Patents Issued in October 18, 2016
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Patent number: 9469806Abstract: Method of Making particles including a YAG core and a coating of sintering aid deposited thereon. The particles and agglomerates thereof maybe formed as a powder. The coated YAG-containing particles are well-suited to production of polycrystalline YAG-containing ceramics. The coated YAG-containing particles may be fabricated using a novel fabrication method which avoids the need for formation of a homogeneous powder mixture of YAG and sintering aid. The mixture may be sprayed into a drying column and dried to produce coated particles. Alternatively, the YAG particles and sintering aid or sintering aid precursor solution may be separately introduced to the drying column and dried to form coated YAG-containing particles.Type: GrantFiled: December 6, 2012Date of Patent: October 18, 2016Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Guillermo R. Villalobos, Jasbinder S. Sanghera, Woohong Kim, Shyam S. Bayya, Bryan Sadowski, Ishwar D. Aggarwal
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Patent number: 9469807Abstract: A chromic luminescent composition and method for fabricating the composition are disclosed. The chromic luminescent composition comprises at least one or more non-luminescent materials and one or more luminescent materials. The one or more non-luminescent materials having absorption spectra that at least partially overlap with the spectrum of incident electromagnetic radiation. The one or more luminescent materials convert at least a portion of energy of incident electromagnetic radiation to a lower energy wavelength. The one or more non-luminescent materials and the one or more luminescent materials are selected such that, when subsequently exposed to incident electromagnetic radiation, color and brightness are substantially modulated through absorption and emission as a function of incident electromagnetic radiation. Also disclosed are a chromic luminescent textile and a method for fabricating the textile.Type: GrantFiled: May 30, 2012Date of Patent: October 18, 2016Assignee: PERFORMANCE INDICATOR, LLCInventors: Satish Agrawal, Louis Cincotta, Edward D. Kingsley, Nancy Lane
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Patent number: 9469808Abstract: The present invention relates to fluorescent dye loaded particles and the method of preparing thereof. The method includes steps of preparing the nanoparticles with layered structure having at least one interlayer space, expanding the at least one interlayer space to form at least one expanded interlayer space, introducing the dye molecules to the at least one expanded interlayer space, and covalently bonding the dye molecules with the layered structure. The present invention also relates to a film comprising such nanoparticles.Type: GrantFiled: June 17, 2014Date of Patent: October 18, 2016Assignee: City University of Hong KongInventors: Yan Li, Xianfeng Chen
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Patent number: 9469809Abstract: To provide a liquid crystal composition satisfying at least one characteristic such as a high maximum temperature of a nematic phase, a low minimum temperature thereof, a small viscosity, a suitable optical anisotropy, a large negative dielectric anisotropy and specific resistance, a high stability to ultraviolet light and heat; a liquid crystal composition having a suitable balance regarding at least two of the characteristics; and an AM device having a short response time, a large voltage holding ratio and contrast ratio, a long service life; a solution is a liquid crystal composition that has a negative dielectric anisotropy, and contains a specific compound having a large negative dielectric anisotropy as a first component and a specific compound having a small viscosity as a second component, and may contain a specific compound having a large negative dielectric anisotropy as a third component, and a liquid crystal display device including the composition.Type: GrantFiled: January 25, 2013Date of Patent: October 18, 2016Assignees: JNC CORPORATION, JNC PETROCHEMICAL CORPORATIONInventors: Kazuhiko Saigusa, Yoshimasa Furusato
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Patent number: 9469810Abstract: The present invention relates to a polymerizable composition useful as a liquid crystal device, a display, an optical member, a coloring agent, a security marking, and a laser light emitting member and a thin film obtained from the polymerizable composition. The present invention provides a polymerizable liquid crystal composition having excellent solubility into a solvent, exhibiting good adhesion to a base material, and being capable of realizing a thin film having low haze and no variations and, in addition, provides a thin film having excellent appearance by using the polymerizable liquid crystal composition. The polymerizable liquid crystal composition according to the present invention is used and, thereby, a composition and a thin film having low haze and no variations and, at the same time, having excellent adhesion to a base material can be obtained at a low cost.Type: GrantFiled: November 21, 2012Date of Patent: October 18, 2016Assignee: DIC CORPORATIONInventors: Hidetoshi Nakata, Yasuhiro Kuwana, Hiroshi Hasebe, Kunihiko Kotani, Isa Nishiyama
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Patent number: 9469811Abstract: The invention relates to a tool for crushing coke, and includes a housing 2 that, in an operating state, is fastened to a drill rod, and in which is arranged at least one cutting nozzle 10 for cutting and a drilling nozzle 9 for drilling coke by means of a water jet, and a control for supplying water flowing through the housing 2 under pressure for drilling or cutting, wherein the control for switching the tool 1 from a drilling mode to a cutting mode and vice versa includes a control device 7 that is rotatable about a longitudinal axis of the housing 2 to switch the tool 1, wherein the drilling or cutting mode is set depending on the angular position of the control device 7. To obtain a clear understanding of whether the tool 1 is in drilling or cutting mode, at least one position element 38, 39 is arranged on the control device 7 that displays the angular position of the control device 7 in the drilling and/or cutting mode of the tool 1 through a window 18 in the housing 2.Type: GrantFiled: June 2, 2014Date of Patent: October 18, 2016Assignee: Ruhrpumpen GmbHInventors: Thomas Hoppe, Wolfgang Paul, Kay Simon, Andreas Wupper
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Patent number: 9469812Abstract: A process and system for the controlled thermal conversion of a carbonaceous feedstock, including: exposing the feedstock to one or more predetermined temperatures and one or more predetermined pressures for one or more predetermined amounts of time in one or more chambers to produce a gas product and a solid product, wherein the gas product includes one or more of methane, carbon monoxide, hydrogen, and one or more noxious chemicals and the solid product includes Carbon; sequestration enabling at least a portion of the Carbon by creating associated Lewis Acid Sites; sequestering at least one of the one or more noxious chemicals in the one or more chambers using the sequestration enabled Carbon; and controlling the constituents of the gas product using feedback, thereby providing a predictable and stable gas product from an unknown and/or variable feedstock.Type: GrantFiled: September 10, 2012Date of Patent: October 18, 2016Assignee: Tucker Engineering Associates, Inc.Inventor: Richard D. Tucker
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Patent number: 9469813Abstract: Method for recovering bitumen from tar sands, according to which sands are brought into contact with at least one partially hydrolyzed poly(vinyl acetate) (co)polymer A.Type: GrantFiled: March 28, 2014Date of Patent: October 18, 2016Assignee: S.P.C.M. SAInventors: Cedrick Favero, Morgan Tizzotti, Nicolas Gaillard
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Patent number: 9469814Abstract: A process for extracting bitumen from an oil sand ore having a fines content up to about 60% and a bitumen content higher than about 6% is provided, comprising mixing the oil sand ore with heated water to form an oil sand slurry; conditioning the oil sand slurry to form a conditioned oil sand slurry; introducing a dosage of sodium citrate to the process either prior to or during the mixing step, or prior to or during the conditioning step, or both; and introducing the conditioned oil sand slurry into a separation zone to form a bitumen froth and tailings.Type: GrantFiled: January 28, 2015Date of Patent: October 18, 2016Assignee: SYNCRUDE CANADA LTD. in trust for the owners of the Syncrude Project as such owners exist now and in the futureInventors: Jun Long, Yong Joe Gu
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Patent number: 9469815Abstract: A process for catalytic cracking of a pyrolysis oil derived from material comprising biomass. In one embodiment, the process comprises subjecting a feed comprising the pyrolysis oil to a hydrodeoxygenation step to prepare an at least partially deoxygenated pyrolysis oil; heating a hydrocarbon feed to a temperature in the range from equal to or more than 50° C. to equal to or less than 200° C. to prepare a preheated hydrocarbon feed; mixing the at least partially deoxygenated pyrolysis oil and the preheated hydrocarbon feed to prepare a feed mixture; and contacting the feed mixture with a catalytic cracking catalyst in a catalytic cracking reactor at a temperature of at least 400° C. to prepare a product stream containing one or more cracked products.Type: GrantFiled: October 22, 2013Date of Patent: October 18, 2016Assignee: Shell Oil CompanyInventors: Gang Wang, Jinsen Gao, Yantao Bi
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Patent number: 9469816Abstract: Disclosed is a process for the upgrading and demetallizing of heavy oils and bitumens. A crude heavy oil and/or bitumen feed is supplied to a solvent extraction process 104 wherein DAO and asphaltenes are separated. The DAO is supplied to an FCC unit 106 having a low conversion activity catalyst for the removal of metals contained therein. The demetallized distillate fraction is supplied to a hydrotreater 110 for upgrading and collected as a synthetic crude product stream. The asphaltene fraction can be supplied to a gasifier 108 for the recovery of power, steam and hydrogen, which can be supplied to the hydrotreater 110 or otherwise within the process or exported. An optional coker unit 234 can be used to convert excess asphaltenes and/or decant oil to naphtha, distillate and gas oil, which can be supplied to the hydrotreater 220.Type: GrantFiled: May 12, 2008Date of Patent: October 18, 2016Assignee: Kellogg Brown & Root LLCInventors: Rashid Iqbal, Anshumali, Odette Eng, Phillip Niccum
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Patent number: 9469817Abstract: A hydrocracking catalyst comprises a support, at least one of VIII Group metal components, and at least one of VIB Group metal components. The support comprises an acidic silica-alumina component and alumina derived from a pseudo-boehmite component, wherein the content of the acidic silica-alumina component is 3-80 wt %, the content of alumina derived from the pseudo-boehmite component is 20-95 wt %, based on the support. The support is obtained by mixing, molding, drying and calcining the acidic silica-alumina component with the pseudo-boehmite component, wherein said pseudo-boehmite component comprises pseudo-boehmite PB1 and pseudo-boehmite PB2, wherein the content of PB1 is 10-90 wt % and the content of PB2 is 0-60 wt % on a dry basis and based on the support.Type: GrantFiled: February 19, 2015Date of Patent: October 18, 2016Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, RESEARCH INSTITUTE OF PETROLEUM PROCESSING, SINOPECInventors: Yichao Mao, Hong Nie, Mingfeng Li, Qinghe Yang, Zhihai Hu, Runqiang Zhang, Guangle Zhao
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Patent number: 9469818Abstract: The invention relates to a hydrocarbon composition, which can be used as a fuel and/or fuel oil, containing a petroleum component (A) and a component of a biological origin (B), wherein the component of a biological origin is present in a quantity of up to 75% by volume with respect to the total composition.Type: GrantFiled: November 10, 2014Date of Patent: October 18, 2016Assignees: ENI S.p.A., UOP LLCInventors: Franco Baldiraghi, Silvia Guanziroli, Giovanni Faraci, Luigina Maria Flora Sabatino, Terry Louise Marker, John Anthony Petri
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Patent number: 9469819Abstract: Embodiments are directed to a gasifier that electrodynamically agitates charged chemical species in a reaction region of a reaction vessel of a gasifier and related methods. In an embodiment, a gasifier includes a reaction vessel configured to gasify at least one hydrocarbon-containing feed material to synthesis gas. The reaction vessel includes an inlet(s) for receiving a gasification medium that reacts with the at least one hydrocarbon-containing feed material and an outlet for allowing the synthesis gas to exit from the reaction vessel, and a reaction region. The gasifier includes at least one electrode positioned to be in electrical communication with the reaction region, and a voltage source operatively coupled to the at least one electrode. The voltage source and the at least one electrode are cooperatively configured to generate a time varying electric field in the reaction region to effect electrodynamic mixing of charged chemical species therein during gasification.Type: GrantFiled: January 13, 2014Date of Patent: October 18, 2016Assignee: CLEARSIGN COMBUSTION CORPORATIONInventor: Christopher A. Wiklof
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Patent number: 9469820Abstract: A method for recycling carbon dioxide from biomass gasification. The method includes: 1) employing carbon dioxide as a gasifying agent, allowing the carbon dioxide to gasify biomass to yield syngas; 2) cooling the syngas; 3) introduced cooled syngas to a cyclone separator and a gas scrubber for dust removal and purification; 4) allowing purified syngas in 3) to react with the vapor to modify a ratio of hydrogen to carbon monoxide of the syngas; 5) desulfurizing modified syngas to remove H2S and COS therein; 6) decarburizing desulfurized syngas to separate carbon dioxide therein; 7) introducing desulfurized and decarburized syngas to a synthesizing tower to yield oil products and exhaust gas including carbon dioxide; 8) decarburizing the exhaust gas including carbon dioxide and separating the carbon dioxide; and 9) introducing the carbon dioxide separated in 6) and 8) to 1) as the gasifying agent for gasification.Type: GrantFiled: January 27, 2015Date of Patent: October 18, 2016Assignee: WUHAN KAIDI ENGINEERING TECHNOLOGY RESEARCH INSTITUTE CO., LTD.Inventors: Yanfeng Zhang, Liang Zhang, Minggui Xia, Wenyan Liu
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Patent number: 9469821Abstract: A collection of gasifier fueled engine systems is networked through a system of connecting pipes and valves in order to provide fast response to output power demands and to extend the range of power levels at which the system exhibits high conversion efficiency.Type: GrantFiled: July 31, 2014Date of Patent: October 18, 2016Assignee: V-GRID ENERGY SYSTEMSInventor: Michael Cheiky
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Patent number: 9469822Abstract: A method of hydrothermal hydrocatalytic treating biomass is provided. Lignocellulosic biomass solids is provided to a hydrothermal digestion unit in the presence of a digestive solvent, and a supported hydrogenolysis catalyst containing (a) sulfur, (b) Mo or W, and (c) Co, Ni or mixture thereof, incorporated into an alumina support, which support is predominantly alpha alumina; (ii) heating the lignocellulosic biomass solids and digestive solvent in the presence of hydrogen, and supported hydrogenolysis catalyst thereby forming a product solution containing plurality of oxygenated hydrocarbons, said alumina support having a specific surface area of up to about 30 m2/g and said catalyst retaining a crush strength of at least 50% after being subjected to an aqueous phase stability test compared with before the aqueous phase stability test or a crush strength of at least 0.25 kg after being subjected to an aqueous phase stability test.Type: GrantFiled: December 19, 2013Date of Patent: October 18, 2016Assignee: Shell Oil CompanyInventors: Joseph Broun Powell, Glenn Charles Komplin, John Anthony Smegal, Kimberly Ann Johnson
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Patent number: 9469823Abstract: The invention provides a lubricating composition containing a ?-amino compound. The invention further relates to a method of lubricating an internal combustion engine by lubricating the engine with the lubricating composition. The invention further relates to the use of the ?-amino carbonyl compound as copper corrosion inhibitors, friction control agents, antiwear and/or extreme pressure agents.Type: GrantFiled: November 10, 2014Date of Patent: October 18, 2016Assignee: The Lubrizol CorporationInventors: Matthew D. Gieselman, Jody A. Kocsis
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Patent number: 9469824Abstract: A composition of an oil-soluble ionic detergent that does not contribute metal ions to the composition, and which comprises a quaternary non-metallic pnictogen cation and an organic anion having at least one hydrocarbyl group of sufficient length to impart oil solubility to the detergent, the detergent having a total base number (TBN) to total acid number (TAN) ratio of at least 2:1 imparts ash-free basicity to a lubricant composition.Type: GrantFiled: May 14, 2014Date of Patent: October 18, 2016Assignee: The Lubrizol CorporationInventors: Ewan E. Delbridge, Virginia A. Carrick, John K. Pudelski, Matthew D. Giesleman, Christopher L. Friend, Patrick E. Mosier, Michele M. Rogers, Mark T. Tierney
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Patent number: 9469825Abstract: A transmission lubricant composition, a method of lubricating a machine part, and a transmission are provided that utilize select boronated and phosphorylated N-substituted polyisobutylene succinimide dispersants combined with metal containing detergents to achieve high friction durability and low wear rates for automatic transmissions.Type: GrantFiled: March 12, 2015Date of Patent: October 18, 2016Assignee: Afton Chemical CorporationInventor: Tom Hong-Zhi Tang
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Patent number: 9469827Abstract: Methods are provided for refining natural oil feedstocks. The methods comprise reacting the feedstock in the presence of a metathesis catalyst under conditions sufficient to form a metathesized product comprising olefins and esters. In certain embodiments, the methods further comprise separating the olefins from the esters in the metathesized product. In certain embodiments, the methods further comprise hydrogenating the olefins under conditions sufficient to form a fuel composition. In certain embodiments, the methods further comprise transesterifying the esters in the presence of an alcohol to form a transesterified product.Type: GrantFiled: January 6, 2015Date of Patent: October 18, 2016Assignee: Elevance Renewable Sciences, Inc.Inventors: Steven A. Cohen, Melvin L. Luetkens, Jr., Chander Balakrishnan, Robert Snyder
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Patent number: 9469828Abstract: Provided are tablet binding compositions for binding cleaning and/or disinfecting formulation components into tablets. The tablet binding compositions are suitable replacements for traditional tablet binder compounds, such as boric acid or zeolites. The tablet binding compositions provided herein can produce tablets of increased hardness at lower compression forces and, when dissolved, yield solutions of increased clarity compared to some traditional binder compounds. Also provided are processes for preparing the tablet binding compositions and methods for formation of tablets containing the tablet binding compositions.Type: GrantFiled: October 10, 2014Date of Patent: October 18, 2016Assignee: ChemLink Laboratories, LLCInventor: Ryan Giffin Moore
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Patent number: 9469829Abstract: The present composition relates to fabric care compositions comprising an organosiloxane polymer. Methods of using such compositions including contacting a fabric with the composition and rinsing the fabric are also disclosed.Type: GrantFiled: June 24, 2015Date of Patent: October 18, 2016Assignee: The Procter & Gamble CompanyInventors: Rajan Keshav Panandiker, Kerry Andrew Vetter, Bernard William Kluesener, Iskender Yilgor, Christian Herzig, Richard Becker, Rafael Trujillo Rosaldo, Leslie Dawn Waits, Janine A. Flood, Keith Homer Baker, Jennifer Beth Ponder, Mark Gregory Solinsky, Matthew Scott Wagner, Pradipta Sarkar, Emily Suzanne Klinker, Julie Ann O'Neil
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Patent number: 9469830Abstract: A process of mashing grain into fermentable sugar wherein two pots are used in the process. A first pot and a second pot is partially filled with water. Heat is added to the first pot. Heat is transferred to the second pot by transferring the water from the first pot to the second pot at a preestablished rate. Grain is added to the second pot which in conjunction with the water forms a wort. The wort is drained from the second pot to the first pot.Type: GrantFiled: February 18, 2015Date of Patent: October 18, 2016Inventor: John Richard Blichmann
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Patent number: 9469831Abstract: Cycloserine resistant mutants of lactic acid bacteria characterized by having improved resistance towards ethanol. The cycloserine resistant mutants of lactic acid bacteria can e.g. be used for malolactic fermentations of wine (i.e. including sparkling wine such as Cava/champagne) having high alcohol levels.Type: GrantFiled: June 14, 2012Date of Patent: October 18, 2016Assignee: Chr. Hansen A/SInventors: Kim Ib Soerensen, Annette Kibenich, Eric Johansen
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Patent number: 9469832Abstract: The present invention provides for a photobioreactor for the cultivation of photosynthetic microorganisms and comprises a hydraulic circuit through which an aqueous solution containing culture of at least one type of photosynthetic organism circulates and gets exposed to a light source. The photobioreactor also comprises a means for feeding carbon dioxide into the system, a means for oxygen degasification, and a means for injecting nutrients into the system. The hydraulic circuit is comprised of two open receiving channels at the same relative elevation, a set of transparent or translucent tubes which connect receiving channels to each other, and at least one fluid moving device to move the fluid from the first to the second receiving channels through the tubes. Each receiving channel also comprises a dam which assists in maintaining two different surface levels of the aqueous solution within the upstream and downstream portions of each receiving channel.Type: GrantFiled: February 23, 2010Date of Patent: October 18, 2016Inventor: Jacinto Fernando Mena Mas
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Patent number: 9469833Abstract: The present invention provides a transplantation guide which is formed into a bottomed cylinder having a base material that allows communication of a culture fluid, wherein: a cell mass supplied from the open end side is placed on the base material, and the guide is used as a mold for forming a three-dimensional cell construct by culturing the cell mass placed on the base material by immersing the base material side in an excessive amount of a culture fluid.Type: GrantFiled: February 3, 2012Date of Patent: October 18, 2016Assignee: CYFUSE BIOMEDICAL K. K.Inventor: Koichi Nakayama
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Patent number: 9469834Abstract: A pair or receptacles capable of housing an emitter probe and a detector probe installed inside a bioreactor to monitor the properties of the nutrient media without contacting the nutrient media.Type: GrantFiled: August 28, 2013Date of Patent: October 18, 2016Assignee: Therapeutic Proteins International, LLCInventor: Sarfaraz K. Niazi
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Patent number: 9469835Abstract: Significant research is being done to develop and improve delivery mechanisms for biopharmaceuticals and vaccines, including pulmonary (inhalation), nasal, transdermal, and oral alternatives. Market projections indicate that the delivery of proteins and vaccines by inhalation and oral formulation has become and will continue to be increasingly important. These delivery mechanisms, to be effective, will require better stabilization of the biologicals so that they can maintain potency and effectiveness at ambient temperatures for extended periods of time. The novel Preservation by Vaporization (PBV) Technology described herein provides cost-effective and efficient industrial scale stabilization of proteins, viruses, bacteria, and other sensitive biologicals, thereby allowing a production of products that are not possible to be produced by existing methods. The suggested new PBV process comprises primary drying under vacuum from a partially frozen state (i.e.Type: GrantFiled: June 1, 2005Date of Patent: October 18, 2016Inventor: Victor Bronshtein
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Patent number: 9469836Abstract: The disclosure pertains to isolated white pine toxigenic endophytes and the compounds produced by the fungal endophytes as well as methods and uses of the white pine endophytes. The isolated white pine toxigenic endophytes are useful for preparing white pine seedlings and plants that have increased tolerance to a pest and are prepared by inoculating a white pine seedling during the susceptible time window.Type: GrantFiled: January 27, 2012Date of Patent: October 18, 2016Assignee: J.D. IRVING, LIMITEDInventors: John David Miller, Greg William Adams, Mark Sumarah
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Patent number: 9469837Abstract: Disclosed herein are materials and methods for creating and/or isolating variants of yeasts especially variants of Saccharomyces cerevisiae that can grow on sugars other than D-glucose in the presence of amounts of 2-deoxy-glucose and or D-glucose that inhibit most strains of yeast from growing on sugars other than D-glucose. Selection media that can be used to isolate such variants include pentose sugars such as D-xylose, L-glutamine and 2-deoxy-glucose. Mutations in the Grr1 and Red genes in some strains also produce variants that can grow on sugars including the pentose D-xylose in the presence of 2-deoxy-glucose.Type: GrantFiled: February 25, 2010Date of Patent: October 18, 2016Assignee: Indiana University Research and Technology CorporationInventors: Mark Goebl, Cary Woods, Ross Cocklin, Josh Heyen
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Patent number: 9469838Abstract: The process provides a biofilm including and not limited to cellulose produced by bacteria that can be used as a bio-resin and as a surface application for myceliated and non-myceliated biomaterials. In one embodiment, the process comprises the steps of obtaining an agricultural substrate; and cohabitating a selected bacteria with a selected fungus in the agricultural substrate for a period of time to allow the bacteria to grow alongside the fungus and to excrete a biofilm from the bacteria into the substrate to provide bio-resin like strengthening compounds to the agricultural substrate.Type: GrantFiled: June 19, 2015Date of Patent: October 18, 2016Assignee: Ecovative Design, LLCInventors: Damen Donald Schaak, Matthew James Lucht
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Patent number: 9469839Abstract: A cell culture support comprising a substrate, and a dual stimuli responsive block copolymer immobilized on the substrate, wherein the dual stimuli responsive block copolymer is both thermoresponsive and pH responsive. A method of culturing cells comprising the cell culture support having a dual stimuli responsive copolymer immobilized on a substrate, wherein the dual stimuli responsive copolymer is thermoresponsive and pH responsive; and growing the cells on the cell culture support. By lowering the temperature, cells are released from the cell culture support.Type: GrantFiled: June 29, 2009Date of Patent: October 18, 2016Assignee: General Electric CompanyInventors: Slawomir Rubinsztajn, Prameela Susarla, Anton Beletskii, Reginald Donovan Smith, Brian Polizzotti
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Patent number: 9469840Abstract: A guiding device in which cells are confined between a support surface and a textured surface of a substrate, said textured surface having an anisotropic three-dimensional structure having a repeating pattern that repeats according to a repeat axis, said repeating pattern having a succession of guide spaces adjacent to one another according to the repeat axis, each of said guide spaces being capable of receiving at least one portion of one of the cells and being oriented according to a direction of anisotropy to guide a movement of the cells in the direction of anisotropy.Type: GrantFiled: September 17, 2012Date of Patent: October 18, 2016Assignees: INSTITUT CURIE, SOCIETE DE DEVELOPPEMENT ET DE RECHERCHE INDUSTRIELLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRSInventors: Maël Le Berre, Matthieu Piel, Yanjun Liu
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Patent number: 9469841Abstract: The present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a prodrug activating enzyme and a protein that binds a cancer specific marker, polynucleotides encoding the polypeptides, and molecular switches for converting a prodrug into a toxin, comprising the polypeptides. The invention also features methods for converting a prodrug into a toxin, methods for treating cancer, and methods for making the molecular switches, as well as kits.Type: GrantFiled: May 30, 2014Date of Patent: October 18, 2016Assignee: The Johns Hopkins UniversityInventors: Marc A. Ostermeier, Chapman M. Wright
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Patent number: 9469842Abstract: The present invention relates to a Korean-type porcine reproductive and respiratory syndrome virus (PRRSV) and a vaccine composition using the same, and a method for preventing porcine reproductive and respiratory syndrome. Korean-type porcine reproductive and respiratory syndrome virus with accession number KCTC 12096BP according to the present invention is Korean-type porcine reproductive and respiratory syndrome virus distinguished from European strains and North American strains, and a vaccine composition specific to Korean-type porcine reproductive and respiratory syndrome virus is produced, thereby preventing a Korean-type porcine reproductive and respiratory syndrome virus or specifically diagnosing the infection with Korean-type porcine reproductive and respiratory syndrome virus.Type: GrantFiled: February 3, 2014Date of Patent: October 18, 2016Assignee: OPTIPHARM CO., LTD.Inventors: Hyun Il Kim, Seong Ho Shin, Beom Ku Han
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Patent number: 9469843Abstract: A method of extracting carotenoids from plant material generally includes acquiring plant material including carotenoids, treating the carotenoids with a first enzyme to create a first enzyme treated mixture, wherein the first enzyme includes cellulase, and separating the first enzyme extracted carotenoids from the first enzyme treated mixture. Natural carotenoid concentrate obtained from plant material are also provided.Type: GrantFiled: September 30, 2011Date of Patent: October 18, 2016Assignee: John Bean Technologies S.p.A.Inventors: Davide Ferrari, Antonio Aldini, Stefano Cuccolini
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Patent number: 9469844Abstract: A heat-resistant flavin-bound glucose dehydrogenase having a high substrate specificity for D-glucose, an method for producing the same, and a transformant used for the same. A flavin-bound glucose dehydrogenase gene encoding a flavin-bound glucose dehydrogenase derived from Mucor is introduced into yeast, Zygosaccharomyces, to obtain a transformant. Subsequently, the yeast transformant is cultured to obtain a flavin-bound glucose dehydrogenase from the culture. The heat-resistant flavin-bound glucose dehydrogenase is less susceptible to the effects of dissolved oxygen and allows accurate measurement of glucose even in the presence of sugar compounds other than glucose in a sample.Type: GrantFiled: November 30, 2011Date of Patent: October 18, 2016Assignee: KIKKOMAN CORPORATIONInventors: Ryoko Tajima, Atsushi Ichiyanagi, Kozo Hirokawa, Masanobu Yuzuki
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Patent number: 9469845Abstract: Secreted luciferases which are different from those known heretofore have been desired. The present invention provides a luciferase mutant comprising an amino acid sequence in which at least one amino acid selected from amino acids at the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2.Type: GrantFiled: May 18, 2016Date of Patent: October 18, 2016Assignee: JNC CORPORATIONInventors: Satoshi Inouye, Junichi Sato
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Patent number: 9469846Abstract: A composition for inhibiting cancer cell proliferation includes exogenous constitutively active Chk1 or an agent that promotes phosphorylation of endogenous Chk1 of the cancer cell.Type: GrantFiled: July 29, 2013Date of Patent: October 18, 2016Assignee: Case Western Reserve UniversityInventor: Youwei Zhang
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Patent number: 9469847Abstract: One aspect provides an ultrapure, hypoallergenic sacrosidase. Another aspect provides a solution of sacrosidase in about 1:1 glycerol/water having an enzymatic activity of at least about 7500 IU/mL and a residual papain concentration that does not include an allergic reaction in a human patient when given a dose of about 2.0 mL/day.Type: GrantFiled: August 17, 2015Date of Patent: October 18, 2016Assignee: QOL Medical LLCInventors: Dayton T. Reardan, Christopher Seekamp
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Patent number: 9469848Abstract: The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly, the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.Type: GrantFiled: June 30, 2011Date of Patent: October 18, 2016Assignee: DUPONT NUTRITION BIOSCIENCES APSInventors: Peter Edvard Degn, Richard R. Bott, Casper Willem Vroemen, Martijn Silvan Scheffers, Wolfgang Aehle, Elin Petersen
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Patent number: 9469849Abstract: Methods and systems for chromatographically purifying a botulinum neurotoxin are provided. These methods and systems allow for efficient purification of a non-complexed form of the botulinum neurotoxin in high purity and yield that can be used as an active ingredient in pharmaceutical preparations.Type: GrantFiled: July 10, 2015Date of Patent: October 18, 2016Assignee: Revance Therapeutics, Inc.Inventor: Curtis L. Ruegg
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Patent number: 9469850Abstract: The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates. Also provided are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-protein conjugate.Type: GrantFiled: May 8, 2014Date of Patent: October 18, 2016Assignee: Genzyme CorporationInventors: Yunxiang Zhu, Seng H. Cheng, Canwen Jiang, Luis Z. Avila
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Patent number: 9469851Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.Type: GrantFiled: July 24, 2012Date of Patent: October 18, 2016Assignee: NATIONWIDE CHILDREN'S HOSPITAL, INC.Inventors: Scott Quenton Harper, Jian Liu, Sara Garwick Coppens, Lindsay Wallace
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Patent number: 9469852Abstract: Compositions comprising therapeutic oligonucleotide miR-3151 compounds that target the expression of genes associated with tumorigenesis or cell transformation are provided.Type: GrantFiled: April 24, 2015Date of Patent: October 18, 2016Assignee: The Ohio State UniversityInventors: Albert de la Chapelle, Ann-Kathrin Eisfeld
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Patent number: 9469853Abstract: Disclosed herein are methods of treating a patient at risk of developing an inflammatory joint disease. In exemplary embodiments, the method involves inhibiting MCPIP levels in a patient in need, wherein said patient in need is exhibiting pre-arthritic or pre-osteoporotic symptoms.Type: GrantFiled: February 28, 2014Date of Patent: October 18, 2016Assignee: University of Central Florida Research Foundation, Inc.Inventor: Pappachan Kolattukudy
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Patent number: 9469854Abstract: The present invention relates to a pharmaceutical composition for treating liver diseases, comprising a miRNA mimic containing a single strand RNA molecule of hsa-miR-21-3p (SEQ ID No: 35). The miRNA mimic of the present invention can be used to treat liver diseases through regulating the expression of methionine adenosyltransferase 2A and 2B (MAT2A and MAT2B), acetyl-CoA carboxylase 1 and 2 (ACACA and ACACB), diglyceride acyltransferase 2 (DGAT2), and so on. In addition, the present invention also relates to a method for reducing the expression of the above-mentioned enzymes.Type: GrantFiled: October 2, 2015Date of Patent: October 18, 2016Assignee: ACADEMIA SINICAInventors: Shui-Tein Chen, Ting-Fang Lo, Wei-Chung Tsai
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Patent number: 9469855Abstract: The present invention provides a method of treating, attenuating or preventing a liver disorder by inhibiting NGn4 expression and thereby modulating the activity of NK cells. The present invention further relates to diagnosing a liver disorder by evaluating NLGn4 expression in NK cells.Type: GrantFiled: December 9, 2015Date of Patent: October 18, 2016Assignee: Hadasit Medical Research Services and Development Ltd.Inventor: Rifaat Safadi
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Patent number: 9469856Abstract: Compositions and methods for the inducible expression of genes in eukaryotic cells are provided. Expression of a nucleotide sequence of interest encoding a protein of interest is controlled by a regulatory fusion protein that consists of a transcription blocking domain and a ligand-binding domain. When a cognate ligand for the ligand-binding domain is present, transcription of the nucleotide sequence of interest is blocked. Upon removal of the cognate ligand, the nucleotide sequence of interest is transcribed. The method is useful for large scale bioreactor production of a desired protein of interest in eukaryotic cells.Type: GrantFiled: February 18, 2014Date of Patent: October 18, 2016Assignee: REGENERON PHARMACEUTICALS, INC.Inventors: Changlin Dou, Gang Chen, James P. Fandl