Patents Issued in August 11, 2016
  • Single Walled Carbon Nanotube Polynucleotide Complexes and Methods Related Thereto
    Publication number: 20160228544
    Abstract: The present invention provides single-walled carbon nanotube formulations for the delivery of bioactive agents including large polynucleotides encoding therapeutic proteins into hard-to-transfect cells and methods of making such single-walled carbon nanotube formulations.
    Type: Application
    Filed: February 11, 2016
    Publication date: August 11, 2016
    Inventor: Lynn D. Kirkpatrick
  • Methods for treating and/or limiting development of diabetes in subjects with amyotrophic lateral sclerosis
    Publication number: 20160228545
    Abstract: Methods for treating and/or limiting development of diabetes in a subject with amyotrophic lateral sclerosis (ALS) by inhibiting IgG-mediated activation of voltage-gated calcium channels (VGCCs) in cells of the subject, by one or more of removing IgG from blood of the subject, blocking IgG from activating VGCCs in the subject; or blocking VGCCs in the subject are described, as are methods for identifying ALS patients at risk of developing diabetes.
    Type: Application
    Filed: February 8, 2016
    Publication date: August 11, 2016
    Inventor: Per Olof BERGGREN
  • MODIFIED ANTIBODY COMPOSITIONS, METHODS OF MAKING AND USING THEREOF
    Publication number: 20160228546
    Abstract: The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleaved, reduced, photolysed, or otherwise modified. AAs can exhibit an activatable conformation such that the AB is more accessible to a target after, for example, removal of the MM by cleavage, reduction, or photolysis of the CM in the presence of an agent capable of cleaving, reducing, or photolysing the CM. The disclosure further provides methods of making and using such modified antibodies and activatable antibodies.
    Type: Application
    Filed: April 28, 2016
    Publication date: August 11, 2016
    Inventors: Nancy Elizabeth Stagliano, James William West, Kathryn Kamath, Paul Henry Bessette, Fred Gluck, Jason Gary Sagert, Patrick Daugherty
  • CHIMERIC ANTIGEN RECEPTOR TARGETING OF TUMOR ENDOTHELIUM
    Publication number: 20160228547
    Abstract: Disclosed are methods, protocols, and compositions of matter related to utilization of chimeric antigen receptor (CAR) expressing cells for the targeting of tumor endothelium utilizing chimeric antigen receptor expressing stem cells. In one embodiment tumor endothelium specific antigens are utilized as targets of the antigen binding domain of a CAR, which is attached to an extracellular hinge domain, a domain that transverses the T cell membrane and an intracellular domain associated with T cell signaling. Suitable antigens for the practice of the invention include TEM-1, ROBO-4, surviving, and FasL. In other aspects of the invention antigens are identified through serological analysis of recombinant cDNA expression libraries (SEREX) using plasma from a patient immunized with placental endothelial cells.
    Type: Application
    Filed: February 8, 2016
    Publication date: August 11, 2016
    Applicant: Batu Biologics, Inc.
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Boris Minev
  • NANOPARTICLE DELIVERY SYSTEM FOR TARGETED ANTI-OBESITY TREATMENT
    Publication number: 20160228548
    Abstract: A magnetic nanoparticles including a TRPV1 agonist, as well as methods of preparation and use, are described herein. A magnetically responsive pharmaceutical can include a core region having a magnetic nanoparticle (MNPs) and a TRPV1 protein agonist. Further, an exterior coating comprising a polymer can be formed around the core region. The magnetically responsive pharmaceutical can be administered to a recipient and directed to a target region using an external magnetic field.
    Type: Application
    Filed: April 19, 2016
    Publication date: August 11, 2016
    Inventors: Baskaran THYAGARAJAN, Padmamalini BASKARAN
  • Multifunctional Metal Nanoparticles Having A Polydopamine-Based Surface and Methods of Making and Using the Same
    Publication number: 20160228549
    Abstract: The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, along with methods for making and using such nanoparticles. The metallic core may be gold, silver or iron oxide and the polydopamine coating may have other substances bound to it, such as silver, targeting ligands or antibodies, or other therapeutic or imaging contrast agents. The disclosed nanoparticles can be targeted to cells for treating cancer or bacterial infections, and for use in diagnostic imaging.
    Type: Application
    Filed: April 13, 2016
    Publication date: August 11, 2016
    Inventors: Phillip B. Messersmith, Kvar C.L. Black, Ji Yi, Jose G. Rivera
  • COMPOSITIONS AND METHODS OF PROPHYLAXIS FOR CONTACT DERMATITIS
    Publication number: 20160228550
    Abstract: The present invention relates to compositions and methods for inhibiting metal exposure to tissues.
    Type: Application
    Filed: April 14, 2016
    Publication date: August 11, 2016
    Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE GENERAL HOSPITAL CORPORATION
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, Richard Rox Anderson
  • Method of Treating Disorders using a Pharmaceutical Composition of Oligopeptides
    Publication number: 20160228551
    Abstract: The present invention relates to a pharmaceutical composition of oligopeptides, preferably cyclic oligopeptides, said composition further comprising one or more lipophilic and/or amphiphilic compounds, in the presence or absence of water as the main ingredients, the use of the lipophilic and/or amphiphilic compounds for making pharmaceutical compositions of said oligopeptides, and methods of making said pharmaceutical composition.
    Type: Application
    Filed: May 16, 2012
    Publication date: August 11, 2016
    Applicant: MERCK PATENT GMBH
    Inventors: Simon Goodman, Christiane Amendt, Marcus Eber
  • ORAL COMPOSITION COMPRISING A COOLING AGENT
    Publication number: 20160228552
    Abstract: The present invention relates to a formulation comprising an endothermic cooling agent selected from the group consisting of xylitol, sorbitol, mannitol and erythritol having a heat of enthalpy between ?10 cal/g and ?100 cal/g, and one or more active agents wherein the endothermic agent is present in the formulation at an amount less than 10% w/w.
    Type: Application
    Filed: April 18, 2016
    Publication date: August 11, 2016
    Inventors: Kingsley Iyoha, Neil Campbell Muir, Robert Rhoades, Alden Rodwell, David Michael Thurgood
  • Stabilised Solid Compositions of Factor VII Polypeptides
    Publication number: 20160228553
    Abstract: The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: April 20, 2016
    Publication date: August 11, 2016
    Inventors: Michael Bech Jensen, Birthe Lykkegaard Hansen, Troels Kornfelt
  • REDUCTION OF FLAKE-LIKE AGGREGATION IN NANOPARTICULATE ACTIVE AGENT COMPOSITIONS
    Publication number: 20160228554
    Abstract: This invention is directed to reduction of flake-like aggregation in nanoparticulate compositions. Also encompassed by the invention are compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent, such as a buffer and a sugar. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm.
    Type: Application
    Filed: April 15, 2016
    Publication date: August 11, 2016
    Applicant: Alkermes Pharma Ireland Limited
    Inventors: Niels P. Ryde, Peter Snyder, Wei Liu, David M. Slifer
  • REDUCTION OF FLAKE-LIKE AGGREGATION IN NANOPARTICULATE ACTIVE AGENT COMPOSITIONS
    Publication number: 20160228555
    Abstract: This invention is directed to reduction of flake-like aggregation in nanoparticulate compositions. Also encompassed by the invention are compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent, such as a buffer and a sugar. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm.
    Type: Application
    Filed: April 15, 2016
    Publication date: August 11, 2016
    Applicant: Alkermes Pharma Ireland Limited
    Inventors: Niels P. Ryde, Peter Snyder, Wei Liu, David M. Slifer
  • Radiopaque Polymers
    Publication number: 20160228556
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.
    Type: Application
    Filed: September 5, 2014
    Publication date: August 11, 2016
    Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • PERSONAL CARE COMPOSITIONS WITH ACID FUNCTIONAL SILICONE BASED STRUCTURING AGENTS
    Publication number: 20160228557
    Abstract: The invention is directed to personal care compositions comprising an acid functionality bearing silicone neutralized in situ with at least one aminosilane or a partially hydrolyzed aminosilane. The invention provides better stability to formulation in addition to improved delivery of hydrophilic actives from the formulation.
    Type: Application
    Filed: February 8, 2016
    Publication date: August 11, 2016
    Inventors: Monjit Phukan, Anubhav Saxena, Vasuki Kaushik, Richard Anthony Presti
  • TRANSDISCAL ADMINISTRATION OF SPECIFIC INHIBITORS OF PRO-INFLAMMATORY CYTOKINES
    Publication number: 20160228558
    Abstract: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
    Type: Application
    Filed: April 15, 2016
    Publication date: August 11, 2016
    Inventors: Mohamed Attawia, Thomas M. DiMauro, Hassan Serhan, Sudhakar Kadiyala, David Urbahns, Scott Bruder
  • COMPOSITION FOR APPLICATION TO A MUCOSA COMPRISING A CELLULOSE ETHER
    Publication number: 20160228559
    Abstract: A composition designed for application to a mucosa comprises i) a tonicity-adjusting agent, ii) an aqueous liquid diluent, and iii) 0.1 to 6 weight percent of a cellulose ether having a viscosity of up to 8000 mPa·s, wherein the cellulose ether has anhydroglucose units joined by 1-4 linkages and has methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that hydroxyl groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.29 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.
    Type: Application
    Filed: September 15, 2014
    Publication date: August 11, 2016
    Inventors: Jaime Curtis-Fisk, True Rogers, Susan Jordan, Matthias Knarr, Meinolf Brackenhagen, Roland Adden
  • INJECTABLE PHARMACEUTICAL COMPOSITIONS FOR SEALING TISSUES
    Publication number: 20160228560
    Abstract: Various embodiments of a pharmaceutical composition for closing or sealing an opening or a bleeding site such as a vascular puncture site following percutaneous diagnostic or therapeutic interventional procedures or any other non-vascular conduits such fistulas formed within the organs of the body. The injectable composition includes a formulation comprised of a hemostatic compound and a bioadhesive that can be injected at a positioned adjacent to the puncture site in the vasculature, or injected into the non-vascular lumen to fill the conduit created at the puncture site. In some embodiments, the formulation also contains an analgesic agent to reduce pain at the puncture site and provide comfort to the patient. In other embodiments, the formulation contains a pro-healing agent to promote the healing process of the puncture site or the non-vascular conduit.
    Type: Application
    Filed: February 7, 2016
    Publication date: August 11, 2016
    Inventor: Thomas Q. Dinh
  • Protein-Cell Conjugate, Preparation Method and Use Thereof
    Publication number: 20160228561
    Abstract: The present invention pertains to immunology, biomedicine field, specifically relates to a protein-cell conjugate, which is characterized in that the protein and the cell are coupled via a bifunctional cross-linking agent. The present invention further relates to a preparation method and uses of the protein-cell conjugate. The protein-cell conjugate of the present invention can be used for prevention or treatment of many diseases, such as malignant tumors, infectious diseases and autoimmune diseases.
    Type: Application
    Filed: May 29, 2014
    Publication date: August 11, 2016
    Applicant: CANSBIO (BEIJING) BIOTECHNOLOGY CO., LTD.
    Inventors: Changqing Xia, Yixian Guo, Haitao Wu, Suigui Wan
  • MUTUAL PRODRUG COMPRISING SHORT CHAIN FATTY ACIDS AND ZEBULARINE OR 1'-CYANO-CYTARABINE FOR CANCER TREATMENT
    Publication number: 20160228562
    Abstract: The present invention provides mutual prodrugs comprising anti-cancer nucleosides and short chain fatty acids; methods for production of the mutual prodrugs; methods of treatment comprising administration of the mutual prodrugs; and pharmaceutical compositions comprising the mutual prodrugs. Further, the mutual prodrugs of the present invention can be used as therapeutic agents for the treatment of cancer diseases and conditions.
    Type: Application
    Filed: November 14, 2014
    Publication date: August 11, 2016
    Inventors: Sunmi SHIN, Hyangmi KIM, Su-Sung OH
  • LIPIDATED PEPTIDES FOR LOWERING BLOOD GLUCOSE
    Publication number: 20160228563
    Abstract: Lipidated analogs of prolactin-releasing peptides (PrRP) and their use in controlling and lowering blood glucose in mammals is disclosed. Useful compounds included lipidated analogs of PrRP20 and PrRP31. Pharmacological effects are demonstrated both in vitro and in vivo. Peripheral administration of the lipidated peptides towers blood glucose levels. These treatments are applicable for treating impaired glucose tolerance (IGT), and glucose intolerance condition. The disclosed compounds have application in treating medical conditions including diabetes, pre-diabetes, eating disorders, and obesity.
    Type: Application
    Filed: April 26, 2016
    Publication date: August 11, 2016
    Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR, V.V.I., FYZIOLOGICKY USTAV AKADEMIE VED CR, V.V.I.
    Inventors: LENKA MALETINSKA, Blanka Zelezna, Jaroslav Kunes, Veronika Prazienkova
  • Phospholipid Ether Analogs as Cancer-Targeting Drug Vehicles
    Publication number: 20160228564
    Abstract: The present invention is directed to therapeutic compounds capable of targeting cancer cells and cancer stem cells. The present invention is further directed to compositions comprising these therapeutic compounds and methods of treating cancer comprising administering these therapeutic compounds.
    Type: Application
    Filed: April 15, 2016
    Publication date: August 11, 2016
    Inventors: Jamey P. Weichert, Anatoly Pinchuk, Kevin Kozak, Marc Longino, Joseph Grudzinski, Benjamin Titz, Chorom Pak, Nathan Stehle
  • POLYAMIDE BASED PEPTIDODENDRIMER CONJUGATES
    Publication number: 20160228565
    Abstract: The present invention relates to monofunctional and bifunctional peptidodendrimer conjugates that contain a polyamide dendrimer conjugated to Herpes Simplex Virus-1 glycoprotein-derived peptides. Also disclosed are pharmaceutical compositions containing these peptidodendrimer conjugates and methods of using these peptidodendrimer conjugates (e.g., to inhibit HSV-1 viral entry and to treat or prevent HSV-1 infection).
    Type: Application
    Filed: December 22, 2015
    Publication date: August 11, 2016
    Inventors: Marcus WECK, Stefania GALDIERO, Rossella TARALLO, Thomas Patrick CARBERRY, III, Annarita FALANGA, Massimiliano GALDIERO
  • CARRIER NANOPARTICLES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS
    Publication number: 20160228566
    Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.
    Type: Application
    Filed: April 25, 2016
    Publication date: August 11, 2016
    Inventors: MARK E. DAVIS, AKINLEYE ALABI
  • Hypoxia-Targeted Delivery System for Pharmaceutical Agents
    Publication number: 20160228567
    Abstract: Molecular compositions, nanoparticle compositions, and pharmaceutical compositions of the invention provide for the delivery of a polynucleotide to a hypoxic cell or tissue. The compositions can also be used for the delivery a hydrophobic pharmaceutical agent, either alone or in combination with a polynucleotide, to a hypoxic cell or tissue. Methods of making such compositions and methods of using such composition to treat a condition associated with a hypoxic cell or tissue are provided as well. Also provided are kits for use in treating a condition associated with a hypoxic cell or tissue.
    Type: Application
    Filed: October 21, 2014
    Publication date: August 11, 2016
    Inventors: Vladimir TORCHILIN, Swati BISWAS, Federico PERCHE
  • VIRUS-LIKE PARTICLE CONJUGATES FOR DIAGNOSIS AND TREATMENT OF TUMORS
    Publication number: 20160228568
    Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
    Type: Application
    Filed: September 18, 2014
    Publication date: August 11, 2016
    Applicants: Aura Biosciences, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Elisabet de los Pinos, John Todd Schiller, Rhonda C. Kines, John MacDougall
  • PEPTIDE CONSTRUCTS AND WELL-DEFINED AGGREGATES THEREOF
    Publication number: 20160228569
    Abstract: This invention relates to isolated peptides, peptide mimetics and repeat units thereof, which are capable of self-assembly into nano-microparticles or microparticles, which are useful for a range of application including drug delivery.
    Type: Application
    Filed: October 15, 2014
    Publication date: August 11, 2016
    Inventor: S. Kenny ROBERTS
  • Novel Antibody And Use In Diagnosis And Therapy Of Arthropathies
    Publication number: 20160228570
    Abstract: The present invention provides a composition comprising an antibody or fragment thereof against oxidised Collagen II (CII) in which the antibody or fragment thereof is conjugated to a pharmaceutically active moiety. The invention also provides a composition comprising an antibody or fragment thereof against oxidised Collagen II (CII) and a detectable label. The invention further provides the use of such compositions in medicine, in particular for the treatment of an arthropathy, and in methods of diagnosis.
    Type: Application
    Filed: January 4, 2016
    Publication date: August 11, 2016
    Inventors: Ahuva Nissim, Yuti Chernajovsky, Bjarne Faurholm, David Perrett, Paul Winyard, Christopher Hughes, Stephen Mather, Francesco Dell'Accio
  • Anti-DLL3 antibody drug conjugates
    Publication number: 20160228571
    Abstract: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
    Type: Application
    Filed: April 21, 2016
    Publication date: August 11, 2016
    Applicant: Stemcentrx, Inc.
    Inventors: Robert A. STULL, Laura SAUNDERS, Scott J. DYLLA, Orit FOORD, David LIU, Michael TORGOV, Hui SHAO
  • Immobilised Biological Entities
    Publication number: 20160228572
    Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an anti-coagulant entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which anti-coagulant entity is covalently attached to said surface through a linker comprising a thioether.
    Type: Application
    Filed: June 6, 2013
    Publication date: August 11, 2016
    Applicant: CARMEDA AB
    Inventor: Robert Vestberg
  • LIPOSOME ENCAPSULATED AFFINITY DRUG
    Publication number: 20160228573
    Abstract: The disclosure provides a liposomal antifolate composition comprising a liposome including an interior space, a bioactive antifolate agent disposed within said interior space, a steric stabilizer attached to an exterior of the liposome, and a targeting moiety comprising a protein with specific affinity for at least one folate receptor, said targeting moiety attached to at least one of the steric stabilizer and the exterior of the liposome.
    Type: Application
    Filed: August 14, 2015
    Publication date: August 11, 2016
    Inventors: Clet NIYIKIZA, Jose VARGHESE
  • PARTICLES WITH MULTIPLE FUNCTIONALIZED SURFACE DOMAINS
    Publication number: 20160228574
    Abstract: This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides simple methods to create various particles that have multiple functionalized surface domains while allowing the use of a wide variety of diverse core structures. The multiple functionalized domains provide controllable particle binding and orientation, and controlled and sustained drug release profiles.
    Type: Application
    Filed: April 13, 2016
    Publication date: August 11, 2016
    Inventors: Omid C. Farokhzad, Carolina Salvador-Morales, Weiwei Gao, Liangfang Zhang, Juliana M. Chen, Robert S. Langer
  • NARINGENIN COMPLEXES AND METHODS OF USE THEREOF
    Publication number: 20160228575
    Abstract: The invention relates to methods of treatment of hepatitis C, dyslipidemia, insulin resistance, and inflammation, with flavonoid-sugar complexes.
    Type: Application
    Filed: March 10, 2016
    Publication date: August 11, 2016
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Yaakov NAHMIAS, Martin L. YARMUSH, Raymond T. Chung
  • PHARMACEUTICAL COMPOSITIONS COMPRISING MELOXICAM
    Publication number: 20160228576
    Abstract: Disclosed herein are compositions comprising an NSAID such as meloxicam in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of conditions such as pain.
    Type: Application
    Filed: April 18, 2016
    Publication date: August 11, 2016
    Inventor: Herriot Tabuteau
  • TRANSGENIC ANIMALS FOR IN VIVO IMAGING
    Publication number: 20160228577
    Abstract: Compositions, methods and transgenic animals for in vivo detection of ectopically expressed sodium iodide symporter (NIS) are provided.
    Type: Application
    Filed: October 15, 2014
    Publication date: August 11, 2016
    Applicant: Biogen MA Inc.
    Inventors: Ajay Verma, John William Hoppin, Roger Askew
  • COATED UP-CONVERSION NANOPARTICLES
    Publication number: 20160228578
    Abstract: The invention provides novel biocompatible upconversion nanoparticle (UCNP) that comprises a core of cubic nanocrystals (e.g., comprising ?-Na Lna, Lnb Lnc F4) and an epitaxial shell (e.g., formed from CaF2; wherein Lnb is Yb), and related methods of preparation and uses thereof.
    Type: Application
    Filed: February 17, 2016
    Publication date: August 11, 2016
    Inventors: Gang Han, Jie Shen
  • LIPID NANOPARTICLES AND USES THEREOF
    Publication number: 20160228579
    Abstract: The present invention relates to lipid-associated indocyanine green particles for enhanced functional high-resolution near-infrared fluorescence medical imaging of lymphatic vessels, lymph nodes, lymphatic abnormalities, tumors, and inflammation.
    Type: Application
    Filed: May 29, 2015
    Publication date: August 11, 2016
    Inventors: Rodney J.Y. Ho, John C. Kraft, II, Mingxin Qian
  • MIXED MICELLES
    Publication number: 20160228580
    Abstract: This disclosure is directed to mixed micelle compositions for administration of e.g., therapeutic agents or imaging agents to a subject.
    Type: Application
    Filed: February 19, 2016
    Publication date: August 11, 2016
    Inventors: Wayne R. Gombotz, Suzie Pun, Christopher Mount, Tae Hee Kim, Benjamin W. Dulken
  • MACROCYCLES, COBALT AND IRON COMPLEXES OF SAME, AND METHODS OF MAKING AND USING SAME
    Publication number: 20160228581
    Abstract: Provided are macrocyclic compounds and iron or cobalt coordinated macrocyclic compounds. The compounds can be used as MRI contrast agents. Certain compounds are redox active and can be used to assess the biological redox status of a sample.
    Type: Application
    Filed: September 12, 2014
    Publication date: August 11, 2016
    Inventors: Janet R. MORROW, Pavel B. TSITOVICH, Sarina J. DORAZIO, Abiola O. OLATUNDE, Joseph A. SPERNYAK, Patrick BURNS, Eric M. SNYDER, Christopher J. BOND
  • Pre-Saturation of the Liver and Subsequent Administration of the Contrast Agent
    Publication number: 20160228582
    Abstract: The present invention relates to an aqueous formulation for use in diagnostic detection wherein the aqueous formulation is administered prior to the administration of a fluorinated contrast agent or composition comprising a fluorinated contrast agent as well as to a method of administration. The invention further relates to the use of said aqueous formulation for the diagnostic detection of inflammatory pathological conditions using MR imaging. In addition the invention relates to a kit as well as a diagnostic kit suitable for use in diagnostic detection.
    Type: Application
    Filed: September 25, 2014
    Publication date: August 11, 2016
    Inventors: Thore Dietrich, Riad Bourayou, Eckart Fleck, Thorsten Keller, Jürgen Schmitt, Doris Röthlein
  • Process for the Preparation of Gadobenate Dimeglumine Complex in a Solid Form
    Publication number: 20160228583
    Abstract: The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.
    Type: Application
    Filed: April 15, 2016
    Publication date: August 11, 2016
    Applicant: BRACCO IMAGING S.p.A.
    Inventors: Pier Lucio ANELLI, Pierfrancesco MOROSINI, Silvia CERAGIOLI, Fulvio UGGERI, Luciano LATTUADA, Roberta FRETTA, Aurelia FERRIGATO
  • 18F -GLUTATHIONE CONJUGATE AS A PET TRACER FOR IMAGING TUMORS OR NEUROLOGICAL DISORDERS THAT OVEREXPRESS L-PGDS ENZYME
    Publication number: 20160228584
    Abstract: A PET tracer for imaging tumors or neurological disorders that overexpress L-PGDS enzyme is provided. The present invention have prepared a glutathione conjugate of fluorine-18-labeled fluorobutyl ethacrynic amide using an acceptable amount of radioactivity that is capable of binding to L-PGDS and can be used for in vitro and in vivo imaging studies.
    Type: Application
    Filed: December 2, 2015
    Publication date: August 11, 2016
    Inventors: Kun-Ju LIN, Chun-Nan YEH, Ying-Cheng HUANG, Ho-Lien HUANG, Chung-Shan YU
  • Formulation, Apparatus and Method for Stabilizing Radiopharmaceuticals
    Publication number: 20160228585
    Abstract: A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.
    Type: Application
    Filed: April 20, 2016
    Publication date: August 11, 2016
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Vani P. Mocharla, Fanrong Mu, Umesh Gangadharmath
  • Compounds and Their Use for Preparation of Tau Imaging Agents and Tau Imaging Formulations
    Publication number: 20160228586
    Abstract: The present invention provides novel trimethylammonium compounds, of the Formula: (I) methods of making these compounds, methods of using the compounds for preparation of tau imaging agents, and preparation of tau imaging agent formulations.
    Type: Application
    Filed: September 19, 2014
    Publication date: August 11, 2016
    Inventors: Giorgio ATTARDO, John LISTER-JAMES, Nathaniel Anthony Co LIM, Hui XIONG
  • LABELED INHIBITORS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA), THEIR USE AS IMAGING AGENTS AND PHARMACEUTICAL AGENTS FOR THE TREATMENT OF PROSTATE CANCER
    Publication number: 20160228587
    Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).
    Type: Application
    Filed: April 18, 2016
    Publication date: August 11, 2016
    Inventors: Matthias EDER, Klaus KOPKA, Martin SCHÄFER, Ulrike BAUDER-WÜST, Uwe HABERKORN, Michael EISENHUT, Walter MIER, Martina BENESOVA
  • ETHER AND ALKYL PHOSPHOLIPID COMPOUNDS FOR TREATING CANCER AND IMAGING AND DETECTION OF CANCER
    Publication number: 20160228588
    Abstract: Methods and compositions utilizing ether and alkyl phospholipid ether analog compounds for treating cancer and imaging, monitoring, and detecting cancer stem cells in humans.
    Type: Application
    Filed: April 15, 2016
    Publication date: August 11, 2016
    Inventors: Jamey P. Weichert, Anatoly Pinchuk, Irawati Kandela, Marc Longino, William R. Clarke
  • METHODS AND COMPOSITIONS FOR IMAGING DISORDERS USING POLYSPECIFIC AGENTS
    Publication number: 20160228589
    Abstract: The present invention provides compositions and methods for detecting and/or monitoring a disease state with polyspecific imaging agents. In a particular embodiment, provided methods may be used to assess efficacy of anti-receptor tyrosine kinase and/or anti-cancer treatments. In some embodiments, the present invention provides methods and compositions relating to polyspecific imaging agents that target neurological, tumor-associated and/or intratumoral markers. For example, the present invention provides compositions, including pharmaceutical compositions, comprising anti-receptor tyrosine kinase antibodies, or fragments or characteristic portions thereof. The present invention further provides various therapeutic and/or diagnostic methods of using anti-receptor tyrosine kinase antibodies and/or compositions.
    Type: Application
    Filed: September 18, 2014
    Publication date: August 11, 2016
    Inventors: Nerissa Therese V. Villegas, Jason S. Lewis
  • System and Method for Disinfecting Medical Waste
    Publication number: 20160228590
    Abstract: The present disclosure is directed to a system and method for disinfecting medical waste. The method includes shredding the medical waste via a shredder until the medical waste has a predetermined particle size. Further steps include spreading the medical waste onto a heating conveyor and conveying the shredded medical waste through a heating chamber via a heating conveyor. Thus, within the heating chamber, the shredded medical waste is heated via one or more infrared heating elements and at least one additional heating source, e.g. induction heating, such that the medical waste is heated from a plurality of directions. The resulting treated medical waste is biologically inert and clean and can be disposed of in standard commercial garbage or roll-off bins, which are typically located at medical facilities.
    Type: Application
    Filed: February 9, 2015
    Publication date: August 11, 2016
    Inventors: Eugene W. Waldenmaier, H. Eugene W. Waldenmaier, Michael W. Green
  • COMBINATION ELECTRONIC DEVICE DOCK AND DISSINFECTOR
    Publication number: 20160228591
    Abstract: Disclosed is a disinfecting station for at least one portable electronic device. An enclosure is adapted to receive the at least one portable electronic device therein through an openable side that includes a selectively closable door. Each electronic device is exposed to a disinfecting wavelength of light, such as UV light, to disinfect the surface of the device. The enclosure can include supports that minimally contact each device so that the device will be substantially exposed to the UV light. A control circuit can monitor the exposure time and level, and is programmable to activate the UV light based on pre-set criteria. The enclosures may be stacked and provide power and network connectivity to each device while docked therein.
    Type: Application
    Filed: February 9, 2016
    Publication date: August 11, 2016
    Inventors: David G. Engelhardt, William A. Saimond
  • PLASMA VAPOR CHAMBER AND ANTIMICROBIAL APPLICATIONS THEREOF
    Publication number: 20160228592
    Abstract: Exemplary apparatuses and methods of killing or deactivating bacteria are disclosed herein. An exemplary apparatus for killing or deactivating bacteria includes a plasma vapor chamber. The plasma vapor chamber has a vapor inlet for allowing a vapor into the chamber, a high voltage electrode, one or more grounding electrodes. The one or more grounding electrodes at least partially surrounding the plasma vapor chamber. The plasma vapor chamber includes an outlet for allowing fluid to flow out of the chamber. When the chamber is filled with vapor for a period of time sufficient to saturate the chamber with vapor, the high voltage electrode is energized to generate plasma throughout the chamber.
    Type: Application
    Filed: February 11, 2016
    Publication date: August 11, 2016
    Inventors: James Ferrell, Erinn R. Bogovich, Robert L. Gray, Daphne Pappas Antonakas, Tsung-Chan Tsai, Sameer Kalghatgi
  • PROCESS CHALLENGE DEVICE AND METHODS
    Publication number: 20160228593
    Abstract: A process challenge device comprising process challenge device comprising a container defining a space within the container, wherein the space can fully contain a process indicator; and at least one pressure-actuating valve associated with the container, wherein the at least one pressure-actuating valve regulates entrance of a sterilant into and exiting of a gas and/or liquid out of the space within the container, methods of using the device and a kit including the device are disclosed.
    Type: Application
    Filed: April 18, 2016
    Publication date: August 11, 2016
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Barry W. ROBOLE, William E. FOLTZ