Abstract: A first data window of a pulse waveform signal comprising a first number of samples is analyzed to determine a level of confidence that a pulse sensing device is placed correctly. If an initial level of confidence is met, the user is given positive feedback, and a second data window of a pulse waveform signal comprising a second, larger number of samples is analyzed. If an increased level of confidence is met, the user is given increased positive feedback. If a level of confidence is not met, the user is given negative feedback. If a final level of confidence is met, the user is given feedback that the pulse sensing device is placed correctly.

Abstract: Disclosed is a system that includes pressure sensors to assist in monitoring pressure at a selected location. Pressure sensors may be applied to or incorporated into catheters and/or shunts positioned within a patient. A monitoring system may then receive signals from the pressure sensors to monitor pressure at the location over time.

Abstract: A bipolar stimulation probe including a first electrode, a second electrode, a control module, and switches. The control module is configured to stimulate nerve tissue of a patient by generating (i) a first output signal indicative of a first pulse to be output from the first electrode, and (ii) a second output signal indicative of a second pulse to be output from the second electrode. The first pulse and the second pulse are monophasic. The switches are configured to output from the bipolar stimulation probe (i) the first pulse on the first electrode based on the first output signal, and (ii) the second pulse on the second electrode based on the second output signal.

Abstract: A microelectrode (2) for neural interfacing applications comprises a first substrate layer (4), a second attachment layer (6), and a third layer (8) forming the active part of the electrode (2) of which the material consists of synthetic diamond made in electrically conductive by doping with atoms chosen from boron, nitrogen and phosphorus atoms. The material of the third layer (8) is a textured material that comprises a compact assembly, in the form of a brush, of tubes (26) each comprising, in the form of at in least one peripheral outer layer, polycrystalline diamond made electrically conductive by doping. The tubes (26) are separated from each other at the first fixed ends (28) of same and project the free ends (30) of same away from the first and second layers (4, 6) in a direction that is substantially vertical relative to the extension plane (20) of the second layer (6). A method for producing said microelectrode is also described.

Abstract: Neuromodulation systems with nerve monitoring assemblies and associated devices, systems, and methods are disclosed herein. A neuromodulation system configured in accordance with some embodiments of the present technology can include, for example, a generator, a nerve monitoring assembly configured to detect electroneurogram (ENG) signals, and a neuromodulation catheter. The neuromodulation catheter can include an elongated shaft with a distal portion and a proximal portion. The distal portion of the shaft can include an array of electrodes configured to detect nerve activity from within a blood vessel of a human. The proximal portion of the shaft can include at least one connector that operably couples the electrodes to the generator and to the nerve monitoring assembly.

Abstract: An apparatus includes a sensing circuit configured to generate a sensed physiological signal representative of cardiac activity of a subject, and an arrhythmia detection circuit. The arrhythmia detection circuit is configured to monitor information corresponding to ventricular depolarization (V-V) intervals using the sensed physiological signal; determine a V-V interval distribution; determine a heart rate density index (HRDI) as a portion of samples of the V-V interval distribution corresponding to a V-V interval occurring most often in the distribution; and generate an indication of atrial fibrillation (AF) using the HRDI.

Abstract: A system and method for cardiac activation imaging includes non-invasively or minimally invasively acquiring data about an electrical activation of a heart of a subject using at least one sensor. An activation image of the heart of the subject is reconstructed using a weighted sparse constrained reconstruction.

Abstract: Methods and an apparatus are provided, which may be used for determining the prognosis and/or diagnosis of a subject demonstrating burst suppression, whereby the subject has or is at risk of developing brain damage. In particular, the methods and apparatus determine the prognosis and/or diagnosis through the detection of bursts from a reading of electrical and/or electromagnetic activity of the subject's brain, such as an electroencephalogram (EEG), and subsequent analysis of one or more burst metrics derived therefrom.

Abstract: A method of identifying an epileptogenic zone of a brain includes receiving a plurality of electrical signals from a plurality of surgically implanted electrodes, calculating components of an adjacency matrix, calculating eigenvectors from the adjacency matrix, and selecting an eigenvector having a largest eigenvalue. The method includes assigning an integer rank to each component of the eigenvector, sliding the time window by a time increment and repeating the immediately preceding steps a plurality of times. The method includes normalizing each rank signal, extracting a multidimensional feature vector from each normalized signal, projecting each multidimensional feature vector onto a reduced dimensionality space, and receiving a plurality of training data points represented in the reduced dimensionality space.

Abstract: Methods of analysis to extract and assess brain data collected from subject animals, including humans, to detect intentional and unintentional brain activity and other unexpected signals are disclosed. These signals are correlated to higher cognitive brain functions or unintended, potentially adverse events, such as a stroke or seizure, and to translation of those signals into defined trigger events or tasks.

Abstract: An initial set of parameters for operating one or more detection tools is automatically derived and subsequently adjusted so that each detection tool is more or less sensitive to signal characteristics in a region of interest. Detection tool(s) may be applied to physiological signals sensed from a patient (such as EEG signals) and may be configured to run in an implanted medical device that is programmable with the parameters to look for rhythmic activity, spiking, and power changes in the sensed signals, etc. A detection tool may be selected and parameter values derived in a logical sequence and/or in pairs based on a graphical representation of an activity type which may be selected by a user, for example, by clicking and dragging on the graphic via a GUI. Displayed simulations allow a user to assess what will be detected with a derived parameter set and then to adjust the sensitivity of the set or start over as desired.

Abstract: Signal recording sensor systems in accordance with embodiments of the invention include sensors capable of sensing and capturing electrophysiological signals in the presence of interference signals, an analog front-end including circuitry configured to record electro-physiological input signals as a voltage, and an analog to digital converter including a voltage-controlled-oscillator configured to convert the recorded analog electrophysiological input signal to a phase output. While such signal recording sensor systems can be used in the recording of biosignals and/or electrophysiological signals generated from living organisms, signal recording sensor systems in accordance with embodiments of the invention are not limited to recording biosignals and/or electrophysiological signals.

Abstract: Methods and apparatus perform periodic breathing detection, such as Cheyne-Stokes respiration detection. The detection may be performed by one or more processors, such as by analysis of data from one or more sensors. In some cases, the detection may be based on an electrocardiogram (ECG) signal, such as from ECG electrodes and/or an accelerometer signal, such as from an accelerometer. An occurrence of periodic breathing may be detected based on features derived from the signal(s). For example, detection may be based on deriving a respiration signal from the sensed signal(s) and/or analysis of RR interval times or relative QRS amplitude values, which may be evaluated on a segment-by-segment basis. The detection may provide monitoring and reporting of the occurrence of periodic breathing by a monitoring device and/or provide a basis for controlling changes to a provided respiratory treatment or therapy, such as by a respiratory pressure therapy device.

Abstract: A method of determining the susceptibility to ventricular arrhythmias in a subject, the method including determining a reserve of refractoriness (RoR) and a reserve of memory (RoM) and combining the reserve of refractoriness (RoR) and the reserve of memory (RoM) to produce a metric of stability-of-propagation reserve (SoPR) in the subject, a higher value of SoPR indicating lower susceptibility to ventricular arrhythmias in the subject. Systems and apparatus for carrying out the method are also described.

Abstract: The present disclosure is related to an electroencephalography signal collecting apparatus, comprising an electrode module, a TGAM module, a data outputting module, a power source module and a frame. The modules are disposed on the frame. The electrode module and the power outputting module are electrically connected to the TGAM module respectively. The electrode module transmits the collected electroencephalography signal to the TGAM module and is attached on the head of a wearer. The TGAM module is coupled to a vehicle apparatus outside of the electroencephalography signal collecting apparatus through the data outputting module, transmits the electroencephalography signal to a digital signal and outputs the digital signal to the vehicle apparatus. The vehicle intelligent terminal controlled through the electroencephalography signal is achieved and the operation of the driver is reduced. The intelligence and the convenience of the vehicle controlling operation is improved.

Abstract: A user physiological condition sensing apparatus constituted of: a thermal sensor, the thermal sensor arranged to be positioned on the neck of the user and sense the skin temperature of the user; a core temperature functionality in communication with the thermal sensor, the core temperature functionality arranged to determine the core temperature of the user responsive to the sensed skin temperature; and an output module in communication with the core temperature functionality, the output module arranged to output the determined user core temperature, wherein the core temperature determination is further responsive to the weight and height of the user.

Abstract: Neural activity in the brain arising from a stimulus is monitored. A stimulus is applied to a target structure of the brain and a neural measurement is obtained from at least one electrode implanted in contact with the target structure. The neural measurement is configured to capture a measure of any late response arising in the target structure, typically being a neural response arising after conclusion of an ECAP, such as in the period 1.5-10 ms after stimulus onset. The late response(s) can be a useful biomarker such as of therapeutic ranges of deep brain stimulation, disease progression, medication efficacy, and intra-operative changes.

Abstract: A neurological condition detection unit can include a computer device that is connected to at least two leads that are connectable to a patient for evoking a response from that patient via an electrical current passed through the leads (e.g. a shock) and at plurality of sensors connected to the computer device to sense how the left side and right side of the patient's brain reacts to the evoked event (e.g. the shock). The stroke detection device and/or neurological condition detection unit can be configured to output a warning when one side of the patient's brain is determined to react differently than the opposite side of the patient's brain by at least a pre-selected threshold value. The warning can include an identification of a nearby care facility that may be best suited for providing care to a patient determined to have a neurological condition (e.g. a stroke).

Abstract: A system for providing a standard electrocardiogram (ECG) signal for a human body using contactless ECG sensors for outputting to exiting medical equipment or for storage or viewing on a remote device. The system comprises a digital processing module (DPM) adapted to connect to an array of contactless ECG sensors provided in a fabric or the like. A selection mechanism is embedded into the DPM which allows the DPM to identify body parts using the ECG signals of the different ECG sensors and select for each body part the best sensor lead. The DPM may then produce the standard ECG signal using the selected ECG signals for the different body parts detected. The system is adapted to continuously re-examine the selection to ensure that the best leads are selected for a given body part following a movement of the body part, thereby, allowing for continuous and un-interrupted ECG monitoring of the patient.

Abstract: Systems and methods for electrocardiography monitoring use multiple capacitive sensors in order to determine reliable measurements of electrophysiological information of a patient. Relative coupling strength and/or reliability is used to select dynamically which sensors to use in order to determine, in particular, an electrocardiogram of the patient.

Abstract: Disclosed are piston actuator devices and their uses for magnetic resonance elastography (MRE).

Abstract: A distributed imaging system uses non-ionizing radiation in the form of microwaves to image the body. This non-ionizing radiation is safer for a patient than traditional x-rays. The majority of image processing takes place in a centralized computing environment which receives microwave image data from many remote data acquisition sites (such as imaging centers, radiology groups, and/or doctor's offices). The centralized computing environment is specially configured to receive microwave image data from many sites and produce microwave images based on the received microwave image data. The microwave images may then be sent back to the acquisition site and/or to other sites for viewing and evaluation. This relieves the image data acquisition site of the burden and expense of having specialized high speed computer equipment that is necessary to produce microwave images.

Abstract: In various specific embodiments, a localizer can include a plurality of coil groups, where each coil group includes three coils that are formed around a single center. Each of the three coils can be formed around separate jigs and the jigs can be interconnected to form the coil group. The jigs need not be annular, but may be formed in any appropriate configuration of shape or geometry for forming the final coil group.

Abstract: A magnetic field generator assembly (44) is configured to be associated with a table (20) supporting a body. The magnetic field generator comprises magnetic field transmitters (57A) that are thin (of minimal height) and transparent, or substantially transparent, to x-ray radiation. The magnetic field transmitters (57A) are configured to minimally obstruct components of an imaging system and to minimally interfere with image quality. A plurality of transmitters is arranged in a first layer of the assembly. Each transmitter (57A) comprises an elongate conductive element, such as a wire, arranged in a spiral form, such as a coil.

Abstract: The present invention relates to an apparatus for tracking a device comprising a magnet as the device is inserted through a subject. The apparatus is wearable by the subject and comprises a unit configured to conform to the subject. The apparatus further comprises magnetic sensors arranged with the unit. In use, the magnetic sensors detect magnetic fields of the magnet and the detected magnetic fields are processed to determine a position of the magnet. This allows tracking of the device as the device is inserted through the subject.

Abstract: Provided is a biopsy needle with an electrode array which measures impedance for a plurality of biopsy points in real time, in which the needle includes electrode patterns configured by a plurality of electrode arrays on the surface, and the electrode patterns are spaced apart from each other along the top and bottom of the needle. According to the present invention, it is possible to selectively measure a predetermined tissue around the needle according to a direction of electrode formation and the number of electrodes while measuring impedance by using a plurality of electrodes by proposing a biopsy needle with a plurality of electrode arrays on a surface.

Abstract: A method and system for assessing electrode-tissue contact before the delivery of ablation energy. The system may include a control unit programmed to determine a difference between a maximum impedance magnitude at a low frequency for a given electrode and an absolute minimum impedance magnitude at the low frequency across all electrodes, determine a difference between a maximum impedance magnitude at a high frequency for a given electrode and an absolute minimum impedance magnitude at the high frequency across all electrodes, and determine a difference between a maximum impedance phase at the high frequency for a given electrode and an absolute minimum impedance phase at the high frequency across all electrodes. Differences may be correlated to one another using a linear model, the results determining electrode-tissue contact status. The results may be displayed in a graphical format for easy communication to the user.

Abstract: A method and system for assessing electrode-tissue contact before the delivery of ablation energy. The method may generally include determining a difference between a maximum impedance magnitude at a low frequency for a given electrode and an absolute minimum impedance magnitude at the low frequency across all electrodes, determining a difference between a maximum impedance magnitude at a high frequency for a given electrode and an absolute minimum impedance magnitude at the high frequency across all electrodes, and determining a difference between a maximum impedance phase at the high frequency for a given electrode and an absolute minimum impedance phase at the high frequency across all electrodes. These differences may be correlated to one another using a linear model, the results of which determining whether the given electrode is in contact or not in contact with tissue.

Abstract: During the transmission of sensor data of an implantable sensor with a measurement data recorder, an energy storage unit and a transmitter unit to an external data processing unit with a transmitter/receiver unit, a high-frequency energy carrier signal is firstly emitted from an energy supply unit. At least a part of the energy contained in the high-frequency energy carrier signal is stored in the energy storage unit of the implantable sensor. After the ending of the emission of the high-frequency energy carrier signal, a sensor measurement is carried out using the measurement data recorder of the implantable sensor. The measured sensor data are transmitted from the transmitter unit of the implantable sensor to the transmitter/receiver unit of the external data processing unit. The result is a transmission method, in which interference from the HF feed is avoided, with a compact design.

Abstract: A respiratory therapy instrument providing a telehealth platform for pulmonary care includes a housing with opposed extension arms, an airway tube removably clamped between the opposed extension arms, a pair of pressure sensors, and a circuit board retained within the housing. The pressure sensors are in communication with an interior of the airway tube and are configured to detect pulmonary flow data within the airway tube. The circuit board is configured to collect the pulmonary flow data detected by the pair of pressure sensors and includes a transmitter to send data, including the collected pulmonary flow data, wirelessly to a computing device. The collected pulmonary flow data is utilized in game play for an incentivization game operated on the computing device.

Abstract: There is provided a method, apparatus, computer program product and wearable device for monitoring volumetric change of a lung during a breathing cycle by using an electronic signal. The method comprises: receiving by a receiver an electronic signal transmitted from a transmitter, wherein at least part of a path of the signal contours at least part of a chest wall of the lung; determining by the receiver measurements of an attribute of the signal received at the beginning and the end of a time interval during the breathing cycle; calculating by a processor a change in length of the signal path during the time interval based on the measurements of the attribute of the signal received at the beginning and the end of the time interval; and calculating by the processor a volumetric change during the time interval based on the change in signal path length.

Abstract: The invention is a system and method for measuring 3D distances and dimensions of objects in endoscopic images by using a light plane to make Euclidean and geodesic measurements. The endoscopic measurement system of the invention comprises a flexible or rigid endoscopic device equipped with standard visualization means and a module containing components for generating a light plane. Based on triangulation, the intersection curve between the light lane and the object of interest is measureable in 3D in the coordinate system of the visualization means.

Abstract: A method and wearable device are provided.

Abstract: A system for detecting and recording head orientations of a person includes: a first sensor device capable of providing sensor data regarding a head orientation of a person in a three-dimensional space; a medical data acquisition system configured for storing and outputting the sensor data from the first sensor device; and a processor configured for processing the sensor data from the medical data acquisition system, outputting a first signal representing the head orientation, and generating an image for presentation by a graphical display; wherein the image comprises: a first reference indicator; an orientation indicator, wherein a position of the orientation indicator in the image is determined based on the first signal from the processor, and a feedback indicator when a first condition is met.

Abstract: In order to capture an image of a living body with reduced noise, an image capturing apparatus includes a main body that captures a living body image, and a support attachable to and detachable from the main body. The image capturing apparatus supports the living body with a finger guide and a wrist guide of the support, and guides light emitted from the main body through the support toward its top face side from its bottom face side where the main body contacts with the support, and radiates the guided light toward the living body from a light radiating section provided at a predetermined position of an inner wall and an end portion of the top face side of the support, so that the main body captures a living body image.

Abstract: A method for detecting characteristics of a Eustachian tube of a patient includes communicating pressurized air into an oro-nasal cavity of the patient. The method further includes directing an energy signal into the oro-nasal cavity. The method further includes detecting transmission of the energy signal from the oro-nasal cavity through the Eustachian tube with a sensor. The method further includes determining at least one characteristic of the Eustachian tube based on whether the energy signal is detected by the sensor.

Abstract: Various embodiments of optical computing devices utilized in healthcare-related applications.

Abstract: A metabolite concentration is measured in vivo using Raman spectroscopy in such a way as to receive at a detector light scattered from the metabolite in interstitial fluid in skin in a measurement location at a depth of from 200-300 ?m below the skin surface providing improved retention of correct calibration and transferability of calibration between individual subjects.

Abstract: A flexible, multi-layered device for automatically sensing sweat biomarkers, storing and transmitting sensed data via wireless network to a computing device having software applications operable thereon for receiving and analyzing the sensed data. The device is functional in extreme conditions, including extremely hot temperatures, extremely cold temperatures, high salinity, high altitude, extreme pHs, and/or extreme pressures.

Abstract: A continuous glucose monitoring system and a monitoring terminal are provided, wherein the monitoring system comprises a monitoring terminal and a mobile terminal; wherein the monitoring terminal includes a portable host and probe assembly which is assembled to the host; the mobile terminal includes a second data communication unit and a User interface; the probe assembly includes two glucolase micro electrode needles, a micro processor, and two electrode terminals; the host includes a signal sampling unit, a signal processing unit, a data storage unit, and a first data communication unit. By using the portable host equipped with the probe assembly to carry out the sampling of the blood glucose data, and sending the detection data continuously to the mobile terminal to continuously monitor the blood glucose, the collection and analysis of the blood glucose data is facilitated, thereby providing a reliable basis for the diabetes treatment.

Abstract: A dynamic blood glucose data acquiring device and a host are provided, wherein the collecting device comprises a portable host and a probe assembly; the probe assembly includes two glucolase micro electrode needles and a first circuit board; a first electrode terminal is provided on the first circuit board; the host includes an outer shell and a second circuit board which is located in the outer shell, and a second electrode terminal is provided on the second circuit board; the outer shell further includes a probe mounting position and a fixing structure; the probe assembly is mounted into the probe mounting position in such a way that the glucolase micro electrode needles are projected out of a lower surface of the outer shell; when the probe assembly is mounted into the probe mounting position, the first electrode terminal is electrically connected to the second electrode terminal.

Abstract: A system (2) for non-invasive measurement of the osmolality of biological tissue fluid in a living specimen (3) includes an RF generator for generating RF signals and transmitting these via an appropriate antenna towards tissue of a living specimen. An RF receiver (8) is coupled to another antenna, for receiving and measuring the intensity the RF signals reflected from aforementioned tissue, and for feeding said intensity to a processor (10) for comparison of relative reflection intensities of at least two RF frequencies impinging on the tissue with a reference reflection ratio signal.

Abstract: A nanoparticle conjugate includes a nanoparticle, first oligonucleotides of one or more types bound to the nanoparticle, each type of first oligonucleotide having a sequence, and targeting conjugates of one or more types, each type of targeting conjugate comprising a targeting entity and a second oligonucleotide bound to the targeting entity and having a sequence that is complementary to a sequence of a predetermined type of the first oligonucleotides, wherein the second oligonucleotide are covalently bound to a surface of the nanoparticle, a functional group on the surface of the nanoparticle, or one of the first oligonucleotide. Also provided are methods for making such nanoparticle conjugates and methods and devices for using such nanoparticle conjugates.

Abstract: One embodiment is directed to a system comprising a head-mounted member removably coupleable to the user's head; one or more electromagnetic radiation emitters coupled to the head-mounted member and configured to emit light with at least two different wavelengths toward at least one of the eyes of the user; one or more electromagnetic radiation detectors coupled to the head-mounted member and configured to receive light reflected after encountering at least one blood vessel of the eye; and a controller operatively coupled to the one or more electromagnetic radiation emitters and detectors and configured to cause the one or more electromagnetic radiation emitters to emit pulses of light while also causing the one or more electromagnetic radiation detectors to detect levels of light absorption related to the emitted pulses of light, and to produce an output that is proportional to an oxygen saturation level in the blood vessel.

Abstract: Methods and devices for accurate noninvasive measurement of blood analyte concentrations are disclosed. In an example process, optical properties of a blood vessel proximate to the surface of an exposed body part, for example, the sclera or the backside of the eyelid, is measured. Analyte concentrations are determined based on the measured optical properties.

Abstract: An integrated testing device is described, for example for testing bodily fluids. The device has a test component, a reservoir containing a test fluid, and a control vessel. The reservoir discharges test fluid into the control vessel, which discharges the test fluid in a controlled way to the test component.

Abstract: Methods, devices, systems and kits for obtaining blood samples are provided. Devices include a cuff, a pressure source, and a timing mechanism. Devices may further include one or more of a: warming mechanism, lancing mechanism; automated sample collection device, automated sample analysis device, and communication unit. Systems include such a device, and may include sample collection, sample analysis, or communication devices. Methods include placing a cuff on a digit of a subject, inflating the cuff, and obtaining a small volume blood sample. Methods may further include warming a digit; lancing a digit; pulsing the cuff; and providing a signal indicating the end of the sample collection time period. Kits may include a device, a sample collection vessel, and may include a disposable for use in sample collection. These methods, devices, systems and kits for obtaining blood samples may be used to easily, reliably, and consistently obtain blood samples from subjects.

Abstract: The present invention relates to a system and method for assessing and training the quality of attentional awareness and control of an individual. The individual's attention is monitored using a neurophysiological system such as EEG while using a computer system and display that provides signals that allow the correlation of behavioral measures of attention with neurophysiological measures. The combination of those signals is a novel, accurate and reliable system for assessing any individual's true attention capabilities.

Abstract: The present invention relates to a safety support system (10), comprising a data interface (20) for receiving sleep quality data carrying information on the sleep quality of a person (12), a sleep quality assessment unit (22) for determining a sleep quality indicator being indicative of the sleep quality of the person (12) based on the received sleep quality data and a safety unit (24) for determining machine operation settings for the person (12) based on the sleep quality indicator, said machine operation settings being indicative of an allowed operation of a machine (14) by the person (12). The present invention further relates to a corresponding method and to a machine (14) comprising a safety support system (10) as described above.

Abstract: A biological information generation method for generating graphic information for diagnosing a biological condition of a subject by using an olfactory stimulant includes: a step of classifying, according to a height of a polarity and a charged state, fragrant components capable of constituting olfactory stimulants into N classifications; a step of associating the fragrant components of each classification with an action thereof; a step of determining an unpleasure degree for olfactory stimulation given to the subject with respect to the N types of the olfactory stimulants; a step of assigning a correlation coefficient of the classification according to a main component in the N types of the olfactory stimulants and the actions associated with the corresponding classifications; and a step of generating graphic information for illustrating the biological condition of the subject with respect to each of the classifications.