Patents Issued in September 27, 2016
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Patent number: 9452941Abstract: Pyrophoric material such as iron sulfide is frequently found in refinery equipment. When the equipment is opened to the atmosphere for maintenance, an exothermic reaction can take place that may cause injury to personnel and catastrophic damage to equipment. A process used to treat pyrophoric material uses sodium nitrite injected into a gaseous carrier stream to oxidize iron sulfides to elemental sulfur and iron oxides. The sodium nitrite solution may be buffered to a pH of about 9 with disodium phosphate or monosodium phosphate. A chemical additive that provides a quantitative measure of reaction completion may be added to the treatment solution.Type: GrantFiled: March 24, 2015Date of Patent: September 27, 2016Assignee: Refined Technologies, Inc.Inventor: Sean Sears
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Patent number: 9452942Abstract: A method and apparatus for treating water including a tank having an inlet and outlet and a water treatment material or resin within the tank. A control valve assembly having multiple, separable levels houses a water usage metering mechanism and a regeneration control mechanism, each having associated turbines. An inlet/bypass valve communicates source water with the tank inlet or directly to a system outlet. When the treatment material is exhausted, it is regenerated by actuating the bypass valve to communicate the source water with the system outlet. The turbine driven regeneration control then sequences the steps of regeneration, including opening a control valve to communicate inlet water to a venturi in order to aspirate brine solution and deliver to the tank outlet. The brine solution passes through the treatment material and is discharged through the tank inlet which is communicated to a system drain.Type: GrantFiled: August 29, 2012Date of Patent: September 27, 2016Assignee: Kinetico IncorporatedInventors: Jerome P. Kovach, Stuart L. Park, Francis A. Red, Keith E. Brown, James W. Kewley, George R. Jordan, Jr., Jimmie L. Hunt, Jr., Dale J. Spangenberg, Jr.
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Patent number: 9452943Abstract: The invention relates to an anaerobic water purification system, conversion kit and method for treating a liquid. The anaerobic water purification system according to the invention comprises: —a container for the liquid for treatment provided during use with a sludge bed; —a supply conduit operatively connected to the container for supplying the liquid for treatment; —a distribution system connected to the supply conduit for distributing the liquid over the sludge bed from above; —carrier material which is arranged during use in the container and to which anaerobic sludge material can attach; and—a gas roof arranged at or on the container and provided with a volume which can be adapted during use to the biogas production. The carrier material is preferably free-floating material. The discharge conduit for discharge of treated liquid is preferably connected to a riser pipe.Type: GrantFiled: February 7, 2013Date of Patent: September 27, 2016Assignee: Aqana B.V.Inventors: Antonius Johannes Hendrikus Hyacinthus Engelaar, Sanne Steenbrink, Alje Haan
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Patent number: 9452944Abstract: A method for manufacturing an optical element includes floating an optical element material in gas to heat the optical element material, and thereafter making first and second shaping molds contact the floating optical element material at the same time, and pressurizing the optical element material by using the first and second shaping molds.Type: GrantFiled: November 7, 2012Date of Patent: September 27, 2016Assignee: Olympus CorporationInventor: Hironori Honji
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Patent number: 9452945Abstract: An apparatus for making a glass sheet using overflow fusion down-draw process comprising an inlet assembly having an elliptic cylindrical section coupled to a transition section which is, in turn, coupled to an open end of an open channel of an isopipe, and an overflow fusion down-draw process for making glass sheet. The glass melt flow has a high surface velocity profile conducive to the formation of a glass ribbon over the surface of the weirs and the wedge side surfaces with the desired mass distribution.Type: GrantFiled: February 18, 2015Date of Patent: September 27, 2016Assignee: Corning IncorporatedInventors: Steven Michael Milillo, Randy Lee Rhoads
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Patent number: 9452946Abstract: A porous soot sheet is formed using a roll-to-roll glass soot deposition and sintering process. The soot sheet formation involves depositing glass soot particles on a deposition surface to form a supported soot layer, removing the soot layer from the deposition surface to form a soot sheet, and heating a portion of the soot sheet to locally-sinter the glass soot particles and form a porous soot part having a sintered peripheral edge.Type: GrantFiled: October 18, 2013Date of Patent: September 27, 2016Assignee: CORNING INCORPORATEDInventors: Daniel Warren Hawtof, Eric John Mozdy
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Patent number: 9452947Abstract: A furnace for heating an object in a space, including a refractory ceramic wall, a heat source, at least one metal plate coated with an adherent layer of ceramic material on one of its principal faces, the coated plate being placed between the wall and the source, the adherent layer being situated facing the source. The coated metal plate acts as a thermal barrier and improves heating efficiency of the heat source. The furnace may for example serve to bend by gravity glass sheets placed on a bending frame.Type: GrantFiled: April 6, 2010Date of Patent: September 27, 2016Assignee: SAINT-GOBAIN GLASS FRANCEInventors: Xavier Fanton, Christophe Delforge, Christophe Machura, Stephane Berard
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Patent number: 9452948Abstract: A glass sheet three stage forming station utilizes first and second upper molds and a lower mold to provide three stage forming. The glass is curved on the upper mold in the first stage but retains straight line elements transverse to the curvature. Transfer of the initially formed glass sheet from the first upper mold to the lower mold then provides the second stage of gravity forming and the glass sheet is then press formed between the second upper mold and the lower mold in the third stage which reduces optical distortion in the central viewing area of the formed glass sheet. The glass sheet is moved horizontally on the first upper mold and released onto the lower mold.Type: GrantFiled: February 6, 2014Date of Patent: September 27, 2016Assignee: GLASSTECH, INC.Inventors: Dean M. Nitschke, Jeffrey A. Grzeszczak, Ashoka G. Jinka, James P. Schnabel, Jr., David B. Nitschke
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Patent number: 9452949Abstract: The present invention relates to a composite material, particularly a composite material for ceramic tiles, stone cladding, surface tops (e.g. worktops), and the like. The composite materials are typically derived from waste products. The composite materials of the present invention are formed from a glass component and a non-glass mineral component (e.g. ceramics and/or glaze). Generally the composite materials do not require any binders (especially synthetic binders) to hold the materials together. Therefore, the composite materials and products made therefrom are typically recyclable.Type: GrantFiled: October 30, 2013Date of Patent: September 27, 2016Assignee: University of Central LancashireInventors: Alasdair Bremner, David Stuart Binns
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Patent number: 9452950Abstract: The invention concerns reflective opaque panels that can be used as facing panels or decorative panels. They consist of a substrate coated with a stack of layers comprising, in the following order, at least (i) a transparent substrate, (ii) a first chromium layer, (iii) a dielectric layer in direct contact with the first chromium layer, and (iv) a second chromium layer, in direct contact with the dielectric layer.Type: GrantFiled: June 25, 2013Date of Patent: September 27, 2016Assignee: AGC GLASS EUROPEInventor: Stijn Mahieu
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Patent number: 9452951Abstract: The invention provides a system for calcining active lime, including a precalcining furnace for receiving limestone materials to be calcined and precalcining the limestone materials, and a rotary kiln for receiving the materials containing precalcined product from the precalcining furnace, outputting the formed active lime, and at the same time supplying a first flue gas to the precalcining furnace. The calcining system further includes a precalcining furnace combustion device, which generates a second flue gas and supplies it to the precalcining furnace, such that the limestone materials are precalcined in the precalcining furnace under the action of the first flue gas and the second flue gas. In this way, the precalcining rate of the limestone materials in the precalcining furnace is significantly improved.Type: GrantFiled: February 28, 2013Date of Patent: September 27, 2016Assignees: CITIC Heavy Industries Co., Ltd., Luoyang Mining Machinery Engineering Design and Research Institute Co., Ltd.Inventors: Jisheng Wang, Kaibo Zhang, Bin Qiao, Wen Zhu, Lin Jiang
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Patent number: 9452952Abstract: A new fertilizer comprising Urea Phosphite, which is made by reacting phosphorous acid with urea. Urea Phosphite is characterized by being a liquid produced in an unprocessed reaction, and by having phosphite as a phosphorus source and urea as a nitrogen source. The reaction product may be blended with an admix and spray dried, or dissolved in water.Type: GrantFiled: February 20, 2014Date of Patent: September 27, 2016Assignee: LidoChem, Inc.Inventor: Frank William Dean
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Patent number: 9452953Abstract: Compositions, methods and systems involving nitrate compounds are disclosed and described. A method of dissolving a nitrate compound having an additive can comprise dissolving the nitrate compound to form an aqueous nitrate solution and adding a surfactant to the aqueous nitrate solution, where the surfactant disperses the additive.Type: GrantFiled: February 4, 2014Date of Patent: September 27, 2016Assignee: Dyno Nobel, Inc.Inventors: Don Cranney, Robert Bingham, Lee McKenzie
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Patent number: 9452954Abstract: The present application provides methods for decarboxylation of amino acids via imine formation with a catalyst under pressurized and superheated conditions in either a microwave or oil bath.Type: GrantFiled: March 14, 2014Date of Patent: September 27, 2016Inventors: Richard W. Morrison, Douglas Michael Jackson
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Patent number: 9452955Abstract: A process for upgrading residuum hydrocarbon feedstocks that may include: contacting a residuum hydrocarbon and hydrogen with a hydroconversion catalyst in a residuum hydroconversion reactor system; recovering an effluent from the residuum hydroconversion reactor system; separating the effluent to recover two or more hydrocarbon fractions including at least a vacuum residuum fraction and a heavy vacuum gas oil fraction; combining at least a portion of the heavy vacuum gas oil fraction and at least a portion of the vacuum residuum fraction to form a mixed heavy hydrocarbon fraction; feeding at least a portion of the mixed heavy hydrocarbon fraction to a coker; operating the coker at conditions to produce anode grade green coke and distillate hydrocarbons; recovering the distillate hydrocarbons from the coker; fractionating the distillate hydrocarbons to recover hydrocarbon fractions including a light distillates fraction, a heavy coker gas oil fraction, and a coker recycle fraction.Type: GrantFiled: February 19, 2014Date of Patent: September 27, 2016Assignee: Lummus Technology Inc.Inventors: Gary Sieli, Ahmad Faegh, Ujjal K. Mukherjee, Mario C. Baldassari, Marvin I. Greene
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Patent number: 9452956Abstract: Processes for providing an isobutane recycle stream to be recycled to a dehydrogenation zone. In some embodiments a dividing wall column is used to separate a hydrogenation effluent. The hydrogenation effluent may include olefins, or it may be fully saturated. A hydrogenation zone may include a nickel based catalyst and may fully saturate dienes and olefins, or only hydrogenate dienes.Type: GrantFiled: May 29, 2015Date of Patent: September 27, 2016Assignee: UOP LLCInventors: Andrea G. Bozzano, Vesna Havran Mueller, Bing Sun, Bipin V. Vora
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Patent number: 9452957Abstract: A process is presented for removing the fouling problems associated with the product recovery in a methanol to olefins conversion process. The process includes passing the quenched MTO process stream to a product separator, wherein an intermediate stream is generated and includes water and heavier hydrocarbons. The intermediate stream is processed to remove the buildup of heavier hydrocarbons.Type: GrantFiled: June 24, 2014Date of Patent: September 27, 2016Assignee: UOP LLCInventors: John J. Senetar, Joseph A. Montalbano, Daniel A. Kauff
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Patent number: 9452958Abstract: This invention provides a process for producing a fluoroolefin comprising reacting, in a vapor phase, a fluorinating agent and a chlorine-containing alkene or a chlorine-containing alkane in the presence of at least one catalyst selected from the group consisting of chromium oxide containing a Group 5 element and fluorinated chromium oxide containing a Group 5 element. According to the process of the present invention, the target fluoroolefin can be obtained with high starting material conversion and good selectivity.Type: GrantFiled: January 24, 2013Date of Patent: September 27, 2016Assignee: DAIKIN INDUSTRIES, LTD.Inventors: Daisuke Karube, Takehiro Chaki, Masami Nishiumi, Takashi Shibanuma, Masashi Arai
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Patent number: 9452959Abstract: The invention provides compositions and methods of using the compositions in fluorinating aryl precursors containing a leaving group replaceable by fluoride ion. The compositions include a metal ion source, a fluoride ion source, and a compound, which is an aryl precursor of the aryl fluoride, and which has a leaving group replaceable by the fluoride. Exemplary methods of the invention make use of such compositions and methods to prepare an aryl fluoride compound. In an exemplary embodiment, the fluoride ion source is a source of 18F.Type: GrantFiled: June 12, 2013Date of Patent: September 27, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: John Hartwig, Patrick Fier
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Patent number: 9452960Abstract: Described herein is a composition comprising a partially fluorinated compound selected from the group consisting of: (a) I(CF2)xCH2CF2I; (b) ICF2CH2(CF2)xCH2CF2I; (c) I(CF2)yCH?CF2; (d) CF2?CH(CF2)yCH2CF2I; and (e) CF2?CH(CF2)yCH?CF2 wherein x is an odd integer selected from 3 to 11, and y is an integer greater than 2, along with methods of making and polymerizing such compounds.Type: GrantFiled: November 27, 2013Date of Patent: September 27, 2016Assignee: 3M Innovative Properties CompanyInventors: Miguel A. Guerra, Tatsuo Fukushi, Kenneth D. Wilson
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Patent number: 9452961Abstract: The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimetylpentadecan-2-one in a multistep synthesis from 6,10-dimetylundec-5-en-2-one or 6,10-dimetylundeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product.Type: GrantFiled: December 18, 2013Date of Patent: September 27, 2016Assignee: DSM IP ASSETS B.V.Inventors: Werner Bonrath, Thomas Netscher, Jonathan Alan Medlock, René Tobias Stemmler, Johannes Tschumi, Gerardus Karel Maria Verzijl, Andreas Hendrikus Maria De Vries
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Patent number: 9452962Abstract: The present invention relates to ethers of 1,2-, 1,3- and 1,4-bis(hydroxymethyl)cyclohexanes, to the preparation of such ethers and also to the use of such ethers as fragrances and as formulation auxiliaries in fragrance-comprising preparations.Type: GrantFiled: June 28, 2012Date of Patent: September 27, 2016Assignee: BASF SEInventors: Ralf Pelzer, Roland Merten, Markus Christian Biel, Pierre Fournier
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Patent number: 9452963Abstract: Disclosed is a method for producing 1,3-butadiene and/or 3-buten-2-ol from 2,3-butanediol with high selectivity without using a radioactive substance. The method for producing 1,3-butadiene and/or 3-buten-2-ol comprises the step of dehydrating 2,3-butanediol in the presence of scandium oxide. The method enables the production of 1,3-butadiene and/or 3-buten-2-ol from 2,3-butanediol with high selectivity without using a radioactive substance.Type: GrantFiled: September 8, 2014Date of Patent: September 27, 2016Assignee: TORAY INDUSTRIES, INC.Inventors: Satoshi Sakami, Katsushige Yamada, Satoshi Sato, Hailing Duan
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Patent number: 9452964Abstract: The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.Type: GrantFiled: March 31, 2015Date of Patent: September 27, 2016Assignee: Esperion Therapeutics, Inc.Inventors: Jean-Louis H. Dasseux, Carmen D. Oniciu
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Patent number: 9452965Abstract: A process for producing phenol and/or cyclohexanone is described in which cyclohexylbenzene is contacted with an oxygen-containing gas under conditions effective to produce an oxidation effluent comprising cyclohexylbenzene hydroperoxide and at least part of cyclohexylbenzene hydroperoxide is contacted with a cleavage catalyst under conditions effective to produce a cleavage effluent containing phenol and cyclohexanone. At least one of the oxidation effluent and the cleavage effluent contains at least one phenylcyclohexanol as a by-product and the process further comprises contacting the phenylcyclohexanol with a dehydration catalyst comprising a molecular sieve of the MCM-22 family under conditions effective to convert at least part of the phenylcyclohexanol to phenylcyclohexene.Type: GrantFiled: September 13, 2013Date of Patent: September 27, 2016Assignee: ExxonMobil Chemical Patents Inc.Inventors: Jihad M. Dakka, Charles Morris Smith, Keith H. Kuechler, Christopher L. Becker, Terry E. Helton, Jason D. Davis, Edmund J. Mozeleski
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Patent number: 9452966Abstract: Methods to recover or separate cesium formate or rubidium formate or both from a mixed alkali metal formate blend are described. One method involves adding cesium sulfate or rubidium sulfate to the mixed alkali metal formate blend in order to preferentially precipitate potassium sulfate from the mixed alkali metal formate blend. Another method involves adding cesium carbonate or cesium bicarbonate or both to preferentially precipitate potassium carbonate/bicarbonate and/or other non-cesium or non-rubidium metals from the mixed alkali metal blend. Further optional steps are also described. Still one other method involves converting cesium sulfate to cesium hydroxide.Type: GrantFiled: November 21, 2014Date of Patent: September 27, 2016Assignee: Cabot CorporationInventor: Bart F. Bakke
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Patent number: 9452967Abstract: Processes for the catalytic dehydration of hydroxypropionic acid, hydroxypropionic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid derivatives, or mixtures thereof with high yield and selectivity and without significant conversion to undesired side products, such as, acetaldehyde, propanoic acid, and acetic acid, are provided.Type: GrantFiled: March 15, 2013Date of Patent: September 27, 2016Assignee: The Procter & Gamble CompanyInventors: Jane Ellen Godlewski, Janette Villalobos, Dimitris Ioannis Collias, Juan Estaban Velasquez
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Patent number: 9452968Abstract: Disclosed is a process for the separation and purification of a diacid from a fermentation broth withdrawn directly from a fermentation zone for producing the diacid, wherein the fermentation broth comprises the diacid and water, a corresponding monoacid, and a corresponding ?-hydroxyacid. The process comprises passing the fermentation broth to a filtration zone having a filtration media and filtering the fermentation broth to provide a filtered feedstock. The filtered feedstock and a desorbent stream are passed to a simulated moving bed separation zone (SMB) operating in reverse phase at effective SMB conditions. The diacid may be adipic, acid, a 6-carbon atom diacid, or dodecanedioic acid, a 12-carbon atom diacid. The process is useful in simplifying the manufacturing the manufacture of diacids produced by fermentation. Adipic acid is used as monomer for the production of nylon.Type: GrantFiled: April 22, 2015Date of Patent: September 27, 2016Assignee: OROCHEM TECHNOLOGIES, Inc.Inventors: Anil R. Oroskar, Anantha Krishna Mallia
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Patent number: 9452969Abstract: A polyorganosiloxane compound, a method of preparing the same, and a copolycarbonate resin comprising the same are disclosed. Particularly, a copolycarbonate resin, which may be applied to a variety of applications, and in particular, comprises a polyorganosiloxane compound used as an impact modifier, a modifier, or a comonomer of a copolycarbonate resin and has improved mechanical properties such as low-temperature impact strength, is disclosed.Type: GrantFiled: August 11, 2015Date of Patent: September 27, 2016Assignee: LG Chem, Ltd.Inventors: Hyong Min Bahn, Moo Ho Hong, Young Young Hwang, Min Jeong Kim, Jung Jun Park
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Patent number: 9452970Abstract: A method is described for the catalytic hydrogenation of aromatic nitro compounds with hydrogen to the corresponding amines in the presence of a supported catalyst comprising platinum. The method is characterized in that the catalyst comprising platinum has been modified with a tungsten compound and with a phosphorus compound in an oxidation state of <5. High yields and high selectivities are possible with the method.Type: GrantFiled: September 3, 2013Date of Patent: September 27, 2016Assignee: ALLESSA GMBHInventors: Doris Neumann, Joachim Ritzer
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Patent number: 9452971Abstract: A method for manufacturing 3,5-dimethyl-1-adamantanamine of the present invention comprises: (i) a step of reacting 3,5-dimethyl-1-adamantanol with an acid and nitrile in an organic solvent to obtain a reaction solution; (ii) a step of adding water to the reaction solution obtained in step (i) to obtain 1-amido-3,5-dimethyladamantane; and (iii) a step of hydrolyzing 1-amido-3,5-dimethyladamantane obtained in step (ii) in the presence of an alcohol-containing solvent and an inorganic base.Type: GrantFiled: January 16, 2014Date of Patent: September 27, 2016Assignee: MITSUBISHI GAS CHEMICAL COMPANY, INC.Inventor: Tetsuya Shimo
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Patent number: 9452972Abstract: Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel disease, and arthritis are disclosed.Type: GrantFiled: June 6, 2014Date of Patent: September 27, 2016Assignee: XenoPort, Inc.Inventors: Archana Gangakhedkar, Xuedong Dai, Noa Zerangue, Peter A. Virsik
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Patent number: 9452973Abstract: Disclosed are modulators of the human relaxin receptor 1, for example, of formula (I), wherein A, R1, and R2 are as defined herein, that are useful in treating mammalian relaxin receptor 1 mediated facets of human health, e.g., cardiovascular disease. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the disclosure, and a method for therapeutic intervention in a facet of mammalian health that is mediated by a human relaxin receptor 1.Type: GrantFiled: March 15, 2013Date of Patent: September 27, 2016Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Juan Jose Marugan, Jingbo Xiao, Marc Ferrer-Alegre, Catherine Chen, Noel Southall, Wei Zheng, Alexander Agoulnik, Irina Agoulnik
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Patent number: 9452974Abstract: Provided herein are compositions including diastereomers in substantially diastereomerically pure form and enantiomers in substantially enantiomerically pure form, and processes for preparing them and converting them to metyrosine.Type: GrantFiled: August 8, 2014Date of Patent: September 27, 2016Assignee: ATON PHARMA, INC.Inventors: Kevin John Halloran, Alex Comely, Zhengming Chen, Shyam Krishnan
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Patent number: 9452975Abstract: The present invention relates to novel biobased carbodiimides, a process for production thereof and use thereof. The biobased carbodiimides according to the invention comprise the reaction product of at least one carbodiimide and a carbon acid compound isolated or produced from renewable raw materials and having a functionality>1 and/or a hydroxy carboxylic ester having 2-24 carbon atoms.Type: GrantFiled: May 22, 2014Date of Patent: September 27, 2016Assignee: Rhein Chemie Rheinau GmbHInventors: Wilhelm Laufer, Armin Eckert, Franco Orsini, Robert Eiben
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Patent number: 9452976Abstract: This disclosure describes the molecular cloning of a pactamycin biosynthetic gene cluster from Streptomyces pactum ATCC 27456, characterization of individual genes in the gene cluster and the proteins encoded thereby as well as uses thereof. The pactamycin gene cluster is located within an 86.35 kilobases genetic locus and includes 53 open reading frames, 26 of which are considered to be the core cluster directly involved in the biosynthesis of pactamycin. The present disclosure also relates to the use of the pactamycin biosynthetic genes located within the identified gene cluster for drug design and development purposes, including the development of pactamycin analogs that are more efficacious and less toxic. Also provided are drugs and antibiotics so produced, as well as methods of their use.Type: GrantFiled: January 6, 2015Date of Patent: September 27, 2016Assignee: Oregon State UniversityInventors: Taifo Mahmud, Takuya Ito, Patricia M. Flatt, Niran Roongsawang, Norifumi Shirasaka
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Patent number: 9452977Abstract: A compound having a hypoglycemic effect is provided. The compound and a pharmaceutically acceptable salt thereof are useful for the treatment or prevention of diabetes, obesity, and the like. The compound is represented by the general formula (1): (wherein R1 and R2 are each independently a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C1 to C6 alkyl group, a C1 to C6 alkoxy group, a C1 to C6 alkylsulfanyl group, a C1 to C6 alkylsulfinyl group, a C1 to C6 alkylsulfonyl group, or a C1 to C6 alkoxy-C1 to C6 alkylsulfonyl group, and A is a substituted or unsubstituted heteroaryl group).Type: GrantFiled: December 19, 2014Date of Patent: September 27, 2016Assignees: KYORIN PHARMACEUTICAL CO., LTD., TEIJIN PHARMA LIMITEDInventors: Yasumichi Fukuda, Yoshikazu Asahina, Masanori Takadoi, Masanori Yamamoto
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Patent number: 9452978Abstract: To provide a novel compound having both a surface-activating ability and a polymerization controlling ability. A compound represented by the following general formula (1) or (2): wherein, R1 and R3 are an organic group having the hydrophile-lipophile balance (HLB) determined by Griffin's method of 3 or more. The definitions of R1, R2, R3, R4, Z, p and q are described in the Description.Type: GrantFiled: January 27, 2011Date of Patent: September 27, 2016Assignee: Mitsubishi Rayon Co., Ltd.Inventors: Tetsuya Noda, Fuminori Nakaya, Keiichi Sakashita, Yosuke Matsunaga, Taeko Oonuma, Yoshiko Irie
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Patent number: 9452979Abstract: An organic substance synthesis method according to an embodiment of the present invention is carried out using a submerged plasma device (1000), for example, and the method includes: forming a plasma through discharge in a gas including a carbon dioxide as in contact with water; and generating an organic substance including performic acid or diformyl peroxide in the water by contact between the plasma and the water.Type: GrantFiled: September 9, 2014Date of Patent: September 27, 2016Assignee: PM DIMENSIONS KABUSHIKI KAISHAInventor: Tatsuo Morita
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Patent number: 9452980Abstract: The invention relates to compounds of formula wherein R, R1, R2, X, and Y are as defined herein and to a pharmaceutically suitable acid addition salt thereof. Compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds can be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.Type: GrantFiled: December 16, 2010Date of Patent: September 27, 2016Assignee: Hoffmann-La Roche Inc.Inventors: Katrin Groebke Zbinden, Roger Norcross, Philippe Pflieger
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Patent number: 9452981Abstract: A pyroglutamic acid ester of formula (1) in which A represents a C2 to C4 alkylene group; x represents a number from 1 to 100; R? represents an aliphatic, cycloaliphatic or aromatic radical that contains at least one structural unit of formula 2, and; y represents a number from 1 to 100. The use of these pyroglutamic acid esters in quantities of 0.01 to 2% by weight for preventing the formation of gas hydrates in aqueous phases that are connected to a gaseous, liquid or solid organic phase.Type: GrantFiled: December 16, 2011Date of Patent: September 27, 2016Assignee: Clariant Produkte (Deutschland) GmbHInventors: Michael Feustel, Dirk Leinweber
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Patent number: 9452982Abstract: A method of providing a cooling effect to a product includes the incorporation into the product of at least one compound of the formula I in which m is a number between 0 and 2, X, Y and Z are selected independently from the group consisting of H, halogen, OH, Me, Et, MeO and EtO, and R1, R2 and R3together comprise at least 6 carbons, selected such that (a) (i) R1 is selected from the group consisting of H, Me, Et, isopropyl and C4-C5 branched alkyl; and (ii) R2 and R3 are independently selected from the group consisting of Me, Et, isopropyl and C4-branched alkyl; or (b) any two or all of R1, R2 and R3 together form a monocyclic, bicyclic or tricyclic radical having up to 10 carbons. The compounds confer substantial cooling effects on compositions applied to the skin or taken orally, such as toothpastes, mouthwashes, foodstuffs, beverages, confectionery, tobacco products, skin creams and ointments.Type: GrantFiled: August 14, 2006Date of Patent: September 27, 2016Assignee: Givaudan, S.A.Inventors: Karen Ann Bell, Christophe C. Galopin, Jay Patrick Slack, Lori W. Tigani
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Patent number: 9452983Abstract: Provided is a method for refining quinolinic acid, including the steps of: preparing a fermentation solution including at least one of quinolinic acid and a salt thereof; removing microbial cells from the fermentation solution; preparing an acidic composition containing at least one of quinolinic acid and a salt thereof at a saturation concentration or more by adding an acid to the fermentation solution; and recovering a crystal of least one of quinolinic acid and a salt thereof from the acidic composition.Type: GrantFiled: March 6, 2014Date of Patent: September 27, 2016Assignee: CJ CHEILJEDANG CORP.Inventors: In Sung Lee, Jae Hun Yu, Ju Un Park, Chong Ho Lee, Hideki Murata
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Patent number: 9452984Abstract: 4-Amino-3-chloro-5-fluoro-6-(substituted)picolinates are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange and hydrolysis, esterification and transition metal assisted coupling.Type: GrantFiled: June 9, 2015Date of Patent: September 27, 2016Assignee: Dow AgroSciences LLCInventors: Kim E. Arndt, James M. Renga, Yuanming Zhu, Gregory T. Whiteker, Christian T. Lowe
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Patent number: 9452985Abstract: An object of the present invention is to provide a probe for imaging a ?-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.Type: GrantFiled: September 22, 2015Date of Patent: September 27, 2016Assignee: GE Healthcare LimitedInventors: Yukitsuka Kudo, Shozo Furumoto, Nobuyuki Okamura
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Patent number: 9452986Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.Type: GrantFiled: February 4, 2015Date of Patent: September 27, 2016Assignee: AbbVie Inc.Inventors: Andrew Bogdan, Marlon D. Cowart, David A. DeGoey, Tammie K. Jinkerson, John R. Koenig, Michael E. Kort, Bo Liu, Mark A. Matulenko, Derek W. Nelson, Meena V. Patel, Hillary Peltier, Marc J. Scanio, Brian D. Wakefield
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Patent number: 9452987Abstract: A pentacyclic anion salt is provided for use thereof in electrolyte compositions. The compound has an inorganic, organic or organometallic cation M of valency m (1?m?3) and m anions corresponding to the formula (I) in which Rf is a —CFZ?Z? group in which Z? is F or a perflouroalkyl group having from 1 to 3 carbon atoms, and Z? is an H, F or Cl group, an optionally fluorinated or perfluorinated alkoxy group having from 1 to 5 carbon atoms, an optionally fluorinated or perfluorinated oxaalkoxy group having 1 to 5 carbon atoms or an optionally fluorinated or perfluorinated alkyl group having from 1 to 5 carbon atoms; Z? being other than F when Z? is F. An electrolyte composition comprises said salt in solution in a liquid solvent or a polymer solvent.Type: GrantFiled: December 1, 2014Date of Patent: September 27, 2016Inventors: Michel Armand, Sylvie Grugeon, Stephane Laruelle, Maria Bukowska, Przemyslaw Szczecinski, Wladislaw Wieczorek, Leszek Niedzicky, Bruno Scrosati, Stefania Panero, Priscilla Realle
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Patent number: 9452988Abstract: The present invention is directed to bendamustine esters and bendamustine amides and their use for the treatment of cancer.Type: GrantFiled: November 12, 2013Date of Patent: September 27, 2016Assignee: Ignyta, Inc.Inventors: Roger P. Bakale, Peter D. Brown, Jian Chen, Anthony S. Drager, Rachel Y. Labell, Robert E. McKean, Piyush R. Patel, Renee C. Roemmele, Bradley McIntyre
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Patent number: 9452989Abstract: Methods, compositions, and systems for detecting gamma radiation is disclosed and described. A compound for detecting gamma radiation can comprise a conjugated imidazole having the following structure: [Formula I] where at least one of R1, R2, and R3 are conjugated organic groups. Additionally, the conjugated imidazole can be capable of reacting with a radical or ion formed by the reaction of gamma radiation with a radical generating component such as a halogen solvent to decrease a molar extinction coefficient of the conjugated imidazole in the visible light region or to quench fluorescence of the conjugated imidazole. As a sensor (100), a radiation detection indicator (108) can indicate the change in molar extinction coefficient or fluorescence of the conjugated imidazole material (120) upon exposure to gamma radiation.Type: GrantFiled: May 24, 2013Date of Patent: September 27, 2016Assignee: University of Utah Research FoundationInventors: Ling Zang, Jimin Han, Xu Miao
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Patent number: 9452990Abstract: The present invention provides a compound of formula I a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitor of the complement alternative pathway and particularly as inhibitor of Factor B for the treatment of e.g. age-related macular degeneration and diabetic retinopathy. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.Type: GrantFiled: June 19, 2013Date of Patent: September 27, 2016Assignee: NOVARTIS AGInventors: Michael Dechantsreiter, Jonathan E. Grob, Aengus Macsweeney, Wolfgang Miltz, Stefan Andreas Randl, Richard Sedrani, Holger Sellner, Finton Sirockin, Eric Valeur