Abstract: A method of selecting a group from a plurality of multi objective designs which comply with a plurality of objectives. The method comprises providing a plurality of multi objective designs, each the multi objective design having a plurality of multi objective design objective values which comply with at least one constraint of a Pareto Frontier of an objective space of a plurality of objectives, selecting a group from the plurality of multi objective designs, each member of the group is selected according to a match between at least one objective of respective the plurality of objectives and at least one of a respective gain threshold and a respective loss threshold, and outputting the group.

Abstract: A system for testing at least a first automatic control device via a plant model includes: a first subsystem; and a second subsystem which is spatially separated from the first subsystem. The plant model comprises an executable first model code and an executable second model code. The first subsystem comprises a first time-signal processing component configured to electronically assign a first time signal (Ts1) from a global time source to a first event. The first model code is configured to provide a first calculation result based on the first event. The second subsystem comprises a second time-signal processing component configured to electronically assign a second time signal (Ts2) from the global time source to a second event. The second model code is configured to provide a second calculation result based on the second event.

Abstract: A method and apparatus for generating geometric data are to be used in the building of an object using a layer-by-layer additive manufacturing process. The method includes providing object data defining the object, identifying from the object data one or more regions of a surface of the object to be supported during the additive manufacturing process and, for the or each region, identifying one or more supporting structures that will provide support for the region and generating an arrangement of supports within the region. A support location of each support of the arrangement relative to the other supports of the arrangement is derived from a location of the supporting structures.

Abstract: An exemplary system, method and computer-accessible medium can be provided which can include, for example, generating a super control dataflow graph(s) (CDFG) by applying a plurality of electronic system level ESL design constraints associated with an integrated circuit, determining an upper bound(s) number and a lower bound(s) number based on a number of CDFGs in the super CDFG(s)—with each number being one metric of a capability of the integrated circuit to resist reverse engineering attack—, and inserting a component(s) into a register transfer level netlist to effectuate a modification of the upper bound(s) and the lower bound(s).

Abstract: Techniques for predicting a failure metric of a physical system using a semiparametric model, including providing raw data representative of the physical system, to identify a set of units at risk in the physical system, a set of times of treatment corresponding to a event of at least one unit in the set of units, and an index-set of the at least one unit for which a event has occurred. A parametric and a nonparametric component of the semiparametric model are estimated and a hazard rate is predicted at a given time with the semiparametric model.

Abstract: A method for obtaining a relation between a winding state and a leakage reactance parameter of a transformer by using simulation software is provided. The method includes: establishing a simulation transformer based on a size of a physical transformer; setting parameters of the simulation transformer, setting a winding of the simulation transformer in a predetermined winding state; obtaining a predetermined number of values of a leakage reactance parameter of the simulation transformer in the winding state; and performing statistics on all the values to obtain a value range of the leakage reactance parameter in a case that the winding is in the winding state. The value range is used as a value range of a leakage reactance parameter of the physical transformer in a case that a winding of the physical transformer is in the winding state.

Abstract: Aspects of the present invention provide a solution for calibrating a model of a complex flow system. In an embodiment, a comparison is made between the output from the model and a set of observed values for each of a plurality of nodes in the complex flow system. An adjoint sensitivity is computed for each of the nodes based on the comparison. These computed adjoint sensitivities are used to adjust a set of coefficients of the models. This calibration process can be performed multiple times, periodically and/or continuously to maximize the accuracy of the model.

Abstract: A computer implemented method of estimating solar irradiance, the method comprising: constructing a reference irradiance set of tuples; constructing a reference predictor set of tuples, merging the reference irradiance set of tuples and the reference predictor set of tuples by matching numerical identifiers for a location for which a global horizontal irradiance exists in the reference irradiance set of tuples and the timestamp with the numerical identifier for a particular location in the reference predictor set of tuples and the timestamp to provide a reference data set of tuples; and estimating the global horizontal irradiance for a specific location and a timestamp by minimizing the least squares error between the reference predictor set of tuples and the reference irradiance set of tuples to provide a set of estimated global horizontal irradiance values for a specific location and timestamp.

Abstract: This invention relates to the numerical method for simulating inviscid subsonic flows by solving two-dimensional Riemann problem. this invention transforms the Euler equations into a stream-function plane and solve the equations under an uniform computing grid by solving the two-dimensional Riemann problem across streamlines and the two-dimensional Riemann problem along streamlines.

Abstract: Systems and methods for generating a model tree structure for a multiphysics modeling system include the acts of transmitting a plurality of selectable physics options for association with at least one of combined systems. An input associated with a selection of at least one of the plurality of selectable physics options is received. One or more selectable study options are transmitted for association with the combined systems. An input associated with a selection of at least one of the one or more selectable study options is received. In response to receiving the input associated with the selection at least one of the one or more selectable study options, a model tree structure is generated using the one or more processing units. The model tree structure includes a plurality of selectable nodes including one or more parent nodes and one or more child nodes. The selectable nodes include fields storing physical quantities and operations for modeling the combined systems.

Abstract: The present invention relates to methods of designing and making perfumed products and perfume raw materials for use in products and perfume raw materials selected by such methods and the use of same.

Abstract: A method for decomposing a layout of an integrated circuit is provided. First, a layout of the integrated circuit is imported, wherein the layout comprises a plurality of sub patterns in a cell region, and a first direction and a second direction are defined thereon. Next, one sub pattern positioned at a corner of the cell region is assigned to an anchor pattern. Then, the sub patterns in the row same as the anchor pattern along the second direction is assigned to the first group. Finally, the rest of the sub patterns are decomposed into the first group and the second group according to a design rule, wherein the sub patterns in the same line are decomposed into the first group and the second group alternatively.

Abstract: According to an embodiment, a method for cell placement in a semiconductor layout is provided. The method includes: providing a first cell having two sides, each side configured as at least one of a source side and a drain side; providing a place-and-route boundary (prBoundary) of the first cell based on the configuration of the two sides of the first cell; providing a second cell having two sides, each side configured as at least one of a source side and a drain side; providing a prBoundary of the second cell based on the configuration of the two sides of the second cell; and placing the first cell and the second cell based on the prBoundary of the first cell and the prBoundary of the second cell.

Abstract: An optical proximity correction (OPC) process is provided. The method comprising receiving a first pattern corresponding to a first structure of a semiconductor structure, and a second pattern corresponding to a second structure of said semiconductor structure. Next, a first OPC process is performed for the first pattern to obtain a revised first pattern, wherein the revised first pattern has a first shift regarding to the first pattern. A second OPC process is performed for the second pattern to obtain a revised second pattern, wherein the second OPC process comprises moving the second pattern according to the first shift.

Abstract: An apparatus for system design verification has a test case module for compiling a test case in a scripting language (such as TCL) and a testbench including the design under test and operating with a Hardware Descriptor Language (such as SystemVerilog). A stimulus generated by the test case module is applied to the testbench through an interface gasket based on ‘C’.

Abstract: According to example embodiments of inventive concepts, a layout design system includes a processor, a storage unit configured to store a layout design, and a stitch module. The layout design includes a first pattern group and a second pattern group disposed in accordance with a design. The first pattern group including a first pattern for patterning at a first time. The second pattern group including a second pattern for patterning at a second time that is different than the first time. The stitch module is configured to detect an iso-pattern of the second pattern using the processor. The stitch module is configured to repetitively designate at least one of the first pattern, which is spaced apart from the iso-pattern by a pitch or more, to the second pattern group using the processor.

Abstract: A method for designing all coverage of valid primer pairs, which satisfy various filtering constraints provided by users with respect to a given sequence database and has validated specificity to given sequences, is provided. By screening all suitable primer pairs present on a given DNA sequence database without omitting any one primer pair and also screening all primers having a coverage of 1 or more as well as primers having a coverage of 1, a user can be allowed to give rankings to the primers in order to easily select the primers having a high success rate in biological experiments from the resulting primers.

Abstract: Provided herein is a system for optimizing the fed-batch hydrolysis of biomass.

Abstract: Methods, systems, and computer program products that predict an individual's treatment outcome from a sampling of a group of patients' biological profiles. Biological profile information is received from patients who had a medical condition and who received a treatment. Treatment outcome information regarding the patients who had the medical condition and who received the treatment is also received. A discriminant analysis-based pattern recognition process is then performed on the biological profile information and the treatment outcome information, thereby generating a model that correlates between the biological profile information and the treatment outcome information. The model can be used for, among other things, predicting treatment outcome for the new patient for the treatment.

Abstract: Methods and compositions related to the selective, specific disruption of multiple ligand-receptor signaling interactions, such as ligand-receptor interactions implicated in disease, are disclosed. These interactions may involve multiple cytokines in a single receptor family or multiple ligand receptor interactions from at least two distinct ligand-receptor families. The compositions may comprise polypeptides having composite sequences that comprise sequence fragments of two or more ligand binding sites. The methods and compositions may involve sequence fragments of two or more ligand binding sites that are arranged to conserve the secondary structure of each of the ligands from which the sequence fragments were taken.

Abstract: The present invention relates to a method and apparatus for genome compression and decompression. In one embodiment of the present invention, there is a method for genome compression, including: selecting from a reference database a reference genome that matches the genome; building an index based on positions of the reference genome's multiple segments in the reference genome; aligning the genome with the reference genome based on the multiple segments so as to identify difference data between the genome and the reference genome; and generating a compressed genome, the compressed genome including at least the index and the difference data. In other embodiments, there is provided an apparatus for genome compression. Further, there is a method and apparatus for decompressing the genome that has been compressed using the above method and apparatus.

Abstract: Apparatus, systems and methods for pre-processing, analyzing, and storing genomic data through a scalable, distributed analysis system across a network is presented.

Abstract: The invention provides methods for identifying rare variants near a structural variation in a genetic sequence, for example, in a nucleic acid sample taken from a subject. The invention additionally includes methods for aligning reads (e.g., nucleic acid reads) to a reference sequence construct accounting for the structural variation, methods for building a reference sequence construct accounting for the structural variation or the structural variation and the rare variant, and systems that use the alignment methods to identify rare variants. The method is scalable, and can be used to align millions of reads to a construct thousands of bases long, or longer.

Abstract: A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit that may be connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits may be arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the bioinformatics analysis on the reads of genomic data. Each subset of the hardwired digital logic circuits may be formed in a wired configuration to perform the one or more steps in the bioinformatics analysis.

Abstract: A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit that may be connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits may be arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the bioinformatics analysis on the reads of genomic data. Each subset of the hardwired digital logic circuits may be formed in a wired configuration to perform the one or more steps in the bioinformatics analysis.

Abstract: A method for estimating a body surface model of a patient includes: (a) segmenting, by a computer processor, three-dimensional sensor image data to isolate patient data from environmental data; (b) categorizing, by the computer processor, a body pose of the patient from the patient data using a first trained classifier; (c) parsing, by the computer processor, the patient data to an anatomical feature of the patient using a second trained classifier, wherein the parsing is based on a result of the categorizing; and (d) estimating, by the computer processor, the body surface model of the patient based on a result of the parsing. Systems for estimating a body surface model of a patient are described.

Abstract: A quality control system for performing quality control checks on pre-scheduled medical imaging studies. The system includes a processor and an interface for receiving electronic orders, each order specifying a medical imaging procedure to be performed at a specified procedure time to produce a study. The processor performs a series of functions for each electronic order. It first determines whether the study to be produced by the specified procedure according to the order requires a quality control check. Then, if the study requires a quality control check, the processor waits until a decision time that is the earlier of the time that the study becomes available for performing a quality control check, and a period of time after the specified procedure time. If, at the decision time, the study is available for performing a quality control check, then the processor performs the quality control check on the study.

Abstract: Systems and methods for remote control and management of medical workstations using an instant messaging infrastructure. A remote client, such as a mobile phone, laptop, tablet, or other computing device, is used to generate instructions or information requests in one or more data packets. The remote client sends the one or more data packets using the instant messaging infrastructure to a medical workstation at another location. A service application in communication with the medical workstation receives the data packets and causes the medical workstation to retrieve the requested information or execute the instruction. The communications between the remote client and the service application are encrypted and signed to ensure secure communications.

Abstract: An Internet based method for assisting in the rapid delivery of medical information direct to the site at which emergency assistance is being performed uses a global database for warehousing patient history information, which is fetched over the Internet on demand. In one embodiment, medical providers use an access code carried by the injured party and without which access is denied. The access code may be carried as a barcode and as an imprinted number on a bracelet or on a card carried by the individual. Patient information is transmitted over a network, either wireline or wireless, the Internet or wide area network, to a computer or personal digital assistant available to emergency personnel. In one embodiment, patient history information access is determined through the use of an access code reader, by entering the patient access code manually or by entering the patient's name as a last resort. Additionally insurance information can be made available to shorten emergency room admission procedures.

Abstract: A system for automating the designation of a disease classification code. In one embodiment, the system includes a rules engine; an input device for entering patient information in communication with the rules engine; an output device in communication with the rules engine; and a database in communication with the rules engine, the database comprising a plurality of rules for providing a disease classification code in response the input patient information, wherein each of the plurality of rules comprises at least one alpha-numeric character corresponding to a digit in the disease classification code; and wherein at least one of the plurality of rules comprises at least one alias rule comprising at least a second alpha-numeric character corresponding to a second digit in the disease classification code.

Abstract: Example medical device data platforms are disclosed herein. In an example, the platform may include at least one integration device to access information originating from a plurality of implantable medical devices manufactured by a plurality of manufacturers and implanted in a plurality of patients. The system may also include an information processor to process the accessed information to generate at least one of patient-oriented information and provider-oriented information. The system may also include at least one communication device providing at least one of a patient portal and a provider portal to provide the patient-oriented information and the provider-oriented information, respectively.

Abstract: Systems and methods for centrally storing relaying medical messages. A system containing databases related to patients and health care providers receives an electronic communication another computer regarding the patient, the current status of the patient, a health care provider, and a procedure which the patient is undergoing (or preparing to undergo). The system analyzes the electronic communication, looks up data associated with the patient and the physician, and communicates a message regarding the procedure to yet another computing device.

Abstract: A healthcare system for personalized healthcare includes a user interface for gathering user related data of nutrition or medicaments consumed by the user, and genetic information of the user. The system also includes a research interface for gathering genetic backgrounds of different illnesses in relation to nutrition or environmental factors, and a health care practitioner interface for gathering user related data of user's health state, personalized treatment or history data. The system provides recommendations of optimal personalized nutrition or medication for the user to reach the optimal nutritive, metabolic and/or health state based on: data of nutrition or medicaments consumed by the user, genetic information of the user, genetic backgrounds of different illnesses in relation to nutrition or environmental factors, user's health state, and personalized treatment or history data of the user. The recommendations are then delivered to the user or health care practitioners via corresponding interfaces.

Abstract: Various of the disclosed embodiments enable adherence to a medication regimen or a healthcare regimen to be monitored using a wearable system. The wearable system can be used to monitor a user's activities by recording activities using a camera that is placed at the anterior part of the user's wrist. The camera, or another sensor, can detect, identify, and verifying movements or gestures of the hand or fingers. A gesture may be a particular hand position, finger movement, or combination of finger movements that are indicative of performance of an activity required as part of a medication or healthcare regimen. The camera can generate a recording of an activity, and the wearable system or a distinct computing device can then analyze the recording and determine compliance to the medication or healthcare regimen based on what action(s), if any, were identified in the recording.

Abstract: A method for creating medical documentation in a hospital information system uses a mobile device, in which a target form is created in the hospital information system as a result of an adapted process for communicating an optimized form definition to a mobile device, which is then used to collect and record the necessary data for the target form using an intermediary data structure called a dummy form. The dummy form is a limited version of the target form (containing a subset of the data of the target form), but behaves in the hospital information system as a target form. A part of the data is captured as digitally recorded multimedia content, which may transcribed later on as text in the target form.

Abstract: A pathogen detection and display system is configured to discover and display the location of substances of interest, particularly pathogens that can spread infection. The detection and display system can be used in healthcare facilities on surfaces, medical equipment and devices, patients, and staff, for example.

Abstract: Disclosed are embodiments of methods and systems for predicting a health condition of a first human subject. The method comprises extracting a historical data including physiological parameters of one or more second human subjects. A latent variable is determined based on an inverse cumulative distribution of a transformed historical data, determined by ranking of the historical data. Further, one or more parameters of a first distribution, deterministic of health conditions in the historical data, are determined based on the latent variable. For each physiological parameter, a random variable is sampled from a second distribution of the physiological parameter based on the one or more parameters. Further, based on the random variable, the latent variable is updated. Thereafter, the one or more parameters are re-estimated based on the updated latent variable. Based on the first distribution a classifier is trained to predict the health condition of the first human subject.

Abstract: A diagnostic imaging support system that enables confirmation of abnormalities in anatomical regions of a brain includes capturing images of the brain, specifying regions in the captured images that correspond to the anatomical regions, searching a medical database for similar cases based information associated with the specified regions, and displaying the results of the search.

Abstract: The invention relates to the method and system for smart health management service by using an automation platform installed in smart phones in order to provide smart phone users with tailored and self-supporting service system. In order to acquire goods and services, which provide solutions to problems, either on a regular or irregular basis, self-maintenance and control, healthy life management, financial management, self-management and planning, the program causes the Server automatically to perform the method and system that comprises transmitting the personal characteristics information related to wellness and health with ease measurement and assessment, and quality control.

Abstract: An automatic locking system for a medical treatment device helps to ensure that an assistant is present during treatment of a patient. Among the features disclosed biometric authentication to verify that a trained assistant is present, a presence detector to ensure the assistant is continuously present during treatment, and warning and recovery processes that allow intermittent lapses in the continuous presence of the assistant.

Abstract: A system that incorporates teachings of the present disclosure may include, for example, an avatar engine having a controller to retrieve a user profile of a user, present the user an avatar having characteristics that correlate to the user profile, detect one or more responses of the user during a communication exchange between the user and the avatar, identify from the one or more responses a need to determine a medical status of the user, establish communications with a medical diagnostic system, receive physiological information associated with the user, submit the physiological information to the medical diagnostic system, receive from the medical diagnostic system a diagnostic analysis of the physiological information, and present the diagnostic analysis to at least one of the user and a medical agent of the user, wherein the user is presented the diagnostic analysis by way of the avatar. Other embodiments are disclosed.

Abstract: A patient respiratory and cardiovascular monitoring and evaluation system broadly comprising a wearable respiratory and cardiovascular monitoring garment, a number of sensors and microphones, and a patient computing device. The sensors may be positioned on various locations of the wearable garment for sensing heat rate, blood pressure, and thoracic impedance, among other vital health information. The microphones may similarly be positioned on various locations of the wearable garment for sensing lung and heart auscultations. The wearable garment may be worn close to the patient's chest wall for improving sensor and microphone data while retaining patient mobility. The patient computing device runs a monitoring application thereon and includes a graphical user interface having a number of virtual inputs for allowing the patient to initiate self-monitoring sessions and manage the signals and computer data received from the sensors and microphones.

Abstract: The present invention provides a method of determining a treatment program for a subject. The method includes obtaining subject data representing the subject's condition. The subject data is used together with a model of the condition, to determine system values representing the condition. These system values are then used to determining one or more trajectories representing the progression of the condition in accordance with the model. From this, it is possible to determine a treatment program in accordance with the determined trajectories.

Abstract: A method for subject-specific assessment of neurological disorders, the method includes receiving 3D image data representative of a subject's brain and identifying subject-specific anatomical structures in the 3D image data. A subject-specific model for electrical dynamics is created based on the 3D image data and the subject-specific anatomical structures and one or more functional indicators of neurological disorder are computed using the subject-specific model for electrical dynamics.

Abstract: Computer-implemented methods are disclosed for assessing the effect of musculoskeletal activities on disease and/or clinical events, the method comprising: receiving a patient-specific vascular and musculoskeletal model of a patient's anatomy, including at least one vessel of the patient; receiving at least one characteristic of the patient's musculoskeletal activity; generating or updating a computational anatomic vascular and musculoskeletal model of the patient's anatomy based on the received at least one characteristic of musculoskeletal activity; performing at least one of a computational fluid dynamics analysis or a structural mechanics simulation on the computational anatomic vascular and musculoskeletal model; and estimating at least one of the patient's risk of disease or clinical events based on the performed computational fluid dynamics analysis and/or structural mechanics simulation. Systems and computer readable media for executing these methods are also disclosed.

Abstract: Systems and methods are disclosed for assessing tissue function based on vascular disease. One method includes receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patient's tissue; receiving a patient-specific vascular model generated from patient-specific imaging of at least a portion of a patient's vasculature; receiving an estimate of blood supplied to a portion of the patient-specific anatomic model; and determining a characteristic of the function of the patient's tissue using the estimate of blood supplied to the portion of the patient-specific anatomic model.

Abstract: The present invention is directed to computer based pharmacokinetics systems, such as. web-based pharmacokinetics systems, and their use to predict a dose and a dosing interval for a patient in need of a clotting factor therapy.

Abstract: Systems, methods, and computer program products for recording and monitoring pain are disclosed. A device may record a date and time corresponding to a pain entry, a pain type corresponding to the pain entry, and a pain intensity corresponding to the pain entry. The device may further record a pain location on a body corresponding to the pain entry. The device may also display the pain entry. In various embodiments, the device may display a graphical pain representation superimposed over the pain location on the body. The device may also read an input encircling the pain location on the body. The device may further display a plurality of pain entries in a plot relative to time.

Abstract: Method, systems, and devices for designing a test molecule are disclosed. An example method includes using a molecular simulator to generate sets of simulation data. Each set of simulation data may include simulation data indicative of simulated locations in a solvent of (i) molecules of a reference molecule and (ii) molecules of one of M test molecules. The method may also include determining a probability of contact between an a species and a ? species for each set of simulated data. A contact may occur when a particle of the ? species is within a range of radials distances from a particle of the ? species. Each of the a species and the ? species may be one of the reference molecule, the solvent, or one of the M test molecules. The method may further include determining a simulation result based on at least one probability of contact.

Abstract: A computational systems pharmacology framework consisting of statistical modeling and machine learning based on comprehensive integration of systems biology data, including drug target data, protein-protein interaction (PPI) networks, and gene ontology (GO) annotations, and reported drug side effects, can predict drug toxicity or drug adverse reactions (ADRs). Biomolecular network and gene annotation information can significantly improve the predictive accuracy of ADR of drugs under development. The use of PPI networks can increase prediction specificity, and the use of GO annotations can increase prediction sensitivity.