Abstract: Bust d'Odor Deodorant is a clear liquid roll-on deodorant for men and women with lemon juice and botanical extracts (honeysuckle and orange lemongrass). It is designed to remove strong underarm odor that may last up to 48 hours. There are no antiperspirants, which is the whole objective of this invention. It does not prevent sweating as do antiperspirants, because sweating is good for the human body. To prevent underarm sweat is to keep toxins or waste products in the body; and adding the chemicals in antiperspirants on top of this makes it very dangerous and unhealthy for the human body. This is a breakthrough invention for mankind, health-wise. It has no side effects except for minor itch caused by cuts from shaving. It leaves no residue or gummy, sticky feeling under armpit, and does not stain or discolor clothing.

Abstract: A formulation for the treatment of hair, in particular for treatment of hair loss and dandruff, useful as a lotion and/or a spray. The formulation comprises at least dates, date seeds, and ethanol from fermented dates and date seeds.

Abstract: Bethanechol is administered topically, for the treatment of xerostomia.

Abstract: The invention provides a sustained release intraocular drug delivery device comprising: (a) a polymeric matrix core into which at least one therapeutic agent is mixed, and; (b) a polymeric coating completely surrounding said polymeric matrix material; wherein said polymeric matrix core and polymeric coating are insoluble and inert in ocular fluids, and wherein said sustained release intraocular drug delivery device has a compliant annular segment shape and is to be inserted into the sulcus of the intact and/or pseudophakic eye.

Abstract: The subject matter of the present invention is medicinal lozenges to be sucked, having a solid consistency so as to dissolve in the oral cavity, comprising at least ibuprofen sodium dihydrate as active ingredient, which are intended for the treatment of oropharyngeal conditions.

Abstract: A method for treating type 2 diabetes in a human subject suffering from diabetes that comprises administering metformin in the period 100 to 5 minutes before a meal and subsequently consuming a protein food or protein derived drink before the meal.

Abstract: An improved polymer delivery system is described which provides polymeric microparticle compositions and porous microparticles formed therefrom. Pore size, pore architecture as well as particle size are also controllable. In some embodiments, both the polymeric microparticle compositions and porous microparticles formed therefrom encapsulate at least one substance, such as a biologic substance (one having biologic activity and/or compatible with a biologic system). The encapsulation occurs prior to polymerization. The amount of substance that is encapsulated may be controlled by the described methods. Said methods do not emply organic solvents. As such, the fabrication occurs in a solvent-free system.

Abstract: Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diameter between about 5 and about 30 microns and an aerodynamic diameter between about 1 and about 5 microns. The particles can be formed by spray-drying and are useful for delivery to the pulmonary system.

Abstract: The invention relates to a pharmaceutical tablet for oral administration comprising ulipristal acetate together with the following excipients: at least one diluent in an amount of 50 to 98.5 wt %, at least one binding agent in an amount of 0 to 10 wt %, at least one disintegrating agent in an amount of 0.5 to 10 wt %, and at least one lubricant in an amount of 0 to 10 wt %.

Abstract: The present invention relates to a slow-release solid oral nutraceutical and/or pharmaceutical composition comprising: a core containing a donor of methyl groups and at least one pharmaceutically acceptable excipient, and an outer coating containing shellac and/or a pharmaceutically acceptable salt thereof, magnesium stearate, and at least one pharmaceutically acceptable excipient. The coating of said solid oral composition allows the donor of methyl groups, preferably SAMe and/or a pharmaceutically acceptable salt thereof, to cross intact the gastric barrier and release the same in a continuous and complete manner along the entire digestive tract.

Abstract: Disclosed is a multilayer solid pharmaceutical dosage form, wherein a core containing an active ingredient is coated with a first sustained-release coating layer, a drug layer containing the active ingredient is applied onto the first layer, and a second sustained-release coating layer is applied onto the drug layer.

Abstract: The present invention relates to a multi-particulate drug delivery system, a process for its preparation and capsules being filled with such system.

Abstract: A dosage form article suitable for oral administration, comprising more than one compartments each delimited by a plurality of distinct segments selected from the group consisting of body parts, cap parts and combinations thereof. The dosage form article comprises: at least one first body part and at least one first cap part each comprising inner and outer surfaces, wherein the first body and cap parts are telescopically engageable; and at least one second body part, comprising inner and outer surfaces, being telescopically engageable with the at least one first body or cap parts or both. The at least one of the second body parts is arranged within the at least one first body part or cap part or both such that a distinct first compartment is formed between the outer surface of the second body part and the inner surface of the first body part or cap part or both.

Abstract: The invention provides a controlled release oral solid formulation comprising (a) a controlled release component comprising core comprising levodopa and/or an ester of levodopa or salts thereof, wherein the core is coated with a layer of a muco-adhesive polymer and externally coated with a layer of an enteric coated polymer; and (b) a decarboxylase inhibitor component.

Abstract: The present invention relates to immediate release soft gelatin capsules comprising 17-beta-N-[2,5-bis(trifluoromethyl)]phenylcarbamoyl-4-aza-5-alpha-androst-1-en-3-one. The invention further relates to processes for preparing such soft gelatin capsules.

Abstract: Described herein are controlled release oral pharmaceutical compositions for delivering active pharmaceutical ingredients to the colon and methods for making the same. In particular, an oral pharmaceutical composition comprising a soft capsule and a controlled release matrix for delivering active pharmaceutical ingredients to the colon are described.

Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: A flexible body comprises a polymer film having a first surface and an opposing second surface. The polymer film has a plurality of apertures extending from the first surface to the second surface and a plurality of raised lips protruding from the first surface such that each of the plurality of apertures is surrounded by one of the plurality of raised lips. A method of producing a polymer film comprises placing a polymer solution into a one sided mold having a plurality of protrusions extending from a bottom of the mold wherein the polymer solution is characterized by a viscosity that inhibits the unaided flow of the polymer throughout the mold; urging the polymer solution around each of the plurality of protrusions; and solidifying the polymer solution.

Abstract: The invention features compositions, methods, and kits for the administration of an oxidatively transformed carotenoid, or a fractionated component thereof, for use in aquaculture.

Abstract: A solution and a method by which the solution is used to treat and prevent recurrent interdigital tinea pedis (athlete's foot). The solution contains a high concentration alcohol which serves as an antifungal agent and a fragrance dissolved in the alcohol which serves as a deodorant and masks the alcohol scent in public. The solution is topically applied (e.g., sprayed) on a user's wet foot and between his toes. The alcohol in the solution evaporates to remove the moisture between the toes so as to combat the athlete's foot disease. In a preferred embodiment, the solution has a concentration of alcohol lying in a range of between 70% to 90% and a concentration of fragrance lying in a range between 0.5% to 1.0%. The remainder of the solution is ideally water.

Abstract: Beta-cryptoxanthin compositions and methods are described for the management of cardiometabolic syndrome and associated risk factors, in a subject, in need thereof. Methods herein are directed to identifying such subject at risk of developing cardiometabolic syndrome and administering beta-cryptoxanthin composition to assess the condition of an organ. Compositions and methods herein can effectively reduce risk factors of cardiometabolic syndrome, such as hyperlipidemia, insulin resistance, obesity, diabetes, atherosclerosis and/or related cardiovascular disorders. Beta-cryptoxanthin compositions and methods herein can reduce body weight, body fat, glucose levels, and free fatty acids, when administered in effective amounts. The compositions and methods herein can also reduce oxidative stress on organs such as the eye and liver and/or reduce inflammatory and/or oxidative markers, when administered to subjects in need thereof.

Abstract: The present invention relates to method(s) of treating a subject afflicted with a skin disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene or a stilbene hybrid. A method of treating or reducing the likelihood of a skin disease or condition in a patient is an additional embodiment of the present invention. Preferred pharmaceutical compositions of the invention include nanoemulsions comprising a therapeutically effective amount of a substituted cis or trans-stilbene or stilbene hybrid and at least one antibiotic.

Abstract: The present invention includes a method of treating an intervertebral disease or condition comprising: identifying a patient in need of treatment for the intervertebral disease or condition; and administering to the patient an amount of an anti-inflammatory agent that causes a cardiac channelopathy, such as curcumin, and a liposome, wherein the liposome is provided in an amount sufficient to reduce or eliminate the cardiac channelopathy caused by the anti-inflammatory agent, and the anti-inflammatory agent is provided in an amount sufficient to treat or ameliorate the symptoms of the intervertebral disease or condition.

Abstract: The present invention provides for compositions or formulations including a curcuminoid and at least one of resveratrol, resveratrol derivative, catechin, or catechin derivative. The present invention also provides for a method of treating any disease where uncontrolled cellular proliferation occurs, such as cancers. In particular, the present invention provides a method for treating cervical cancer and precancerous cervical lesions. The present invention also provides methods to treat viral infections. The disclosed compositions or formulations are biologically more active demonstrating strong synergy, functions to activate multiple novel genes. The disclosure further shows that the composition increases cellular uptake of curcumin and are able to stabilize curcumin in an aqueous environment. All these enhanced properties are accomplished by a composition or formulation that is much simpler to manufacture and lower in cost.

Abstract: The present invention provides methods of reversing the activation of hepatic stellate cells using astaxanthin (ASTX), or a pharmaceutically acceptable salt thereof, for use in the reversal of fibrosis and fibrotic diseases.

Abstract: The present application relates methods and uses of oral diamidines or pharmaceutically acceptable salts thereof for the treatment of liver diseases or conditions.

Abstract: The present invention relates to compositions comprising an alpha-adrenoceptor ligand for use in the treatment of benign anorectal conditions, in particular haemorrhoids. In addition to an alpha-adrenoceptor ligand, the compositions of the inventions may additionally include a calcium channel activator. Compositions with guanfacine and S(?)BayK8644 are preferred.

Abstract: The present invention relates CETP modulator which is useful in the prevention, treatment, delaying progression and/or reduction of eye diseases.

Abstract: Described herein are compositions and methods for intravenous administration of acetaminophen at a single dose level of less than about 1000 mg for the treatment or prevention of pain (e.g., postoperative pain) and/or fever.

Abstract: The present invention discloses and claims compositions, methods of treatment, and kits which cause an increase in the time of survival in cancer patients, wherein the cancer: (i) overexpresses thioredoxin or glutaredoxin and/or (ii) exhibits evidence of thioredoxin- or glutaredoxin-mediated resistance to one or more chemotherapeutic interventions. The present invention also discloses and claims methods and kits for the administration of said compositions to properly treat cancer patients. Additionally, the present invention discloses and claims methods and kits for quantitatively determining the level of expression of thioredoxin or glutaredoxin in the cancer cells of a cancer patient, methods of using those determined levels in the initial diagnosis and/or planning of subsequent treatment methodologies for said cancer patient, as well as ascertaining the potential growth “aggressiveness” of the particular cancer and treatment responsiveness of the particular type of cancer.

Abstract: The present invention discloses and claims compositions, methods of treatment, and kits which cause an increase in the time of survival in cancer patients, wherein the cancer: (i) overexpresses thioredoxin or glutaredoxin and/or (ii) exhibits evidence of thioredoxin- or glutaredoxin-mediated resistance to one or more chemotherapeutic interventions. The present invention also discloses and claims methods and kits for the administration of said compositions to properly treat cancer patients. Additionally, the present invention discloses and claims methods and kits for quantitatively determining the level of expression of thioredoxin or glutaredoxin in the cancer cells of a cancer patient, methods of using those determined levels in the initial diagnosis and/or planning of subsequent treatment methodologies for said cancer patient, as well as ascertaining the potential growth “aggressiveness” of the particular cancer and treatment responsiveness of the particular type of cancer.

Abstract: A modified release dosage form for the oral administration of tranexamic acid.

Abstract: The present invention relates to the field of medicine. It relates more particularly to the use of compounds to prevent and/or treat lipotoxicity in a subject, especially lipotoxicity by hypoxia. The invention relates more particularly to compositions, especially pharmaceuticals compositions and nutritional supplements or complements comprising such compounds as well as their use to prevent and/or treat lipotoxicity, especially lipotoxicity by hypoxia. The compounds and compositions of the invention can especially be advantageously used to prevent and/or treat a pathology from among pulmonary pathologies, especially cystic fibrosis or a chronic obstructive pulmonary disease.

Abstract: Provided are methods and compositions for improving kidney function and for the treatment or prophylaxis of kidney disease in dogs.

Abstract: The present invention relates to new ingenol derivative compounds for inhibiting cancer cell viability and treating cancer. In other aspects, the invention relates to a pharmaceutical composition, a medicament, methods for treating cancer, and a dosage form.

Abstract: A compound particularly for treating depression and anxiety, having the combination of at least 11-keto-beta-boswellic acid (KBA) and acetyl-11-keto-beta-boswellic acid (AKBA). Various doses of the compound are also used in particular physiopathologies.

Abstract: In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating pulmonary fibrosis comprising an isothiocyanate-based compound and a biguanide agent as active ingredients, a method for preventing or treating pulmonary fibrosis using the composition, and use of the isothiocyanate-based compound and the biguanide agent for the preparation of the prophylactic or therapeutic agent for preventing or treating pulmonary fibrosis. The pharmaceutical composition comprising the isothiocyanate-based compound and the biguanide agent as active ingredients of the present invention can be used to stably prevent or treat pulmonary fibrosis for which specific therapeutic agents have not yet been known, and thus it can be widely used for health and welfare improvement through treatment of pulmonary fibrosis.

Abstract: Disclosed herein are methods and uses for preventing melanoma, reducing progression of atypical nevi, and inducing cell cycle arrest and/or apoptosis in a melanoma cell through oral and enteral administration of sulforaphane to subjects indicated to be at risk due to factor(s) such as medical history of atypical nevi, melanoma, or UV exposure. Sulforaphane can be administered orally as a safe and well-tolerated natural agent as a chemopreventive strategy in individuals with atypical melanocytic nevi.

Abstract: The invention relates to dihydroorate dehydrogenase (DHODH) inhibitors useful for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis.

Abstract: The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.

Abstract: Since a compound represented by the general formula (I) (wherein definition of each group is as described in the specification), a salt thereof, a solvate thereof, or a prodrug thereof has strong and sustaining intraocular pressure lowering activity and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc.

Abstract: The present invention is about preparing gelatin nanoparticles having a size of about 200 nm are supported or not supported with a hardly-water soluble drug without a homogenizer by constructing O/W/O or W/O systems, thereby relatively prolonging the circulation time within the human body as compared to a water-repellent particle because it is free from the immune system, and enhancing EPR (Enhanced permeability and retention) effects. In this case, the hardly-water soluble drug includes hardly soluble anticancer agents such as paclitaxel, coenzyme Q10, ursodexoychlic acid, ilaprazole or imatinib mesylate. Furthermore, the O/W/O or W/O systems are nonpolar phase/polar phase/nonvolatile nonpolar phase and polar phase/nonvolatile nonpolar phase systems, respectively. More specifically, the O/W/O or W/O systems presents a hardly soluble drug/gelatin nanoparticle/fatty acid and gelatin nanoparticle/fatty acid systems, respectively.

Abstract: The present invention relates to an inhibitor of protein translation for use in high-dose chemotherapy and/or high-dose radiotherapy of disease; to an inhibitor of protein translation for use in a combination therapy comprising high-dose chemotherapy and/or high-dose radiotherapy of disease; and to an inhibitor of protein translation for use in preventing adverse effects of high-dose chemotherapy and/or high-dose radiotherapy or for preventing radiation syndrome in a subject.

Abstract: A cancer treatment comprises the administration of a pro-drug compound identified by an in silico candidate identification screening. The pro-drug candidates are selected from a data base and calculations are carried out on the association of the pro-drug candidates to form a complex with a metal ion and a proteasome active site. The pro-drug inhibits the active site of the proteasome in the presence of the metal ion and has little or no effect in the absence of the metal ion. The pro-drug can be: 3,4-dihydroxybenzoic acid; galloflavin; 2-{[(carbamoylsulfanyl)acetyl]amino}benzoic acid; 6,7-Dihydroxycoumaranone; 3,6-bis(hydroxymethyl)pyridazin-4(1H)-one; and 4?,5,7-trihydroxyisoflavone, for binding with copper ion and proteasome.

Abstract: Novel substituted chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.

Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.

Abstract: Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.

Abstract: The present invention broadly relates to oral dosage forms for therapeutic use in the prevention of cardiovascular and cerebrovascular diseases in mammals, preferably in humans. Particularly, the invention relates to a tablet comprising (a) one or more HMG-CoA reductase inhibitors, (b) one or 5 more antagonists of angiotensin II receptors and (c) one or more thiazide diuretics.

Abstract: The invention provides trifluoromethyl pyrazolyl guanidine compounds that inhibit F1F0-ATPase, and methods of using trifluoromethyl pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.