having a distal tip, and an inner sleeve telescopically coupled to the needle hub. The inner sleeve includes a first track adapted to engage the radial protrusion. The first track includes an axial section and a radial section. When the inner sleeve is in a first advanced position (PA1) and a first angular position (P1) relative to the needle hub, the radial protrusion is engaged in the first track and the distal tip is covered. When the inner sleeve is in a retracted position (PR) relative to the needle hub, the radial protrusion is in the axial section and the distal tip is exposed. When the inner sleeve is in a second advanced position (PA2) relative to the needle hub and a second angular position (P2), the radial protrusion is in the radial section and the distal tip is covered.

Abstract: According to the invention, a safety device for a pre-filled syringe with an injection needle comprises of a support body adapted to mount the pre-filled syringe, a needle shield slidably arranged with respect to the support body, a retention and locking means (M) for retaining and locking the needle shield with respect to the support body in a first and a second advanced position (PA1, PA2) and in a retracted position (PR). The needle shield comprises an annular flange adapted to rest on the skin of the patient receiving an injection. The retention and locking means (M) are arranged at a distal end of the safety device.

Abstract: A safety shield adapted for use with a syringe having a syringe barrel for protecting a needle after use in a medical procedure is disclosed. The safety shield includes a first portion disposed at least partially about the barrel and axially movable from a retracted position surrounding at least a portion of the syringe barrel to an extended position wherein at least the distal end of the first portion extends beyond the distal end of the syringe barrel. The shield further includes a second portion associated with the first portion and axially movable with respect to the first portion from a retracted position to an extended position extending beyond the distal end of the first portion, First and second locking members are provided for locking the first and second portions in an extended position upon axial movement thereof.

Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed. The drug delivery device includes a push rod operably connected to a dose dial button. The medicated module includes a housing having a connector configured for attachment to the drug delivery device, and the housing is configured to receive a portion of the push rod when the medicated module is attached to the drug delivery device. The medicated module further includes a reservoir in the housing comprising a single dose of a medicament and a needle guard operably connected to the housing and configured to move in an axial direction during application to an injection site. Still further, the medicated module includes a sleeve in the housing configured to move axially in the housing and a locking collar in the housing configured to move axially and rotationally in the housing.