Patents Issued in November 29, 2016
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Patent number: 9505998Abstract: A method and system for processing an input fuel gas and steam to produce separate CO2 and output fuel gas streams. The method comprises the steps of using a decarbonizer segment for reacting at least a solid sorbent with the fuel gas and steam to remove carbon from the input fuel gas and to produce the output fuel gas stream in an exhaust gas from the decarbonizer; using a calciner segment for reacting the solid sorbent from the decarbonizer segment therein to release the CO2 into the CO2 gas stream; wherein CO2 partial pressures and temperatures in the decarbonizer and calciner segments respectively are controlled such that the temperature in the decarbonizer segment is higher than the temperature in the calciner.Type: GrantFiled: July 20, 2015Date of Patent: November 29, 2016Assignee: Calix LimitedInventors: Mark Geoffrey Sceats, Julian Westley Dinsdale
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Patent number: 9505999Abstract: A method to reduce formation of waste water in coal gasification and syngas pretreatment process by increasing the salinity of the waste water thereby reducing the overall volume of waste water formed.Type: GrantFiled: June 13, 2015Date of Patent: November 29, 2016Inventor: Wanwang Peng
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Patent number: 9506000Abstract: Method of marking a hydrocarbon liquid includes: adding thereto, a tracer compound of Formula I: wherein, each A is independently selected from the group consisting of (i) a phenyl group, (ii) a phenyl group substituted with one or more halogen atoms, an aliphatic group or a halogenated aliphatic group, (iii) a partially or fully halogenated alkyl group or (iv) a linear branched or cyclic C1-C20 alkyl group, and each B is independently selected from the group consisting of a (i) phenyl, (ii) phenylmethyl group, (iii) a cyclohexyl group, (iv) a cyclohexylmethyl group, (v) a substituted phenyl or phenylmethyl group in which the benzene ring is substituted by at least one substituent selected from the group consisting of a fluorine atom, a partially or fully halogenated alkyl group and a linear, branched or cyclic C1-C20 alkyl group or (vi) a linear, branched or cyclic C1-C20 alkyl group.Type: GrantFiled: January 4, 2013Date of Patent: November 29, 2016Assignee: JOHNSON MATTHEY PUBLIC LIMITED COMPANYInventors: Vincent Brian Croud, Ian Stuart Edworthy, Duncan McCallien
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Patent number: 9506001Abstract: The invention provides an emulsification technique which permits the formation of functional oil/water or functional granules/water emulsion systems excellent in thermal stability and long-term stability and which can attain the emulsification independent of required HLB of the functional oils, and the dispersion independent of surface properties of the functional granules. In the technique is used an emulsifying dispersant comprising, as the main component, vesicles formed from an amphiphilic substance capable of self-assembly or an emulsifying dispersant comprising single particles of a biopolymer as the main component. The particles made from amphiphilic substances capable of self-assembly are used.Type: GrantFiled: March 29, 2005Date of Patent: November 29, 2016Assignee: KANAGAWA UNIVERSITYInventors: Kazuo Tajima, Yoko Imai, Teruo Horiuchi
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Patent number: 9506002Abstract: A waste processing system to dry, condense and sterilize waste materials to a final product for reuse enhances efficiency while eliminating greenhouse gas emissions. The system includes a mixing chamber with blades to shred the waste materials, a pressurized chamber operably connected to the mixing chamber and including a heating ducting operated by a control system, the control system able to heat the waste materials received by the pressurized chamber from the mixing chamber to a temperature within a predetermined temperature range for a time period to eliminate moisture from the waste materials, and an auger housed within the pressurized chamber and operably connected to an auger motor. The auger extrudes the heated waste materials through an outlet in the pressurized chamber to form the final product for reuse.Type: GrantFiled: October 10, 2014Date of Patent: November 29, 2016Assignee: VALENCIA PARTNERS, LLCInventor: John Wishard
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Patent number: 9506003Abstract: The invention relates to lubricants for magnetic recording media, and in particular, to such lubricants containing cyclotriphosphazene. Methods for preparing the lubricants are also disclosed.Type: GrantFiled: August 7, 2013Date of Patent: November 29, 2016Assignee: Agency for Science, Technology and ResearchInventors: Jianwei Xu, Rong Ji, Xiaobai Wang, Ching Mui Cho, Yan Xuan Angeline Tan, Chaobin He, Huiqing Xie, Wen Huei Jack Tsai
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Patent number: 9506004Abstract: A slide member provided with a base, an impregnated layer, and a resin layer. The base made of metal or ceramic. The impregnated layer is defined on a surface portion of a sliding side of the base by forming a recess on the base. The resin layer impregnates the impregnated layer so as to cover a sliding side surface of the base.Type: GrantFiled: March 10, 2015Date of Patent: November 29, 2016Assignee: DAIDO METAL COMPANY LTD.Inventors: Hiroichi Matsuhisa, Hiroshi Yoshimura, Makoto Shito
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Patent number: 9506005Abstract: The present invention relates to a non-hydroxide grease composition comprising a base oil and a thickener which comprises amorphous hydrophilic silicon oxide particles and one or more metal salts of different organic acids, wherein the silicon oxide particles have a BET specific surface area of at least 50 m2/g and wherein the amount of the metal salt(s) is 4-25% by weight, based on the total weight of the grease composition. The present invention further relates to a method for manufacturing said grease composition and the use of said grease composition for lubricating a bearing and in couplings and gearings.Type: GrantFiled: August 3, 2010Date of Patent: November 29, 2016Assignee: AKTOEBOLAGET SKFInventors: Sébastien David, Franciscus Catherina Martinus Fiddelaers
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Patent number: 9506006Abstract: The present invention provides a composition and a concentrate, comprising: (a) a major amount of an oil of lubricating viscosity, (b) a quaternary ammonium salt of a hydrocarbyl-substituted acylating agent condensation product, and (c) an optional amount of a succinimide dispersant different from (b), and a use of the composition or concentrate for lubricating an engine. In a further embodiment, the invention provides the use of a quaternary ammonium salt of a hydrocarbyl-substituted acylating agent condensation product as a dispersant in a lubricating composition, and as a synergistic dispersant combination with a different succinimide dispersant.Type: GrantFiled: June 18, 2012Date of Patent: November 29, 2016Assignee: The Lubrizol CorporationInventors: Joanne L. Jones, Dean Thetford, David J. Moreton, Matthew D. Gieselman
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Patent number: 9506007Abstract: This invention describes low sulfur marine distillate fuel trunk piston diesel engine lubricating oil compositions, as well as methods for operating trunk piston engines by fueling the engines with a low sulfur marine distillate fuel trunk piston diesel engine lubricating oil composition.Type: GrantFiled: November 14, 2014Date of Patent: November 29, 2016Assignee: Chevron Oronite Technology B.V.Inventor: Wilhelmus Petrus Antonie Van Houten
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Patent number: 9506008Abstract: A method for improving fuel efficiency and reducing frictional properties, while maintaining or improving deposit control, in an engine lubricated with a lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition including a lubricating oil base stock as a major component, and a combination of (i) a friction modifier mixture and (ii) a detergent, as a minor component. Fuel efficiency and friction reduction properties are improved and deposit control is maintained or improved as compared to friction reduction properties and deposit control achieved using a lubricating engine oil containing a minor component other than the combination of the friction modifier mixture and detergent. A lubricating engine oil having a composition including a lubricating oil base stock as a major component, and a combination of (i) a friction modifier mixture and (ii) a detergent, as a minor component.Type: GrantFiled: March 19, 2014Date of Patent: November 29, 2016Assignee: ExxonMobil Research and Engineering CompanyInventors: Dennis A. Gaal, Erik Herz, Mrugesh Nilesh Patel, Douglas Edward Deckman, Smruti A. Dance
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Patent number: 9506009Abstract: A method for improving wear control, while maintaining or improving deposit control and fuel efficiency, in an engine lubricated with a lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition including a lubricating oil base stock as a major component, and at least one dispersant and a mixture of viscosity modifiers, as minor components. The at least one dispersant is a polyalkenyl succinic derivative and at least one viscosity modifier is a vinyl aromatic-containing polymer or copolymer. A lubricating engine oil having a composition including a lubricating oil base stock as a major component, at least one dispersant and a mixture of viscosity modifiers, as minor components. The lubricating engine oils are useful in internal combustion engines including direct injection, gasoline and diesel engines.Type: GrantFiled: May 29, 2014Date of Patent: November 29, 2016Assignee: ExxonMobil Research and Engineering CompanyInventors: Smruti A. Dance, Ahmed F. Abou El Enein, Benjamin D. Eirich, Kevin J. Kelly, Douglas E. Deckman
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Patent number: 9506010Abstract: A lubricating oil composition is provided by mixing a lubricant base oil with components (A) to (C) as follows: (A) a tertiary amine represented by a formula (1) below, where: R1 is a hydrocarbon group having 16 to 22 carbon atoms and R2 and R3 independently represent a hydrocarbon group having 1 to 2 carbon atoms, R2 and R3 being adapted to form a heterocyclic ring with terminal ends thereof being bonded; (B) at least one of acid phosphate and acid phosphite; and (C) at least one of metal sulfonate, metal phenate and metal salicylate.Type: GrantFiled: September 15, 2010Date of Patent: November 29, 2016Assignee: IDEMITSU KOSAN CO., LTD.Inventor: Keiichi Narita
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Patent number: 9506011Abstract: The present invention provides a method, composition and product by process of pomegranate seed oil. The present invention provides a novel method for the preparation of pomegranate seeds and the subsequent extraction, stabilization and deodorization of pomegranate seed oil. The process maintains key beneficial components of pomegranate seed oil. Effective processing parameters for separating, drying, cleaning, flaking, obtaining the oil from seeds, stabilizing through refining and bleaching and deodorizing the oil are described.Type: GrantFiled: June 24, 2015Date of Patent: November 29, 2016Assignee: POM Wonderful, LLCInventors: Steve Anderson, Mark Dreher, Rick Green
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Patent number: 9506012Abstract: The present invention provides a method of using, as a fragrance component, a compound that is excellent in fragrance retention and that has green floral and fruity like odors, which are useful as fragrances, and a fragrance composition with sweetness and voluminousness containing the compound. The present invention relates to a fragrance composition containing 2-n-pentyl cyclopentanone oxime and a method of using 2-n-pentyl cyclopentanone oxime as a fragrance component.Type: GrantFiled: May 20, 2014Date of Patent: November 29, 2016Assignee: Kao CorporationInventors: Tomotaka Matsumoto, Takashi Aoki, Takahiro Hirose, Shoichi Tahara
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Patent number: 9506013Abstract: Alkoxylated fatty ester compositions are disclosed. In one aspect, the compositions comprise a reaction product of a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives with one or more alkylene oxides in the presence of an insertion catalyst to give an alkoxylated fatty ester. In another aspect, the metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or its ester derivative is reacted with a glycol ether or a glycol ether alkoxylate, to give an alkoxylated fatty ester. In yet another aspect, the metathesis-derived C10-C17 monounsaturated acid or octadecene-1,18-dioic acid is reacted with one or more alkylene oxides to give a fatty acid alkoxylate, followed by etherification of the fatty acid alkoxylate.Type: GrantFiled: October 13, 2015Date of Patent: November 29, 2016Assignee: Stepan CompanyInventors: Dave R Allen, Marcos Alonso, Randal J Bernhardt, Aaron Brown, Kelly Buchek, Sangeeta Ganguly-Mink, Brian Holland, Andrew D Malec, Ronald A. Masters, Dennis S. Murphy, Patti Skelton, Brian Sook, Michael Wiester, Patrick Shane Wolfe
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Patent number: 9506014Abstract: The present invention relates to a quick rinse detergent cleaner. The detergent contains high levels of salt that immediately collapse soap bubbles, so that less rinsing (and re-rinsing) of utensils is required. This allows for greater portability and applications relative to existing cleaning solutions.Type: GrantFiled: May 4, 2016Date of Patent: November 29, 2016Inventors: Mohamed Rustom Ashry, Mohammed Ragab Elshaer
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Patent number: 9506015Abstract: Method for treating a textile under industrial and institutional fabric care conditions to impart softness within a single wash and/or rinse cycle are disclosed. More particularly, the present invention relates to a combination of a liquid or solid fabric conditioning composition and a softening booster for treating a textile to impart softness within a single wash and/or rinse cycle. Compositions employed therein are further disclosed.Type: GrantFiled: November 21, 2014Date of Patent: November 29, 2016Assignee: Ecolab USA Inc.Inventors: Amanda Ruth Blattner, Charles Allen Hodge, Claire Lucille Notermann, Julio R. Panama, Shaun Patrick Kennedy
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Patent number: 9506016Abstract: A solid composition for treating cooling or heated water systems to remove scale, microorganisms and biofilm, and corrosion by-products. The composition for cooling towers and chilled water systems comprises chelating agents and an anionic surfactant. The composition for boilers and heated water systems comprises a sulfite, neutralizing amines, sodium phosphate, a polymethacrylate or polyacrylate polymer. A method for using such a treatment composition comprises contacting the treatment composition with substantially all parts of the water system.Type: GrantFiled: November 6, 2013Date of Patent: November 29, 2016Assignee: NCH CorporationInventors: Ecaterina Henderson, Pedro G. Gomez, John T. Buxton, Lyle H. Steimel
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Patent number: 9506017Abstract: Cleaning compositions and methods of making and using the same are provided. The cleaning compositions of the present invention may include at least one alkyl 3-hydroxybutyrate and water, optionally including at least one surfactant and one or more additional additives. The cleaning compositions of the present invention, which are non-toxic and environmentally benign, can be useful to remove many types of soils from a range of different substrates in a variety of domestic, industrial, and/or institutional applications.Type: GrantFiled: April 13, 2015Date of Patent: November 29, 2016Assignee: Eastman Chemical CompanyInventors: Jos Simon De Wit, Mark Stanley Pavlin
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Patent number: 9506018Abstract: An aqueous composition comprising at least one surfactant; a suspending agent comprising micro fibrous cellulose; 10 to 600 ppm of an alkaline earth metal ion, and water. The composition can be used to structure surfactant systems to suspend material in the composition.Type: GrantFiled: November 4, 2010Date of Patent: November 29, 2016Assignee: Colgate-Palmolive CompanyInventors: Robert D'Ambrogio, Joan Ethel Gambogi
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Patent number: 9506019Abstract: Silicone nanoemulsions that include alkylene glycol alkyl ethers. Treatment compositions that include such silicone nanoemulsions. Methods of making such nanoemulsions and treatment compositions.Type: GrantFiled: January 25, 2016Date of Patent: November 29, 2016Assignee: The Procter & Gamble CompanyInventors: Nicholas David Vetter, Patrick Brian Whiting
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Patent number: 9506020Abstract: An automatic dishwashing composition offering good performance especially in the removal of stubborn stains, such as tea stains, comprises a chelating agent selected from hydroxyethyliminodiacetic acid, glucoheptonic acid, hydroxyethylethylenediaminetriacetic acid, poly(acrylic acid-co-hypophosphite), and salts, complexes and mixtures thereof; wherein the composition is substantially free of phosphate containing builders and substantially free of bleaching compounds.Type: GrantFiled: September 22, 2011Date of Patent: November 29, 2016Assignee: Innospec LimitedInventors: Matthew Robert Giles, Nicholas John Dixon
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Patent number: 9506021Abstract: To maintain a uniform etching rate during cleaning of a responsive glass in a glass electrode, a responsive-glass cleaning liquid for a glass electrode 1 serves to clean a responsive glass 2 used in the glass electrode 1, is used with a hydrated-layer forming solution for forming a hydrated layer on the surface of the responsive glass 2, and contains ammonium hydrogen fluoride having a predetermined concentration, or a salt of a strong base containing hydrofluoric acid and a fluoride ion.Type: GrantFiled: September 2, 2014Date of Patent: November 29, 2016Assignee: HORIBA, LTD.Inventors: Manabu Shibata, Nahoko Nishimura, Takeshi Mori, Hisashi Yamanouchi, Katsuaki Ogura
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Patent number: 9506022Abstract: A soaped paper which will disaggregate in aqueous liquids comprising: a. cellulose-based fiber pulp: 50-90% by weight; b. disaggregating agent: 30-3% by weight; c. at least one detergent; is described. The preferred disaggregating agent is the sodium salt of carboxymethylcellulose. This paper can be used to wash parts of the body of people or animals; it is also dry, may be available in the form of rolls, does not leave residues which have to be disposed of and is produced using automatic industrial processes.Type: GrantFiled: February 21, 2013Date of Patent: November 29, 2016Inventor: Danilo Ronco
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Patent number: 9506023Abstract: The invention relates to an alcoholic beverage containing between 15 and 150 g/l of a particulate nut material, wherein the nut material has a particle size, preferably bimodal, between 0.05 and 200 ?m and the beverage contains 5 between 0.2 and 1.0 wt. % of a stabiliser comprising microcrystalline cellulose and optionally a soluble and/or anionic polysaccharide such as CMC.Type: GrantFiled: August 12, 2009Date of Patent: November 29, 2016Assignee: FrieslandCampina Nederland Holding B.V.Inventors: Antonius Johannes Maria Gerrits, Rianne Maria Allegonda Hendrik Van Schaijk
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Patent number: 9506024Abstract: A self-contained circulation system, which supports the formation of capillaries in capillary growth sections and allows the formation of micro organoids and/or micro tissue sections for monitoring the effect of one or more test compounds and determining efficacy, side-effects, biosafety, metabolites, mode of action or organ regeneration as well as methods of establishing such micro organoids and/or micro tissue in the self-contained circulation system.Type: GrantFiled: August 5, 2011Date of Patent: November 29, 2016Assignee: TISSUSE GMBHInventors: Uwe Marx, Gerd Lindner, Reyk Horland, Silke Hoffmann, Roland Lauster
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Patent number: 9506025Abstract: A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically stretching and relaxing the support at least twice along a first axis during a first time period; and then (c) optionally but preferably maintaining the support in a substantially static position during a second time period; and then (d) repeating steps (b) and (c) for a number of times sufficient to enhance the functionality of the tissue formed on the support and/or produce organized skeletal muscle tissue on the solid support from the precursor muscle cells.Type: GrantFiled: April 24, 2009Date of Patent: November 29, 2016Assignee: Wake Forest University Health SciencesInventors: James Yoo, Joel Stitzel, Anthony Atala, George Christ
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Patent number: 9506026Abstract: A culture apparatus includes a heat insulating box main body having an inner box; a culture vessel; a duct and a circulation blower forcing convection of a gas in the culture vessel; a humidifying pan disposed on the bottom of the culture vessel and positioned inside the duct; a heat pipe having a heat insulating section, a heat input section disposed at one end of the heat insulating section and a heat dissipation section disposed at the other end of the heat insulating section. The heat pipe is attached to the culture apparatus with the heat dissipation section being disposed outside the culture apparatus, the heat insulating section passing through the heat insulating box main body and the inner box, and the heat input section being disposed in a gas passage in the duct.Type: GrantFiled: July 21, 2014Date of Patent: November 29, 2016Assignee: PASONIC HEALTHCARE HOLDINGS CO., LTD.Inventors: Naoyuki Yamasaki, Yasuhiro Kikuchi, Hiroki Busujima, Yasutoshi Okamoto
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Patent number: 9506027Abstract: A hydrogel tissue engineering scaffold having microbubbles dispersed therein is disclosed. Also, a system for cell culturing including a controller and actuator to apply dynamic deformational loading to a hydrogel is disclosed. Also disclosed are methods for producing hydrogels with microbubbles and for culturing cells using hydrogels with microbubbles.Type: GrantFiled: November 22, 2013Date of Patent: November 29, 2016Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Mark A. Borden, Eric G. Lima, Clark T. Hung, Shashank Ramesh Sirsi
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Patent number: 9506028Abstract: The present invention relates to a cell lysis apparatus and a manufacturing method thereof, and more particularly, to a cell lysis apparatus, which mechanically performs cell lysis, and a manufacturing method thereof. The cell lysis apparatus includes: an inlet port through which fluid containing cells is supplied; a fluid channel defining a passage through which the cell containing fluid supplied from the inlet port flows; a nano blade array including a plurality of nano blades having pointed leading ends and arranged such that the pointed leading ends of the nano blades are oriented in a direction of the fluid supplied through the inlet port to disrupt the cells passing therethrough; and an outlet port through which the disrupted cells and the fluid are discharged.Type: GrantFiled: August 30, 2010Date of Patent: November 29, 2016Assignee: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Sung Yang, Sung Sik Yun, Sang Youl Yoon
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Patent number: 9506029Abstract: The present invention provides devices, compositions and methods for maintaining conditions in a cell culture and for measurement of conditions in the cell culture. In particular, the invention provides hydrogel materials, apparatus and methods for several non-invasive techniques of maintaining optimal or near-optimal nutrient and pH levels in cell cultures.Type: GrantFiled: December 30, 2011Date of Patent: November 29, 2016Assignee: University of Massachusetts LowellInventors: Daniel Schmidt, Emmanuelle Reynaud, Peter Gaines
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Patent number: 9506030Abstract: Described herein are conjugated modified oligonucleotides that are complementary to a target RNA. The conjugate facilitates cellular uptake of the modified oligonucleotide, resulting improved potency.Type: GrantFiled: April 30, 2014Date of Patent: November 29, 2016Assignee: Regulus Therapeutics Inc.Inventor: Balkrishen Bhat
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Patent number: 9506031Abstract: Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage.Type: GrantFiled: December 8, 2014Date of Patent: November 29, 2016Assignee: University of Central Florida Research Foundation, Inc.Inventors: Kiminobu Sugaya, Angel Alvarez
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Patent number: 9506032Abstract: Biological pacemakers engineered to intrinsically generate rhythmic excitations are disclosed. In addition, methods of producing the biological pacemakers are disclosed. Methods of treating or preventing arrhythmia and heart disease associated with a defective pacemakers are also disclosed.Type: GrantFiled: May 21, 2010Date of Patent: November 29, 2016Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Pittsburgh—of The Commonwealth System of Higher EducationInventors: Victor Maltsev, Edward G. Lakatta, Ihor Zahanich, Syevda Sirenko, Maxim Mikheev, Yoram Vodovotz
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Patent number: 9506033Abstract: Provided herein are methods of inducing differentiation of a mammalian myoblast into a mammalian myocyte that include contacting a mammalian myoblast with an oligonucleotide that decreases Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) mRNA expression in a mammalian myoblast or myocyte. Also provided are methods of inducing mammalian myoblasts or myocytes to form a myotube that include contacting two or more mammalian myoblasts or two or more mammalian myocytes with an oligonucleotide that decreases Map4k4 mRNA expression in a mammalian myoblast or myocyte. Also provided are methods of identifying a candidate agent useful for inducing muscle formation, and compositions containing an oligonucleotide that decreases Map4k4 mRNA expression in mammalian myoblast or myocyte and one or more additional muscle therapeutic agents and/or muscle-building neutraceuticals.Type: GrantFiled: May 21, 2013Date of Patent: November 29, 2016Assignee: University of MassachusettsInventors: Michael P. Czech, Mengxi Wang
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Patent number: 9506034Abstract: The present disclosure relates to compositions and methods comprising cell surface markers for hES-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells, derived from hES cells.Type: GrantFiled: April 30, 2015Date of Patent: November 29, 2016Assignee: ViaCyte, Inc.Inventors: Olivia Kelly, Anne Bang
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Patent number: 9506035Abstract: The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular, one aspect of the present invention provides methods and compositions comprising the use of a population of stromal vascular fraction (SVF) cells to encapsulate or surround a tissue or cell transplant to enhance vascularization of the tissue or cell transplant. Another aspect of the present invention provides methods and compositions for enhancing vascularization of a tissue or cell transplant by combining a population of SVF cells with a tissue or cell transplant to form a transplant mixed with SVF cells. In some embodiments, the SVF cells can be on the surface or embedded within a three-dimensional matrix. In some embodiments, the SVF cells can be generically engineered to secrete therapeutic proteins or pro-angiogenic factors.Type: GrantFiled: October 13, 2010Date of Patent: November 29, 2016Assignee: University of Louisville Research Foundation, IncInventors: Stuart K. Williams, James Beatty Hoying, Laxminarayanan Krishnan
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Patent number: 9506036Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells, wherein greater than 80% of the cells in the population express markers characteristic of the definitive endoderm lineage.Type: GrantFiled: August 17, 2011Date of Patent: November 29, 2016Assignee: Janssen Biotech, Inc.Inventor: Benjamin Fryer
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Patent number: 9506037Abstract: A bicellular vascular population derived from human pluripotent stem cells (hPSCs) undergoes morphogenesis and assembly in a synthetic hydrogel. It is shown that hPSCs can be induced to co-differentiate into early vascular cells (EVCs) in a clinically-relevant strategy dependent upon Notch activation. These EVCs mature into ECs and pericytes, and self-organize to form vascular networks in an engineered matrix. Upon in vivo implantation, multicellular human vascular networks are functionally perfused. Thus, a derived bicellular population is exploited for its intrinsic self-assembly capability to create functional microvasculature in a deliverable matrix.Type: GrantFiled: March 15, 2013Date of Patent: November 29, 2016Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Sharon Gerecht, Sravanti Kusuma
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Patent number: 9506038Abstract: The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are methods of delivering a chemotherapeutic agent to a cancer cell by contacting a cancer cell with an extracellular matrix composition containing a chemotherapeutic agent. Also provided are compositions containing ECM and a chemotherapeutic agent.Type: GrantFiled: May 13, 2015Date of Patent: November 29, 2016Assignee: Histogen, Inc.Inventors: Gail K. Naughton, Emmett Pinney
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Patent number: 9506039Abstract: The invention provides a method of improving the efficiency of establishment of induced pluripotent stem cells by increasing, in a nuclear reprogramming step of somatic cell, the level of activated form of one or more proteins selected from the group consisting of Ras family members, PI3 kinase, RalGEF, Raf, AKT family members, Rheb, TCL1 and S6K. The invention also provides a method of producing induced pluripotent stem cells by contacting a somatic cell with a nuclear reprogramming substance and one or more of such proteins and nucleic acids that encode such proteins. The invention further provides an induced pluripotent stem cell that has an exogenous nucleic acid encoding such a protein, as well as agents for use in the aforesaid methods.Type: GrantFiled: December 2, 2011Date of Patent: November 29, 2016Assignee: Kyoto UniversityInventors: Shinya Yamanaka, Kazutoshi Takahashi, Koji Tanabe
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Patent number: 9506040Abstract: This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue constructs or to revascularize damaged or diseased tissues or organs following implantation. The prevascularized constructs may also deliver genetically engineered gene products to the bloodstream.Type: GrantFiled: May 11, 2009Date of Patent: November 29, 2016Assignee: The Arizona Board of Regents on behalf of the University of ArizonaInventors: Stuart K. Williams, James B. Hoying, Benjamin R. Shepherd
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Patent number: 9506041Abstract: Described herein are compositions relating to alphavirus-based virus-like particles (VLPs) and methods for making and using the described VLPs. The described compositions include VLPs and vectors and cells used to produce the VLPs. Also included are related methods to produce the VLPs, to transduce cells using the VLPs, and to produce a protein or polynucleotide of interest in a target cell using the VLPs. Also described are alphavirus-based replicons that allow for expression of proteins or polynucleotides of interest in a target cell without a cytopathic effect.Type: GrantFiled: March 15, 2013Date of Patent: November 29, 2016Assignee: The United States of America, as represented by the Secretary, Dept. of Health and Human ServicesInventors: Stanislaw J Kaczmarczyk, Deb K. Chatterjee
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Patent number: 9506042Abstract: The present invention provides a novel glucose dehydrogenase that has excellent substrate specificity, specific activity, thermal stability, and the like, and that is suitable for use in SMBG sensors. The present invention provides a purified polypeptide comprising an amino acid sequence having at least 80% identity to the sequence of SEQ ID NO: 1 and having glucose dehydrogenase activity.Type: GrantFiled: December 29, 2014Date of Patent: November 29, 2016Assignee: Toyobo Co., Ltd.Inventors: Yosuke Sumida, Rie Hirao, Yuu Utashima, Hiroaki Kitazawa, Hiroshi Aiba, Takahide Kishimoto, Shusaku Yanagidani
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Patent number: 9506043Abstract: A novel diaphorase; a method for producing the diaphorase; and use of the diaphorase are provided. The diaphorase comprises any one of the following polypeptides (a) to (c): (a) a polypeptide having the amino acid sequence of SEQ ID NO: 1, (b) a polypeptide having the amino acid sequence of SEQ ID NO: 1 in which one or several amino acid residues are substituted, deleted, inserted, added, and/or inverted, and having diaphorase activity, and (c) a polypeptide having an amino acid sequence with 80% or more identity to the amino acid sequence of SEQ ID NO: 1, and having diaphorase activity.Type: GrantFiled: December 19, 2012Date of Patent: November 29, 2016Assignee: TOYOBO CO., LTD.Inventors: Sachio Iwai, Takahide Kishimoto, Seiji Takeshima, Shusaku Yanagidani
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Patent number: 9506044Abstract: The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: GrantFiled: August 10, 2012Date of Patent: November 29, 2016Assignee: Novozymes A/SInventors: Sara Landvik, Lars H. Oestergaard, Lisbeth Kalum
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Patent number: 9506045Abstract: Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.Type: GrantFiled: December 11, 2013Date of Patent: November 29, 2016Assignee: Roche Molecular Systems, Inc.Inventor: Shawn Suko
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Patent number: 9506046Abstract: The present invention relates to isolated polypeptides having amylolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: GrantFiled: November 2, 2009Date of Patent: November 29, 2016Assignee: Novozymes, Inc.Inventors: Paul Harris, Mark Wogulis
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Patent number: 9506047Abstract: The present invention relates to alpha-amylases, nucleic acids encoding the alpha-amylases, methods of producing the alpha-amylases, and methods of using the alpha-amylases.Type: GrantFiled: April 27, 2015Date of Patent: November 29, 2016Assignee: NOVOZYMES A/SInventors: Carsten Andersen, Thomas Agersten Poulsen