Patents Issued in September 29, 2016
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Publication number: 20160279273Abstract: The invention is directed to a method for preparing a microsphere comprising a lanthanide metal phosphate complex, a microsphere, a powder comprising a number of the microspheres, a suspension comprising the microsphere or the powder, the use of the microsphere, a method for detecting a tumour, and a therapeutic composition comprising the microsphere, the powder, or the suspension. The invention provides a method for preparing a microsphere that comprises a lanthanide metal phosphate complex, the method comprising: (a) providing an organic lanthanide metal complex microsphere, wherein the lanthanide metal is present in an amount of more than 20 wt.Type: ApplicationFiled: March 31, 2016Publication date: September 29, 2016Inventors: Wouter Bult, Johannes Franciscus Wilhelmus Nijsen, Alfred Dirk van Het Schip
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Publication number: 20160279274Abstract: Disclosed herein are methods of making sterilized ciprofloxacin compositions. In some embodiments, the method includes the steps of: (a) forming an aqueous suspension comprising ciprofloxacin particles; (b) heating the aqueous suspension comprising ciprofloxacin particles at a temperature range of from about 100° C. to about 120° C.; and (c) allowing the aqueous suspension comprising ciprofloxacin particles to cool down. Also described herein are otic formulations containing ciprofloxacin formed by the disclosed methods, and therapeutic use of such otic formulation for providing sustained release of ciprofloxacin into the ear for treating various otic disorders and conditions.Type: ApplicationFiled: October 30, 2015Publication date: September 29, 2016Inventors: Scott H. Coleman, Wei-Cheng Liaw, Jerry Wroblewski, Robert Savel
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Publication number: 20160279275Abstract: A disinfection device includes a disinfection chamber into which a radiation source emits ultraviolet-C (UV-C) radiation. A radiation sensor detects the amount of UV-C radiation within the disinfection chamber, and a temperature sensor produces temperature values of a temperature within the disinfection chamber. A processing unit generates accumulated UV-C radiation values and verifies that the accumulated UV-C radiation value in the disinfection chamber reaches a first radiation threshold while also verifying that the temperature in the disinfection chamber stays below a first temperature threshold. The UV-C radiation may be emitted into the disinfection chamber over one or more fixed periods of time while the total time for the disinfection process is limited to a primary time interval. The process may terminate successfully if the first radiation threshold is exceeded before the primary time interval expires.Type: ApplicationFiled: June 2, 2016Publication date: September 29, 2016Inventors: Clément Deshays, Adrian Edward Smith, Robert Bruce Chess, Frédéric Lepine
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Publication number: 20160279276Abstract: Scent devices and methods are provided. In one embodiment, the present invention can be a device to scent an environment comprising a scent and a structural component. The scent stick can have a length to average cross-sectional diameter ratio of at least about 4:1 according to some embodiments. The scent stick can be colored to blend into an environmental setting to make the presence of the scent stick unobtrusive. The scent stick may also be attached or hung by the addition of a hanger or hoop. The scent stick may be hung from a tree, automobile mirror or a person as an adornment. Other embodiments are also described.Type: ApplicationFiled: June 10, 2016Publication date: September 29, 2016Inventor: JEFFREY S. SHERWOOD
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Publication number: 20160279277Abstract: Scent devices and methods are provided. In one embodiment, the present invention can be a device to scent an environment comprising a scent and a structural component. The scent stick can have a length to average cross-sectional diameter ratio of at least about 4:1 according to some embodiments. The scent stick can be colored to blend into an environmental setting to make the presence of the scent stick unobtrusive. The scent stick may also be attached or hung by the addition of a hanger or hoop. The scent stick may be hung from a tree, automobile mirror or a person as an adornment. Other embodiments are also described.Type: ApplicationFiled: June 10, 2016Publication date: September 29, 2016Inventor: Jeffrey S. Sherwood
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Publication number: 20160279278Abstract: A volatile composition dispenser is configured to be used in a vehicle. The volatile composition dispenser comprises a housing and a fan positioned at least partially within the housing. The fan is configured to intermittently activate to move a volume of air. The volatile composition dispenser further comprises a controller in electrical communication with the fan and positioned within the housing, and a replaceable unit configured to be attached to the housing and positioned at least partially within the housing.Type: ApplicationFiled: June 10, 2016Publication date: September 29, 2016Inventors: Dana Paul GRUENBACHER, Mark William BAIZE, Stephan Gary BUSH, Frank Peter KRESSMANN, Uwe SCHOBER
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Publication number: 20160279279Abstract: A fragrance dispenser comprises a ceramic outer shell containing a gel composition. The ceramic can be greenware, and can be impregnated with a fragrance, such as in the form of a volatile oil. The gel composition can contain fragrance or deodourisers that can diffuse out of the gel and infuse the surrounding ceramic, from which it can be released into the air. The ceramic cartridge can have indentations to allow it to be retained in a desired location; these can permit the attachment of a plastic mounting clip having a plurality of flexible arms that slot into the indentations to grip and hold the cartridge in place. This mounting clip could then be used to attach the cartridge to suitable surfaces such as a bathroom wall or the interior of a dispenser housing. Furthermore, the cartridge can have a locating recess on one or more of its sides, to receive a mounting post and thereby position the dispenser accurately and inhibit dislodgement.Type: ApplicationFiled: October 28, 2014Publication date: September 29, 2016Applicant: Vectair Systems LimitedInventors: Paul Wonnacott, Matthew Teeling
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Publication number: 20160279280Abstract: Macroporous cement compositions, methods of making the same, and methods of using the same, are described.Type: ApplicationFiled: November 21, 2014Publication date: September 29, 2016Applicant: The University of ToledoInventors: Sarit B. BHADURI, Huan ZHOU, Anand K. AGARWAL, Vijay K. GOEL, Sameh SALEH
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Publication number: 20160279281Abstract: Certain small molecule amino acid phosphate compounds such as phosphoserine and certain multivalent metal compounds such as calcium phosphate containing cements have been found to have improved properties and form an interpenetrating network in the presence of a polymer that contains either an electronegative carbonyl oxygen atom of the ester group or an electronegative nitrogen atom of the amine group as the bonding sites of the polymer surfaces to the available multivalent metal ions.Type: ApplicationFiled: December 28, 2015Publication date: September 29, 2016Inventors: Venkat R. Garigapati, Brian Hess, Cassandra L. Kimsey, Matthew E. Murphy
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Publication number: 20160279282Abstract: Embolic particles are described comprising a treated polymer particle. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer. The treated polymer particles can have a first diameter that is smaller than a second diameter, wherein the second diameter is achieved when the treated polymer particle is subjected to a physiological condition. Methods of making and using these polymer particles are also described.Type: ApplicationFiled: March 25, 2016Publication date: September 29, 2016Inventors: Gregory M. Cruise, Steve Plotkin, Xinping Wu
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Publication number: 20160279283Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: ApplicationFiled: June 10, 2016Publication date: September 29, 2016Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Publication number: 20160279284Abstract: A kit comprising a tissue dressing material for being applied in contact with the tissue of a patient and a detachment solvent for removing the tissue dressing material from the tissue. A method of treating a tissue of a patient, the method comprising the steps of: applying a water-soluble tissue dressing material in contact with the patient's tissue; and applying an acidic detachment solvent to the tissue dressing material for removing the tissue dressing material from the tissue. A method of treating a tissue of a patient, the method comprising the steps of: applying a liquid tissue dressing material in contact with the patient's tissue; and applying a detachment solvent to the tissue dressing material for removing the tissue dressing material from the tissue.Type: ApplicationFiled: June 10, 2016Publication date: September 29, 2016Inventors: Rivelino Montenegro, Thomas Freier
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Publication number: 20160279285Abstract: There is provided a composition comprising covalently linked segments of for example, polycaprolactone and polyethylene glycol that are linked by a cross-linker. Such a composition foams in the presence of a catalyst and a solution containing an oxygen forming chemical like hydrogen peroxide. The foamed composition retains oxygen for delivery to, for example, a wound, where it aids in healing.Type: ApplicationFiled: November 26, 2014Publication date: September 29, 2016Inventors: Brian J. Cuevas, Sophie Truc Lam, Nathan G. Bonn-Savage, Ramanathan S. Lalgudi, Melissa S. Roshon, Robert Jonathan Cain
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Publication number: 20160279286Abstract: The present invention describes methods and compositions of hydrogel microspheres for inducing macrophage conversion by sequentially converting a first population of wound macrophages in a wound to M2A macrophages by exposing the first population of wound macrophages to IL-4 and converting a second population of wound macrophages to M2C macrophages by exposing the second population of wound macrophages to IL-10. One aspect describes a method of inducing macrophage conversion in a wound. Another aspect describes compositions and methods of preparing a hydrogel microsphere for wound healing. Yet another aspect describes methods for treating a chronic wound with hydrogel microspheres.Type: ApplicationFiled: November 20, 2014Publication date: September 29, 2016Inventors: Kara L. SPILLER, Sina NASSIRI
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Publication number: 20160279287Abstract: The present invention relates to a flowable bone graft material including an inorganic composition comprising calcium phosphate having a particle size of about 100 ?m to about 1,000 ?m, bioactive glass, and one or more biocompatible polymers comprising carboxymethyl cellulose and a fluid.Type: ApplicationFiled: March 24, 2015Publication date: September 29, 2016Inventors: Alice Bachert, Jeremy Mercuri
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Publication number: 20160279288Abstract: Compositions and method for augmenting tissue after delivery to localized area. The compositions include a hydrogel and a dermal filler. The hydrogel can polymerize and/or crosslink upon a first trigger event. The dermal filler can also optionally crosslink upon a second trigger event.Type: ApplicationFiled: October 30, 2015Publication date: September 29, 2016Inventors: Nathaniel E. David, Jennifer H. Elisseeff
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Publication number: 20160279289Abstract: A hardenable multi-part acrylic composition comprises a solid first part and a storage stable liquid second part and optionally, further solid and/or liquid parts, the parts being operable to form a cement which hardens to a solid mass upon mixing. The composition further comprises an acrylic monomer component in the second part, an initiator component, a first sub-population of acrylic polymer particles in the first and/or further parts, a second sub-population of acrylic polymer particles in the first and/or further parts and optionally, one or more further sub-population(s) of acrylic polymer particles, and a radiopacifying filler. The initiator component amount is effective to polymerize the acrylic monomer component upon mixing. At least some of the radiopacifying filler is encapsulated within and/or adsorbed on the first sub-population of acrylic polymer particles and the second sub-population of acrylic polymer particles has a lower average particle size than the first.Type: ApplicationFiled: September 30, 2014Publication date: September 29, 2016Inventors: Michael Stephen Chisholm, Sera Saheb Abed-Ali
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Publication number: 20160279290Abstract: Provided are injectable, hyaluronic acid-based dermal filler compositions including conjugated vitamin C derivatives. The compositions provide for extended release of active vitamin C into tissue, promoting collagenesis and other benefits to skin.Type: ApplicationFiled: June 9, 2016Publication date: September 29, 2016Inventors: Futian Liu, Xiaojie Yu, Jessamine P. Winer-Jones, Nicolas J. Manesis, Hengli Liu, Gabriel Njikang, Athene Wan Chie Chan
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Publication number: 20160279291Abstract: Disclosed are a biomaterial imparted with enhanced rubber properties through natural cross-linking between collagen and hyaluronic acid, a method of preparing the same, and a method of using the same, wherein the rubber-type biomaterial is prepared from collagen and hyaluronic acid at a ratio of 2:1 to 7:1 through natural cross-linking. Specifically, a novel material that exhibits rubber properties can be prepared from collagen and hyaluronic acid at an optimal mixing ratio taking into consideration the molecular structural properties thereof under natural cross-linking conditions, rather than chemical or physical cross-linkage, thereby remarkably improving the quality and reliability of products, ultimately fulfilling various needs of consumers to thus increase marketability.Type: ApplicationFiled: November 15, 2013Publication date: September 29, 2016Inventors: Ji Chul YOO, Se Ken YEO, Myoung Sung LEE, Jun Keun LEE, Chang Kwon KO, Dong Sam SUH, Cheong Ho CHANG
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Publication number: 20160279292Abstract: Provided are layered cell sheets, comprising a plurality of layered cell sheets containing myoblasts, in which each cell sheet comprises cell population containing myoblasts with controlled orientations. Preferably provided are the layered cell sheets comprising a region in which the orientations of the cell population containing the myoblasts in each cell sheet are identical to each other.Type: ApplicationFiled: March 11, 2014Publication date: September 29, 2016Inventors: Hironobu TAKAHASHI, Tatsuya SHIMIZU, Teruo OKANO
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Publication number: 20160279293Abstract: A new preparation for regenerating tissues or healing wounds, which can be administered to a patient, which comprises serum and globin being insoluble at physiological pH, said preparation being obtained by adding said serum to said globin being insoluble at physiological pH.Type: ApplicationFiled: March 18, 2014Publication date: September 29, 2016Inventors: Jean-Louis TAYOT, Jean BERNASCONI
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Publication number: 20160279294Abstract: Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.Type: ApplicationFiled: June 6, 2016Publication date: September 29, 2016Inventors: James P. Murphy, Erik M. Erbe, Charanpreet S. Bagga, Marissa M. Conrad
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Publication number: 20160279295Abstract: Disclosed herein is a compositions-of-matter comprising a cross-linked polymer, the cross-linked polymer comprising a plurality of resilin polypeptide moieties, and at least one polymeric moiety covalently cross-linked to a plurality of the resilin polypeptide moieties via at least one cross-linking moiety, the cross-linking moiety being devoid of a biphenyl moiety. Further disclosed herein is a process for preparing the composition-of-matter, a composite material comprising the composition-of-matter and at least one additional polymeric substance bound to the cross-linked polymer, an article-of-manufacturing comprising the composition-of-matter and/or composite material, and a method of treating tissue damage or loss by implanting said article-of-manufacturing in a subject.Type: ApplicationFiled: November 5, 2014Publication date: September 29, 2016Inventors: Oded SHOSEYOV, Sigal MEIROVITCH, Shaul LAPIDOT, Amit RIVKIN
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Publication number: 20160279296Abstract: Disclosed herein are soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.Type: ApplicationFiled: June 6, 2016Publication date: September 29, 2016Inventor: Pierre F. Lebreton
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Publication number: 20160279297Abstract: The present invention relates to methods for inhibiting stenosis, obstruction, or calcification of a valve following implantation of a valve prosthesis which may involve disposing a coating composition which is a combination of two different drugs one to target inflammation and attachment of the target cell and the second drug to inhibit proliferation and calcification on an elastical stent, gortex graft or valve leaflet, the combination effect of the two drug therapies incorporated into the polymer to attach to the bioprosthesis will improve the efficacy of the inhibition of calcification and the improvement of the longevity of the prosthetic material including the stent, the valve, and the gortex covering. The valve prosthesis and or gortex graft is mounted on the elastical stent or prosthesis such that the elastical stent is in contact with the valve.Type: ApplicationFiled: October 22, 2014Publication date: September 29, 2016Applicant: Concievalve LLcInventor: Nalini M. Rajamannan
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Publication number: 20160279298Abstract: Granules useful for bone regenerative filler that exhibit enhanced cell migration and proliferation and differentiation.Type: ApplicationFiled: March 28, 2016Publication date: September 29, 2016Inventor: Daniel S. Oh
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Publication number: 20160279299Abstract: The present invention is directed to systems and/or biopolymer devices and methods of using the same. The systems and/or biopolymer devices described herein can be used for delivery of a fluid and/or molecules such as therapeutic agent(s), and/or for recruitment or collection of body fluids, e.g., for medical diagnosis. Methods of making and using the systems and/or biopolymer devices are also provided herein. In some embodiments, the systems and/or biopolymer devices can be used for continuous delivery of a therapeutic agent to repair or regenerate a tissue in a subject. In some embodiments, the biopolymer devices can be adapted for use as a catheter for fluid delivery to a target site.Type: ApplicationFiled: November 21, 2014Publication date: September 29, 2016Inventors: David L. Kaplan, Eun Seok Gil, J. Peter Rubin, Jolene E. Valentin
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Publication number: 20160279300Abstract: Elongate, flexible catheter includes a shaft having a proximal end, a distal end, and a lumen extending therein. The shaft has an inner layer comprising an amorphous polyamide having a Shore D durometer value of greater than 78, and an outer layer comprising a semi-crystalline polyamide or copolyamide having a Shore D durometer value of less than 76. The outer layer is thinner than the inner layer. The shaft has an increased resistance to kinking as compared to a similar shaft of a single layer of the amorphous polyamide having a Shore D durometer value of greater than 78.Type: ApplicationFiled: June 8, 2016Publication date: September 29, 2016Applicant: Abbott Cardiovascular Systems, Inc.Inventors: Thomas Haslinger, Jeong S. Lee, Neftali Fernandez, John A. Simpson
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Publication number: 20160279301Abstract: A hydrophilic electrospinning biological composite stent material used for tissue regeneration and a preparation method and an application thereof are provided. An aqueous solution of Fibrinogen, L-arginine or hydrochloride thereof and a P(LLA-CL) solution are blended and an electrospinning technology is used to prepare the biological composite stent material. The biological composite stent material has an equilibrium contact angle that is less than 55°, is hydrophilic and has a good application prospect in repairing body tissue defects.Type: ApplicationFiled: November 19, 2013Publication date: September 29, 2016Inventors: Hongbing HE, Ling SU, Zhang LIU, Li YANG
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Publication number: 20160279302Abstract: Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).Type: ApplicationFiled: October 30, 2015Publication date: September 29, 2016Inventors: Upma Sharma, Irina Gitlin, Gregory T. Zugates, Adam Rago, Parisa Zamiri, Ray Busold, Robert J. Caulkins, Toby Freyman, Quynh Pham, Changchen You, Jeffrey Carbeck
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Publication number: 20160279303Abstract: The invention discloses an absorbable iron alloy stent, comprising an iron alloy substrate and a degradable polymer in contact with the surface of the substrate, in which the degradable polymer has a weight average molecular weight of more than or equal to 20,000 and less than or equal to 1,000,000 and a polydispersity index of more than 1.0 and less than or equal to 50. After the iron alloy stent is implanted into the body, the degradable polymer degrades to produce a carboxyl group. After the degradable stent is implanted into the human body, the effects of oxygen-consuming corrosion enable the stent both to mainly function as a mechanical support and then to degrade gradually, and the amount of hydrogen produced in the degradation process does not reach the level that can lead to a risk of air embolism.Type: ApplicationFiled: October 31, 2014Publication date: September 29, 2016Applicant: Lifetech Scientific (Shenzhen) Co., Ltd.Inventors: Deyuan Zhang, Hongtao Sun, Liping Chen
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Publication number: 20160279304Abstract: The invention concerns polyurethane (PUR) having an antithrombogenic coating, wherein the antithrombogenic coating comprises at least one antithrombogenic substance covalently bound to a surface of the PUR via at least two bonds, wherein a first of said bonds is an amide bond between the surface of the PUR and a polyethyleneimine (PEI) and a second of said bonds is between the PEI and the antithrombogenic substance, wherein the surface of the PUR had been activated by use of a carbon dioxide plasma or a plasma modified by addition of carbon dioxide before the first of said bonds was formed.Type: ApplicationFiled: November 12, 2014Publication date: September 29, 2016Inventors: Karin Stadtherr, Christof Schmid, Karla Lehle, Karin Lukas, Hanngörg Zimmermann, Daniel Wehner, Thomas Schmid
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Publication number: 20160279305Abstract: A portable suction device comprising: a gas inlet for receiving pressurized gas from an enclosed source; a gas flow path that extends from the gas inlet to an exhaust; a suction generator that has a suction inlet, the gas flow path extending through the suction generator, such that gas flow through the flow path generates a low pressure at the suction inlet; a collection container with a collection inlet and an outlet that is coupled to the suction inlet; a suction tube that has proximal and distal ends, the proximal end being connected to the collection inlet of the collection container; a valve for controlling gas flow through the flow path, the valve having a stem that is configured to pierce the source with movement of the valve from a closed position.Type: ApplicationFiled: November 13, 2013Publication date: September 29, 2016Inventors: Philip Stuart ESNOUF, David John AULD
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Publication number: 20160279306Abstract: Wound dressing system for introduction into a wound, comprising at least one planar capillary membrane system, characterized in that the at least one planar capillary membrane system is arranged in a pouch-shaped wound dressing which is closed at its outer edge and which has an upper face, a lower face and a interior of the pouch, wherein the lower face and the upper face are each formed from a planar material, and the lower face is permeable to fluids, wherein the at least one planar capillary membrane system is arranged in the interior of the pouch and is connected to at least one supply line, such that liquids, media, gases and/or other substances can be conveyed through the supply line and the at least one capillary membrane system, and wherein the at least one supply line is connectable, outside the pouch-shaped wound dressing, to a unit for supply or disposal.Type: ApplicationFiled: November 12, 2014Publication date: September 29, 2016Applicant: 3M INNOVATIVE PROPERTIES COMPANYInventors: Carsten Meixner, Haythem Korbi
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Publication number: 20160279307Abstract: An apparatus, system, and method for treating an incisional wound having incisional walls is disclosed. The apparatus includes a conduit having a first end for receiving reduced pressure and a second end. The apparatus further includes a scaffold. The scaffold has opposing surfaces for positioning adjacent the incisional walls and is fluidly coupled to the second end of the conduit for receiving the reduced pressure. The scaffold is generally elongated in shape and has a thickness between the opposing surfaces that is sufficiently thin for positioning within the incisional wound. The apparatus further includes an internal manifold that has a primary flow channel extending generally longitudinally within the scaffold and between the opposing surfaces of the scaffold. The internal manifold is fluidly coupled to the second end of the conduit. The application of the reduced pressure through the scaffold and the internal manifold induces tissue apposition between the incisional walls.Type: ApplicationFiled: June 6, 2016Publication date: September 29, 2016Inventors: Douglas A. CORNET, Michael E. MANWARING
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Publication number: 20160279308Abstract: The device (10, 36, 38, 42, 68) applies a negative pressure to an endoluminal surface in the body of a patient to facilitate healing of a wound in the endoluminal surface. The device comprises a flexible porous element (14) with a peripheral outer face (32) for contact with the wound, the outer face being defined between opposite proximal and distal ends of the porous element. A suction tube (30) for being connected to a suction source externally of the patient's body is provided in fluid communication with the porous element to apply a negative pressure to the wound via the outer face (32) of the porous element (14) upon operation of the suction source. The porous element (14) has at least one through passageway (16) extending from its proximal end to its distal end for passage of bodily substances of the patient through the porous element.Type: ApplicationFiled: June 10, 2016Publication date: September 29, 2016Inventor: Daniel Eduard Kleiner
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Publication number: 20160279309Abstract: A catheter pump is provided that includes a rotatable impeller and an elongate cannula. The elongate cannula has a mesh that has a plurality of circumferential members disposed about the impeller. The elongate cannula has a plurality of axial connector extending between a proximal side of a distal circumferential member and a distal side of a proximal circumferential member. The circumferential members are radially self-expandable. The cannula is configured to minimize fracture within at least in the distal zone of the mesh as the elongated cannula moves into a sheathing device.Type: ApplicationFiled: June 3, 2016Publication date: September 29, 2016Inventors: Keif M. Fitzgerald, Richard L. Keenan, William J. Harrison
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Publication number: 20160279310Abstract: The present invention relates to a pump, in particular a blood pump having a proximal and a distal end and a pump housing arranged therebetween, a driveshaft arranged in an interior of the pump housing along the longitudinal direction, a conveying element arranged on the driveshaft, and a cannula. Here, the pump housing, the shaft arrangement and the conveying element are coordinated with one another in such a way that these guarantee the best possible efficiency and longevity of the pump.Type: ApplicationFiled: October 31, 2014Publication date: September 29, 2016Inventors: Mario Scheckel, Robert Decke
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Publication number: 20160279311Abstract: An axial flow blood pump having a rotor rotatably mounted in a housing. The rotor includes at least two rotor blades having different configurations.Type: ApplicationFiled: March 24, 2016Publication date: September 29, 2016Inventors: Renzo Cecere, Young Hoon Chung, Rosaire Mongrain, Toufic Azar
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Publication number: 20160279312Abstract: Devices and methods for assisting cardiac function. In an exemplary embodiment of a device for assisting heart function of the present disclosure, the device comprises a first plate and an opposing second plate, each plate having an inner surface, a cardiac processor coupled to at least one of the first plate and the second plate, a bladder having an inner chamber and disposed between the inner surfaces, and a first catheter having a proximal end in communication with the inner chamber of the bladder and a distal end having a first pericardial balloon coupled thereto, wherein a gas and/or a liquid within the inner chamber of the bladder can be injected into the first pericardial balloon upon compression of the first plate relative to the second plate, and wherein the gas and/or the liquid can be removed from the first pericardial balloon upon retraction of the first plate relative to the second plate.Type: ApplicationFiled: March 29, 2016Publication date: September 29, 2016Inventors: Ghassan S. Kassab, Jose A. Navia, SR.
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Publication number: 20160279313Abstract: A dialysis monitor with a treatment fluid path configured to provide treatment fluid to a dialyzer when dialysis treatment is performed by the dialysis monitor is provided. A battery unit is connected to a controller and at least a portion of the functional elements of the dialysis monitor in order to provide back-up power should the supply of external power be discontinued. Energy of the battery unit is used to provide energy to the heater in preparation for and/or at least partly during thermal disinfection of the treatment fluid path or when starting up the preparation of treatment fluid thereby shortening the time required for the thermal disinfection and the starting up of the preparation of treatment fluid, respectively.Type: ApplicationFiled: November 11, 2014Publication date: September 29, 2016Inventor: Sture Hobro
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Publication number: 20160279314Abstract: A system and method for the practice of apheresis employs modules in the system which can be selected for a particular patient to treat particular situations or combinations of difficulties. In one example, Gal-3 mediates a large number of body reactions, and is an effective protector of tumor microenvironments and the like, as well inflammation driver. Removal of Gal-3 may make antic-cancer treatments, like photopheresis and TNF administration more effective. Separate modules, such as one for photopheresis and one for TNF receptor removal, may be combined with a module for the reduction of Gal-3, to render the combination of treatments each more effective than if administered alone.Type: ApplicationFiled: March 28, 2016Publication date: September 29, 2016Applicant: ELIAZ THERAPEUTICS, INC.Inventor: Isaac ELIAZ
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Publication number: 20160279315Abstract: The invention relates to a device for separating blood into its components and a method for the same and use of such a device. The device comprises a magnetic drive device, which causes a container to rotate about its own axis, wherein the container has at least one open end and at least one inlet therein and is suspended in a magnetically floating manner.Type: ApplicationFiled: January 22, 2015Publication date: September 29, 2016Applicant: Fresenius Medical Care Deutschland GmbHInventor: Alexander HEIDE
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Publication number: 20160279316Abstract: A method and system for collecting a double volume of red blood cells using a spinning membrane separator is provided by which a first quantity of whole blood is withdrawn from a donor; a first quantity of whole blood is flowed to the spinning membrane separator; where it is separated into a first quantity of red blood cells and a first quantity of plasma. The first quantity of red blood cells and the first quantity of plasma are then flowed to respective collection containers, and at least a portion of the first quantity of plasma is returned to the donor. A second quantity of whole blood withdrawn from the donor, and then separated into a second quantity of red blood cells and a second quantity of plasma using the spinning membrane separator. The second quantity of red blood cells and the second quantity of plasma are then flowed to the respective collection containers, and at least a portion of the second quantity of plasma is returned to the donor.Type: ApplicationFiled: June 9, 2016Publication date: September 29, 2016Inventors: Benjamin Kusters, Kyungyoon Min, Christopher Wegener, William H. Cork
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Publication number: 20160279317Abstract: A system for providing a continuous flow of blood between two locations in a cardiovascular system of a patient is provided. The system includes a blood conduit having a proximal portion configured to be attached to an artery. The system also includes a distal portion configured to be inserted into a blood vessel at an insertion site and to be advanced there through to a location spaced apart from the insertion site. Moreover, the system includes a reinforcement member positioned at least partially about the blood conduit in at least one of the distal portion, the proximal portion, or a combination thereof.Type: ApplicationFiled: November 11, 2014Publication date: September 29, 2016Inventors: David GALE, Daniel TOMKO, Stacy ARNOLD, Venkata KATRAGADDA
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Publication number: 20160279318Abstract: Single needle vascular access systems, devices methods for use in hemodialysis and apheresis procedures the device includes a multi-layer dilator. A single needle vascular access device includes a body having a venous and arterial passage with both in fluid communication with a vascular dilator. A cannulation needle is guided through the arterial passage and vascular dilator to cannulate a graft or fistula. Following cannulation, the dilator is gently introduced into the vessel. The cannulation needle is removed, and a venous tube is introduced through the venous passageway through the vascular dilator and into the fistula or graft. Blood is then removed from the body through the vascular dilator side orifices and returned through the venous line.Type: ApplicationFiled: May 25, 2016Publication date: September 29, 2016Inventor: Eduard Tsyrulnykov
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Publication number: 20160279319Abstract: The present invention includes a comprehensive replacement fluid system and method for the delivery of regional citrate anticoagulation (RCA) to extracorporeal blood circuits, wherein the system may include an online clearance monitor (OCM) and a circuit effluent online sensor system (OSS) for the continuous determination of patient plasma content of ultrafilterable solutes.Type: ApplicationFiled: June 3, 2016Publication date: September 29, 2016Inventors: Balazs Szamosfalvi, Stanley Frinak, Jerry Yee
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Publication number: 20160279320Abstract: A medical device for separating a fluid, in particular for separating platelet-rich plasma from whole blood, includes three containers and at least one corresponding connection line having an intermediate bifurcation. Provided on the connection line are valve means for enabling or preventing a flow of fluid. At least one container includes a hollow container body and a plunger associated in a movable way to the container body. A modular structure has modules connected to enable separation thereof A first module includes at least the first container and a corresponding portion of the first connection line, and a second module, which has at least one between the second and third containers with a corresponding portion of the first connection line. Provided at least at the interface between two modules of the modular structure are releasable connectors, in particular hydraulic connectors having at least two parts that can be coupled together, each of which belongs to a corresponding module.Type: ApplicationFiled: November 13, 2014Publication date: September 29, 2016Inventors: Massimo ZANIN, Marco PIZZI, Laura MAZZUCCO, Marco BERTONI
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Publication number: 20160279321Abstract: A system for cleansing a patient's ear is disclosed. The system includes a control unit, a portable applicator, and a liquid reservoir. The liquid reservoir includes a heater. The control unit includes controls for maintaining the temperature of the liquid in the reservoir within certain limits, for limiting the pressure of the liquid, and for varying the flow rate and pressure of the liquid. The portable applicator includes a hand piece, a nozzle connected to the fluid source and mounted on the hand piece, and a trigger for providing a flow control signal to the control unit.Type: ApplicationFiled: March 11, 2016Publication date: September 29, 2016Inventors: Rohan Bansal, Joseph L. Priest, Brij Bansal, Ravinder K. Bansal
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Publication number: 20160279322Abstract: An administration device includes a container body which defines therein a chamber containing at least two substances to be administered in at least two distinct, not spontaneously emulsifiable states; a permeable fragmentation diaphragm which divides the containing chamber into a first half-chamber in which substances to be administered are loaded and a contiguous second half-chamber in which the at least two substances to be administered are mixed; a thrust member pushing at least one of the at least two substances to be administered from the first half-chamber into second half-chamber through the permeable diaphragm and pushing the at least two substances after emulsification from the second semi-chamber into a recipient; and an outlet from the second half-chamber to the recipient.Type: ApplicationFiled: March 21, 2014Publication date: September 29, 2016Applicant: NEURON GUARD S.R.L.Inventor: Enrico Giuliani