Abstract: A method of manufacturing an absorbent article including a fastening system having a primary fastening system and a secondary fastening system is disclosed. In one embodiment, the method can include providing an absorbent assembly, providing a web of primary second fastening component material, and providing a carrier web including a secondary first fastening component material. The method can further include coupling the carrier web to the web of primary second fastening component material to form a composite web, cutting the composite web to form a discrete composite web component, and coupling the discrete composite web component to the outer cover of the absorbent assembly, with the discrete composite web component forming the primary second fastening component of the primary fastening system and the at least one secondary first fastening component of the secondary fastening system.

Abstract: A composite web, with elastic and inelastic regions, is formed to separated or punched into diaper closure elements. The composite web includes nonwoven web which forms a first outer side of the composite web. On the composite web are disposed spaced-apart, elastically stretchable foil strips. A nonwoven material covers the elastically stretchable foil strips on a second outer side of the composite web. At least one inelastic strip of a hook material bridges a region between two adjacent, elastically stretchable foil strips. The nonwoven material overlaps edges of the strip of hook material. The strip of hook material has projections on the edges thereof that are overlapped by the nonwoven material. The projections extend into the nonwoven material.

Abstract: A rectangular first sheet has a right side, a wrong side, and side edges. A pair of vertical straps are fabricated of an essentially inextensible strapping cord. Selective stitching couples each vertical strap to the wrong side of the first sheet with each vertical strap extending beyond the first sheet and parallel with and spaced a distance from an adjacent side edge. A pair of horizontal straps are fabricated of an essentially inextensible strapping cord. Additional selective stitching couples each horizontal strap to the wrong side of the first sheet with each end of each horizontal strap extending beyond the first sheet. A loop is formed at each end of each strap to create handles. A second sheet is in a rectangular configuration. Peripheral stitching couples the first sheet and the second sheet with the straps between the sheets.

Abstract: A hip distractor includes a pair of distractor members and a support configured to be fastened to a surgical table. The support includes at least two mounts for coupling to a pair of joints that couple the distractor members to the support. Another hip distractor includes a pair of distractor assemblies that are configured to apply a distraction load to a patient. Each of the assemblies includes a joint for coupling the corresponding assembly to a surgical table. The joint permits vertical and horizontal angular adjustment of the corresponding assembly. A method of distracting a hip includes coupling a patient's legs to a pair of distractor assemblies and simultaneously adjusting a vertical angle and a horizontal angle of at least one of the distractor assemblies.

Abstract: A transport carriage for transport for transport of a patient support and/or an operating table column of an operating table includes a chassis which is connectable with the patient support and/or with the operating table column. The chassis includes a first longitudinal beam and a second longitudinal beam arranged at a distance thereto. The first and second longitudinal beams form a fork-shaped opening. At least one castor which is pivotable about a swiveling axis is arranged at each longitudinal beam forming the fork-shaped opening. The transport carriage includes at least one delimiting unit for delimiting the swiveling movement of at least one of the castors about its swiveling axis. This delimitation can be automatically revoked upon lifting the base of the operating table.

Abstract: A femoral support system includes a plate configured to support the pelvis of a patient on a table. In addition, the system includes a femoral support pivotally coupled to the plate and configured to support the thigh of the patient.

Abstract: A burial system and method includes a container with an outer shell surrounding an interior containment space where the container is configured to retain biological remains in the interior containment space. A pressure relief valve is connected with the container where the pressure relief valve is a one-way valve for release of pressure from the interior containment space. An input valve is connected with the container where the input valve is a one-way valve for the introduction of material to the interior containment space. At least one sensor device is connected with the container where the at least one sensor device monitors and obtains data from the interior containment space and the exterior of the container. A management information system is connected with the container where the management information system maintains real time and historical data of the container.

Abstract: A portable active fluid-powered ankle foot orthosis. A lower leg mount and a foot bed are pivotally coupled at or proximate to an ankle position. A fluid powered rotary actuator is configured to receive power from a wearable fluid power source and provide controlled force and resistance to aid or inhibit relative rotation of the foot bed and the lower leg mount. An integral controller is provided for receiving data from sensors and controlling the fluid powered rotary actuator to actively assist gait of a user.

Abstract: A walking assistance device configured to permit the independent movement of an individual via simulated weight reduction is described. The device is configured to partially suspend a portion of a user's weight via a seat-lifting system, facilitating the movement of a user with experiencing difficulty walking without assistance. The system of the device preferably employs a seat, a hydraulic or electric seat-lift mechanism, a seat restraint, a frame, wheels, a brake system, and a power source. The seat-lift mechanism is configured to rise and lower the seat, enabling the user to control the percentage of weight lifted, while the feet of the user remain in partial contact with the floor. The frame forms the structure and support of the device, and is configured to move laterally via wheels on the bottom of the frame of the device.

Abstract: The apparatus for immobilizing and treating a subject includes a suitable apparatus for performing mechanical CPR secured to an immobilization casing. The airtight flexible casing is secured to the apparatus for performing CPR, the casing having variable rigidity which varies as a function of the amount of air within the casing. Two or more slots through the casing permit passage of one or more elements of the CPR apparatus to pass through the casing. One or more incompressible windows may be included in the casing to optimize the performance of mechanical CPR by permitting one or more elements of the subject's skeleton to contact the CPR apparatus. A device for evacuating the air from within the flexible casing to control the rigidity of the casing is included within the CPR apparatus.

Abstract: A medical instrument configured to cover at least a mouth section of a medical container that includes a container body with the mouth section at a distal end and a sealing member that seals the mouth section, includes: a cap comprising a cylindrical body; an adapter; and a proximal-end side structure body. The medical device is configured such that, when screw-engagement between a second cap-side screw-engaged portion and a proximal-end side screw-engaged portion is released by rotating the cap around a center axis, the adapter moves in the proximal-end direction while being prevented from rotating by a guide portion, thereby allowing an adapter-side screw-engaged portion to be detached from a first cap-side screw-engaged portion, and further allowing a hollow needle to penetrate the sealing member so that an inside of the container body communicates with an outside via the hollow needle.

Abstract: The present invention provides a medical safety device for holding a container. The medical safety device is used to hold the container while extracting liquid by a syringe from the container. The medical safety device includes a main body having an opening for an interior. The interior has a retention space configured for retaining a container. In addition, the main body includes a plunger having a retention surface configured for contacting and retaining a container in the retention space. The plunger slides up and down within the retention space. Two handles are affixed to opposing sides of the main body. The plunger and retention surface applies force to the container positioned within the retention space sufficient to hold the container in place within the retention space. The plunger may be biased down into the retention space by a spring attached to the plunger.

Abstract: The present invention relates to a medical device (1, 100) comprising a first container (10, 110) holding a first medium and defining a general axis, a second container (20, 120) holding a second medium, and fluid connection means (50, 150) for establishing fluid connection between the first container (10, 110) and the second container (20, 120), the fluid connection means (50, 150) being arranged at least partially between the first container (10, 110) and the second container (20, 120). The device further comprises a cover receiving portion (42, 42) and a cover (4, 104) removably mounted thereon to shield at least an operable portion of the first container (10, 110).

Abstract: A vial adapter may include first and second sections each having first and second ends joined to form a collar having a central passage in which a neck of a vial may be disposed. Each collar section may have a hook formed at each end, the hooks joined to join the collar sections together. The first ends may have at least one tab depending therefrom and the second ends may have at least one indent formed therein, the tab disposed within the indent with the hooks joined to each other. In addition or instead, the collar may have an inner surface with a groove separating the collar into first and second regions on opposing axial sides of the groove. The first and second regions may be deformable axially into the groove when the collar is acted upon with the neck of the vial in the central passage.

Abstract: A method of feeding breast milk to an infant includes providing a spout pouch having a spout, providing a plurality of adapters configured to couple to the spout pouch, coupling the spout of the spout pouch to a first adapter, coupling the first adapter to a breast pump, operating the breast pump to express breast milk into the spout pouch, so that the spout pouch collects the expressed breast milk, coupling a second adapter to the spout of the spout pouch, and coupling the second adapter to a nipple, so that expressed breast milk flows from the spout pouch to the nipple. Other systems, methods, and components are also provided.

Abstract: Teething device for an infant, with a substantially arc-shaped and elastically deformable teething element having two free end areas spaced apart from each other in an unloaded rest position, wherein the teething element forms a free gap between the end areas in the rest position and is substantially circular, and the arc-shaped teething element substantially simulates the shape of the jaw in such a way that, when it is inserted into the mouth and is substantially congruent with the jaw, the end areas are arranged in the area of the molars in the rest position of the teething element, wherein the free gap has an opening angle of between 15° and 35°, measured from the internal apex of the opening, and the arc-shaped teething element is elastically deformable in such a way that the two end areas can be arranged at least partially overlapping each other in a securing position.

Abstract: Example embodiments of the present invention utilize long term anti-microbial/bacteriostatic compounds that are dispersed throughout a tooth restoration material as a means to reduce or eliminate recurrent decay between the tooth restoration material and tooth structure. More specifically, the present invention utilizes metals, metal oxides, and metal salts, insoluble bacteriostatic organic compounds, soluble bacteriostatic organic compounds, and organometallic compounds as long term anti-microbial/bacteriostatic compounds that are dispersed throughout the tooth restoration material as a means to reduce or eliminate recurrent decay between the tooth restoration material and tooth structure.

Abstract: A web material containing one or more active agents and methods for making same are provided.

Abstract: An aqueous structured surfactant composition comprising water, one or more sulfate free anionic surfactants, one or more hydroxysultaines and one or more amphodiacetates, which is capable of suspending water insoluble or partially water soluble components. A sulfate-free structured liquid surfactant composition for use in personal care formulations allows for high level of vegetable oil and/or fragrance oil in end formula without negatively affecting stability and foam properties.

Abstract: A co-modified organopolysiloxane represented by General Formula (1): R2R12SiO(R12SiO)nSiR12Q, and a surfactant/dispersing agent, emulsifier for a water-in-oil emulsion, external use preparation and cosmetic composition comprising the same. In the formula, the R1 groups are monovalent hydrocarbon group having 1 to 12 carbon atoms, R2 is a monovalent hydrocarbon group having 13 to 30 carbon atoms, and Q is a sugar alcohol group-containing organic group or a diglycerin derivative group having an average number of repetitions of a glycerin unit of 1.1 to 2.9, n is a number in a range of 0 to 100.

Abstract: A capsule slurry including at least one coacervated capsule and at least 10 wt % humectant is disclosed. The humectant may be sorbitol, glycerin, polyethylene glycol, propylene glycol, xylitol, erythritol and/or betaine.

Abstract: The present invention relates to a cosmetic composition comprising: (i) boron nitride; and (ii) one or more kinds of inorganic powders selected from the group consisting of cerium oxide, titanium oxide, talc, aluminum oxide, iron oxide, zinc oxide and mica. UVA, UVB and near-IR may be simultaneously screened by applying the cosmetic composition.

Abstract: The present invention relates to a single phase temperature management composition. The composition includes from 0.01% to 10% by weight of a neurosensory agent and from 0.01% to 30% by weight of an antiperspirant component. The composition also includes a polar carrier where the polar carrier includes water and monohydric alcohol. The ratio of water to monohydric alcohol ranges from 0.0625:1 to 1.5:1. The compositions of the invention have a viscosity at room temperature of less than 2500 centipoise.

Abstract: A cosmetic composition comprising a safe and effective amount of a skin care active; a safe and effective amount of a skin lightening agent; a safe and effective amount of bisabolol; and a safe and effective amount of a glycerol ether of aliphatic alcohol, wherein the ratio of bisabolol to glycerol ether of aliphatic alcohol is from 2:1 to 1:15.

Abstract: Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.

Abstract: A skin care formulation which provides a skin lightening effect virtually immediately upon topical application to the skin and which includes a combination of one or more poly(ethylene) oxides and an acrylic emulsion polymer film former comprising emulsion polymers derived from one or more ethylenically unsaturated monomers.

Abstract: A cereal extract is cosmetically used and obtained by at least one polar solvent. This cereal extract is used as a slimming agent in a slimming cosmetic composition. The cosmetic use makes it possible to achieve an effective slimming cosmetic care with a natural, nontoxic slimming agent.

Abstract: Disclosed herein is a cosmetic composition containing, as an active ingredient, a mixture of extracts of honey-roasted Adenophora triphylla var. japonica Hara and honey-roasted Angelica tenuissima Nakai, processed using a medicinal herb processing technique, and of extracts of medicinal herbs such as Lycium chinense Mill or Paeonia suffruticosa, and thus shows excellent antioxidant and skin-moisturizing effects.

Abstract: The present invention relates to a method for extracting phenolic compounds with low molecular weights from olive fruit water; the invention also relates to compositions enriched with phenolic compounds including at least 40% of dry matter, said dry matter consisting of at least 30% hydroxytyrosol; the invention also relates to a method for drying said compositions by spraying using grape polyphenol extracts as a drying medium as well as to powders titrated with phenolic compounds of olives and grapes obtained after drying.

Abstract: A nano freeze dry process of preparation for a cosmetic composition having a bioactive agent for providing an anti-aging effect on a skin, comprising the steps of: placing the cosmetic composition having a bioactive agent into a capsule container; and nano freeze drying the cosmetic composition by: freezing the cosmetic composition in the capsule container at ?170° C.; increasing the temperature to ?85° C. and allowing sublimation under vacuum condition; then increasing the temperature to 35° C.; and vacuum drying to obtain a final product, wherein a volume of the cosmetic composition remains unchanged after the process, a water content of less than 5% is inside the final, at least 80% of bioactivity of the cosmetic composition is retained, and significant anti-aging effect is observed after a two-day treatment.

Abstract: Methods and compositions for treatment of halitosis are provided; devices and methods, such as a palatal patch, including a tablet or strip having a bioadhesive component and active ingredients are further provided; the bioadhesive component allows for the palatal patch to be attached to the upper palate and for the active component to be released into the oral cavity and/or GI tract; compositions for the active ingredient include composition for treatment of halitosis, anti-acids, vitamins, anti-smoking agents, etc; an herbal composition for treatment of halitosis including Echinacea, Lavender, Mastic Gum and Sage and a method of manufacturing a medicine from the herbal composition are provided as well; a device for delivery of the palatal patch to the upper palate including a housing and piston is also provided.

Abstract: The present invention generally relates to compositions and methods for topical or transdermal delivery, e.g., for affecting mood states. In some cases, the composition may include nitric oxide and/or peptides. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

Abstract: Described herein are implantable composites, articles comprising the composites, implant devices comprising the composites, and methods of making and using same, including point of use methods.

Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.

Abstract: Disclosed herein are non-irritating ophthalmic emulsion compositions useful for treating ocular disorders including dry eye. More specifically, the ophthalmic compositions disclosed herein combine a high HLB surfactant and a low HLB surfactant together with an omega-3 fatty acid-containing oil having non-polar aliphatic side chains to form a therapeutic non-irritating eye drop.

Abstract: The present invention provides an ocular implant of siRNA complexed with a transfection agent such as cationic lipids and short cell penetration peptides, wherein the complex is associated with a biocompatible polymer. The biocompatible polymer includes a polymeric matrix configured to release the complex into the eye of a patient at therapeutic levels for a time sufficient to treat an ocular condition or disease.

Abstract: Single-serve containers for use in brewing a cannabis-based beverage are described, as are methods for preparing a single-serve container configured for receipt in a single-serve brewing machine. The method includes: adding a processed cannabis product to the single-serve container; adding, to the single-serve container, at least one of an extraction or flavoring agent; and sealing the single-serve container.

Abstract: The present invention relates to a hydrogel matrix comprising cartilage-forming cells wherein alginate, chitosan and cartilage-forming cells are mixed and subsequently polymerized into beads.

Abstract: The present invention is directed to novel formulations and methods for the improved delivery and administration of hydrophobic therapeutic compounds that are substantially insoluble and/or susceptible to precipitation in aqueous solution at physiological pH, including, e.g., growth and differentiation factor-5 and related proteins. Many therapeutic compounds are hydrophobic at physiological pH levels.

Abstract: Nanolipidic Particles (NLPs) having average mean diameters of 1 nm to 20 nm are made from a precursor solution. NLPs can be loaded with a desired passenger molecule. Assemblies of these particles, called NLP assemblies, result in a vehicle population of a desired size. Single application or multifunction NLP assemblies are made from the loaded NLPs and range in size from about 30 to about 200 nm. A method of using preloaded NLPs to make larger carrier vehicles or a mixed population provides increased encapsulation efficiency. NLPs have application in the cosmetics, pharmaceutical, and food and beverage industries.

Abstract: Described herein are compositions comprising at least one Omega-3 fatty acid ester and at least one surface active agent; wherein the compositions form micelles when in contact with an aqueous medium. Also provided is a method of administering to a subject a composition comprising at least one Omega-3 fatty acid ester and at least one surface active agent, wherein the at least one Omega-3 fatty acid ester forms micelles when in contact with an aqueous medium, and the bioavailability of the at least one Omega-3 fatty acid ester is substantially independent of a food effect. The compositions are useful for treating cardiovascular conditions or disorders in a subject and for reducing side effects associated with the ingestion of Omega-3 fatty acid esters. Described are also various dosage forms for administering the compositions and use of the compositions in functional foods. Provided herein are also kits with instructions on how to administer the compositions.

Abstract: A steam-sterilizable aerosol valve has a valve body of polymeric material such as polyphenylene sulfone (PPSU) having an HDT (heat deflection temperature) at 1.8 MPa stress in the range of 200-275° C. Such a valve has the ability to survive steam sterilization without significant degradation of properties or appearance.

Abstract: Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.

Abstract: The invention relates to novel particulate drug-delivery systems based on a polymer support containing at least one linear, branched or cross-linked polymer in a fraction of over 50 percent by weight in relation to the total weight of the support. The system is characterized in that at least one signal substance for transport through a biological barrier and at least one active ingredient are stored, the support, signal substance and active ingredient having no covalent links and no active-ingredient specific and signal substance specific coordinative links between one another.

Abstract: The present invention relates to a solid pharmaceutical dosage form comprising dolutegravir, a method of its preparation and its use in the treatment of an HIV infection.

Abstract: A method of preparing rosemary nanoparticles includes providing a solution including rosemary extract, spraying the rosemary extract solution into boiling water under ultrasonic conditions to produce a sonicated mixture, and freeze-drying the sonicated mixture to produce rosemary nanoparticles. The rosemary nanoparticles and encapsulated rosemary nanoparticles with polymers can have a particle size of about 69 nm to about 99 nm. The rosemary nanoparticles and encapsulated rosemary nanoparticles with polymers can be prepared without the use of metals.

Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum compound having a heterocycle ligand. Cabazitaxel-platinum nanoparticles are disclosed herein, as well as methods of making and using the same.

Abstract: C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including treating and preventing neurodegenerative diseases such as Alzheimer's disease.

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

Abstract: There are provided methods for treating an inflammatory diseases chosen from inflammatory bowel diseases, asthma, acute respiratory distress syndrome, chronic obstructive pulmonary disease, acute lung injury, bronchopulmonary dysplasia, cystic fibrosis, bronchitis, bronchiolitis, arthritis, osteoarthritis, ankylosing spondylitis and rheumatism. The method comprise administering to a subject in need thereof an effective amount of at least one lipid and an effective amount of at least one compound chosen from compounds of the present disclosure. Such compounds are polyunsaturated fatty acid monoglycerides or derivatives thereof.