Patents Issued in July 12, 2016
  • Patent number: 9389185
    Abstract: Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a partial least squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: July 12, 2016
    Assignee: MannKind Corporation
    Inventors: Jason J. Antunovich, Arthur T. Hamfeldt, Rodney J. Woods, Sam C. Shum
  • Patent number: 9389186
    Abstract: A scattering spectroscopy nanosensor includes a nanoscale-patterned sensing substrate to produce an optical scattering response signal indicative of a presence of an analyte when interrogated by an optical stimulus. The scattering spectroscopy nanosensor further includes a protective covering to cover and protect the nanoscale-patterned sensing substrate. The protective covering is to be selectably removed by exposure to an optical beam incident on the protective covering. The protective covering is to prevent the analyte from interacting with the nanoscale-patterned sensing substrate prior to being removed.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: July 12, 2016
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Gary Gibson, Zhiyong Li, Alexandre M. Bratkovski, Shih-Yuan Wang, Huei Pei Kuo, Steven J Barcelo, Zhang-Lin Zhou
  • Patent number: 9389187
    Abstract: Optical inspection systems and methods for inspecting a glass sheet for defects are disclosed. The systems and methods employ a digital camera and a plurality of different types of illumination sources. The object plane of the digital camera moves through the glass sheet body while flash exposures from one or more of the illumination sources are performed. The movement occurs during a ready-to-acquire time of the digital camera. This allows the digital camera to capture a plurality of digital inspection images on the fly at different exposure positions within the glass sheet body without waiting for any digital image processing to occur. The digital inspection images are then reviewed to characterize any revealed defects.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: July 12, 2016
    Assignee: CORNING INCORPORATED
    Inventor: William John Furnas
  • Patent number: 9389188
    Abstract: A structure for testing a luminescent film includes a Lambertian light source, an integrating sphere having an input port, and a measuring device. The Lambertian light source includes a mixing chamber having an input port and an output port, and a light emitter coupled to the input port. During testing the luminescent film is positioned between the output port of the mixing chamber and the input port of the integrating sphere. The measuring device is optically coupled to the integrating sphere.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: July 12, 2016
    Assignee: Koninklijke Philips N.V.
    Inventors: Dmitri Simonian, Mikhail Fouksman
  • Patent number: 9389189
    Abstract: The invention relates to a dark-field semiconductor wafer inspection device including, in the following order, a light source for emitting an incident beam to a wafer along a first axis, a concentrator that is symmetrical in relation to a plane passing through the first and second axes and is provided with a mirror that is elliptically cut along a plane perpendicular to an axis perpendicular to the first axis and has a generator parallel to the first axis, parallel first and second slits being set up sideways in first and second portions of the concentrator at the points for concentrating the light that is scattered by the wafer and reflected by the second and first portions of the concentrator, respectively, and a photomultiplier using a slit.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: July 12, 2016
    Assignee: Altatech Semiconductor
    Inventors: Philippe Gastaldo, Frederic Pernot
  • Patent number: 9389190
    Abstract: An X-ray CT apparatus includes an X-ray tube, X-ray detector detecting the X-rays transmitted through an object, data acquisition unit acquiring projection data of the object based on an output from the X-ray detector, bed driving control unit moving a top to place the object along a long-axis direction of the top, image processing unit generating a reconstructed image based on the projection data, positional shift amount detection unit detecting a shift amount of a relative position between the top and the object, and positional shift processing unit performing processing based on a detection result obtained by the positional shift amount detection unit, in accordance with movement of the top by the bed driving control unit.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: July 12, 2016
    Assignees: KABUSHIKI KAISHA TOSHIBA, Toshiba Medical Systems Corporation
    Inventor: Masaharu Tsuyuki
  • Patent number: 9389191
    Abstract: A system is provided. The system includes a conveyor apparatus configured for conveying a material and a water content measurement system positioned about the conveyor apparatus for determining water content in the material. A dimension characteristic measurement system for detecting one or more dimension characteristics of the material is provided and a computer device is configured to manipulate data received from the water content measurement system and the dimension characteristic measurement system to determine a water content of the material.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: July 12, 2016
    Assignee: Troxler Electronic Laboratories, Inc.
    Inventors: Wewage Hiran Linus Dep, Robert Ernest Troxler
  • Patent number: 9389192
    Abstract: A method for inspection includes capturing an optical image of one or more features on a surface of a sample and irradiating an area of the sample containing at least one of the features with an X-ray beam. An intensity of X-ray fluorescence emitted from the sample in response to the irradiating X-ray beam is measured. The optical image is processed so as to extract geometrical parameters of the at least one of the features and to compute a correction factor responsively to the geometrical parameters. The correction factor is applied to the measured intensity in order to derive a property of the at least one of the features.
    Type: Grant
    Filed: March 23, 2014
    Date of Patent: July 12, 2016
    Assignee: BRUKER JV ISRAEL LTD.
    Inventors: Alex Tokar, Alex Dikopoltsev, Isaac Mazor, Matthew Wormington
  • Patent number: 9389193
    Abstract: A slice-selective CPMG pulse sequence with a DANTE-Z selective scheme for measuring spatially-resolved T2 distributions.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: July 12, 2016
    Assignee: University of New Brunswick
    Inventors: Oleg Petrov, Bruce Balcom
  • Patent number: 9389194
    Abstract: Disclosed are improved methods and apparatus for determining a kinetic parameter of a sample via thermogravimetry. According to the methods, accuracy of the measured parameter is improved and made less susceptible to noise across a temperature range, in particular at near-zero values of the rate of change of the weight of the sample. The disclosed methods avoid taking a logarithm of the first derivative of a thermogravimetric signal related to the sample weight detected during the experiment.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: July 12, 2016
    Assignee: NETZSCH-GERAETEBAU GMBH
    Inventor: Elena Moukhina
  • Patent number: 9389195
    Abstract: A wear sensor comprising: an insulating substrate having a top surface and a bottom surface; a conductive electrode formed on said top surface of said insulating substrate; an insulating wear lining material having a first side secured to said top surface of said insulating substrate and conductive electrode, an opposite second side that will be worn down by relative motion between the wear sensor and a moving component; one or more contact points where the electrical properties between the electrode and the moving component can be measured; and one or more perforations through the thickness of the substrate and electrode, through which an adhesive may flow, thereby increasing the peel strength between the wear sensor and race or between the wear sensor and the wear liner.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: July 12, 2016
    Inventors: Iosif Izrailit, David L. Carnahan, Grant A. Drew, Richard R. Soelch
  • Patent number: 9389196
    Abstract: The water-concentration detection device for detecting a water concentration of insulating gas filled in a gas-insulated device includes: porous electrodes having porous properties that are arranged to face each other in the insulating gas; a solid electrolyte membrane that is sandwiched between and fixedly attached to the electrodes and has hydrogen-ion conductivity; a voltage application unit that applies an alternating-current voltage at a frequency of 325 Hz or a frequency of 10 Hz or lower to the electrodes; an impedance measurement unit that measures an alternating-current impedance between the electrodes in a state in which the alternating-current voltage is applied to the electrodes; and a water-concentration detection unit that detects the water concentration of the insulating gas based on the alternating-current impedance measured by the impedance measurement unit.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: July 12, 2016
    Assignee: MITSUBISHI ELECTRIC CORPORATION
    Inventors: Tatsuya Yabe, Yoshiyuki Tamura, Chieko Nishida
  • Patent number: 9389197
    Abstract: A method for detecting a defect of a barrier film includes preparing a device including an electrode and a barrier film covering the electrode, allowing a charged medium to contact a surface of the barrier film, and measuring a change in a flow of current between the charged medium and the electrode.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: July 12, 2016
    Assignee: Samsung Display Co., Ltd.
    Inventors: Alexander Voronov, Gyoo-Wan Han, Ji-Hun Jung
  • Patent number: 9389198
    Abstract: Methods and systems are provided for an engine coupled capacitance-based humidity sensor. Degradation of the humidity sensor may be determined based on humidity readings while flowing gasses into an engine intake air downstream of the humidity sensor and upstream of a compressor change by less than a first threshold while pressure at the sensor changes greater then a second threshold. The variation in pressure can be changed by adjusting a throttle upstream and downstream of the compressor based on whether the humidity sensor is degraded or functional.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: July 12, 2016
    Assignee: Ford Global Technologies, LLC
    Inventors: Ross Dykstra Pursifull, Imad Hassan Makki, Timothy Joseph Clark, Michael James Uhrich, Pankaj Kumar
  • Patent number: 9389199
    Abstract: The present disclosure provides a bio-field effect transistor (BioFET) and a method of fabricating a BioFET device. The method includes forming a BioFET using one or more process steps compatible with or typical to a complementary metal-oxide-semiconductor (CMOS) process. The BioFET device includes a substrate, a transistor structure having a treated layer adjacent to the channel region, an isolation layer, and a dielectric layer in an opening of the isolation layer on the treated layer. The dielectric layer and the treated layer are disposed on opposite side of the transistor from a gate structure. The treated layer may be a lightly doped channel layer or a depleted layer.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: July 12, 2016
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Chun-Wen Cheng, Yi-Shao Liu, Fei-Lung Lai, Wei-Cheng Lin, Ta-Chuan Liao, Chien-Kuo Yang
  • Patent number: 9389200
    Abstract: A sensor device according to an embodiment includes a semiconductor substrate including a plurality of channels, the channels connecting a cavity and a measurement electrode, and a counter electrode arranged to be in contact with the cavity, wherein the cavity, the measurement electrode and the counter electrode are arranged to accommodate a drop of a liquid and to allow a voltage to be applied to the drop of liquid.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: July 12, 2016
    Assignee: Infineon Technologies AG
    Inventor: Friedrich Kroener
  • Patent number: 9389201
    Abstract: An electromagnetic probe for non-destructive inspection of a twisted tube of a twisted tube heat exchanger comprising a probe body having a sensing section being configured to allow circulation of the probe body within the length of circular tube and the length of helical oval tube and to allow displacement of the electromagnetic sensor(s) from a radially inward contracted position to a radially outward expanded position in close proximity to an interior surface of a crest of the oval tube; a conduit attached to a proximal end of the probe body, the at least one conductor extending within the conduit to a remote end of the electromagnetic probe.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: July 12, 2016
    Assignee: EddyFi NDT inc.
    Inventors: Olivier Lavoie, Martin Bourgault, Marc Grenier, François Dion
  • Patent number: 9389202
    Abstract: A damage detecting device according to one aspect of the present invention comprises a first speed generator, a second speed generator, a first waveform shaping section, a second waveform shaping section, and a determining section. The determining section compares a second rectangular wave shaped by the second waveform shaping section and a first rectangular wave shaped by the first waveform shaping section and, if the first rectangular wave is not output while the second rectangular wave is output, determines that a supporting device for an armature shaft is damaged or worn.
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: July 12, 2016
    Assignee: CENTRAL JAPAN RAILWAY COMPANY
    Inventors: Mamoru Tanaka, Masayuki Ueno, Yoshiya Watanabe, Hirokazu Kato
  • Patent number: 9389203
    Abstract: Image data and E-mode images used in ultrasonic elasticity imaging may be automatically evaluated for quality to provide a single value used as operator feedback or for automatic selection of images for averaging or animation.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: July 12, 2016
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jingfeng Jiang, Timothy Jon Hall, Amy Marie Sommer
  • Patent number: 9389204
    Abstract: A method for characterizing ultrasound scatterers in a medium comprising providing ultrasound data representing a region of interest comprising a plurality of scatterers in a medium, the plurality of scatterers including clusters of scatterer sub-units, the scatterers having a physical property value to be estimated and the scatterer sub-units having at least one known physical parameter value; modelling the ultrasound data using an at least second order function of a spatial organization parameter defining the spatial organization of the scatterers; and estimating the physical property value of the scatterers from the modelled ultrasound data and the at least one known physical parameter of the sub-units by a regression of the spatial organization parameter as a function of frequency. A system for characterizing ultrasound scatterers is also included.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: July 12, 2016
    Assignee: VAL-CHUM, LIMITED PARTNERSHIP
    Inventors: Guy Cloutier, François Yu, Emilie Franceschini, David Savery
  • Patent number: 9389205
    Abstract: A solution for evaluating the condition of a rail component based on resonant response profiles across a set of bands of vibrations. The vibrations can be induced into the target component during normal operation of the target component. The resonant response profile of the rail component can vary depending on wear or damage, and thus can be used to determine whether the rail component can safely remain in use. An embodiment comprises an isolated segment of rail of a length selected to allow a single railroad wheel on it at a time, with a set of devices which can induce specific vibrations into the wheel as it passes, and another set of devices which can acquire the resonance signals from the wheel.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: July 12, 2016
    Assignee: International Electronic Machines Corp.
    Inventors: Zahid F. Mian, William B. Johnson
  • Patent number: 9389206
    Abstract: An array probe 3 is provided with an array probe body 32 having a plurality of transducers 31 linearly arranged. The array probe is provided with a vibration insulating member 4 that is installed onto a transducer surface 33 to absorb the vibrations of the transducer surface, and an installation frame 5 for installing the vibration insulating member. The vibration insulating member has an opening part 41, and the width dimension of the opening part is smaller than the width dimension of the transducer surface. By installing the vibration insulating member having the opening width dimension corresponding to the distance from a test object surface of a target flaw onto the transducer surface, ultrasonic testing is performed, whereby even for a flaw near the surface, flaw echo is made less liable to be buried in surface echo, and the flaw can be detected easily.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: July 12, 2016
    Assignee: NIPPON STEEL & SUMITOMO METAL CORPORATION
    Inventor: Hitoshi Murakoshi
  • Patent number: 9389207
    Abstract: A portable gas analyzer comprising an integrated micro-flame ionization detector (micro-FID), a micro-gas chromatograph (micro-GC), an electrolyzer, and a flame-shaped electrode are provided. The components of the portable gas analyzer can be integrated into a single “lunchbox” sized housing with all the peripherals required to operate the micro-GC/FID without an external power and gas supply.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: July 12, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: Mona L. Shannon
  • Patent number: 9389208
    Abstract: A planar manifold includes a first, generally planar, layer having a plurality of apertures therethrough. A second layer has a plurality of apertures therethrough. A channel layer defines a plurality of channels therein and is interposed between the first layer and the second layer. At least one channel extends in a direction parallel to a plane of the planar manifold and couples an aperture of the first layer to an aperture of the second layer.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: July 12, 2016
    Assignee: Rosemount Analytical Inc.
    Inventors: Edward J. Bailey, Jason P. Pratt, Shane Hale, Gregory J. Golden
  • Patent number: 9389209
    Abstract: To determine the concentration of an oxoanion in an aqueous solution, an aluminum reagent is added to the aqueous solution to form an optical analysis solution. Addition of the aluminum reagent may or may not form an alumino-oxoanion hydroxide hydrate precipitate. Light is directed into the optical analysis solution to determine an optical response of the optical analysis solution. Thereafter, the concentration of the oxoanion in the aqueous solution is determined based on the optical response of the optical analysis solution. For example, the concentration of the oxoanion may be calculated using a molar ratio relating oxoanion concentration to aluminum reagent concentration, when the aluminum reagent concentration corresponds to an inflection point of the optical response of the optical analysis solution.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: July 12, 2016
    Assignee: ECOLAB USA INC.
    Inventors: Nicholas S. Ergang, Ronald V. Davis
  • Patent number: 9389210
    Abstract: Provided is a thermal distribution display including, on a support, a thermal distribution display layer that includes at least two electron-donating dye precursors that develop mutually different color tones, the dye precursors including at least one electron-donating dye precursor that decomposes in a temperature range of 190° C. or higher to undergo a change in hue; at least one electron-accepting compound that allows the at least two electron-donating dye precursors to develop colors; and a binder, wherein, in the thermal distribution display layer, a temperature T0.2, at which a density is 0.2 greater than a background density, satisfies the following formula (1). 0.2 T 0.2 - T min ? 0.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: July 12, 2016
    Assignee: FUJIFILM Corporation
    Inventor: Kunihiko Ooga
  • Patent number: 9389211
    Abstract: The present invention relates to a device for investigating, measuring and/or detecting properties of chemical and/or biological fluids as well as to a device for performing these procedures and a system comprising a holder for holding at least one of said devices. A device for detecting properties of chemical and/or biological fluids may comprise a tubular structure with a cavity for accommodating the fluid, the tubular structure comprising a magnetizable and/or magnetic material, wherein the tubular structure comprises a segment that is transparent to light of wavelength 200 nm to 2000 nm.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: July 12, 2016
    Assignees: Nanotemper Technologies GmbH, Hirschmann Laborgerate GmbH & Co. KG
    Inventors: Stefan Duhr, Philipp Baaske, Hans-Jurgen Bigus
  • Patent number: 9389212
    Abstract: One example includes a sensor for sensing NOX, including an electrically insulating substrate, a first electrode and a second electrode, each disposed onto the substrate, wherein each of the first electrode and the second electrode has a first end configured to receive a current and a second end and a sensor element formed of nickel oxide powder, the sensor element disposed on the substrate in electrical communication with the second ends of the first electrode and the second electrode. In some examples, electronics are used to measure the change in electrical resistance of a sensor in association with NOx concentration near the sensor. In some examples, the sensor is maintained at 575° C.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: July 12, 2016
    Assignee: Honeywell International Inc.
    Inventors: Tripathy Sanjeeb, Abhilasha Srivastava, Raju Raghurama, Reddappa Reddy Kumbarageri, Srinivas S. N. Mutukuri
  • Patent number: 9389213
    Abstract: The invention relates to a tablet test station, including at least one receptacle for the transfer of tablets from an outlet of a feed device and at least one test means for inspecting, testing and/or measuring the tablets. A lifting device (20) is provided for moving the receptacle (15) relative to the feed device (13).
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: July 12, 2016
    Assignee: PHARMATRON AG
    Inventors: Thomas Boss, Holger Herrmann
  • Patent number: 9389214
    Abstract: A soil analysis apparatus includes at least one sensor element for measuring a property of the soil; a blade assembly having at least one blade and being displaceable between a raised position and an excavation position, the at least one blade being operable to excavate the soil at a test location when the blade assembly is in the excavation position, the blade assembly being further operable to enter a sensor permitting configuration; and a first actuator operable to displace the at least one sensor element between an initial position and a sensing position along a sensor displacement path, the sensor element being proximate the soil at the test location when in the sensing position.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: July 12, 2016
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Viacheslav Adamchuk, Nandkishor Dhawale, Frédéric René-Laforest, Shiv Prasher, Antoine Pouliot
  • Patent number: 9389215
    Abstract: This invention encompasses embodiments for multi-modal integrated simultaneous measurement of various aspects of fluids contained in circulating systems such as automotive reciprocating engines and vehicle transmissions. These circulating systems perform constant internal lubrication, and heat and contaminant removal to protect the internal moving parts from the inherent friction and damage in normal operation. Most commonly this is achieved with fluids based on hydrocarbon and/or related synthetics, which, over time, can lose their protective properties, and vary in their performance or breakdown/decay due to internal and external events. Several components within the lubricant fluid can be measured and can provide insight into the efficacy of the system to perform its designed mission. The mass and level of the fluid may also be monitored on an on-going basis. Described herein is a real-time, simultaneous, integrated, multi-modal sensor system for early warning notification.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 12, 2016
    Assignee: MASTINC
    Inventors: Brian Von Herzen, Steven Van Fleet, Hamish Fallside, Randall Hall
  • Patent number: 9389216
    Abstract: Disclosed is a method for testing the setting time of a cement-based material: testing the capillary negative pressure of a non-bleeding cement-based material, with the time at which the capillary negative pressure reaches a threshold value A as the initial setting time, and/or the time at which the capillary negative pressure reaches a threshold value B as the final setting time, wherein threshold value A is 8-10 kPa, and threshold value B is 54-56 kPa.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: July 12, 2016
    Assignee: SOBUTE NEW MATERIALS CO., LTD.
    Inventors: Qian Tian, Jiaping Liu, Hang Zhang, Yujiang Wang, Fei Guo, Jianye Zhang
  • Patent number: 9389217
    Abstract: Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: July 12, 2016
    Assignee: The Trustees of Princeton University
    Inventors: Robert H. Austin, Zhaoning Yu, Jonas O. Tegenfeldt, Stephen Y. Chou, Han Cao
  • Patent number: 9389218
    Abstract: A measuring device (10) includes an analysis unit (101) that holds a fluid pool (B) of blood or serum therein, an irradiation unit (105) that irradiates fluorescent substances contained in the fluid pool (B) with excitation light, and a light receiving unit (106) that receives fluorescence generated from the fluorescent substances. An amount of the fluorescent substances contained in the blood or the serum after artificial dialysis is estimated from the intensity of the fluorescence.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: July 12, 2016
    Assignees: Sharp Kabushiki Kaisha
    Inventors: Mikihiro Yamanaka, Keita Hara, Ryoji Nagai
  • Patent number: 9389219
    Abstract: The disclosure relates to the fields of protein aggregation diseases including cancer. More specifically, it concerns a screening method for identifying compounds that inhibit or disrupt co-aggregation of one or more member proteins of a disease-related protein aggregome, in particular, a tumor-associated protein aggregome. Further, disclosed are agents and compounds identified by the screening method that can be applied to prevent or to treat protein aggregation diseases, such as cancer.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: July 12, 2016
    Assignees: Vrije Universiteit Brussel, Katholieke Universiteit Leuven, K.U. Leuven R&D
    Inventors: Joost Schymkowitz, Frederic Rousseau, Jie Xu, Frederik De Smet
  • Patent number: 9389220
    Abstract: The present disclosure relates generally to drug discovery and development and, more particularly, to in vitro assay systems and methods for selecting lead anti-cancer agents for subsequent testing in human and non-human subjects. The present disclosure allows filtering for candidate anti-cancer agents that are not inactivated by liver enzymes, are able to diffuse through cell layers, are not toxic to bone marrow cells, retain anti-cancer activity in the context of stromal support, and are effective after time-limited exposure mimicking non-hepatic clearance by kidneys and other mechanisms.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: July 12, 2016
    Assignee: The Cleveland Clinic Foundation
    Inventors: Frederic J. Reu, Sergei Vatolin
  • Patent number: 9389221
    Abstract: The present disclosure provides an automated bioprocessing device, which may comprises a processing machine, one or more removable washing cartridges. The removable washing cartridge may comprise a shell, a sample holder, a washing basin, a waste container, a reagent container, a rotation mechanism, and a poking mechanism. The processing machine may comprise a motor, which may provide power to the inserted removable washing cartridge.
    Type: Grant
    Filed: April 5, 2015
    Date of Patent: July 12, 2016
    Inventors: Feng Tian, Daniel Liang Zou, Lingyun Ji
  • Patent number: 9389222
    Abstract: This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of hyaluronic acid can be used to determine whether a patient having suffered acute kidney injury will require long-term dialysis.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: July 12, 2016
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER LEARNING
    Inventors: Kai Singbartl, John A. Kellum
  • Patent number: 9389223
    Abstract: The invention provides methods for quickly and easily screening mixed cell samples for a pharmacodynamic effect to a drug or test agent.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: July 12, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Jane Trepel, Eun Joo Chung
  • Patent number: 9389224
    Abstract: The invention relates to a method of coating beads with a biological molecule comprising: (i) coating a plurality of beads with the biological molecule; (ii) mixing the coated beads with a liquid stabilizing and/or blocking agent (iii) dispersing the coated beads still substantially surrounded by a liquid phase comprising the liquid stabilizing and/or blocking agent across a surface that is at least partially liquid permeable; (iv) drying the beads on the surface to substantially remove the liquid phase; and (v) removing the dried beads from the surface.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: July 12, 2016
    Assignee: The Binding Site Group Limited
    Inventors: Roger Budd, David Taylor
  • Patent number: 9389225
    Abstract: The invention generally relates to using magnetic particles and alternating magnet fields to separate a target analyte from a sample. In certain embodiments, methods of the invention involve contacting a sample with magnetic particles including first moieties specific for a target analyte, thereby forming target/particle complexes in the sample, flowing the sample through a channel including second moieties attached to at least one surface of the channel, applying alternating magnetic fields to the flowing sample to result in target/particle complexes being brought into proximity of the surface to bind the second moieties and unbound particles remaining free in the sample, binding the target/particle complexes to the second moieties, and washing away unbound particles and unbound analytes of the sample.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: July 12, 2016
    Assignee: DNA Electronics, Inc.
    Inventors: Sergey A. Dryga, Victor C. Esch, Richard G. Saul, Andrew F. McDowell
  • Patent number: 9389226
    Abstract: There is disclosed a method for partially derivatizing a curved surface of particles in an electrically conducting solvent, said method comprises the steps: a) bringing particles in close contact with at least one surface by using a force, b) inducing a chemical reaction on at least one part of a particle by applying an electrical potential between said at least one surface and the electrically conducting solvent, and c) further reacting said at least one part of a particle where a chemical reaction has been induced in step b) above. There is further disclosed a partially derivatized particle as well as uses of the particle. Advantages include that the method is simple and only requires a potentiostat in addition to standard laboratory equipment, is inexpensive, time-efficient, and inherently parallel.
    Type: Grant
    Filed: December 15, 2008
    Date of Patent: July 12, 2016
    Assignee: LAB-ON-A-BEAD AB
    Inventors: Sven Oscarsson, Leif Nyholm, Peter Svedlindh, Klas Gunnarsson
  • Patent number: 9389227
    Abstract: The present invention provides solid supports comprising a surface bound array of dendrons and methods for using the same.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: July 12, 2016
    Assignees: POSCO, POSTECH FOUNDATION
    Inventors: Joon Won Park, Bong Jin Hong
  • Patent number: 9389228
    Abstract: A lateral flow device for use in a mainframe or point-of-care clinical analyzer, in which the lateral flow device includes a planar support having at least one sample addition area and at least one reaction area disposed thereon. The sample addition area and reaction area are fluidly interconnected to one another and form at least one lateral fluid flow path. The lateral flow device is sized for retention within a storage cartridge of the analyzer defined by a hollow interior and having a plurality of lateral flow assay devices retained in stacked relation therein.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: July 12, 2016
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Raymond F. Jakubowicz, Randy K. Bower, Joseph J. Dambra, Zhong Ding, James E. Robinson, Dale R. Ryan, David A. Tomasso
  • Patent number: 9389229
    Abstract: Methods, compositions, systems, and devices are provided for performing and analyzing agglutination assays. In one aspect, methods for image analysis of agglutination assays are provided. In another aspects, methods for performing agglutination assays are provided. In one aspect, the methods may be used for the detection of various molecules, including viruses or antibodies against a virus. In another aspect, the methods can be used to determine effective immunization of a subject.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: July 12, 2016
    Assignee: Theranos, Inc.
    Inventors: Paul Patel, Samartha Anekal, Ian Gibbons, Elizabeth A. Holmes
  • Patent number: 9389230
    Abstract: Secreted proteins as detection markers for insect vector and graft transmitted citrus disease are described. Method and kits for detecting the secreted proteins are provided.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: July 12, 2016
    Assignee: The Regents of the University of California
    Inventors: Wenbo Ma, Georgios Vidalakis
  • Patent number: 9389231
    Abstract: The present invention, in part, relates to an apparatus having a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. In some examples, the valve is opened by bringing a magnet in proximity to the valve element to provide a magnetic force that delaminates the valve element from the adhesive coating. In particular, the apparatus can be useful for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: July 12, 2016
    Assignee: Sandia Corporation
    Inventors: Thayne L. Edwards, Jason C. Harper
  • Patent number: 9389232
    Abstract: This document provides methods and materials related to polypeptides present in a vaccinia virus (e.g., polypeptides that can be isolated from naturally processed and presented class I polypeptides originating from vaccinia virus, a member of the Orthopoxvirus family). For example, methods for generating a vaccine comprising one or more of vaccinia virus polypeptides disclosed herein for preventing or treating Orthopoxvirus infection are provided. In addition, kits related to the use of vaccinia polypeptides are provided.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: July 12, 2016
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Gregory A. Poland, Inna G. Ovsyannikova, Kenneth Lee Johnson
  • Patent number: 9389233
    Abstract: The present invention concerns an in vitro method for diagnosing a myeloid tumor or a lymphoid tumor in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO:2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumor or a lymphoid tumor.
    Type: Grant
    Filed: June 12, 2009
    Date of Patent: July 12, 2016
    Assignees: Institute National de la Sante et de la Recherche Medicale (Inserm), Institut Gustave-Roussy, Assistance Publique-Hopitaux de Paris, Centre Henri Becquerel, Universite Paris Descartes, Universite Pierre et Marie Curie (PARIS 6), Universite Paris-Sud
    Inventors: Franck Viguie, Olivier Bernard, Michaela Fontenay, Christian Bastard, Francois Delhommeau, William Vainchenker
  • Patent number: 9389234
    Abstract: Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: July 12, 2016
    Assignee: Caris MPI, Inc.
    Inventors: Daniel D. Von Hoff, David M. Loesch, Arlet Alarcon, Robert J. Penny, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, Traci Pawlowski