Abstract: A device for fractionally collecting contents of exhaled air by changing the state of matter of the contents by means of the Joule-Thomson effect arising during the expansion of pressurized gas. The temperature of the exhaled air conducted in a flow channel is lowered, because of the cooling of the expanding gas, to a temperature that is suitable for condensing the contents in the exhaled air flow. This device and method provides a more efficient means by which condensate can be separated from exhaled air in comparison to conveying exhaled air along a cooling surface for the condensation of the contents, as a result of which condensation of the contents occurs only in the area of these cooling surfaces, so that several breath cycles are required for the collection of sufficient condensate for analysis.

Abstract: A method for obtaining a point-of-collection, selected quantitative indicia of an analyte on a test strip using a smartphone involves imaging a test strip on which a colorimetric reaction of a target sample has occurred due to test strip illumination by the smartphone. The smartphone includes a smartphone app and a smartphone accessory that provides an external environment-independent/internal light-free, imaging environment independent of the smartphone platform being used. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later use, and communicated to a location where practitioners can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with others, to compete in health based games, create mappings, and other applications.

Abstract: The invention relates to a heart rate measuring apparatus and a method, adapted for measuring a subject's (6) heart rate and/or heart rate variation. The heart rate measuring apparatus (1) comprises a holder (2) adapted for carrying a portion of a body part of the subject (6) lying on or resting against the holder (2), a motion sensor (4) operatively connected to the holder (2), wherein the holder (2) is adapted for being at least partly moveable in a horizontal direction relative to the ground (7), the motion sensor (4) being adapted for measuring a signal generated by a movement of the subject (6) at least partly in the horizontal direction. In this way, a reliable signal is obtained adapted for measuring the heart rate and/or heart rate variation of a subject while keeping the implementation costs low.

Abstract: Methods and devices for monitoring the position of a subject are disclosed. One such method includes sensing pressure waves generated by the subject moving on a divided bladder comprising interleaved portions, generating signals indicative of the pressure waves for each of the interleaved portions, and sending the signals to a processor. The method further includes determining the position of the subject based on the difference between the signals from each of the interleaved portions and generating a pattern for the subject. The pattern includes the presence and/or position of the subject over time. The method further includes predicting an action such as an exit of the subject from the divided bladder based on comparing a current pattern for the subject to previous patterns for the subject.

Abstract: A system for determining the posture of a person has a motion sensor (CM) with at least one axis of measurement, which is provided with fixing means (MF) for rigidly connecting said motion sensor (CM) to a user. Analysis means (AN) are also included for determining a posture of the user. The analysis means (AN) utilize: (A) joint densities of probabilities of a low-frequency component and a high-frequency component, these densities of probabilities being defined for each posture; and (B) probabilities of transition between two successive postures.

Abstract: A method of calculating an amount of exercise performed includes measuring noise based on a relative difference in displacement between a skin of a user and a sensor attached to the skin of the user, and determining a number of steps taken by the user based on the measured noise.

Abstract: A hearing aid is fitted to an individual and/or the individual is trained in hearing with the hearing aid. In a first step a stimulus signal is provided. In a second step, the stimulus is presented to the individual. In a third step, a response of the individual in regard to the stimulus is obtained. In a fourth step a hearing aid parameter is adjusted based on the response. In an alternative or additional fourth step, a further stimulus signal is selected based on the response. The second step of presenting the stimulus signal comprises the sub-steps of obtaining a first and second signal based on the stimulus signal. In a further sub-step, the first signal is processed and presented by the hearing aid. Simultaneously, in a further sub-step, the second signal is presented by a supplementary loudspeaker for improving the stimulus presentation in regard to direct sound.

Abstract: Certain embodiments of a sensor cartridge element include a sensor module, an electrode arrangement installed on the sensor module, and a delivery arrangement securely coupled to the sensor module. The sensor module includes an analysis cell and a skin piercing member. The electrode arrangement generates an electrical signal when exposed to a fluid sample collected in the analysis cell. The delivery arrangement includes a drug reservoir, a piston chamber, and a valve arrangement providing selective fluid communication between the drug reservoir and the piston chamber. Metering electronics and an actuator can manage collection of fluid samples and/or dispensing of drug doses.

Abstract: An integrated lancing test strip includes a test strip and a lancet packet coupled to the test strip. The lancet packet includes a sterility sheet enclosing a lancet to maintain the sterility of the lancet and prevent cross-contamination between the test strip and the lancet. The sterility sheet allows the lancet to be sterilized separately from the test strip. The sterility sheet gives the integrated strip a low profile, which is attractive for packaging multiple integrated strips in cassettes, drums, magazines or the like. In one form, the integrated strip is loaded in a meter that includes an adjustment mechanism that adjusts the position of the test strip relative to the skin being sampled. This allows the user to adjust the position of the test strip so as to not apply excessive pressure against skin, which could hamper bleeding from the incision in the skin.

Abstract: Disclosed are methods, apparatuses, etc. for determination and application of a unidimensional metric for assessing a patient's glycemic health. In one particular implementation, a computed metric may be used to balance short-term and long-term risks associated with a particular therapy. In another implementation, a computed unidimensional metric may be used to balance risks of hyperglycemia and hypoglycemia.

Abstract: The present invention is directed to medical articles which exhibit a color change upon exposure to an analyte of interest and to methods of detecting analytes in bodily fluid using the same.

Abstract: A blood glucose calibration system has a noninvasive sensor that attaches to a person's tissue site so as to generate multi-stream physiological data responsive to that person's blood constituents. Composite parameters, each in the form of a mathematical combination of invasive blood panel parameters, are derived from a general population and are responsive to the multi-stream physiological data. A population-based, blood glucose estimate for that person is derived from a weighted and scaled combination of these composite parameters. An individualized blood glucose estimate is then derived from the population-based blood glucose estimate and intermittent invasive test strip measurements of that particular individual.

Abstract: An automatically locking safety device, e.g., for use in a blood collection procedure, can include a housing, first and second needle covers that are at least partly received in the housing, and a needle that is at least partly received in at least one of the first and second needle covers. The needle can include a proximal tip configured for placement into a patient and a distal tip configured for placement into a blood collection vial. In some embodiments, the first and second needle covers are biased by a biasing member. In some cases, one or both of the first and second needle covers can be locked to prevent axial movement thereof after the blood collection procedure. In certain embodiments, a distal end of the device is configured to connect with a medical connector, such as a needleless IV access device.

Abstract: A lancing device includes an advance-and-eject mechanism with a positioning member for manipulating a series of interconnected lancets. The advance-and-eject mechanism includes an actuator, a control channel, a cam-and-follower mechanism, one or more axial-contact members, and one or more angular-contact members. Actuating the actuator relative to the control channel imparts rotational and axial forces on the positioning member, and the cam-and-follower mechanism selectively restricts rotational and/or axial motion of the positioning member to induce first-stage rotation, second-stage translation, third-stage rotation, and fourth-stage translation.

Abstract: The present invention discloses a system for applying antigens or other diagnostic substances to the skin of a subject for allergy testing. The system is comprised of fully contained predetermined quantities of antigenic or other testing material contained in sealed unit doses that maintain sterility and provide for precise handling and administration. Each unit dose contains an internal mechanism. The mechanism provides for piercing the laminate and comprises an internal channel for fluid communication, and may have an abrasive protrusions at the tip for piercing or abrading the skin surface to aid in generating a diagnostic response. The unit dose or doses may be housed in devices that provide for administration of the test material to the subject wherein the applicator section may contain protrusions for piercing or abrading the skin of a subject.

Abstract: Audio sounds are captured from a subject's body, e.g., using a smartphone or a worn array of microphones. Plural features are derived from the captured audio, and serve as fingerprint information. One such feature may be a time interval over which a threshold part of spectral energy in the audio is expressed. Another may be a frequency bandwidth within which a second threshold part of the spectral energy is expressed. Such fingerprint information is provided to a knowledge base that contains reference fingerprint data and associated metadata. The knowledge base matches the fingerprint with reference fingerprint data, and provides associated metadata in return—which can comprise diagnostic information related to the captured sounds. In some arrangements, an audio signal or pressure waveform stimulates the body at one location, and is sensed at another, to discern information about the intervening transmission medium. A great variety of other features and arrangements are also detailed.

Abstract: When monitoring physiological parameters (e.g., blood pressure, heart rate, etc.) of a patient, a threshold limit (30) is set (e.g., automatically or manually) and the monitored parameter is continuously compared to the threshold limit, which may be constant or may vary with time. An alarm (36) is triggered if the monitored parameter exceeds the threshold limit at any time, or if the monitored parameter has not reached a target value by the end of a predefined time period by which an administered drug or therapy should have been effective.

Abstract: The invention provides a system for evaluating a patient featuring: 1) an ECG-measuring system connected to the patient and configured to sense ECG information from the patient; 2) a data-acquisition system interfaced to a vital sign-monitoring system configured to sense vital sign information from the patient during an electro-physiology (EP) procedure; and 3) an external software system interfaced to both systems. The external software system includes a first software interface that receives ECG information measured from the patient by the ECG-measuring system, and a second software interface that receives vital sign and EP-related information from the data-acquisition system measured from the patient during an EP procedure. A database stores physiological and EP-related information measured from the patient before, during, and after the EP procedure.

Abstract: The present invention relates to methods for differentiating a blood vessel from a nonvascular tissue during a minimally invasive surgery using a device. A device may be any penetration sensor device, such as a dilator sensor device, a hollow needle sensor device, or a trocar sensor device, which penetrates the skin and subcutaneous layers to reach a target location inside the body. The penetration sensor device includes a sensor probe which can make optical measurements to determine various parameters of the tissue at the tip of the sensor probe. These parameters may include an optical signal level returned from tissue contacting the tip of the sensor probe, an oxygen saturation level of the tissue, a total hemoglobin concentration, a blood flow, and a pulse. Based on these parameters, the presence or absence of a blood vessel at the tip of the penetration sensor device can be determined while the device travels towards the target location for surgery.

Abstract: Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel.

Abstract: Techniques for providing a personal biosensor accessory attachment are disclosed. In some embodiments, a personal biosensor accessory attachment system is disclosed. In some embodiments, a personal biosensor accessory attachment system includes a biosensor for detecting a bio-signal; and a personal biosensor device that is adapted to securely hold the biosensor, in which the personal biosensor device can be adapted to be mechanically secured to a plurality of computing devices.

Abstract: A method, computer-readable storage device and apparatus for determining a regression of a medical condition are disclosed. For example, a method receives characteristics of motion information, wherein the characteristics of motion information is based upon gait information, compares the characteristics of motion information over a time period to a profile of the medical condition, wherein the profile of the medical condition comprises a plurality of signatures associated with different stages of the medical condition, determines a potential presence of the regression of the medical condition when the characteristics of motion information matches one of the plurality of signatures, and transmits a notification of the potential presence of the regression of the medical condition.

Abstract: A nuclear medicine diagnostic apparatus includes a support unit for supporting an inspection object from front, an opening for receiving a breast of the inspection object supported by the support unit, a detector ring opposed to the inspection object across a supporting surface of the support unit for detecting radiation generated from the breast, a chest mat provided around the opening formed in the support unit for supporting the chest of the inspection object, and an outer mat provided outward of the chest mat for supporting the inspection object. The chest mat is formed of a material having a greater sagging rate than the outer mat.

Abstract: An apparatus aids operation of an interventional x-ray imager during image acquisition, where the X-ray imager is configured to vary X-ray dosages depending on differences in X-ray attenuation levels across an object of interest to be imaged. The X-ray imager is further configured to assume any one of a plurality of imaging geometry positions when acquiring an image. An indication, visual, acoustic or haptic, to the operator of the X-ray imager is provided on the incurred change in X-ray dosage when changing from a current projection view to an updated projection view, while a given constant image quality is maintained throughout the different views.

Abstract: An imaging system includes a display, an x-ray based image acquisition device, a workstation, and a medical device, e.g., a catheter. The image acquisition device is configured to obtain real-time two-dimensional images of a portion of a patient's body that is disposed within the field of view of the image acquisition device. The workstation is configured to integrate and register a three-dimensional model of an anatomic structure with the two-dimensional image, and to provide the display with a real-time image of the integrated image. The catheter includes a distal portion that comprises a radiopaque material. The image acquisition device is further adapted to apply radiation at a first dosage rate that is below a second dosage rate sufficient to detect anatomic structures.

Abstract: Included are a storage unit for storing as first medical image information a three-dimensional image representing information about an inside of the subject; an image processor for generating a display image on the basis of the first medical image information and second medical image information; and a display for displaying the display image generated by the image processor. The image processor includes: a catheter position information detector for calculating a position of the balloon catheter C and detecting position information; and a balloon pressure-contact degree calculator for calculating a pressure-contact degree A of the tissues of the subject and a balloon b on the basis of the first medical image information and the position information.

Abstract: An energy application apparatus applies energy to an object. The object (2), such as a tumor which has absorbed a radioisotope tracer, defines a location (3) of radioactive material. A location detection unit detects the location with the radioactive material. An x-ray unit applies x-rays to the detected location of the object. Since the location, to which energy should be applied, includes radioactive material, this location can be accurately detected by using the location detection unit. Moreover, since the application of the x-rays can be well controlled by controlling, for example, the intensity and the energy spectrum of the x-rays, energy can be accurately applied to the accurately detected location. The overall process of applying energy to the object can therefore be performed with increased accuracy.

Abstract: A system and method for single step and motionless x-ray phase contrast imaging. In one embodiment, a system for single step x-ray imaging includes a clinical x-ray source, a first coded aperture mask, a second coded aperture mask, and a photon counting spectral detector. The first coded aperture mask is disposed between the x-ray source and an object to be imaged. The photon counting spectral detector is disposed to detect x-rays passing through the object. The second coded aperture mask is disposed between the object to be imaged and the photon counting spectral detector. The system can provide, from a single acquisition step, an absorption image, a phase image, and differential phase image.

Abstract: Disclosed are an X-ray imaging apparatus that captures one or more images of an inner part of the human body or the like, and a method for controlling the apparatus. In particular, an imaging system includes an X-ray generator which is configured to irradiate a target object with X-rays, a detector which is configured to detect X-rays which are emitted at a plurality of times and which have propagated through the target object, a driver which is configured to change a position of the X-ray generator or the detector, an image processor which is configured to generate a plurality of X-ray images from the detected X-rays and to compare the plurality of X-ray images in order to generate at least one difference image, and a controller which is configured to detect tissues which constitute the target object based on the at least one difference image.

Abstract: A structure extraction element obtains three-dimensional structure extraction data by extracting a tubular structure from volume data obtained by imaging a predetermined subject. A relating element relates positions on paths of a two-dimensional template representing a schematic diagram of a three-dimensionally branching tubular structure obtained by imaging a predetermined subject and positions on paths of the three-dimensional structure extraction data to each other. A projection image generation element generates a two-dimensional projection image by projecting voxel values of the tubular structure that is present on the paths of the three-dimensional structure extraction data onto corresponding positions on the paths of the two-dimensional template.

Abstract: In a diagnostic imaging system (10), a monitor (50) monitors periodic biological cycles of the subject (14). A trigger point detector (60) detects a time (t1, t2, . . . , tn) of a common, reoccurring reference point (R1, R2, . . . , Rn) in each periodic cycle of the subject (14). A sequence selector (62) selects a sequence (64) of nominal sampling segments (Si, S2, . . . , Sn). An adjustor (70) adjusts duration of each nominal sampling segment (Si, S2, . . . , Sn) to coincide with the times of detected reference points (R1, R2, . . . , Rn). A scaling processor (72) scales each adjusted segment based on a difference in duration between the corresponding nominal (Si, S2, . . . , Sn) and adjusted sampling segments (S?i, S?2, . . . , S?n).

Abstract: An infrasonic stethoscope for monitoring physiological processes of a patient includes a microphone capable of detecting acoustic signals in the audible frequency bandwidth and in the infrasonic bandwidth (0.03 to 1000 Hertz), a body coupler attached to the body at a first opening in the microphone, a flexible tube attached to the body at a second opening in the microphone, and an earpiece attached to the flexible tube. The body coupler is capable of engagement with a patient to transmit sounds from the person, to the microphone and then to the earpiece.

Abstract: A medical imaging apparatus, such as including a processor circuit, can be used to construct a first image of a plane parallel to the surface of an ultrasonic imaging transducer, the plane corresponding to a locus at a specified depth within a first region of tissue. The apparatus can obtain information about a location of a vessel in the first image, then obtain, from a second region of tissue, imaging information corresponding to loci in planes parallel to the surface of the transducer, the planes at depths automatically determined at least in part using the obtained information about the location of the vessel in the first image. In an example, the apparatus can automatically determine an adjusted depth corresponding to the location of the vessel in the second region, and construct a second image of a plane corresponding to the adjusted depth within the tissue.

Abstract: A diagnostic device and method for assessing lesion formation by measuring temperature changes during endocardial ablation. Intracardiac echo catheter data is accurately mapped into a model maintained by a visualization, navigation, or mapping system using the position and orientation of the intracardiac echo catheter transducer within the model. For each point in the model, either a frequency shift or echo time shift is calculated from the intracardiac echo data to determine local temperature changes, and the local temperature changes are displayed within a rendering of the model for the user.

Abstract: The present application relates to an ultrasonic probe including a connector capable of applying an electrical signal to a piezoelectric material and disposed at the outside of a backing layer, and a method of manufacturing the same. The ultrasonic probe includes a piezoelectric material, a backing layer installed on the rear surface of the piezoelectric material, and a first connector installed on at least one side surface of the backing layer and electrically connected to the piezoelectric material.

Abstract: An ultrasound diagnostic adapter used when diagnosing a subject using an ultrasound probe that transmits and receives ultrasound waves, the ultrasound diagnostic adapter includes: a pad which has (i) a main surface that is a surface on a side where the ultrasound probe is disposed, and (ii) a back surface that is a surface which is opposite to the main surface and is on a side where the subject is disposed; and a first reflective member which is disposed inside the pad and made from a material having a different acoustic impedance than a material included in the pad, wherein the first reflective member is disposed such that at least one of (i) a distance between the first reflective member and the main surface and (ii) a width of the first reflective member viewed from the side of the main surface varies depending on a position in the main surface.

Abstract: An intravascular ultrasound catheter may include a central lumen adapted to receive a drive shaft bearing an ultrasound transducer. The intravascular ultrasound catheter may in some instances exhibit improved flexibility. The catheter can include an inner polymeric layer, an outer polymeric layer and a spiral-cut hypotube that is positioned between the inner polymeric layer and the outer polymeric layer.

Abstract: A system and method are provided for normalizing range in an optoacoustic imaging system. In an embodiment, the system includes adjustable amplifiers and a probe having an array of transducer elements, each of the adjustable amplifiers being associated with one or more of the transducer elements. The transducer elements are acoustically coupled with a surface of a volume. The gain on the adjustable amplifiers is changed as a function of the passage of time during a predetermined period of time after a pulse of light. A sinogram is recorded by sampling the adjustably amplified plurality of transducer elements for the predetermined period of time. The sinogram is processed by substantially reversing the changing step mathematically, and storing the results in an expanded dynamic range sinogram. The expanded dynamic range sinogram provides sufficient numeric precision to permit the reversal of the changing step without materially decreasing the dynamic range of the information in the sinogram.

Abstract: An optoacoustic imaging system includes a handheld probe and first and second pulsed light sources having a common output. The first and second light sources generate pulses of light at first and second predominant wavelengths, respectively. The handheld probe includes an ultrasound transducer array having an active end located at the distal end of the handheld probe for receiving an optoacoustic return signal. A sensor measures a portion of the light transmitted along the light path. A data acquisition samples the ultrasound transducer array during a predetermined period of time after a pulse of light from the first light source and during a predetermined period of time after a pulse of light from the second light source. The sampled data is stored.

Abstract: An ultrasonic imaging system comprises a processing system and an ultrasound imaging probe that is configured to transmit ultrasound energy into a selected portion of a subject and to receive echoes therefrom and to transmit data signals representative thereof to the processing system. The system further comprises a blood pressure sensor that is configured to measure the blood pressure of the subject and to transmit data signals representative thereof to the processing system. The processing system can processes the received ultrasound data signals to generate an ultrasound image and the received blood pressure data signals to generate a blood pressure trace. The processing system can also display the ultrasound image and blood pressure trace in a display image in which portions of the ultrasound image are displayed in temporal synchrony with portions of the blood pressure trace.

Abstract: An ultrasound probe diagnosing apparatus which diagnoses an ultrasound probe having an array of a plurality of ultrasound transducing elements on the basis of how the ultrasound probe receives reflected ultrasound waves from a test object placed to face the ultrasound probe, includes a part which detects a posture of the ultrasound probe with respect to the test object by comparing reflected ultrasound signals received by at least some of the plurality of ultrasound transducing elements, and a presenting part which presents information based on the detected posture.

Abstract: A method is provided for cutting a tissue sample into sections. A blade having a first reference line is provided that extends from an attachment point of the blade to a rotation mechanism to an outermost point of the blade. Also provided is the rotation mechanism having a second reference line that extends from an axis point of the rotation mechanism to the attachment point. Further, a tissue sample is provided that remains stationary for at least a portion of a cutting process by way of a holding mechanism. By way of the rotation mechanism, the blade is caused to rotate such that a first rotation of the blade causes a first cut of the tissue sample that produces a first tissue section.

Abstract: An insertion device for taking samples within a body. The insertion device includes a trigger housing, an outer sheath assembly, a sampling device, and a resilient member. The trigger housing includes an interior channel in which the resilient member is disposed to urge the outer sheath assembly away from a proximal end of the trigger housing. The outer sheath assembly is disposed within the interior channel of the trigger housing. The outer sheath assembly includes a body and an outer sheath attached to a distal end of the body. The sampling device is removably disposed within the outer sheath assembly and the trigger housing. The sampling device may be a removable biopsy needle assembly which is used to cock the insertion device. The removable biopsy needle assembly may be removed from the insertion device and be replaced by a needle assembly for fine needle aspiration.

Abstract: The present application describes an implant system useable for positioning an implant device such as a device useful for restricting passage of ingested food into the stomach. In one embodiment, the disclosed system includes a plurality of anchors that may be coupled to tissue within the stomach, or to a tissue tunnel formed by plicating stomach wall tissue. The anchor includes a loop. During use, the implant device is inserted through the loop and expanded such that it retains its position within the loop until removed. Instruments for implanting and explanting the implant device are also described.

Abstract: A medical instrument having a shaft, at the proximal end of which a handle is arranged, wherein the shaft is rotatable about its longitudinal axis and can be secured in various positions of rotation relative to the handle via a licking mechanism. In order for a medical instrument with a shaft rotatable about its longitudinal axis to be designed in such a way that, while being easy to handle, it permits a large number of secure and positionally precise rotations of the shaft with respect to the handle, the licking mechanism is designed as a latching mechanism which has a perforated disk with recesses and latching elements, wherein the latching elements and/or the perforated disk are spring-loaded relative to each other, and at least one of the latching elements engages in a corresponding recess of the perforated disk in order to fix the shaft.

Abstract: A trajectory guide for introducing an instrument into a human or animal subject is described. A guide stem can be removed in sections without disturbing the aligned instrument. An access port portion of the trajectory guide can be left in place, without disturbing trajectory alignment, and can allow overlying skin to be sutured closed. The access port can provide infusate delivery, such as using an injection port, catheter or the like. A fiducial marker arrangement can provide easy and accurate trajectory alignment, for use with the present trajectory guide, another trajectory guide, or without any trajectory guide.

Abstract: Endoscopes, medical devices for use with endoscopes, and methods for making and using endoscopes. An example medical device for use with an endoscope is a catheter having one or more ridges formed on an outer surface thereof. The ridges may interact, for example, with the elevator of an endoscope.

Abstract: The present disclosure provides treatment of an apparatus, in embodiments a delivery device, which prevents premature gelling of any materials or precursor(s) of a pH dependent forming material, in embodiments a hydrogel, dispensed by the delivery device. The pH microenvironment near the surface of a lumen of the device, in embodiments the tip of a spray applicator through which the material to be dispensed is expelled from the device, may be controlled to prevent premature gelling.

Abstract: Embodiments are described for closing vascular access ports, such as arteriotomies, which involve placement and deployment of an expandable device configured to prevent blood flow across a subject arteriotomy while also keeping disturbance of intravascular flow to a minimum. Suitable prostheses may comprise one or more frames constructed from lengths of flexible materials, such as shape memory alloys or polymers. Such frames may be coupled to sheetlike or tube-like structures configured to spread loads, minimize thrombosis which may be related to intravascular flow, and maintain hemostasis.

Abstract: Medical devices for closing anatomical apertures, such as atrial or ventricular septal defects, are disclosed. The medical devices can include a plug body having a proximal end, a distal end, and a longitudinal axis. The plug body can include an exterior surface, an interior surface defining an interior lumen, and a seal which can be located within the interior lumen. The medical devices can also include at least one arm member extending through the plug body between the exterior surface and the interior surface of the plug body. In certain embodiments, the medical device can include a distal loop and a proximal loop extending through the plug body. In certain embodiments, the proximal loop can be smaller than the distal loop, such that a top end and a bottom end of the proximal loop can fit within a top end and a bottom end of the distal loop.