Abstract: An electronic pill box for receiving a blister pack having a plurality of dosettes pre-loaded with doses of medication. The pill box includes a base module having a plurality of receptacles that receive the dosettes of the blister pack. The number of receptacles is sufficient to hold about a month of medication. A day module is engaged with the base module but is detachable therefrom. Individual dosettes are detached from the blister pack and loaded into receptacles in the day module. The base module and day module include capacitance sensors for determining if a dose of medication has been removed at the required time. The day module also includes a light sensor assembly that verifies whether the dosettes loaded into the day module's receptacles are the correct dosettes for the time of day a particular dose of medication should be taken.

Abstract: An adapter assembly includes a tapered connector including a central passage and a tapered outer surface for sealing with a tube or bottle. A male connector for connection to a female connector to fluidly communicate the female connector with the tube or bottle is coupled with the tapered connector. A method of forming such an adapter assembly is also disclosed.

Abstract: A system comprising a nasogastric tube comprising a nasogastric location element, a feeding mechanism, a suction mechanism configured to sealingly draw an inner wall of an esophagus against said nasogastric tube, and a gastric decompression mechanism.

Abstract: A plush animal shaped toy for intellectually stimulating, entertaining, and calming an infant-toddler, comprising at least: one rattle mechanism; one squeeze mechanism; a sound box to emit a recorded voice and/or melody; and a detachable pacifier with cover attached via Velcro-like material near the animal's mouth. The toy may further comprise visual symbols printed, stitched, or patched on the exterior animal surface, such as letters of the alphabet or numeric numbers. Exemplary embodiments comprise: a caterpillar; an elephant; a lamb; a monkey; and a puppy; and the sound box emits the ABC song when the designated animal's paw, hoof, or mid-section is pressed. The rattle mechanism is housed within the animal's head, and the squeeze and press mechanism and sound box are housed within the animal's body. A “Press” patch is sewn onto a hoof or paw bottom, or midsection and connected to the sound box via a wire.

Abstract: The present invention provides a pacifier having a mouthpiece, a shield and an attachment. The shield defines an aperture and the mouthpiece and attachment are removeably connectable through the aperture thereby to hold the shield in place. Alternatively, the mouthpiece and shield may be connected in such a manner that they cannot be detached and reattached, and the shield and attachment are removeably connectable. Further alternatively, the mouthpiece and the shield are removeably connectable, and the shield and attachment are removeably connectable.

Abstract: A disposable emesis bag comprising a soft cushioning material at the opening of the bag to improve the user's comfort while and after vomiting. The soft cushioning material can be attached only to the portions of the bag that come into contact with the user's nose or chin, or around the entire perimeter of the opening of the bag. The bag may be scented or odor-absorbing, and is preferably waterproof.

Abstract: Described herein is a cosmetic composition comprising a mixture of metal oxide pigments having different shapes and sizes which provides high coverage and a natural look upon application.

Abstract: This invention relates to a novel method of reducing the appearance of rhytides (“facial wrinkles”) and/or infra-orbital shadows (“dark circles”) under the eyes, and striae (“stretch marks”), or lentigo senilis (“age spots”), and hyper/hypo pigmentation on other anatomical areas. Particularly, this invention relates to a topical patch worn on the skin that in a preferred embodiment incorporates two distinct layers, each providing useful features and together providing a novel article and method of improving skin cosmesis. Ease of use, patient comfort and cost effectiveness are provided. The patch is applied to the affected area and preferably worn at least several hours and more preferably worn overnight. The product increases the hydration level of the skin over which it is applied. There is a slight increase to the volume of the local superficial tissue, which serves to tighten the overlying skin and reduce the size and quantity of fine wrinkles at least temporarily.

Abstract: A long lasting breath mint including a carrier and a flavorant, wherein the carrier includes at least one of a high viscosity cellulose ether and a low viscosity cellulose either and an alginate. The carrier forms a gel upon contact with saliva. A tablet is placed in the mouth of user, whereupon the tablet is wetted with saliva. A surface of the tablet is converted to a gel resulting in a tablet having an outer gel layer and a core. The gel serves as an adhesive for adhering the tablet to mouth structure. The gel slows exposure of the core to moisture and also slows diffusion of flavorant into the mouth of the user with the gel resulting in a breath mint having an extremely long life prior to complete dissolution, e.g., greater than 30 minutes or longer.

Abstract: The present invention relates to an oil/oil emulsion comprising at least: —a first oily phase comprising at least a first non-volatile oil chosen from silicone oils, hydrocarbon-based oils and fluoro oils, —a second oily phase comprising at least a second volatile or non-volatile oil, which is immiscible with the first oil(s) at room temperature, —solid microparticles having at least one curved part and at least one breakage of curvature of the said curved part. The invention also relates to a cosmetic composition comprising, in a physiologically acceptable medium, at least one such oil/oil emulsion. Finally, the invention relates to the use of solid microparticles having at least one curved part and at least one breakage of curvature of the said curved part, for stabilizing an oil/oil emulsion as has just been described.

Abstract: Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are described herein. The material(s) are encapsulated in an inert, non-bioerodible, hydrophobic, polymeric material. Methods of making microparticles encapsulating the personalizing substance and methods of use are also provided. The personalizing substance may be encapsulated in a polymeric non-bioerodible microparticle. The encapsulated personalizing substance may be combined with a carrier for delivery to an individual's skin. In some embodiments, the personalizing substance is added to a tattoo ink and incorporated in a tattoo created on an individual's skin. Following injection in the skin, the encapsulated material remains in the microparticles, and is not released over time.

Abstract: Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are described herein. The material(s) are encapsulated in an inert, non-bioerodible, hydrophobic, polymeric material. Methods of making microparticles encapsulating the personalizing substance and methods of use are also provided. The personalizing substance may be encapsulated in a polymeric non-bioerodible microparticle. The encapsulated personalizing substance may be combined with a carrier for delivery to an individual's skin. In some embodiments, the personalizing substance is added to a tattoo ink and incorporated in a tattoo created on an individual's skin. Following injection in the skin, the encapsulated material remains in the microparticles, and is not released over time.

Abstract: A microcapsule composition useful in delivering an active material contains a first microcapsule and a second microcapsule. The first microcapsule has a zeta potential of 10 mV or greater, the second microcapsule has a zeta potential of 5 mV or less, and the weight ratio of the first microcapsule and the second microcapsule is between 1:10 and 10:1. Also disclosed are consumer products containing such a microcapsule composition.

Abstract: Animate surface treatment compositions comprise (or in certain preferred embodiments may consist essentially of, or may consist of): a metal ion source material which releases copper ions and/or zinc ions into the treatment composition, in certain embodiments at least one alcohol which independently of other constituents present exhibits a microbicidal effect, in certain embodiments at least one quaternary ammonium compound which provides a microbicidal benefit, optionally but very preferably also at least one detersive surfactant, further optionally one or more further constituents which impart one or more advantageous technical or aesthetic benefits to the compositions, including one or more detersive surfactants, and water, wherein the compositions are at a pH such that the animate surface treatment compositions, exhibit a microbicidal or germicidal or antimicrobial effect on treated surfaces, which compositions are characterized in exhibiting a microbicidal benefit when tested against one or more challeng

Abstract: Kit for whitening a body surface of a user, comprising: an oxidizing composition application device (12); wherein the kit comprises an activator sheet (14) which is movable independently of the oxidizing composition application device (12), the activator sheet (14) comprising an outer deformable substrate (50) intended to be applied on an oxidizing composition (34) placed on the skin of the user, the activator sheet (14) comprising an activator composition (52) carried by the outer substrate (50).

Abstract: A beauty care product comprising a sealable plastic container, a sealing means and a beauty care component is provided, wherein the container of which is resistant to random, uncontrolled deformation under a substantial pressure differential between the environment and inside the container, yet having an affordable cost of manufacture and/or being appealing to the consumer. A kit comprising said product thereof, a method of manufacturing said product, and a method of using said product for application onto skin and/or hair are also provided.

Abstract: A product for oxidatively coloring and/or lightening keratinic fibers includes (1) a dispenser, which has two chambers (A) and (B) separate from one another; an outlet opening (C) communicating with chamber (A) and with chamber (B); (2) a preparation (a) in chamber (A), which preparation includes one or more thickening polymers in a total amount by weight (G1) of 0.1 to 20%, based on preparation (a); one or more fatty components in a total amount by weight (G2) of 0.1 to 20%, based on preparation (a); and (3) a preparation (b) in chamber (B), which preparation includes one or more thickening polymers in a total amount by weight (G3) of 0.1 to 20%, based on preparation (b), and one or more fatty components in a total amount by weight (G4) of 0.1 to 20%, based on the total weight of the preparation (b). The weight ratio of G1/G3 has a value of 0.5 to 2.0 and the weight ratio of G2/G4 has a value of 0.5 to 2.0.

Abstract: Agents for lightening keratin fibers include, relative to their weight, 20 to 75 wt.-% oil(s), 0.05 to 5 wt.-% xanthan, 1 to 70 wt.-% peroxodisulfate(s) and 1 to 15 wt.-% cetearyl alcohol. The agents have increased storage stability, not only the physical stability (settling, phase separation) but also the chemical stability (degradation of the persalts) thereof being improved.

Abstract: Cosmetic agents include liquid oils in a total amount of 80 to 99.5% by weight. The liquid oils include (a) at least one liquid oil with a spreadability value (25° C.) in a range of 100 mm2/10 min to less than 800 mm2/10 min, (b) at least one liquid oil with a spreadability value (25° C.) in a range of 800 mm2/10 min to less than 1050 mm2/10 min, (c) at least one liquid oil with a spreadability value (25° C.) in a range of 1050 mm2/10 min to 1800 mm2/10 min. The weight ratio of the total amount of the oils named under (a) to the sum of the respective total quantities of the oils named under (b) and (c) is in the range of 1 to 3 to 1 to 1. The cosmetic agents are suitable as skin care oils and provide a smooth skin feel and protect the skin against drying out.

Abstract: The present invention is directed to a rinse-off conditioner composition for hair frizz reduction comprising from about 0.2% to about 20% of a moisture control material or mixture of moisture control materials wherein the moisture control material is selected from one or more of the following: wherein R? is —COOY, sulfonic acid, or C?CH—COOY, Y is hydrogen or a metal ion, R1, R2, R3, R4, R5 is hydrogen, methyl, ethyl, propyl, vinyl, allyl, methoxy, ethoxy, hydroxyl, halogen, sulfate, sulfonate, nitro, or —CH?CH—COOR, and wherein the moisture control material is an acidic material and further wherein the moisture control material has a % Protein binding higher than 20 and Molecular Volume lower than 500 and Partition coefficient octanol to water (log P) lower than 3 and hydrogen binding higher than 10 and pKa lower than 5.0; and at least about a 4% fizz reduction vs. a control composition without the moisture control material.

Abstract: A product for the coloring and/or lightening of keratinic fibers includes (1) a dispenser, having two chambers (A) and (B); (2) a preparation (a) in chamber (A), including in a cosmetic carrier one or more fatty components in a total amount by weight (G1) of 0.1 to 40% by weight, based on (a), one or more organic and/or inorganic salts in a total molality (M1) of 0.01 to 1 mol/kg, based on the total weight of (a); 3) a preparation (b) in chamber (B), including in a cosmetic carrier one or more fatty components in a total amount by weight (G2) of 0.1 to 40% by weight, based on (b), one or more organic and/or inorganic salts in a total molality (M2) of 0.01 to 1 mol/kg, based on (b), wherein the weight ratio G1/G2 has a value of 0.5 to 2.0 and the molality ratio M1/M2 has a value of 0.3 to 3.0.

Abstract: A hair dye composition is characterized by containing (A) HC BLUE No. 2, (B) DISPERSE VIOLET 1, and (C) at least one of HC YELLOW No. 2 and HC YELLOW No. 4 and has a pH of 7-11. The mass ratio of the content of (A) HC BLUE No. 2 to the content of (B) DISPERSE VIOLET 1 is preferably 1 to 30. The hair dye composition preferably further contains (D) DISPERSE BLACK 9.

Abstract: Cosmetic compositions comprising substituted carbamoyl heterocyclic analogs and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The substituted carbamoyl heterocyclic analogs are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging.

Abstract: Disclosed is the Use of UV absorbers selected from (a1) diphenylacrylates; and (a2) hydroxyphenyl triazines of formula wherein R1 is —O—R5; —COOR6; or —CO—NHR7; R2 is —O—R8, —COOR9; or —CO—NHR10; R3 is —O—R11; —COOR12; or —CO—NHR13; R5, R6, R7, R8, R9, R10, R11, R12 and R13 independently from each other are C1-C18alkyl; R4 is hydrogen; or hydroxy; and x is 0; or 1; for stabilizing cosmetic compositions comprising an organic UV absorber selected from (b1) a benzophenone derivatives of formula wherein R14 and R15 independently from each other are; C1-C20alkyl; C2-C20alkenyl; C3-C10cycloalkyl; C3-C10cycloalkenyl; or R14 and R15 together with the linking nitrogen atom form a 5- or 6-membered heterocyclic ring; n1 is a number from 1 to 4; when n1=1, R16 is a saturated or unsaturated heterocyclic radical; hydroxy-C1-C5alkyl; cyclohexyl optionally substituted with one or more C1-C5alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C1-C5alkylcarboxy; when n1

Abstract: Compositions containing a solution of a polyfunctional aziridine component in a non-reactive solvent, and methods of applying such compositions to proteinaceous substrates, such as fingernails and toenails, to provide primed substrates which may be further coated.

Abstract: The present compositions include substantially anhydrous lotions, gels, or cremes having a high vitamin C content. The compositions described herein may be used as paste, lotions, cremes, or gels in and of themselves, or as a solvent/base system for additional ingredients. Additional ingredients may include therapeutically active ingredients, pigments, fragrances or other cosmetic additives.

Abstract: A composition directed to a rinse-off composition for hair frizz reduction comprising from about 0.2% to about 20.0% of a moisture control material or mixture of moisture control materials wherein the moisture control material is selected from one or more of the following: a) wherein R is hydrogen or metal ion, R6 is methyl, ethyl, propyl, alkenyl or phenyl having less than 12 carbon atoms and wherein R7, R8, R9, R10, R11, R12 are hydrogen, methyl, ethyl, propyl, phenyl, hydroxyl, methoxy or ethoxy groups; b) an alcohol wherein R13 is an alkyl, alkenyl, straight or branched carbon chains and; and wherein R14 is hydrogen, hydroxyl, alkyl, methyl, ethyl and propyl wherein the structure of such alcohol contains less than 20 total carbon atoms; c) alcohol comprising an unsaturated double bond in the C2 position.

Abstract: A personal care composition and method of using a personal care composition having menthol and/or hydrogen peroxide and a TRPA1 and/or TRPV1 receptor antagonists.

Abstract: The present invention generally relates to compositions and methods for transdermal delivery, and treatment of hair related conditions. The compositions can be used in a variety of applications, including causing or promoting hair growth and/or hair pigmentation. In some cases, the composition may include nitric oxide and/or peptides. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto the scalp, or other suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

Abstract: The present invention teaches a hair straightening system including formulations that will safely and effectively straighten curly hair for at least 2-3 months after a single application, despite frequent washings of the hair. Methods for obtaining said formulations are disclosed. Hair straightening systems including shampoo and one or more conditioners are also provided.

Abstract: Compositions of the invention comprise 8-oxoguanine glycosylase (OGG1) and SIRT6 activating peptide G-A-G-V-S-A-E-NH2. Compositions of the invention exhibit anti-aging effects by promoting the repair of skin cell DNA and/or by protecting skin cell DNA from UV damage.

Abstract: The present invention relates, in one aspect, to the use as dermal filler of a cross-linked biopolymer compatible with the tissues of the human organism based on hyaluronic acid cross-linked with urea. The biopolymer of hyaluronic acid and urea may be applied or injected in a soft tissue of human body for tissue augmentation.

Abstract: Agents for lightening keratinic fibers, which include, based on their weight, 20 to 75% by weight of oil(s), 0.05 to 5% by weight of polymer(s) from the group of ethylene/propylene/styrene copolymers and/or butylene/ethylene/styrene copolymers and/or butylene/propylene/styrene copolymers, and 1 to 70% by weight of peroxydisulfate(s), whereby the weight ratio of sodium peroxydisulfate in the agent to the total amount of peroxydisulfates in the agent is at least 0.2, possess increased storage stability, the improvement being not only in physical stability (sedimentation, phase separation) but also in chemical stability (degradation of the persalts). There are also improvements in product yield, spreadability of the application mixture, and the bleaching effect.

Abstract: An agent for lightening keratin fibers, which, with regard to its weight, includes 20 to 75 wt. % of oil(s), 0.05 to 5 wt. % of polymer(s) from the group of copolymers of ethylene/propylene/styrene and/or copolymers of butylene/ethylene/styrene, and/or copolymers of butylene/propylene/styrene, and 1 to 70 wt. % of peroxydisulfate(s), wherein the fibres contain 1 to 44 wt. % of potassium peroxydisulfate and 0 to <5 wt. % of sodium peroxydisulfate, and 0 to <5 wt. % of ammonium peroxydisulfate. The agent has increased storage stability, whereby not only the physical stability (settling, phase separation) but also the chemical stability (decomposition of the peroxide salts) is improved.

Abstract: Disclosed are compositions and methods for their use that include a combination of Rhododendron ferrugineum (alpine rose) extract, Oenothera biennis (evening rose) extract, trifluoroacetyl tripeptide-2, and a cosmetic acceptable vehicle.

Abstract: Disclosed are compositions and methods that can be used to improve the skin's visual appearance. In certain aspects, the compositions disclosed herein can include, for example, a combination of ingredients to exfoliate, reduce or eliminate irritation from exfoliation, renew the skin, increase skin radiance, sooth the skin, or increase skin smoothness. This combination of ingredients can be included in a wide-range of product formulations (e.g., serums, eye creams, toners, gels, masks, peels, etc.).

Abstract: The present invention relates to a container for an analyte-sensitive gel. When analyte contacts such a gel it causes a gel-sol transition resulting in decreased viscosity of the gel. Such gels can be used for controlling the rate of release of an agent from a reservoir in response to the concentration of an analyte. The container is configured to allow analyte to pass into the container and contact the gel and to allow agent to diffuse out of the container. Such a container may be implantable in the body of a subject and therefore it is preferred if the container is constructed from materials that can be tolerated by the body for a period of time. Advantageously, the container limits the swelling and dilution of gel contained within the container caused by the influx of water into the gel by osmosis. The container therefore maintains the gel in a desired conformation and ensures a predictable release profile of the agent.

Abstract: Ocular implant devices (10, 20, 121) for the delivery of a therapeutic agent to an eye (101, 301) in a controlled and sustained manner. Dual mode and single mode drug delivery devices (10, 20, 121) are illustrated and described. Implants (10, 20) suitable for subconjunctival placement are described. Implants (121, 10, 20) suitable for intravitreal placement also are described. The invention also includes fabrication and implementation techniques associated with the unique ocular implant devices (10, 20, 121) that are presented herein.

Abstract: A composition and method for administering an active agent to a pet, such as a dog, a cat or a horse. The composition may comprise a yogurt-based chewable delivery matrix and a plurality of water-soluble film pieces dispersed throughout the chewable delivery matrix. The composition may also comprise a delivery matrix having at least 15% by weight of crude protein and a plurality of water-soluble film pieces dispersed throughout the delivery matrix. The plurality of water-soluble film pieces encompass an active agent therein, wherein the active agent is rapidly released from the composition upon contact with saliva from the pet. At least a portion of the released active agents may be oromucosally absorbed by the pet.

Abstract: A method for treating a periodontal disease affecting a periodontal pocket of a patient. The method comprises inserting an oral delivery device into the periodontal pocket at a frequency of about once every 4 days to about once every 6 weeks. The oral delivery device is a controlled release solid unit dosage form suitable for insertion into a periodontal pocket of a patient, comprising a therapeutically effective amount of at least one anti-inflammatory agent, at least one antibacterial agent, or the combination of at least one anti-inflammatory agent and at least one antibacterial agent.

Abstract: A pharmaceutical composition suitable for use in a dry powder inhaler comprising 70 mass %-99.5 mass % of pharmaceutically acceptable carrier suitable for use in dry powder inhalation formulation and 0.1 mass %-12.5 mass % of salmeterol xinafoate and 0.4 mass %-17.5 mass % of fluticasone propionate.

Abstract: The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.

Abstract: Disclosed is a water-in-oil-in-water (W/O/W) double emulsion including a first water phase, an oil phase and a second water phase, wherein the W/O/W double emulsion is disposed in an isotonic solution, and related methods of making the W/O/W double emulsion. Also disclosed is a method of making an artificial antigen presenting cell including: providing a W/O/W double emulsion that is stored in an isotonic solution, wherein the W/O/W double emulsion includes a peptide associated with a Major Histocompatibility (pMHC) complex or a glycolipid antigen associated with a CD1d molecule, and a costimulatory molecule; and transferring the W/O/W double emulsion to an electrolyte solution, wherein the double emulsion undergoes a morphological transformation to become the artificial antigen presenting cell. Also disclosed is a method of drug delivery including administering to a subject a unilamellar vesicle containing the drug.

Abstract: A method for prevention and/or treatment of diminution of bone tissue using a composition comprising a compound selected from Withaferin A (WFA), Withanolide A, and Withanone. The composition showed enhanced WFA bioavailability in rodents against plain WFA, promotes bone marrow cell differentiation, and increases the percent of bone volume to tissue volume (BV/TV%) by 3 folds as compared to free Withaferin A (WFA).

Abstract: The present invention relates to novel multicompartmental lipid nanoparticles (or cellisomes) with excellent stability comprising a first lipophilic compartment (lipid matrix) partly anchored to a second hydrophilic compartment delimited by a phospholipid bilayer (bilayer), as well as the method for preparing same and the use thereof as a vector for administering a wide variety of molecules of interest.

Abstract: Hollow, protein vesicles are provided. The protein vesicles can be loaded with desired cargo to be delivered to a subject, for example a human. One embodiment provides a protein vesicle made of a protein membrane surrounding a hollow core. The protein membrane includes a first and a second modular protein amphiphile. The first modular protein amphiphile includes a hydrophobic block and a first hydrophilic protein binding block. The second modular protein amphiphile includes a variable polypeptide block and a second hydrophilic protein binding block that binds to the first hydrophilic protein binding block. The first and second protein amphiphiles self-assemble to form the hollow, protein vesicle.

Abstract: Disclosed is process for preparing magnetic nanoparticles (MNPs) that results in very sensitive MNPs that can be used in a variety of diagnostic and analytical methods. The MNPs exhibit superparamagnetism and find special use in giant magnetoresistance sensors (GMRS). The MNPs are created by a process that permits one to tune the size of nanoparticles to a range of from 10 to 20 nanometers with a very small particle size distribution of +/?2 nanometers or less. The MNPs can be tagged with a variety of markers and thus find use in many analytical assays, cell sorting techniques, imaging methods, drug delivery methods and cancer treatments. The inventive MNPs can be detected in magnetic file strengths of 2000 Oe or less.

Abstract: Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution.

Abstract: The present invention relates to an oral pharmaceutical fixed dose composition for use in the treatment of tuberculosis, said oral pharmaceutical composition comprising: a) granules comprising isoniazid and at least one intragranular excipient, b) granules comprising rifapentine and at least one intragranular excipient, and c) at least one extragranular excipient, and to its process of preparation.

Abstract: In certain embodiments, the present invention is directed to a solid controlled release dosage form comprising: a core comprising a first portion of an opioid analgesic dispersed in a first matrix material; and a shell encasing the core and comprising a second portion of the opioid analgesic dispersed in a second matrix material; wherein the amount of opioid analgesic released from the dosage form is proportional within 20% to elapsed time from 8 to 24 hours, as measured by an in-vitro dissolution in a USP Apparatus 1 (basket) at 100 rpm in 900 ml simulated gastric fluid without enzymes (SGF) at 37 C.